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Identification

Personal identification

Full name
Diana Rita Barata Costa

Author identifiers

Ciência ID
FA1D-8901-2ED6

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2023/06/22 - 2023/06/23
Concluded
 Horizon Europe Training (Outros)
Universidade da Beira Interior, Portugal
2009/02/19
Concluded
 Quimica Macromolecular (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Covalent DNA Gels: Synthesis, Swelling and Release Properties" (THESIS/DISSERTATION)
 Aprovada com Distinção e Louvor
2007/10/01 - 2007/11/30
Concluded
 Chemistry/Physics of Life Processes (Postgraduate Certificate)
Major in Chemistry/Physics
Karl Franzens Universität Institut für Erdwissenschaften, Austria
 18 (0-20 score)
2003/08/01 - 2003/08/30
Concluded
 Surfactants and Polymers in Aqueous Solution (Postgraduate Certificate)
Major in Physical Chemistry
Physical Chemistry Department 1,University of Lund, Sweden, Sweden
 19 (0-20 score)
2003
Concluded
 Química (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Interacção entre ADN e Catiões em gel e em solução" (THESIS/DISSERTATION)
 Bom-15 valores.
Affiliation

Science

Category
Host institution 		Employer
2017/01/01 - Current Auxiliary Researcher (Research) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2023/12/11 - 2023/12/15 Visiting Researcher (Research) Université du Luxembourg Département Sciences de la Vie et Médecine, Luxembourg
Université du Luxembourg Département Sciences de la Vie et Médecine, Luxembourg
2023/11/06 - 2023/11/10 Visiting Researcher (Research) Universidad de Zaragoza - Campus Río Ebro, Spain
Universidad de Zaragoza - Campus Río Ebro, Spain
2023/02/27 - 2023/03/03 Visiting Researcher (Research) Universidad de Salamanca, Spain
Universidad de Salamanca, Spain
2023/01/18 - 2023/01/20 Visiting Researcher (Research) Universidad de Zaragoza, Spain
Universidad de Zaragoza Facultad de Ciencias, Spain
2016/05/01 - 2016/05/29 Visiting Researcher (Research) Midwestern University College of Pharmacy - Glendale, United States
Midwestern University College of Pharmacy - Glendale, United States
2009/09/01 - 2015/12/30 Postdoc (Research) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2014/07/14 - 2014/08/01 Visiting Researcher (Research) School of Chemistry, University of Bristol, UK, United Kingdom
School of Chemistry, University of Bristol, UK, United Kingdom
2010/05/01 - 2010/08/30 Postdoc (Research) Nanobiotechnology Center,Cornell University, New York, EUA, United States
Nanobiotechnology Center,Cornell University, New York, EUA, United States
2009/10/01 - 2009/11/30 Visiting Researcher (Research) Department of Chemistry, University of Burgos, Spain, Spain
Department of Chemistry, University of Burgos, Spain, Spain
2004/12/01 - 2009/01/01 Researcher (Research) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2007/10/01 - 2007/12/31 Contracted Researcher (Research) Institut für Chemie, Physical Chemistry Department, Graz University, Graz, Austria, Austria
Institut für Chemie, Physical Chemistry Department, Graz University, Graz, Austria, Austria
2003/09/01 - 2003/10/30 Visiting Researcher (Research) Pharmacy Department, University of Uppsala, Sweden, Sweden
Pharmacy Department, University of Uppsala, Sweden, Sweden
2003/09/24 - 2003/09/26 Visiting Researcher (Research) Physical Chemistry Department, University of Chalmers, Gotemburgo, Sweden, Sweden
Physical Chemistry Department, University of Chalmers, Gotemburgo, Sweden, Sweden
2003/03/01 - 2003/06/30 Visiting Researcher (Research) Physical Chemistry Department 1,University of Lund, Sweden, Sweden
Physical Chemistry Department 1,University of Lund, Sweden, Sweden

Teaching in Higher Education

Category
Host institution 		Employer
2021/10/01 - Current Invited Assistant Professor (University Teacher) Universidade da Beira Interior, Portugal
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2023/03/06 - 2023/03/07 Visiting Professor (University Teacher) Universidad de Valladolid, Spain
Universidad de Valladolid, Spain
2020/06/01 - 2020/06/12 Invited Assistant Professor (University Teacher) Metropolitan State University of Denver School of Letters Arts and Sciences, United States
Metropolitan State University of Denver School of Letters Arts and Sciences, United States
2015/01/01 - 2015/01/30 Invited Assistant Professor (University Teacher) School of Chemistry, University of Bristol, UK, United Kingdom
School of Chemistry, University of Bristol, UK, United Kingdom

Positions / Appointments

Category
Host institution 		Employer
2001/07/01 - 2001/09/15 assistente de laboratório Instituto Português da Qualidade, Portugal
Instituto Português da Qualidade, Portugal

Others

Category
Host institution 		Employer
2009/09/01 - Current Integrated member from the Health Science Research Center (CICS) Universidade da Beira Interior, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015/10/01 - 2016/12/31 Bolsa Pós-Doutoramento (SFRH /BPD/ 103592 /2014) Fundação para a Ciência e a Tecnologia, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2009/09/01 - 2015/09/01 Bolsa Pós-Doutoramento (SFRH/BPD/47229/2008) Fundação para a Ciência e a Tecnologia, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015/04/01 - 2015/06/30 Consultor Científico Elan Pharmaceuticals Company, Ireland
Elan Pharmaceuticals Company, Ireland
2004/12/01 - 2008/12/01 Bolsa Doutoramento (SFRH/BD/16736/2004) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra, Portugal
Projects

