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Alejandro Samhan Arias. Concluiu o(a) Doctor em Señalización Celular y Patologías Asociadas em 2008 pelo(a) Universidad de Extremadura, DEA em Avances en Estudio del Comportamiento de Organismos Uni y Pluricelulares em 2005 pelo(a) Universidad de Extremadura, DEA em Señalización Celular y Patologías Asociadas em 2007 pelo(a) Universidad de Extremadura e Licence em Biology em 2002/07/31 pelo(a) Universidad de Extremadura. É Professor Auxiliar no(a) Universidad Autónoma de Madrid. Publicou 56 artigos em revistas especializadas. Possui 3 capítulo(s) de livros e 8 livro(s). Recebeu 2 prémio(s) e/ou homenagens. Atua na(s) área(s) de Ciências Naturais com ênfase em Ciências Biológicas com ênfase em Bioquímica e Ciências Médicas e da Saúde com ênfase em Medicina Básica com ênfase em Química Médica. Nas suas atividades profissionais interagiu com 196 colaborador(es) em coautorias de trabalhos científicos. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: b-Type hemoproteins; Cytochrome b; Hydrogen peroxide; Oxygenase; Peroxidase; Tyrosine ionization; Biomarcadores; Saúde; Sensores; Stress e Emoções; Big data; Blood; Electroanalysis; Emotions; Stress; Sweat; Crohn; Ulcerative colitis; doença; Ulcerative Colitis;.
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Identification

Personal identification

Full name
Alejandro Samhan Arias

Citation names

  • Samhan-Arias, Alejandro
  • Samhan-Arias AK

Author identifiers

Ciência ID
FA18-48B6-B02A
ORCID iD
0000-0001-9602-4848

Email addresses

  • alejandro.samhan@uam.es (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Spanish; Castilian Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2)
Education
Degree Classification
2008
Concluded
 Señalización Celular y Patologías Asociadas (Doctor)
Universidad de Extremadura, Spain
"Characterization and location of the NADH dependent redox centers associated to the plasma membrane of neurons." (THESIS/DISSERTATION)
 Sobresaliente Cum Laude (Por Unanimidad). Highest
2007
Concluded
 Señalización Celular y Patologías Asociadas (DEA)
Universidad de Extremadura, Spain
"MESTRADO 2 (from 2) “Señalización Celular y Patologias Asociadas” " (THESIS/DISSERTATION)
 9/10
2005
Concluded
 Avances en Estudio del Comportamiento de Organismos Uni y Pluricelulares (DEA)
Universidad de Extremadura, Spain
"MESTRADO 1 (from 2): "AVANCES EN ESTUDIO DEL COMPORTAMIENTO DE ORGANISMOS UNI Y PLURICELULARES"" (THESIS/DISSERTATION)
 9.45/10
2002/07/31
Concluded
 Biology (Licence)
Universidad de Extremadura, Spain
"Overexpression and characterization of selenium containing enzymes (Project)" (THESIS/DISSERTATION)
 7.129/10
Affiliation

Science

Category
Host institution 		Employer
2018/12/19 - 2019/11/30 Researcher (Research) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/03/01 - 2018/02/28 Postdoc (Research) Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2011/01/01 - 2014/12/31 Researcher (Research) Universidad de Extremadura - Campus Badajoz, Spain
2009/01/01 - 2011/01/01 Postdoc (Research) University of Pittsburgh Department of Environmental and Occupational Health, United States

Teaching in Higher Education

Category
Host institution 		Employer
2019/12/01 - Current Assistant Professor (University Teacher) Universidad Autónoma de Madrid, Spain
Universidad Autónoma de Madrid Facultad de Medicina, Spain

Others

Category
Host institution 		Employer
2015/01/01 - 2015/01/31 CEO of the Crohn's disease and Ulcerative Colitis Spanish Patient's Association (ACCU ESPAÑA). Main part of the work dedicated to project management and coordinator of the Research Area. Grupo Español de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa, Spain
2004/12/01 - 2008/11/01 Bolseiro/Contratado predoctoral Universidad de Extremadura - Campus Badajoz, Spain
2004/04/01 - 2004/11/01 Research project technician SAF2003-08275 (Spanish MEC) Universidad de Extremadura - Campus Badajoz, Spain
2002/11/01 - 2003/08/01 Research project technician BMC200-0547 (Spanish MEC) Universidad de Extremadura - Campus Badajoz, Spain
2001/01/01 - 2001/06/30 Research scholarship of the Programa Propio (University of Extremadura-2001) . Universidad de Extremadura - Campus Badajoz, Spain
Projects

Contract

Designation Funders
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
UIDB/04378/2020
10.54499/UIDB/04378/2020
Universidade do Porto, Portugal

