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Invited Assistant Professor, School of Medicine, University of Minho, Braga, Portugal. Graduation in biology, University of Porto, Portugal; PhD in neuro-oncology, IARC, France; Post-doc in cancer genomics, IPATIMUP / Portugal and VUMC / The Netherlands. Researcher productivity CNPq 1B. Scientific Director of the Research and Teaching Institute (IEP) and Coordinator of the Molecular Oncology Research Center (CPOM) of Barretos Cancer Hospital, Barretos, SP. Brazil.Extraordinary Professor, at Pan African Cancer Research Institute, University of Pretoria, South Africa.
Identification

Personal identification

Full name
RUI MANUEL VIEIRA REIS

Citation names

  • Reis, RM
  • Reis, Rui Manuel

Author identifiers

Ciência ID
FB1F-DC2C-25D4
ORCID iD
0000-0002-9639-7940
Google Scholar ID
PLkVSekAAAAJ
Researcher Id
B-1744-2018
Scopus Author Id
8203632800

Addresses

  • Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese (Mother tongue)
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2002 - 2003
Concluded
 Health Sciences (Pós-doutoramento)
Major in Human and Medical Genetics
VU Medisch Centrum, Netherlands

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
1998 - 2002
Concluded
 Biologia Humana (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal

International Agency for Research on Cancer, France
"Genetic alterations associated with development of human diffusely infiltrating astrocytomas" (THESIS/DISSERTATION)
1991 - 1995
Concluded
 Biologia (Licenciatura)
Universidade do Porto, Portugal
"Involvement of Mycoplasma-like Organisms (MLO) as a causal agent for the Yellwos disease in Rubus plants" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2011 - Current Coordinating Researcher (Research) Hospital de Amor, Brazil
Centro de Pesquisa em Oncologia Molecular, Brazil
2010/05 - Current Principal Investigator (Research) Hospital de Amor, Brazil
Centro de Pesquisa em Oncologia Molecular, Brazil
2003 - Current Principal Investigator (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2002 - 2003 Postdoc (Research) VU Medisch Centrum, Netherlands
2001 - 2003 Researcher (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2020 - Current Associate Professor (University Teacher) Universidade do Minho, Portugal
2010 - 2019 Invited Assistant Professor (University Teacher) Universidade do Minho, Portugal
2003 - 2010 Assistant Professor (University Teacher) Universidade do Minho, Portugal

Positions / Appointments

Category
Host institution 		Employer
2021/09 - Current Extraordinary Professor University of Pretoria, South Africa
Pan African Cancer Research Institute, South Africa
2019 - 2021/12/13 Pro-Rector Hospital de Amor, Brazil

Others

Category
Host institution 		Employer
2015 - Current Scientific Director- IEP Hospital de Amor, Brazil
2018 - 2021/12/01 Executive Director- IEP Hospital de Amor, Brazil
2015 - 2019 Coordinator of PIBIC Hospital de Amor, Brazil
1998 - 2001 PhD Student International Agency for Research on Cancer, France
1996 - 1997 Young Reasearch Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Projects