Contract

Designation Funders
2023/04/01 - Current NanoINTer: Functionalized DNA Nanovaccine for Cervical Cancer Immunotherapy
NanoINTer
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Ongoing
2023/03/01 - Current MIND: Multifunctional Innovative NanoDevice for lung cancer therapy
MIND
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Universidade da Beira Interior
Ongoing
2017/01/01 - 2021/12/31 Gene Therapy for Mitochondrial DNA disease: Development of a mitochondrial-targeted vector.
IF/01459/2015
Principal investigator
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/04/01 - 2020/03/31 Interdisciplinary Challenges On Neurodegeneration (ICON), Programa Operacional Regional do Centro (CENTRO-01-0145-FEDER-000013).
ICON Project (Interdisciplinary Challenges on Neurodegeneration; CENTRO-01-0145-FEDER-000013)
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro
Ongoing
2011/03/01 - 2014/08/31 Isolation and Purification of Plasmid DNA for Cancer Therapy
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/114320/PT
Researcher
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2008/01/01 - 2010/12/31 Polyelectrolyte organization and properties: gels, membranes and particles
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/67962/PT
Researcher
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2003/07/30 - 2007/07/30 Self-assembled nanosystems: DNA packaging and novel gels
info:eu-repo/grantAgreement/FCT/POCI/45344/PT
Research Fellow
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Ana R. Neves; Albuquerque, Tânia; Eusébio, Dalinda; Sousa, Ângela; Costa, Diana. Corresponding author: Costa, Diana. "Challenges and future perspectives of natural biopolymers in drug delivery". In Natural Biopolymers for Drug Delivery. Elsevier, 2024.
    In press
  2. Costa, Diana. Corresponding author: Costa, Diana. "Calcium phosphate nanoparticles in therapeutics". In Inorganic Nanosystems: Theranostic Nanosystems, Volume 2. Elsevier, 2023.
    Published
  3. Costa, Diana. "Nanoconjugates and nanoconjugate formulations for improving drug delivery and therapeutic efficacy". In Advanced nanoformulations, Theranostic Nanosystems, Volume 3. Elsevier, 2023.
    Published
  4. Neves, Ana R.; Faria, Rúben; Biswas, Swati; Costa, Diana. "Plant polysaccharides in formulation coating". In Plant Polysaccharides as Pharmaceutical Excipients, edited by Dr. Amit Kumar Nayak; Md Saquib Hasnain; Dr. Dilipkumar Pal, 391-413. Elsevier, 2023.
    Published • 10.1016/b978-0-323-90780-4.00010-3
  5. Neves, Ana R.; Faria, Rúben; Albuquerque, Tânia; Quintela, Telma; Sousa, Ângela; Costa, Diana. "Future perspectives of biological macromolecules in biomedicine". In Biological Macromolecules, 607-632. Elsevier, 2022.
    Published • 10.1016/b978-0-323-85759-8.00026-9
  6. Costa, Diana. Corresponding author: Costa, Diana. "Bio-inspired drug delivery therapeutics". In Recent and Future Trends in Pharmaceutics. Elsevier, 2022.
    Under revision
  7. Costa, Diana. "Gellan gum microspheres and their applications in the biomedical industry". In Gellan Gum as Biomedical Polymer. Elsevier, 2022.
    Under revision
  8. Costa, Diana. "Gellan Gum-Based Biomedical Gels". In Gellan Gum as Biomedical Polymer. Elsevier, 2022.
    Under revision
  9. Costa, Diana. Corresponding author: Costa, Diana. "Drug delivery for bone tissue engineering". In ADVANCED AND MODERN APPROACHES FOR DRUG DELIVERY. Elsevier, 2022.
    In press
  10. Albuquerque, Tânia; Neves, Ana Raquel; Faria, Rúben; Quintela, Telma; Costa, Diana. Corresponding author: Costa, Diana. "Chronobiology and Nanotechnology for Personalized Cancer Therapy". In Cancer Nanotechnology, 205-227. Springer International Publishing, 2022.
    Published • 10.1007/978-3-031-17831-3_7
  11. Faria, Rúben; Albuquerque, Tânia; Neves, Ana Raquel; Sousa, Ângela; Costa, Diana Rita Barata. "Nanotechnology to Correct Mitochondrial Disorders in Cancer Diseases". In Cancer Nanotechnology, 179-203. Springer International Publishing, 2022.
    Published • 10.1007/978-3-031-17831-3_6
  12. Costa, Diana; Sousa, Ângela; Faria, Rúben; Neves, Ana Raquel; Queiroz, João A.. Corresponding author: Costa, Diana. "Conception of Plasmid DNA and Polyethylenimine Delivery Systems with Potential Application in DNA Vaccines Field". In Methods in Molecular Biology, 271-284. United States: Springer US, 2021.
    Published • 10.1007/978-1-0716-0872-2_15
  13. Costa, Diana; de Sousa, Fani Pereira; de Sampaio Rodrigues Queiroz, João António. Corresponding author: Costa, Diana. "Development of plasmid DNA nanoparticles for mitochondrial gene therapy". In Materials for Biomedical Engineering, 297-327. United States: Elsevier, 2019.
    Published • 10.1016/b978-0-12-818435-6.00011-6
  14. Costa, Diana. Corresponding author: Costa, Diana. "DNA based hydrogels: an approach for multifunctional bio-applications". In Gels Horizons: From Science to Smart Materials, Hydrogels: Recent Advances. Springer Singapore, 2018.
    Published • 10.1007/978-981-10-6077-9
  15. Costa, Diana; Valente, Artur J.M.; Queiroz, João. Corresponding author: Costa, Diana. "Responsive Plasmid DNA Hydrogels: A New Approach for Biomedical Applications". In Handbook of Polymers for Pharmaceutical Technologies, 145-162. John Wiley & Sons, Inc., 2015.
    Published • 10.1002/9781119041559.ch6
  16. Morán, M; Costa, Diana; da Graça, Maria; Lindman, Björn. Corresponding author: Costa, Diana. "DNA Release from Cross-Linked DNA Gels and DNA Gel Particles". In Surfactant Science and Technology, 233-250. CRC Press, 2014.
    Published • 10.1201/b16802-12
  17. Costa, Diana. "DNA-Surfactant Systems: Particles, Gels and Nanostructures". In Nano-Science: Colloidal Background. Taylor & Frances, 2010.
    Published
  18. Lindman, Björn; Dias, Rita S.; Miguel, M. da Graça; Morán, M. Carmen; Costa, Diana. Corresponding author: Costa, Diana. "Manipulation of DNA by Surfactants". In Highlights in Colloid Science, edited by Dimo Platikanov; Dotchi Exerowa, 179-202. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
    Published • 10.1002/9783527623884.ch10
  19. Costa, Diana; Moran, M. Carmen; Miguel, Maria da Graça; Lindman, Björn. Corresponding author: Costa, Diana. "Cross-Linked DNA Gels and Gel Particles". In DNA Interactions with Polymers and Surfactants, edited by Rita Sousa Dias; Bjorn Lindman, 353-365. New York, United States: John Wiley & Sons, Inc., 2008.
    Published • 10.1002/9780470286364.ch14
  20. Costa, Diana. Corresponding author: Costa, Diana. "Covalent DNA gels: Effect of DNA conformation". In Colloids and Interfaces (RICI 2), edited by Artur José Monteiro Valente; Sérgio Seixas de Melo. Lisboa, Portugal: Sociedade Portuguesa de Química, 2007.
    Published