Universidade Nova de Lisboa, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/10/01 - 2022/06/30 Detecção de biomarcadores de stress físico e emocional através de técnicas não invasivas
PTDC/SAU-SOC/28390/2017
Associação para a Inovação e Desenvolvimento da FCT, Portugal

Centro Tecnológico das Indústrias Têxtil e do Vestuário de Portugal, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Unidade de Ciências Biomoleculares Aplicadas
UID/Multi/04378/2019
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Universidade Nova de Lisboa Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018/12/19 - 2019/12/01 Não disponível
DL 57/2016/CP1379/CT0042
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2015/03/01 - 2018/12/18 Functional and structural modulation of cytochrome b5 reductase and cytochrome b5 by nitric oxide and peroxynitrite
SFRH/BPD/100069/2014
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Samhan-Arias, A.K.; Gutierrez-Merino, C.; Alejandro K. Samhan Arias; Carlos Gutierrez-Merino. Cytochrome b5 as a pleiotropic metabolic modulator in mammalian cells. United Kingdom: Nova Science Publishers, Inc.. 2014.
  2. Lagoa, R.; Lopez-Sanchez, C.; Samhan-Arias, A. K.; Ganan, C. M.; Garcia-Martinez, V.; Gutierrez-Merino, C.. Neuroprotective effect of kaempferol in the 3-nitropropionic acid model of Huntington's disease. 2009.
  3. Silva, D. M.; Samhan-Arias, A. K.; Garcia-Bereguiain, M. A.; Tiago, T.; Gutierrez-Merino, C.. Major plasma membrane-associated redox centres co-localize with L-type calcium channels in neuronal lipid rafts microdomains. 2009.
  4. Tiago, T.; Silva, D.; Samhan-Arias, A. K.; Aureliano, M.; Gutierrez-Merino, C.. Actin cytoskeleton disruption is an early event upon exposure of cerebellar granule neurons to SIN-1-induced oxidative stress. 2009.
  5. Samhan-Arias, A. K.; Gutierrez-Merino, C.. Plasma Membrane-bound Cytochrome b(5) Reductase Is Associated with Lipid Rafts in Cerebellar Granule Neurons in Culture. 2008.
  6. Lopez-Sanchez, C.; Martin-Romero, F. J.; Sun, F.; Luis, L.; Samhan-Arias, A. K.; Garcia-Martinez, V.; Gutierrez-Merino, C.. Intravenous Injections of Kaempferol Afford Protection Against Rat Brain Damage Induced by Transient Focal Ischemia. 2008.
  7. Tiago, T.; Samhan-Arias, A. K.; Gutierrez-Merino, C.. Cytoskeleton Dynamics Modulates the Regionalization of Plasma Membrane-bound Cytochrome B(5) Reductase in Cerebellar Granule Neurons In Culture. 2008.
  8. Samhan-Arias, A. K.; Garcia-Bereguiain, M. A.; Gutierrez-Merino, C.; Medimond,. Plasma membrane-bound cytochrome B(5) reductase forms a large network of redox centres that co-localise with cholera toxin B binding sites in cerebellar granule neurones in culture. 2007.
Book chapter
  1. Cordas, Cristina M.; Nunes, M. João; Valério, Gabriel N.; Samhan-Arias, Alejandro; Krippahl, Ludwig; Moura, José J. G.; Santos, Gilda; Sousa, João P.; Rouco, Carlos. "Sweat as a Testing Analytical Fluid for Emotions and Stress Biomarkers Detection". In Developments and Advances in Defense and Security, 77-85. Singapore: Springer Nature Singapore, 2023.
    Published • 10.1007/978-981-19-7689-6_7
  2. Arias, Alejandro. "Neurochemistry". 2014.
  3. Carlos Gutierrez-Merino; Dorinda Marques-da-Silva; Sofia Fortalezas; Alejandro K. Samhan Arias. "Cytosolic Calcium Homeostasis in Neurons — Control Systems, Modulation by Reactive Oxygen and Nitrogen Species, and Space and Time Fluctuations". edited by T Heinbockel, 59-59. United Kingdom: InTech, 2014.
Conference abstract
  1. Cordas, Cristina M.; Nunes, M. João; Moura, José J. G. ; Krippahl, Ludwig; Samhan-Arias, Alejandro; Rouco, Carlos; Sousa, João Paulo. "Non-invasive human stress biomarkers detection-Project Stressense". Paper presented in 3rd HBM-PT - Workshop on Human BioMonitoring in Portugal, Virtual, Workshop on Human BioMonitoring in Portugal, 2020.
    Published
  2. Cordas, Cristina; Nunes, M. João; Valério, Gabriel; Samhan-Arias, Alejandro; Moura, José J. G. ; Sousa, João P.; Rouco, Carlos. "Electrochemical qualitative detection of stress biomarkers in simulated and real sweat samples". Paper presented in Analítica 2020 - 10º Encontro da Divisão de Química Analítica da SPQ, Lisbon, 2020.
    Published
  3. Samhan-Arias, Alejandro; Cordas, Cristina; Carepo, Marta; Maia, Luisa; Moura, José. Corresponding author: Samhan-Arias, Alejandro. "Structural and functional characterization of the acid and alkaline transition of cytochrome b5 (conference abstract)". Paper presented in 19th biennial meeting for the Society for Free Radical Research International (SFRRI), Lisbon, 2018.