Grant

Designation Funders
2018 - Current Embryonic T-box transcription factor Brachyury: Dissecting its role in prostate cancer biology and clinical application
PTDC/MED-ONC/31423/2017
Principal investigator
Universidade do Minho Escola de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2016 - Current O conceito de moléculas-combinadas: uma nova abordagem no tratamento de câncer de pulmão avançado
Cancer research UK grants
Researcher
Cancer Research UK
Ongoing
2014 - Current Avaliação do câncer ocupacional e do potencial risco em trabalhadores rurais expostos a agentes carcinogênicos ambientais e ocupacionais na região de Barretos
Chamamento Publico n°20 – Estudos e Pesquisas Aplicadas em Vigilância em Saúde
Researcher
Ministério da Saúde
Ongoing
2013 - Current Estudo do papel biológico e terapêutico da Raf kinase inhibitor protein (RKIP) em GISTs e sua correlação com o fenótipo de instabilidade de microssatélites (MSI)
14/2013
Principal investigator
Fundação de Amparo à Pesquisa do Estado de São Paulo
Ongoing
2013 - Current Estudo funcional da modulação dos miRNAs, miR-451 e miR-720, em linhagens celulares de tumores humanos
12/23326-6
Researcher
Centro de Pesquisa em Oncologia Molecular, Brazil
 Fundação de Amparo à Pesquisa do Estado de São Paulo
Ongoing
2010/01/01 - Current Cell-intrinsic and microenvironmental signals intertwined: novel targets for therapeutic intervention in acute lymphoblastic leukemia?
info:eu-repo/grantAgreement/FCT/3599-PPCDT/104816/PT
Researcher
Instituto de Medicina Molecular, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
2010 - Current Role of WNK2 as a tumours suppressor gene in malignant gliomas
PTDC/SAU-OBD/100079/2008
Researcher
Ongoing
2006 - Current Molecular Profile of Portuguese GISTs
NOVASTIS2006
Researcher
Novartis Farma SA
Ongoing
2023/05/01 - 2025/05/01 PAPEL DA CD24, UMA PROTEÍNA DO “CHECKPOINT” IMUNOLÓGICO, NA BIOLOGIA E TERAPIA DE MEDULOBLASTOMAS
FROC_ICVS_2023
Principal Investigator
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Ongoing
2016 - 2019 PersonalizedNOS: New avenues for the development of personalized medical interventions for neurological, oncologic and surgical disorders
NORTE-01-0145-FEDER-000013
Researcher
Comissao de Coordenacao e Desenvolvimento Regional do Norte
Concluded
2014 - 2016 BIOPLAT – Plataforma Brasileira para Estudos de Bioprospecção de compostos naturias com potencial anticâncer em fase pré-clínica
MCTI/FINEP/MS/SCTIE/DECIT-1302/13
Principal investigator
Finep
Concluded
2013 - 2015 Creation of large animal models to test the concepts of no scar, no radiation exposure approaches for minimally invasive surgery in the oncological field
NORTE-07-0124-FEDER-000017
Researcher
Comissao de Coordenacao e Desenvolvimento Regional do Norte
Concluded
2013 - 2015 Estudo do efeito antineoplásico de extratos e derivados de Euphorbia tirucalli em tumores cerebrais e células tronco tumorais cerebrais
MCTI/CNPq Nº 73/2013
Principal investigator
Conselho Nacional de Desenvolvimento Científico e Tecnológico
2012 - 2015 Estudo pré-clinico dos potenciais compostos anti-neoplásicos AM10 e AM11
Amazônia Fitomedicamentos
Principal investigator
Centro de Pesquisa em Oncologia Molecular, Brazil
 Amazônia Fitomedicamentos
2011/04/01 - 2014 The Transcriptome of the Oncogenic HOXA9 Homeoprotein in Human Glioblastoma: Characterization and Functional Significance
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/113795/PT
Researcher
Universidade do Minho Escola de Medicina, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluded
2011/02/01 - 2014 Identification of novel target genes in microsatellite unstable brain tumours
info:eu-repo/grantAgreement/FCT/5876-PPCDTI/115513/PT
Principal investigator
Universidade do Minho Escola de Medicina, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluded
2011 - 2014 Potential predictive biomarkers of anti-RTKs therapy response in gliomas: An “in vitro” and “in vivo” Study
PTDC/SAU-TOX/114549/2009
Principal investigator
Universidade do Minho Escola de Medicina, Portugal
Concluded
2012 - 2013 Caracterização da instabilidade genômica em glioblastomas: identificação e elucidação de novas vias moleculares em tumores e culturas primárias
CNPq Nº 014/2011
Principal investigator
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Concluded
2011 - 2013 Avaliação do papel de microRNAs diferencialmente expressos no controle de invasão e metástase do câncer de mama
10/16796-0
Researcher
Hospital do Câncer de Barretos. Fundação Pio XII (FP), Brazil
 Fundação de Amparo à Pesquisa do Estado de São Paulo
Concluded
2010 - 2012 Implantação do Centro de Pesquisa Translacional em Oncologia
CT-INFRA-02/2010
Principal investigator
Centro de Pesquisa em Oncologia Molecular, Brazil
 Finep
Concluded
2007 - 2009 Study of Therapeutic Target c-KIT in Brain Tumours
Prof. Francisco Gentil 2006
Researcher
Pfizer Biofarmacêutica Sociedade Unipessoal Lda
Concluded
2004 - 2009 Study of Molecular Predictive Factors of Chemotherapy Response in High-Grade Gliomas
Novartis2004
Researcher
Novartis Farma SA
Concluded
2003 - 2009 Analysis of Receptor Tyrosine Kinases in Uterine Cervix Cancer
Scheringh-Plough Grants
Researcher
Scheringh-Plough
Concluded
2002/12/01 - 2004 Application of microarray CGH for the study of chromosomal instability at different stages of gastric carcinogenesis
info:eu-repo/grantAgreement/FCT/POCI/41179/PT
Post-doc Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Cardoso-Carneiro, Diana; Raquel-Cunha, Ana; Pinheiro, Joana; Gabriela-Freitas, Maria; Fontão, Patrícia; Reis, Rui M.; Martinho, Olga; et al. "Implications of RKIP protein in cancer prognosis and therapy response: A literature update". In Prognostic and Therapeutic Applications of RKIP in Cancer, 389-414. Elsevier, 2020.
    Published • 10.1016/b978-0-12-819612-0.00020-1
  2. Santana, IV; da Silva, V; REIS, RUI. "Classificação Molecular do Câncer de Mama". In Câncer de Mama: Uma Filosofia de Tratamento - Breast Unit Barretos, 204-209. Thieme Revinter, 2018.
    Published
  3. De Mello, Ramon Andrade; Luis, Michael; Araújo, António; Reis, Rui Manuel; Hespanhol, Venceslau. "The Role of Angiogenesis in Non-small Cell Lung Cancer Tumor Behavior". In Biochemical Basis and Therapeutic Implications of Angiogenesis, 217-239. Springer International Publishing, 2017.
    Published • 10.1007/978-3-319-61115-0_10
  4. Fernandes, Ana C.; Caeiro, Cláudia; Miranda-Gonçalves, Vera; Cury, Fernanda; Damasceno, Margarida; REIS, RUI; Martinho, Olga. "Bevacizumab for Glioblastoma Treatment: Reviewing Biological and Clinical Hypothesis for its Success and Failures". In Anti-Angiogenesis Drug Discovery and Development, 175-226. Bentham Science Publishers, 2016.
    Published • 10.2174/9781681081557116030007
  5. Gonçalves, Vera Miranda; Baltazar, Fátima; Reis, Rui Manuel. "Brain Tumor Metabolism — Unraveling Its Role in Finding New Therapeutic Targets". In Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor, 83. InTech, 2015.
    Published • 10.5772/59606
  6. Paixao Becker, Aline; Scapulatempo-Neto, Cristovam; Neder, Luciano; Chimelli, Leila; Reis, Rui M.. "Pilocytic Astrocytoma: Anatomic, Pathological and Molecular Aspects". In Clinical Management and Evolving Novel Therapeutic Strategies for Patients with Brain Tumors, 127-143. InTech, 2013.
    Published • 10.5772/53956
  7. de Mello, Ramon Andrade; Luis, Michael; Araújo, António; Reis, Rui Manuel; Hespanhol, Venceslau. "Role of Genetic Polymorphisms in the Angiogenesis Pathway and Non-small-Cell Lung Cancer Tumor Behavior: Implications in Risk Assessment and Clinical Outcome". In Biochemical Basis and Therapeutic Implications of Angiogenesis, 381-403. Springer, New York, 2013.
    Published • 10.1007/978-1-4614-5857-9_20
  8. Viana-Pereira, Marta; Jones, Chris; Reis, Rui Manuel. "Pediatric High-Grade Glioma: Role of Microsatellite Instability". In Pediatric Cancer: Diagnosis, Therapy and Prognosis, 205-210. Springer, Dordrecht, 2012.
    Published • 10.1007/978-94-007-4528-5_22
  9. Nogueira-de-Souza, Naiara Correa; Almeida, José Reinaldo; Serrano, Sérgio V.; REIS, RUI. "BRAF in glioblastomas: Clinical implications". In Glioblastoma: Risk Factors, Diagnosis and Treatment Options, 227-240. Nova Science Publishers, Inc., 2012.
    Published
  10. Becker, AP; Caravina, G; Clara, C; REIS, RUI. "The Role of Immunohistochemistry in the Diagnostic and Prognostic of Glioblastoma Patients". In Glioblastoma: Risk Factors, Diagnosis and Treatment Options, 173-199. Nova Science Publishers, 2012.
    Published
  11. Martinho, Olga; Reis, Rui Manuel. "Malignant Gliomas: Role of Platelet-Derived Growth Factor Receptor A (PDGFRA)". In Tumors of the Central Nervous System, 109-118. Springer, Dordrecht, 2011.
    Published • 10.1007/978-94-007-0344-5_12
  12. Viana-Pereira, Marta; Jones, Chris; Reis, Rui M.. "Genetic Instability in Paediatric and Adult Brain Tumours". In Molecular Targets of CNS Tumors, 19. InTech, 2011.
    Published • 10.5772/19571
  13. Ohgaki, H.; Biernat, W.; REIS, RUI; Hegi, M.; Kleihues, P.. "Gliosarcoma". In WHO Classification of Tumours. Pathology and Genetics of Tumours of the Nervous System, 42-44. IARC Press, 2000.
    Published
Journal article
  1. Lorena Vázquez-Iglesias; Giovanna Maria Stanfoca Casagrande; Daniel García-Lojo; Letícia Ferro Leal; Tien Anh Ngo; Jorge Pérez-Juste; Rui Manuel Reis; Krishna Kant; Isabel Pastoriza-Santos. "SERS sensing for cancer biomarker: Approaches and directions". Bioactive Materials (2024): https://doi.org/10.1016/j.bioactmat.2023.12.018.
    10.1016/j.bioactmat.2023.12.018
  2. Perdomo, Sandra; Abedi-Ardekani, Behnoush; de Carvalho, Ana Carolina; Ferreiro-Iglesias, Aida; Gaborieau, Valérie; Cattiaux, Thomas; Renard, Hélène; et al. "The Mutographs biorepository: A unique genomic resource to study cancer around the world". Cell Genomics (2024): 100500. http://dx.doi.org/10.1016/j.xgen.2024.100500.
    10.1016/j.xgen.2024.100500
