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Raquel Rodrigues Lopes. Conclui o Mestrado em Bioquímica com especialização em Bioquímica Médica em 2017 pela Universidade de Lisboa Faculdade de Ciências e Licenciatura em Bioquímica em 2014 pela Universidade do Algarve Faculdade de Ciências e Tecnologia. Sou Bolseira de Investigação na Universidade de Lisboa - Instituto de Investigação do Medicamento. Publiquei 3 artigos em revistas especializadas.
Identification

Personal identification

Full name
Raquel Rodrigues Lopes

Citation names

  • Lopes, Raquel Rodrigues

Author identifiers

Ciência ID
FC17-E40F-F42A
ORCID iD
0000-0002-4103-3752
Scopus Author Id
57211057251

Email addresses

  • rrlopes@ff.ulisboa.pt (Professional)
  • lopes.r.raquel@gmail.com (Personal)

Addresses

  • Rua do Sol, nº 10, 2510-191, Arelho, Óbidos, Óbidos, Portugal (Personal)

Knowledge fields

  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Elementary (A2) Intermediate (B1) Intermediate (B1) Elementary (A2)
Education
Degree Classification
2021/11 - 2025/11
Ongoing
 Bioquímica (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Proteostasis pathways of human phenylalanine hydroxylase" (THESIS/DISSERTATION)
2014 - 2017
Concluded
 Bioquímica (Mestrado)
Major in Bioquímica Médica
Universidade de Lisboa Faculdade de Ciências, Portugal
"Novas abordagens para o tratamento da fenilcetonúria: pequenas moléculas moduladoras da atividade e estabilidade da fenilalanina hidroxilase humana." (THESIS/DISSERTATION)
 17
2014
Concluded
 Bioquímica (Licenciatura)
Universidade do Algarve Faculdade de Ciências e Tecnologia, Portugal
"n/a" (THESIS/DISSERTATION)
 12
Affiliation

Science

Category
Host institution 		Employer
2021/11 - Current Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019/02 - 2021/10 Researcher (Research) Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Projects

Contract

Designation Funders
2019/02 - Current Targeting aromatic amino acid hydroxylases (AAAHs) to modulate disrupted homeostasis of catecholamines, serotonin and melatonin.
PTDC/MED-QUI/29712/2017
Research Fellow
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Conference abstract
  1. Lopes, Raquel Rodrigues. "Leandro J, Amaro MP, Paterna RR, Lopes R, Gomes K, Tavares de Almeida I, Góis PMP, Leandro P. "New generation of chemical scaffolds able to bind to human phenylalanine hydroxylase". J Inherit Metab Dis 39 (Suppl 1) S39.". Paper presented in Annual Symposium of SSIEM, Roma, 2016.
    Published
Conference poster
  1. Lopes, Raquel Rodrigues. "Borges A, Lopes RR, Padanha R, Russo R, Gonçalves L, Góis PMP, Leandro P. "Modulation of the in vitro aggregation of the full-length and a truncated form of p.G46S human phenylalanine hydroxylase by small molecules". 16th International Symposium of the Portuguese Society for Metabolic Disorders. 11-13 novembro 2020". 2020.
  2. Lopes, Raquel Rodrigues. "Dias A, Lopes RR, Gonçalves L, Corvo ML, Leandro P. "Modification of Lysine Residues of Human Phenylalanine Hydroxylase: effect on protein function and stability". 16th International Symposium of the Portuguese Society for Metabolic Disorders. 11-13 novembro 2020.". Paper presented in 16th International Symposium of the Portuguese Society for Metabolic Disorders., 2020.
  3. Lopes, Raquel Rodrigues. "Lopes RR, Paterna R, Russo R, Costa C, Leandro J, Gonçalves LM, Gois PMP, Leandro P. "Quinoline derivatives as a new class of modulators of human phenylalanine hydroxylase activity". 9th iMed.ULisboa Postgraduate Students Meeting & 2nd i3du Meeting, Lisboa (Portugal), 13-14 julho 2017.". Paper presented in 9th iMed.ULisboa Postgraduate Students Meeting & 2nd i3du Meeting, 2017.
  4. Lopes, Raquel Rodrigues. "Costa C, Paterna R, Lopes RR, Russo R, Gonçalves LMG, Leandro J, Gois PMP, Leandro P. "The Aggregation-Prone G46S Variant of Human Phenylalanine Hydroxylase as a Target for Regulators of Proteostasis Networks". 9th iMed.ULisboa Postgraduate Students Meeting & 2nd i3du Meeting, Lisboa (Portugal), 13-14 julho 2017.". Paper presented in 9th iMed.ULisboa Postgraduate Students Meeting & 2nd i3du Meeting, 2017.
  5. Lopes, Raquel Rodrigues. "Tortorella A, Lopes RR, Costa C, Gonçalves LMG, Leandro P, Almeida A. "Formulation of stabilized Human phenylalanine hydroxlase: A novel enzyme reposition therapy approach to PKU". 9th iMed.ULisboa Postgraduate Students Meeting & 2nd i3du Meeting, Lisboa (Portugal), 13-14 julho 2017.". Paper presented in 9th iMed.ULisboa Postgraduate Students Meeting & 2nd i3du Meeting, 2017.
  6. Lopes, Raquel Rodrigues. "Gomes K, Lopes RR, Leandro J, Gonçalves L, Almeida AJ, Leandro P. "Cellular uptake of human phenylalanine hydroxylase encapsulated in nanoparticles: towards a new approach to PKU treatment". 13th International Symposium of the Portuguese Society for Metabolic Disorders. Évora, Portugal, 16-18 março 2017.". Paper presented in 13th International Symposium of the Portuguese Society for Metabolic Disorders., 2017.
  7. Lopes, Raquel Rodrigues. "Lopes RR, Costa C, Leandro J, Amaro MP, Paterna R, Gois PMP, Leandro P. "Effect of quinoline derivatives on the activity of recombinant human phenylalanine hydroxylase". 13th International Symposium of the Portuguese Society for Metabolic Disorders. Évora, Portugal, 16-18 março 2017.". Paper presented in 13th International Symposium of the Portuguese Society for Metabolic Disorders., 2017.
  8. Lopes, Raquel Rodrigues. "Costa C, Moura S, Amaro MP, Paterna P, Lopes RR, Tavares de Almeida I, Gois PMP, Leandro P, Leandro J. "Identification of new pharmacological modulators of aggregation-prone variants of human phenylalanine hydroxylase". 13th International Symposium of the Portuguese Society for Metabolic Disorders. Évora, Portugal, 16-18 março 2017.". Paper presented in 13th International Symposium of the Portuguese Society for Metabolic Disorders., 2017.
Journal article
  1. Paula Leandro; Paulo R. Lino; Raquel Lopes; João Leandro; Mariana P. Amaro; Paulo Sousa; João B. Vicente; António J. Almeida. "Isothermal denaturation fluorimetry vs differential scanning fluorimetry as tools for screening of stabilizers for protein freeze-drying: Human phenylalanine hydroxylase as the case study". European Journal of Pharmaceutics and Biopharmaceutics (2023): https://doi.org/10.1016/j.ejpb.2023.03.012.
    10.1016/j.ejpb.2023.03.012
  2. Lopes, Raquel R.; Tomé, Catarina S.; Russo, Roberto; Paterna, Roberta; Leandro, João; Candeias, Nuno R.; Gonçalves, Lídia M. D.; et al. "Modulation of Human Phenylalanine Hydroxylase by 3-Hydroxyquinolin-2(1H)-One Derivatives". Biomolecules 11 3 (2021): 462. http://dx.doi.org/10.3390/biom11030462.
    Published • 10.3390/biom11030462
  3. Tomé, Catarina S.; Lopes, Raquel R.; Sousa, Pedro M. F.; Amaro, Mariana P.; Leandro, João; Mertens, Haydyn D. T.; Leandro, Paula; Vicente, João B.. "Author Correction: Structure of full-length wild-type human phenylalanine hydroxylase by small angle X-ray scattering reveals substrate-induced conformational stability". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-54425-2.
    10.1038/s41598-019-54425-2
  4. Tomé, Catarina S.; Lopes, Raquel R.; Sousa, Pedro M. F.; Amaro, Mariana P.; Leandro, João; Mertens, Haydyn D. T.; Leandro, Paula; Vicente, João B.. "Structure of full-length wild-type human phenylalanine hydroxylase by small angle X-ray scattering reveals substrate-induced conformational stability". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-49944-x.
    Open access
Thesis / Dissertation
  1. Lopes, Raquel Rodrigues. "Novas abordagens para o tratamento da fenilcetonúria: pequenas moléculas moduladoras da atividade e estabilidade da fenilalanina hidroxilase humana". Master, Universidade de Lisboa Faculdade de Farmácia, 2017.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/11 Lopes RR, Russo R, Padinha R, Tomé CS, Vicente JB, Gonçalves LM, Góis PMP, Leandro P. "Effect of small compounds on the activity and stability of recombinant human phenylalanine hydroxylase: in vitro and in cellulo studies". 16th International Symposium of the Portuguese Society for Metabolic Disorders (SPDM), Virtual Symposium, 11-13 novembro de 2020. 16th International Symposium of the Portuguese Society for Metabolic Disorders (SPDM)
(Portugal)
2019/03 Lopes RR, Russo R, Tomé C, Teixeira M, Vicente JB, Góis PMP, Leandro P. "Design of small molecules that increase human phenylalanine hydroxylases thermostability". 15th International Symposium of the Portuguese Society for Metabolic Disorders (SPDM), Coimbra, Portugal. 14-16 março de 2019 15th International Symposium of the Portuguese Society for Metabolic Disorders (SPDM)
(Coimbra, Portugal)
2018/03 Costa C, Lopes RR, Leandro J, Gonçalves L, Góis PMP, Leandro P. "Chemical scaffolds to modulate the activity and aggregation behavior of human phenylalanine hydroxylase". 14th International Symposium of the Portuguese Society for Metabolic Disorders (SPDM). Porto, Portugal. 15-17 março de 2018. 14th International Symposium of the Portuguese Society for Metabolic Disorders (SPDM)
(Porto, Portugal)
2016/09 Leandro J, Amaro MP, Paterna R, Lopes RR, Gomes K, Tavares de Almeida I, Góis PMP, Leandro P. "New generation of chemical scaffolds able to bind to human phenylalanine hydroxylase". Annual Symposium of SSIEM, Roma, Itália. 6-9 setembro de 2016. Annual Symposium of SSIEM
(Roma, Italy)

Association member

Society Organization name Role
2019/03 - Current Sociedade Portuguesa de Doenças Metabólicas
Distinctions

Award

2020 Melhor Comunicação Oral
Sociedade Portuguesa de Doenças Metabólicas, Portugal