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Raquel T. Lima has over 2 decades in Cancer Research, focusing in Cancer Translational Biomarkers and Targeted Therapies. Currently, she integrates the Bioinformatics and Molecular Analysis teams at IPATIMUP Diagnostics, utilizing NGS technology to identify genetic variants, biomarkers, and signatures in cancer patients to aid precision oncology. Raquel holds a degree in Biochemistry (2000; FCUP), MSc in Molecular Oncology (2005; FMUP) and PhD in Pharmaceutical Sciences (2010; FFUP). Her research has contributed to the identification and validation of biological targets to overcome cancer drug resistance and to the identification of novel hit small molecules for anticancer therapy. Raquel published 64 papers and 24 abstracts in peer-reviewed journals (including Diagnostics, Cancers, IJMS, Autophagy, Annals Oncol., Sci reports, BBA, Cancer letters, Cancer res, Blood, Eur J cancer); 2 book chapters and has over 90 communications in national and international meetings; having an h-index 24 and over 5000 citations. She acted guest editor in Pharmaceuticals special issues- #Targeting Thyroid Cancer: From Biology to Therapeutic Strategies" and "Cancer Translational Biomarkers and Targeted therapies" and as review editor in “Fontiers in Molecular Biosciences (section "Molecular Diagnostics and Therapeutics"). Raquel was leader of a successfully concluded FCT funded project (PTDC/MEC-ONC/31520/2017) aiming at the validation of LRP1B endocytic receptor as predictive marker of response to liposomal drugs. Her scientific career includes active participation in several multidisciplinary/inter-institutional projects; important collaborations with leading experts and integration in networks/associations at national and international levels. Raquel was Managing Committee Substitute member (FTC portugal) in European Network of Multidisciplinary Research and Translation of Autophagy Knowledge Transautophagy-cost action 15138. She has evaluated projects for Eu-funded cost open calls; reviewed for international peer-reviewed journals, and also participated in 10 academic juris (6 as main examiner). Raquel is currently the main supervisor of 1 PhD student. In the recent past she successfully (co)supervised to completion 2 PhD students , 8 MSc students (5 as main supervisor) and tutored several students in the lab. Raquel is also an experienced teacher at under/post-graduate level, being an Affiliated Professor in Faculty of Medicine-UP and Invited Adjunct Professor in Santa Maria School of Health, Porto. Raquel actively contributes to science dissemination: she supervised high-schoolers first contact to lab sciences (Ciência viva; Escola das ciências da vida e saúde-UP) and participates in science fairs (Mostra-UP).
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Identification

Personal identification

Full name
Raquel Maria Torres Lima

Citation names

  • Lima, Raquel
  • Raquel T. Lima
  • Lima, RT

Author identifiers

Ciência ID
FC1C-BA48-38A6
ORCID iD
0000-0002-5838-9659
Scopus Author Id
7103094614

Email addresses

  • rlima@ipatimup.pt (Professional)
Affiliation

Science

Category
Host institution 		Employer
2018/07/15 - 2023/06/30 Researcher (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
(...)
2016/04/01 - 2018/07/15 Postdoc (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
(...)
2017/07/10 - 2017/07/27 Visiting Researcher (Research) Instituto Nacional de Câncer, Brazil
2011/05/01 - 2016/04/30 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
1999/09/01 - 2000/10/31 Research Trainee (Research) Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2016/09 - Current Invited Adjunct Teacher (Polytechnic Teacher) Escola Superior de Enfermagem de Santa Maria, Portugal
2015 - Current Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
2013 - Current Invited Adjunct Teacher (Polytechnic Teacher) Escola Superior de Saúde de Santa Maria, Portugal
2001/09 - 2016/02/29 Invited Adjunct Teacher (Polytechnic Teacher) Escola Superior de Enfermagem de Santa Maria, Portugal
2015 - 2016 Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
2013 - 2016 Invited Adjunct Teacher (Polytechnic Teacher) Escola Superior de Enfermagem de Santa Maria, Portugal

Others

Category
Host institution 		Employer
2023/07/01 - Current PhD Research Techician Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2023/06/01 - Current Scientific Collaborator - Cancer Signalling and Metabolism Group Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/01/09 - 2013/05/08 Maternity Leave Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
(...)
2006/05/01 - 2010/12/21 PhD student with PhD grant Fundação para a Ciência e a Tecnologia, Portugal
2009/10/30 - 2010/02/26 Maternity Leave Fundação para a Ciência e a Tecnologia, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal
(...)
2003/04/01 - 2005/09/30 MSc student in Molecular Oncology Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2000/10/01 - 2001/03/31 Lab Technician Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Projects

Contract

Designation Funders
2022/01/15 - Current Within project NORTE-01-0145-FEDER-072678 - Consórcio PORTO.CCC – Porto.Comprehensive Cancer Center
NORTE-01-0145-FEDER-072678 P.CCC
Researcher
2018/07/15 - 2022/01/14 Predicting patients response to liposomal anticancer drugs: focusing on LRP1B endocytic activity-PTDC/MEC-ONC/31520/2017
PTDC/MEC-ONC/31520/2017
PTDC/MEC-ONC/31520/2017
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2017/01/01 - 2021/06/30 Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy
SAICTPAC/0022/2015
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal

Fundação Calouste Gulbenkian, Portugal

Universidade de Coimbra, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Institute for Research and Innovation in Health Sciences
UID/BIM/04293/2019
LA/P/0070/2020
10.54499/LA/P/0070/2020
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/04/01 - 2014/09/30 Estudos funcionais, moleculares e farmacológicos das proteínas da família p53: da levedura às células humanas
PTDC/SAU-FAR/110848/2009
Universidade da Madeira, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/06/01 - 2013/11/30 Molecular and nanotechnology-based approaches to improve the antitumor activity of small molecules / Abordagens Molecular e Nanotecnológica para a melhoria da actividade antitumoral de pequenas moléculas
PTDC/SAU-FCF/100930/2008
Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Cooperativa de Ensino Superior Politécnico e Universitário CRL, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 3 - 2011-2012
PEst-C/SAU/LA0003/2011
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Seca, H.; Lima, R.T.; Vasconcelos, M.H.. "MicroRNAs in cancer drug resistance and drug sensitivity". In MicroRNAs: Key Regulators of Oncogenesis. Switzerland: Springer International Publishing, 2014.
    10.1007/978-3-319-03725-7_11
  2. Raquel T. Lima. "EBV-associated cancers: Strategies for targeting the virus". In Microbial pathogens and strategies for combating them: science, technology and education, 1608-1618. Formatex, 2013.
    Published
Conference abstract
  1. Teixeira, Elisabete; Cláudia Fernandes; Gaspar, Tiago Bordeira; Ferreira, Marta; Raquel T. Lima; Canberk, Sule; Hugo Prazeres; et al. "Genetics of familial non-medullary thyroid carcinoma - investigation of two families¿". Paper presented in 45th Annual Meeting of the European Thyroid Association ETA 2023, Milan, 2023.
    Published
  2. Gimba, Etel; Lemos, Ana; Ferreira, Luciana; Lima, Raquel; Tavares, Catarina; Batista, Rui; Soares, Paula. "Osteopontin-a enhances cytoskeleton remodeling and activates intermediate epithelial mesenchymal properties in c643 thryoid cancer cells". Paper presented in International Symposium on Immunobiological, 2021.
    Published • 10.35259/isi.2021_46610
  3. Lima, Raquel; Sousa, Diana; Seca, H.; Palmeira, A.; Paiva, A.; Gomes, A.; Lopes-Rodrigues, V; et al. "A new small molecule with antitumour and chemosensitizing potential as P-gp inhibitor". Paper presented in Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells COST Action CM1106 1st Working Group Meeting, 2013.
Conference poster
  1. Sousa, Diana; Rebelo, Rita; Raquel T. Lima; Xavier, Cristina PR; Vasconcelos, M. Helena. ""Drug sequestration by Extracellular Vesicles: preliminary evidence for a role of P-glycoprotein in this process". Poster communication and speed talk presented by Rita Rebelo at the International Online Symposium on "New Therapeutic Tools Against Preclinical Models of Multidrug Resistant Tumors". Online event. November 4th, 2020.". 2020.
  2. Sousa, Isabel; Cunha, A. I.; Gimba, Etel R. P.; Portugal, Raquel; Prazeres, Hugo; Lopes, José Manuel; Soares, Paula; Raquel T. Lima. "LRP1B as a predictor of response to liposomal doxorubicin and a possible prognostic marker in ovarian cancer". Paper presented in EACR-AACR-ASPIC conference on Tumour Microenvironment (TME), 2020.
  3. Príncipe, A.; Pestana, Ana; Soares, Paula; Raquel T. Lima. "Generation of a LRP1B-Knockout Glioblastoma Cell Line Model via CRISPR/Cas9". Paper presented in IJUP2020, 2020.
  4. Sousa, Diana; Matthiesen, Rune; Raquel T. Lima; Vasconcelos, M. Helena. "Deep sequencing analysis shows distinct transcripts in tumor multidrug resistant cells and their extracellular vesicles when compared with their drug-sensitive counterparts". Paper presented in I3S annual meeting, 2019.
  5. Cunha, Ana Isabel; Sousa, Isabel; Portugal, Raquel; Gimba, Etel R. P.; Prazeres, Hugo; Soares, Paula; Raquel T. Lima. "LRP1B expression in ovarian cancer tissues: An immunohistochemical approach". Paper presented in i3S annual meeting, 2019.
  6. Pestana, A.; Sousa, A.; Vinagre, J.; Correia, M.; Batista, R.; Raquel T. Lima; Tavares, C.; et al. "TERT function in thyroid cancer: beyond immortalization". Paper presented in i3s annual meeting, 2019.
  7. Barrambana, Sara; Correia, Marcelo; Lima, Ana Rita; Pestana, A.; Raquel T. Lima; Máximo, Valdemar. "Mitochondrial Dynamics in Thyroid Cancer: Unravelling the Role of DRP1". Paper presented in 11th Symposium on Metabolism, 2019.
  8. Sousa, Diana; Raquel T. Lima; Lopes-Rodrigues, Vanessa; royo, F.; Falcon-Perez, J.M.; Vasconcelos, M. Helena. "Understanding mechanism of release and internalization of extracellular vesicles by multidrug resistant and sensitive cancer cells”". Paper presented in I3S Annual Meeting 2018, 2018.
  9. Saraiva, Inês de Andrade Matos Gonçalves; Prazeres, Hugo; Sousa, Isabel; Soares, Paula; Raquel T. Lima. "Studying the role of LRP1B in the response of cancer cells to liposomal doxorubicin". Paper presented in I3S Annual Meeting 2018, 2018.
  10. Saraiva, Inês de Andrade Matos Gonçalves; Sousa, Isabel; Prazeres, Hugo; Soares, Paula; Raquel T. Lima. "LRP1B endocytic activity: possible implications in the uptake of liposomal anticancer drugs". Paper presented in SMETS2- 2nd Small Meeting on Endocytic Trafficking and Signaling, 2018.
  11. Ferreira, Luciana B.; Lima, Raquel T.; Bastos, Ana Clara Santos da Fonseca; Silva, Andreia Machado; Tavares, Catarina; Pestana, Ana; Rios, Elisabete; et al. "Abstract 180: OPNa variant expression is associated with matrix mineralization in thyroid cancer cell lines". Paper presented in AACR Annual Meeting 2018, 2018.
    10.1158/1538-7445.am2018-180
  12. Silva, Patrícia M. A.; Diogo, V.; Teixeira, J.; Ribeiro, Nilza; Raquel T. Lima; Vasconcelos, M. Helena; Florindo, C.; Tavares, A. A.; Bousbaa, Hassan. "Targeting Spindly as Antimitotic Strategy to Induce Cancer Cell Death". Paper presented in 2nd ASPIC International Congress, 2016.
  13. Cidade, Honorina; Pereira, D.; Raquel T. Lima; Palmeira, Andreia; Seca, Hugo; Soares, J.; Gomes, Sara; et al. "New Inhibitors of p53-MDM2 Interaction With a Chalcone Scaffold". Paper presented in 11º Encontro Nacional de Química Orgânica e 4º Encontro de Química Terapêutica, 2015.
  14. Lopes-Rodrigues, Vanessa; Oliveira, A.; Correia-da-Silva, Marta; Pinto, Madalena M. M; Raquel T. Lima; Vasconcelos, M. Helena. "A new curcumin derivative with more potent antitumor and anti-P-glycoprotein activity than curcumin". Paper presented in 11º Encontro Nacional de Química Orgânica e 4º Encontro de Química Terapêutica, 2015.
  15. Sousa, Diana; Lopes-Rodrigues, Vanessa; Lima, Raquel T.; Vasconcelos, M. Helena. "Transfer of drug-resistance by Extracellular Vesicles shed by tumor cells". Paper presented in First Iberian meeting on Extracellular vesicles, 2015.
  16. Lopes-Rodrigues, Vanessa; Di Luca, Alessio; Sousa, Diana; Seca, Hugo; Meleady, Paula; Henry, Michael; Raquel T. Lima; O'Connor, Robert; Vasconcelos, M. Helena. "Extracellular vesicles from multidrug resistant cells different in size, number and protein signature from their drug-sensitive counterparts". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014.
  17. Coutinho, I.; Lopes-Rodrigues, Vanessa; Perro-Neves, Marta; Raquel T. Lima; Pereira, Clara; Kijjoa, Anake; Pinto, Madalena M. M; Cidade, Honorina; Vasconcelos, M. Helena. "Identification of potent small-molecule activators of caspase-7 through yeast target-based screening assays". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014.
  18. Bizarro, Ana Sofia; Ferreira, Isabel C.F.R.; Sokovic, Marina; Van Griensven, Leo J.L.D.; Sousa, Diana; Vasconcelos, M. Helena; Bizarro, Ana; Ferreira, Isabel C.F.R.; Raquel T. Lima. "Cordyceps militaris (L.) Link fruiting body reduces NCI-H460 cellular viability through a mechanism involving p53 and p21". Paper presented in XX Encontro Luso- Galego de Química, 2014.
  19. Lima, Maria João; Sousa, Diana; Raquel T. Lima; Carvalho, A. M.; Ferreira, Isabel C.F.R.; Vasconcelos, M. Helena. "Flower extracts of Filipendula ulmaria (L.) Maxim inhibit the cell growth of human tumour cell lines". Paper presented in XX Encontro Luso- Galego de Química, 2014.
  20. Reis, Filipa S.; Raquel T. Lima; Morales, Patricia; Ferreira, Isabel C.F.R.; Vasconcelos, M. Helena; Lima, Raquel T.; Ferreira, Isabel C.F.R.. "Studying Ganoderma lucidum as a source of molecular inducers of autophagy". Paper presented in I3S Scientific Retreat 2014, 2014.
  21. Lopes-Rodrigues, Vanessa; Di Luca, Alessio; Sousa, Diana; Seca, Hugo; Meleady, Paula; Henry, Michael; Raquel T. Lima; O'Connor, Robert; Vasconcelos, M. Helena. "Extracellular vesicles shed by multidrug resistant cells are bigger than their sensitive counterparts and have a cargo with a specific signature of proteins involved in their biogenesis". Paper presented in I3S Scientific Retreat 2014, 2014.
  22. Seca, Hugo; Raquel T. Lima; Almeida, Gabriela M.; Sobrinho-Simões, M. A.; Bergantim, Rui; Guimarães, José E.; Vasconcelos, Helena M.. "miR-128 increases DNA damage in acute myeloid leukemia cells". Paper presented in I3S Scientific Retreat 2014, 2014.
  23. Raquel T. Lima; Sousa, Diana; Mendes, Nuno; Matthiesen, Rune; Gomes, Ana Sara; Pinto, Madalena M. M; Sousa, Emília; Vasconcelos, M. Helena. "TXA1.HCl induces autophagy in NCI-H460 cells and reduces the growth of these lung cancer cells xenografted in nude mice". Paper presented in i3S retreat 2014, 2014.
  24. Raquel T. Lima; Pereira, Daniela; Seca, Hugo; soares, joana; Gomes, Sara; Raimundo, L.; Maciel, C.; et al. "Synthesis, screening and evaluation of the activity of new p53 activators in human tumour cell lines". Paper presented in I3S Scientific Retreat 2014, 2014.
  25. Reis, Filipa S.; Raquel T. Lima; Morales, Patricia; Ferreira, Isabel C.F.R.; Vasconcelos, M. Helena; Lima, Raquel T.; Ferreira, Isabel C.F.R.. "A cold methanolic extract of Ganoderma lucidum (Curtis) P. Karst induces autophagy in a gastric cancer cell line". Paper presented in 62nd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research – GA2014, University of Minho, Guimarães, 2014.
  26. Raquel T. Lima. "Investigating the cell growth inhibitory effect of flower extracts of Sambucus nigra L. in human tumor cell lines". Paper presented in IJUP’14- 7º Encontro de Jovens Investgadores da Universidade do Porto, 2014.
  27. Raquel T. Lima. "Flower extracts of Filipendula ulmaria (L.) Maxim inhibit the proliferation of human tumor cell lines". Paper presented in IJUP’14- 7º Encontro de Jovens InvestIgadores da Universidade do Porto, 2014.
  28. Dias, Ana Sofia Couto Bizarro de Castro; Ferreira, Isabel C.F.R.; Sokovic, Marina; Van Griensven, Leo J.L.D.; Vasconcelos, M. Helena; Raquel T. Lima. "Effect of Cordyceps militaris methanolic extract in NCI-H460 tumor cells". Paper presented in IJUP’14- 7º Encontro de Jovens InvestIgadores da Universidade do Porto, 2014.
  29. Raquel T. Lima. "miR-128 induces DNA damage and sensitizes AML cells to etoposide and doxorubicin". Paper presented in Reunião Anual da Sociedade Portuguesa de Hematologia, 2013.
  30. Hugo Seca; Raquel T. Lima; Gabriela M. Almeida; Vanessa Lopes-Rodrigues; José Eduardo Guimarães; M. Helena Vasconcelos. "miR-21 downregulation chemosensitizes K562 and KYO-1 Chronic Myeloid Leukemia cells via induction of autophagy". Paper presented in XXII Porto Cancer Meeting, 2013.