    Published
Conference paper
  1. Cristina M. Cordas; Maria João Nunes; Gabriel N. Valério; Alejandro K. Samhan Arias; Ludwig Krippahl; José J. G. Moura; Gilda Santos; João P. Sousa; Carlos Rouco. "Stress Biomarkers Detection Using Non-invasive Methods for Textiles Integrated Sensors Development". 2022.
    10.1007/978-981-16-4884-7_21
Conference poster
  1. João Paulo Sousa; Nunes, M. João; Valério, Gabriel Nóbrega; Moura, José J. G.; Krippahl, Ludwig; Samhan-Arias, Alejandro; Rouco, Carlos; Cordas, Cristina M.. "Military Healthcare During Physical Exercises ¿ Monitoring human stress biomarkers in sweat". Paper presented in 8thEuChemS Chemistry Congress (ECC8), 2022.
Journal article
  1. João Lopes; Dorinda Marques-da-Silva; Paula A. Videira; Alejandro K. Samhan-Arias; Ricardo Lagoa. "Cardiolipin Membranes Promote Cytochrome c Transformation of Polycyclic Aromatic Hydrocarbons and Their In Vivo Metabolites". Molecules (2024): https://doi.org/10.3390/molecules29051129.
    10.3390/molecules29051129
  2. Alejandro Samhan-Arias; Joana Poejo; Dorinda Marques-da-Silva; Oscar Martínez-Costa; Carlos Gutierrez-Merino. "Are There Lipid Membrane-Domain Subtypes in Neurons with Different Roles in Calcium Signaling?". Molecules (2023): https://doi.org/10.3390/molecules28237909.
    10.3390/molecules28237909
  3. Jairo Salazar; Alejandro K. Samhan-Arias; Carlos Gutierrez-Merino. "Hexa-Histidine, a Peptide with Versatile Applications in the Study of Amyloid-ß(1–42) Molecular Mechanisms of Action". Molecules (2023): https://doi.org/10.3390/molecules28207138.
    10.3390/molecules28207138
  4. Oscar H. Martínez-Costa; Laura Rodrigues-Miranda; Sofia M. Clemente; António Jorge Parola; Nuno Basilio; Alejandro K. Samhan-Arias. "The Use of Flavylium Salts as Dynamic Inhibitor Moieties for Human Cb5R". Molecules (2022): https://doi.org/10.3390/molecules28010123.
    10.3390/molecules28010123
  5. Berta Gorospe; José J. G. Moura; Carlos Gutierrez-Merino; Alejandro K. Samhan-Arias. "Biochemical and Biophysical Characterization of the Caveolin-2 Interaction with Membranes and Analysis of the Protein Structural Alteration by the Presence of Cholesterol". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232315203.
    10.3390/ijms232315203
  6. Maria João Nunes; José J. G. Moura; João Paulo Noronha; Luís Cobra Branco; Alejandro Samhan-Arias; João P. Sousa; Carlos Rouco; Cristina M. Cordas. "Evaluation of Sweat-Sampling Procedures for Human Stress-Biomarker Detection". Analytica 3 2 (2022): 178-194. https://doi.org/10.3390/analytica3020013.
    10.3390/analytica3020013
  7. Jairo Salazar; Joana Poejo; Ana M. Mata; Alejandro K. Samhan-Arias; Carlos Gutierrez-Merino. "Design and Experimental Evaluation of a Peptide Antagonist against Amyloid ß(1–42) Interactions with Calmodulin and Calbindin-D28k". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23042289.
    10.3390/ijms23042289
  8. Nunes, M.J.; Valério, G.N.; Samhan-Arias, A.; Moura, J.J.G.; Rouco, C.; Sousa, J.P.; Cordas, C.M.. "Screen-Printed Electrodes Testing for Detection of Potential Stress Biomarkers in Sweat". Electrocatalysis 13 3 (2022): 299-305. http://www.scopus.com/inward/record.url?eid=2-s2.0-85124728032&partnerID=MN8TOARS.
    10.1007/s12678-022-00709-7
  9. Carlos Gutiérrez-Merino; Oscar H. Martínez-Costa; Maria Monsalve; Alejandro K. Samhan-Arias. "Structural Features of Cytochrome b5–Cytochrome b5 Reductase Complex Formation and Implications for the Intramolecular Dynamics of Cytochrome b5 Reductase". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms23010118.
    10.3390/ijms23010118
  10. Laura Doblado; Claudia Lueck; Claudia Rey; Alejandro K. Samhan-Arias; Ignacio Prieto; Alessandra Stacchiotti; Maria Monsalve. "Mitophagy in Human Diseases". International Journal of Molecular Sciences 22 8 (2021): 3903-3903. https://doi.org/10.3390/ijms22083903.
    10.3390/ijms22083903
  11. Sofia M. Clemente; Oscar H. Martinez-Costa; Maria Monsalve; Alejandro K. Samhan Arias. "Targeting Lipid Peroxidation for Cancer Treatment". Molecules (2020): https://www.mdpi.com/1420-3049/25/21/5144.
    10.3390/molecules25215144
  12. Arias, Alejandro. "Cholesterol-Rich Plasma Membrane Submicrodomains Can Be a Major Extram- itochondrial Source of Reactive Oxygen Species in Partially Depolarized Mature Cerebellar Granule Neurons in Culture". jnnd (2019): http://dx.doi.org/10.17303/jnnd.2019.5.204.
    10.17303/jnnd.2019.5.204
