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In 2014 I completed my PhD degree in Genetics at São Paulo State University (UNESP). My work focused on the understanding of genetic determinants of the malaria immune response. I then became interested in antimalarial drug discovery, and in 2016 I obtained a FAPESP fellowship and I joined to Tropical Diseases lab at the University of Campinas (UNICAMP). There, I developed chemoinformatic strategies which I used to identify new promising compounds against malaria. This was followed by 2-years post-doctoral at the Instituto de Higiene e Medicina Tropical/Universidade Nova de Lisboa (IHMT/NOVA). I am currently a Júnior Researcher (Chemoinformatics) at Global Health and Tropical Medicine Center of IHMT/NOVA. I have so far published 29 articles, 2 book chapters and I have co-supervie(d) 2 BSc, 1 MSc, and 2 PhD students. Presently, the most relevant part of my work is focused on Computer-Assisted Drug Design, aiming at discovering new drug candidates for Neglected and Tropical diseases.
Identification

Personal identification

Full name
Gustavo Capatti Cassiano

Citation names

  • Cassiano, Gustavo
  • CASSIANO, GC

Author identifiers

Ciência ID
FB1F-A7D3-DEC9
ORCID iD
0000-0002-6971-5974
Researcher Id
G-5728-2013

Addresses

  • Rua da Junqueira 100, 1349-008, Lisbon, Lisbon, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Health Sciences - Tropical Medicine
  • Medical and Health Sciences - Health Sciences - Infectious Diseases
Education
Degree Classification
2021/02 - 2022/12
Concluded
Identification of new antimalarial treatments through a target-centred "drug repositioning" approach (Pós-doutoramento)
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016/02 - 2020/12
Concluded
Identifying protein kinase inhibitors as antimalarial agents using chemogenomic, bioinfomatics and phenotypic strategies: focus in Plasmodium vivax. (Pós-doutoramento)
Universidade Estadual de Campinas, Brazil
2010/03/01 - 2014/02/27
Concluded
Genetics (Doctor)
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de São José do Rio Preto Instituto de Biociências Letras e Ciências Exatas, Brazil
2008/02/10 - 2010/02/26
Concluded
Genetics (Master)
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de São José do Rio Preto Instituto de Biociências Letras e Ciências Exatas, Brazil
2004/02/10 - 2008/01/10
Concluded
Biology (Licence)
Universidade Estadual Paulista Júlio de Mesquita Filho Câmpus de São José do Rio Preto Instituto de Biociências Letras e Ciências Exatas, Brazil
Affiliation

Science

Category
Host institution
Employer
2022/01/01 - Current Researcher (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2020/02/01 - 2022/01/01 Postdoc (Research) Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2016/02/01 - 2019/12/31 Postdoc (Research) Universidade Estadual de Campinas, Brazil
Projects

Grant

Designation Funders
2023/05/01 - Current Future antimalarials: towards multi-stage compounds for treatment and transmission-blocking
UID/04413/2020
Principal investigator
Ongoing
2018 - Current Development of new tools for search and validation of molecular targets for therapy against Plasmodium vivax
2017/18611-7
Researcher
Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil
Ongoing
2018 - Current Identification of new antimalarial treatments through a target-centred "drug repositioning" approach
PTDC/SAU-PAR/28459/2017
Researcher
Fundação para a Ciência e a Tecnologia, Portugal
Ongoing
2017/10/30 - 2019/12/31 Identifying protein kinase inhibitors as antimalarial agents using chemogenomic, bioinfomatics and phenotypic strategies: focus in Plasmodium vivax
3129/17
Principal investigator
Universidade Estadual de Campinas Fundo de Apoio ao Ensino à Pesquisa e à Extensão
Concluded

Contract

Designation Funders
2020/01/01 - 2024/12/31 Global Health and Tropical Medicine
Researcher
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020 - 2021 Identification of new antimalarial treatments through a target-centred “drug repositioning” approach
PTDC/SAU-PAR/28459/2017
Post-doc Fellow
Fundação para a Ciência e a Tecnologia, Portugal
Concluded
2016/02/01 - 2020/01/01 Identifying protein kinase inhibitors as antimalarial agents using chemogenomic, bioinfomatics and phenotypic strategies: focus in Plasmodium vivax
2015/20774-6
Post-doc Fellow
Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil
Concluded
Outputs

Publications

Book chapter
  1. Storti-Melo, L. M.; CASSIANO, GC; Baptista A.R.S; Machado RLD. "Circumsporozoite protein from Plasmodium vivax and its relationship to human malaria". In New Advances in Neglected Tropical Diseases. 2023.
  2. Cassiano, G.C.; Tavella, T.A.; Nascimento, M.N.; Rodrigues, D.A.; Cravo, P.V.L.; Andrade, Carolina Horta; Costa, Fabio Trindade Maranhão. "Targeting malaria protein kinases". In Advances in Protein Chemistry and Structural Biology, 225-274. Elsevier, 2021.
    10.1016/bs.apcsb.2020.10.004
  3. Tavella, T.A.; Cassiano, G.C.; Costa, Fabio Trindade Maranhão; Sunnerhagen, P.; Bilsland, E.. "Yeast-based high-throughput screens for discovery of kinase inhibitors for neglected diseases". In Advances in Protein Chemistry and Structural Biology, 275-309. Elsevier, 2021.
    10.1016/bs.apcsb.2020.09.007
Journal article
  1. Cassiano, Gustavo Capatti; Martinelli, Axel; Mottin, Melina; Neves, Bruno Junior; Andrade, Carolina Horta; Ferreira, Pedro Eduardo; Cravo, Pedro. "Whole genome sequencing identifies novel mutations in malaria parasites resistant to artesunate (ATN) and to ATN + mefloquine combination". Frontiers in Cellular and Infection Microbiology 14 (2024): http://dx.doi.org/10.3389/fcimb.2024.1353057.
    10.3389/fcimb.2024.1353057
  2. Gonçalves, Adriana F.; Lima-Pinheiro, Ana; Teixeira, Miguel; Cassiano, Gustavo Capatti; Cravo, Pedro; Ferreira, Pedro E.. "Mutation in the 26S proteasome regulatory subunit rpn2 gene in Plasmodium falciparum confers resistance to artemisinin". Frontiers in Cellular and Infection Microbiology 14 (2024): http://dx.doi.org/10.3389/fcimb.2024.1342856.
    10.3389/fcimb.2024.1342856
  3. Tomaz, Kaira C. P.; Tavella, Tatyana A.; Borba, Joyce V. B.; Salazar-Alvarez, Luis C.; Levandoski, João E.; Mottin, Melina; Sousa, Bruna K. P.; et al. "Identification of potential inhibitors of casein kinase 2 alpha of Plasmodium falciparum with potent in vitro activity". Antimicrobial Agents and Chemotherapy (2023): http://dx.doi.org/10.1128/aac.00589-23.
    10.1128/aac.00589-23
  4. Ramírez, Aina D.R.; de Jesus, Myrela C.S.; Menezes, Rubens A.O.; Santos-Filho, Marcelo C.; Gomes, Margarete S.M.; Pimenta, Tamirys S.; Barbosa, Vanessa S.; et al. "Polymorphisms in Toll-Like receptors genes and their associations with immunological parameters in Plasmodium vivax malaria in the Brazil-French Guiana Border". Cytokine 169 (2023): 156278. http://dx.doi.org/10.1016/j.cyto.2023.156278.
    10.1016/j.cyto.2023.156278
  5. Anyse P. Essoh; Gustavo Capatti Cassiano; Filipa Mandim; Lillian Barros; Isildo Gomes; Medeiros, MM; Mónica Moura; Pedro Vitor Lemos Cravo; Maria M. Romeiras. "Antimalarial and Cytotoxic Activity of Native Plants Used in Cabo Verde Traditional Medicine". Plants 12 4 (2023): 963-963. http://dx.doi.org/10.3390/plants12040963.
    10.3390/plants12040963
  6. "CYP2D6 Allele Frequency in Five Malaria Vivax Endemic Areas From Brazilian Amazon Region". Frontiers in Pharmacology 12 (2021): http://dx.doi.org/10.3389/fphar.2021.542342.
    10.3389/fphar.2021.542342
  7. Cassiano, Gustavo. "Violacein-Induced Chaperone System Collapse Underlies Multistage Antiplasmodial Activity.". ACS infectious diseases (2021): https://doi.org/10.1021/acsinfecdis.0c00454.
    10.1021/acsinfecdis.0c00454
  8. Lima, Marilia N. Nascimento; Borba, Joyce V. B.; Cassiano, Gustavo C.; Mottin, Melina; Mendonça, Sabrina Silva; Silva, Arthur C.; Tomaz, Kaira C. P.; et al. "Artificial intelligence applied for the rapid identification of new antimalarial candidates with dual-stage activity". ChemMedChem (2020): http://dx.doi.org/10.1002/cmdc.202000685.
    10.1002/cmdc.202000685
  9. Capobianco, Marcela Petrolini; Cassiano, Gustavo Capatti; Storti-Melo, Luciane Moreno; Pimenta, Tamirys Simão; Rodrigues, Ana Paula Drummond; Arruda, José Eduardo Gomes; Pinto, Marcia Ribeiro; et al. "Polymorphism in the IL-1ß promoter is associated with IgG antibody response to circumsporozoite protein repeats of Plasmodium vivax". Transactions of The Royal Society of Tropical Medicine and Hygiene 114 11 (2020): 858-865. http://dx.doi.org/10.1093/trstmh/traa055.
    10.1093/trstmh/traa055
  10. Ferreira, Letícia Tiburcio; Rodrigues, Juliana; Cassiano, Gustavo Capatti; Tavella, Tatyana Almeida; Tomaz, Kaira Cristina Peralis; Baia-da-Silva, Djane Clarys; Souza, Macejane Ferreira; et al. "Computational Chemogenomics Drug Repositioning Strategy Enables the Discovery of Epirubicin as a New Repurposed Hit for Plasmodium falciparum and P. vivax". Antimicrobial Agents and Chemotherapy 64 9 (2020): http://dx.doi.org/10.1128/aac.02041-19.
    Published • 10.1128/aac.02041-19
  11. Cassiano, Gustavo. "Deep Learning-driven research for drug discovery: Tackling Malaria". PLOS Computational Biology (2020): http://dx.doi.org/10.1371/journal.pcbi.1007025.
    10.1371/journal.pcbi.1007025
  12. Cassiano, Gustavo. "Integrative Multi-Kinase Approach for the Identification of Potent Antiplasmodial Hits". Frontiers in Chemistry (2019): http://dx.doi.org/10.3389/fchem.2019.00773.
    10.3389/fchem.2019.00773
  13. Cassiano, Gustavo. "Chalcones as a basis for computer-aided drug design: innovative approaches to tackle malaria". Future Medicinal Chemistry (2019): http://dx.doi.org/10.4155/fmc-2018-0255.
    10.4155/fmc-2018-0255
  14. Pippione, Agnese C.; Sainas, Stefano; Goyal, Parveen; Fritzson, Ingela; Cassiano, Gustavo C.; Giraudo, Alessandro; Giorgis, Marta; et al. "Hydroxyazole scaffold-based Plasmodium falciparum dihydroorotate dehydrogenase inhibitors: Synthesis, biological evaluation and X-ray structural studies". European Journal of Medicinal Chemistry 163 (2019): 266-280. http://dx.doi.org/10.1016/j.ejmech.2018.11.044.
    10.1016/j.ejmech.2018.11.044
  15. Cassiano, Gustavo. "A new heparan sulfate from the mollusk Nodipecten nodosus inhibits merozoite invasion and disrupts rosetting and cytoadherence of Plasmodium falciparum". Memórias do Instituto Oswaldo Cruz (2019): http://dx.doi.org/10.1590/0074-02760190088.
    10.1590/0074-02760190088
  16. Cassiano, Gustavo. "Chloroquine and mefloquine resistance profiles are not related to the circumsporozoite protein (CSP) VK210 subtypes in field isolates of Plasmodium vivax from Manaus, Brazilian Amazon". Memórias do Instituto Oswaldo Cruz (2019): http://dx.doi.org/10.1590/0074-02760190054.
    10.1590/0074-02760190054
  17. Cassiano, Gustavo. "Genetic sequence characterization and naturally acquired immune response to Plasmodium vivax Rhoptry Neck Protein 2 (PvRON2)". Malaria Journal (2018): http://dx.doi.org/10.1186/s12936-018-2543-7.
    10.1186/s12936-018-2543-7
  18. Lima, Marilia N. N.; Melo-Filho, Cleber C.; Cassiano, Gustavo C.; Neves, Bruno J.; Alves, Vinicius M.; Braga, Rodolpho C.; Cravo, Pedro V. L.; et al. "QSAR-Driven Design and Discovery of Novel Compounds With Antiplasmodial and Transmission Blocking Activities". Frontiers in Pharmacology 9 (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000426694400001&KeyUID=WOS:000426694400001.
    10.3389/fphar.2018.00146
  19. Chaves, Lana Bitencourt; Perce-da-Silva, Daiana de Souza; Rodrigues-da-Silva, Rodrigo Nunes; Martins da Silva, Joao Herminio; Cassiano, Gustavo Capatti; Dantas Machado, Ricardo Luiz; Pratt-Riccio, Lilian Rose; Banic, Dalma Maria; Lima-Junior, Josue da Costa. "Plasmodium vivax Cell Traversal Protein for Ookinetes and Sporozoites (PvCelTOS) gene sequence and potential epitopes are highly conserved among isolates from different regions of Brazilian Amazon". Plos Neglected Tropical Diseases 11 2 (2017): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000395741700025&KeyUID=WOS:000395741700025.
    10.1371/journal.pntd.0005344
  20. Furini, Adriana A. C.; Capobianco, Marcela P.; Storti-Melo, Luciane M.; Cunha, Maristela G.; Cassiano, Gustavo C.; Machado, Ricardo Luiz D.. "Cytokine gene polymorphisms are not associated with anti-PvDBP, anti-PvAMA-1 or anti-PvMSP-1(19) IgG antibody levels in a malaria-endemic area of the Brazilian Amazon". Malaria Journal 15 (2016): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000379813700006&KeyUID=WOS:000379813700006.
    10.1186/s12936-016-1414-3
  21. Adriana Antônia da Cruz Furini; Gustavo Capatti Cassiano; Marcela Petrolini Capobianco; Sidney Emanuel Batista dos Santos; Ricardo Luiz Dantas Machado. "Frequency of TNFA, INFG, and IL10 Gene Polymorphisms and Their Association with Malaria Vivax and Genomic Ancestry". Mediators of Inflammation 2016 (2016): 1-12. https://doi.org/10.1155%2F2016%2F5168363.
    10.1155/2016/5168363
  22. GOMES, Margarete do Socorro Mendonça; VIEIRA, José Luiz Fernandes; CASSIANO, Gustavo Capatti; MUSSET, Lise; LEGRAND, Eric; NACHER, Mathieu; COUTO, Vanja Suely Calvosa D'Almeida; MACHADO, Ricardo Luiz Dantas; COUTO, Álvaro Augusto Ribeiro D'Almeida. "EVALUATION OF CIRCUMSPOROZOITE PROTEIN OF Plasmodium vivax TO ESTIMATE ITS PREVALENCE IN OIAPOQUE , AMAPÁ STATE, BRAZIL, BORDERING FRENCH GUIANA". Revista do Instituto de Medicina Tropical de São Paulo 58 0 (2016): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=SCIELO&KeyUT=SCIELO:S0036-46652016005000504&KeyUID=SCIELO:S0036-46652016005000504.
    10.1590/S1678-9946201658072
  23. Cassiano, Gustavo C.; Furini, Adriana A. C.; Capobianco, Marcela P.; Storti-Melo, Luciane M.; Cunha, Maristela G.; Kano, Flora S.; Carvalho, Luzia H.; et al. "Polymorphisms in B Cell Co-Stimulatory Genes Are Associated with IgG Antibody Responses against Blood-Stage Proteins of Plasmodium vivax". Plos One 11 2 (2016): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000371276100103&KeyUID=WOS:000371276100103.
    10.1371/journal.pone.0149581
  24. Ribeiro, Bruno de Paulo; Cassiano, Gustavo Capatti; de Souza, Rodrigo Medeiros; Cysne, Dalila Nunes; Grigolin Grisotto, Marcos Augusto; Silva de Azevedo dos Santos, Ana Paula; Farias Marinho, Claudio Romero; Dantas Machado, Ricardo Luiz; Fernandes Nascimento, Flavia Raquel. "Polymorphisms in Plasmodium vivax Circumsporozoite Protein (CSP) Influence Parasite Burden and Cytokine Balance in a Pre-Amazon Endemic Area from Brazil". Plos Neglected Tropical Diseases 10 3 (2016): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000373272500019&KeyUID=WOS:000373272500019.
    10.1371/journal.pntd.0004479
  25. Cassiano, Gustavo Capatti; Furini, Adriana A. C.; Capobianco, Marcela P.; Storti-Melo, Luciane M.; Almeida, Maria E.; Barbosa, Danielle R. L.; Povoa, Marinete M.; Nogueira, Paulo A.; Machado, Ricardo L. D.. "Immunogenetic markers associated with a naturally acquired humoral immune response against an N-terminal antigen of Plasmodium vivax merozoite surface protein 1 (PvMSP-1)". Malaria Journal 15 (2016): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000377180800001&KeyUID=WOS:000377180800001.
    10.1186/s12936-016-1350-2
  26. Moreira Batista Tomaz, Franciele Maira; da Cruz Furini, Adriana Antonia; Capobianco, Marcela Petrolini; Povoa, Marinete Marins; Alves Trindade, Pamella Cristina; Fraga, Valeria Daltibari; Conceicao, Luciana Moran; et al. "Humoral immune responses against the malaria vaccine candidate antigen Plasmodium vivax AMA-1 and IL-4 gene polymorphisms in individuals living in an endemic area of the Brazilian Amazon". Cytokine 74 2 (2015): 273-278. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000357704400015&KeyUID=WOS:000357704400015.
    10.1016/j.cyto.2015.03.020
  27. Cassiano, Gustavo Capatti; Melo Santos, Eduardo Jose; Thomaz Maia, Maria Helena; Furini, Adriana da Cruz; Storti-Melo, Luciane Moreno; Batista Tomaz, Franciele Maira; Alves Trindade, Pamella Cristina; et al. "Impact of population admixture on the distribution of immune response co-stimulatory genes polymorphisms in a Brazilian population". Human Immunology 76 11 (2015): 836-842. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000365142200009&KeyUID=WOS:000365142200009.
    10.1016/j.humimm.2015.09.045
  28. Capobianco, Marcela P.; Cassiano, Gustavo C.; Furini, Adriana A. C.; Storti-Melo, Luciane M.; Pavarino, Erika C.; Galbiatti, Ana L. S.; Fraga, Valeria D.; et al. "No evidence for association of the CD40, CD40L and BLYS polymorphisms, B-cell co-stimulatory molecules, with Brazilian endemic Plasmodium vivax malaria". Transactions of the Royal Society of Tropical Medicine and Hygiene 107 6 (2013): 377-383. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000319430100008&KeyUID=WOS:000319430100008.
    10.1093/trstmh/trt031
  29. Storti-Melo, Luciane Moreno; da Costa, Daniela Reis; Souza-Neiras, Wanessa Christina; Cassiano, Gustavo Capatti; D'Almeida Couto, Vanja Suely Calvosa; Povoa, Marinete Marins; Soares, Irene da Silva; et al. "Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax". Acta Tropica 121 2 (2012): 152-155. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000300132800014&KeyUID=WOS:000300132800014.
    10.1016/j.actatropica.2011.10.009
  30. Cassiano, Gustavo Capatti; Storti-Melo, Luciane Moreno; Povoa, Marinete Marins; Ribeiro Galardo, Allan Kardec; Baptista Rossit, Andrea Regina; Dantas Machado, Ricardo Luiz. "Development of PCR-RFLP assay for the discrimination of Plasmodium species and variants of P. vivax (VK210, VK247 and P. vivax-like) in Anopheles mosquitoes". Acta Tropica 118 2 (2011): 118-122. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000291182700008&KeyUID=WOS:000291182700008.
    10.1016/j.actatropica.2011.02.011
  31. Storti-Melo, Luciane M.; Souza-Neiras, Wanessa C.; Cassiano, Gustavo C.; Taveira, Leonardo C.; Cordeiro, Antonio J.; Couto, Vanja S. C. A.; Povoa, Marinete M.; et al. "Evaluation of the Naturally Acquired Antibody Immune Response to the Pv200L N-terminal Fragment of Plasmodium vivax Merozoite Surface Protein-1 in Four Areas of the Amazon Region of Brazil". American Journal of Tropical Medicine and Hygiene 84 2 (2011): 58-63. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000287004100009&KeyUID=WOS:000287004100009.
    10.4269/ajtmh.2011.10-0044
  32. Carvalho, D. B.; de Mattos, L. C.; Souza-Neiras, W. C.; Bonini-Domingos, C. R.; Cosimo, A. B.; Storti-Melo, L. M.; Cassiano, G. C.; et al. "Frequency of ABO blood group system polymorphisms in Plasmodium falciparum malaria patients and blood donors from the Brazilian Amazon region". Genetics and Molecular Research 9 3 (2010): 1443-1449. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000280397000018&KeyUID=WOS:000280397000018.
    10.4238/vol9-3gmr803
  33. Souza-Neiras, Wanessa C.; Storti-Melo, Luciane M.; Cassiano, Gustavo C.; Couto, Vanja S. C. A.; Couto, Alvaro A. R. A.; Soares, Irene S.; Carvalho, Luzia H.; et al. "Plasmodium vivax circumsporozoite genotypes: a limited variation or new subspecies with major biological consequences?". Malaria Journal 9 (2010): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000280170500002&KeyUID=WOS:000280170500002.
    10.1186/1475-2875-9-178
  34. Storti-Melo, Luciane M.; de Souza-Neiras, Wanessa C.; Cassiano, Gustavo C.; Joazeiro, Ana C. P.; Fontes, Cor J.; Bonini-Domingos, Claudia R.; D'Almeida Couto, Alvaro A. R.; et al. "Plasmodium vivax circumsporozoite variants and Duffy blood group genotypes in the Brazilian Amazon region". Transactions of the Royal Society of Tropical Medicine and Hygiene 103 7 (2009): 672-678. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000267610900006&KeyUID=WOS:000267610900006.
    10.1016/j.trstmh.2008.07.018

Other

Other output
  1. Molecular investigation of zoonotic genotypes of Giardia intestinalis isolates in humans, dogs and cats, sheep, goats and cattle in Araçatuba (São Paulo State, Brazil) by analysis of beta-giardin gene fragments. 2013. De Godoy, Elenir Alves Macedo; Santos Junior, Juarez Elias; Belloto, Marcus Vinicius Teresa; De Moraes, Marcus Vinicius Proença; Cassiano, Gustavo Capatti; Volotão, Aline Cardoso Caseca; Luvizotto, Maria Cecília Rui; et al.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020 Artificial intelligence to accelerate anti-malarial drug discovery Fourth GHTM Antimicrobial Resistance Awareness Day
2020 Identifying drugs against malaria X Simpósio de Biomedicina
2018 Computer-aided drug discovery approaches against malaria Global Health & Tropical Medicine Sessions
2015 Polymorphisms in B cell co-stimulatory genes are associated with IgG antibody responses against blood-stage proteins of Plasmodium vivax XIV Reunião Nacional de Pesquisa em Malária

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2024/01/01 - Current Assessment of the Activity of New 4-Quinolone Compounds against Hepatic and Sexual Forms of Plasmodium spp.
Co-supervisor
Universidade Federal de São Paulo, Brazil
2023 - Current High-throughput screening for novel antimalarials
Supervisor
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
2022 - Current Investigação da atividade antiplasmodial de compostos contra aurora quinase-2 de Plasmodium spp
Co-supervisor
Universidade Estadual de Campinas, Brazil
2018/02/01 - Current Família de proteínas NIMA/NEK de Plasmodium vivax: Potenciais alvos para o controle da doença
Co-supervisor
Universidade Estadual de Campinas, Brazil
2019 - 2023 Investigação da atividade antimalárica e de alvos moleculares de compostos naturais identificados por quimioinformática contra Plasmodium vivax
Co-supervisor
2018/03/03 - 2021 Triagem virtual e validação experimental de inibidores da CK1 (caseína quinase 1) de Plasmodium spp. com potencial antimalárico
Co-supervisor
2017/06/01 - 2018/01/10 Identificação de inibidores da PfPKG (Proteína Quinase G) como potencial antimalárico
Supervisor
2010/01/01 - 2010/12/01 Frequência dos genótipos da proteína de Plasmodium vivax, em área de Mata Atlântica, Estado do Rio de Janeiro
Co-supervisor

Event organisation

Event name
Type of event (Role)
Institution / Organization
2023/01/01 - Current Seminars of the Malaria Research group (2023/01/01)
Seminar
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical Biblioteca, Portugal
2010/03/10 - 2010/12/12 XIII Simpósio de Genética (2010/11/10 - 2010/11/12)
2008/04/10 - 2008/12/12 XI Simpósio de Genética (2008/11/19 - 2008/11/21)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2023/05/03 - Current Scientic Visit to IHMT-NOVA (Open day)
Other
2023 - Current Moderator
Congress
6° Congresso Nacional de Medicina Tropical
2022/09/17 - Current International Microorganism Day
Exhibition
Drug Resistances: A macro challenge also with parasites!!!
Sociedade Portuguesa de Microbiologia, Portugal
2022 - Current Discovery of potent antimalarial 1,4-naphtoquinones identified from computational screening (Speaker)
Symposium
New Antimalarials: from drug discovery to clinical trials
Universidade de São Paulo, Brazil
2023/07/24 - 2023/07/28 Ciência Viva no Laboratório
Other
Malaria-causing parasites: visualization under optical microscopy, cultivation in human cells, analysis of the activity of new or repurposed drugs
Ciência Viva, Portugal
2022/08/01 - 2022/08/12 Ciência Viva no Laboratório
Other
Total Malaria: exploring parasites and hosts in the search for new malaria drugs
Ciência Viva, Portugal

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2023/12/23 The role of plasmepsin 2/3 gene amplifications in the adaption of the digestive vacuole on Plasmodium falciparum antimalarial resistance
(Thesis) Main arguer
Tiago da Costa Figueiredo (Master)
Universidade do Minho, Portugal
2023 Influência de polimorfismos nos genes IL-2, IL-6, IL-10 e TNF-a sobre os níveis de anticorpos naturalmente adquiridos contra antígenos candidatos a vacina antimalárica
(Thesis) Arguer
Lucas Tavares de Queiroz (Master)
Fundação Oswaldo Cruz, Brazil
2022 Caracterização molecular e avaliação do impacto da variabilidade genética nos epítopos de células B das proteínas candidatas vacinais de Plasmodium vivax: PvCyRPA (P. vivax cysteine-rich protective antigen) e Pvs25 (P. vivax ookinete surface protein)
(Thesis) Main arguer
Lana Bitencourt Chaves (PhD)
2021/01/27 Inteligência Artificial e abordagens computacionais aplicadas à descoberta de candidatos a fármacos antimaláricos para o tratamento e controle da transmissão de Plasmodium spp
(Thesis) Arguer
Sabrina Silva Mendonça (Master)
Universidade Federal de Goiás, Brazil
2021 Avaliação do polimorfismo genético das Proteínas de Superfície do Merozoíto de Ligação ao Duffy 1 e 2 (MSPDBL – 1 e MSPDBL – 2) de Plasmodium falciparum e o seu impacto nos epítopos imunodominantes de células B e T em áreas endêmicas brasileiras de malária Juliana Aline de Souza Lemos (Master)
2018/03/02 Influência de marcadores de hipóxia e da síntese de óxido nítrico no processo hemolítico em anemia falciforme (Hb SS) e malária por Plasmodium vivax Patricia Pereira do Nascimento (PhD)
2018/03/01 Análise comparativa das frequências alélicas e genotípicas dos polimorfismos da Glicose 6 fosfato desidrogenase em pacientes com malária vivax e indivíduos não maláricos de áreas endêmicas no Brasil Letícia Cardoso Orlandini (Master)
2018/03/01 Identificação de novos fármacos antimaláricos através de estratégia de quimiogenômica por reposicionamento e validação experimental Juliana Rodrigues (PhD)
2015/12/02 Avaliação de anticorpos anti-Toxoplasma gondii em portadores de beta hemoglobinopatias Marina Neves Ferreira (Other)
2015 Identificação de hemoglobinas variantes por HPLC: contribuição ao diagnóstico de hemoglobinopatias no Brasil Mariana Salvarani (Other)
2014/06/01 Variantes genéticas de CCR5 na doença de Chagas Crônica Cardíaca Digestiva Amanda Priscila de Oliveira (PhD)

Ad Hoc journal article review

Journal title (ISSN) Publisher
2023 - Current ACS Omega
2022 - Current Scientific Reports
2021 - Current Cells
2021 - Current Computational and Structural Biotechnology Journal
2021 - Current Gene Reports
2018 - Current Microbial Pathogenesis
2016 - Current Clinical and Experimental Immunology (Print)
2012 - Current Revista do Instituto de Medicina Tropical de São Paulo (Impresso)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2017/05/08 - 2017/05/19 Abordagem Atualizada de Temas em Imunologia
Distinctions

Award

2017 Prof Dr William Barbosa
Universidade Federal de Goiás, Brazil