Cândida Ascensão Teixeira Tomaz (FE13-0C44-13D1)

Curriculum Vitae

Cândida Ascensão Teixeira Tomaz

Cândida Tomaz graduated in Pharmaceutical Sciences (1990) by University of Coimbra, Portugal, and completed her PhD in Biochemistry (2002) at University of Beira Interior (UBI). In 1990, she started her academic activities as Junior Teaching Assistant and since 2011 is holding the position of Associate Professor in the Chemistry Department of the Faculty of Sciences at UBI. Throughout her academic career C Tomaz has held several positions at UBI, including member of the General Council of the University, President of Sciences Faculty Council, President of Sciences Faculty Pedagogical Council and participation as a member of Coordinator Institute of Research of UBI. Additionally, she was also Vice-coordinator of Biopharmaceutical and Biomaterials Research Group and as an Executive Board member of Health Sciences Research Centre (CICS- UBI). Cândida Tomaz has played a pivotal role in education, having been the Course Director of the 1st and 2nd Cycles in Biochemistry and presently serving as the Coordinator of the Biochemistry Doctoral Program at UBI. Over the years, she has supervised almost 50 MSc and 7 PhD theses, and currently, she is supervising or co-supervising 4 PhD and 2 MSc dissertation. C Tomaz published about 60 papers in international peer reviewed journals and 8 book chapters, accumulating approximately 1200 citations. In her professional activities interacted with 243 collaborator(s) co-authorship of scientific papers. She has published in specialized and multidisciplinary high-impact scientific journals, she also serves as a member of editorial reviewer boards. In collaboration with international institutions, such as Lascaray Research Centre, University of the Basque Country and National Biotechnology Center (CSIC) at Madrid, and also with several national partners, like the University of Coimbra, University of Minho, Coimbra Institute for Clinical and Biomedical Research, and several hospitals (CHUCB, HUC, ULS Guarda, CH Leiria), Cândida Tomaz has participated in 21 research projects, mostly in the Health Biotechnology field. She served as the principal investigator in 6 projects, with 2 funded by Novartis Farma and 1 awarded by Ordem dos Farmacêuticos. Her research focus lies in downstream processing for the purification of biopharmaceuticals, particularly in the development of novel chromatographic supports, including monoliths and cryogels. Currently, she is also involved in a project aimed at developing innovative strategies for the treatment of ocular neovascular diseases. The most frequent terms in the context of scientific, technological and artistic-cultural output are: Chromatography; Plasmid DNA; DNA Vaccines; Aptamers; Proteomics; Cryogels; Monoliths; Biological Engineering and Biotechnology; Retinal Diseases; Phenolic Compounds; Egg allergy; Interactions and Bioprocess.

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Identification

Personal identification

Full name: Cândida Ascensão Teixeira Tomaz

Citation names

Tomaz, Cândida
Tomaz, C. T.

Author identifiers

Ciência ID: FE13-0C44-13D1
ORCID iD: 0000-0002-0927-2331
Google Scholar ID: https://scholar.google.pt/citations?user=aNqe4j0AAAAJ&hl=pt-PT
Researcher Id: F-9367-2014
Scopus Author Id: 7004546303

Email addresses

ctomaz@ubi.pt (Professional)
ctomaz@fcsaude.pt (Professional)

Telephones

Telephone

275319700 Ext.: 5018 (Professional)
275319762 (Professional)

Addresses

CICS-UBI-Centro Investigação em Ciências da Saúde, Universidade da Beira Interior, Rua Marquês de Àvila e Bolama, 6200-001, Covilhã, Covilhã, Portugal (Professional)
Universidade da Beira Interior, 6200-001, Covilhã, Covilhã, Portugal (Professional)

Websites

https://www.ubi.pt/Pessoa/ctomaz (Professional)

Knowledge fields

Medical and Health Sciences - Medical Biotechnology

Languages

Language	Speaking	Reading	Writing	Listening
English	Upper intermediate (B2)	Advanced (C1)	Advanced (C1)	Advanced (C1)
Spanish; Castilian	Advanced (C1)	Advanced (C1)	Upper intermediate (B2)	Advanced (C1)
French	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)

Education

	Degree	Classification
2002/09/09 Concluded	PhD in Biochemistry (Doutoramento) Universidade da Beira Interior, Portugal "Separation and Purification of Cellulases by Hydrophobic Interaction Chromatography" (THESIS/DISSERTATION)	Approved
1996/02/14 Concluded	Provas de Aptidão Pedagógica e Capacidade Científica (Outros) Universidade da Beira Interior, Portugal	Muito Bom
1990/05/30 Concluded	Ciências Farmacêuticas (Licenciatura) Universidade de Coimbra Faculdade de Farmácia, Portugal	16 valores

Affiliation

Teaching in Higher Education

	Category Host institution	Employer
2011/04/29 - Current	Associate Professor (University Teacher)	Universidade da Beira Interior, Portugal
	Universidade da Beira Interior Faculdade de Ciências, Portugal
2002/09/09 - 2011/04/29	Assistant Professor (University Teacher)	Universidade da Beira Interior, Portugal
	Universidade da Beira Interior Faculdade de Ciências, Portugal
1996/02/14 - 2002/09/09	Assistant (University Teacher)	Universidade da Beira Interior, Portugal
	Universidade da Beira Interior Faculdade de Ciências, Portugal
1990/10/21 - 1996/02/14	Trainee Assistant (University Teacher)	Universidade da Beira Interior, Portugal
	Universidade da Beira Interior Faculdade de Ciências, Portugal

Projects

Grant

	Designation	Funders
2021 - 2022	CombinatiOn aptaMer-drug Based therapeutics for ocular neovascular dIsease: wheN two are bettEr than one BINOV 2021 Principal investigator Universidade da Beira Interior, Portugal	Secção Regional do Sul e Regiões Autónomas (SRSRA), Concluded
2020 - 2021	Proteomic and Metabolomic Analysis of Vitreous Humor in Vitreoretinal Diseases Ref.14- C4 Cloud Computing Principal investigator Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	Centro de Competências em Cloud Computing (C4) Concluded