  13. Arias, Alejandro. "Human erythrocytes exposure to juglone leads to an increase of superoxide anion production associated with cytochrome b5 reductase uncoupling". Biochimica et Biophysica Acta (BBA) - Bioenergetics (2019): http://dx.doi.org/10.1016/j.bbabio.2019.148134.
    10.1016/j.bbabio.2019.148134
  14. Alejandro K. Samhan Arias; Cristina M. Cordas; Marta Carepo; Luisa Maia; Carlos Gutierrez-Merino; Isabel Moura; José J. G. Moura. "Ligand accessibility to heme cytochrome b 5 coordinating sphere and enzymatic activity enhancement upon tyrosine ionization". Journal of Biological Inorganic Chemistry 24 3 (2019): 317-330. https://unl.elsevierpure.com/en/publications/8dcd3e7b-e024-4451-acf3-a04b8895a928.
    10.1007/s00775-019-01649-2
  15. Mohammadyani D; Yanamala N; Samhan Arias AK; Kapralov AA; Stepanov G; Nuar N; Planas-Iglesias J; et al. "Structural characterization of cardiolipin-driven activation of cytochrome C into a peroxidase and membrane perturbation.". Biochimica et biophysica acta (2018): http://europepmc.org/abstract/med/29317202.
    10.1016/j.bbamem.2018.01.009
  16. Arias, Alejandro. "P-213 - Structural and functional characterization of the acid and alkaline transition of cytochrome b5". Free Radical Biology and Medicine 120 (2018): S109-S109. http://www.sciencedirect.com/science/article/pii/S0891584918305252.
    https://doi.org/10.1016/j.freeradbiomed.2018.04.360
  17. Samhan-Arias, Alejandro K.; Fortalezas, Sofia; Cordas, Cristina M.; Moura, Isabel; Moura, José J. G.; Gutierrez-Merino, Carlos; Arias, Alejandro. "P-363 - Cytochrome c stimulates the superoxide anion production by cytochrome b5 reductase in neuronal synaptic plasma membrane vesicles". Free Radical Biology and Medicine 120 (2018): S155-S155. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000432836500495&KeyUID=WOS:000432836500495.
    10.1016/j.freeradbiomed.2018.04.510
  18. Samhan-Arias, Alejandro; Cordas, Cristina; Carepo, Marta; Maia, Luisa; Moura, Jose. "Structural and functional characterization of the acid and alkaline transition of cytochrome b5". Free Radical Biology and Medicine 120 (2018): S109-S109. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000432836500345&KeyUID=WOS:000432836500345.
    10.1016/j.freeradbiomed.2018.04.360
  19. Samhan-Arias, Alejandro K; Almeida, Rui M; Ramos, Susana; Cordas, Cristina M; Moura, Isabel; Gutierrez-Merino, Carlos; Moura, Jose J G. "Topography of human cytochrome b/cytochrome b reductase interacting domain and redox alterations upon complex formation.". Biochimica et biophysica acta 1859 2 (2017): 78-87. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:29111436&KeyUID=MEDLINE:29111436.
    10.1016/j.bbabio.2017.10.005
  20. Samhan-Arias, Alejandro K; Maia, Luisa B; Cordas, Cristina M; Moura, Isabel; Gutierrez-Merino, Carlos; Moura, Jose J G. "Peroxidase-like activity of cytochrome b is triggered upon hemichrome formation in alkaline pH.". Biochimica et biophysica acta (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:28958890&KeyUID=MEDLINE:28958890.
    10.1016/j.bbapap.2017.09.010
  21. Samhan-Arias, A. K.; Fortalezas, S.; Cordas, C. M.; Moura, I.; Moura, J. J. G.; Gutierrez-Merino, C.. "Cytochrome b5 reductase is the component from neuronal synaptic plasma membrane vesicles that generates superoxide anion upon stimulation by cytochrome c". Redox Biol 15 (2017): 109-114. https://www.ncbi.nlm.nih.gov/pubmed/29227865.
    10.1016/j.redox.2017.11.021
  22. Lagoa, R.; Samhan-Arias, A.K.; Gutierrez-Merino, C.. "Correlation between the potency of flavonoids for cytochrome c reduction and inhibition of cardiolipin-induced peroxidase activity". BioFactors (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000403362800011&KeyUID=WOS:000403362800011.
    10.1002/biof.1357
  23. Arias, Alejandro. "Biochemical and anatomical basis of brain dysfunctions caused by cytochrome b5 reductase deficiency or dysregulation". Journal of Neurology & Neuromedicine (2016): http://www.jneurology.com/articles/biochemical-and-anatomical-basis-of-brain-dysfunctions-caused-by-cytochrome-b-reductase-deficiency-or-dysregulation-neuromed-1-1066.php.
  24. Arias, Alejandro. "The critical role of lipid rafts nanodomains in the cross-talk between calcium and reactive oxygen and nitrogen species in cerebellar granule neurons apoptosis by extracellular potassium deprivation,". AIMS Molecular Science (2016): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000372799600002&KeyUID=WOS:000372799600002.
    10.3934/molsci.2016.1.12