  3. Pedro De Marchi; Leticia Ferro Leal; Luciane Sussuchi da Silva; Rodrigo de Oliveira Cavagna; Flavio Augusto Ferreira da Silva; Vinicius Duval da Silva; Eduardo CA da Silva; et al. "Gene expression profiles (GEPs) of immuno-oncologic pathways as predictors of response to checkpoint inhibitors in advanced NSCLC". Translational Oncology (2024): https://doi.org/10.1016/j.tranon.2023.101818.
    10.1016/j.tranon.2023.101818
  4. Lidia Maria Rebolho Batista Arantes; Renato José Silva-Oliveira; Ana Carolina de Carvalho; Matias Eliseo Melendez; Bruna Pereira Sorroche; Renan de Jesus Teixeira; Katiane Tostes; et al. "Unveiling the role of MGMT and DAPK hypermethylation in response to anti-EGFR agents: Molecular insights for advancing HNSCC treatment". Head & Neck (2023): https://doi.org/10.1002/hed.27602.
    10.1002/hed.27602
  5. Cíntia Regina Niederauer Ramos; Renato José Silva Oliveira; Marcela Nunes Rosa; Ariane Stéfani Pereira; Renata Barbosa Vahia de Abreu; Andre van Helvoort Lengert; Rui Manuel Reis; et al. "RAD50 Deficient in a Breast Cancer Model Predicts Sensitivity to PARP Inhibitors". Current Cancer Drug Targets (2023): https://doi.org/10.2174/1568009623666230418101511.
    10.2174/1568009623666230418101511
  6. Wesley Wang; Zeynep Temerit Kumm; Cindy Ho; Ideli Zanesco-Fontes; Gustavo Texiera; Rui Manuel Reis; Horacio Martinetto; et al. "Unsupervised machine learning models reveal predictive clinical markers of glioblastoma patient survival using white blood cell counts prior to initiating chemoradiation". Neuro-Oncology Advances (2023): https://doi.org/10.1093/noajnl/vdad140.
    10.1093/noajnl/vdad140
  7. de Oliveira C; Martins SFF; Gonçalves PG; Limone GA; Longatto-Filho A; Reis RM; Bidinotto LT. "Low EGFL7 expression is associated with high lymph node spread and invasion of lymphatic vessels in colorectal cancer.". Scientific reports (2023): http://europepmc.org/abstract/med/37957249.
    10.1038/s41598-023-47132-6
  8. Paula Rohr; Isabela Campanelli dos Santos; André van Helvoort Lengert; Marcos Alves de Lima; Rui Manuel Reis; Fernando Barbosa, Jr; Henrique Cesar Santejo Silveira. "Absolute telomere length in peripheral blood lymphocytes of workers exposed to construction environment". International Journal of Environmental Health Research (2023): https://doi.org/10.1080/09603123.2022.2066069.
    10.1080/09603123.2022.2066069
  9. Campanella NC; Gomes INF; Alves ALV; Leal LF; Evangelista AF; Rosa MN; Melendez ME; et al. "Biological and therapeutic implications of RKIP in Gastrointestinal Stromal Tumor (GIST): an integrated transcriptomic and proteomic analysis.". Cancer cell international (2023): http://europepmc.org/abstract/med/37907993.
    10.1186/s12935-023-03102-6
  10. Oliveira AGS; Rocha MA; de Azevedo LS; Coelho ATM; Chagas RCR; Santos HB; Thomé RG; et al. "Tapirira guianensis is Selectively Cytotoxic, Induces Apoptosis to the Glioblastoma and Decreases Tumor Growth and Angiogenesis in vivo.". Planta medica (2023): http://europepmc.org/abstract/med/37832581.
    10.1055/a-2181-2569
  11. Klein MO; Francisco LFV; Gomes INF; Serrano SV; Reis RM; Silveira HCS. "Hazard assessment of antineoplastic drugs and metabolites using cytotoxicity and genotoxicity assays.". Mutation research. Genetic toxicology and environmental mutagenesis (2023): http://europepmc.org/abstract/med/37973299.
    10.1016/j.mrgentox.2023.503704
  12. Moreno DA; Bonatelli M; Antoniazzi AP; de Paula FE; Leal LF; Garcia FAO; de Paula AE; et al. "High frequency of WNT-activated medulloblastomas with CTNNB1 wild type suggests a higher proportion of hereditary cases in a Latin-Iberian population.". Frontiers in oncology (2023): http://europepmc.org/abstract/med/37746264.
    10.3389/fonc.2023.1237170
  13. Fares AF; Li Y; Jiang M; Brown MC; Lam ACL; Aggarwal R; Schmid S; et al. "Association between duration of smoking abstinence before non-small-cell lung cancer diagnosis and survival: a retrospective, pooled analysis of cohort studies.". The Lancet. Public health (2023): http://europepmc.org/abstract/med/37633678.
    10.1016/s2468-2667(23)00131-7
  14. Santos FA; Reis RM; Barroti LC; Pereira AAL; Matsushita MM; de Carvalho AC; Datorre JG; Berardinelli GN; Araujo RLC. "Overall Survival, BRAF, RAS, and MSI Status in Patients Who Underwent Cetuximab After Refractory Chemotherapy for Metastatic Colorectal Cancer.". Journal of gastrointestinal cancer (2023): http://europepmc.org/abstract/med/37608030.
    10.1007/s12029-023-00964-x
  15. Adhara Brandão Lima; Mariana Bisarro dos Reis; Marcus Matsushita; Monise Tadin dos Reis; Marco Antônio de Oliveira; Rui Manuel Reis; Denise Peixoto Guimarães. "Combined SEPT9 and BMP3 methylation in plasma for colorectal cancer early detection and screening in a Brazilian population". Cancer Medicine (2023): https://doi.org/10.1002/cam4.6224.
    10.1002/cam4.6224
  16. Katiane Tostes; Aléxia Polo Siqueira; Rui Manuel Reis; Leticia Ferro Leal; Lidia Maria Rebolho Batista Arantes. "Biomarkers for Immune Checkpoint Inhibitor Response in NSCLC: Current Developments and Applicability". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241511887.
    10.3390/ijms241511887
  17. Fabiana L. Vazquez; Henrique C. S. Silveira; Ubirani B. Otero; Thais T. Hosokawa; José Humberto T. G. Fregnani; Adhemar Longatto-Filho; Rui M. Reis. "The Usefulness of an Online Simplified Screening Questionnaire (SSQ) in Identifying Work-Related Cancers". Healthcare (2023): https://doi.org/10.3390/healthcare11111563.
    10.3390/healthcare11111563
  18. Esther Clavero; Jose Manuel Sánchez Maldonado; Angelica Macauda; Rob Ter Horst; Sampaio-Marques, B.; Artur Jurczyszyn; Alyssa Clay-Gilmour; et al. "Polymorphisms within Autophagy-Related Genes as Susceptibility Biomarkers for Multiple Myeloma: A Meta-Analysis of Three Large Cohorts and Functional Characterization". International Journal of Molecular Sciences (2023): https://www.mdpi.com/1422-0067/24/10/8500.
    10.3390/ijms24108500
  19. Andreas Untergasser; Jan Hellemans; Michael W. Pfaffl; Jan M. Ruijter; Maurice J. B. van den Hoff; Mihnea P. Dragomir; Douglas Adamoski; et al. "Disclosing quantitative RT-PCR raw data during manuscript submission: a call for action". Molecular Oncology (2023): https://doi.org/10.1002/1878-0261.13418.
    10.1002/1878-0261.13418
  20. Lorena R. Sousa; Ana Gabriela S. Oliveira; Antônio Arantes; João Gabriel M. Junqueira; Gerso P. Alexandre; Vanessa G. P. Severino; Rui Manuel Reis; Bonglee Kim; Rosy I. M. A. Ribeiro. "Acetogenins-Rich Fractions of Annona coriacea Suppress Human Glioblastoma Viability and Migration by Regulating Necroptosis and MMP-2 Activity In Vitro". Molecules (2023): https://doi.org/10.3390/molecules28093809.
    10.3390/molecules28093809
  21. Causin RL; Van Helvoort Lengert A; Gomes INF; De Freitas AJA; Rosa MN; Dos Reis R; Reis RM; Marques MMC. "MicroRNA-130a-3p inhibition suppresses cervical cancer cell progression.". Oncology reports (2023): http://europepmc.org/abstract/med/37052265.
    10.3892/or.2023.8546
  22. Cavagna RO; Pinto IA; Escremim de Paula F; Berardinelli GN; Sant'Anna D; Santana I; Da Silva VD; et al. "Disruptive and truncating TP53 mutations are associated with African-ancestry and worse prognosis in Brazilian patients with lung adenocarcinoma.". Pathobiology : journal of immunopathology, molecular and cellular biology (2023): http://europepmc.org/abstract/med/37031678.
    10.1159/000530587
  23. René Aloisio da Costa Vieira; Débora Sant'Anna; Ana Carolina Laus; Carlos Eduardo Bacchi; René Julias Costa Silva; Idam de Oliveira-Junior; Vinicius Duval da Silva; Rui Pereira; Rui Manuel Reis. "Genetic ancestry of 1.127 Brazilian breast cancer patients and its correlation with molecular subtype and geographic region". Clinical Breast Cancer (2023): https://doi.org/10.1016/j.clbc.2023.04.001.
    10.1016/j.clbc.2023.04.001
  24. Causin RL; Sussuchi da Silva L; Leal LF; Possati-Resende JC; Evangelista AF; Matsushita GM; Scapulatempo-Neto C; Tavares Guerreiro Fregnani JH; Reis RM. "The digital expression profile of BMP7, CDKN2C, HIST1H3G, and PKMYT1 genes improves high-grade cervical lesion detection in liquid-based cytology.". Cancer cytopathology (2023): http://europepmc.org/abstract/med/37069588.
    10.1002/cncy.22704
  25. Zantut-Wittmann DE; Barreto IS; Laus AC; Moreno DA; Moma CA; Maia FFR; Assumpção LVMD; Reis RM. "PD-L1 and MCL-1 markers and the relationship with prognostic characteristics of differentiated thyroid carcinoma.". Molecular and cellular endocrinology (2023): http://europepmc.org/abstract/med/37072108.
    10.1016/j.mce.2023.111931
  26. Cabral ERM; Pacanhella MF; Lengert AVH; Dos Reis MB; Leal LF; de Lima MA; da Silva ALV; et al. "Somatic mutation detection and KRAS amplification in testicular germ cell tumors.". Frontiers in oncology (2023): http://europepmc.org/abstract/med/37007070.
    10.3389/fonc.2023.1133363
  27. Zantut-Wittmann DE; Laus AC; Moreno DA; Barreto IS; Moma CA; Maia F; Etchebehere E; Assumpção L; Reis RM. "Extremely aggressive course in a poorly differentiated thyroid carcinoma presenting a double mutation of the TERT promoter.". The American journal of the medical sciences (2023): http://europepmc.org/abstract/med/36972734.
    10.1016/j.amjms.2023.03.019
  28. Marques RF; Moreno DA; da Silva L; Leal LF; de Paula FE; Santana I; Teixeira G; et al. "Digital expression profile of immune checkpoint genes in medulloblastomas identifies CD24 and CD276 as putative immunotherapy targets.". Frontiers in immunology (2023): https://doi.org/10.3389/fimmu.2023.1062856.
    10.3389/fimmu.2023.1062856
  29. Silva VAO; Marcela N. Rosa; Izabela Faria; Vital, PS; Ana Laura Vieira Alves; Adriane Evangelista; Giovanna B. Longato; et al. "Bio-Prospecting of Crude Leaf Extracts from Thirteen Plants of Brazilian Cerrado Biome on Human Glioma Cell Lines". Molecules (2023): https://www.mdpi.com/1420-3049/28/3/1394.
    10.3390/molecules28031394
  30. Ferreira NN; Miranda RR; Moreno NS; Pincela Lins PM; Leite CM; Leite AET; Machado TR; et al. "Using design of experiments (DoE) to optimize performance and stability of biomimetic cell membrane-coated nanostructures for cancer therapy.". Frontiers in bioengineering and biotechnology (2023): http://europepmc.org/abstract/med/36815878.
    10.3389/fbioe.2023.1120179
  31. Garcia FAO; Evangelista AF; Mançano BM; Moreno DA; Berardinelli GN; de Paula FE; Antoniazzi AP; et al. "Genomic profile of two Brazilian choroid plexus tumors by whole-exome sequencing.". Cold Spring Harbor molecular case studies (2023): http://europepmc.org/abstract/med/36963804.
    10.1101/mcs.a006245
  32. Giovanna Maria Stanfoca Casagrande; Marcela de Oliveira Silva; Rui Manuel Reis; Letícia Ferro Leal. "Liquid Biopsy for Lung Cancer: Up-to-Date and Perspectives for Screening Programs". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24032505.
    10.3390/ijms24032505
  33. René Aloisio da Costa Vieira; Débora Sant'Anna; Ana Carolina Laus; Rui Manuel Reis. "Ancestry and self-reported race in Brazilian breast cancer women". Revista da Associação Médica Brasileira (2023): https://doi.org/10.1590/1806-9282.20230767.
    10.1590/1806-9282.20230767
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  95. Brunhara, Bruno B.; Becker, Aline P.; Neder, Luciano; Gonçalves, Paola G.; Oliveira, Cristiane; Clara, Carlos A.; Reis, Rui M.; Bidinotto, Lucas T.. "Evaluation of the prognostic potential of EGFL7 in pilocytic astrocytomas". Neuropathology 41 1 (2021): 21-28. http://dx.doi.org/10.1111/neup.12698.
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    10.1007/s11060-020-03675-6
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    10.21037/tlcr-20-740
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    10.1016/j.envpol.2020.115857
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  102. de Oliveira Cavagna R; Leal LF; de Paula FE; Bernardinelli GN; Reis RM. "A PCR-Based Approach for Driver Mutation Analysis of EGFR, KRAS, and BRAF Genes in Lung Cancer Tissue Sections.". Methods in molecular biology (Clifton, N.J.) (2021): http://europepmc.org/abstract/med/33683689.
    10.1007/978-1-0716-1278-1_9
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    10.1021/acs.jpcc.0c09055
  105. Datorre, José Guilherme; de Carvalho, Ana Carolina; Guimarães, Denise Peixoto; Reis, Rui Manuel. "The Role of Fusobacterium nucleatum in Colorectal Carcinogenesis". Pathobiology (2020): 1-14. http://dx.doi.org/10.1159/000512175.
    10.1159/000512175
  106. Souza, Aline Gomes de; Bastos, Victor Alexandre F.; Fujimura, Patricia Tieme; Ferreira, Izabella Cristina C.; Leal, Letícia Ferro; da Silva, Luciane Sussuchi; Laus, Ana Carolina; et al. "Cell-free DNA promotes malignant transformation in non-tumor cells". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-78766-5.
    10.1038/s41598-020-78766-5
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    10.1038/s41598-020-78793-2
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  111. Evangelista, Adriane Feijó; de Menezes, Weder Pereira; Berardinelli, Gustavo Noriz; Dos Santos, Wellington; Scapulatempo-Neto, Cristovam; Guimarães, Denise Peixoto; Calin, George A.; Reis, Rui Manuel. "Pyknon-Containing Transcripts Are Downregulated in Colorectal Cancer Tumors, and Loss of PYK44 Is Associated With Worse Patient Outcome". Frontiers in Genetics 11 (2020): http://dx.doi.org/10.3389/fgene.2020.581454.
    10.3389/fgene.2020.581454
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    10.1007/s00428-020-02962-x
  113. Romualdo, Guilherme Ribeiro; Prata, Gabriel Bacil; da Silva, Tereza Cristina; Evangelista, Adriane Feijó; Reis, Rui Manuel; Vinken, Mathieu; Moreno, Fernando Salvador; Cogliati, Bruno; Barbisan, Luís Fernando. "The combination of coffee compounds attenuates early fibrosis-associated hepatocarcinogenesis in mice: involvement of miRNA profile modulation". The Journal of Nutritional Biochemistry 85 (2020): 108479. http://dx.doi.org/10.1016/j.jnutbio.2020.108479.
    Published • 10.1016/j.jnutbio.2020.108479
  114. Marczynski, Gabriella Taques; Laus, Ana Carolina; dos Reis, Mariana Bisarro; Reis, Rui Manuel; Vazquez, Vinicius de Lima. "Circulating tumor DNA (ctDNA) detection is associated with shorter progression-free survival in advanced melanoma patients". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-75792-1.
    10.1038/s41598-020-75792-1
  115. Ibáñez-Redín, Gisela; Joshi, Nirav; do Nascimento, Gustavo Freitas; Wilson, Deivy; Melendez, Matias E.; Carvalho, André L.; Reis, Rui Manuel; Gonçalves, Débora; Oliveira, Osvaldo N.. "Determination of p53 biomarker using an electrochemical immunoassay based on layer-by-layer films with NiFe2O4 nanoparticles". Microchimica Acta 187 11 (2020): http://dx.doi.org/10.1007/s00604-020-04594-z.
    10.1007/s00604-020-04594-z
  116. Souza, Cristiano P.; Cinegaglia, Naiara C.; Felix, Tainara F.; Evangelista, Adriane F.; Oliveira, Rogério A.; Hasimoto, Erica N.; Cataneo, Daniele C.; et al. "Deregulated microRNAs Are Associated with Patient Survival and Predicted to Target Genes That Modulate Lung Cancer Signaling Pathways". Cancers 12 9 (2020): 2711. http://dx.doi.org/10.3390/cancers12092711.
    10.3390/cancers12092711
  117. Leal, Leticia F.; Laus, Ana C.; Cavagna, Rodrigo; Paula, Flavia E.; Oliveira, Marco A.; Ribeiro, Dayana M.; Hassan, Fernanda M.; et al. "EGF +61 A>G polymorphism does not predict response to first-generation EGFR tyrosine kinase inhibitors in lung cancer patients". Thoracic Cancer 11 10 (2020): 2987-2992. http://dx.doi.org/10.1111/1759-7714.13628.
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  118. Guimarães, Denise Peixoto; Mantuan, Larissa Andreoli; de Oliveira, Marco Antonio; Junior, Raphael Luiz; Costa, Allini Mafra da; Rossi, Silvana; Fava, Gilberto; et al. "The Performance of Colorectal Cancer Screening in Brazil: The First Two Years of the Implementation Program in Barretos Cancer Hospital". Cancer Prevention Research 14 2 (2020): 241-252. http://dx.doi.org/10.1158/1940-6207.capr-20-0179.
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  119. Pinto, Filipe; Costa, Ângela M.; Andrade, Raquel P.; Reis, Rui Manuel. "Brachyury Is Associated with Glioma Differentiation and Response to Temozolomide". Neurotherapeutics 17 4 (2020): 2015-2027. http://dx.doi.org/10.1007/s13311-020-00911-9.
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  120. Arantes, Lidia Maria Rebolho Batista; Cruvinel-Carloni, Adriana; de Carvalho, Ana Carolina; Sorroche, Bruna Pereira; Carvalho, André Lopes; Scapulatempo-Neto, Cristovam; Reis, Rui Manuel. "TERT Promoter Mutation C228T Increases Risk for Tumor Recurrence and Death in Head and Neck Cancer Patients". Frontiers in Oncology 10 (2020): http://dx.doi.org/10.3389/fonc.2020.01275.
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  121. Hull, Rodney; Mbele, Mzwandile; Makhafola, Tshepiso; Hicks, Chindo; Wang, Shao Ming; Reis, Rui; Mehrotra, Ravi; et al. "A multinational review: Oesophageal cancer in low to middle-income countries (Review)". Oncology Letters (2020): http://dx.doi.org/10.3892/ol.2020.11902.
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  122. Jesus, Lais Machado; Reis, Mariana Bisarro; Carvalho, Raiany Santos; Scapulatempo Neto, Cristovam; Almeida, Gisele Caravina; Laus, Ana Carolina; Marczynski, Gabriella Taques; et al. "Feasibility of methylated ctDNA detection in plasma samples of oropharyngeal squamous cell carcinoma patients". Head & Neck 42 11 (2020): 3307-3315. http://dx.doi.org/10.1002/hed.26385.
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  123. Ferreira, Natália N.; Granja, Sara; Boni, Fernanda I.; Prezotti, Fabíola G.; Ferreira, Leonardo M. B.; Cury, Beatriz S. F.; Reis, Rui M.; Baltazar, Fátima; Gremião, Maria Palmira D.. "Modulating chitosan-PLGA nanoparticle properties to design a co-delivery platform for glioblastoma therapy intended for nose-to-brain route". Drug Delivery and Translational Research 10 6 (2020): 1729-1747. http://dx.doi.org/10.1007/s13346-020-00824-2.
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  124. Ibáñez-Redín, Gisela; Materon, Elsa M.; Furuta, Roberto H. M.; Wilson, Deivy; do Nascimento, Gustavo Freitas; Melendez, Matias E.; Carvalho, André L.; et al. "Screen-printed electrodes modified with carbon black and polyelectrolyte films for determination of cancer marker carbohydrate antigen 19-9". Microchimica Acta 187 7 (2020): http://dx.doi.org/10.1007/s00604-020-04404-6.
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  125. Perehudoff, Katrina; Vermandere, Heleen; Williams, Alex; Bautista-Arredondo, Sergio; De Paepe, Elien; Dias, Sonia; Gama, Ana; et al. "Universal cervical cancer control through a right to health lens: refocusing national policy and programmes on underserved women". BMC International Health and Human Rights 20 1 (2020): http://dx.doi.org/10.1186/s12914-020-00237-9.
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  126. da Silva, Luciane S.; Mançano, Bruna M.; de Paula, Flávia E.; dos Reis, Mariana B.; de Almeida, Gisele C.; Matsushita, Marcus; Junior, Carlos A.; et al. "Expression of GNAS, TP53, and PTEN Improves the Patient Prognostication in Sonic Hedgehog (SHH) Medulloblastoma Subgroup". The Journal of Molecular Diagnostics 22 7 (2020): 957-966. http://dx.doi.org/10.1016/j.jmoldx.2020.04.207.
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  127. Nunes, Higor Lopes; Tuttis, Katiuska; Serpeloni, Juliana Mara; Nascimento, Jessyane Rodrigues do; da Rocha, Claudia Quintino; Silva, Viviane Aline Oliveira; Lengert, André van Helvoort; Reis, Rui Manuel; de Syllos Cólus, Ilce Mara. "Characterization of the in vitro cytotoxic effects of brachydins isolated from Fridericia platyphylla in a prostate cancer cell line". Journal of Toxicology and Environmental Health, Part A 83 15-16 (2020): 547-558. http://dx.doi.org/10.1080/15287394.2020.1784339.
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  128. Hull, Rodney; Mbele, Mzwandile; Makhafola, Tshepiso; Hicks, Chindo; Wang, Shao-Ming; Reis, Rui; Mehrotra, Ravi; et al. "Cervical cancer in low and middle-income countries (Review)". Oncology Letters 20 3 (2020): 2058-2074. http://dx.doi.org/10.3892/ol.2020.11754.
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  129. de Carvalho, Ana Carolina; Perdomo, Sandra; dos Santos, Wellington; Fernandes, Gabriela Carvalho; de Jesus, Lais Machado; Carvalho, Raiany Santos; Scapulatempo-Neto, Cristovam; et al. "Impact of genetic variants in clinical outcome of a cohort of patients with oropharyngeal squamous cell carcinoma". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-66741-z.
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  130. Vinagre, João; Pinheiro, Jorge; Martinho, Olga; Reis, Rui Manuel; Preto, John; Soares, Paula; Lopes, José Manuel. "A 30-Year Long-Term Experience in Appendix Neuroendocrine Neoplasms—Granting a Positive Outcome". Cancers 12 6 (2020): 1357. http://dx.doi.org/10.3390/cancers12061357.
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  131. Soares, Andrey Coatrini; Soares, Juliana Coatrini; Paschoalin, Rafaella Takehara; Rodrigues, Valquiria Cruz; Melendez, Matias Eliseo; Reis, Rui M.; Carvalho, André Lopes; Mattoso, Luiz Henrique Capparelli; Oliveira, Osvaldo N.. "Immunosensors containing solution blow spun fibers of poly(lactic acid) to detect p53 biomarker". Materials Science and Engineering: C 115 (2020): 111120. http://dx.doi.org/10.1016/j.msec.2020.111120.
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  132. Faria, Raquel Santos; Silva, Hugo Delleon; Mello-Andrade, Francyelli; Pires, Wanessa Carvalho; de Castro Pereira, Flávia; de Lima, Aliny Pereira; de Fátima Oliveira Santos, Sônia; et al. "Ruthenium(II)/Benzonitrile Complex Induces Cytotoxic Effect in Sarcoma-180 Cells by Caspase-Mediated and Tp53/p21-Mediated Apoptosis, with Moderate Brine Shrimp Toxicity". Biological Trace Element Research 198 2 (2020): 669-680. http://dx.doi.org/10.1007/s12011-020-02098-8.
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  133. Pinto, Filipe; Costa, Ângela M; Santos, Gisele C; Matsushita, Marcus M; Costa, Sandra; Silva, Viviane AO; Miranda-Gonçalves, Vera; et al. "The T-box transcription factor brachyury behaves as a tumor suppressor in gliomas". The Journal of Pathology 251 1 (2020): 87-99. http://dx.doi.org/10.1002/path.5419.
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  134. Schmitt, Julie; Goodfellow, Elliot; Huang, Shanlong; Williams, Christopher; Gomes, Izabela N.F.; Rosa, Marcela N.; Reis, Rui M.; et al. "Comparative analysis of the dual EGFR-DNA targeting and growth inhibitory properties of 6-mono-alkylamino- and 6,6-dialkylaminoquinazoline-based type II combi-molecules". European Journal of Medicinal Chemistry 192 (2020): 112185. http://dx.doi.org/10.1016/j.ejmech.2020.112185.
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  139. Marta Viana-Pereira; Daniel Antunes Moreno; Paulo Linhares; Júlia Amorim; Rui Nabiço; Sandra Costa; Rui Vaz; Rui Manuel Reis. "Replication of GWAS identifies RTEL1, CDKN2A/B, and PHLDB1 SNPs as risk factors in Portuguese gliomas patients". Molecular Biology Reports (2020): https://doi.org/10.1007/s11033-019-05178-8.
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  147. Juliana Coatrini Soares; Matias Eliseo Melendez; Andrey Coatrini Soares; Lidia Maria Rebolho Batista Arantes; Valquiria da Cruz Rodrigues; Andre Lopes Carvalho; Rui Manuel Reis; et al. "Detection of HPV16 in cell lines deriving from cervical and head and neck cancer using a genosensor made with a DNA probe on a layer-by-layer matrix". Materials Chemistry Frontiers 4 11 (2020): 3258-3266. https://doi.org/10.1039/D0QM00530D.
    Accepted • 10.1039/D0QM00530D
  148. Yollanda E. M. Franco; Marcia Y. Okubo; Adriana D. Torre; Paula P. Paiva; Marcela N. Rosa; Viviane A. O. Silva; Rui M. Reis; et al. "Coronarin D Induces Apoptotic Cell Death and Cell Cycle Arrest in Human Glioblastoma Cell Line". Molecules (2019): https://doi.org/10.3390/molecules24244498.
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  149. Wellington dos Santos; Thais Sobanski; Ana Carolina de Carvalho; Adriane Feijó Evangelista; Marcus Matsushita; Gustavo Nóriz Berardinelli; Marco Antonio de Oliveira; Rui Manuel Reis; Denise Peixoto Guimarães. "Mutation profiling of cancer drivers in Brazilian colorectal cancer". Scientific Reports (2019): https://doi.org/10.1038/s41598-019-49611-1.
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  378. Lima-Ramos, V.; Pacheco-Figueiredo, L.; Costa, S.; Pardal, F.; Silva, A.; Amorim, J.; Lopes, J. M.; et al. "TP53 codon 72 polymorphism in susceptibility, overall survival, and adjuvant therapy response of gliomas.". Cancer Genet Cytogenet 180 1 (2008): 14-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-36749023402&partnerID=MN8TOARS.
    S0165-4608(07)00586-9 [pii]10.1016/j.cancergencyto.2007.08.019
  379. Buffart, T.E.; Carvalho, B.; Mons, T.; Reis, R.M.; Moutinho, C.; Silva, P.; van Grieken, N.C.T.; et al. "DNA copy number profiles of gastric cancer precursor lesions". BMC Genomics 8 (2007): 345-345. http://www.scopus.com/inward/record.url?eid=2-s2.0-37249020215&partnerID=MN8TOARS.
    10.1186/1471-2164-8-345
  380. Schmitt, F.C.; Gomes, A.L.; Milanezi, F.; Reis, R.; Bardales, R.H.. "Mutations in gastrointestinal stromal tumors diagnosed by endoscopic ultrasound-guided fine needle aspiration". Minerva Medica 98 4 (2007): 385-388. http://www.scopus.com/inward/record.url?eid=2-s2.0-36749056265&partnerID=MN8TOARS.
  381. Gomes, A.L.; Reis-Filho, J.S.; Lopes, J.M.; Martinho, O.; Lambros, M.B.K.; Martins, A.; Schmitt, F.; Pardal, F.; Reis, R.M.. "Molecular alterations of KIT oncogene in gliomas". Cellular Oncology 29 5 (2007): 399-408. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547858153&partnerID=MN8TOARS.
  382. Gomes, A.L.; Bardales, R.H.; Milanezi, F.; Reis, R.M.; Schmitt, F.; Gomes, A. L.; Bardales, R. H.; Reis, R. M.. "Molecular analysis of c-Kit and PDGFRA in GISTs diagnosed by EUS". American Journal of Clinical Pathology 127 1 (2007): 89-96. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249077294&partnerID=MN8TOARS.
    10.1309/M1EC8JE9ACAMJACU
  383. Costa, B.M.; Ferreira, P.; Costa, S.; Canedo, P.; Oliveira, P.; Silva, A.; Pardal, F.; et al. "Association between functional EGF+61 polymorphism and glioma risk". Clinical Cancer Research 13 9 (2007): 2621-2626. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249104304&partnerID=MN8TOARS.
    10.1158/1078-0432.CCR-06-2606
  384. Carvalho, B.; Buffart, T.E.; Reis, R.M.; Mons, T.; Moutinho, C.; Silva, P.; Van Grieken, N.C.T.; et al. "Mixed gastric carcinomas show similar chromosomal aberrations in both their diffuse and glandular components". Cellular Oncology 28 5-6 (2006): 283-294. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845636631&partnerID=MN8TOARS.
  385. Reis-Filho, J. S.; Pinheiro, C.; Lambros, M. B.; Milanezi, F.; Carvalho, S.; Savage, K.; Simpson, P. T.; et al. "EGFR amplification and lack of activating mutations in metaplastic breast carcinomas.". J Pathol 209 4 (2006): 445-53.
    10.1002/path.2004
  386. Sambade, C.; Berglund, M.; Lagercrantz, S.; Sällström, J.; Reis, R. M.; Enblad, G.; Glimelius, B.; Sundström, C.. "U-2940, a human B-cell line derived from a diffuse large cell lymphoma sequential to Hodgkin lymphoma.". Int J Cancer 118 3 (2006): 555-63.
    10.1002/ijc.21417
  387. Reis, R.M.; Reis-Filho, J.S.; Filho, A.L.; Tomarev, S.; Silva, P.; Lopes, J.M.; Reis, R. M.; et al. "Differential Prox-1 and CD 31 expression in mucousae, cutaneous and soft tissue vascular lesions and tumors". Pathology Research and Practice 201 12 (2005): 771-776. http://www.scopus.com/inward/record.url?eid=2-s2.0-30444456045&partnerID=MN8TOARS.
    10.1016/j.prp.2005.08.010
  388. Carvalho, I.; Milanezi, F.; Martins, A.; Reis, R. M.; Schmitt, F.; Reis, R.M.. "Overexpression of platelet-derived growth factor receptor alpha in breast cancer is associated with tumour progression.". Breast Cancer Res 7 5 (2005): R788-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644873490&partnerID=MN8TOARS.
    bcr1304 [pii]10.1186/bcr1304
  389. Basto, D.; Trovisco, V.; Lopes, J. M.; Martins, A.; Pardal, F.; Soares, P.; Reis, R. M.. "Mutation analysis of B-RAF gene in human gliomas.". Acta Neuropathol 109 2 (2005): 207-10.
    10.1007/s00401-004-0936-x
  390. Reis, R.M.; Martins, A.; Ribeiro, S.A.; Basto, D.; Longatto-Filho, A.; Schmitt, F.C.; Lopes, J.M.. "Molecular characterization of PDGFR-a/PDGF-A and c-KIT/SCF in gliosarcomas". Cellular Oncology 27 5-6 (2005): 319-326. http://www.scopus.com/inward/record.url?eid=2-s2.0-29244460120&partnerID=MN8TOARS.
  391. REIS, RUI; Lopes, José Manuel. "Genetic alterations of adult and paediatric astrocytic tumours". Revista de Neurología 38 (2004): 8-15.
    Published
  392. Reis, R.M.; Nakamura, M.; Masuoka, J.; Watanabe, T.; Colella, S.; Yonekawa, Y.; Kleihues, P.; Ohgaki, H.. "Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas". Acta Neuropathologica 101 4 (2001): 297-304. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035032855&partnerID=MN8TOARS.
  393. Reis, R.M.; Herva, R.; Brandner, S.; Koivukangas, J.; Mironov, N.; Bär, W.; Kleihues, P.; Ohgaki, H.. "Second primary glioblastoma". Journal of Neuropathology and Experimental Neurology 60 2 (2001): 208-215. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035111348&partnerID=MN8TOARS.
  394. Reis, R.M.; Hara, A.; Kleihues, P.; Ohgaki, H.. "Genetic evidence of the neoplastic nature of gemistocytes in astrocytomas". Acta Neuropathologica 102 5 (2001): 422-425. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034774966&partnerID=MN8TOARS.
  395. Reis, R.M.; Nakamura, M.; Masuoka, J.; Watanabe, T.; Colella, S.; Yonekawa, Y.; Kleihues, P.; Ohgaki, H.. "Erratum: Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas (Acta Neuropathologica (2001) vol. 101 (297-304))". Acta Neuropathologica 101 6 (2001): http://www.scopus.com/inward/record.url?eid=2-s2.0-0034914191&partnerID=MN8TOARS.
  396. Rui M. Reis; Dilek Könü-Lebleblicioglu; Jose Manuel Lopes; Paul Kleihues; Hiroko Ohgaki. "Genetic Profile of Gliosarcomas". The American Journal of Pathology 156 2 (2000): 425-432. http://dx.doi.org/10.1016/s0002-9440(10)64746-3.
    10.1016/s0002-9440(10)64746-3
  397. Fujisawa, H.; Reis, R.M.; Nakamura, M.; Colella, S.; Yonekawa, Y.; Kleihues, P.; Ohgaki, H.. "Loss of heterozygosity on chromosome 10 is more extensive in primary (de novo) than in secondary glioblastomas". Laboratory Investigation 80 1 (2000): 65-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033968345&partnerID=MN8TOARS.
  398. Alves, C.; Silva, F.; Gusmão, L.; Seruca, R.; Soares, P.; Reis, R. M.; Amorim, A.. "Extended structural variation of a pentanucleotide repeat in the GSTP1 gene: characterisation in a normal population and in thyroid and gastric tumours.". Eur J Hum Genet 8 7 (2000): 540-4.
    10.1038/sj.ejhg.5200486
  399. Huang, H.; Reis, R.; Yonekawa, Y.; Lopes, J.M.; Kleihues, P.; Ohgaki, H.. "Identification in human brain tumors of DNA sequences specific for SV40 large T antigen". Brain Pathology 9 1 (1999): 33-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032958518&partnerID=MN8TOARS.
  400. Fujisawa, H.; Kurrer, M.; Reis, R. M.; Yonekawa, Y.; Kleihues, P.; Ohgaki, H.. "Acquisition of the glioblastoma phenotype during astrocytoma progression is associated with loss of heterozygosity on 10q25-qter.". Am J Pathol 155 2 (1999): 387-94.
    S0002-9440(10)65135-8 [pii]10.1016/S0002-9440(10)65135-8
Preprint
  1. Junior JNA; Preto DD; Lazarini MEZN; de Lima MA; Bonatelli M; Berardinelli GN; Silva VDd; et al. "PD-L1 expression and microsatellite instability (MSI) in cancer of unknown primary site". 2023. http://europepmc.org/abstract/PPR/PPR765319.
    10.21203/rs.3.rs-3369856/v1
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/07/01 - Current RKIP-regulated miRNAs in Gastrointestinal Stromal Tumor (GIST
Supervisor
 Health Sciences (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019 - Current Identification of the gene expression profile in metastatic renal cell carcinomas treated with sunitinib and its predictive response value
Supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2019 - Current Design and Implementation of an Integrated Lung Cancer Screening and Prevention Program using Mobile Computed Tomography
Supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2019 - Current Methylation analysis of tumor suppressor genes SEPT9, NDRG4 and BMP3 in the plasma of participants in the colorectal cancer screening program at the Barretos Cancer Hospital
Co-supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2019 - Current Development and implementation of a control and process management system for the medical and multiprofessional home secretary
Supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2019 - Current RKIP protein as a novel predictor of EGFR targeted therapy response in lung cancer
Co-supervisor
 Health Sciences (PhD)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Hospital de Amor, Brazil
2018 - Current Development of a gene expression panel to predict lymph node involvement in patients with non-small cell lung cancer
Co-supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2018 - Current Applicability of a nomogram including clinical and molecular variables in the stratification of risk groups in pediatric medulloblastoma
Supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2018 - Current Identification of predictive biomarkers of response to treatment with temozolomide in glioblastoma
Supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2018 - Current Analysis of somatic changes in the number of DNA copies of renal clear cell carcinoma
Co-supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2018 - Current RKIP protein as metastatic and therapeutic biomarker in cervical cancer
Co-supervisor
 Health Sciences (PhD)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Hospital de Amor, Brazil
2018 - Current Molecular Profile Identification Associated With Response To Treatment With Immunological Checkpoints Inhibitors In Patients With Non-Small Cell Lung Cancer
Supervisor
 Oncology (PhD)
Hospital de Amor, Brazil
2017 - Current Study Of Biomarkers Response To Cetuximabe And Perspectives For The Use Of Anti-Egfr Combi-Molecules In Solid Tumors
Supervisor
 Oncology (PhD)
Hospital de Amor, Brazil
2017 - Current Recommended Low Risk Endometric Adenocarcinoma. Is There A Predictive Genetic Signature For This Population?
Co-supervisor
 Oncology (PhD)
Hospital de Amor, Brazil
2017 - Current Evaluation Of Braf Mutation As A Predictive Factor Of Benefit To Chemotherapy In Patients With Metastatic Or Locally Advanced Irresectable Cancer Treated With Cetuximab In The Barretos Cancer Hospital
Co-supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2015 - Current Molecular characterization of MTAP (Methylthioadenosine phosphorylase) and evaluation of its therapeutic potential in gliomas
Supervisor
 Oncology (PhD)
Hospital de Amor, Brazil
2022/01/02 - 2033/12/30 Characterization and biological impact of medulloblastomas immune profile
Supervisor
 Oncology (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2023/12/01 - 2026/12/31 Risco Genético de Cancro Colorretal Esporádico na Região do Minho: Um Estudo GWAS (Genome-Wide Association Study)
Supervisor
 Oncology (PhD)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021 - 2023 ValidaçãO de biomarcadores preditivos da resposta à temozolomida em glioblastomas.
Supervisor of Ideli Zanesco Fontes Baptista
Hospital de Amor, Brazil
2020 - 2023 Caracterização do efeito biológico do composto semissintético derivado de Euphorbia tirucalli in vitro e in vivo, a partir do estabelecimento de um modelo xenográfico derivado de pacientes com câncer de esôfago.
Supervisor of Ana Laura Vieira Alves
Hospital de Amor, Brazil
2020 - 2023 Avaliação da frequência e impacto clínico das laterações moleculares “drivers” em 1000 pacientes com c6ancer de pulmão de células não pequenas tratados no Hospital de Câncer de Barretos.
Supervisor of Rodrigo de Oliveira Cavagna
Hospital de Amor, Brazil
2020 - 2022 Associação da instabilidade de microssatélites (MSI) e vírus Epstein-Barr (EBV) com a resposta patológica em pacientes com adenocarcinoma gástrico submetidos a quimioterapia perioperatória com Flofox e Flot.
Supervisor of Diego Burgardt
Hospital de Amor, Brazil
2020 - 2022 Análise de Brotamento Tumoral como fator prognóstico em pacientes com carcinoma colorretal do Hospital de Câncer de Barretos.
Supervisor of Monise Tadin Reis
Hospital de Amor, Brazil
2016 - 2020 In vitro and in vivo characterization of the antineoplastic potential of natural plant extracts and derivatives in commercial and primary cervical tumor lines
Supervisor
 Oncology (PhD)
Hospital de Amor, Brazil
2018 - 2019 New Diagnostic Method for Detecting Alk / Ret / Ros1 Fusions in Patients with Lung Adenocarcinoma Without Mutations in Kras and Egfr Genes
Supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2018 - 2019 Dissecting chemotherapy resistance in prostate cancer: interplay between RKIP and androgen stimulation
Co-supervisor
 Health Sciences (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017 - 2019 Characterization of the involvement of the WNK2 protein in autophagic and endocytic vesicular traffic in gliomas
Supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2017 - 2019 Evaluation of expression and prognostic potential of genes present in the chr9p22.1-p21.3 locus in gliomas
Supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2017 - 2019 Analysis of the frequency of BRAF gene mutations and association with clinicopathological characteristics of patients with lung adenocarcinoma for future direction of clinical management with target therapy
Supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2017 - 2019 Post-doc supervision of Nathalia Campanella (FAPESP Fellowship)
Supervisor
Hospital de Amor, Brazil
2016 - 2019 Analysis of the hypermethylation profile of a panel of tumor suppressor genes in precursor lesions and colorectal cancer
Co-supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2016 - 2019 Mutational profile of an extensive panel of oncogenes and tumor suppressor genes in colorectal cancer and its precursor lesions
Co-supervisor
 Oncology (PhD)
Hospital de Amor, Brazil
2015 - 2019 Post-Doc Supervision of Olga Martinho (FCT Fellowship)
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017 - 2018 Study of functional role and therapeutic influence of the tumor suppressor gene SPINT2 in Melanoma
Co-supervisor
 Health Sciences (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017 - 2018 Post-doc supervision of Juliana Alves Uzuelli (FAPESP Fellowship)
Supervisor
Hospital de Amor, Brazil
2017 - 2018 Evaluation of potential RKIP and SDHB biomarkers in gastrointestinal stromal tumors (GISTs)
Supervisor
Hospital de Amor, Brazil
2016 - 2018 Genotypic frequency of the EGF + 61 A> G polymorphism and analysis of associated melanoma risk in a miscigenic population
Co-supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2016 - 2018 Detection of high-risk HPV DNA and analysis of the mutational status of the KRAS and PIK3Ca genes and the inflammatory cytokine panel in patients with esophageal cancer and chagasic megaesophagus with and without cancer
Co-supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2016 - 2018 Application of visual programming analysis methods to cervical cancer data from The Cancer Genome Atlas
Co-supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2011 - 2018 Post-Doc Supervision of Marta Viana Pereira (FCT Fellowship)
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015 - 2017 Epidemiological, clinical-pathological and therapeutic characterization and its correlation with the ethnic ancestry of Brazilian patients with colorectal cancer
Supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2015 - 2017 Evaluation Of Anti-Tumoral Partitioning Activity And Chlorophormal Fractions Of Miconia Chamissois naudin In Human Glioma Lines
Co-supervisor
 Biotechnology (Master)
Universidade Federal de São João del-Rei, Brazil
2015 - 2017 Evaluation of the antineoplastic activity of enriched fractions of Annona coroacea Mart. in gynecological strains
Co-supervisor
 Biotechnology (Master)
Universidade Federal de São João del-Rei, Brazil
2015 - 2017 Post-doc supervision of Carla Carolina Munari (CNPq Fellowship)
Supervisor
Hospital de Amor, Brazil
2013 - 2017 Elucidation of the molecular and clinical impact of microsatellite instability in patients with sporadic colorectal carcinoma at the Barretos Cancer Hospital.
Supervisor
 Oncolgy (PhD)
Hospital de Amor, Brazil
2014 - 2016 Expression of the AXL tyrosine kinase receptor in patients with metastatic renal cell carcinoma treated with sunitinib and its association with clinical and pathological outcomes
Supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2014 - 2016 Characterization of the antineoplastic potential of natural compounds and their derivatives in commercial, primary and brain tumor stem cells
Supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2014 - 2016 Mutational Characterization of KRAS and BRAF Oncogenes and Analysis of MSI in Precursor Lesions of Colorectal Cancer
Co-supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2014 - 2016 Monocarboxylate Transporters in gliomas: regulation and therapeutic implications
Co-supervisor
 Health Sciences (PhD)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014 - 2016 Study of prognostic and therapeutic response biomarkers in gastrointestinal stromal tumors (GISTs)
Supervisor
 Oncology (PhD)
Hospital de Amor, Brazil
2012 - 2016 Identification of new predictive biomarkers of the response to anti-EGFR therapy in solid tumors.
Supervisor
 Oncology (PhD)
Hospital de Amor, Brazil
2011 - 2016 Learning from the embryo: Understanding early embryonic T gene – Brachyury – impact in human tumorigenesis
Supervisor
 Health Sciences (PhD)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015 - 2015 Post-doc supervision of Giovanna Barbarini Longato (CNPq Fellowship)
Supervisor
Hospital de Amor, Brazil
2014 - 2015 Study of Mutations of the HDI-1 Gene in Gliomas
Supervisor
Hospital de Amor, Brazil
2014 - 2015 Potentiation studies of Eufol compost derived from the Euphorbia tirucalli plant encapsulated in zeolites as drug delivery systems for in vitro models of brain tumors
Supervisor
Hospital de Amor, Brazil
2013 - 2015 Post-Doc Supervision of Renata Costa Camargo (CNPq fellowship)
Supervisor
Hospital de Amor, Brazil
2012 - 2015 Assessment of the MAPK pathway in the oncogenesis of pilocytic astrocytomas
Supervisor
 Oncology (PhD)
Hospital de Amor, Brazil
2014 - 2014 Post-doc supervision of Rosana Antunes Silveira (CAPES Fellowship)
Supervisor
Hospital de Amor, Brazil
2012 - 2014 Post-doc supervision of Viviane Silva (Amazônia Fitomedicamentos Fellowship)
Supervisor
Hospital de Amor, Brazil
2010 - 2014 Head and Neck Squamous Cell Carcinoma: integrating genomic, epigenetic and transcriptomic data - from bench to clinical applications
Co-supervisor
 Health Sciences and Technology (PhD)
Universidade de Coimbra, Portugal
2009 - 2014 Identification of intragenic copy number alterations and fusion genes in paediatric glioblastoma
Co-supervisor
 Human Biology (PhD)
Universidade de Coimbra, Portugal
2011 - 2013 Study of the tumor suppressor gene, TP53, in squamous cell carcinoma of the esophagus associated with chagasic megaesophagus
Supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2011 - 2013 Cytogenetic and Molecular characterization of Primary Glioma Strains
Supervisor
 Oncology (Master)
Hospital de Amor, Brazil
2011 - 2013 Post-doc supervision of Lucas Tadeu Bidinotto (FAPESP Fellowship)
Supervisor
Hospital de Amor, Brazil
2009 - 2013 Study of the Influence of Polymorphisms in the Angiogenesis Pathway in Lung Cancer
Co-supervisor
 Human Biology (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2011 - 2012 Role of WNK2 protein kinase as a suppressor gene for malignant gliomas
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2011 - 2012 Potential predictive biomarkers of anti-RTKs therapy response in gliomas: An in vitro and in vivo Study
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2012 microRNAs in cancer: biological effects of microRNAs in colorectal cancer
Supervisor
 Health Sciences (PhD)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2012 Role of monocarboxylate transporters in the metabolic remodeling of glioblastomas
Co-supervisor
 Health Sciences (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2012 Study of Biomarkers of Proliferation and Neovascularization: Clinical, Imagiological and Molecular Correlation
Co-supervisor
 Clinical Sciences (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2008 - 2012 Exploitation of monocarboxylate transporters (MCTs) as potential therapeutic targets in brain tumours
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010 - 2011 Evaluation of inhibition of monocarboxylate transporters in gliomas
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2011 Post-doc supervision of Bruno Costa (FCT Fellowship)
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2011 RTKs and MAPK pathway alterations in solid tumors: dissecting prognostic and therapeutic biomarkers
Supervisor
 Health Sciences (PhD)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2011 Development of Computational Tools for the Integrated Analysis of DNA Microarray Data with Applications in Cancer Research
Co-supervisor
 Bioinformatics (PhD)
Universidade do Minho Departamento de Informática, Portugal
2007 - 2011 Study of New Potential Molecular Targets for Pediatric Brain Tumors Therapy
Supervisor
 Health Sciences (PhD)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010 - 2010 Study of SPINT2 methylation and correlation with MET tyrosine kinase receptor expression
Supervisor
 Biochemistry (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010 - 2010 Drug encapsulation in nanostructures: Application in tumor cell lines
Supervisor
 Chemistry (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010 - 2010 Influence of HOXA9 Expression in the Cellular Response to Chemotherapy
Supervisor
 Biochemistry (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2010 - 2010 HOXA9's role in the response of gliomas to temozolomide and radiotherapy
Supervisor
 Medicine (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2010 Role of tumour suppressor gene RKIP in solid tumors
Supervisor
 Health Sciences (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2010 Evaluation of Microsatellite Instability in Brain Tumors
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2009 Analysis of the G-174C polymorphism in the IL-6 gene in breast cancer
Supervisor
 Applied Biology (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2009 Association of the T-1237C polymorphism in the Toll Like Receptor 9 (TLR9) gene with susceptibility to the development of breast cancer and gliomas
Supervisor
 Medicine (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2009 Is the plexin B1 gene mutated in prostate cancer?
Supervisor
 Medicine (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2009 - 2009 Epigenetic and expression analysis of AP-2a in brain tumors
Supervisor
 Medicine (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2009 Establishment and characterization of two in vivo models for gliomagenesis
Supervisor
 Medical Sciences (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2009 Implementation of an integrative platform for gene expression data analysis
Co-supervisor
 Bioinformatics (Master)
Universidade do Minho Departamento de Informática, Portugal
2008 - 2009 Association between EGF + 61 polymorphism and risk for breast cancer
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2008 Evaluation of RKIP expression in glioblastomas
Supervisor
 Medicine (Specialization course)
Universidade do Minho Escola de Medicina, Portugal
2008 - 2008 Evaluation of the prognostic potential of the MGMT gene in glioblastomas at Hospital S.João
Supervisor
 Medicine (Specialization course)
Universidade do Minho Escola de Medicina, Portugal
2008 - 2008 Methylation study of the AP2-alpha gene in medulloblastomas
Supervisor
 Applied Biology (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2008 - 2008 Role of MGMT and HOXA9 in the prognosis of glioblastomas
Supervisor
 Applied Biology (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2008 Expression of tyrosine kinase receptors PDGFRa, KIT and VEGFR-2 in gliomas
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2008 TP53 mutations in Portuguese glioblastomas
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2008 Evaluation of KIT mutations in GISTs
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2005 - 2008 Molecular Determinants of Glioma Risk and Patient Prognosis
Supervisor
 Health Sciences (PhD)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2007 Analysis of TP53 mutations in gliomas
Supervisor
 Applied Biology (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2007 - 2007 Analysis of the potential of the liquid-based cytology medium for molecular studies
Supervisor
 Applied Biology (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2007 Analysis of c-kit changes in human tumors
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2007 Optimization of PDGFRA mutations in gliomas
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2006 Study of EGFR mutations in bladder carcinomas
Supervisor
 Applied Biology (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006 - 2006 Analysis of EGFR mutations in breast cancer
Supervisor
 Applied Biology (Degree)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2005 - 2006 Analysis of molecular changes in solid tumors
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2005 - 2006 Molecular changes in glial tumors
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2005 - 2006 Influence of epigenetic changes in response to chemotherapy in patients with gliomas
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2004 - 2005 Molecular Characterization of EGFRvIII and B-RAF Oncogenes in Gliomas
Supervisor
 Health Sciences (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2004 - 2005 Polymorphism analysis of TP53 (codon 72) in gliomas
Supervisor
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Committee member

Activity description
Role 		Institution / Organization
2011 - Current Member of the Post-graduation committee.
Member
 Hospital de Amor, Brazil

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2003/02 - Current Fundamentals of medical genetics. Health Sciences (Pós-Graduação) Universidade do Minho Escola de Medicina, Portugal
2003/02 - Current Genetics Medicine (Mestrado integrado) Universidade do Minho Escola de Medicina, Portugal
Distinctions

Award

2023 Best Translational Research Poster
A.C.Camargo Cancer Center, Brazil
2023 Best Poster Award
Associação Portuguesa de Neuro-Oncologia, Portugal
2022 Best Poster
XXIX Congresso de Pneumologia do Norte, Portugal
2021 Best Poster
XV Congresso da MutaGen-Brasil, Brazil
2021 Best oral presentation
Brazilian Breast Cancer Symposium, Brazil
2020 3rd Place, Oral Presentation
American Association for Cancer Research, United States
2019 Best Oral Presentation
Sociedade Brasileira de Patologia, Brazil
2019 Best Poster
ACCamargo Cancer Center, Brazil
2019 Best Poster
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018 Best Oral Presentation
Society for Neuro Oncology Latin America, Brazil
2017 Best Poster
2017 Awards SBP and EPOAHT
Sociedade Brasileira de Patologia, Brazil
2017 3rd place Prize for Best Work
Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, Brazil
2017 Best Oral Presentation
Sociedade Brasileira de Patologia, Brazil
2016 50-for-50: Empowering future cancer research leaders
International Agency for Research on Cancer, France
2015 Best Poster in the field of "Mecanismos de ação de drogas"
Sociedade Brasileira de Bioquímica e Biologia Molecular, Brazil

International Union of Biochemistry and Molecular Biology, Canada
2015 2nd place Prize for Best Oral Presentation
Hospital de Amor, Brazil
2015 Best Poster
Hospital de Amor, Brazil
2015 2nd place Prize for Best Poster
Hospital de Amor, Brazil
2015 Best article published in “Acta Urológica Portuguesa”
Sociedade Portuguesa de Neurologia, Portugal
2015 Best work of the session "Apresentação Oral / Temas Livres"
Sociedade Brasileira de Patologia, Brazil
2015 Best Poster in the field of "Bioquímica e Biologia Molecular dos Eucariotos Superiores"
Sociedade Brasileira de Bioquímica e Biologia Molecular, Brazil

International Union of Biochemistry and Molecular Biology, Canada
2014 Award Newton Freire-Maia - in genetics and human evolution and medical genetics
2014 2nd place Prize for the Best Poster
2014 2nd place Prize for the Best Oral Presentation
Sociedade Portuguesa de Oncologia, Portugal
2014 Best Oral Presentation
Hospital de Amor, Brazil
2014 2nd place Prize for the Best Oral Presentation
Hospital de Amor, Brazil
2014 Best Poster
Hospital de Amor, Brazil
2013 Best Poster
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2013 Best Oral Presentation
Hospital de Amor, Brazil
2013 Honor Mention
2012 Best Oral Presentation
2012 Travel Award
2012 “VII Prêmio Saúde Abril 2012”
2011 Best Poster in Translational Research
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2011 Merit Award
International Society of Oncology and Biomarkers, United Kingdom
2009 3rd place Prize for the Best Oral Presentation
2009 Best Poster
2009 2nd place Prize for the Best Oral Presentation in Oncology and Molecular Biology
Universidade do Porto Faculdade de Medicina, Portugal
2009 Best Poster in Oncology and Molecular Biology
Universidade do Porto Faculdade de Medicina, Portugal
2009 Best Oral Presentation
2009 Best Scientific Work
2007 1st Prize in Neurosciences
Universidade do Porto Faculdade de Medicina, Portugal
2006 1st Prize in Clinical Research
2006 1st Prize in Oncology
Universidade do Porto Faculdade de Medicina, Portugal
2006 1st Pfizer Prize in "Research in Oncology Diseases, Prof. Francisco Gentil"
2005 Best Poster
Sociedade Portuguesa de Oncologia, Portugal
1995 Highest classification in Biology at University of Porto
Fundação Engenheiro António de Almeida, Portugal