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Catarina Barbosa-Matos graduated in Biochemistry at the School of Sciences, University of Minho in 2016 and completed her Master's degree in Health Sciences at the School of Medicine, University of Minho in 2018. From October 2018 to October 2019, Catarina worked as a research fellow at at the Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. In June 2024, she completed her PhD in Health Sciences at the ICVS which started in October 2019 after being awarded a Studentship for Doctorate Research by the Fundação para a Ciência e Tecnologia. During her PhD, she focused on investigating the role of c-MET in inflammatory and infectious lung diseases. Her track record is currently reflected in 10 publications in international peer-reviewed journals, two of them as first author.
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Identification

Personal identification

Full name
Ana Catarina Barbosa Matos
Date of birth
1995/06/14
Gender
Female

Citation names

  • Catarina Barbosa-Matos

Author identifiers

Ciência ID
FC18-0C1F-D50B
ORCID iD
0000-0003-1031-4241

Email addresses

  • ccatarinabm@gmail.com (Personal)

Addresses

  • Life and Health Sciences Research Institute (ICVS) Universidade do Minho Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Developmental Biology
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Health Sciences - Infectious Diseases

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2019/10 - 2024/06/04
Concluded
 Health Sciences (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
"Immunoregulatory role of c-MET in pulmonary disease" (THESIS/DISSERTATION)
2016/09 - 2018/10
Concluded
 Health Sciences (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
"Lung fibrosis regulation by c-Met-expressing immune cells" (THESIS/DISSERTATION)
 18
2017/01 - 2017/02
Concluded
 Laboratory Animals Sciences - Category C program according to FELASA recommendations (Curso de mestrado (conclusão do curso de especialização))
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 17
2013/09 - 2016/07
Concluded
 Biochemistry (Licenciatura)
Universidade do Minho Escola de Ciências, Portugal
 17
Affiliation

Science

Category
Host institution 		Employer
2024/05/01 - 2024/12/31 Postdoc (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/10/22 - 2019/10/22 Researcher (Research) Universidade do Minho Escola de Medicina, Portugal
2016/09/01 - 2018/09/10 Research Trainee (Research) Universidade do Minho Escola de Medicina, Portugal
2015/03/01 - 2016/07/01 Research Trainee (Research) Universidade do Minho Escola de Ciências, Portugal

Others

Category
Host institution 		Employer
2020/09 - 2021/12 Volunteer in SARS-Cov-2 detection tests Universidade do Minho Escola de Medicina, Portugal
Universidade do Minho Escola de Medicina, Portugal
Projects

Grant

Designation Funders
2019/10 - 2024/01 Immunoregulatory role of c-Met in pulmonary disease
SFRH/BD/145955/2019
COVID/BD/153456/2023
PhD Student Fellow
Ongoing
Outputs

Publications

Conference abstract
  1. Fernandes, Raquel; Barbosa-Matos, Catarina; Borges-Pereira, Caroline; Costa, Sandra. "Glycogen synthase kinase-3 inhibition by CHIR99021 promotes alveolar epithelial cell proliferation and lung regeneration in acute lung injury". Paper presented in Repair and regeneration in chronic lung disease and lung cancer, 19th ERS Lung Science Conference, 2021.
    Published • 10.1183/23120541.lsc-2021.88
  2. Catarina Barbosa-Matos; Caroline Borges-Pereira; Sofia Libório-Ramos; Massimiliano Mazzone; Sandra Costa. "c-Met expression induction in immune cells modulates pulmonary fibrosis progression". Paper presented in 2020 ERS International Congress, 2020.
    Published • 10.1183/13993003.congress-2020.2583
Conference poster
  1. Barbosa-Matos, Catarina; Duarte-Oliveira, Cláudio; Machado, Ana; Gonçalves, Samuel M.; Silva-Gomes, Rita; Fernandes, Raquel; Caldeira, Inês; et al. "Recognition of Aspergillus fumigatus by c-MET is required for protective immunity against infection.". Paper presented in XLIX Annual Meeting of the Portuguese Society for Immunology, 2024.
  2. Cláudio Duarte-Oliveira; Sara Silva-Ferreira; Daniela Antunes; Catarina Barbosa-Matos; Ana Mendes-Frias; Egídio Torrado; Sandra Costa; et al. "Innate Regulation of Antifungal Immunity in Chronic Pulmonary Aspergillosis". Paper presented in Fungal update: Mycology Conference 2023, 2023.
  3. Barbosa-Matos, Catarina; Duarte-Oliveira, Cláudio; Carvalho, Agostinho; Cunha, Cristina; Costa, Sandra. "c-Met deletion aggravates invasive pulmonary aspergillosis by modulating the antifungal effector functions of immune cells". Paper presented in XLVII Annual Meeting of the Portuguese Society for Immunology, 2022.
  4. Vieira, Joana; Sónia Pires-Celeiro; Granja, Sara; Barbosa-Matos, Catarina; H Ko, Young ; Preto, Ana; Odília Queirós; Casal, Margarida; Baltazar, Fátima. "Targeting glycolytic metabolism as a therapeutic strategy for Acute Myeloid Leukemia". Paper presented in EACR 2021 Virtual Congress, 2021.
  5. Joana Pereira-Vieira; Sónia Pires-Celeiro; Sara Granja; Catarina Barbosa-Matos; Young H Ko; Ana Preto; Odília Queirós; Margarida Casal; Fátima Baltazar. "3-bromopyruvate boosts the effect of chemotherapy in acute myeloid leukaemia by reducing cell antioxidant defence". Paper presented in Cancer Biology: From Basic to Translational Research - Liga Portuguesa Contra o Cancro (Virtual Conference), 2020.
  6. Joana Pereira-Vieira; Sara Granja; Catarina Barbosa-Matos; Young H Ko; Ana Preto; Odília Queirós; Margarida Casal; Fátima Baltazar. "Non-toxic concentrations of 3-bromopyruvate sensitize acute myeloid leukemia (AML) cells to chemotherapy by inducing oxidative stress". Paper presented in EACR-AACR-ASPIC Conference on Tumor Microenvironment, 2020.
  7. Joana Pereira-Vieira; Sara Granja; Catarina Barbosa-Matos; Young H Ko; Ana Preto; Odília Queirós; Margarida Casal; Fátima Baltazar. "3-Bromopyruvate pre-treatment sensitizes MOLM13 and KG-1 cell lines to chemotherapy". Paper presented in 6th International Society of Cancer Metabolism (ISCaM) Annual Meeting - Cancer Metabolic Rewiring: Mapping the Road to Clinical Translation, 2019.
  8. Catarina Barbosa-Matos; Caroline Borges-Pereira; Sofia Libório-Ramos; Egídio Torrado; Massimiliano Mazzone; Sandra Costa. "Induction of c-Met expression in immune cells drives pulmonary fibrosis progression". Paper presented in Champalimaud Research Symposium - Tissue Environment in Health and Disease, 2019.
  9. Julieta Afonso; Ricardo Marques; Catarina Barbosa-Matos; Martin Michaelis; Adhemar Longatto; Lúcio Santos; Jindrich Cinatl Jr; et al. "Cisplatin-resistant urothelial bladder cancer cells undergo metabolic reprogramming.". Paper presented in 26th Porto Cancer Meeting and 5th Joint Meeting Porto-Bordeaux, 2019.
  10. Joana Pereira-Vieira; Sara Granja; Catarina Barbosa-Matos; Young H Ko; Ana Preto; Margarida Casal; Fátima Baltazar. "3-Bromopyruvate sensitizes Acute Myeloid Leukemia cell lines to chemotherapy". Paper presented in 26th Porto Cancer Meeting - The Cancer Ecosystem: From Research to Pathology and Treatment, 2019.
  11. Catarina Barbosa-Matos; Caroline Borges-Pereira; Sofia Libório-Ramos; Egídio Torrado; Massimiliano Mazzone; Sandra Costa. "c-Met deletion attenuates lung fibrosis by modulation of immune cells recruitment". Paper presented in XLIV Annual Meeting of the Portuguese Society of Immunology, 2018.
  12. Caroline Borges-Pereira; Sofia Libório-Ramos; Catarina Barbosa-Matos; Cristina Ribeiro-Freitas; Filipa Morais-Santos; Cláudia Antunes; Adhemar Longatto-Filho; et al. "Fetal lung tissue macrophages deficiency modulates apoptosis and alveolar epithelial differentiation during early stages of alveologenesis". Paper presented in XLIII Annual Meeting of the Portuguese Society of Immunology, 2017.
  13. Caroline Borges-Pereira; Sofia Libório-Ramos; Catarina Barbosa-Matos; Cristina Ribeiro-Freitas; Filipa Morais-Santos; Cláudia Antunes; Adhemar Longatto-Filho; et al. "Tissue macrophages modulate alveolar epithelial and myofibroblast differentiation during fetal lung sacculation". Paper presented in ASCB/EMBO 2017 Meeting, 2017.
Journal article
  1. Catarina Barbosa-Matos; Caroline Borges-Pereira; Sofia Libório-Ramos; Raquel Fernandes; Marcela Oliveira; Ana Mendes-Frias; Ricardo Silvestre; et al. "Deregulated immune cell recruitment orchestrated by c-MET impairs pulmonary inflammation and fibrosis". Respiratory Research (2024): https://doi.org/10.1186/s12931-024-02884-1.
    Published • 10.1186/s12931-024-02884-1
  2. Afonso, Julieta; Catarina Barbosa-Matos; Silvestre, Ricardo; Pereira-Vieira, Joana; Gonçalves, Samuel Martins; Mendes-Alves, Camille; Parpot, Pier; et al. "Cisplatin-Resistant Urothelial Bladder Cancer Cells Undergo Metabolic Reprogramming beyond the Warburg Effect". Cancers 16 7 (2024): 1418. http://dx.doi.org/10.3390/cancers16071418.
    Published • 10.3390/cancers16071418
  3. Pereira-Vieira, Joana; Weber, Daniela D.; Silva, Sâmia; Catarina Barbosa-Matos; Granja, Sara; Reis, Rui Manuel; Queirós, Odília; et al. "Glucose Metabolism as a Potential Therapeutic Target in Cytarabine-Resistant Acute Myeloid Leukemia". Pharmaceutics 16 4 (2024): 442. http://dx.doi.org/10.3390/pharmaceutics16040442.
    Published • 10.3390/pharmaceutics16040442
  4. Raquel Fernandes; Catarina Barbosa-Matos; Caroline Borges-Pereira; Ana Luísa Rodrigues Toste de Carvalho; Sandra Costa. "Glycogen Synthase Kinase-3 Inhibition by CHIR99021 Promotes Alveolar Epithelial Cell Proliferation and Lung Regeneration in the Lipopolysaccharide-Induced Acute Lung Injury Mouse Model". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25021279.
    Published • 10.3390/ijms25021279
  5. Sofia Libório-Ramos; Catarina Barbosa-Matos; Raquel Fernandes; Caroline Borges-Pereira; Sandra Costa. "Interstitial Macrophages Lead Early Stages of Bleomycin-Induced Lung Fibrosis and Induce Fibroblasts Activation". Cells (2023): https://doi.org/10.3390/cells12030402.
    Published • 10.3390/cells12030402
  6. Sara da Silva-Ferreira; Cláudio Duarte-Oliveira; Daniela Antunes; Catarina Barbosa-Matos; Ana Mendes-Frias; Egídio Torrado; Sandra Costa; et al. "Hypoxia inducible-factor 1 alpha regulates neutrophil recruitment during fungal-elicited granulomatous inflammation". Frontiers in Cellular and Infection Microbiology 12 (2022): http://dx.doi.org/10.3389/fcimb.2022.1005839.
    Published • 10.3389/fcimb.2022.1005839
  7. Oliveira, Rafaela Dias; Celeiro, Sónia Pires; Catarina Barbosa-Matos; Freitas, Ana Sofia; Cardoso, Susana M.; Viana-Pereira, Marta; Almeida-Aguiar, Cristina; Baltazar, Fátima. "Portuguese Propolis Antitumoral Activity in Melanoma Involves ROS Production and Induction of Apoptosis". Molecules 27 11 (2022): 3533. http://dx.doi.org/10.3390/molecules27113533.
    Published • 10.3390/molecules27113533
  8. Brito, Pedro S.; Costa, Jorge V.; Barbosa-Matos, Catarina; Costa, Sandra M.; Correia-Pinto, Jorge; Silva, Rufino M.. "Association of serum vasogenic and proinflammatory factors with clinical response to anti-vascular endothelial growth factor for diabetic macular edema". Retina 41 2 (2020): 345-354. http://dx.doi.org/10.1097/iae.0000000000002852.
    Published • 10.1097/iae.0000000000002852
  9. Gonçalves, Samuel M.; Duarte-Oliveira, Cláudio; Campos, Cláudia F.; Aimanianda, Vishukumar; ter Horst, Rob; Leite, Luis; Mercier, Toine; et al. "Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-16120-z.
    Published • 10.1038/s41467-020-16120-z
  10. Ferreira, Débora; Silva, Ana P.; Nobrega, Franklin L.; Martins, Ivone M.; Barbosa-Matos, Catarina; Granja, Sara; Martins, Sandra F.; Baltazar, Fátima; Rodrigues, Ligia R.. "Rational Identification of a Colorectal Cancer Targeting Peptide through Phage Display". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-40562-1.
    Published • 10.1038/s41598-019-40562-1
Thesis / Dissertation
  1. Matos, Ana. "Lung fibrosis regulation by c-Met-expressing immune cells". Master, Universidade do Minho Escola de Medicina, 2018.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/05 Regulation of pulmonary fibrosis by hepatocyte growth factor receptor signaling EMBO/FEBS 2019 Meeting - Molecular mechanisms of tissue injury, repair and fibrosis
(Spetses Island, Greece)
2018/11 c-Met inhibition attenuates lung fibrosis by modulation of inflammatory recruitment 34th Pneumonology Congress
Sociedade Portuguesa de Pneumologia (Algarve, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/06 - 2023/09 Postgraduate Students Retreat - MSc or PhD, grab your future (2023/09 - 2024/09)
Meeting (Member of the Organising Committee)
 Universidade do Minho Escola de Medicina, Portugal
2014/04 - 2014/04 V Jornadas de Bioquímica - Ciência dentro de Portas (2013/09 - 2014/04)
Meeting (Member of the Organising Committee)
 Universidade do Minho, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/03/11 - 2021/03/12 Repair and regeneration in chronic lung disease and lung cancer, 19th Lung Science Conference (Virtual)
Conference
European Respiratory Society, Switzerland

Association member

Society Organization name Role
2016 - 2016 Núcleo de estudantes de Bioquímica da Universidade do Minho (NEBQUM) Chairman of the Board of the Shareholder's Meeting

Committee member

Activity description
Role 		Institution / Organization
2021 - 2024 Advanced years PhD Students Subdelegate, PhD program in Health Sciences
Member
 Universidade do Minho Escola de Medicina, Portugal
2021 - 2024 Representative Student in Pedagogic Council
Member
 Universidade do Minho Escola de Medicina, Portugal
2019/10 - 2021 1st year PhD Students Delegate, PhD program in Health Sciences
Member
 Universidade do Minho Escola de Medicina, Portugal
2017 - 2018 2nd year Class Delegate, Master in Health Sciences
Member
 Universidade do Minho Escola de Medicina, Portugal
2016 - 2017 1st year Class Delegate, Master in Health Sciences
Member
 Universidade do Minho Escola de Medicina, Portugal

Mentoring / Tutoring

Topic Student name
2023 - Current Master Thesis - Master in Clinical Laboratory Biology Ana Beatriz Machado
2020/11 - 2021/05 Laboratory Rotation - Master in Health Sciences Ana Rita Fernandes
2018/04 - 2018/06 Bachelor's Project - Biochemistry Raquel Alexandra Gomes Fernandes
2018/04 - 2018/06 Bachelor's Project - Biochemistry João Vítor Lemos Afonso
2017/10 - 2018/04 Laboratory Rotation - Master in Health Sciences Bruna Alexandra Vale Araújo
2017/07 - 2017/09 Summer Laboratory Rotation - Medicine Mara Areias Macieira
Distinctions

Award

2023 Best poster in Fungal update: Mycology Conference 2023
2020 Best poster in Cancer Biology: From Basic To Translational Research 2020 (Virtual Conference)
Liga Portuguesa Contra o Cancro, Portugal
2013 Scholastic excellence award
2013 Merit and value award