  25. Samhan-Arias, A. K.; Lopez-Sanchez, C.; Marques-da-Silva, D.; Lagoa, R.; Garcia-Lopez, V.; Garcia-Martinez, V.; Gutierrez-Merino, C.. "High expression of cytochrome b (5) reductase isoform 3/cytochrome b (5) system in the cerebellum and pyramidal neurons of adult rat brain". Brain Structure & Function 221 4 (2016): 2147-2162. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000375558600024&KeyUID=WOS:000375558600024.
    10.1007/s00429-015-1036-5
  26. Samhan-Arias, Alejandro K.; Gutierrez-Merino, Carlos. "Purified NADH-cytochrome b(5) reductase is a novel superoxide anion source inhibited by apocynin: sensitivity to nitric oxide and peroxynitrite". Free Radical Biology and Medicine 73 (2014): 174-189. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000339695600019&KeyUID=WOS:000339695600019.
    10.1016/j.freeradbiomed.2014.04.033
  27. Samhan-Arias, Alejandro K.; Marques-da-Silva, Dorinda; Yanamala, Naveena; Gutierrez-Merino, Carlos. "Stimulation and clustering of cytochrome b(5) reductase in caveolin-rich lipid microdomains is an early event in oxidative stress-mediated apoptosis of cerebellar granule neurons". Journal of Proteomics 75 10 (2012): 2934-2949. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000305266000016&KeyUID=WOS:000305266000016.
    10.1016/j.jprot.2011.12.007
  28. Samhan-Arias, A. K.; Lagoa, R.; Gutierrez-Merino, C.. "Reduction of cytochrome c by flavonoids". Free Radical Biology and Medicine 53 (2012): S104-S104. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000209480800214&KeyUID=WOS:000209480800214.
    10.1016/j.freeradbiomed.2012.08.217
  29. Samhan-Arias, Alejandro K.; Ji, Jing; Demidova, Olga M.; Sparvero, Louis J.; Feng, Weihong; Tyurin, Vladimir; Tyurina, Yulia Y.; et al. "Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin". Biochimica Et Biophysica Acta-Biomembranes 1818 10 (2012): 2413-2423. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000307135500005&KeyUID=WOS:000307135500005.
    10.1016/j.bbamem.2012.03.014
  30. Ji, Jing; Kline, Anthony E.; Amoscato, Andrew; Samhan-Arias, Alejandro K.; Sparvero, Louis J.; Tyurin, Vladimir A.; Tyurina, Yulia Y.; et al. "Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury". Nature Neuroscience 15 10 (2012): 1407-1413. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000309335300021&KeyUID=WOS:000309335300021.
    10.1038/nn.3195
  31. Kapralov, Alexandr A.; Yanamala, Naveena; Tyurina, Yulia Y.; Castro, Laura; Samhan-Arias, Alejandro; Vladimirov, Yuri A.; Maeda, Akihiro; et al. "Topography of tyrosine residues and their involvement in peroxidation of polyunsaturated cardiolipin in cytochrome c/cardiolipin peroxidase complexes". Biochimica Et Biophysica Acta-Biomembranes 1808 9 (2011): 2147-2155. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000293156400007&KeyUID=WOS:000293156400007.
    10.1016/j.bbamem.2011.04.009
  32. Gutierrez-Merino, C.; Lopez-Sanchez, C.; Lagoa, R.; Samhan-Arias, A. K.; Bueno, C.; Garcia-Martinez, V.. "Neuroprotective Actions of Flavonoids". Current Medicinal Chemistry 18 8 (2011): 1195-1212. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000288988100007&KeyUID=WOS:000288988100007.
  33. Samhan-Arias, Alejandro K.; Tyurina, Yulia Y.; Kagan, Valerian E.. "Lipid antioxidants: free radical scavenging versus regulation of enzymatic lipid peroxidation". Journal of Clinical Biochemistry and Nutrition 48 1 (2011): 91-95. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000288981400016&KeyUID=WOS:000288981400016.
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    10.1021/nn202201j
  35. Tiago, Teresa; Marques-da-Silva, Dorinda; Samhan-Arias, Alejandro K.; Aureliano, Manuel; Gutierrez-Merino, Carlos. "Early disruption of the actin cytoskeleton in cultured cerebellar granule neurons exposed to 3-morpholinosydnonimine-oxidative stress is linked to alterations of the cytosolic calcium concentration". Cell Calcium 49 3 (2011): 174-183. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000289384300004&KeyUID=WOS:000289384300004.
    10.1016/j.ceca.2011.01.009
  36. Atkinson, Jeffrey; Kapralov, Alexandr A.; Yanamala, Naveena; Tyurina, Yulia Y.; Amoscato, Andrew A.; Pearce, Linda; Peterson, Jim; et al. "A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death". Nature Communications 2 (2011): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000296787300010&KeyUID=WOS:000296787300010.
    10.1038/ncomms1499
  37. Pecina, Petr; Borisenko, Grigory G.; Belikova, Natalia A.; Tyurina, Yulia Y.; Pecinova, Alena; Lee, Icksoo; Samhan-Arias, Alejandro K.; Kagan, Valerian E.; Huttemann, Maik. "Regulation of mitochondrial respiration and apoptosis through phosphorylation of cytochrome c". Biochimica Et Biophysica Acta-Bioenergetics 1797 (2010): 125-125. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000279662500349&KeyUID=WOS:000279662500349.
    10.1016/j.bbabio.2010.04.374
  38. Pecina, Petr; Borisenko, Grigory G.; Belikova, Natalia A.; Tyurina, Yulia Y.; Pecinova, Alena; Lee, Icksoo; Samhan-Arias, Alejandro K.; et al. "Phosphomimetic Substitution of Cytochrome c Tyrosine 48 Decreases Respiration and Binding to Cardiolipin and Abolishes Ability to Trigger Downstream Caspase Activation". Biochemistry 49 31 (2010): 6705-6714. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000280743200021&KeyUID=WOS:000280743200021.
    10.1021/bi100486s
  39. Hiona, Asimina; Sanz, Alberto; Kujoth, Gregory C.; Pamplona, Reinald; Seo, Arnold Y.; Hofer, Tim; Someya, Shinichi; et al. "Mitochondrial DNA Mutations Induce Mitochondrial Dysfunction, Apoptosis and Sarcopenia in Skeletal Muscle of Mitochondrial DNA Mutator Mice". Plos One 5 7 (2010): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000279589300013&KeyUID=WOS:000279589300013.
    10.1371/journal.pone.0011468
  40. Marques-da-Silva, Dorinda; Samhan-Arias, Alejandro K.; Tiago, Teresa; Gutierrez-Merino, Carlos. "L-type calcium channels and cytochrome b(5) reductase are components of protein complexes tightly associated with lipid rafts microdomains of the neuronal plasma membrane". Journal of Proteomics 73 8 (2010): 1502-1510. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000279970800010&KeyUID=WOS:000279970800010.
    10.1016/j.jprot.2010.02.014
  41. Lagoa, R.; Lopez-Sanchez, C.; Samhan-Arias, A. K.; Ganan, C. M.; Garcia-Martinez, V.; Gutierrez-Merino, C.. "Neuroprotective effect of kaempferol in the 3-nitropropionic acid model of Huntington's disease". Free Radical Research 43 (2009): 71-71. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000267973800172&KeyUID=WOS:000267973800172.
  42. Kagan, Valerian E.; Wipf, Peter; Stoyanovsky, Detcho; Greenberger, Joel S.; Borisenko, Grigory; Belikova, Natalia A.; Yanamala, Naveena; et al. "Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions". Advanced Drug Delivery Reviews 61 14 (2009): 1375-1385. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000272600300014&KeyUID=WOS:000272600300014.
    10.1016/j.addr.2009.06.008
  43. Silva, D. M.; Samhan-Arias, A. K.; Garcia-Bereguiain, M. A.; Tiago, T.; Gutierrez-Merino, C.. "Major plasma membrane-associated redox centres co-localize with L-type calcium channels in neuronal lipid rafts microdomains". Free Radical Research 43 (2009): 69-69. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000267973800164&KeyUID=WOS:000267973800164.
  44. Lagoa, Ricardo; Lopez-Sanchez, Carmen; Samhan-Arias, Alejandro K.; Ganan, Carlos M.; Garcia-Martinez, Virginio; Gutierrez-Merino, Carlos. "Kaempferol protects against rat striatal degeneration induced by 3-nitropropionic acid". Journal of Neurochemistry 111 2 (2009): 473-487. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000270152600017&KeyUID=WOS:000270152600017.
    10.1111/j.1471-4159.2009.06331.x
  45. Gutierrez-Merino, C.; Samhan-Arias, A. K.; Garcia-Bereguiain, M. A.; Samhan-Arias, Alejandro K.; Garcia-Bereguiain, Miguel A.; Gutierrez-Merino, Carlos. "Hydrogen sulfide is a reversible inhibitor of the NADH oxidase activity of the synaptic plasma membrane from rat brain". Free Radical Research 43 4 (2009): 48-48. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000267973800076&KeyUID=WOS:000267973800076.
    10.1016/j.bbrc.2009.08.076
  46. Belikova, Natalia A.; Tyurina, Yulia Y.; Borisenko, Grigory; Tyurin, Vladimir; Arias, Alejandro K. Samhan; Yanamala, Naveena; Furtmueller, Paul Georg; et al. "Heterolytic Reduction of Fatty Acid Hydroperoxides by Cytochrome c/Cardiolipin Complexes: Antioxidant Function in Mitochondria". Journal of the American Chemical Society 131 32 (2009): 11288-+. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000269379200009&KeyUID=WOS:000269379200009.
    10.1021/ja904343c
  47. Samhan-Arias, Alejandro K.; Angel Garcia-Bereguiain, Miguel; Martin-Romero, Francisco J.; Gutierrez-Merino, Carlos. "Clustering of plasma membrane-bound cytochrome b(5) reductase within 'lipid raft' microdomains of the neuronal plasma membrane". Molecular and Cellular Neuroscience 40 1 (2009): 14-26. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000262422700002&KeyUID=WOS:000262422700002.
    10.1016/j.mcn.2008.08.013
  48. Tiago, T.; Marques da Silva, D.; Samhan-Arias, A. K.; Aureliano, M.; Gutierrez-Merino, C.. "Actin cytoskeleton disruption is an early event upon exposure of cerebellar granule neurons to SIN-1-induced oxidative stress". Free Radical Research 43 (2009): 70-70. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000267973800167&KeyUID=WOS:000267973800167.
  49. Samhan-Arias, Alejandro K.; Duarte, Rui O.; Javier Martin-Romero, Francisco; Moura, Jose J. G.; Gutierrez-Merino, Carlos. "Reduction of ascorbate free radical by the plasma membrane of synaptic terminals from rat brain". Archives of Biochemistry and Biophysics 469 2 (2008): 243-254. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252383700011&KeyUID=WOS:000252383700011.
    10.1016/j.abb.2007.10.004
  50. Samhan-Arias, A. K.; Gutierrez-Merino, C.. "Plasma membrane-bound cytochrome b5 reductase is associated with lipid rafts in cerebellar granule neurons in culture". Free Radical Research 42 (2008): S51-S51. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000258622100057&KeyUID=WOS:000258622100057.
  51. Angel Garcia-Bereguiain, Miguel; Khalil Samhan-Arias, Alejandro; Javier Martin-Romero, Francisco; Gutierrez-Merino, Carlos. "Hydrogen sulfide raises cytosolic calcium in neurons through activation of L-type Ca2+ channels". Antioxidants & Redox Signaling 10 1 (2008): 31-41. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000251165100002&KeyUID=WOS:000251165100002.
    10.1089/ars.2007.1656
  52. Tiago, T.; Samhan-Arias, K.; Gutierrez-Merino, C.. "Cytoskeleton dynamics modulates the regionalization of plasma membrane-bound cytochrome b5 reductase in cerebellar granule neurons in culture". Free Radical Research 42 (2008): S120-S120. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000258622100192&KeyUID=WOS:000258622100192.
  53. Lopez-Sanchez, C.; Martin-Romero, F. J.; Sun, F.; Luis, L.; Samhan-Arias, A. K.; Garcia-Martinez, V.; Gutierrez-Merino, C.. "Blood micromolar concentrations of kaempferol afford protection against ischemia/reperfusion-induced damage in rat brain". Free Radical Research 42 (2008): S77-S77. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000258622100110&KeyUID=WOS:000258622100110.
    10.1016/j.brainres.2007.08.087
  54. Samhan-Arias, Alejandro K.; Garcia-Bereguiain, Miguel Angel; Gutierrez-Merino, Carlos. "Plasma membrane-bound cytochrome b(5) reductase forms a large network of redox centres that co-localizes with cholera toxin B binding sites in cerebellar granule neurons in culture". Free Radical Research 41 (2007): S52-S52. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000252296300195&KeyUID=WOS:000252296300195.
  55. Lopez-Sanchez, Carmen; Martin-Romero, Francisco Javier; Sun, Fei; Luis, Laura; Samhan-Arias, Alejandro K.; Garcia-Martinez, Virginio; Gutierrez-Merino, Carlos. "Blood micromolar concentrations of kaempferol afford protection against ischemia/reperfusion-induced damage in rat brain". Brain Research 1182 (2007): 123-137. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000251702700013&KeyUID=WOS:000251702700013.
    10.1016/j.brainres.2007.08.087
  56. Samhan-Arias, A. K.; Garcia-Bereguiain, M. A.; Martin-Romero, F. J.; Gutierrez-Merino, C.. "Regionalization of plasma membrane-bound flavoproteins of cerebellar granule neurons in culture by fluorescence energy transfer imaging". Journal of Fluorescence 16 3 (2006): 393-401. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000238500600016&KeyUID=WOS:000238500600016.
    10.1007/s10895-005-0065-5
  57. Samhan-Arias, A. K.; Martin-Romero, F. J.; Gutierrez-Merino, C.. "Compartmentation of the plasma membrane redox chain in cerebellar granule neurons in culture". Journal of Neurochemistry 94 (2005): 239-239. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000231673401263&KeyUID=WOS:000231673401263.
  58. Samhan-Arias, A. K.; Martin-Romero, F. J.; Gutierrez-Merino, C.. "Kaempferol blocks oxidative stress in cerebellar granule cells and reveals a key role for reactive oxygen species production at the plasma membrane in the commitment to apoptosis". Free Radical Biology and Medicine 37 1 (2004): 48-61. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000222163800005&KeyUID=WOS:000222163800005.
    10.1016/j.freeradbiomed.2004.04.002
  59. Samhan-Arias, A. K.; Martin-Romero, F. J.; Gutierrez-Merino, C.. "Reactive oxygen species production by cerebellar granule cells during the early stage of low potassium-induced apoptosis is mostly oriented towards the extracellular medium and is inhibited by kaempferol". Free Radical Biology and Medicine 35 (2003): S161-S162. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000186658900528&KeyUID=WOS:000186658900528.