Conference poster
  1. Eusébio, Dalinda; Ventura, Cathy; Gonçalves, Ana M.; Barroca-Ferreira, Jorge; Costa, Diana; Cui, Zhengrong; Passarinha, Luís A.; Sousa, Ângela. "Optimization of the minicircle DNA vaccine expressing SARS-CoV-2 RBD production using orbital shaker experiments and a mini-bioreactor platform". Paper presented in IV International Congress on Health Sciences Research Towards Innovation and Entrepreneurship - Challenges from Research to Clinics, 2023.
  2. Eusébio, Dalinda; Paul, Milan; Biswas, Swati; Cui, Zhengrong; Costa, Diana; Sousa, Ângela. "Multifunctional nanoparticles for targeted delivery of minicircle DNA vaccine against COVID-19 to antigen-presenting cells". Paper presented in XVII International CICS-UBI Symposium, 2022.
Journal article
  1. Rafael Mineiro; Tânia Albuquerque; Ana Raquel Neves; Cecília R. A. Santos; Diana Costa; Telma Quintela. "The Role of Biological Rhythms in New Drug Formulations to Cross the Brain Barriers". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241612541.
    10.3390/ijms241612541
  2. Tânia Albuquerque; Ana Raquel Neves; Milan Paul; Swati Biswas; Elena Vuelta; Ignacio García-Tuñón; Manuel Sánchez-Martin; Telma Quintela; Diana Costa. Corresponding author: Diana Costa. "A Potential Effect of Circadian Rhythm in the Delivery/Therapeutic Performance of Paclitaxel–Dendrimer Nanosystems". Journal of Functional Biomaterials (2023): https://doi.org/10.3390/jfb14070362.
    10.3390/jfb14070362
  3. Ferreira, Miguel; Gomes, Diana; Neto, Miguel; Passarinha, Luís A.; Costa, Diana; Sousa, Ângela. "Development and Characterization of Quercetin-Loaded Delivery Systems for Increasing Its Bioavailability in Cervical Cancer Cells". Pharmaceutics 15 3 (2023): 936. http://dx.doi.org/10.3390/pharmaceutics15030936.
    Open access • Published • 10.3390/pharmaceutics15030936
  4. Faria, Rúben; Boisguérin, Prisca; Sousa, Ângela; Costa, Diana. Corresponding author: Costa, Diana. "Delivery Systems for Mitochondrial Gene Therapy: A Review". Pharmaceutics 15 2 (2023): 572. http://dx.doi.org/10.3390/pharmaceutics15020572.
    Open access • Published • 10.3390/pharmaceutics1502057
  5. Costa, Diana. Corresponding author: Costa, Diana. "Development of WRAP5 Peptide Complexes for Targeted Drug/Gene Co-Delivery toward Glioblastoma Therapy". Pharmaceutics 14 (2022): 2213. https://doi.org/10.3390/pharmaceutics14102213.
    Open access • Published
  6. Neves, Ana R.; Albuquerque, Tânia; Quintela, Telma; Costa, Diana. Corresponding author: Costa, Diana. "Circadian rhythm and disease: Relationship, new insights, and future perspectives". Journal of Cellular Physiology 237 8 (2022): 3239-3256. http://dx.doi.org/10.1002/jcp.30815.
    Published • 10.1002/jcp.30815
  7. Ferreira, Miguel; Costa, Diana; Sousa, Ângela. "Flavonoids-Based Delivery Systems towards Cancer Therapies". Bioengineering 9 5 (2022): 197. http://dx.doi.org/10.3390/bioengineering9050197.
    Open access • Published • 10.3390/bioengineering9050197
  8. Ventura, Cathy; Eusébio, Dalinda; Gonçalves, Ana M.; Barroca-Ferreira, Jorge; Costa, Diana; Cui, Zhengrong; Passarinha, Luís A.; Sousa, Ângela. "Maximization of the Minicircle DNA Vaccine Production Expressing SARS-CoV-2 RBD". Biomedicines 10 5 (2022): 990. http://dx.doi.org/10.3390/biomedicines10050990.
    Open access • Published • 10.3390/biomedicines10050990
  9. Faria, Rúben; Paul, Milan; Biswas, Swati; Vivès, Eric; Boisguérin, Prisca; Sousa, Ângela; Costa, Diana. Corresponding author: Costa, Diana. "Peptides vs. Polymers: Searching for the Most Efficient Delivery System for Mitochondrial Gene Therapy". Pharmaceutics 14 4 (2022): 757. http://dx.doi.org/10.3390/pharmaceutics14040757.
    Open access • Published • 10.3390/pharmaceutics14040757
  10. Albuquerque, Tânia; Neves, Ana R.; Quintela, Telma; Costa, Diana. Corresponding author: Costa, Diana. "The Influence of Circadian Rhythm on Cancer Cells Targeting and Transfection Efficiency of a Polycation-Drug/Gene Delivery Vector". Polymers 14 4 (2022): 681. http://dx.doi.org/10.3390/polym14040681.
    Open access • Published • 10.3390/polym14040681
  11. Gomes, D.; Costa, D.; Queiroz, J.A.; Passarinha, L.A.; Sousa, A.. "A new insight in gellan microspheres application to capture a plasmid DNA vaccine from an Escherichia coli lysate". Separation and Purification Technology 274 (2021): 119013. http://dx.doi.org/10.1016/j.seppur.2021.119013.
    Published • 10.1016/j.seppur.2021.119013
  12. Eusébio, Dalinda; Neves, Ana R.; Costa, Diana; Biswas, Swati; Alves, Gilberto; Cui, Zhengrong; Sousa, Ângela. "Methods to improve the immunogenicity of plasmid DNA vaccines". Drug Discovery Today 26 11 (2021): 2575-2592. http://dx.doi.org/10.1016/j.drudis.2021.06.008.
    Open access • Published • 10.1016/j.drudis.2021.06.008
  13. Costa, Diana. Corresponding author: Costa, Diana. "Development of Tailor-Made Dendrimer Ternary Complexes for Drug/Gene Co-Delivery in Cancer". Pharmaceutics 13 (2021): 1256.
    Open access • Published
  14. Rodolfo, Carlos; Eusébio, Dalinda; Ventura, Cathy; Nunes, Renato; Florindo, Helena F.; Costa, Diana; Sousa, Ângela. "Design of Experiments to Achieve an Efficient Chitosan-Based DNA Vaccine Delivery System". Pharmaceutics 13 9 (2021): 1369. http://dx.doi.org/10.3390/pharmaceutics13091369.
    Open access • Published • 10.3390/pharmaceutics13091369
  15. Albuquerque, Tânia; Neves, Ana R.; Quintela, Telma; Costa, Diana. Corresponding author: Costa, Diana. "Exploring the link between chronobiology and drug delivery: effects on cancer therapy". Journal of Molecular Medicine (2021): http://dx.doi.org/10.1007/s00109-021-02106-x.
    Open access • Published • 10.1007/s00109-021-02106-x
  16. Faria, Rúben; Vivés, Eric; Boisguerin, Prisca; Sousa, Angela; Costa, Diana. Corresponding author: Costa, Diana. "Development of Peptide-Based Nanoparticles for Mitochondrial Plasmid DNA Delivery". Polymers 13 11 (2021): 1836. http://dx.doi.org/10.3390/polym13111836.
    Open access • Published • 10.3390/polym13111836
  17. Serra, Ana Sofia; Eusébio, Dalinda; Neves, Ana Raquel; Albuquerque, Tânia; Bhatt, Himanshu; Biswas, Swati; Costa, Diana; Sousa, Ângela. "Synthesis and Characterization of Mannosylated Formulations to Deliver a Minicircle DNA Vaccine". Pharmaceutics 13 5 (2021): 673. http://dx.doi.org/10.3390/pharmaceutics13050673.
    Published • 10.3390/pharmaceutics13050673
  18. Almeida, Ana M.; Costa, Diana; Simões, Ana R.; Queiroz, João A.; Sousa, Fani; Sousa, Ângela. "Enhancement of a biotechnological platform for the purification and delivery of a human papillomavirus supercoiled plasmid DNA vaccine". New Biotechnology (2020): http://dx.doi.org/10.1016/j.nbt.2020.04.003.
    Published • 10.1016/j.nbt.2020.04.003