  31. Hugo Seca; Gabriela M. Almeida; Raquel T. Lima; Manuel A. Sobrinho-Simões; José Eduardo Guimarães; M. Helena Vasconcelos. "miR-128 increases cellular DNA damage and sensitizes Acute Myeloid Leukemia cells to chemotherapeutic drugs". Paper presented in XXII Porto Cancer Meeting, 2013.
  32. Gomes, Ana Sara; Oliveira, Tiago; Sousa, D.; Lima, Raquel; Salvador, J. A. R.; Vasconcelos, Helena; Pinto, Madalena; Sousa, Emília. "Studies of the possible oxidative metabolism of a promising antitumor compound". Paper presented in XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting "Translational Research in Cancer ¿ Bringing Basic Science and Pathology to Clinical Oncology", 2013.
  33. A. M. Paiva; R. A. Pinto; M. Teixeira; C.M. Barbosa; Raquel T. Lima; M. Helena Vasconcelos; Madalena M. M. Pinto. "Incorporation of a xanthone into nanoparticles increases its tumour cell growth inhibitory effect". Paper presented in 3º Encontro Nacional de Química Terapeutica, 2012.
  34. Raquel T. Lima; Diana Sousa; K. Choosang; P. Pakkong; Ana Paiva; Andreia Palmeira; Hugo Seca; F. Cerqueira; M. Pedro. "Identification of a potent xanthone which induces cell death in a melanoma cell line model"". Paper presented in 3º Encontro Nacional de Química Terapeutica, 2012.
  35. Raquel T. Lima; Diana Sousa; K. Choosang; P. Pakkong; Ana Paiva; Andreia Palmeira; Hugo Seca; et al. "Identification of a potent xanthone which induces cell death in a melanoma cell line model". Paper presented in 3º Encontro Nacional de Química Terapeutica, 2012.
  36. C. M. G. Azevedo; C. M. M. Afonso; M. Helena Vasconcelos; Diana Sousa; Raquel T. Lima; Madalena M. M. Pinto. "Synthesis of fused 2,2-dimethyl-3,4-dihydrobenzopyran xanthones and evaluation of their growth inhibitory effect on four human tumour cell lines". Paper presented in 3º Encontro Nacional de Química Terapeutica, 2012.
  37. I. Coutinho; Vanessa Lopes-Rodrigues; Marta Perro-Neves; Raquel T. Lima; C. Pereira; Anake Kijjoa; Madalena M. M. Pinto; et al. "Discovery of potent small-molecule activators of caspase-7 with promising anticancer activity". Paper presented in 3º Encontro Nacional de Química Terapeutica, 2012.
  38. Hugo Seca; Raquel T. Lima; Gabriela M. Almeida; Manuel A. Sobrinho-Simões; José Eduardo Guimarães; M. Helena Vasconcelos. "AntimiRs and miR-mimetics in the identification of miR function". Paper presented in One Day Symposium sponsored by EACR Darwinian evolution and clonal heterogeneity in human cancer: biological and clinical implications,, 2012.
  39. Vanessa Lopes-Rodrigues; I. Coutinho; Marta Perro-Neves; Raquel T. Lima; Clara Pereira; Anake Kijjoa; Madalena M. M. Pinto; M. Helena Vasconcelos; Lucília Saraiva. "Flavonoids targeting caspase-7: priming tumour cells for death". Paper presented in BIOTECHNOLOGY IN ACTION: Stem Cells & Tissue Engineering, Biopharmaceutical Production and Cancer Biomarkers, Dublin City University,, 2012.
  40. Raquel T. Lima; G. Barron; J. A. Grabowska; G. Bermano; M. Helena Vasconcelos; P. K. T. Lin. "BNIPDaCHM: a bisnaphthalimidopropyl derivative which targets SIRT2 and affects NCI-H460 lung cancer cells viability". Paper presented in 3S Scientific Retreat - IBMC, INEB, IPATIMUP,, 2012.
  41. A. M. Paiva; Rita A. Pinto; M. Teixeira; C. M. Barbosa; Raquel T. Lima; M. Helena Vasconcelos; Madalena M. M. Pinto; Emília Sousa. "Improved cytotoxic effect of a bioactive xanthone incorporated in polymeric nanoparticles". Paper presented in I3S Scientific Retreat - IBMC, INEB, IPATIMUP, 2012.
  42. Hugo Seca; Raquel T. Lima; Gabriela M. Almeida; Vanessa Lopes-Rodrigues; José E. Guimarães; M. Helena Vasconcelos. "Sensitizing chronic myeloid leukaemia cells to the effects of cytotoxic drugs with antimiRs for miR-21". Paper presented in I3S Scientific Retreat - IBMC, INEB, IPATIMUP, 2012.
  43. I. Coutinho; Vanessa Lopes-Rodrigues; Marta Perro-Neves; Raquel T. Lima; Clara Pereira; Anake Kijjoa; Madalena M. M. Pinto; et al. "Flavonoids priming tumour cells for death". Paper presented in I3S Scientific Retreat - IBMC, INEB, IPATIMUP, 2012.
  44. Hugo Seca; Raquel T. Lima; Gabriela M. Almeida; Vanessa Lopes-Rodrigues; José Eduardo Guimarães; M. Helena Vasconcelos. "Autophagy induction by downregulation of miR-21 expression". Paper presented in XXI Porto Cancer Meeting, 2012.
  45. B. Macedo; Ana Paula Almeida; Sara Cravo; T. Dethoup; Raquel T. Lima; M. Helena Vasconcelos; Madalena M. M. Pinto. "HPLC analysis from the crude extract and metabolites isolated from the marine fungus Eutorium cristatum". Paper presented in IJUP12, 2012.
  46. J. A. Grabowska; Raquel T. Lima; M. Helena Vasconcelos; P. K. T. Lin. "Study of the effect of a bisnaphthalimidopropyl polyamine derivative in a non-small lung cancer cell line". Paper presented in Workshop-Antiparasitic and Antitumour drugs,, 2011.
  47. Hugo Seca; Raquel T. Lima; Andreia Palmeira; F. Castro; Marta Correia-da-Silva; Miguel Xavier Fernandes; De São José Nascimento, M.; et al. "Searching for small molecules against latent EBV infection: an in silico approach confirmed by in vitro activity". Paper presented in I3S Scientific Retreat - IBMC, INEB, IPATIMUP, 2011.
  48. Marta Perro-Neves; J. Flor; Honorina Cidade; Madalena M. M. Pinto; A. M. S. Silva; Raquel T. Lima; M. Helena Vasconcelos; De São José Nascimento, M.. "Synthetic prenylated flavonoids as interesting apoptosis inducers". Paper presented in I3S Scientific Retreat - IBMC, INEB, IPATIMUP, 2011.
  49. Pedro M. Borralho; A. E. S. Simões; S. E. Gomes; Raquel T. Lima; T. Carvalho; M. Helena Vasconcelos; Cecília M. P. Rodrigues. "miR-143 overexpression reduces the growth of xenograft Tumors from colon carcinoma cells, increasing tumor cell apoptosis and decreasing proliferation". Paper presented in XX Porto Cancer Meeting, IPATIMUP, Porto, 2011.
  50. Hugo Seca; Gabriela M. Almeida; Raquel T. Lima; Manuel A. Sobrinho-Simões; José Eduardo Guimarães; M. Helena Vasconcelos. "The role of miR-128-1, miR-21a and miR-181a in the response of an Acute Myeloid Leukemia cell line to chemotherapeutic drugs". Paper presented in XX Porto Cancer Meeting, 2011.
  51. Marta Perro-Neves; J. Flor; Honorina Cidade; Madalena M. M. Pinto; A. M. S. Silva; I. Coutinho; Lucilia Saraiva; et al. "Synthesis of novel prenylated derivatives of natural occuring flavonoids: study of their effect on cell growth, cell cycle profile and apoptosis". Paper presented in XX Porto Cancer Meeting, 2011.
  52. Andreia Palmeira; R. Castanheira; M. Paiva; Emília Sousa; Hugo Seca; Gabriela M. Almeida; Raquel T. Lima; et al. "Prenylated xanthones with antiproliferative and apoptotic effects in leukaemia cell lines". Paper presented in XX Porto Cancer Meeting, 2011.
  53. Raquel T. Lima; Hugo Seca; Paula Soares; De São José Nascimento, M.; M. Helena Vasconcelos. "EBV and Bcl-xL: a connection relevant for drug response in a Burkitt lymphoma cell line". Paper presented in XX Porto Cancer Meeting, IPATIMUP, 2011.
  54. Marta Perro-Neves; J. Flor; A. C. Carvalho; Madalena M. M. Pinto; Honorina Cidade; Raquel T. Lima; M. Helena Vasconcelos; I. Coutinho; Lucilia Saraiva. "Synthesis of flavonoids with potential antitumor activity". Paper presented in IJUP2011, 2011.
  55. A. Sá; D. Costa; Gabriela M. Almeida; Filipe Santos-Silva; Raquel T. Lima; R. Pereira; M. Teixeira; M. Helena Vasconcelos; C. M. Barbosa. "Polymeric nanoparticles for the siRNAs delivery for antiapoptotic proteins". Paper presented in IJUP11, 2011.
  56. Raquel T. Lima; Hugo Seca; Andreia Palmeira; F. Castro; Marta Correia-da-Silva; Miguel Xavier Fernandes; De São José Nascimento, M.; et al. "Targeting latent EBV infection using small molecules: from in silico screening to in vitro antiviral activity". Paper presented in IJUP11, 2011.
  57. A. Cardoso; B. Macedo; Raquel T. Lima; M. Helena Vasconcelos; Madalena M. M. Pinto; Anake Kijjoa; Ana Paula Almeida. "Evaluation of the growth inhibitory effect on tumour cell lines of the secondary metabolites isolated from the spongeassociated fungi Eurotium cristatum". Paper presented in IJUP2011, 2011.
  58. Raquel T. Lima; Hugo Seca; Paula Soares; De São José Nascimento, M.; M. Helena Vasconcelos. "miR-let-7c is not responsible for Bcl-xL downregulation in the Akata EBV positive Burkitt Lymphoma cell line". Paper presented in XVII National Congress of Biochemistry, 2010.
  59. Raquel T. Lima; Hugo Seca; Andreia Palmeira; Miguel Xavier Fernandes; F. Castro; Marta Correia-da-Silva; De São José Nascimento, M.; et al. "In silico screening and in vitro evidence of antiviral activity of sulfated compounds against latent EBV in a Burkitt Lymphoma cell line". Paper presented in XVII National Congress of Biochemistry, 2010.
  60. Raquel T. Lima; Hugo Seca; Susana Brás; De São José Nascimento, M.; M. Helena Vasconcelos. "Etoposide reactivates EBV to a lesser extent than doxorubicin". Paper presented in Antivirals Congress 2010, Amsterdam, 2010.
  61. Raquel T. Lima; Hugo Seca; Susana Brás; De São José Nascimento, M.; M. Helena Vasconcelos. "Epstein-Barr Virus enhances sensitivity of Burkitt Lymphoma Akata cells to etoposide". Paper presented in Antivirals Congress 2010, Amsterdam, 2010.
  62. Emília Sousa; Andreia Palmeira; Miguel Xavier Fernandes; F. Castro; Marta Correia-da-Silva; E. Costa; De São José Nascimento, M.; et al. "Small molecules targeting EBV: in silico screening and evidence of antiviral activity". 2010.
  63. Ana Paula Almeida; A. A. Q. P. Cardoso; B. Macedo; T. Dethoup; Raquel T. Lima; M. Helena Vasconcelos; Madalena M. M. Pinto; Anake Kijjoa. "Isolation of metabolites from Eurotium cristatum and evaluation of growth inhibition effect on human tumor cell lines". Paper presented in BrazMedChem2010 - The 5th Brazilian Symposium on Medicinal Chemistry,, 2010.
  64. Hugo Seca; Gabriela M. Almeida; Raquel T. Lima; Manuel Sobrinho-Simões; José Eduardo Guimarães; M. Helena Vasconcelos. "MiR-128-1 increases cell death of HL60 cells". Paper presented in Eighth International Conference on Mechanisms of Cell Death and Disease: Advances in therapeutic intervention and drug development, uropean School of Hematology (ESH),, 2010.
  65. Pedro M. Borralho; Rui E. Castro; Raquel T. Lima; M. Helena Vasconcelos; Clifford J. Steer; Cecília M. P. Rodrigues. "MicroRNA-143 regulates colorectal cancer cell growth and apoptosis in vivo and in vitro". Paper presented in Eighth International Conference on Mechanisms of Cell Death and Disease: Advances in therapeutic intervention and drug development, European School of Hematology (ESH),, 2010.
  66. Ana Sara Cordeiro; Andreia Palmeira; Raquel T. Lima; Bruno sarmento; Domingos Ferreira; Emília Sousa; M. Helena Vasconcelos; Madalena M. M. Pinto. "Effect of bioactive xanthones on P-glycoprotein activity and prediction of their intestinal absorption". Paper presented in IV Congresso Científico da APEF – “O Medicamento: Uma molécula, um percurso?”, 2010.
  67. Pedro M. Borralho; S. Gomes; Raquel T. Lima; M. Helena Vasconcelos; Cecília M. P. Rodrigues. "Sobre-expressão do miR-143 em células do cancro do cólon e recto reduz o crescimento tumoral in vivo". Paper presented in XXX Congresso Nacional de Gastroenterologia e Endoscopia Digestiva, 2010.
  68. Andreia Palmeira; Ana Paiva; Emilia Sousa; Hugo Seca; Gabriela M. Almeida; Raquel T. Lima; Miguel Xavier Fernandes; Madalena M. M. Pinto; M. Helena Vasconcelos. "Insights into the in vitro antitumour mechanism of action of XP13, a novel pyroxanthone". Paper presented in I3S Scientific Retreat - IBMC, INEB, IPATIMUP, 2010.
  69. Hugo Seca; Gabriela M. Almeida; Raquel T. Lima; Manuel Sobrinho-Simões; José Eduardo Guimarães; M. Helena Vasconcelos. "The effect of miR128 in an acute myeloid leukemia cell line". Paper presented in I3S Scientific Retreat - IBMC, INEB, IPATIMUP, 2010.
  70. Raquel T. Lima; Hugo Seca; Paula Soares; M. Helena Vasconcelos. "Downregulation of Bcl-xL and apoptosis sensitization is associated with chronic EBV infection in Burkitt's Lymphoma". Paper presented in I3S Scientific Retreat - IBMC, INEB, IPATIMUP, 2010.
  71. Andreia Palmeira; Filipa Castro; Emília Sousa; Raquel T. Lima; Miguel Xavier Fernandes; Madalena M. M. Pinto; M. Helena Vasconcelos. "In silico screening of small molecules targeting EBV". Paper presented in IJUP2010 -3rd meeting of young researchers at UP, 2010.
  72. A. Sá; D. Costa; Gabriela M. Almeida; Filipe Santos-Silva; Raquel T. Lima; R. Pereira; M. Teixeira; M. Helena Vasconcelos; C-M. Barbosa. "Development and characterisation of polymeric nanoparticles containing siRNAs for antiapoptotic proteins". Paper presented in IJUP2010 -3rd Meeting of young researchers at UP, Porto, 2010.
  73. J. Lima; Ana Paiva; Emília Sousa; N. Nazareth; Hugo Seca; Raquel T. Lima; M. Helena Vasconcelos; De São José Nascimento, M.; Madalena M.M. Pinto. "Parallel synthesis of xanthone derivatives for dual action: antitumour activity and P-glycoprotein inhibition". Paper presented in IJUP 09 – 2nd Meeting of young researchers at UP, 2009.
  74. Raquel T. Lima; Hugo Seca; Susana Brás; M. Inês Castro; Dean Fennell; Paula Soares; Nascimento, Maria São José; M. Helena Vasconcelos. "Induction of Epstein - Barr virus (EBV) reactivation in Burkitt Lymphoma cells by anticancer drugs". Paper presented in IJUP 09 – 2nd Meeting of young researchers at UP, 2009.
  75. Raquel T. Lima; Hugo Seca; Dean Fennell; Paula Soares; De São José Nascimento, M.; M. Helena Vasconcelos. "Downregulation of Bcl-xL levels in a latently infected Burkitt Lymphoma cell line". Paper presented in Portuguese-British Meeting on Modulation of Programmed Cell Death and Therapeutic Targets in Cancer and Neurodegenerative Diseases, Porto, Portugal,, 2009.
  76. Andreia Palmeira; Emília Sousa; Ana Paiva; Raquel T. Lima; Hugo Seca; Gabriela M. Almeida; M. Helena Vasconcelos; Madalena M. M. Pinto. "A novel small molecule with dual activity: inhibitor of drug efflux and inducer of apoptosis". Paper presented in Portuguese-British Meeting on Modulation of Programmed Cell Death and Therapeutic Targets in Cancer and Neurodegenerative Diseases,, 2009.
  77. Hugo Seca; Liliana Santos; J. Figueiredo; Raquel T. Lima; José Eduardo Guimarães; M. Helena Vasconcelos. "Targeting XIAP for chemosensitization purposes: Different effect with different cytotoxic drugs". Paper presented in 50th Annual Meeting American Society of Hematology, San Francisco, USA, 2008.
  78. Emília Sousa; E. Costa; Ana Paiva; N. Nazareth; Hugo Seca; J. Pereira; Raquel T. Lima; M. Helena Vasconcelos. "Oxygenated xanthones as models for novel antitumor compounds". Paper presented in 1º Encontro Nacional de Química Terapêutica, Portugal, 2008.
  79. J. Lima; Emília Sousa; N. Nazareth; Hugo Seca; Raquel T. Lima; M. Helena Vasconcelos; De São José Nascimento, M.; Madalena M. M. Pinto. "Parallel synthesis of xanthone derivatives for dual activity: antitumour activity and P-glycoprotein inhibition". Paper presented in 1º Encontro Nacional de Química Terapêutica- Portugak, 2008.
  80. Andreia Palmeira; Ana Paiva; Emília Sousa; Madalena M. M. Pinto; Hugo Seca; Gabriela M. Almeida; Raquel T. Lima; M. Helena Vasconcelos. "Antiproliferative and apoptotic effects induced by a new xanthone derivative in leukaemia cell lines". Paper presented in 16th National Congress of Biochemistry, 2008.
  81. Raquel T. Lima; Hugo Seca; Susana Brás; Maria Inês Castro; Dean Fennell; Paula Soares; De São José Nascimento, M.; M. Helena Vasconcelos. "EBV lytic protein expression following treatment of Akata EBV positive cells with doxorubicin, etoposide or cytarabine". Paper presented in The 33rd International Herpesvirus Worshop,Portugal, Estoril, Portugal,, 2008.
  82. Hugo Seca; Liliana Santos; joana figueiredo; Raquel T. Lima; José Eduardo Guimarães; Clara Sambade; Vasconcelos, M. Helena. "Targeting XIAP as an approach to enhance the effects of chemoterapeutical drugs in K562 leukemia cells". Paper presented in SINAL08- Crosstalk between signaling pathways, Second National Meeting of Signal Transduction, Porto, Portugal, 2008.
  83. Palmeira, A.; Raquel T. Lima; Hugo Seca; M. Helena Vasconcelos; Emília Sousa; Madalena M. M. Pinto. "Flow cytometric detection of P-gp mediated drug efflux: a method for the evaluation of the activity of P-gp inhibitors". Paper presented in IJUP08- First Meeting of Young researchers of U.Porto, 2008.
  84. Raquel T. Lima; Hugo Seca; Maria Inês Castro; Susana Brás; Paula Soares; Nascimento, Maria São José; M. Helena Vasconcelos. "Effects of etoposide, doxorubicin and cytarabine in Burkitt Lymphoma cell lines". Paper presented in IJUP08- First Meeting of Young researchers of U.Porto, 20-22 February 2008, 2008.
  85. Hugo Seca; Liliana Santos; Raquel T. Lima; José Eduardo Guimarães; M. Helena Vasconcelos. "Diminuição estável da expressão genética do XIAP por RNAi aumenta a sensibilidade de células da linha celular K562 à doxorrubicina mas não à citarabina". Paper presented in Reunião Anual da Sociedade Portuguesa de Hematologia, Albufeira, Portugal, 2007.
  86. Raquel T. Lima; Hugo Seca; Susana Brás; Inês Castro; Dean Fennell; Nascimento, Maria São José; M. Helena Vasconcelos. "An EBV Negative Burkitt Lymphoma cell line is less sensitive than its EBV Positive parental cell line to etoposide and doxorubicin but presents similar sensitivity to cytarabine". Paper presented in Reunião Anual da Sociedade Portuguesa de Hematologia, Albufeira, Portugal, 2007.
  87. Raquel T. Lima; Hugo Seca; José Eduardo Guimarães; M. Helena Vasconcelos. "Evaluation of XIAP as a molecular target to increase sensitivity to Imatinib". Paper presented in 48th Annual Meeting of The American Society of Hematology, Orlando, USA, 2006.
  88. joana figueiredo; Raquel T. Lima; Hugo Seca; M. Helena Vasconcelos. "Downregulation of Xiap expression with siRNAs in K562 cells:effects on cellular sensitivity to doxorubicin". Paper presented in XVth National Congress of Biochemistry, 2006.
  89. Hugo Seca; Raquel T. Lima; José Eduardo Guimarães; M. Helena Vasconcelos. "Efeitos da diminuição dos níveis de expressão de P-gp ou de Xiap na resposta ao mesilato de Imatinib na linha celular K562Dox"". Paper presented in Reunião da Sociedade Portuguesa de Hematologia, Viseu, Portugal, 2006.
  90. Raquel T. Lima; José Eduardo Guimarães; M. Helena Vasconcelos. "Overcoming resistance to Imatinib Mesylate in a CML cell line by downregulation of P-gp with siRNAs". Paper presented in The American Society of Hematology 47th Annual Meeting, Atlanta, USA, 2005.
  91. Raquel T. Lima; Luis Miguel Martins; José Eduardo Guimarães; Clara Sambade; M. Helena Vasconcelos. "Chemosensitization effects of XIAP downregulation in K562 cells". Paper presented in XIV Congresso Nacional de Bioquímica, Sociedade Portuguesa de Bioquímica, 2004.
  92. Raquel T. Lima; Daniel J. Braga; M. Helena Vasconcelos. "Optimisation of the transfection of siRNAs for Bcl-2 in a lymphoma cell line". Paper presented in XIV Congresso Nacional de Bioquímica, Sociedade Portuguesa de Bioquímica, Vilamoura, Portugal, 2004.
  93. Raquel T. Lima; Luis Miguel Martins; José Eduardo Guimarães; Clara Sambade; M. Helena Vasconcelos. "RNAi mediated downregulation of bcl-2 and xIAP may have therapeutical potential in human breast adenocarcinoma". Paper presented in ECCO 12- The European Cancer Conference, Federation of European Cancer Societies, 2003.
  94. Raquel T. Lima; Luis Miguel Martins; C. A. Silva; José Eduardo Guimarães; Clara Sambade; M. Helena Vasconcelos. "Downregulation of Bcl-2 by small interfering RNAs sensitizes MCF 7 human breast adenocarcinoma cells to chemotherapy induced death". Paper presented in 1ºCongresso da Sociedade Portuguesa de Ciências Farmacêuticas (SPCF), 2003.
Journal article
  1. Miguel Horta; Paula Soares; Catarina Leite Pereira; Raquel T. Lima. "Emerging Approaches in Glioblastoma Treatment: Modulating the Extracellular Matrix Through Nanotechnology". Pharmaceutics (2025): https://doi.org/10.3390/pharmaceutics17020142.
    10.3390/pharmaceutics17020142
  2. Miguel Horta; Paula Soares; Bruno Sarmento; Catarina Leite Pereira; Raquel T. Lima. "Nanostructured lipid carriers for enhanced batimastat delivery across the blood–brain barrier: an in vitro study for glioblastoma treatment". Drug Delivery and Translational Research (2025): https://doi.org/10.1007/s13346-024-01775-8.
    10.1007/s13346-024-01775-8
  3. Elisabete Teixeira; Cláudia Fernandes; Maria Bungardean; Arnaud Da Cruz Paula; Raquel T. Lima; Rui Batista; João Vinagre; et al. "Investigating USP42 Mutation as Underlying Cause of Familial Non-Medullary Thyroid Carcinoma". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25031522.
    10.3390/ijms25031522
  4. Diana Pádua; Paula Figueira; Mariana Pinto; André Filipe Maia; Joana Peixoto; Raquel T. Lima; António Pombinho; et al. "High-Throughput Drug Screening Revealed That Ciclopirox Olamine Can Engender Gastric Cancer Stem-like Cells". Cancers (2023): https://doi.org/10.3390/cancers15174406.
    10.3390/cancers15174406
  5. Joana Peixoto; Catarina Príncipe; Ana Pestana; Hugo Osório; Marta Teixeira Pinto; Hugo Prazeres; Paula Soares; Raquel T. Lima. "Using a Dual CRISPR/Cas9 Approach to Gain Insight into the Role of LRP1B in Glioblastoma". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241411285.
    10.3390/ijms241411285
  6. Bárbara Alves; Joana Peixoto; Sofia Macedo; Jorge Pinheiro; Bruno Carvalho; Paula Soares; Jorge Lima; Raquel T. Lima. "High VEGFA Expression Is Associated with Improved Progression-Free Survival after Bevacizumab Treatment in Recurrent Glioblastoma". Cancers (2023): https://doi.org/10.3390/cancers15082196.
    10.3390/cancers15082196
  7. Rita Mota; Raquel T. Lima; Carlos Flores; Juliana F. Silva; Beatriz Cruz; Bárbara Alves; Marta T. Pinto; et al. "Assessing the Antitumor Potential of Variants of the Extracellular Carbohydrate Polymer from Synechocystis ¿sigF Mutant". Polymers (2023): https://doi.org/10.3390/polym15061382.
    10.3390/polym15061382
  8. Diana Sousa; Raquel T. Lima; Vanessa Lopes-Rodrigues; Esperanza Gonzalez; Félix Royo; Cristina P. R. Xavier; Juan M. Falcón-Pérez; M. Helena Vasconcelos. "Different Ability of Multidrug-Resistant and -Sensitive Counterpart Cells to Release and Capture Extracellular Vesicles". Cells 10 11 (2021): 2886-2886. https://doi.org/10.3390/cells10112886.
    10.3390/cells10112886
  9. Catarina Príncipe; Isabel J. Dionísio de Sousa; Hugo Prazeres; Paula Soares; Raquel T. Lima. Corresponding author: Raquel T. Lima. "LRP1B: A Giant Lost in Cancer Translation". Pharmaceuticals 14 9 (2021): 836-836. https://doi.org/10.3390/ph14090836.
    10.3390/ph14090836
  10. Dionísio de Sousa, Isabel; Ana Isabel Cunha; Inês A. Saraiva; Raquel V. Portugal; Etel R. P. Gimba; Marcos Guimarães; Hugo Prazeres; Paula Soares; Raquel T. Lima. Corresponding author: Raquel T. Lima. "LRP1B expression as a putative predictor of response to pegylated liposomal doxorubicin treatment in ovarian cancer". Pathobiology (2021): https://doi.org/10.1159/000517372.
    Published
  11. Isabel J. Dionísio de Sousa; Durval S. Marques; Catarina Príncipe; Raquel V. Portugal; Sule Canberk; Hugo Prazeres; José M. Lopes; et al. Corresponding author: Raquel T. Lima. "Predictive Biomarkers and Patient Outcome in Platinum-Resistant (PLD-Treated) Ovarian Cancer". Diagnostics 10 8 (2020): 525-525. https://doi.org/10.3390/diagnostics10080525.
    Published • 10.3390/diagnostics10080525
  12. Diana Sousa; Rune Matthiesen; Raquel T. Lima; M. Helena Vasconcelos. "Deep Sequencing Analysis Reveals Distinctive Non-Coding RNAs When Comparing Tumor Multidrug-Resistant Cells and Extracellular Vesicles with Drug-Sensitive Counterparts". Cancers 12 1 (2020): 200-200. https://doi.org/10.3390/cancers12010200.
    10.3390/cancers12010200
  13. Pereira, Daniela; Raquel T. Lima; Palmeira, Andreia; Seca, Hugo; Soares, Joana; Gomes, Sara; Raimundo, Liliana; et al. "Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold". Arabian Journal of Chemistry 12 8 (2019): 4150-4161. http://dx.doi.org/10.1016/j.arabjc.2016.04.015.
    Published • 10.1016/j.arabjc.2016.04.015
  14. Lopes-Rodrigues, Vanessa; Raquel T. Lima; Xavier, Cristina PR; Osório, Hugo; Sousa, Diana; Assaraf, Yehuda G.; Vasconcelos, M. Helena. "ALIX protein analysis: storage temperature may impair results". Journal of Molecular and Clinical Medicine 2 2 (2019): 29-34. https://jmcm.imrpress.com/EN/10.31083/j.jmcm.2019.02.7161.
    Published
  15. Flores, C.; Raquel T. Lima; Adessi, A.; Sousa, A.; Pereira, S.B.; Granja, P.L.; De Philippis, R.; Soares, P.; Tamagnini, P.. "Characterization and antitumor activity of the extracellular carbohydrate polymer from the cyanobacterium Synechocystis ¿sigF mutant". International Journal of Biological Macromolecules 136 (2019): 1219-1227. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068191226&partnerID=MN8TOARS.
    Published • 10.1016/j.ijbiomac.2019.06.152
  16. Raquel T. Lima; Diana Sousa; Ana Sara Gomes; Nuno Mendes; Rune Matthiesen; Madalena Pedro; Franklim Marques; et al. "The Antitumor Activity of a Lead Thioxanthone is Associated with Alterations in Cholesterol Localization". Molecules 23 (2018): 3301. http://www.mdpi.com/1420-3049/23/12/3301.
    Published • 10.3390/molecules23123301
  17. Isabel Sousa; Filipa Rodrigues; Hugo Prazeres; Raquel T. Lima; Paula Soares. "Liposomal therapies in oncology: does one size fit all?". Cancer Chemotherapy and Pharmacology 82 (2018): 741-755. https://doi.org/10.1007/s00280-018-3668-7.
    Published • 10.1007/s00280-018-3668-7
  18. Ferreira, L.B.; Raquel T. Lima; Bastos, A.C.S.D.F.; Silva, A.M.; Tavares, C.; Pestana, A.; Rios, E.; et al. "OPNa overexpression is associated with matrix calcification in thyroid cancer cell lines". International Journal of Molecular Sciences 19 10 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85054055672&partnerID=MN8TOARS.
    Published • 10.3390/ijms19102990
  19. Bizarro, A.; Sousa, D.; Raquel T. Lima; Musso, L.; Cincinelli, R.; Zuco, V.; De Cesare, M.; Dallavalle, S.; Vasconcelos, M.H.. "Synthesis and evaluation of the tumor cell growth inhibitory potential of new putative HSP90 inhibitors". Molecules 23 2 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85042237059&partnerID=MN8TOARS.
    Published • 10.3390/molecules23020407
  20. Lopes-Rodrigues, V.; Di Luca, A.; Mleczko, J.; Meleady, P.; Henry, M.; Pesic, M.; Cabrera, D.; et al. "Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles". Scientific Reports 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85015308172&partnerID=MN8TOARS.
    10.1038/srep44541
  21. Silva, P.M.A.; Ribeiro, N.; Raquel T. Lima; Andrade, C.; Diogo, V.; Teixeira, J.; Florindo, C.; et al. "Suppression of spindly delays mitotic exit and exacerbates cell death response of cancer cells treated with low doses of paclitaxel". Cancer Letters 394 (2017): 33-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014640901&partnerID=MN8TOARS.
    Published • 10.1016/j.canlet.2017.02.024
  22. Lopes-Rodrigues, V.; Oliveira, A.; Correia-da-Silva, M.; Pinto, M.; Raquel T. Lima; Sousa, E.; Vasconcelos, M.H.. "A novel curcumin derivative which inhibits P-glycoprotein, arrests cell cycle and induces apoptosis in multidrug resistance cells". Bioorganic and Medicinal Chemistry 25 2 (2017): 581-596. http://www.scopus.com/inward/record.url?eid=2-s2.0-85007239958&partnerID=MN8TOARS.
    Published • 10.1016/j.bmc.2016.11.023
  23. Grácio, Daniela; Magro, Fernando; Raquel T. Lima; Máximo, Valdemar. "An overview on the role of autophagy in cancer therapy". Hematology & Medical Oncology 2 1 (2017): http://dx.doi.org/10.15761/hmo.1000117.
    Published • 10.15761/hmo.1000117
  24. Pereira, Joana; Lopes-Rodrigues, Vanessa; Xavier, Cristina; Lima, M.; Raquel T. Lima; Ferreira, Isabel; Vasconcelos, M.. "An Aqueous Extract of Tuberaria lignosa Inhibits Cell Growth, Alters the Cell Cycle Profile, and Induces Apoptosis of NCI-H460 Tumor Cells". Molecules 21 5 (2016): 595. http://dx.doi.org/10.3390/molecules21050595.
    Published • 10.3390/molecules21050595
  25. Vizetto-Duarte, Catarina; Custódio, Luísa; Acosta, Gerardo; Lago, João H.G.; Morais, Thiago R.; Bruno de Sousa, Carolina; Gangadhar, Katkam N.; et al. "Can macroalgae provide promising anti-tumoral compounds? A closer look at Cystoseira tamariscifolia as a source for antioxidant and anti-hepatocarcinoma compounds". PeerJ 4 (2016): e1704. http://dx.doi.org/10.7717/peerj.1704.
    Published • 10.7717/peerj.1704
  26. Lopes-Rodrigues, V.; Di Luca, A.; Sousa, D.; Seca, H.; Meleady, P.; Henry, M.; Raquel T. Lima; O'Connor, R.; Vasconcelos, M.H.. "Data supporting the shedding of larger extracellular vesicles by multidrug resistant tumour cells". Data in Brief 6 (2016): 1023-1027. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957899956&partnerID=MN8TOARS.
    10.1016/j.dib.2016.02.004
  27. Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)". Autophagy 12 1 (2016): 1-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013763791&partnerID=MN8TOARS.
    Published • 10.1080/15548627.2015.1100356
  28. Barbosa, J.; Raquel T. Lima; Sousa, D.; Gomes, A.S.; Palmeira, A.; Seca, H.; Choosang, K.; et al. "Screening a small library of xanthones for antitumor activity and identification of a hit compound which induces apoptosis". Molecules 21 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85000443221&partnerID=MN8TOARS.
    Published • 10.3390/molecules21010081
  29. Raquel T. Lima; Sousa, D.; Paiva, A.M.; Palmeira, A.; Barbosa, J.; Pedro, M.; Pinto, M.M.; Sousa, E.; Vasconcelos, M.H.. "Modulation of Autophagy by a Thioxanthone Decreases the Viability of Melanoma Cells". Molecules (Basel, Switzerland) 21 10 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85016924980&partnerID=MN8TOARS.
    Published • 10.3390/molecules21101343
  30. Lopes-Rodrigues, V.; Di Luca, A.; Sousa, D.; Seca, H.; Meleady, P.; Henry, M.; Raquel T. Lima; O'Connor, R.; Vasconcelos, M.H.. "Multidrug resistant tumour cells shed more microvesicle-like EVs and less exosomes than their drug-sensitive counterpart cells". Biochimica et Biophysica Acta - General Subjects 1860 3 (2016): 618-627. http://www.scopus.com/inward/record.url?eid=2-s2.0-84953790097&partnerID=MN8TOARS.
    Published • 10.1016/j.bbagen.2015.12.011
  31. Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; et al. "Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356". Autophagy 12 2 (2016): 443-443. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054826264&partnerID=MN8TOARS.
    Published • 10.1080/15548627.2016.1147886
  32. Raquel T. Lima; Sousa, Diana; Gomes, A.S.; Mendes, N.; Matthiesen, Rune; Pedro, Madalena; Pinto, Madalena M. M; Sousa, Emília; Vasconcelos, M. Helena. "ABSTRACT:"Antitumor Activity of TXA1, an Autophagy Inducer which Affects Cholesterol Localization"". Pharmaceuticals 9 15 (2016): 7.
    Published
  33. Sousa, Diana; Raquel T. Lima; Vasconcelos, M. Helena. "Intercellular Transfer of Cancer Drug Resistance Traits by Extracellular Vesicles". Trends in Molecular Medicine 21 10 (2015): 595-608. http://dx.doi.org/10.1016/j.molmed.2015.08.002.
    Published • 10.1016/j.molmed.2015.08.002
  34. Sousa, M.E.; Palmeira, A.; Oliveira, A.; Lopes-Rodrigues, V.; Correia-da-Silva, M.; Raquel T. Lima (FC1C-BA48-38A6); Vasconcelos, M.H.; Pinto, M.. "ABSTRACT: "Thioxanthones derivatives as dual inhibitors of P-glycoprotein and tumor cell growth"". Toxicology Letters 238 2 (2015): S49. http://dx.doi.org/10.1016/j.toxlet.2015.08.137.
    Published • 10.1016/j.toxlet.2015.08.137
  35. Reis, Filipa; Lima, Raquel; Morales, Patricia; Ferreira, Isabel; Vasconcelos, M.. "Methanolic Extract of Ganoderma lucidum Induces Autophagy of AGS Human Gastric Tumor Cells". Molecules 20 10 (2015): 17872-17882. http://dx.doi.org/10.3390/molecules201017872.
    Published • 10.3390/molecules201017872
  36. Bizarro, Ana; Ferreira, Isabel; Sokovic, Marina; van Griensven, Leo; Sousa, Diana; Vasconcelos, M.; Raquel T. Lima. "Cordyceps militaris (L.) Link Fruiting Body Reduces the Growth of a Non-Small Cell Lung Cancer Cell Line by Increasing Cellular Levels of p53 and p21". Molecules 20 8 (2015): 13927-13940. http://dx.doi.org/10.3390/molecules200813927.
    Published • 10.3390/molecules200813927
  37. Lopes-Rodrigues, Vanessa; Di Luca, Alessio; Seca, Hugo; Meleady, Paula; Henry, Michael; Raquel T. Lima; O'Connor, Robert; Vasconcelos, M. Helena. "ABSTRACT: "P-gp Overexpressing MDR cells shed larger extracellular vesicles than their drug-sensitive counterparts"". Cancer Research 75 (2015): 4433.
    Published
  38. Reis, FS; Raquel T. Lima; Morales, P; Ferreira, ICFR; Vasconcelos, MH. "ABSTRACT: A cold methanolic extract of Ganoderma lucidum (Curtis) P. Karst induces autophagy in a gastric cancer cell line". Planta Medica 80 16 (2014): http://dx.doi.org/10.1055/s-0034-1394691.
    Published • 10.1055/s-0034-1394691
  39. Lima, M. João; Sousa, Diana; Raquel T. Lima; Carvalho, Ana Maria; Ferreira, Isabel C.F.R.; Vasconcelos, M. Helena. "Flower extracts of Filipendula ulmaria (L.) Maxim inhibit the proliferation of the NCI-H460 tumour cell line". Industrial Crops and Products 59 (2014): 149-153. http://dx.doi.org/10.1016/j.indcrop.2014.05.009.
    Published • 10.1016/j.indcrop.2014.05.009
  40. dos Santos, Tiago; Oliveira, Marta; Sousa, Diana; Raquel T. Lima; Martins, Anabela; Ferreira, Isabel C.F.R.; Vasconcelos, M. Helena; et al. "Suillus luteus methanolic extract inhibits proliferation and increases expression of p-H2A.X in a non-small cell lung cancer cell line". Journal of Functional Foods 6 (2014): 100-106. http://dx.doi.org/10.1016/j.jff.2013.09.023.
    Published • 10.1016/j.jff.2013.09.023
  41. Almeida, G.M.; Raquel T. Lima; Seca, H.; Vasconcelos, M.H.; Bergantim, R.; Guimarães, J.E.; Sobrinho-Simões, M.. "Effect of miR-128 in DNA damage of HL-60 acute myeloid leukemia cells". Current Pharmaceutical Biotechnology 15 5 (2014): 492-502. http://www.scopus.com/inward/record.url?eid=2-s2.0-84907184167&partnerID=MN8TOARS.
    Published • 10.2174/1389201015666140519122524
  42. Costa, E.V.; Sousa, E.; Choosang, K.; Singh, S.; Rocha, J.; Raquel T. Lima (FC1C-BA48-38A6); Pakkong, P.; et al. "Structure based design, synthesis, and evaluation of potential inhibitors of steroid sulfatase". Current Topics in Medicinal Chemistry 14 8 (2014): 1033-1044. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903714075&partnerID=MN8TOARS.
    Published • 10.2174/1568026614666140324124807
  43. Pereira, C.; Lopes-Rodrigues, V.; Coutinho, I.; Neves, M.P.; Raquel T. Lima; Pinto, M.; Cidade, H.; Vasconcelos, M.H.; Saraiva, L.. "Potential small-molecule activators of caspase-7 identified using yeast-based caspase-3 and -7 screening assays". European Journal of Pharmaceutical Sciences 54 1 (2014): 8-16. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893050056&partnerID=MN8TOARS.
    Published • 10.1016/j.ejps.2013.12.017
  44. Lopes-Rodrigues, V.; Seca, H.; Sousa, D.; Sousa, E.; Raquel T. Lima (FC1C-BA48-38A6); Vasconcelos, M.H.. "The network of P-glycoprotein and microRNAs interactions". International Journal of Cancer 135 2 (2014): 253-263. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900001904&partnerID=MN8TOARS.
    Published • 10.1002/ijc.28500
  45. Oliveira, Marta; Reis, Filipa S.; Sousa, Diana; Tavares, Catarina; Raquel T. Lima; Ferreira, Isabel C. F. R.; Santos, Tiago dos; et al. "A methanolic extract of Ganoderma lucidum fruiting body inhibits the growth of a gastric cancer cell line and affects cellular autophagy and cell cycle". Food Funct. 5 7 (2014): 1389-1394. http://dx.doi.org/10.1039/c4fo00258j.
    Published • 10.1039/c4fo00258j
  46. Seca, Hugo; Raquel T. Lima; Almeida, Gabriela M.; Sobrinho-Simões, Manuel; Bergantim, Rui; Guimaraes, Jose E.; Vasconcelos, M. Helena. "ABSTRACT: "Mir-128 and DNA Damage In Acute Myeloid Leukemia"". Blood 122 21 (2013): 2533-2533. http://dx.doi.org/10.1182/blood.v122.21.2533.2533.
    Published • 10.1182/blood.v122.21.2533.2533
  47. Raquel T. Lima (FC1C-BA48-38A6); Barron, G.A.; Grabowska, J.A.; Bermano, G.; Kaur, S.; Roy, N.; Vasconcelos, M.H.; Lin, P.K.T.. "Cytotoxicity and cell death mechanisms induced by a novel bisnaphthalimidopropyl derivative against the NCI-H460 non-small lung cancer cell line". Anti-Cancer Agents in Medicinal Chemistry 13 3 (2013): 414-421. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876702523&partnerID=MN8TOARS.
    Published • 10.2174/1871520611313030005
  48. Sousa, E.; Palmeira, A.; Cordeiro, A.S.; Sarmento, B.; Ferreira, D.; Raquel T. Lima (FC1C-BA48-38A6); Helena Vasconcelos, M.; Pinto, M.. "Bioactive xanthones with effect on P-glycoprotein and prediction of intestinal absorption". Medicinal Chemistry Research 22 5 (2013): 2115-2123. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879681792&partnerID=MN8TOARS.
    Published • 10.1007/s00044-012-0203-y
  49. Seca, H.; Lopes-Rodrigues, V.; Guimarães, J.E.; Almeida, G.M.; Vasconcelos, M.H.. "Targeting miR-21 induces autophagy and chemosensitivity of leukemia cells". Current Drug Targets 14 10 (2013): 1135-1143. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881353774&partnerID=MN8TOARS.
    Published • 10.2174/13894501113149990185
  50. Queiroz, M.-J.R.P.; Peixoto, D.; Calhelha, R.C.; Soares, P.; Dos Santos, T.; Raquel T. Lima (FC1C-BA48-38A6); Campos, J.F.; et al. "New di(hetero)arylethers and di(hetero)arylamines in the thieno[3,2-b]pyridine series: Synthesis, growth inhibitory activity on human tumor cell lines and non-tumor cells, effects on cell cycle and on programmed cell death". European Journal of Medicinal Chemistry 69 (2013): 855-862. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885340733&partnerID=MN8TOARS.
    Published • 10.1016/j.ejmech.2013.09.023
  51. Azevedo, C.M.G.; Afonso, C.M.M.; Soares, J.X.; Reis, S.; Sousa, D.; Vasconcelos, M.H.; Pedro, M.; et al. "Pyranoxanthones: Synthesis, growth inhibitory activity on human tumor cell lines and determination of their lipophilicity in two membrane models". European Journal of Medicinal Chemistry 69 (2013): 798-816. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885009924&partnerID=MN8TOARS.
    Published • 10.1016/j.ejmech.2013.09.012
  52. Paiva, A.M.; Pinto, R.A.; Teixeira, M.; Barbosa, C.M.; Vasconcelos, M.H.; Sousa, E.; Pinto, M.. "Development of noncytotoxic PLGA nanoparticles to improve the effect of a new inhibitor of p53-MDM2 interaction". International Journal of Pharmaceutics 454 1 (2013): 394-402. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884149481&partnerID=MN8TOARS.
    Published • 10.1016/j.ijpharm.2013.07.017
  53. Azevedo, C.M.G.; Afonso, C.M.M.; Sousa, D.; Raquel T. Lima (FC1C-BA48-38A6); Helena Vasconcelos, M.; Pedro, M.; Barbosa, J.; et al. "Multidimensional optimization of promising antitumor xanthone derivatives". Bioorganic and Medicinal Chemistry 21 11 (2013): 2941-2959. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877815889&partnerID=MN8TOARS.
    Published • 10.1016/j.bmc.2013.03.079
  54. Seca, H.; Palmeira, A.; Fernandes, M.X.; Castro, F.; Correia-da-Silva, M.; Nascimento, M.S.J.; Sousa, E.; Pinto, M.; Vasconcelos, M.H.. "Sulfated small molecules targeting EBV in Burkitt lymphoma: From in silico screening to the evidence of in vitro effect on viral episomal DNA". Chemical Biology and Drug Design 81 5 (2013): 631-644. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876827905&partnerID=MN8TOARS.
    Published • 10.1111/cbdd.12109
  55. Raquel T. Lima; Sousa, Diana; Choosang, K.; Pakkong, P.; Palmeira, A.; Paiva, A. M.; Seca, Hugo; et al. "ABSTRACT:"A Potent thioxanthone which induces autophagy and cell death in a melanoma cell line”". Annals of Oncology 24 Supplem 1 (2013): i23-i26.
    Published
  56. Lima, R.T.; Barron, G.; Grabowska, J.A.; Bermano, G.; Kaur, S.; Roy, N.; Vasconcelos, M.H.; Lin, P.K.. "ABSTRACT: Bisnaphthalimidopropyl Derivatives as Antitumor Agents –Targeting SIRT2". European Journal of Cancer 48 (2012): S243. http://dx.doi.org/10.1016/s0959-8049(12)71623-4.
    Published • 10.1016/s0959-8049(12)71623-4
  57. Calhelha, Ricardo C.; Ferreira, Isabel C. F. R.; Peixoto, Daniela; Abreu, Rui M. V.; Vale-Silva, Luís A.; Pinto, Eugénia; Raquel T. Lima; et al. "Aminodi(hetero)arylamines in the Thieno[3,2-b]pyridine Series: Synthesis, Effects in Human Tumor Cells Growth, Cell Cycle Analysis, Apoptosis and Evaluation of Toxicity Using Non-Tumor Cells". Molecules 17 4 (2012): 3834-3843. http://dx.doi.org/10.3390/molecules17043834.
    Published • 10.3390/molecules17043834
  58. Raquel T. Lima; Belaz, K.R.A.; Denadai, M.; Almeida, A.P.; Lima, R.T.; Vasconcelos, M.H.; Pinto, M.M.; Cass, Q.B.; Oliveira, R.V.. "Enantiomeric resolution of albendazole sulfoxide by semipreparative HPLC and in vitro study of growth inhibitory effects on human cancer cell lines". Journal of Pharmaceutical and Biomedical Analysis 66 (2012): 100-108. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861222683&partnerID=MN8TOARS.
    Published • 10.1016/j.jpba.2012.03.012
  59. Neves, M.P.; Raquel T. Lima (FC1C-BA48-38A6); Choosang, K.; Pakkong, P.; De São José Nascimento, M.; Vasconcelos, M.H.; Pinto, M.; Silva, A.M.S.; Cidade, H.. "Synthesis of a natural chalcone and its prenyl analogs - Evaluation of tumor cell growth-inhibitory activities, and effects on cell cycle and apoptosis". Chemistry and Biodiversity 9 6 (2012): 1133-1143. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862534164&partnerID=MN8TOARS.
    Published • 10.1002/cbdv.201100190
  60. Neves, M.P.; Cravo, S.; Raquel T. Lima (FC1C-BA48-38A6); Vasconcelos, M.H.; Nascimento, M.S.J.; Silva, A.M.S.; Pinto, M.; Cidade, H.; Corrêa, A.G.. "Solid-phase synthesis of 2'-hydroxychalcones. Effects on cell growth inhibition, cell cycle and apoptosis of human tumor cell lines". Bioorganic and Medicinal Chemistry 20 1 (2012): 25-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855202674&partnerID=MN8TOARS.
    Published • 10.1016/j.bmc.2011.11.042
  61. Seca, Hugo; Almeida, Gabriela M.; Lopes-Rodrigues, Vanessa; Raquel T. Lima; Guimarães, José E.; Vasconcelos, M. Helena. "ABSTRACT: “Downregulation of miR-21 expression induces autophagy and increases the sensitivity of K562 chronic myeloid leukemia to etoposide and doxorubicin”". Annals of Oncology 23 1 (2012): i26-i44.
    Published
  62. Seca, Hugo; Raquel T. Lima; Almeida, G.M.; Lopes-Rodrigues, Vanessa; Guimarães, José E.; Vasconcelos, M. Helena. "ABSTRACT: "Evidence for induction of autophagy by antimiR-21"". European Journal of Cancer Supplements 48 Supplem 5 (2012): S106.
    Published
  63. Seca, Hugo; Raquel T. Lima; Lopes-Rodrigues, Vanessa; Guimarães, José E.; Vasconcelos, M. Helena. "ABSTRACT: “AntimiR-21 causes autophagy in the K562 cell line and sensitizes cells to the effect of doxorubicin and etoposide”. (ASH Annual Meeting Abstracts) 120: Abstract 4908.". Blood 120 (2012): Abstract 4908.
    Published
  64. Marta Perro Neves; Honorina Cidade; Madalena Pinto; Artur M. S. Silva; Luis Gales; Ana Margarida Damas; Raquel T. Lima; M. Helena Vasconcelos; Maria de Sao Jose Nascimento. "ChemInform Abstract: Prenylated Derivatives of Baicalein and 3,7-Dihydroxyflavone: Synthesis and Study of Their Effects on Tumor Cell Lines Growth, Cell Cycle and Apoptosis.". ChemInform 42 36 (2011): no-no. http://dx.doi.org/10.1002/chin.201136201.
    10.1002/chin.201136201
  65. Neves, M.P.; Cidade, H.; Pinto, M.; Silva, A.M.S.; Gales, L.; Damas, A.M.; Vasconcelos, M.H.; Nascimento, M.D.S.J.. "Prenylated derivatives of baicalein and 3,7-dihydroxyflavone: Synthesis and study of their effects on tumor cell lines growth, cell cycle and apoptosis". European Journal of Medicinal Chemistry 46 6 (2011): 2562-2574. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955635866&partnerID=MN8TOARS.
    Published • 10.1016/j.ejmech.2011.03.047
  66. Seca, H.; Raquel T. Lima (FC1C-BA48-38A6); Guimarães, J.E.; Vasconcelos, M.H.. "Simultaneous targeting of P-gp and XIAP with siRNAs increases sensitivity of P-gp overexpressing CML cells to imatinib". Hematology 16 2 (2011): 100-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952643800&partnerID=MN8TOARS.
    Published • 10.1179/102453311X12940641877803
  67. Raquel T. Lima (FC1C-BA48-38A6); Seca, H.; Soares, P.; Nascimento, M.S.J.; Vasconcelos, M.H.. "EBV interferes with the sensitivity of burkitt lymphoma akata cells to etoposide". Journal of Cellular Biochemistry 112 1 (2011): 200-210. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651286710&partnerID=MN8TOARS.
    Published • 10.1002/jcb.22920
  68. Raquel T. Lima (FC1C-BA48-38A6); Seca, H.; Brás, S.; Nascimento, M.S.J.; Vasconcelos, M.H.. "Treatment of Akata EBV-positive cells with doxorubicin causes more EBV reactivation than treatment with etoposide". Chemotherapy 57 3 (2011): 195-203. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955433172&partnerID=MN8TOARS.
    Published • 10.1159/000323627
  69. Borralho, P.M.; Simões, A.E.S.; Gomes, S.E.; Raquel T. Lima (FC1C-BA48-38A6); Carvalho, T.; Ferreira, D.M.S.; Vasconcelos, M.H.; Castro, R.E.; Rodrigues, C.M.P.. "MiR-143 overexpression impairs growth of human colon carcinoma xenografts in mice with induction of apoptosis and inhibition of proliferation". PLoS ONE 6 8 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80052061782&partnerID=MN8TOARS.
    Published • 10.1371/journal.pone.0023787
  70. Raquel T. Lima (FC1C-BA48-38A6); Busacca, S.; Almeida, G.M.; Gaudino, G.; Fennell, D.A.; Vasconcelos, M.H.. "MicroRNA regulation of core apoptosis pathways in cancer". European Journal of Cancer 47 2 (2011): 163-174. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650686123&partnerID=MN8TOARS.
    Published • 10.1016/j.ejca.2010.11.005
  71. Azevedo, C. M. G.; Afonso, C. M. M.; Soares, J. X.; Reis, S.; Raquel T. Lima; Pedro, Madalena; Pinto, Madalena M. M.. "ABSTRACT: "Multidimensional optimization of xanthone derivatives with potential antitumour activity”". Revista Portuguesa de Farmácia LII 6 Suplem (2011): 81-82.
    Published
  72. Almeida, A. P.; Macedo, B.; Cravo, S.; Dethoup, T.; Raquel T. Lima; Vasconcelos, M. Helena; Pinto, Madalena M. M; Kijjoa, Anake. "ABSTRACT: “The marine fungi Eurotium cristatum: chemical study, evaluation of growth inhibition effect on human tumor cell lines and development of HPLC analysis”.". Revista POrtuguesa de Farmácia LII 6 Suplem (2011): 79-80.
    Published
  73. Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Abreu, R. M. V.; Raquel T. Lima; Silva, L. A. V.; Pinto, E.; Alvelos, M. Inês; Vasconcelos, M. Helena; Queiroz, Maria-João R. P.. "ABSTRACT: “Synthesis of aminodiarylamines in the thieno[3,2-b]piridine series and effects on tumour cell growth inhibition, cell cycle and apoptosis”.". Revista Portuguesa de Farmácia LII 6 Suplem (2011): 77-78.
    Published
  74. Abreu, R.M.V.; Ferreira, I.C.F.R.; Calhelha, R.C.; Lima, R.T.; Vasconcelos, M.H.; Adega, F.; Chaves, R.; Queiroz, M.-J.R.P.. "Anti-hepatocellular carcinoma activity using human HepG2 cells and hepatotoxicity of 6-substituted methyl 3-aminothieno[3,2-b]pyridine-2- carboxylate derivatives: In vitro evaluation, cell cycle analysis and QSAR studies". European Journal of Medicinal Chemistry 46 12 (2011): 5800-5806. http://www.scopus.com/inward/record.url?eid=2-s2.0-80955172000&partnerID=MN8TOARS.
    10.1016/j.ejmech.2011.09.029
  75. Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Abreu, R. M. V.; Raquel T. Lima; Silva, L. A. V.; Pinto, E.; Alvelos, M. Inês; Vasconcelos, M. Helena; Queiroz, Maria-João R. P.. Corresponding author: Queiroz, Maria-João R. P.. "Synthesis of aminodiarylamines in the thieno[3,2-b]piridine series and effects on tumour cell growth inhibition, cell cycle and apoptosis". Revista Portuguesa de Farmácia LII 6 Suplem (2011): 77-78.
    Published
  76. Queiroz, M.-J.R.P.; Calhelha, R.C.; Vale-Silva, L.A.; Pinto, E.; Raquel T. Lima (FC1C-BA48-38A6); Vasconcelos, M.H.. "Efficient synthesis of 6-(hetero)arylthieno[3,2-b]pyridines by Suzuki-Miyaura coupling. Evaluation of growth inhibition on human tumor cell lines, SARs and effects on the cell cycle". European Journal of Medicinal Chemistry 45 12 (2010): 5628-5634. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649335089&partnerID=MN8TOARS.
    Published • 10.1016/j.ejmech.2010.09.014
  77. Palmeira, A.; Paiva, A.; Sousa, E.; Seca, H.; Almeida, G.M.; Fernandes, M.X.; Pinto, M.; Vasconcelos, M.H.. "Insights into the in vitro antitumor mechanism of action of a new pyranoxanthone". Chemical Biology and Drug Design 76 1 (2010): 43-58. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953008434&partnerID=MN8TOARS.
    Published • 10.1111/j.1747-0285.2010.00978.x
  78. Almeida, Ana Paula; Cardoso, A. A. Q. P.; Macedo, B.; Dethoup, T.; Raquel T. Lima; Vasconcelos, M. Helena; Pinto, Madalena M. M; Kijjoa, Anake. "Evaluation Of The Growth Inhibitory Effect Of The Crude Extract And The Secondary Metabolites Obtained From The Marine Sponge-Associated Fungus Eurotium cristatum On Three Human Tumour Cell Lines". Journal of Natural Pharmaceuticals 1 1 (2010): 25-29.
    Published
  79. Borralho, P.M.; Gomes, S. M.; Raquel T. Lima; Castro, Rui E.; Vasconcelos, M. Helena; Rodrigues, Cecilia M. P.. "ABSTRACT: “miR-143 over-expression reduces the growth of xenograft tumors from colon carcinoma cells”". BMC Proceedings 4 Suppl 2 (2010): P59.
    Published
  80. Almeida, A. P.; Cardoso, A. A. Q. P.; Macedo, B.; Dethoup, T.; Raquel T. Lima; Vasconcelos, M. Helena; Pinto, Madalena M. M.; Kijjoa, Anake. "ABSTRACT:“Secondary metabolites from Eurotium cristatum: isolation and evaluation of growth inhibition effect on human tumor cell lines”.". Revista Portuguesa de Farmácia LII 4 Suplem (2010): 66.
    Published
  81. Perro-Neves, Marta; Flor, J.; Cidade, Honorina; Pinto, Madalena M. M.; Silva, A. M. S.; Raquel T. Lima; Vasconcelos, M. Helena; De São José Nascimento, M.. "ABSTRACT:“Synthesis of prenylated derivatives of baicalein as interesting apoptosis inducers”.". Revista Portuguesa de Farmácia LII 4 (2010): 15.
    Published
  82. Sousa, Emília; Costa, E.; Paiva, A. M.; Nazareth, N.; Pereira, J.; Seca, Hugo; Raquel T. Lima; et al. "ABSTRACT:“Oxygenated xanthones as models for novel antitumor compounds”". Revista Portuguesa de Farmácia LII 3 suplemen (2008): 153.
    Published
  83. Palmeira, A.; Paiva, A.M.; Sousa, Emília; Pinto, Madalena M. M; Seca, Hugo; Almeida, Gabriela M.; Raquel T. Lima; Vasconcelos, M. Helena. "ABSTRACT: “XP13 - A novel xanthone derivative with antiproliferative and apoptotic effects in leukaemia cell line"". Revista Portuguesa de Farmácia LII 3 suplemen (2008): 24.
    Published
  84. Lima, J.; Sousa, Emília; Nazareth, N.; Seca, Hugo; Raquel T. Lima; Vasconcelos, M. Helena; De São José Nascimento, M.; Pinto, Madalena M. M. "ABSTRACT: "Parallel synthesis of xanthone derivatives for dual activity: antitumour activity and P-glycoprotein inhibition”. Rev. Port. Farmácia, LII (3) Suplemento: 154 (Poster Communication)". Revista Portugusa de Farmácia LII 3 Suplem (2008): 154.
    Published
  85. Seca, Hugo; Santos, L.; Figueiredo, Joana P.; Raquel T. Lima; Guimarães, José E.; Sambade, C.; Vasconcelos, M. Helena. "ABSTRACT:“Targeting XIAP for chemosensitization purposes: Different effect with different cytotoxic drugs”". Blood 112 11 (2008): 566.
    Published
  86. Raquel T. Lima; Guimarães, José E.; Vasconcelos, M. Helena. "Overcoming K562Dox resistance to STI571 (Gleevec) by downregulation of P-gp expression using siRNAs". Cancer Therapy 5 (2007): 67-76. https://pdfs.semanticscholar.org/1197/1da2ee8dbe32a378b5ffb8195bee804ad87d.pdf.
    Published
  87. Lima, R.T.; Martins, L.M.; Guimarães, J.E.; Sambade, C.; Vasconcelos, M.H.. "Chemosensitization effects of XIAP downregulation in K562 leukemia cells". Journal of Chemotherapy 18 1 (2006): 98-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645103808&partnerID=MN8TOARS.
  88. Seca, Hugo; Raquel T. Lima; Guimarães, José E.; Vasconcelos, M. Helena. "ABSTRACT: Evaluation of XIAP as a molecular target to increase sensitivity to Imatinib". Blood 108 11 (2006): 402a-40-3a.
    Published
  89. Raquel T. Lima; Martins, L. M.; Guimarães, José E.; Sambade, C.; Vasconcelos, M. Helena. "ABSTRACT: Overcoming Resistance to Imatinib Mesylate in a CML Cell Line by Downregulation of P-gp with siRNAs.". Blood 106 11 (2005): 1526.
    Published
  90. De Carvalho, M.; Linke, R.P.; Domingos, F.; Evangelista, T.; Ducla-Soares, J.L.; Nathrath, W.B.J.; Azevedo-Coutinho, C.; Raquel T. Lima (FC1C-BA48-38A6); Saraiva, M.J.. "Mutant fibrinogen A-a-chain associated with hereditary renal amyloidosis and peripheral neuropathy". Amyloid 11 3 (2004): 200-207. http://www.scopus.com/inward/record.url?eid=2-s2.0-4744342551&partnerID=MN8TOARS.
    Published • 10.1080/13506120400000772
  91. Raquel T. Lima (FC1C-BA48-38A6); Martins, L.M.; Guimarães, J.E.; Sambade, C.; Vasconcelos, M.H.. "Specific downregulation of bcl-2 and xIAP by RNAi enhances the effects of chemotherapeutic agents in MCF-7 human breast cancer cells". Cancer Gene Therapy 11 5 (2004): 309-316. http://www.scopus.com/inward/record.url?eid=2-s2.0-2342538514&partnerID=MN8TOARS.
    10.1038/sj.cgt.7700706
  92. Raquel T. Lima (FC1C-BA48-38A6); Martins, L. M.; Guimarães, José E.; Sambade, C.; Vasconcelos, M. Helena. "ABSTRACT: “RNAi mediated downregulation of bcl-2 and xIAP may have therapeutical potential in human breast adenocarcinoma”.". European Journal of Cancer Supplements 1 5 (2003): S292.
  93. Raquel T. Lima; Martins, L. M.; Silva, C. A.; Guimarães, José E.; Sambade, C.; Vasconcelos, M. Helena. "ABSTRACT: Downregulation of Bcl-2 by small interfering RNAs sensitizes MCF-7 human breast adenocarcinoma cells to chemotherapy induced death.". Rev. Port. Farmácia, LII(1) Suplemento: 77 LII 1 suplemen (2003): 77.
    Published
Newsletter article
  1. Bueno-Ferreira, L.; Raquel T. Lima; Bastos, A. C. S. F.; Silva, A. M.; Tavares, C. A.; Rios, Elizabete; Eloy, Catarina; et al. "OPNa Overexpression Is Associated with Matrix Calcification in Thyroid Cancer Cell Lines", ASPIC News , 2019, https://www.aspic.pt/pt-pt/noticias/sobre-express%C3%A3o-da-opna-est%C3%A1-associada-com-calcifica%C3%A7%C3%A3o-da-matriz-extracelular-em-linhas#.XkV7n1T7SUk.
  2. Silva, P.M.A.; Ribeiro, N.; Raquel T. Lima; Andrade, C.; Diogo, V.; Teixeira, J.; Florindo, C.; et al. "Suppression of spindly delays mitotic exit and exacerbates cell death response of cancer cells treated with low doses of paclitaxel", ASPIC News, 2017, https://www.aspic.pt/pt-pt/noticias/elimina%C3%A7%C3%A3o-da-spindly-um-gatilho-para-o-suic%C3%ADdio-de-c%C3%A9lulas-cancer%C3%ADgenas#.XkV6RlT7SUk.
  3. Lopes-Rodrigues, Vanessa; Di Luca, Alessio; Mleczko, J.; Henry, Michael; Cabrera, D.; Raquel T. Lima; O'Connor, Robert; Falcon-Perez, J.M.; M.Helena Vasconcelos. "Identification of the metabolic alterations associated with the multidrug resistant phenotype¿in cancer and their intercellular transfer mediated by extracellular vesicles", ASPIC News, 2017
  4. Raquel T. Lima; Sousa, Diana; Paiva, Ana M.; Palmeira, A.; Barbosa, J.; Pedro, Madalena; Pinto, Madalena M. M.; Sousa, Emília; Vasconcelos, M. Helena. "Modulation of autophagy by a thioxanthone decreases the viability of melanoma cells", ASPIC News , 2017, https://www.aspic.pt/pt-pt/node/5320#.XkV99VT7SUk.
  5. Lopes-Rodrigues, Vanessa; Di Luca, Alessio; Sousa, Diana; Seca, Hugo; Meleady, Paula; Henry, Michael; Raquel T. Lima; O'Connor, Robert; Vasconcelos, M. Helena. "Multidrug resistant tumour cells shed more microvesicle-like EVs and less exosomes than their drug-sensitive counterpart cells", ASPIC News, 2016
Thesis / Dissertation
  1. Lima, Raquel Maria Torres. "Relevance of Latent EBV infection in drug response of burkitt lymphoma cells". PhD, 2010. http://hdl.handle.net/10216/53912.
  2. Raquel T. Lima. "Sensitization of K562Dox cells to IMATIBINIB through P-glycoprotein RNAi decrease - Aumento da sensibilidade da linha celular K562Dox para efeitos do Imatinib pela diminuição da expressão da P-glicoproteína por RNAi". Master, Universidade do Porto Faculdade de Medicina, 2005.

Other

Invention
  1. National (Portugal) Provisional Patent application (Co-inventor): “Tamanho e perfil proteico de vesículas extracelulares como marcadores de multirresistência às terapêuticas anti-neoplásicas”; National patent related process nr: 107841.. 2015. Raquel T. Lima.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/12/15 Análise alargada do perfil genómico de tumores avançados: impacto na Oncologia de precisão através da análise de TMB e HRD 21º Congresso Nacional da Sociedade Portuguesa de Oncologia
Sociedade Portuguesa de Oncologia (SPO) (Coimbra, Portugal)
2020/11/04 "Drug sequestration by Extracellular Vesicles: preliminary evidence for a role of Pglycoprotein in this process" COST Action 17104 (STRATAGEM) WG3 Meeting - International Online Symposium on “New Therapeutic Tools Against Preclinical Models of Multidrug Resistant Tumors”
COST action 17104 (porto, Portugal)
2020/11/04 Multidrug Resistant cells show different ability to release and capture EVs than their sensitive counterparts: effect of endocytic pathway regulation COST Action 17104 (STRATAGEM) WG3 Meeting - International Online Symposium on “New Therapeutic Tools Against Preclinical Models of Multidrug Resistant Tumors”
COST action 17104 (Porto, Portugal)
2018/11/29 Characterization and anti-tumoral activity of an extracellular carbohydrate polymer from Synechocystis mutant lacking SigF regulator i3S Annual Meeting 2018
i3s/ IPATIMUP, INEB, IBMC (Póvoa de Varzim, Portugal)
2018/05/14 Alternative sigma factor F (SigF) regulates secretion and production of extracellular polysaccharides in Synechocystis sp. PCC 6803 3rd International EPNOE Junior Scientists Meeting - Advances in Fundamental and Applied Polysaccharide Research
International EPNOE (Maribor, Slovenia)
2017/07/20 The Mitotic Protein Spindly as a Cancer Therapeutic Target II Workshop IIFacts
CESPU (Gandra, Paredes, Portugal)
2017/02 The cell growth inhibitory effect of an aqueous extract of Tuberaria lignosa in NCI-H460 human tumor cells 10th Meeting of Young Investigators of the University of Porto
University of Porto (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/01/01 - Current "A swiss-knife nanotechnology approach to glioblastoma treatment"
Supervisor
 Neurosciences (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2021/09 - 2023/11/29 "Unravelling the role of mitochondrial TERT in a thryroid cancer cell lines"
Supervisor
 MSc Student in Health Biochemistry
Escola Superior de Educação – Instituto Politécnico do Porto , Portugal
2021/09/01 - 2022/12/02 Evaluation of Putative Glioblastoma Biomarkers in Patient Samples
Supervisor
 Mestrado em Bioquimica da Saude (Master)
2019/09/01 - 2020/12/17 Unraveling the role of LRP1B in human cancer with a CRISPR-Cas9 approach
Supervisor of Catarina Príncipe Ferreira dos Santos
 Biologia Celular e Molecular (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2018/09 - 2019/12/19 Estudo da Expressão da Proteína LRP1B em Tumores de Ovário
Supervisor
 Biologia Molecular e Celular (Master)
Universidade de Aveiro, Portugal
2013/09 - 2019/06/07 STUDYING EXTRACELLULAR VESICLES FROM P-GLYCOPROTEIN OVEREXPRESSING MULTIDRUG RESISTANT CELLS: NEW INSIGHTS INTO THEIR CARGO AND MECHANISMS OF RELEASE
Co-supervisor
 PhD in Pharmaceutical Sciences – Cell and Molecular Biology (PhD)
Universidade do Porto Faculdade de Farmácia, Portugal
2018 - 2018 Evaluation of the role of LRP1B in the response of human ovarian cancer cells to liposomal doxorubicin
Supervisor
 Bioquímica para a Saúde (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2011/11 - 2016/12 Understanding P-glycoprotein mediated Multidrug-resistance in Cancer: New potential targets, biomarkers and molecular inhibitors
Co-supervisor
 Pathology and Molecular Genetics (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 - 2014 Study of antitumor and immunomodulatory activities of wild mushroom extracts
Supervisor
 Genética Molecular (Master)
Universidade do Minho, Portugal
2012/09 - 2013/03 Determination of the activity of BNIP derivative compounds incorporated into liposomes against pancreatic tumor cells
Co-supervisor
 Mestrado em Tecnologia Farmacêutica (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2013 - 2013 Studying p53 family proteins: search for small molecule modulators
Co-supervisor
 Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/02/03 - 2023/02/05 Participation in the SPEDM Congress 2023/74ª Reunião Anual da SPEDM
Congress
 SPEDM Congress 2023/74ª Reunião Anual da SPEDM
Sociedade Portuguesa de Endocrinologia Diabetes e Metabolismo, Portugal
2022/09/05 - 2022/09/10 Science Outreach Activity- UNIVERSIDADE JÚNIOR | 15.ª EDIÇÃO Escola de Ciências da Vida e da Saúde High school students supervision at the lab
Workshop
 UNIVERSIDADE JÚNIOR | 15.ª EDIÇÃO Escola de Ciências da Vida e da Saúde
Universidade do Porto, Portugal
2022/02/21 - 2022/02/23 Seahorse XFe24 Training
Other
 Training Session_Seahorse XFe24
Agilent Technologies, Germany
2022/02/15 - 2022/02/15 Training_Seahorse XFe24 Installation and Familiarization
Other
 Seahorse XFe24 Installation and Familiarization
Agilent Technologies, Germany
2021/05/20 - 2021/05/21 Scientific Meeting: 27th Porto Cancer Meeting "Stemness and Metastasis: Advances in Research and Clinical Translation
Conference
 27th Porto Cancer Meeting "Stemness and Metastasis: Advances in Research and Clinical Translation
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/02/18 - 2021/02/21 Advanced course "Models of the Blood-Brain Barrier: Scientific Tools to Target the Brain" Online course 16.5h -Theoretical Sessions | Practical Sessions | Virtual Labs
Workshop
 "Models of the Blood-Brain Barrier: Scientific Tools to Target the Brain"
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/01/20 - 2021/01/22 Advanced Course in Experimental Design and Analysis of Data for Research with Animals (~20h)
Workshop
 Experimental Design and Analysis of Data for Research with Animals
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/10/07 - 2019/10/10 Advanced training: Flow Cytometry: From basic knowledge to advanced applications
Workshop
 Flow Cytometry: From basic knowledge to advanced applications
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/09/02 - 2019/09/07 Science Outreach Activity- UNIVERSIDADE JÚNIOR | 14.ª EDIÇÃO 14.ª Escola de Ciências da Vida e da Saúde High school students supervision at the lab
Other
 14.ª Escola de Ciências da Vida e da Saúde
Universidade do Porto, Portugal
2019/05/27 - 2019/05/31 Advanced course on HIGH THROUGHPUT SCREENING AND IMAGE ANALYSIS FOR BIOSCIENCES
Workshop
 HIGH THROUGHPUT SCREENING AND IMAGE ANALYSIS FOR BIOSCIENCES
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/09/03 - 2018/09/08 Science Outreach Activity- UNIVERSIDADE JÚNIOR | 13.ª EDIÇÃO 13.ª Escola de Ciências da Vida e da Saúde High school students supervision at the lab
Other
 13.ª Escola de Ciências da Vida e da Saúde
Universidade do Porto, Portugal
2018/07/09 - 2018/07/13 Science outreach activities - Ciencia Viva no Laboratorio 2018 High-school students supervision at the lab
Other
 Ciencia Viva no Laboratorio 2018
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/07/10 - 2018/07/12 Participation in the 2nd Small Meeting on Endocytic Trafficking and Signaling
Meeting
 2nd Small Meeting on Endocytic Trafficking and Signaling
Universidade do Minho Escola de Ciências, Portugal
2017/12/11 - 2017/12/13 Apresentação e Demonstração Seahorse - 4 h
Workshop
 Apresentação e Demonstração Seahorse 2017
Agilent Technologies, Germany

SOQUÌMICA, Portugal
2017/11/28 - 2017/11/28 Meeting da EORTC/Endrocrine Task Force and "Thyroid Group Study- SPEDM
Conference
 Meeting da EORTC/Endrocrine Task Force and "Thyroid Group Study- SPEDM
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2017/09/09 - 2017/09/09 Chairman in Sesssion - "13a Escola das Ciências da Saude e da Vida" - University of Porto
Workshop
 3a Escola das Ciências da Saude e da Vida" - University of Porto
Universidade do Porto, Portugal
2016/09/20 - 2016/09/20 Micro RNA by real time PCR
Seminar
 MicroRNA by Real time PCR. Tools to get it all
2016/05/31 - 2016/05/31 Water purification seminar
Seminar
 Water purification seminar
Merck SA, Portugal
2016/04/16 - 2016/04/16 Advanced Course: Flow Cytometry Workshop: DNA analysis and Cell Death Course
Workshop
 Flow Cytometry Workshop: DNA analysis and Cell Death Course
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2015/09/23 - 2015/09/26 Workshop on Compound Screening (With Grant) (20 hours) ESACT (European Society for Animal Cell Technology), Llfranc, Spain
Workshop
 ESACT Cells for Compound Screening course
ESACT (European Society for Animal Cell Technology), Germany

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/11/20 Examiner - Novas perspetivas sobre o papel da autofagia no carcinoma adrenocortical
(Thesis) Main arguer
 Marta Marques Alves (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2023/11/27 Examiner - Uncover the mechanism of action of new FeCp compounds in colorectal cancer cells
(Thesis) Main arguer
 Ana Paula Passos da Silva (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2021/12/16 Examiner - Targeting mitosis for cancer therapy: improving the efficacy of the second generation antimitotics and identifying new antimitotics
(Thesis) Arguer
 Pedro Henrique Alves Novais (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
2021/12/10 Examiner- Unravelling the Importance of MHC Class I in Colorectal Cancer Cell Stemness and Tumour Initiation
(Thesis) Arguer
 Ana Raquel da Silva Borralho (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2021/03/09 Tumor microenvironment (TME) factors in ovarian cancer - "Fatores do microambiente tumoral no cancro do ovário" (Vogal Não Orientador) Isabel José Dionísio de Sousa (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2020/12/17 Establishment of a LRP1B-Knockout Human Cancer Cell Line Model with a CRISP/Cas9 Approach
Supervisor
 Catarina Príncipe Ferreira dos Santos (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2020/12/14 Examiner- Unveiling the Transcriptional network behind gastric cancer stem cells phenotype"
(Thesis) Arguer
 Paula Cristina Pinto Figueira (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2019/12/19 Estudo do expressão da proteína LRP1B em tumores de ovário
Supervisor
 Ana Isabel Ribeiro da Cunha (Master)
Universidade de Aveiro, Portugal

Association member

Society Organization name Role
2022 - Current Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo Member 1083
2013 - Current ASPIC - Associação Portuguesa de Investigação em Cancro Member
2012 - Current EACR - European Association for Cancer Research Member
2016 - 2020 COST Action CA1513 - TRANSAUTOPHAGY - European Network of Multidisciplinary Research and Translation of Autophagy knowledge Member of Working Group 4 (WG4
2014 - 2016 GEIVEX - Grupo Espanol de Inovacion e Investigacion en Vesiculas Extracelulares Member

Committee member

Activity description
Role 		Institution / Organization
2015/09/30 - 2015/09/30 First Iberian meeting on Extracellular vesicles (Organization Committee)
Member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2017/09 - Current Biochemistry (chair) Fisioterapia (Licenciatura) Escola Superior de Saúde de Santa Maria, Portugal
2016/09 - Current Biochemistry (chair) Nursing (Licenciatura) Escola Superior de Saúde de Santa Maria, Portugal
2016 - Current Proliferation and Apoptosis in Oncology-" Proliferação e apoptose em oncologia" - sessão laboratorial (4h) Licenciatura em Medicina (Licenciatura)
2023/10/02 - 2023/10/02 Terapias Lipossomais em Cancro 2023 (Sistemas de Veiculação e Entrega Intracelular) Mestrado em Aplicações em Biotecnologia e Biologia Sintética (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2016 - 2020 EBV and cancer - lecture 2h mestrado integrado em medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina Dentária, Portugal
2019/10/13 - 2019/10/13 Terapias Lipossomais em Cancro - lecture 2h Aplicações em Biotecnologia e Biologia Sintética (Mestrado integrado) Universidade do Porto Faculdade de Ciências, Portugal
2001/10 - 2008/03 Biochemistry and Biophysics (chair) Nursing (Licenciatura) Escola Superior de Enfermagem de Santa Maria, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2023/01 - 2023/01 Rapporter - COST Action Monitoring and Final Assessment - CA18122 Second Progress Report Rapporteur
Evaluator
 European Cooperation in Science and Technology, Belgium European Cooperation in Science and Technology
2022/01 - 2022/01 External Expert - COST (European Cooperation in Science and Technology) Open Call (proposal nr25888)
Evaluator
 European Cooperation in Science and Technology, Belgium European Cooperation in Science and Technology
2018 - 2018 External Expert - COST (European Cooperation in Science and Technology) Open Call (proposal nr22788)
Evaluator
 European Cooperation in Science and Technology, Belgium European Cooperation in Science and Technology
2016 - 2016 External Expert - COST (European Cooperation in Science and Technology) Open Call (proposal nr21317)
Evaluator
 European Cooperation in Science and Technology, Belgium European Cooperation in Science and Technology
2016 - 2016 External Expert - COST (European Cooperation in Science and Technology) Open Call (proposal nr20760)
Evaluator
 European Cooperation in Science and Technology, Belgium European Cooperation in Science and Technology

Journal scientific committee

Journal title (ISSN) Publisher
2022/06 - Current Pharmaceuticals (1424-8247) MDPI
2020/06/25 - Current Frontiers in Molecular Biosciences ( Review Editor) (2296889X) Frontiers Media S.A.
2020/04 - Current Redox Biology (Reviewer) (ISSN: 2213-2317) Elsevier
2020/04/15 - 2021 Pharmaceuticals (Guest Editor) (1424-8247) MDPI AG

Other jury / evaluation

Activity description Institution / Organization
2021/07/07 - 2021/07/07 Examiner - Research Training Project - Biochemistry Degree Student José Miguel Teixeira Pires Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
Distinctions

Award

2021 Co author [Best Flash presentation] -III International AICC Exosome meeting- Cell to cell delivery in cancer and therapy: a matter of carriers and message
2020 Co author - 3rd PRIZE - BEST POSTER PRESENTATION (WITH SPEED TALK): CA17104 -Stratagem- New diagnostic and therapeutic tools against multidrug resistant COST WG3 meeting
2020 Co-author (2nd Best Poster Presentation Speed Talk: COST Action 17104 (STRATAGEM) WG3 Meeting - International Online Symposium on New Therapeutic Tools Against Preclinical Models of Multidrug Resistant Tumors¿