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João Pedro Marante António. Completed the Doutoramento in Farmácia in 2020/05 by Universidade de Lisboa Faculdade de Farmácia and Mestrado in Mestrado Integrado em Ciências Farmacêuticas in 2014/12 by Universidade de Lisboa Faculdade de Farmácia. Is Researcher in Universidade de Lisboa Faculdade de Farmácia. Published 13 articles in journals. Has 1 book(s). Organized 3 event(s). Co-supervised 3 MSc dissertation(s). Has received 3 awards and/or honors. Participates and/or participated as PhD Student Fellow in 3 project(s), Post-doc Fellow in 2 project(s) and Research Fellow in 1 project(s). In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Mestrado Integrado - 2014; Raman spectroscopy; SERS; Bisphenol; Ciências da Saúde; .
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Identification

Personal identification

Full name
João Pedro Marante António

Citation names

  • António, João P. M.

Author identifiers

Ciência ID
FA1D-861A-FEA2
ORCID iD
0000-0002-0144-694X
Scopus Author Id
56263435200

Email addresses

  • jantonio@ff.ulisboa.pt (Professional)

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Advanced (C1) Proficiency (C2) Proficiency (C2)
French Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1)
Education
Degree Classification
2016/01 - 2020/05
Concluded
 Farmácia (Doutoramento)
Major in Especialidade: Química Farmacêutica e Terapêutica
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Cysteins functionalization in the synthesis of complex and well-defined bioconjugates " (THESIS/DISSERTATION)
2009/09 - 2014/12
Concluded
 Mestrado Integrado em Ciências Farmacêuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Development of an analytical method for the simultaneous detection of bisphenols using a Surface-enhanced Raman scattering quantitative approach" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2023/03 - Current Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/05 - 2023/03 Postdoc (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/09 - 2022/04 Postdoc (Research) École nationale supérieure de chimie de Paris, France
École nationale supérieure de chimie de Paris, France
(...)
Projects

Grant

Designation Funders
2023/03 - 2029/03 Boronated Azines: A new generation of versatile, readily-accessible and highly-efficient photosensitizers for photodynamic therapy in oncology
8090EEC
 Fundação para a Ciência e a Tecnologia
2022/05/15 - 2023/03/15 SmartBox: Desenvolvimento da primeira geração de ADCs sensíveis a ROS
Provided by PTCRIS: PTDC/QUI-OUT/3989/2021
Post-doc Fellow
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07 - 2022/07 Plataformas Boronadas Citotóxicas Multivalentes - Um Novo Conceito para Combater o Cancro
151160PRJ
 Fundação para a Ciência e a Tecnologia
2020/09 - 2021/09 Therapeutic Application of Ruthenium-containing Polymers for Ovarian Cancers
17-CONV-0005
Post-doc Fellow
École nationale supérieure de chimie de Paris, France
Concluded
2019/01 - 2019/12 Instituto de Investigação do Medicamento
154706UID
 Fundação para a Ciência e a Tecnologia
2017/01 - 2019/12 Cysteine functionalization in the synthesis of complex and well-defined bioconjugates
Provided by PTCRIS: PD/BD/128239/2016
PhD Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017/01 - 2019/12 Cysteine functionalization in the synthesis of complex and well-defined bioconjugates
59776DFA
 Fundação para a Ciência e a Tecnologia
2016/01 - 2016/12 MedChemTrain Doctoral Program
Provided by PTCRIS: PD/BI/114155/2016
PhD Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/01 - 2016/12 1º ano do PD
54060DFA
 Fundação para a Ciência e a Tecnologia
2015/04 - 2015/10 Síntese eficiente de carbociclos e avaliação biológica
Provided by PTCRIS: PTDC/QUI-QUI/119823/2010
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2018/07 - 2022/07 Plataformas Boronadas Citotóxicas Multivalentes - Um Novo Conceito para Combater o Cancro
Provided by PTCRIS: PTDC/QUI-QOR/29967/2017
PhD Student Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
2019/01/01 - 2019/12/31 Research Institute for Medicines
UID/DTP/04138/2019
Centro de Estudos de Recursos Naturais Ambiente e Sociedade, Portugal

Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Antonio, J.P.M.; Farias, G.D.V.; Santos, F.M.F.; Oliveira, R.; Cal, P.M.S.D.; Gois, P.M.P.. Boron-Nitrogen Bond: A Useful Molecular Construction Tool. 2016.
    10.1002/9781119113874.ch2
Journal article
  1. Silva, Maria J. S. A.; Zhang, Yiyi; Vinck, Robin; Santos, Fábio M. F.; António, João P. M.; Gourdon-Grünewaldt, Lisa; Zaouter, Charlotte; et al. "BASHY Dyes Are Highly Efficient Lipid Droplet-Targeting Photosensitizers that Induce Ferroptosis through Lipid Peroxidation". Bioconjugate Chemistry 34 12 (2023): 2337-2344. http://dx.doi.org/10.1021/acs.bioconjchem.3c00449.
    10.1021/acs.bioconjchem.3c00449
  2. Sofia Monteiro; Pedro Gois; João António. "Boronic Acids and Beyond: ROS-responsive prodrugs as tools for a safer and more effective cancer chemotherapy". Synlett (2023): https://doi.org/10.1055/a-2132-1356.
    10.1055/a-2132-1356
  3. João Franco Machado; Fernanda Marques; Teresa Pinheiro; Maria J. Villa de Brito; Gonzalo Scalese; Leticia Pérez-Díaz; Lucía Otero; et al. "Copper(I)-Thiosemicarbazone Complexes with Dual Anticancer and Antiparasitic Activity". ChemMedChem (2023): http://dx.doi.org/10.1002/cmdc.202300074.
    10.1002/cmdc.202300074
  4. André, Ana S.; Dias, Joana N. R.; Aguiar, Sandra; Nogueira, Sara; Bule, Pedro; Carvalho, Joana Inês; António, João P. M.; et al. "Rabbit derived VL single-domains as promising scaffolds to generate antibody–drug conjugates". Scientific Reports 13 1 (2023): 4837. http://dx.doi.org/10.1038/s41598-023-31568-x.
    10.1038/s41598-023-31568-x
  5. João P. M. António; Albert Gandioso; Fariba Nemati; Nancy Soliman; Robin Vinck; Fan Sun; Carine Robert; et al. "Polymeric encapsulation of a ruthenium(ii) polypyridyl complex: from synthesis to in vivo studies against high-grade epithelial ovarian cancer". Chemical Science (2023): https://doi.org/10.1039/D2SC05693C.
    10.1039/D2SC05693C
  6. Padanha, R.; Cavadas, R.A.N.; Merino, P.; António, J.P.M.; Gois, P.M.P.. "N-Terminal Cysteine Bioconjugation with (2-Cyanamidophenyl)boronic Acids Enables the Direct Formation of Benzodiazaborines on Peptides". Organic Letters 25 29 (2023): 5476-5480. http://www.scopus.com/inward/record.url?eid=2-s2.0-85166362275&partnerID=MN8TOARS.
    10.1021/acs.orglett.3c01835
  7. Afonso, C.F.; Marques, M.C.; António, J.P.M.; Cordeiro, C.; Gois, P.M.P.; Cal, P.M.S.D.; Bernardes, G.J.L.. "Cysteine-Assisted Click-Chemistry for Proximity-Driven, Site-Specific Acetylation of Histones". Angewandte Chemie - International Edition 61 46 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85140124608&partnerID=MN8TOARS.
    10.1002/anie.202208543
  8. João P. M. António; Hélio Faustino; Pedro M. P. Gois. Corresponding author: João P. M. António. "A 2-formylphenylboronic acid (2FPBA)-maleimide crosslinker: a versatile platform for Cys-peptide–hydrazine conjugation and interplay". Organic & Biomolecular Chemistry (2021): https://doi.org/10.1039/D1OB00917F.
    10.1039/D1OB00917F
  9. António, J.P.M.; Carvalho, J.I.; André, A.S.; Dias, J.N.R.; Aguiar, S.I.; Faustino, H.; Lopes, R.M.R.M.; et al. "Diazaborines Are a Versatile Platform to Develop ROS-Responsive Antibody Drug Conjugates**". Angewandte Chemie - International Edition 60 49 (2021): 25914-25921. http://www.scopus.com/inward/record.url?eid=2-s2.0-85118481878&partnerID=MN8TOARS.
    10.1002/anie.202109835
  10. João P. M. António; Filipa Ramilo-Gomes; Maria Inês P. Mendes; Rafael F. A. Gomes. "MedChemTrain e-School 2020: Event Highlights and Insights into Virtual Symposium Organization". ChemMedChem 15 24 (2020): 2562-2568. https://doi.org/10.1002/cmdc.202000450.
    10.1002/cmdc.202000450
  11. Pereira, J.G.; António, J.P.M.; Mendonça, R.; Gomes, R.F.A.; Afonso, C.A.M.. "Rediscovering aminal chemistry: Copper(ii) catalysed formation under mild conditions". Green Chemistry 22 21 (2020): 7484-7490. http://www.scopus.com/inward/record.url?eid=2-s2.0-85096046972&partnerID=MN8TOARS.
    10.1039/d0gc01977a
  12. João P. M. António; Roberto Russo; Cátia Parente Carvalho; Pedro M. S. D. Cal; Pedro M. P. Gois. "Boronic acids as building blocks for the construction of therapeutically useful bioconjugates". Chemical Society Reviews (2019): https://doi.org/10.1039/C9CS00184K.
    10.1039/C9CS00184K
  13. Siopa, F.; António, J.P.M.; Afonso, C.A.M.. "Flow-Assisted Synthesis of Bicyclic Aziridines via Photochemical Transformation of Pyridinium Salts". Organic Process Research and Development 22 4 (2018): 551-556. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045849984&partnerID=MN8TOARS.
    10.1021/acs.oprd.8b00036
  14. António, J.P.M.; Gonçalves, L.M.; Guedes, R.C.; Moreira, R.; Gois, P.M.P.. "Diazaborines as New Inhibitors of Human Neutrophil Elastase". ACS Omega 3 7 (2018): 7418-7423. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049642953&partnerID=MN8TOARS.
    10.1021/acsomega.8b00702
  15. António, J.P.M.; Frade, R.F.M.; Santos, F.M.F.; Coelho, J.A.S.; Afonso, C.A.M.; Gois, P.M.P.; Trindade, A.F.. "NHC catalysed direct addition of HMF to diazo compounds: Synthesis of acyl hydrazones with antitumor activity". RSC Advances 4 55 (2014): 29352-29356. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904087990&partnerID=MN8TOARS.
    10.1039/c4ra03710c
Magazine article
  1. João P. M. António; Alexandre Trindade; Rafael F. A. Gomes; Jaime Coelho; Raquel Frade; Carlos Afonso. "5-hidroximetilfurfural: plataforma para obtenção de diversidade molecular", Química, 2018
Thesis / Dissertation
  1. António, João Pedro Marante. "Development of an analytical method for the simultaneous detection of bisphenols using a Surface-enhanced Raman scattering quantitative approach". Master, 2014. http://hdl.handle.net/10451/26755.