  19. Faria, Rúben; Albuquerque, Tânia; Neves, Ana R.; Bhatt, Himanshu; Biswas, Swati; Cardoso, Ana M.; Pedroso de Lima, Maria C.; Jurado, Amália S.; Costa, Diana. Corresponding author: Costa, Diana. "Physicochemical characterization and targeting performance of triphenylphosphonium nano-polyplexes". Journal of Molecular Liquids (2020): 113873. http://dx.doi.org/10.1016/j.molliq.2020.113873.
    Published • 10.1016/j.molliq.2020.113873
  20. Albuquerque, Tânia; Faria, Rúben; Sousa, Ângela; Neves, Ana R.; Queiroz, João A.; Costa, Diana. Corresponding author: Costa, Diana. "Polymer-peptide ternary systems as a tool to improve the properties of plasmid DNA vectors in gene delivery". Journal of Molecular Liquids 309 (2020): 113157. http://dx.doi.org/10.1016/j.molliq.2020.113157.
    Published • 10.1016/j.molliq.2020.113157
  21. Sousa, Ângela; Faria, Rúben; Albuquerque, Tânia; Bhatt, Himanshu; Biswas, Swati; Queiroz, João A.; Costa, Diana. Corresponding author: Costa, Diana. "Design of experiments to select triphenylphosphonium-polyplexes with suitable physicochemical properties for mitochondrial gene therapy". Journal of Molecular Liquids (2020): 112488. http://dx.doi.org/10.1016/j.molliq.2020.112488.
    Published • 10.1016/j.molliq.2020.112488
  22. Neves, A.R.; Sousa, A.; Faria, R.; Albuquerque, T.; Queiroz, J.A.; Costa, Diana. Corresponding author: Costa, Diana. "Cancer gene therapy mediated by RALA/plasmid DNA vectors: Nitrogen to phosphate groups ratio (N/P) as a tool for tunable transfection efficiency and apoptosis". Colloids and Surfaces B: Biointerfaces 185 (2020): 110610. http://dx.doi.org/10.1016/j.colsurfb.2019.110610.
    Open access • Published • 10.1016/j.colsurfb.2019.110610
  23. Sousa, Ângela; Almeida, Ana M.; Faria, Rúben; Konate, Karidia; Boisguerin, Prisca; Queiroz, João A.; Costa, Diana. Corresponding author: Costa, Diana. "Optimization of peptide-plasmid DNA vectors formulation for gene delivery in cancer therapy exploring design of experiments". Colloids and Surfaces B: Biointerfaces 183 (2019): 110417. http://dx.doi.org/10.1016/j.colsurfb.2019.110417.
    Published • 10.1016/j.colsurfb.2019.110417
  24. Faria, Rúben; Sousa, Ângela; Neves, Ana R.; Queiroz, João A.; Costa, Diana. Corresponding author: Costa, Diana. "Methotrexate-plasmid DNA polyplexes for cancer therapy: Characterization, cancer cell targeting ability and tuned in vitro transfection". Journal of Molecular Liquids 292 (2019): 111391. http://dx.doi.org/10.1016/j.molliq.2019.111391.
    Published • 10.1016/j.molliq.2019.111391
  25. Costa, Diana; Albuquerque, Tânia; Queiroz, João A.; Valente, Artur J.M.. Corresponding author: Costa, Diana. "A co-delivery platform based on plasmid DNA peptide-surfactant complexes: formation, characterization and release behavior". Colloids and Surfaces B: Biointerfaces 178 (2019): 430-438. http://dx.doi.org/10.1016/j.colsurfb.2019.03.029.
    Published • 10.1016/j.colsurfb.2019.03.029
  26. Costa, Diana; Valente, Artur J.M.; Queiroz, João A.; Sousa, Ângela. Corresponding author: Costa, Diana. "Finding the ideal polyethylenimine-plasmid DNA system for co-delivery of payloads in cancer therapy". Colloids and Surfaces B: Biointerfaces 170 (2018): 627-636. http://dx.doi.org/10.1016/j.colsurfb.2018.06.063.
    Published • 10.1016/j.colsurfb.2018.06.063
  27. Costa, Diana; Costa, Carolina; Caldeira, Margarida; Cortes, Luísa; Queiroz, João A.; Cruz, Carla. Corresponding author: Costa, Diana. "Targeting of Cellular Organelles by Fluorescent Plasmid DNA Nanoparticles". Biomacromolecules 18 9 (2017): 2928-2936. http://dx.doi.org/10.1021/acs.biomac.7b00877.
    Published • 10.1021/acs.biomac.7b00877
  28. Coutinho, Eduarda; Batista, Cátia; Sousa, Fani; Queiroz, João; Costa, Diana. Corresponding author: Costa, Diana. "Mitochondrial Gene Therapy: Advances in Mitochondrial Gene Cloning, Plasmid Production, and Nanosystems Targeted to Mitochondria". Molecular Pharmaceutics 14 3 (2017): 626-638. http://dx.doi.org/10.1021/acs.molpharmaceut.6b00823.
    Published • 10.1021/acs.molpharmaceut.6b00823
  29. Salvado, Rúben; Sousa, Fani; Queiroz, João; Costa, Diana. Corresponding author: Costa, Diana. "Development of mitochondrial targeting plasmid DNA nanoparticles: Characterization and in vitro studies". Colloids and Surfaces A: Physicochemical and Engineering Aspects 480 (2015): 287-295. http://dx.doi.org/10.1016/j.colsurfa.2014.12.013.
    Published • 10.1016/j.colsurfa.2014.12.013
  30. Costa, Diana; Valente, Artur J.M.; Queiroz, João. Corresponding author: Costa, Diana. "Stimuli-responsive polyamine-DNA blend nanogels for co-delivery in cancer therapy". Colloids and Surfaces B: Biointerfaces 132 (2015): 194-201. http://dx.doi.org/10.1016/j.colsurfb.2015.04.064.
    Published • 10.1016/j.colsurfb.2015.04.064
  31. Costa, Diana; Valente, Artur J.M.; Queiroz, João. Corresponding author: Costa, Diana. "Plasmid DNA nanogels as photoresponsive materials for multifunctional bio-applications". Journal of Biotechnology 202 (2015): 98-104. http://dx.doi.org/10.1016/j.jbiotec.2014.10.033.
    Published • 10.1016/j.jbiotec.2014.10.033
  32. Costa, Diana; Briscoe, Wuge H.; Queiroz, João. Corresponding author: Costa, Diana. "Polyethylenimine coated plasmid DNA–surfactant complexes as potential gene delivery systems". Colloids and Surfaces B: Biointerfaces 133 (2015): 156-163. http://dx.doi.org/10.1016/j.colsurfb.2015.06.005.
    Published • 10.1016/j.colsurfb.2015.06.005
  33. Santos, João; Sousa, Fani; Queiroz, João; Costa, Diana. Corresponding author: Costa, Diana. "Rhodamine based plasmid DNA nanoparticles for mitochondrial gene therapy". Colloids and Surfaces B: Biointerfaces 121 (2014): 129-140. http://dx.doi.org/10.1016/j.colsurfb.2014.06.003.
    Published • 10.1016/j.colsurfb.2014.06.003
  34. Costa, Diana; Valente, Artur J.M.; Miguel, M. Graça; Queiroz, João. Corresponding author: Costa, Diana. "Plasmid DNA hydrogels for biomedical applications". Advances in Colloid and Interface Science 205 (2014): 257-264. http://dx.doi.org/10.1016/j.cis.2013.08.002.
    Published • 10.1016/j.cis.2013.08.002
  35. Costa, Diana; Valente, Artur J.M.; Miguel, M. Graça; Queiroz, João. Corresponding author: Costa, Diana. "Plasmid DNA microgels for drug/gene co-delivery: A promising approach for cancer therapy". Colloids and Surfaces A: Physicochemical and Engineering Aspects 442 (2014): 181-190. http://dx.doi.org/10.1016/j.colsurfa.2013.02.048.
    Published • 10.1016/j.colsurfa.2013.02.048
  36. Costa, Diana; Valente, Artur J. M.; Miguel, M. Graça; Queiroz, João. Corresponding author: Costa, Diana. "Plasmid DNA Microgels for a Therapeutical Strategy Combining the Delivery of Genes and Anticancer Drugs". Macromolecular Bioscience 12 9 (2012): 1243-1252. http://dx.doi.org/10.1002/mabi.201200096.