Contract

	Designation	Funders
2020 - Current	Test, Track, and Innovate in COVID-19 Diagnosis Project nº 72541- 02/SAICT/2020 - SAICT Researcher Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	Fundos Europeus Estruturais e de Investimento Ongoing
2022 - 2024/02/28	Vaginal gel for topical application in precancerous lesions caused by the HPV CENTRO-45-2021-30 Researcher Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021 - 2022	CombinatiOn aptaMer-drug Based therapeutics for ocular neovascular dIseases UIDP/Multi/00709/2020 Principal investigator Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2021 - 2021	PUREmiRSILs Ionic Liquid-based supports for pre-miRNAs purification targeting Alzheimer's disease PTDC/BII-BBF/29496/2017 Researcher Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2020/05 - 2020/10	Track and trace COVID-19 149_596826219 Research4COVID-19	Fundação para a Ciência e a Tecnologia
2020 - 2020	Track and trace COVID-19 Project 149_596826219 Researcher Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2020 - 2020	CheckImmune Project 251_596879301 Researcher Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020 - 2020	Track and trace COVID-19 Project 149_596826219	Fundação para a Ciência e a Tecnologia
2018 - 2020	C4-Cloud Computing Competence Center Centro-01-0145-FEDER-000019 Researcher Universidade da Beira Interior, Portugal	European Regional Development Fund Concluded
2019/01/01 - 2019/12/31	Health Sciences Research Centre UID/Multi/00709/2019 Universidade da Beira Interior, Portugal Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2014/12 - 2015/12	Vitreous Humor Proteomics Protocolo UBI-Novartis Farma - Produtos Farmacêuticos, SA Principal investigator	Novartis Farma - Produtos Farmacêuticos, SA Concluded
2013 - 2015	Technologies for purification and controlled release of biopharmaceuticals to be applied in age-related diseases Referência SCT_2011_02_014_2063, 2013-2015 UID/Multi/007097/2013 Researcher Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	Programa Operacional Regional do Centro - Programa “Mais Centro" Concluded
2011/03/01 - 2014/08/31	Isolation and Purification of Plasmid DNA for Cancer Therapy PTDC/EBB-BIO/114320/2009 Researcher Universidade da Beira Interior, Portugal Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2013/12/31	Strategic Project - UI 709 - 2011-2012 PEst-C/SAU/UI0709/2011 Universidade da Beira Interior, Portugal Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2011/01/01 - 2013/12/31	Projecto Estratégico - UI 195 - 2011-2012 PEst-OE/CTM/UI0195/2011 Universidade da Beira Interior, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012/05 - 2013/05	Proteomics of the vitreous humor of patients with retinal pathologies Protocolo UBI-Novartis Farma, Produtos Farmacêuticos, SA Principal investigator	Novartis Pharma GmbH Concluded
2010/09 - 2012/12	Evaluation of the therapeutic effect of thermalism in individuals with allergic rhinitis and in individuals with rheumatoid arthritis¿ ICT_2009_02_035_2031 Principal investigator Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	Programa Operacional Regional do Centro - Programa “Mais Centro" Concluded
2007/10/01 - 2010/12/31	Synthesis, optimization and intensification of bioseparation processes for DNA vaccine manufacturing PTDC/EQU-EQU/65492/2006 Researcher Universidade de Lisboa Instituto Superior Técnico, Portugal Universidade da Beira Interior, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2003/10 - 2006/12	Development of New Supports for Dye-Affinity Chromatography Provided by PTCRIS: 44776 POCTI/44776/QUI/2002 Researcher	Fundação para a Ciência e a Tecnologia, I.P.
2003 - 2005	Study of Congenital Human Cytomegalic Infection Saúde XXI Researcher Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal	Concluded
2003 - 2004	Projecto CIALE/SP6.EP19 Projecto CIALE/SP6.EP19 Researcher Universidade da Beira Interior, Portugal	Programa INTERREG III-A Concluded
2001/10 - 2003/09	Development of Hydrophobic Interaction Chromatography Supports for the Purification of Plasmid DNA for Gene Therapy Provided by PTCRIS: 43620 POCTI/43620/BIO/1999 Researcher Universidade da Beira Interior, Portugal	Fundação para a Ciência e a Tecnologia