Other

Other output
  1. Polymeric Encapsulation of a Ruthenium(II) Polypyridyl Complex: From Synthesis to in vivo Studies against High-Grade Epithelial Ovarian Cancer. 2022. Gasser, G.; António, J.P.M.; Gandioso, A.; Nemati, F.; Soliman, N.; Vinck, R.; Sun, F.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85144761843&partnerID=MN8TOARS.
    10.26434/chemrxiv-2022-2kbj5
  2. Development of Diazaborines as ROS Sensitive Linkers for the Construction of Stimuli-Responsive Antibody Drug Conjugates. 2021. Gois, P.M.P.; António, J.P.M.; Carvalho, J.I.; André, A.S.; Dias, J.N.R.; Faustino, H.; Lopes, R.M.R.M.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85126494608&partnerID=MN8TOARS.
    10.26434/chemrxiv-2021-qh8zd
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/06 Diazaborines as a stable and triggerable linker: The development of the first well-defined ROS-responsive antibody-drug conjugate 5th Encounter of the College of Chemistry of Universidade de Lisboa
(Lisbon, Portugal)
2022/04 Diazaborines as stable and ROS-responsive linkers: The dawn of a new generation of Antibody-Drug Conjugates 14º ENQO & 7º ENQT of the Portuguese Chemical Society
(Caparica, Portugal)
2021/04 Preparation and evaluation of Ruthenium-loaded polymeric nanoparticles PSL-Qlife Annual Meeting 2021
(France)
2021 Polymeric nanoencapsulation of cytotoxic Ruthenium(II) polypyridyl complexes for tumor delivery i-CleHS Symposium
(France)
2019 A new life for Diazaborines: The next generation of serine protease inhibitors EFMC-YMCS’19
(Greece)
2018 A new life for Diazaborines: The next generation of serine protease inhibitors 10th iMed.ULisboa Postgraduate Students Meeting
(Portugal)
2018 Diazaborines: Boronic acids under disguise for selective inhibition of Human Neutrophil Elastase 6th Portuguese Young Chemists Meeting (PYChem)
(Portugal)
2017 A protective group for boronic acids that selectively inhibit Human Neutrophil Elastase 2nd Encounter of the College of Chemistry of the Lisbon University
(Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/09 - Current Design of innovative ROS-responsive antibody-drug conjugates
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/05 - 2022/09 Targeting tumour cells using chemical linkers with boronic acids and diazaborine scaffolds
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/01 - 2021/06 Design of a light-activated antibacterial surface through Ruthenium-initiated polymerization of lactide
Co-supervisor
École nationale supérieure de chimie de Paris, France

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020 - 2020 MedChemTrain e-School 2020 (2020 - 2020)
Congress (President of the Organising Committee)
2017 - 2017 XXV National Meeting of the Portuguese Chemistry Society (2017 - 2017)
Congress (Member of the Organising Committee)
2013 - 2013 10th National Organic Chemistry Meeting of the Portuguese Chemistry Society (2013 - 2013)
Congress (Member of the Organising Committee)

Journal scientific committee

Journal title (ISSN) Publisher
2022/02 - 2022/02 Metallomics (1756-5901) Royal Society of Chemistry/ Oxford University Press
2022 - 2022 The Chemical Record (1528-0691) John Wiley & Sons Inc.
Distinctions

Award

2022 Best oral presentation at the 5th Encounter of the College of Chemistry of Universidade de Lisboa

Other distinction

2023 Junior Researcher position
Fundação para a Ciência e a Tecnologia, Portugal
2014 Erasmus Grant nr 179/SMS/2013
Universidade de Lisboa, Portugal