    Published • 10.1002/mabi.201200096
  37. Costa, Diana; Queiroz, João; Miguel, M. Graça; Lindman, Björn. Corresponding author: Costa, Diana. "Swelling behavior of a new biocompatible plasmid DNA hydrogel". Colloids and Surfaces B: Biointerfaces 92 (2012): 106-112. http://dx.doi.org/10.1016/j.colsurfb.2011.11.038.
    Published • 10.1016/j.colsurfb.2011.11.038
  38. Burrows, Hugh D.; Costa, Diana; Ramos, M. Luísa; Miguel, M. da Graça; Teixeira, M. Helena; Pais, Alberto A. C. C.; Valente, Artur J. M.; Bastos, Margarida; Bai, Guangyue. "Does cation dehydration drive the binding of metal ions to polyelectrolytes in water? What we can learn from the behaviour of aluminium(iii) and chromium(iii)". Physical Chemistry Chemical Physics 14 22 (2012): 7950. http://dx.doi.org/10.1039/c2cp40480j.
    Published • 10.1039/c2cp40480j
  39. Costa, Diana; Valente, Artur J. M.; Miguel, M. Graça; Queiroz, João. Corresponding author: Costa, Diana. "Gel Network Photodisruption: A New Strategy for the Codelivery of Plasmid DNA and Drugs". Langmuir 27 22 (2011): 13780-13789. http://dx.doi.org/10.1021/la2026285.
    Published • 10.1021/la2026285
  40. Costa, Diana; Valente, Artur J.M.; Miguel, M. Graça; Lindman, Björn. Corresponding author: Costa, Diana. "Light triggered release of solutes from covalent DNA gels". Colloids and Surfaces A: Physicochemical and Engineering Aspects 391 1-3 (2011): 80-87. http://dx.doi.org/10.1016/j.colsurfa.2011.03.046.
    Published • 10.1016/j.colsurfa.2011.03.046
  41. Costa, Diana; Miguel, M. Graça; Lindman, Björn. Corresponding author: Costa, Diana. "Swelling properties of cross-linked DNA gels". Advances in Colloid and Interface Science 158 1-2 (2010): 21-31. http://dx.doi.org/10.1016/j.cis.2009.10.002.
    Published • 10.1016/j.cis.2009.10.002
  42. Costa, Diana; Valente, Artur J.M.; Pais, Alberto A.C.C.; Miguel, M. Graça; Lindman, Björn. Corresponding author: Costa, Diana. "Cross-linked DNA gels: Disruption and release properties". Colloids and Surfaces A: Physicochemical and Engineering Aspects 354 1-3 (2010): 28-33. http://dx.doi.org/10.1016/j.colsurfa.2009.08.009.
    Published • 10.1016/j.colsurfa.2009.08.009
  43. Costa, Diana; Reischl, Martin; Kuzma, Bojan; Brumen, Milan; Zerovnik, Janez; Ribitsch, Volker; Miguel, M. Graça; Lindman, Björn. "Modeling the Surfactant Uptake in Cross-Linked DNA Gels". Journal of Dispersion Science and Technology 30 6 (2009): 954-960. http://dx.doi.org/10.1080/01932690802646413.
    Published • 10.1080/01932690802646413
  44. Costa, Diana; Luísa Ramos, M.; Burrows, Hugh D.; José Tapia, M.; da Graça Miguel, M.. "Using lanthanides as probes for polyelectrolyte–metal ion interactions. Hydration changes on binding of trivalent cations to nucleotides and nucleic acids". Chemical Physics 352 1-3 (2008): 241-248. http://dx.doi.org/10.1016/j.chemphys.2008.06.014.
    Published • 10.1016/j.chemphys.2008.06.014
  45. Costa, Diana; Miguel, M. Graça; Lindman, Björn. Corresponding author: Costa, Diana. "Responsive Polymer Gels:  Double-Stranded versus Single-Stranded DNA". The Journal of Physical Chemistry B 111 37 (2007): 10886-10896. http://dx.doi.org/10.1021/jp0713108.
    Published • 10.1021/jp0713108
  46. Costa, Diana; Miguel, M. Graça; Lindman, Björn. Corresponding author: Costa, Diana. "Effect of Additives on Swelling of Covalent DNA Gels". The Journal of Physical Chemistry B 111 29 (2007): 8444-8452. http://dx.doi.org/10.1021/jp067917q.
    Published • 10.1021/jp067917q
  47. Costa, Diana. "Manipulation of DNA with surfactants and lipids: Compaction and decompaction". ACS (2007):
    Published
  48. Costa, Diana; Hansson, Per; Schneider, Stefanie; Graça Miguel, M.; Lindman, Björn. Corresponding author: Costa, Diana. "Interaction between Covalent DNA Gels and a Cationic Surfactant". Biomacromolecules 7 4 (2006): 1090-1095. http://dx.doi.org/10.1021/bm0508919.
    Published • 10.1021/bm0508919
  49. Costa, D.; Dos Santos, S.; Antunes, F.E.; Miguel, M.G.; Lindman, B.; Costa, Diana. "Some novel aspects of DNA physical and chemical gels". Arkivoc 2006 4 (2006): 161-172. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645659746&partnerID=MN8TOARS.
    Published • 10.3998/ark.5550190.0007.411
  50. Costa, Diana; Burrows, Hugh D.; da Graça Miguel, M.. "Changes in Hydration of Lanthanide Ions on Binding to DNA in Aqueous Solution". Langmuir 21 23 (2005): 10492-10496. http://dx.doi.org/10.1021/la051493u.
    Published • 10.1021/la051493u
Journal issue
  1. Costa, Diana. "Polymeric nanoparticles as drug delivery systems". Frontiers in Biomaterials Science (2022):
    Published • Editor
  2. Costa, Diana. "Biopolymers: Recent Progress and New Perspectives II". Polymers (2022):
    Published
  3. Costa, Diana. "Biopolymers: Recent Progress and New Perspectives". Polymers ISSN 2073-4360 (2021):
    Published • Coeditor
Thesis / Dissertation
  1. Costa, Diana. "Covalent DNA Gels: Synthesis, Swelling and Release Properties". PhD, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2009.
  2. Costa, Diana. "Interaction between DNA and Cations in solution and in gel". Degree, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2003.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/12/13 NanoClock: timing drug delivery in cancer therapy
Department of Life Sciences and Medicine, University of Luxembourg (Luxembourg)
2023/12/11 Mitochondrial gene therapy: from cloning to gene expression
Department of Life Sciences and Medicine, University of Luxembourg (Luxembourg)
2023/11/10 Towards Gene Therapy: Design and Development of targeted delivery systems. Invited Talk at TMElab, University of Zaragoza, Spain
TMElab, University of Zaragoza, Spain (Saragoça, Spain)
2021/12 Cell-penetrating peptides: an invaluable asset for non-viral gene delivery Next-generation delivery systems
(Montpellier, France)
2019/04/11 Fluorescent Plasmid DNA nanoparticles can target different cellular organelles European Biotechnology Congress 2019
(Valencia, Spain)
2018/07/16 Targeting cellular organelles with therapeutical fluorescent nanoparticles International Conference on Biomedical Polymers & Polymeric Biomaterials
(Cracóvia, Poland)
2014/07/23 Cross-linking DNA: from network formation to bio-applications Annual Chemistry Meeting 2014
School of Chemistry, University of Bristol, UK (Bristol, United Kingdom)
2014/05/17 Plasmid DNA microgels for cancer treatment through combination of chemotherapy and gene delivery European Biotechnology Congress
(Lecce, Italy)
2013/12/07 Plasmid DNA based Carriers for improved Cancer Therapy MicroBiotec 13
Sociedade Portuguesa de Biotecnologia (Aveiro, Portugal)