Outputs

Publications

Book chapter	Tomaz, C. T.; Fátima Milhano dos Santos; Mesquita, Joana. "Regulation of Intraocular Oxygen by the Vitreous Gel.". In Encyclopedia of the Eye. Elsevier, 2024. In press Tomaz, Cândida T.. "Hydrophobic interaction chromatography ". In Liquid Chromatography: Fundamentals and Instrumentation, Handbooks in Separation Science, 171-190. Elsevier, 2017. Published • 10.1016/b978-0-12-805393-5.00007-5 Caramelo-Nunes, Catarina; Tomaz, Cândida T.. "Specific Recognition of Supercoiled Plasmid DNA by Affinity Chromatography Using a Synthetic Aromatic Ligand". In Methods in Molecular Biology: Affinity Chromatography Methods and Protocols, edited by Senta Reichelt, 47-54. Springer New York, 2015. Published • 10.1007/978-1-4939-2447-9_5 Tomaz, C.T.; Queiroz, J.A.. "Hydrophobic Interaction Chromatography". In Liquid Chromatography: Fundamentals and Instrumentation., edited by S. Fanali, P. Haddad, D. K. Lloyd, C.F. Poole, P.J., 121-141. Elsevier, 2013. Published • 10.1016/B978-0-12-415807-8.00006-7 C. Peixinho, P Tavares-Ratado, M. Gabriel, A. Romeira, C. Lozoya-Ibanez, L. Taborda-Barata, C.T. Tomaz, C. "Different in vivo reactivity profile in health care workers and patients with spina bifida to internal and external latex glove surface-derived allergen extracts". In World Biomedical Frontiers , Allergy. BENTHAM SCIENCE PUBLISHERS, 2013. Silva, N.; Prudencio, C.; Tomaz, C.; Fernandes, R.. "Antimicrobial susceptibility in clinical isolates of Staphylococcus aureus harbouring of mecA and lukFS-PV genes in Northern Portugal". In Science and Technology Against Microbial Pathogens: Research, Development and Evaluation, edited by A Mendez-Vilas, 275-280. World Scientific Publishing Co. Pte. Ltd, 2011. 10.1142/9789814354868_0053 C. Peixinho, P. Tavares-Ratado, M.R. Tomás, L. Taborda-Barata, C.T. Tomaz. "Latex Allergy: New Insights to Explain Different Sensitization Profiles in Different Risk Groups". In Yearbook of Dermatology and Dermatologic Surgery*. Elsevier - Health Sciences Division, 2009.
Book review	C. Peixinho, P. Tavares-Ratado, M.R. Tomás, L. Taborda-Barata, C.T. Tomaz. "Varying allergen profiles are seen on internal and external surfaces of natural rubber latex gloves". Review of Medical and Surgical Dermatology 9, (2008): 378-384. http://link.springer.com/article/10.1007%2Fs00533-008-0088-4#page-1. 10.1007/s00533-008-0088-4
Conference abstract	Ana Margarida Martins; Leithardt, Daiana; Tomaz, Cândida; António José Geraldes de Mendonça. Corresponding author: Ana Margarida Martins. "Interaction of Sodium Caseinate with Caffeic Acid by Fluorescence Spectroscopy Analysis". Paper presented in XVI Encontro de Química dos Alimentos, Castelo Branco, 2022. Published Leithardt, Daiana; Tomaz, Cândida; António José Geraldes de Mendonça. Corresponding author: Leithardt, Daiana. "Study of the interaction between lysozyme and chlorogenic acid by fluorescence spectroscopy". Paper presented in XVI Encontro de Química dos Alimentos, Castelo Branco, 2022. Published Leithardt, Daiana; Tomaz, Cândida; António José Geraldes de Mendonça. Corresponding author: Leithardt, Daiana. "Changes in the secondary structure of lysozyme after complexation with ferulic acid". Paper presented in 8th EuChemS Chemistry Congress, Lisboa, 2022. Accepted Leithardt, Daiana; Tomaz, Cândida; António José Geraldes de Mendonça. Corresponding author: Leithardt, Daiana. "Lysozyme Secondary Structure Change by Phenolic Compounds". Paper presented in XVII International CICS-UBI Symposium, Covilhã, 2022. Accepted Leithardt, Daiana; Tomaz, Cândida; António José Geraldes de Mendonça. Corresponding author: Leithardt, Daiana. "The interaction between lysozyme and chlorogenic acid: a fluorescence approach". Paper presented in XXVII National Spectroscopy Meeting (XXVII RNE) XI Iberian Spectroscopy Meeting (XI CIE), Málaga, 2022. Accepted Daiana Leithardt; Tomaz, Cândida; António José Geraldes de Mendonça. "Investigation on the Interaction of Lysozyme with Caffeic Acid by Circular Dichroism". Paper presented in 8th Latin American Symposium on Coordination and Organometallic Chemistry, Castelló, 2022. Published Leithardt, Daiana; Cândida Ascensão Teixeira Tomaz; António José Geraldes de Mendonça; Ana Margarida Martins; Tomaz, Cândida. "Changes in the Secondary Structure of Lysozyme after Complexation with Quercetin". Paper presented in XVI ANNUAL CICS-UBI SYMPOSIUM, Covilhã, 2021. Published Mesquita, Joana; Castro Sousa, Joao Paulo; Rocha, Ana S.; Santos, Fatima; Monteiro, Joao; Passarinha, Luis; Tomaz, Candida. "Quantification and comparison of VEGF-B in the vitreous of patients with diabetic ocular disease and a control group of patients with non-diabetic ocular disease". Paper presented in Annual Meeting: Association for Research in Vision and Ophthalmology, Invest Ophthalmol Vis Sci, Orlando, 2014. Published Gabriel, M. F.; Postigo, I; Gutierrez-Rodriguez, A.; Sunen, E.; Tomaz, C. T.; Martinez, J.. "Is the sensitisation to Alternaria alternata manganese-dependent superoxide dismutase a risk factor for ABPA?". Paper presented in XXXIII Congress of the European Academy of Allergy and Clinical Immunology, Copenhagen, 2014. Published Bicho, D.; Gabriel, M. F.; Tavares-Ratado, P.; Tomaz, C. T.. "Tryptase as a marker predictor in patients with monoclonal gammopathies". Paper presented in XXXII Congress of the European Academy of Allergy and Clinical Immunology , :637-707, 2013, p1941 (pg 665)., Milan, 2013. Published Gabriel, M. F.; Postigo, I; Sunen, E.; Gutierrez-Rodriguez, A.; Guisantes, J. A.; Tomaz, C. T.; Martinez, J.. "Alternaria alternata: cloning and sequence analysis of the cDNA sequence of a Asp f 6-like allergen". Paper presented in XXXII Congress of the European Academy of Allergy and Clinical Immunology, Milan, 2013. Published Gabriel, M. F.; Postigo, I; Sunen, E.; Gutierrez-Rodriguez, A.; Guisantes, J. A.; Tomaz, C. T.; Martinez, J.. "A subtilisin like serine protease of Alternaria alternata: a potentially cross-reactive allergen". Paper presented in XXXII Congress of the European Academy of Allergy and Clinical Immunology, Milan, 2013. Published Peixinho, C.; Tavares-Ratado, P.; Gabriel, M.; Lozoya-Ibanez, C.; Romeira, A.; Taborda-Barata, L.; Tomaz, C.. "Different in vivo reactivity profile in health care workers and spina bifida patients to internal and external latex glove surface-derived allergen extracts". Paper presented in XXX Congress of the European Academy of Allergy and Clinical Immunology, Istanbul, 2011. Published Gabriel, M.; Tavares-Ratado, P.; Peixinho, C.; Taborda-Barata, L.; Tomaz, C.. "Evaluation and comparison of commercially available latex extracts for skin prick tests". Paper presented in XXX Congress of the European Academy of Allergy and Clinical Immunology 320–481, 2011, p 822 (pag 321)., Istanbul, 2011. Published Peixinho, C; Tavares-Ratado, P; Gabriel, M; Araujo, L; Taborda-Barata, L; Tomaz, C.. "Analysis of specific IgE reactivity profiles in latex sensitised patients by using internal and external glove extracts as solid phase". Paper presented in XXIX EAACI Congress of the European Academy of Allergy and Clinical Immunology, London, 2010. Published • 10.1111/j.1398-9995.2010.02392.x Tavares-Ratado, P.; Domingos, A.; Costa, M.; Taborda-Barata, L.; Tomaz, C.. "Microarray analysis of latex sensitisation profiles in Portuguese blood donors". Paper presented in XXIX EAACI Congress of the European Academy of Allergy and Clinical Immunology, London, 2010. Published C. Peixinho, P. Tavares-Ratado, L. Taborda-Barata, C.T. Tomaz. "Enriched fractions of gloves latex allergens for laboratorial diagnosis of latex allergy". Paper presented in XXVIII Congress of the European Academy of Allergology and Clinical Immunology (EAACI), Warsow, 2009. Published • DOI: 10.1111/j.1398-9995.2009.02076.x Fonseca, P.; Tavares-Ratado, P.; Tomaz, C.. "Sensitised pattern characterisation in mite allergic patients". Paper presented in XXVIII Congress of the European Academy of Allergology and Clinical Immunology (EAACI), Warsow, 2009. Published • 10.1111/j.1398-9995.2009.02076.x Tavares-Ratado, P.; Domingos, A.; Costa, M.; Taborda-Barata, L.; Tomaz, C.. "Prevalence of latex sensitisation in Portuguese blood donors". Paper presented in XXVIII Congress of the European Academy of Allergology and Clinical Immunology (EAACI) Suppl. 