Other

Other output
  1. Modulation of cytochrome b5 reductase activity by 5-hydroxy-1,4-naphthoquinone. 2019. Gabriel N. Valério; Carlos Gutierrez-Merino; Isabel Moura; José J. G. Moura; Alejandro K. Samhan Arias. https://novaresearch.unl.pt/en/publications/b3cff4d2-a5ff-4c15-8cc0-fe6eb1b24644.
  2. Butirato, ¿Un compuesto tóxico para nuestro organismo?. 2017. Alejandro K. Samhan Arias. https://unl.elsevierpure.com/en/publications/d84e9951-0f2c-44df-9a32-bed834c74d26.
  3. Microbiota importance for life. Importancia de la microbiota para la vida. 2017. Alejandro K. Samhan Arias. https://unl.elsevierpure.com/en/publications/839ddb61-165b-4433-8172-aaac3f975b5a.
Activities

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/09/05 - Current Introduction to research in Biomedicine 1st course of the Grade in Medicine (Graduado) Universidad Autónoma de Madrid Departamento de Bioquímica, Spain
2020/09/05 - Current CRITICAL ANALYSIS OF SCIENTIFIC LITERATURE (CASL). Máster en Biotecnología (Master) Universidad Autónoma de Madrid Departamento de Bioquímica, Spain
2020/09/05 - Current General Biochemistry 1st course of the Bachelor's Degree in Nursing (Bachelor) Universidad Autónoma de Madrid Departamento de Bioquímica, Spain
2020/02 - Current HUMAN BIOCHEMISTRY AND BIOPHYSICS 2nd course of Medicine degree (Graduado) Universidad Autónoma de Madrid Facultad de Medicina, Spain
2020/09/05 - 2021/07/11 Biochemistry and Molecular Biology 1st course of the Grade in Medicine (Graduado) Universidad Autónoma de Madrid Departamento de Bioquímica, Spain

Journal scientific committee

Journal title (ISSN) Publisher
2014/01/01 - Current Several. Please see the Metric on link Several
Distinctions

Award

2008 PhD. Thesis Award in the Biomedical Field
Universidad de Extremadura, Spain
2007 Young Investigator Award-Society for Free Radical Research