2013/03/14 Plasmid DNA based Systems: a promising approach for Cancer Therapy BioNanoMed 2013, 4th International Congress of Nanotechnology, Medicine & Biology
(Krems, Austria)
2012/06/06 A therapeutical strategy combining the delivery of genes and anticancer drugs EUPOC 2012, Porous Polymer-based Systems: from Design to Application
(Gargnano, Italy)
2011/09/06 Does dehydration drives the binding of trivalent metal ions to polyelectrolytes in aqueous solution? III Jornadas Ibéricas de Fotoquímica
(Granada, Spain)
2011/06/13 A new plasmid DNA hydrogel can find biological applications Workshop on Biopolymers for Medical use
(Montpellier, France)
2010/07/13 Cross-linked DNA Gels: Disruption and Release Properties 43º World Polymer Congress
(Glasgow, United Kingdom)
2008/06/17 Does Cation Dehydration Drive Binding of Trivalent Cations to Polyelectrolytes in Water? Polyelectrolytes 2008
(Coimbra, Portugal)
2007/07/04 Responsive Polymer Gels: Double stranded DNA versus single stranded European Polymer Congress
(Portoroz, Slovenia)
2007/05/16 DNA Gels and Particles COST Meeting
(Coimbra, Portugal)
2007/04/18 Swelling of DNA Gels as a function of DNA conformation PolyChar 15 “World Forum on Advanced Materials
(Búzios, Brazil)
2006/07/20 Responsive cross-linked DNA Gels 41º World Polymer Congress
(Rio de Janeiro, Brazil)
2006/03/20 Swelling of chemically cross-linked DNA Gels 3rd CIPSNAC Workshop, “Colloidal and Interfacial Properties of Synthetic Nucleic Acid Complexes-Assembly of nanostructured DNA particles and surfaces
(Dublin, Ireland)
2006/03/13 Swelling of covalent DNA Gels: the effect of additives 2nd NEONUCLEI Workshop
(Penacova, Portugal)
2005/12/17 Dehydration of Lanthanide ions on Binding to DNA: Effects of Nucleotide Conformation 8º Encontro Nacional de Fotoquímica (8FOT)
(Coimbra, Portugal)
2005/05/05 Binding of Lanthanide Ions to DNA. Hydration effects CIPSNAC Workshop, “Colloidal and Interfacial Properties of Synthetic Nucleic Acid Complexes-Assembly of nanostructured DNA particles and surfaces
(Penacova, Portugal)
2004/07/26 Covalent DNA Gels- A new way to study DNA-cosolute interactions 1st CIPSNAC Workshop, “Colloidal and Interfacial Properties of Synthetic Nucleic Acid Complexes-Assembly of nanostructured DNA particles and surfaces
(Munique, Germany)
2004/06/17 Skin Formation in Covalent DNA gels Workshop on Membranes and Delivery Systems
(Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/06/19 - Current Desenvolvimento de nanopartículas de co-libertação de temozolomida e DNA plasmídico para tratamento de glioblastoma
Supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2019/09/01 - Current Cancer Chronotherapy: A role for the circadian clock in the therapeutic effect mediated by Drug/Gene co-delivery
Supervisor
Universidade da Beira Interior, Portugal
2019/09/01 - Current Biosynthesis, isolation and targeted delivery of a minicircle DNA vaccine against HPV -associated cervical cancer
Co-supervisor
Universidade da Beira Interior, Portugal
2023/09/01 - 2027/08/30 TDD4CC: Targeted Drug Delivery for Cervical Cancer Therapy
Co-supervisor
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2020/12/31 - 2024/12/31 The bridge between Nanotechnology and Chronobiology: Circadian control of Cancer Therapy by Raman nanosensors
Supervisor
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2020/12/01 - 2024/12/31 Mannosylated minicircle DNA nanovaccine against COVID-19
Co-supervisor
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2023/07/01 - 2024/11/19 Terapia génica do Glioblastoma por administração nasal: desenvolvimento de um nano-sistema peptídico
Supervisor
 Ciências Farmacêuticas (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2021/12/06 - 2023/11/23 Desenvolvimento de vetores baseados em péptidos para direcionamento à mitocôndria
Supervisor
 Biotecnologia (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2022/07/01 - 2023/10/30 Formulation and characterization of taxifolin delivery systems as an anti-Human Papillomavirus drug
Co-supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2023/03/13 - 2023/04/28 A relação entre a cronobiologia e a nanotecnologia: estudar a influência do ritmo circadiano na performance de um sistema de entrega
Supervisor
 Ciências Biomédicas (Degree)
Universidade da Beira Interior, Portugal
2023/03/13 - 2023/04/28 A relação entre a cronobiologia e a nanotecnologia: estudar a influência do ritmo circadiano na performance de um sistema de entrega
Supervisor
 Ciências Biomédicas (Degree)
Universidade da Beira Interior, Portugal
2021/07/01 - 2022/11/22 Delivery of anti-HPV drugs to cervical cancer cells
Co-supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2021/07/01 - 2022/11/22 Desenvolvimento de uma vacina de DNA minicircular contra a COVID-19
Co-supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2020/09/01 - 2022/03/04 Desenvolvimento de uma nanovacina de DNA minicircular funcionalizada com potencial ação imunoterapêutica
Co-supervisor
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2021/04/01 - 2021/06/30 Drug transport across the brain barriers: advances in the use of Nano-Biomaterials for Alzheimer´s disease
Supervisor
 Biotecnologia (Degree)
Universidade da Beira Interior, Portugal
2021/05/03 - 2021/06/07 Explorar a relação entre a cronobiologia e a nanotecnologia: o papel do ritmo circadiano na performance de um sistema de entrega de genes
Supervisor
 Ciências Biomédicas (Degree)
Universidade da Beira Interior, Portugal
2021/05/03 - 2021/06/07 Explorar a relação entre a cronobiologia e a nanotecnologia: o papel do ritmo circadiano na performance de um sistema de entrega de genes
Supervisor
 Ciências Biomédicas (Degree)
Universidade da Beira Interior, Portugal
2021/05/03 - 2021/06/07 Terapia génica mitocondrial: Desenvolvimento de vetores baseados em péptidos
Supervisor
 Ciências Biomédicas (Degree)
Universidade da Beira Interior, Portugal
2019/09/01 - 2020/11/30 Gene Therapy for Glioblastoma: Nanobiotechnology-based strategies for targeted delivery
Supervisor
Universidade da Beira Interior, Portugal
2019/09/01 - 2020/11/24 Entrega direccionada às células dendríticas: Funcionalização de um vetor de DNA plasmídico com ligandos.
Co-supervisor
 Biotecnologia (Master)
Universidade da Beira Interior, Portugal
2019/09/01 - 2020/11/06 Desenho e desenvolvimento de sistemas inovadores de transporte de DNA plasmídico.
Supervisor
 Bioengenharia (Master)
Universidade da Beira Interior, Portugal
2019/09/01 - 2020/10 Mitochondrial Gene Therapy: Development of a mitochondrial targeted peptide/plasmid DNA vector
Supervisor
Universidade da Beira Interior, Portugal
2018/04/01 - 2019/08/30 Gene Therapy for Mitochondrial DNA disease: Development of a mitochondrial-targeted vector.
Supervisor