90, Warsow, 2009. Published • 10.1111/j.1398-9995.2009.02076.x C. Peixinho, P. Tavares-Ratado, M.R. Tomás, L. Taborda-Barata, C.T. Tomaz. "Latex Alergy: new insights to explain different sensitization profiles in different risk groups". Paper presented in XXVII Congress of the European Academy of Allergology and Clinical Immunology (EAACI), Barcelona, 2008. Published • 10.1111/j.1398-9995.2008.01759.x Tomaz, C. T.. "Interference study of Dermatophagoides’ specific immunoglobulins G in the quantification of mite’s specific immunoglobulins E". Paper presented in XXVII Congress of the European Academy of Allergology and Clinical Immunology (EAACI), Barcelona, 2008. Published • 10.1111/j.1398-9995.2008.01760.x Tavares, P.M.; Peixinho, C.M.A.; Tomás, M.R.T.; Taborda-Barata, L.M.P.; Tomaz, C.A.T.. "Expression of Latex Allergens on Inner and Outer Surfaces of Latex Surgical Gloves". Paper presented in American Academy of Allergy Asthma & Immunology (AAAAI), 62nd Annual Meeting, Journal of Allergy and Clinical Immunology, Miami, 2006. Published • 10.1016/j.jaci.2005.12.099 F. Sousa, C. T. Tomaz, D. M. F. Prazeres, J. A. Queiroz. "Separation of Supercoiled and Open Circular Plasmid DNA Isoforms by Chromatography with a Histidine-Agarose Support". Paper presented in European Congress on Biotechnology, Journal of Biotechnology, Copenhagen, 2005. Published • 10.1016/s0168-1656(01)00237-1
Conference paper	Fátima Milhano dos Santos; Gaspar, Leonor M.; Albuquerque, Tânia Gonçalves; João ML Dias; João Paulo Castro de Sousa; Alberto Paradela; Tomaz, Cândida; Passarinha, Luís. "Improvement of bidimensional electrophoretic conditions for vitreous protein analysis using an artificial neural network.". Paper presented in 12th European Symposium on Biochemical Engineering Science, 2018. Mesquita, Joana; Castro de Sousa, Joao Paulo; Vaz-Pereira, Sara; Neves, Arminda; Passarinha, Luis; Tomaz, Candida. "Quantitative research of VEGF-A, VEGF-B and PIGF in vitreous and serum in angiogenic ocular disorders". Paper presented in Annual Meeting: Association for Research in Vision and Ophthalmology, ARVO Meeting Abstracts, 2018, Honolulu, 2018. Published Mesquita, Joana; Castro e Sousa, Joao Paulo; Vaz-Pereira, Sara; Neves, Arminda; Passarinha, Luis; Tomaz, Candida. "Quantitative analysis and correlation of VEGF-A and VEGF-B in serum and vitreous humor of patients with proliferative vs non-proliferative ocular disease". Paper presented in Annual Meeting: Association for Research in Vision and Ophthalmology, ARVO, Baltimore, 2017. Published Mesquita, Joana; Castro Sousa, Joao Paulo; Vaz-Pereira, Sara; Neves, Arminda; Tavares-Ratado, Paulo; Passarinha, Luis; Tomaz, Candida. "Correlation between concentration of vitreous angiogenic cytokines (VEGF-B and PIGF) with central retinal thickness and macular volume in diabetic retinopathy patients". Paper presented in Annual Meeting: Association for Research in Vision and Ophthalmology, ARVO, Seattle, 2016. Published Mesquita, Joana; Castro Sousa, Joao Paulo; Tavares-Ratado, Paulo; Vaz-Pereira, Sara; Neves, Arminda; Rocha, Ana S.; Santos, Fatima; Passarinha, Luis; Tomaz, Candida. "Comparison of serum and vitreous PIGF in diabetic retinopathy patients and nondiabetic patients". Paper presented in Association for Research in Vision and Ophthalmology, ARVO Meeting, Denver, 2015. Bicho, D.; Caramlo-Nunes, C.; Santos, B. F.; Sousa, A.; Sousa, F.; Queiroz, J. A.; Tomaz, C. T.. "Amino acid derivatized monoliths for purification of a DNA vaccine against influenza". Paper presented in 2015 IEEE 4th Portuguese Meeting on Bioengineering (ENBENG), Oporto, 2015. Published • 10.1109/enbeng.2015.7088803 Gabriel, M.; Postigo, I; Gutierrez-Rodriguez, A.; Sunen, E.; Tomaz, C.; Martinez, J.. "Development of a based-gene encoding allergen tool for detecting Alt a 1 and Alt a 1 homologues". Paper presented in XXXIV Congress of the European Academy of Allergy and Clinical Immunology, Barcelona, 2015. Published Gabriel, M.; Postigo, I; Gutierrez-Rodriguez, A.; Sunen, E.; Guisantes, J. A.; Fernandez, J.; Tomaz, C.; Martinez, J.. "Cloning and characterisation of Alt a 15, a novel cross-reactive allergen from Alternaria alternata". Paper presented in XXXIV Congress of the European Academy of Allergy and Clinical Immunology, Barcelona, 2015. Published
Conference poster	Moreira, David; Leitão, Daniela; Lopes-Nunes, Jéssica; Santos, Tiago; Figueiredo, Joana; Miranda, André; Alexandre, Daniela; et al. "DECODING AT11-L2: G-QUADRUPLEX STRUCTURE, STABILITY, AND INTERACTION WITH LIGANDS AND NUCLEOLIN". Paper presented in XVIII International CICS-UBI Symposium, 2023. Moreira, David; Leitão, Daniela; Lopes-Nunes, Jéssica; Santos, Tiago; Figueiredo, Joana; Miranda, André; Alexandre, Daniela; et al. "G-quadruplex aptamer interactions with ligands and nucleolin". Paper presented in INTERACTION WINS 2023 (virtual), 2023. Boto, Renato; Tomaz, Cândida. "POLYTHYMINE CRYOGELS FOR SELECTIVE mRNA PURIFICATION". Paper presented in Biopartition & Purification Conference, 2022. Moreira, David; Lopes-Nunes, Jéssica; Fátima Milhano dos Santos; Cruz, Carla; Tomaz, C. T.. Corresponding author: Tomaz, C. T.. "Aptamero anti-nucleolina para o desenvolvimento de nanopartículas para terapia do retinoblastoma". Paper presented in 4º ENCONTRO NACIONAL DE JOVENS INVESTIGADORES EM ONCOLOGIA, 2022. Moreira, David; Lopes-Nunes, Jéssica; Fátima Milhano dos Santos; Cruz, Carla; Tomaz, Cândida. Corresponding author: Tomaz, Cândida. "Aptamero anti-nucleolina no tratamento de doenças neovasculares da retina". Paper presented in VIII Ciclo de Conferências da Faculdade de Ciências, 2022. Leitão, Daniela; Moreira, David; Figueiredo, Joana; Santos, Tiago; Tomaz, C. T.; Cruz, Carla. Corresponding author: Cruz, Carla. "Ligand screening to stabilize a DNA aptamer". Paper presented in XVII International CICS-UBI Symposium, 2022. Raposo, Joana; Feijó, Mariana; Maia, Cláudio J. B.; Socorro, Sílvia; Tomaz, Cândida; Correia, Sara. "Efeito do desregulador endócrino metoxicloro em células espermatogoniais". Paper presented in XVI Reunião Ibérica de Andrologia, Medicina Sexual e Reprodução, Évora, 2022. Raposo, Joana; Feijó, Mariana; Maia, Cláudio J. B.; Socorro, Sílvia; Tomaz, Cândida; Correia, Sara. "The impact of the endocrine disruptor methoxychlor on spermatogonial survival". Paper presented in XVII International CICS-UBI Symposium, Covilhã, 2022. Simões, Pedro; Lopes-Nunes, Jéssica; Tomaz, Cândida; Cruz, Carla. "Development of RNA Functionalized Nanoparticle for Oral Cancer Therapy". Paper presented in UT Austin Portugal 2021 Annual Conference, 2021. David Moreira; Lopes-Nunes, Jéssica; Santos, Fátima; Cruz, Carla; Tomaz, Cândida. "DEVELOPMENT OF APTAMER NANOPARTICLES FOR TREATMENT OF RETINAL DISEASES". Paper presented in XVI CICS-UBI Symposium, 2021. Simões, Pedro; Lopes-Nunes, Jéssica; Tomaz, Cândida; Cruz, Carla. "DEVELOPMENT OF RNA FUNCTIONALIZED NANOPATICLE FOR ORAL CANCER THERAPY". Paper presented in XVI CICS-UBI Symposium, 2021. Leithardt, Daiana; Tomaz, Cândida; MENDONÇA, ANTÓNIO. "Changes in the tertiary structure of lysozyme by interactions with phenolic compounds". Paper presented in XV Annual CICS-UBI Symposium, 2020. Martins, A.M.; Tomaz, C. T.; MENDONÇA, ANTÓNIO. "Interaction of phenolic compounds with sodium caseinate". Paper presented in XV Annual CICS-UBI Symposium, 2020. Santos, F.M.; Ciordia, Sergio; Paradela, Alberto; Castro-de-Sousa, João P.; Garcia-Flores, Marta; Cruz, Carla; Tomaz, Cândida; Passarinha, Luís. "Label-Free Relative Quantification For Vitreous Proteome Profiling In Age-Related Macular Degeneration And Diabetic Retinopathy.". Paper presented in III International Congress in Health Sciences Research towards innovation and entrepreneurship, 2019. Santos, F.M.; Ciordia, Sergio; Paradela, Alberto; Castro-de-Sousa, João P.; Garcia-Flores, Marta; Cruz, Carla; Tomaz, Cândida; Passarinha, Luís. "Vitreous proteome profiling in age-related macular degeneration and diabetic retinopathy.". Paper presented in XIV Annual Symposium CICS-UBI, 2019. 10.1109/iccp.2018.8516635 Vapor, A.W.; Tomaz, C. T.; MENDONÇA, ANTÓNIO; Vapor, Alcides; Tomaz, Cândida T.; Mendonça, António. "Interactions of Phenolic Compounds with Ovalbumin.". Paper presented in XX Eurofood Chem, 2019. Santos, Tiago; Brito, Andreia; Boto, Renato; Sousa, Pedro; Almeida, Paulo; Cruz, Carla; Tomaz, Cândida. "Purification of Influenza DNA vaccine using pHEMA cryogel support". Paper presented in ESBES 2018, 2018. Santos, Tiago; Brito, Andreia; Boto, Renato; Sousa, Pedro; Almeida, Paulo; Cruz, Carla; Tomaz, Cândida. "Purification of Influenza DNA vaccine by a pHEMA cryogel support". Paper presented in XIII Annual CICS-UBI symposium 2018, 2018. Fátima Milhano dos Santos; Gaspar, Leonor M.; Sergio Ciordia; Sousa, João; Alberto Paradela; Passarinha, Luís; Tomaz, Cândida. "Characterization of proteome of vitreous humor in retinal detachment using different experimental setups.". Paper presented in 16th Human Proteome Organisation World Congress, 2017. Santos, Tiago; Proença, Zélia; Queiroz, João A.; Tomaz, Cândida; Cruz, Carla. "Plasmid DNA purification using a naphthalene tripodal support". Paper presented in XII Annual CICS-UBI symposium 2017, 2017. Fátima Milhano dos Santos; Gaspar, Leonor M.; Sergio Ciordia; João Paulo Castro de Sousa; Alberto Paradela; Passarinha, Luís; Tomaz, Cândida. "Proteome of vitreous humor in retinal detachment.". Paper presented in XII Annual CICS Symposium, 2017. Gaspar, Leonor M.; Fátima Milhano dos Santos; Albuquerque, Tânia Gonçalves; João Paulo Castro de Sousa; Passarinha, Luís; Tomaz, Cândida. "Proteomic analysis of vitreous humor samples in retinal detachment.". Paper presented in 5th Cycle of Conferences of the Faculty of Sciences, 2017. Fátima Milhano dos Santos; Gaspar, Leonor M.; Sergio Ciordia; Sousa, João; Alberto Paradela; Passarinha, Luís; Tomaz, Cândida. "ITRAQ quantitative analysis of vitreous in Proliferative Diabetic Retinopathy.". Paper presented in Dia da Ciência, 2017. Fátima Milhano dos Santos; Gaspar, Leonor M.; Albuquerque, Tânia; João ML Dias; Sousa, João; Alberto Paradela; Tomaz, Cândida; Passarinha, Luís. "Enhancement of bidimensionalelectrophoretic operation conditions by an artificial neural network for vitreous humor protein analysis". Paper presented in International Congress onAnalytical Proteomics, 2017. Gaspar, Leonor M.; Fátima Milhano dos Santos; Sousa, João; Passarinha, Luís; Tomaz, Cândida. "Proteomic analysis of the human vitreous humor in retinal detachment". Paper presented in IV International Conference on Analytical Proteomics, 2015. Fátima Milhano dos Santos; Gaspar, Leonor M.; Ana Sílvia Rocha; Sergio Ciordia; Sousa, João; Alberto Paradela; Passarinha, Luís; Tomaz, Cândida. "iTRAQ quantitative proteomics in analysis of vitreous humor from patients with retinal detachment". Paper presented in IV International Conference on Analytical Proteomics, 2015. Peixinho, C.; Tavares-Ratado, P.; Tomás, M.R.; Taborda-Barata, L.; Tomaz, C.. "Latex allergy: new insights to explain different sensitisation profiles in different risk groups". Paper presented in XXVII Congress of the European Academy of Allergology and Clinical Immunology (EAACI), Barcelona, Spain, 2008.
Journal article	Lopes-Nunes, Jéssica; Simões, Pedro; Moreira, David; Leandro, Kevin; Nobre, Rui Jorge; Pereira de Almeida, Luís; Campello, Maria Paula Cabral; et al. "RNA-based liposomes for oral cancer: From biophysical characterization to biological evaluation". International Journal of Biological Macromolecules 259 (2024): 129157. http://dx.doi.org/10.1016/j.ijbiomac.2023.129157. Published • 10.1016/j.ijbiomac.2023.129157 Sílvia Martins; Natália António; Ricardo Rodrigues; Tiago Carvalheiro; Cândida Tomaz; Lino Gonçalves; Artur Paiva. "Role of monocytes and dendritic cells in cardiac reverse remodelling after cardiac resynchronization therapy". BMC Cardiovascular Disorders (2023): https://doi.org/10.1186/s12872-023-03574-4. 10.1186/s12872-023-03574-4 David Moreira; Jéssica Lopes-Nunes; Fátima Milhano Santos; Maria Paula Cabral Campello; Maria Cristina Oliveira; António Paulo; Cândida Tomaz; Carla Cruz. "Assessment of Aptamer as a Potential Drug Targeted Delivery for Retinal Angiogenesis Inhibition". Pharmaceuticals (2023): https://doi.org/10.3390/ph16050751. 10.3390/ph16050751 Santos, Fátima M.; Ciordia, Sergio; Mesquita, Joana; Cruz, Carla; Sousa, João Paulo Castro e; Passarinha, Luís A.; Tomaz, Cândida T.; Paradela, Alberto. "Proteomics profiling of vitreous humor reveals complement and coagulation components, adhesion factors, and neurodegeneration markers as discriminatory biomarkers of vitreoretinal eye diseases". Frontiers in Immunology 14 (2023): http://dx.doi.org/10.3389/fimmu.2023.1107295. Open access • Published • 10.3389/fimmu.2023.1107295 Martins, Sílvia; António, Natália; Carvalheiro, Tiago; Laranjeira, Paula; Rodrigues, Ricardo; Gonçalves, Lino; Tomaz, Cândida; Paiva, Artur. "Reduced numbers of regulatory T cells in chronic heart failure seems not to be restored by cardiac resynchronization therapy". BMC Cardiovascular Disorders 23 1 (2023): http://dx.doi.org/10.1186/s12872-023-03109-x. Open access • Published • 10.1186/s12872-023-03109-x dos Santos, Fátima Milhano; Ciordia, Sergio; Mesquita, Joana; de Sousa, João Paulo Castro; Paradela, Alberto; Tomaz, Cândida Teixeira; Passarinha, Luís António Paulino. "Vitreous humor proteome: unraveling the molecular mechanisms underlying proliferative and neovascular vitreoretinal diseases". Cellular and Molecular Life Sciences 80 1 (2022): http://dx.doi.org/10.1007/s00018-022-04670-y. Published • 10.1007/s00018-022-04670-y Moreira, David; Leitão, Daniela; Lopes-Nunes, Jéssica; Santos, Tiago; Figueiredo, Joana; Miranda, André; Alexandre, Daniela; et al. "G-Quadruplex Aptamer-Ligand Characterization". Molecules 27 20 (2022): 6781. http://dx.doi.org/10.3390/molecules27206781. Open access • Published • 10.3390/molecules27206781 Santos, Fátima Milhano; Mesquita, Joana; Castro-de-Sousa, João Paulo; Ciordia, Sergio; Paradela, Alberto; Tomaz, Cândida Teixeira. "Vitreous Humor Proteome: Targeting Oxidative Stress, Inflammation, and Neurodegeneration in Vitreoretinal Diseases". Antioxidants 11 3 (2022): 505. http://dx.doi.org/10.3390/antiox11030505. Open access • 10.3390/antiox11030505 Vapor, Alcides; Mendonça, António; Tomaz, Cândida T.. "Processes for reducing egg allergenicity: Advances and different approaches". Food Chemistry 367 (2022): 130568. http://dx.doi.org/10.1016/j.foodchem.2021.130568. Published • 10.1016/j.foodchem.2021.130568 Carvalho, Josué; Lopes-Nunes, Jéssica; Figueiredo, Joana; Santos, Tiago; Miranda, André; Riscado, Micaela; Sousa, Fani; et al. "Molecular Beacon Assay Development for Severe Acute Respiratory Syndrome Coronavirus 2 Detection". Sensors 21 21 (2021): 7015. http://dx.doi.org/10.3390/s21217015. Open access • Published • 10.3390/s21217015 Oliveira, Cátia; Amador, Paula; Prudêncio, Cristina; Tomaz, Cândida T; Tavares-Ratado, Paulo; Fernandes, Rúben. "ESBL and AmpC ß-Lactamases in Clinical Strains of Escherichia coli from Serra da Estrela, Portugal". Medicina 55 6 (2019): 272. http://dx.doi.org/10.3390/medicina55060272. 10.3390/medicina55060272 Santos, Fátima M.; Albuquerque, Tânia; Gaspar, Leonor M.; Dias, João M. L.; Castro e Sousa, João P.; Paradela, Alberto; Tomaz, Cândida T.; Passarinha, Luís A.. "Refinement of two-dimensional electrophoresis for vitreous proteome profiling using an artificial neural network". Analytical and Bioanalytical Chemistry 411 20 (2019): 5115-5126. http://dx.doi.org/10.1007/s00216-019-01887-y. 10.1007/s00216-019-01887-y Martins, Sílvia; Carvalheiro, Tiago; Laranjeira, Paula; Martinho, António; Elvas, Luís; Gonçalves, Lino; Tomaz, Cândida; António, Natália; Paiva, Artur. "Impact of cardiac resynchronization therapy on circulating IL-17 producing cells in patients with advanced heart failure". Journal of Interventional Cardiac Electrophysiology 54 3 (2019): 257-265. http://dx.doi.org/10.1007/s10840-018-0491-3. 10.1007/s10840-018-0491-3 Santos, Tiago; Brito, Andreia; Boto, Renato; Sousa, Pedro; Almeida, Paulo; Cruz, Carla; Tomaz, Cândida. "Influenza DNA vaccine purification using pHEMA cryogel support". Separation and Purification Technology 206 (2018): 192-198. http://dx.doi.org/10.1016/j.seppur.2018.06.002. 10.1016/j.seppur.2018.06.002 Gaspar, C.; Donders, G. G.; Palmeira-de-Oliveira, R.; Queiroz, J. A.; Tomaz, C.; Martinez-de-Oliveira, J.; Palmeira-de-Oliveira, A.. "Bacteriocin production of the probiotic Lactobacillus acidophilus KS400". AMB Express 8 1 (2018): 153. http://dx.doi.org/10.1186/s13568-018-0679-z. Open access • Published • 10.1186/s13568-018-0679-z Santos, Fátima; Gaspar, Leonor; Ciordia, Sergio; Rocha, Ana; Castro e Sousa, João; Paradela, Alberto; Passarinha, Luís; Tomaz, Cândida. "iTRAQ Quantitative Proteomic Analysis of Vitreous from Patients with Retinal Detachment". International Journal of Molecular Sciences 19 4 (2018): 1157. http://dx.doi.org/10.3390/ijms19041157. Open access • Published • 10.3390/ijms19041157 Mesquita, Joana; Castro-de-Sousa, João Paulo; Vaz-Pereira, Sara; Neves, Arminda; Passarinha, Luís A.; Tomaz, Cândida T.. "Evaluation of the growth factors VEGF-a and VEGF-B in the vitreous and serum of patients with macular and retinal vascular diseases". Growth Factors 36 1-2 (2018): 48-57. http://dx.doi.org/10.1080/08977194.2018.1477140. Published • 10.1080/08977194.2018.1477140 Mesquita, Joana; Castro-de-Sousa, João Paulo; Vaz-Pereira, Sara; Neves, Arminda; Passarinha, Luís A.; Tomaz, Cândida T.. "Vascular endothelial growth factors and placenta growth factor in retinal vasculopathies: Current research and future perspectives". Cytokine & Growth Factor Reviews 39 (2018): 102-115. http://dx.doi.org/10.1016/j.cytogfr.2017.11.005. Published • 10.1016/j.cytogfr.2017.11.005 Santos, T.; Proença, Z.; Queiroz, J.A.; Tomaz, C.; Cruz, C.. "Plasmid purification by using a new naphthalene tripodal support". Separation and Purification Technology 188 (2017): 81-89. http://dx.doi.org/10.1016/j.seppur.2017.06.072. Published • 10.1016/j.seppur.2017.06.072 Gaspar, Leonor M.; Santos, Fátima M.; Albuquerque, Tânia; Castro-de-Sousa, João P.; Passarinha, Luís A.; Tomaz, Cândida T.. "Proteome analysis of vitreous humor in retinal detachment using two different flow-charts for protein fractionation". Journal of Chromatography B 1061-1062 (2017): 334-341. http://dx.doi.org/10.1016/j.jchromb.2017.07.049. Published • 10.1016/j.jchromb.2017.07.049 Mesquita, Joana; Castro de Sousa, João; Vaz-Pereira, Sara; Neves, Arminda; Tavares-Ratado, Paulo; M. Santos, Fátima; A. Passarinha, Luís; T. Tomaz, Cândida. "VEGF-B Levels in the Vitreous of Diabetic and Non-Diabetic Patients with Ocular Diseases and Its Correlation with Structural Parameters". Medical Sciences 5 3 (2017): 17. http://dx.doi.org/10.3390/medsci5030017. 10.3390/medsci5030017 Gabriel, Marta F.; Postigo, Idoia; Tomaz, Cândida T.; Martínez, Jorge. "Alternaria alternata allergens: Markers of exposure, phylogeny and risk of fungi-induced respiratory allergy". Environment International 89-90 (2016): 71-80. http://dx.doi.org/10.1016/j.envint.2016.01.003. Published • 10.1016/j.envint.2016.01.003 Bicho, D.; Caramelo-Nunes, C.; Sousa, A.; Sousa, F.; Queiroz, J.A.; Tomaz, C.T.. "Purification of influenza deoxyribonucleic acid-based vaccine using agmatine monolith". Journal of Chromatography B 1012-1013 (2016): 153-161. http://dx.doi.org/10.1016/j.jchromb.2015.12.036. Published • 10.1016/j.jchromb.2015.12.036 Gabriel, M.F.; Postigo, I.; Gutiérrez-Rodríguez, A.; Suñén, E.; Guisantes, J.A.; Fernández, J.; Tomaz, C.T.; Martínez, J.. "Alt a 15 is a new cross-reactive minor allergen of Alternaria alternata". Immunobiology 221 2 (2016): 153-160. http://dx.doi.org/10.1016/j.imbio.2015.09.014. Published • 10.1016/j.imbio.2015.09.014 Bicho, Diana; Queiroz, Joao; Tomaz, Candida. "Influenza Plasmid DNA Vaccines: Progress and Prospects". Current Gene Therapy 15 6 (2015): 541-549. http://dx.doi.org/10.2174/1566523215666150929111048. Published • 10.2174/1566523215666150929111048 Bicho, D.; Santos, B.F.; Caramelo-Nunes, C.; Sousa, A.; Sousa, F.; Queiroz, J.A.; Tomaz, C.T.. "Application of ethylenediamine monolith to purify a hemagglutinin influenza deoxyribonucleic acid-based vaccine". Separation and Purification Technology 154 (2015): 320-327. http://dx.doi.org/10.1016/j.seppur.2015.09.046. Published • 10.1016/j.seppur.2015.09.046 Bicho D; Queiroz JA; Tomaz CT. "Influenza plasmid DNA vaccines: progress and prospects.". (2015): http://europepmc.org/abstract/med/26415574. Gabriel, Marta F.; Postigo, Idoia; Gutiérrez-Rodríguez, Antonio; Suñén, Ester; Guisantes, Jorge; Tomaz, Cândida T.; Martínez, Jorge. "Characterisation of Alternaria alternata manganese-dependent superoxide dismutase, a cross-reactive allergen homologue to Asp f 6". Immunobiology 220 7 (2015): 851-858. http://dx.doi.org/10.1016/j.imbio.2015.01.006. Published • 10.1016/j.imbio.2015.01.006 Gabriel, M. F.; Postigo, I.; Gutiérrez-Rodríguez, A.; Suñén, E.; Tomaz, C. T.; Martínez, J.. "Development of a PCR-based tool for detecting immunologically relevant Alt a 1 and Alt a 1 homologue coding sequences". Medical Mycology 53 6 (2015): 636-642. http://dx.doi.org/10.1093/mmy/myv022. Published • 10.1093/mmy/myv022 Monteiro, João P.; Santos, Fátima M.; Rocha, Ana S.; Castro-de-Sousa, João P.; Queiroz, João A.; Passarinha, Luis A.; Tomaz, Cândida T.. "Vitreous humor in the pathologic scope: Insights from proteomic approaches". PROTEOMICS - Clinical Applications 9 1-2 (2015): 187-202. http://dx.doi.org/10.1002/prca.201400133. Published • 10.1002/prca.201400133 C. Caramelo-Nunes, C.T. Tomaz. "Specific recognition of supercoiled plasmid DNA by affinity chromatography using a synthetic aromatic ligand". Methods in Molecular Biology 128647 (2015): 10.1007/978-1-4939-2447-9_5 Rocha, Ana S.; Santos, Fátima M.; Monteiro, João P.; Castro-de-Sousa, João P.; Queiroz, João A.; Tomaz, Cândida T.; Passarinha, Luís A.. "Trends in proteomic analysis of human vitreous humor samples". ELECTROPHORESIS 35 17 (2014): 2495-2508. http://dx.doi.org/10.1002/elps.201400049. Published • 10.1002/elps.201400049 Bicho, Diana; Sousa, Ângela; Sousa, Fani; Queiroz, João; Tomaz, Cãndida. "Effect of chromatographic conditions and plasmid DNA size on the dynamic binding capacity of a monolithic support". Journal of Separation Science 37 17 (2014): 2284-2292. http://dx.doi.org/10.1002/jssc.201400127. 10.1002/jssc.201400127 Peixinho, C.M.; Gabriel, M.F.; Caramelo-Nunes, C.; Tavares-Ratado, P.; Tomaz, C.T.. "Separation of the four most important latex allergens from latex gloves: A potential tool for diagnosis and immunotherapy purposes". Allergologia et Immunopathologia 42 4 (2014): 380-383. http://dx.doi.org/10.1016/j.aller.2013.03.003. Published • 10.1016/j.aller.2013.03.003 Caramelo-Nunes, C.; Gabriel, M.F.; Almeida, P.; Marcos, J.C.; Tomaz, C.T.. "Negative pseudo-affinity chromatography for plasmid DNA purification using berenil as ligand". Journal of Chromatography B 944 (2014): 39-42. http://dx.doi.org/10.1016/j.jchromb.2013.10.043. Published • 10.1016/j.jchromb.2013.10.043 Caramelo-Nunes, C.; Almeida, P.; Marcos, J.C.; Tomaz, C.T.. "Aromatic ligands for plasmid deoxyribonucleic acid chromatographic analysis and purification: An overview". Journal of Chromatography A 1327 (2014): 1-13. http://dx.doi.org/10.1016/j.chroma.2013.12.057. Published • 10.1016/j.chroma.2013.12.057 H. Pereira, C. Tomaz, J. Cavaco, P. Tavares-Ratado. "Personality and Levels of Cholesterol and Glucose". Journal of Nutrition & Food Sciences 04 05 (2014): 291. http://dx.doi.org/10.4172/2155-9600.1000291. 10.4172/2155-9600.1000291 Caramelo-Nunes, C.; Bicho, D.; Almeida, P.; Marcos, J.C.; Tomaz, C.T.. "Dynamic binding capacity and specificity of 3,8-diamino-6-phenylphenanthridine-Sepharose support for purification of supercoiled plasmid deoxyribonucleic acid". Journal of Chromatography A 1307 (2013): 91-98. http://dx.doi.org/10.1016/j.chroma.2013.07.078. Published • 10.1016/j.chroma.2013.07.078 Caramelo-Nunes, C.; Almeida, P.; Marcos, J.C.; Tomaz, C.T.. "Specific recognition of supercoiled plasmid DNA by affinity chromatography using the intercalator DAPP as ligand". Journal of Chromatography B 928 (2013): 121-124. http://dx.doi.org/10.1016/j.jchromb.2013.04.001. Published • 10.1016/j.jchromb.2013.04.001 Mota, Élia; Sousa, Ângela; Cernigoj, Urh; Queiroz, João A.; Tomaz, Cândida T.; Sousa, Fani. "Rapid quantification of supercoiled plasmid deoxyribonucleic acid using a monolithic ion exchanger". Journal of Chromatography A 1291 (2013): 114-121. http://dx.doi.org/10.1016/j.chroma.2013.03.070. Published • 10.1016/j.chroma.2013.03.070 Gabriel MF; Tavares-Ratado P; Peixinho CM; Romeira AM; Taborda-Barata L; Postigo I; Martínez J; Tomaz CT. "Evaluation and comparison of commercially available latex extracts for skin prick tests". Journal of Investigational Allergology and Clinical Immunology 23 7 (2013): 478-486. https://publons.com/publon/2535724/. Published Caramelo-Nunes, C.; Gabriel, M.F.; Almeida, P.; Marcos, J.C.; Tomaz, C.T.. "Purification of plasmid DNA from clarified and non-clarified Escherichia coli lysates by berenil pseudo-affinity chromatography". Journal of Chromatography B 904 (2012): 81-87. http://dx.doi.org/10.1016/j.jchromb.2012.07.023. Published • 10.1016/j.jchromb.2012.07.023 Peixinho, C.M.; Tavares-Ratado, P.; Gabriel, M.F.; Romeira, A.M.; Lozoya-Ibanez, C.; Taborda-Barata, L.; Tomaz, C.T.. "Different in vivo reactivity profile in health care workers and patients with spina bifida to internal and external latex glove surface-derived allergen extracts". British Journal of Dermatology 166 3 (2012): 518-524. http://dx.doi.org/10.1111/j.1365-2133.2011.10656.x. 10.1111/j.1365-2133.2011.10656.x Sousa, A.; Tomaz, C.T.; Sousa, F.; Queiroz, J.A.. "Successful application of monolithic innovative technology using a carbonyldiimidazole disk to purify supercoiled plasmid DNA suitable for pharmaceutical applications". Journal of Chromatography A 1218 46 (2011): 8333-8343. http://dx.doi.org/10.1016/j.chroma.2011.09.033. Published • 10.1016/j.chroma.2011.09.033 Caramelo-Nunes, C.; Tente, T.; Almeida, P.; Marcos, J.C.; Tomaz, C.T.. "Specific berenil–DNA interactions: An approach for separation of plasmid isoforms by pseudo-affinity chromatography". Analytical Biochemistry 412 2 (2011): 153-158. http://dx.doi.org/10.1016/j.ab.2011.01.033. Published • 10.1016/j.ab.2011.01.033 Sousa, A.; Bicho, D.; Tomaz, C.T.; Sousa, F.; Queiroz, J.A.. "Performance of a non-grafted monolithic support for purification of supercoiled plasmid DNA". Journal of Chromatography A 1218 13 (2011): 1701-1706. http://dx.doi.org/10.1016/j.chroma.2010.12.018. Published • 10.1016/j.chroma.2010.12.018 Amaral, C.; Gallardo, E.; Rodrigues, R.; Pinto Leite, R.; Quelhas, D.; Tomaz, C.; Cardoso, M.L.. "Quantitative analysis of five sterols in amniotic fluid by GC–MS: Application to the diagnosis of cholesterol biosynthesis defects". Journal of Chromatography B 878 23 (2010): 2130-2136. http://dx.doi.org/10.1016/j.jchromb.2010.06.010. Published • 10.1016/j.jchromb.2010.06.010 Peixinho, C.; Tavares-Ratado, P.; Gabriel, M.; Araujo, L.; Taborda-Barata, L.; Tomaz, C.. "Analysis of specific IgE reactivity profiles in latex sensitised patients by using internal and external glove extracts as solid phase". Allergy (2010): https://publons.com/publon/27371336/. Silva, A.; Boto, R.E.F.; Tomaz, C.T.; Queiroz, J.A.; Almeida, P.. "Rhodamine B as ligand for affinity chromatography: Chromatographic studies on derivatized beaded cellulose". Journal of Chromatographic Science 48 3 (2010): 240-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949310368&partnerID=MN8TOARS. Fonseca, Patrícia; Tavares-Ratado, Paulo; Tomaz, Cândida T.. "Interference of Dermatophagoides' Specific Immunoglobulins G in the Quantification of Mite's Specific Immunoglobulins E". Journal of Immunoassay and Immunochemistry 30 3 (2009): 338-347. http://dx.doi.org/10.1080/15321810903084814. 10.1080/15321810903084814 Peixinho, C.; Tavares-Ratado, P.; Taborda-Barata, L.; Tomaz, C.. "Enriched fractions of glove latex allergens for laboratorial diagnosis of latex allergy". Allergy (2009): https://publons.com/publon/27371340/. Peixinho, C.; Tavares-Ratado, P.; Tomás, M.R.; Taborda-Barata, L.; Tomaz, C.T.. "Latex allergy: new insights to explain different sensitization profiles in different risk groups". British Journal of Dermatology 159 1 (2008): 132-136. http://dx.doi.org/10.1111/j.1365-2133.2008.08614.x. 10.1111/j.1365-2133.2008.08614.x Peixinho, C.; Tavares, P.; Tomáz, M.R.; Taborda-Barata, L.; Tomáz, C.. "Differential expression of allergens on the internal and external surfaces of latex surgical gloves". Allergologia et Immunopathologia 34 5 (2006): 206-211. http://dx.doi.org/10.1157/13094028. 10.1157/13094028 Sousa, F.; Tomaz, C.T.; Prazeres, D.M.F.; Queiroz, J.A.. "Separation of supercoiled and open circular plasmid DNA isoforms by chromatography with a histidine–agarose support". Analytical Biochemistry 343 1 (2005): 183-185. http://dx.doi.org/10.1016/j.ab.2005.03.011. Published • 10.1016/j.ab.2005.03.011 Tomaz, C^andida T.; Queiroz, João A.. "Fractionation of Trichoderma Reesei Cellulases by Hydrophobic Interaction Chromatography on Phenyl-Sepharose". Biotechnology Letters 26 3 (2004): 223-227. http://dx.doi.org/10.1023/b:bile.0000013719.92024.04. Published • 10.1023/b:bile.0000013719.92024.04 Tomaz, Cândida T.; Rocha, Ana S.; Queiroz, João A.. "Hydrophobic interaction chromatography ofTrichoderma reeseicellulases on polypropylene glycol–sepharose". Separation Science and Technology 37 7 (2002): 1641-1651. http://dx.doi.org/10.1081/ss-120002741. 10.1081/ss-120002741 Tomaz, C.T.; Duarte, D.; Queiroz, J.A.; Tomaz, Cândida T.; Duarte, Dina; Queiroz, João A.. "Comparative study on the fractionation of cellulases on some hydrophobic interaction chromatography adsorbents". Journal of Chromatography A 944 1-2 (2002): 211-216. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037168965&partnerID=MN8TOARS. 10.1016/S0021-9673(01)01224-9 Queiroz, J.A.; Tomaz, C. T.; Cabral, J.M.S.. "Hydrophobic interaction chromatography of proteins". Journal of Biotechnology 87 2 (2001): 143-159. http://dx.doi.org/10.1016/s0168-1656(01)00237-1. Published • 10.1016/s0168-1656(01)00237-1 Tomaz, C. T.; Queiroz, João A. "Studies on the chromatographic fractionation of Trichoderma reesei cellulases by hydrophobic interaction". Journal of Chromatography A 865 1-2 (1999): 123-128. http://dx.doi.org/10.1016/s0021-9673(99)00851-1. Published • 10.1016/s0021-9673(99)00851-1

Activities

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2019 - Current	Spectroscopic study of the interaction of lysozyme with phenolic compounds Co-supervisor of Daiana Rosso Ferreira Leithardt	Chemistry (PhD) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2017 - Current	Value of circulating endothelial progenitor cells as a predictor of response to cardiac resynchronization therapy Co-supervisor of Sílvia Martins	Biochemistry (PhD) Hospitais da Universidade de Coimbra Centro de Histocompatibilidade do Centro, Portugal Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2016 - 2022	Strategies for reducing the allergenicity of hen egg by treatment with natural antioxidants Supervisor of Alcides Walter Vapor	Biochemistry (PhD) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015 - 2020	Human vitreous proteome in vitreoretinal diseases Co-supervisor of Fátima Milhano Santos	Biochemistry (PhD) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2014 - 2018	Investigational Studies of Human Vitreous and Serum VEGF-A, VEGF-B and PIGF: Remodelling the Paradigm in Patients with Ocular Pathology Supervisor of Joana Mesquita	Biochemistry (PhD)
2011 - 2016	Production and characterization of new recombinant allergens from Alternaria alternata and Curvalaria lunata for application in the diagnosis and prognosis of respiratory allergies caused by fungi”. Supervisor of Marta Sofia da Fonseca Gabriel	Biochemistry (PhD) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal Universidad del País Vasco - Campus de Álava, Spain
2011 - 2016	Amino acid derivatized monoliths for purification of a DNA vaccine against Influenza Supervisor of Diana Faria Bicho	Biomedicine (PhD) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2009 - 2013	Novel Affinity Chromatography Processes for the Purification of Plasmid DNA Using Small Aromatic Molecules Supervisor of Catarina Caramelo Nunes	Biochemistry (PhD) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2006 - 2011	Characterization of latex allergens present in rubber gloves: new insights to explain different sensitization profiles in different risk groups Supervisor of Célia Marina António Peixinho	Biochemistry (PhD) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2008 - 2009	Antimicrobial susceptibility in clinical isolates of Staphylococcus aureus harbouring of mecA and lukFS-PV genes in Northern Portugal Co-supervisor of Nuno José Alves da Silva	Biochemistry (Master) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2008 - 2008	Effect of adenosin-angiotensin interactions on renal depuration of a diabetes experimental model Co-supervisor of Daniela Souto Patinha,	Biochemistry (Master) Universidade do Porto Faculdade de Medicina, Portugal Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2008 - 2008	Small-molecule boron compounds to use against interleukin-23 Supervisor	Biochemistry (Master) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2007 - 2008	Interference of Dermatophagoides specific IgG in the quantification of mite`s specific IgE Supervisor of Patrícia Isabel da Silva Fonseca "	Clinical Immunology (Master) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal Hospital de Sousa Martins, Portugal
2007 - 2008	Application of antibiotics as ligands in affinity chromatography for plasmid DNA purification Supervisor of Catarina Caramelo Nunes	Biochemistry (Master) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2007 - 2008	Quantitative analysis of five sterols in amniotic fluid by GC-MS: application to the diagnosis of cholesterol biosynthesis defects Co-supervisor of Cristina Isabel Borges Dias Amaral	Biochemistry (Master) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal Centro de Genética Médica Doutor Jacinto Magalhães, Portugal
2007 - 2008	Application of Hydrophobic Interaction Chromatography in separation of latex allergens Hev b 1 and Hev b 2 Supervisor of Nuno Miguel do Nascimento Fernandes	Biochemistry (Master)
2007 - 2008	Small natural ligands for plasmid purification by affinity methods Supervisor of Teresa Susana Ferreira Tente	Biochemistry (Master) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2006 - 2007	Food habits and student`s success in basic, secondary and professional schools at the municipally of Seia (Portugal) Co-supervisor of Carlos Rui Fernandes	Physics and Chemistry Teaching (Master) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2005 - 2006	Purification and separation of plasmid DNA isoforms using monolithic disks derivatized with histidine Supervisor of Inês Patrícia Vaz Batista Trindade	Physics and Chemistry Teaching (Master) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2004 - 2005	Identification and characterization of latex allergens present in external and external surfaces of cirurgical gloves Supervisor of Célia Marina António Peixinho	Clinical Immunology (Master) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Interview (tv / radio show)

	Program	Topic
2024/02/09 - 2024/02/09	Podcast "Mulheres Cientistas à Conversa" no âmbito das comemorações do "Dia Internacional das Mulheres e Raparigas na Ciência"	Mulheres Cientistas à Conversa

Distinctions

Award

2021	BInov 2021 Award, Innovation Scholarship Order of Pharmacists, Portugal
2019	Best Poster Presentation XX EuroFoodChem Conference, Portugal
2014	Best Poster Presentation European Academy of Allergy and Clinical Immunology, Switzerland
2013	Best Scientific Abstract European Academy of Allergy and Clinical Immunology, Switzerland
2012	Best Oral Communication Portuguese Society of Medical Hydrology, Portugal

Other distinction

2011	Best Poster
2010	Best Poster