Universidade da Beira Interior, Portugal
2019/02/01 - 2019/07/31 New drug delivery systems for clinical applications
Co-supervisor
Complejo Asistencial Universitario de Salamanca, Spain
2018/09/01 - 2019/07/31 Novos sistemas de transporte de DNA plasmídico: Desenho, desenvolvimento e avaliação in vitro
Supervisor
 Biotecnologia (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2017/07/01 - 2018/10/31 Terapia do cancro do colo do útero: Avaliação do efeito terapêutico da acção combinada de uma droga e do DNA plasmídico
Supervisor
 Biotecnologia (Master)
Universidade da Beira Interior, Portugal
2017/08/01 - 2018/10/30 Terapia Génica Mitocondrial: Estudos in vitro usando um sistema de transporte de DNA palsmídico (pDNA) com afinidade pela mitocôndria.
Supervisor
 Ciências Biomédicas 2º ciclo (Master)
Universidade da Beira Interior, Portugal
2018/02/01 - 2018/07/31 Optimization of gene delivery vectors for cancer therapy
Co-supervisor
Complejo Asistencial Universitario de Salamanca, Spain
2018/02/01 - 2018/06/30 Desenvolvimento de vetores baseados em rodamina para aplicação em Terapia Génica Mitocondrial
Supervisor
Universidade da Beira Interior, Portugal
2018/02/01 - 2018/06/30 Sistemas com afinidade mitocondrial: Avaliação in vitro.
Supervisor
Universidade da Beira Interior, Portugal
2016/07/01 - 2017/10/30 Terapia do cancro do colo do útero
Co-supervisor
 Biotecnologia (Master)
Universidade da Beira Interior, Portugal
2015/07/01 - 2016/10/31 Obtenção de uma vacina de DNA para prevenção do cancro do colo do útero
Co-supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2014/07/01 - 2015/10/31 Mitochondrial gene therapy in Parkinson´s disease: Cloning mitochondrial gene ND1
Supervisor
 Biotecnologia (Master)
Universidade da Beira Interior, Portugal
2014/07/01 - 2015/10/30 Terapia génica mitocondrial: Desenvolvimento de um vetor com afinidade pela mitocôndria
Supervisor
 Biotecnologia (Master)
Universidade da Beira Interior, Portugal
2015/02/01 - 2015/06/30 Terapia Génica Mitocondrial: Desenvolvimento de nano-sistemas direcionados à mitocôndria
Supervisor
 Biotecnologia (Degree)
Universidade da Beira Interior, Portugal
2013/09/01 - 2014/10/30 Transfection efficiency of a vector for mitochondrial gene therapy
Supervisor
 Bioquímica 2º ciclo (Master)
Universidade da Beira Interior, Portugal
2012/07/01 - 2013/10/30 Gene Therapy-Development of a new nanocarrier system for mitochondrial gene therapy
Supervisor
 Ciências biomédicas 2º ciclo (Master)
Universidade da Beira Interior, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2014/10/01 - 2014/12/10 Workshop "A Química da Biologia" (2014/12/09 - 2014/12/10)
Workshop (Co-organisor)
 Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/11/24 Plasmid DNA-loaded calcium phosphate functional nanocomplexes: innovative approach against cervical cancer
(Thesis) Main arguer
 Matilde Bogalheiro Costa (Master)
Universidade da Beira Interior, Portugal
2022/06/14 Nanopartículas de prata: Estruturas aplicadas ao diagnóstico e tratamento do cancro
(Thesis) Arguer
 Lara Beatriz Ramalhete dos Reis Serra (Other)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2021/07/28 Development of cationic polymeric nanoparticles for plasmid DNA vaccine delivery
(Thesis) Main arguer
 Renato Pereira Nunes (Master)
Universidade da Beira Interior, Portugal
2021/06/29 The potential of nasal polymeric nano-formulations
(Thesis) Main arguer
 Maria Mireia Solano (Master)
Universidad de Salamanca, Spain
2021/06/22 Sistema multifuncional para a entrega de uma vacina de DNA contra a COVID-19
(Thesis) Arguer
 Beatriz da Silva Carvalho (Other)
Universidade da Beira Interior, Portugal
2020/07/07 Biosynthesis and purification of DNA vectors as therapeutic approaches against Human Papillomavirus infection
(Thesis) Arguer
 Ana Margarida Cardoso Valério de Almeida (PhD)
Universidade da Beira Interior, Portugal
2020/01/08 Gellan microspheres application for capture or purification of plasmid DNA vaccine
(Thesis) Main arguer
 Diana Vanessa Duarte Gomes (Master)
Universidade da Beira Interior Faculdade de Ciências, Portugal
2019/06 Nanopartículas de ouro guiadas por aptameros de G-quadruplex para entrega de fármacos em células tumorais do colo do útero
(Thesis) Arguer
 André Miguel Mateus Rico (Other)
Universidade da Beira Interior Faculdade de Ciências, Portugal
2019/05 Funcionalização do polímero natural de gelana para captura de DNA plasmídico
(Thesis) Main arguer
 Joana Catarina Leitão Canilho (Other)
Universidade da Beira Interior Faculdade de Ciências, Portugal
2018/05 Sistemas baseados em quitosano modificado para a entrega de DNA minicircular às células cancerígenas do colo do útero
(Thesis) Main arguer
 Ana Sofia Mota Martins Serra (Other)
Universidade da Beira Interior Faculdade de Ciências, Portugal
2016/06 Sistemas de entrega direcionada da vacina de DNA plasmídico HPV-16 E6/E7 às células apresentadoras de antigénios
(Thesis) Main arguer
 Rúben Miguel Ribeiro Faria (Other)
Universidade da Beira Interior Faculdade de Ciências, Portugal
2016/05 Desenvolvimento de nano-transportadores para entrega direcionada do DNA plasmídico às células tumorais do colo do útero
(Thesis) Main arguer
 Ana Raquel Santos Nunes (Other)
Universidade da Beira Interior Faculdade de Ciências, Portugal
2016/05 Uso de sistemas de entrega de fármacos com siRNA na terapia anti tumoral
(Thesis) Main arguer
 Ana Rita Lima de Sousa (Other)
Universidade da Beira Interior Faculdade de Ciências, Portugal
2015/06 Ensaios de Biocompatibilidade de materiais para futuras aplicações em Engenharia de Tecidos
(Thesis) Main arguer
 Vasco André Brandão Pinho (Other)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2014/10 Estudo de novos ligandos para purificação de ácidos nucleicos
(Thesis) Main arguer
 Cyrille Feijó (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2014/10 Development of new biomaterials to be applied as skin substitutes
(Thesis) Arguer
 Maximiano José Prata Ribeiro (PhD)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2014/07 Hidrogel de quitosano fotoresponsivo no processo de cicatrização e no combate a infeções microbianas
(Thesis) Main arguer
 Jorge Daniel Barroca Ferreira (Other)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2014/07 Uso de Hidrogéis na cicatrização de feridas
(Thesis) Main arguer
 Ana Rita Rodrigues Soares (Other)
Universidade da Beira Interior Faculdade de Ciências, Portugal
2012/06 Osteoporose: uma doença do osso
(Thesis) Main arguer
 Màrcia Cristina Afonso Barros (Other)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2012/06 Epidermólise bolhosa: do diagnóstico ao tratamento
(Thesis) Main arguer
 Helena Pissara (Other)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal

Committee member

Activity description
Role 		Institution / Organization
2022/11 - Current Comissão de Formação & Ensino, CICS-UBI
Coordinator
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2011/01/01 - 2020/12/30 Comissão de Formação de Jovens Investigadores
Member
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015/01/01 - 2017/12/30 Comissão de Comunicação & Imagem
Member
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2011/01/01 - 2013/12/30 Comissão do Centro de Microscopia Electrónica
Member
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2010/01/01 - 2010/12/30 Comissão de Formação de Jovens Investigadores
Coordinator
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Conference scientific committee

Conference name Conference host
2018/06/01 - 2019/03/30 European Biotechnology Congress 2019 Valencia, Espanha

Consulting

Activity description Institution / Organization
2015/04/01 - 2015/06/30 Consultora. Elan Pharmaceuticals Company, Dublin, Ireland., Ireland

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/11/03 - 2023/11/03 Workshop on Gene therapy: Advances in the last decade Workshop (Postgraduate Certificate) Universidad de Salamanca, Spain
2023/07/10 - 2023/07/10 Biotecnologia Farmacêutica Biotecnologia (Postgraduate Certificate) Universidad de Salamanca, Spain
2023/05/02 - 2023/05/12 Biomaterials Ciências Biomédicas (Licenciatura) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2023/05/02 - 2023/05/12 Biomaterials Bioquimica (Licenciatura) Universidade da Beira Interior Faculdade de Ciências, Portugal
2023/05/02 - 2023/05/12 Biomaterials Biotecnologia (Licenciatura) Universidade da Beira Interior Faculdade de Ciências, Portugal
2022/12/12 - 2022/12/13 Surface-coated nanomaterials (Master) Universität Basel Universitätsbibliothek Medizin, Switzerland
2022/05/02 - 2022/05/27 Biomaterials Biotecnologia (Licenciatura) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2022/05/02 - 2022/05/27 Biomaterials Bioquímica (Licenciatura) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2022/05/02 - 2022/05/27 Biomaterials Ciências Biomédicas (Licenciatura) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2022/05/02 - 2022/05/27 Biomaterials Bioengenharia (Licenciatura) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2021/10 - 2021/11 Controlled Delivery Systems (Graduado) Aix-Marseille Université, France
2020/06/01 - 2020/06/12 Biochemistry/bio-nanotechnology Biotechnology (Masterexamen) Metropolitan State University of Denver School of Letters Arts and Sciences, United States
2018/11 - 2018/11 Pharmaceutic Biotechnology Ciências Farmacêuticas e Biotecnologia (Mestrado integrado) Universidade da Beira Interior, Portugal
2016 - 2016 Biotechnology Bioengenharia (Mestrado integrado) Universidade da Beira Interior, Portugal
2015/01/01 - 2015/01/30 Colloidal Materials Chemistry (Licence) School of Chemistry, University of Bristol, UK, United Kingdom
2011/10/01 - 2011/12/20 Biologia Celular Medicina (Mestrado integrado) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2010/10/01 - 2010/12/18 Biologia Celular Medicina (Mestrado integrado) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2019/07 - 2019/07 Comissão de avaliação de comunicações orais apresentadas em simpósio. Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2018/07 - 2018/07 Comissão de avaliação de comunicações orais apresentadas em simpósio.
Evaluator
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017/07 - 2017/07 Comissão de avaliação de comunicações orais apresentadas em simpósio.
Evaluator
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2016/07 - 2016/07 Comissão de avaliação de comunicações orais apresentadas em simpósio.
Evaluator
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015/07 - 2015/07 Comissão de avaliação de comunicações orais apresentadas em simpósio
Evaluator
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2014/07 - 2014/07 Comissão de avaliação de comunicações orais em simpósio
Evaluator
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2020/08/22 A PhD student, under the guidance of Diana Costa, is going to develop a vaccine against COVID-19. Jornal "O Interior"
2020/08/17 PhD student in Biomedicine at the University of Beira Interior, supervised by Diana Costa, received a research grant (FCT) for the development of a preventive and therapeutic DNA vaccine against COVID-19. Viva Serra Digital Magazine
2020/08/12 A PhD Student at the University of Beira Interior, under the supervision of Diana Costa,won a doctoral scholarship from FCT to create a DNA vaccine towards Covid-19. Diario de Notícias
2020/08/10 PhD Student at the University of Beira Interior, under the supervision of Diana Costa, will develop a nanovaccine against Covid-19. País ao Minuto
2020/08/10 PhD Student at the University of Beira Interior, under the supervision of Diana Costa, intends to develop a DNA based vaccine towards Covid-19. Jornal do Fundão
2020/08/10 A PhD Student at the University of Beira Interior, supervised by Diana Costa, will conceive a nanovaccine for Covid-19. beira.pt

Interview (tv / radio show)

Program Topic
2020/12/05 - Current Flagrant Direct - Radio Cova da Beira UBI researchers are working on an innovative vaccine against Covid-19
2020/11/21 - Current TV Show "Página 2" Project "Development of a minicircular DNA vaccine against COVID-19" was awarded a FCT PhD scholarship to student Dalinda Eusébio
2020/11/20 - Current Jornal das 8: "IMMUNITY - Great Report TVI" Innovative project "Development of a minicircular DNA vaccine against COVID-19" was awarded a FCT PhD scholarship to student Dalinda Eusébio and is being developed at CICS-UBI,Covilhã, coordinated by ASousa and Diana Costa researchers.
2020/09/03 - Current TVI 24 A NANOVACCINE, DRUG AND TEST WITH RESULTS IN 45 MINUTES: THE FIGHT OF THE PORTUGUESE SCIENTIFIC COMMUNITY AGAINST COVID
2020/09/02 - Current TV show "É ou NÃO É? - The Great Debate - RTP1 In Search of Immunity - Debate on the status of vaccination in Portugal.
2020/09/02 - Current TV Show "SIC Notícias" University of Beira Interior is developing a vaccine against Covid-19

Journal scientific committee

Journal title (ISSN) Publisher
2020/03/01 - Current Materials Today Bio Elsevier
2020/01/01 - Current Polymers (2073-4360) MDPI
2020/01/01 - Current Pharmaceutics MDPI
2019/02/01 - Current Medicinal Research Reviews (1098-1128) Wiley (John Wiley & Sons)
2019/01/01 - Current Cancers MDPI
2018/05/01 - Current RSC Advances (2046-2069) The Royal Society of Chemistry
2017/03/01 - Current Journal of Molecular Liquids (0167-7322) Elsevier
2017/01/01 - Current Molecular Pharmaceutics ACS
2015/01/01 - Current Biomaterials (0142-9612) Elsevier
2015/01/01 - Current Journal of Materials Chemistry C Royal Society of Chemistry
2014/01/01 - Current Biomacromolecules ACS
2014/01/01 - Current Colloids and Surfaces B Biointerfaces (0927-7765) Elsevier
2013/01/01 - Current Colloids and Surfaces A Physicochemical and Engineering Aspects (0927-7757) Elsevier
2012/01/01 - Current Acta Biomaterialia (1742-7061) Elsevier

Other jury / evaluation

Activity description Institution / Organization
2021/10 - Current Review Editor of "Frontiers in Biomaterials Science" Journal.
2023/09/12 - 2023/09/28 Jury in two Research Grant Applications. Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Distinctions

Award

2023 INTERNATIONAL BEST RESEARCHER AWARD - for the research "Design of experiments to select triphenylphosphonium-polyplexes with suitable physicochemical properties for mitochondrial gene therapy"
World Research Council and ISSN Awards , India
2015 The best ideas from young researchers
University of Macau, Macau SAR China
2010 Best Oral Presentation EPF
2007 Bruce Hartmannn Prize For a Young Scientist Presentation
2007 Short-term Scientific COST Grant
2006 Travel Grant

Other distinction

2023 Erasmus+ Mobility Grant
Universidade da Beira Interior, Portugal
2023 Distinction in Mitochondrial Gene Therapy
World Mitochondria Society, United States
2003 Bolsa de Mérito-Erasmus
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal