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Danie José da Costa Barbosa has completed an Integrated Master in Pharmaceutical Sciences, in 2009, and a PhD in Pharmaceutical Sciences - Specialty of Toxicology, in 2013, at University of Porto. He is currently Invited Assistant Professor at Cooperativa de Ensino Superior Politécnico e Universitário (CESPU) and Integrated Researcher at Associate Laboratory i4HB - Institute for Health and Bioeconomy, University Institute of Health Sciences - CESPU and UCIBIO - Applied Molecular Biosciences Unit, Translational Toxicology Research Laboratory, University Institute of Health Sciences (1H-TOXRUN, IUCS-CESPU. Daniel Barbosa works in the areas of Molecular and Cell Biology, Neurosciences, Pharmacology, Toxicology and Forensic Sciences. He published 38 articles in Peer Review International Journals (most of the journals Q1 on their respective fields), 17 abstracts in Peer Review International Journals, and 3 book chapters. Daniel Barbosa has several poster presentations and oral presentations in national and international conferences. He participates or participated in 8 research projects funded by national and international agencies. Over the years, he has served as a reviewer for several Peer Review International Journals. He has supervised 2 Pre-Graduated Students and a Master Student, and co-supervised a Master Student and a PhD Student. At the present, he supervises a Master Student and 3 Pre-Graduated Students, and co-supervises 2 PhD Students and 2 Master Students. In his Curriculum Vitae , the most frequent terms in the context of scientific and technological production are: microtubules, intracellular transport, molecular motors, dynein, dynactin, intracellular organelles, CRISPR-Cas9, C. elegans, oxidative stress, MDMA ("ecstasy"), drugs of abuse, neurosciences, neurotoxicology, forensic sciences, forensic toxicology.
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Identification

Personal identification

Full name
Daniel José da Costa Barbosa

Citation names

  • Barbosa, Daniel José
  • Barbosa, DJ
  • Barbosa, D.J.

Author identifiers

Ciência ID
FE1C-104F-37C1
ORCID iD
0000-0002-1726-6011
Scopus Author Id
54931587700

Email addresses

  • daniel.barbosa@iucs.cespu.pt (Professional)

Addresses

  • Instituto Universitário de Ciências da Saúde (IUCS), Rua Central da Gandra 1317 4585, Gandra, 4585, Gandra, Paredes, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Medical and Health Sciences - Other Medical Sciences - Forensic Science
  • Medical and Health Sciences - Basic Medicine - Toxicology
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
French Elementary (A2) Intermediate (B1) Elementary (A2) Elementary (A2) Beginner (A1)
Spanish; Castilian Intermediate (B1) Upper intermediate (B2) Elementary (A2) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2013/12/20
Concluded
 Ciências Farmacêuticas (Doutoramento)
Major in Especialidade: Toxicologia
Universidade do Porto Faculdade de Farmácia, Portugal
"Ecstasy´s Neurotoxicity: In Vitro Findings from Mitochondria to the Cell" (THESIS/DISSERTATION)
2009/09/24
Concluded
 Integrated Master in Pharmaceutical Sciences (Mestrado integrado)
Universidade do Porto Faculdade de Farmácia, Portugal
"Factores que influenciam a utilização de estatinas e seus benefícios para além das dislipidémias" (THESIS/DISSERTATION)
 15
2008/06/13
Concluded
 Degree on Basic Studies in Pharmaceutical Sciences (Licenciatura)
Universidade do Porto Faculdade de Farmácia, Portugal
 14
Affiliation

Science

Category
Host institution 		Employer
2024/03/01 - Current Researcher (Research) Unidade de Ciências Biomoleculares Aplicadas, Portugal
Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2019/01/01 - 2024/02/29 Contracted Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
(...)
2014/04/01 - 2018/12/31 Postdoc (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
(...)
2009/03/01 - 2009/09/30 Research Trainee (Research) Universidade do Porto Faculdade de Farmácia, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2019/02/01 - Current Invited Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
Instituto Universitário de Ciências da Saúde, Portugal
2018 - 2019 Invited Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
Instituto Universitário de Ciências da Saúde, Portugal
2010/04/01 - 2013/12/31 Tutor (University Teacher) Universidade do Porto Faculdade de Farmácia, Portugal
Universidade do Porto Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
2009/09 - 2010/01 Pharmacist Lemos & Fihos, Lda , Portugal
Projects

Grant

Designation Funders
2014/04/01 - 2019/10/31 Cytoplasmic Dynein: Mechanisms of Regulation and Novel Interactors
info:eu-repo/grantAgreement/EC/FP7/338410/EU
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 European Commission
Concluded
2015/03/01 - 2018/12/31 Neurodegenerative diseases caused by mutations in p150/Glued: Generation of novel animal models and identification of disease modifiers
SFRH/BPD/101898/2014
Post-doc Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/02/01 - 2013/12/31 Contribution of mitochondrial dysfunction for the neurotoxic effects of 3,4-methylenedioxymethamphetamine (MDMA; Ecstasy)
SFRH/BD/64939/2009
PhD Student Fellow
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/01/01 - Current Institute for Research and Innovation in Health
LA/P/0070/2020
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Ongoing
2020/01/01 - Current Institute for Research and Innovation in Health
UIDB/04293/2020
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/01/01 - Current Institute for Research and Innovation in Health
UIDP/04293/2020
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Ongoing
2019/01/01 - Current Institute for Research and Innovation in Health
DL 57/2016/CP1355/CT0007
Researcher
Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
Researcher
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade NOVA de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01 - 2024/02/29 Axonal transport regulation by motor-cargo adaptors
PTDC/BIA-CEL/1321/2021
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/07/01 - 2023/12/31 PhasAGE - Excellence Hub on Phase Transitions in Aging and Age-Related Disorders
H2020-WIDESPREAD-2020-5
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Concluded
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
10.54499/UIDB/04378/2020
Researcher
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDP/04378/2020
10.54499/UIDP/04378/2020
Researcher
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2022/09/01 - 2023/09/30 Consequences of axonal demyelination for mitochondria biology
Mddemy-GI2-CESPU-2022
Principal investigator
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
 Cooperativa de Ensino Superior Politécnico e Universitário
Concluded
2018/07/01 - 2021/06/30 Molecular mechanisms of the dynein-dynactin transport machinery in health and disease
PTDC/BIA-CEL/30507/2017
Researcher
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Instituto de Investigação e Inovação em Saúde
UID/BIM/04293/2019
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/03/01 - 2013/11/30 Implications of amphetamine psychostimulants abuse in brain ageing
PTDC/SAU-FCF/102958/2008
Researcher
Universidade do Porto Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade de Coimbra, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Barbosa, Daniel José; Carvalho, Félix; Carmo, Helena. "The mitochondrial disruption as a contributing factor for the neurotoxicity of amphetamines". In Mitochondrial Intoxication. United States: Elsevier, 2023.
    Published
  2. Barbosa, Daniel José (FE1C-104F-37C1); Capela, João Paulo; Bastos, Maria de Lourdes; Carvalho, F.. "Involvement of Mitochondrial Dysfunction on the Toxic Effects Caused by Drugs of Abuse and Addiction". In Mitochondrial Dysfunction Caused by Drugs and Environmental Toxicants, 487-508. Jersey City, United States: John Wiley & Sons, Inc., 2018.
    Published
  3. Barbosa, Daniel José (FE1C-104F-37C1); Capela, João Paulo; De Lourdes Bastos, M.; Carvalho, E.. "Mitochondrial Trails in the Neurotoxic Mechanisms of MDMA". In Neuropathology of Drug Addictions and Substance Misuse, edited by Victor R. Preedy. Elsevier, 2016.
    Published • 10.1016/B978-0-12-800212-4.00040-6
Conference abstract
  1. Gil-Martins, E.; F. Cagide-Fagín; A. Borer; Barbosa, DJ; Carlos Fernandes; Fernando Remião; Borges, Fernanda; Silva, Renata. "Insights into the mechanistic pathways underlying the neurotoxic effects of 2C-I and 25I-NBOMe drugs". Paper presented in 58th Congress of the European Societies of Toxicology (EUROTOX 2024), Copenhagen, 2024.
    Published
  2. Ana Cláudia-Ferreira; Barbosa, DJ; Carla Campos; Dinis-Oliveira, Ricardo Jorge; Ana R. Freitas. "Mapping of key bacterial species for postmortem interval calculation". Paper presented in III 1H-TOXRUN INTERNATIONAL CONGRESS, Porto, 2024.
    Published
  3. Silva, R.; Barbosa, D.J.; Carmo, H.; Carvalho, F.; da Silva, D. Dias; Silva, João Pedro. Corresponding author: Silva, João Pedro. "P21-18: The impact of ADB-FUBINACA on the differentiation, maturation and astrocyte activation in in vitro primary hippocampal cultures". Paper presented in EUROTOX 2023, Ljubljana, 2023.
    Published • 10.1016/s0378-4274(23)00825-1
  4. Gil-Martins, Eva; Cagide, Fernando; Borer A; Barbosa, DJ; Martins D; Fernandes C; Remião, Fernando; Borges F; Renata Silva. "Mechanisms behind the neurotoxicity of 2C-I and 25I-NBOMe drugs". Paper presented in II Toxrun International Congress, Porto, 2023.
    Published
  5. Barbosa, Daniel José. "The synthetic cannabinoid THJ-2201 increases the differentiation of primary hippocampal neurons and early astrocyte activation but decreases neuronal maturation". Paper presented in The XVI Internatonal Congress of Toxicology, Maastricht, 2022.
    Published
  6. Bravo, R. Roque; Barbosa, D. J.; Carmo, H.; Silva, J. P.; Carvalho, F.; Da Silva, D. Dias. "The influence of selected synthetic cannabinoids on in vitro proliferation and viability of neuronal cell models". Paper presented in XVIth International Congress of Toxicology (ICT 2022), Maastricht, 2022.
    Published • 10.1016/J.TOXLET.2022.07.163
  7. Ana Cláudia-Ferreira; Barbosa, Daniel José; Dinis-Oliveira, Ricardo Jorge; Ana Raquel Freitas. "Current perspective on the relevance of bacterial communities to estimate post-mortem intervals - how far are we?". Paper presented in I Toxrun International Congress and V International Congress of the Portuguese Association of Forensic Sciences, Porto, 2022.
    Published
  8. Roque Bravo, Rita; Barbosa, Daniel José; Carmo, Helena; João Pedro Silva; Carvalho, Félix; Diana Dias da Silva. "Synthetic cannabinoids AMB-FUBINACA, ADB-FUBINACA, AB-CHMINACA and THJ-2201 impact on in vitro viability and proliferation of primary rat hippocampal neurons and SH-SY5Y cells". Paper presented in I Toxrun International Congress and V International Congress of the Portuguese Association of Forensic Sciences, Porto, 2022.
    Published
  9. Gil-Martins, E.; Barbosa, D. J.; Sousa, E.; Resende, D.; Remiao, F.; Silva, R.. "P-glycoprotein modulation by xanthonic derivatives: a strategy to fight Alzheimer's disease". Paper presented in 55th Congress of the European Societies of Toxicology (EUROTOX 2019), Helsinki, 2019.
    Published
  10. Martins, E.; Barbosa, D.J.; Sousa, E.; Resende, D.; Pinto, M.; Remião, F.; Silva, R.. "Newly synthetized xanthonic derivatives as potential P-glycoprotein modulators: a strategy to fight Alzheimer¿s disease". Paper presented in 12ª Edição Encontro de Investigação Jovem da Universidade do Porto (IJUP), Porto, 2019.
    Published
  11. Martins, E.; Barbosa, D.J.; Sousa, E.; Resende, D.; Pinto, M.; Remião, F.; Silva, R.. "In vitro modulation of P-glycoprotein by xanthonic derivates: implications on Alzheimer's disease". Paper presented in SPF Meeting 2019 - Reunião Anual da Sociedade Portuguesa de Farmacologia, Porto, 2019.
    Published
  12. Duro, J.; Gama, J. B.; Barbosa, D. J.; Carvalho, C.; Celestino, R.; Carvalho, A. X.; Gassmann, R.. "A C. elegans dynactin p150 mutant with reduced affinity for dynein intermediate chain uncouples dynein recruitment from dynein activation". Paper presented in In ASCB|EMBO Annual Meeting, San Diego, 2018.
    Published
  13. Silva, R.; Carmo, H.; Vilas-Boas, V.; Barbosa, D. J.; Palmeira, A.; Sousa, E.; Bastos, Maria de Lourdes; Remião, Fernando. "Hypericin-mediated P-glycoprotein induction protects caco-2 cells against paraquat toxicity: In vitro and in silico studies". Porto, 2015.
    Published • 10.1016/J.TOXLET.2015.08.905
  14. Feio-Azevedo, R.; Costa, Vera Marisa; Gomes, Ana; Pita, Inês; Sequeira, A; Pereira, Frederico; Duarte-Araújo, M.; et al. "Aged rats are more prone to ecstasy neurotoxicity than adolescent rats". Paper presented in 50th Congress of the European Societies of Toxicology (EUROTOX), Edimburgo, 2014.
    Published
  15. Silva, Renata; Gameiro, Mariline; Sousa, Emilia; Carmo, Helena; Paiva, AM; Barbosa, Daniel José (FE1C-104F-37C1); Pinto, Madalena; Bastos, Maria de Lourdes; Remião, Fernando. "New thioxanthones and dihydroxylated xanthones as P-glycoprotein inducers/activators". Paper presented in 50th Congress of the European Societies of Toxicology (EUROTOX), Edimburgo, 2014.
    Published
  16. Arbo, Marcelo; Silva, Renata; Barbosa, Daniel José (FE1C-104F-37C1); Dias da Silva, Diana; Bastos, Maria de Lourdes; Carmo, Helena. "Piperazine designer drugs are cytotoxic to human neuroblastoma SH-SY5Y cells". Paper presented in 50th Congress of the European Societies of Toxicology (EUROTOX), Edimburgo, 2014.
    Published
  17. Azevedo, Rita; Costa, Vera M.; Barbosa, Daniel; Gomes, Armanda; Pita, Ines; Sequeira, Ana; Pereira, Frederico; et al. "Aged rats are more prone to "ecstasy" neurotoxicity than adolescent rats". Paper presented in 50th Congress of the European Societies of Toxicology (EUROTOX), Edimburgo, 2014.
    Published • 10.1016/J.TOXLET.2014.06.804
  18. Barbosa, Daniel José (FE1C-104F-37C1); Serrat, Romàn; Mirra, Serena; Quevedo, Martí; Barreda, Elena Gomes; Àvila, Jesus; Fernandes, Eduarda; et al. ""Ecstasy" impairs mitochondrial trafficking in hippocampal neurons by a Tau phosphorylation-dependent mechanism involving GSK3ß". Paper presented in 49th Congress of the European Societies of Toxicology (EUROTOX), Interlaken, 2013.
    Published
  19. Remião, Fernando; Silva, Renata; Vilas-Boas, Vânia; Barbosa, Daniel José (FE1C-104F-37C1); Palmeira, Andreia; Sousa, Emília; Carvalho, Félix; Bastos, Maria de Lourdes; Carmo, Helena. "P-glycoprotein expression and activity are differently modulated by Colchicine in Caco-2 cells: In vitro and in silico studies.". Paper presented in 49th Congress of the European Societies of Toxicology (EUROTOX), Interlaken, 2013.
    Published
  20. Barbosa, Daniel Jose; Capela, Joao Paulo; Ferreira, Luisa Maria; Branco, Paula; Fernandes, Eduarda; Bastos, Maria de Lourdes; Carvalho, Felix; et al. "Mixture of "Ecstasy" and its metabolites are toxic to SH-SY5Y differentiated cells". Paper presented in 48th Congress of the European Societies of Toxicology (EUROTOX), Estocolmo, 2012.
    Published • 10.1016/J.TOXLET.2012.03.688
  21. Barbosa, Daniel José (FE1C-104F-37C1); Capela, João Paulo; Oliveira, Jorge Miguel Ascenção; Ferreira, Luisa; Branco, Paula; Fernandes, Eduarda; Bastos, Maria de Lourdes; Carvalho, Félix. "Pro-oxidant effects of "ecstasy" and its metabolites in mouse brain synaptosomes". Paper presented in 47th Congress of the European Societies of Toxicology (EUROTOX), Paris, 2011.
    Published
  22. José Barbosa, Daniel; Ferreira, Luisa; Branco, Paula; Fernandes, Eduarda; Carmo, Helena; Remião, Fernando; Bastos, Maria de Loudes; et al. "Evaluation of the oxidative damage induced by MDMA and its metabolites in rat brain synaptosomes". Paper presented in XII International Congress of Toxicology (IUTOX), Barcelona, 2010.
    Published
  23. Barbosa, D. J.; Ferreira, L.; Serio Branco, P.; Fernandes, E.; Carmo, H.; Remiao, F.; Bastos, M. L.; et al. "Evaluation of the oxidative damage induced by MDMA and its metabolites in rat brain synaptosomes". 2010.
    10.1016/J.TOXLET.2010.03.765
Conference poster
  1. Ivo Lacerda; Barbosa, DJ. "The hepatotoxicity of nimesulide reflected in fatal and non-fatal intoxications". Paper presented in VI Congress of the Portuguese Association of Forensic Sciences, 2024.
  2. Ivo Lacerda; Manuela Oliveira; Barbosa, D.J.. "Genotoxicity of the non-steroidal anti-inflammatory drugs naproxen and nimesulide". Paper presented in XXII Portuguese Congress of Legal Medicine and Forensic Sciences, 2024.
  3. Moyisyeyenko, Tatiana; Dinis-Oliveira, Ricardo Jorge; Barbosa, Daniel José. "Intoxications and fatalities involving new psychoactive substances in 2023 and the influence of ethanol". Paper presented in XXII Portuguese Congress of Legal Medicine and Forensic Sciences, 2024.
  4. Gil-Martins, E.; Cagide, Fernando; Ana Borer; Barbosa, DJ; Fernandes, Carlos; Remião F; Fernanda Borges; Renata Silva. "Insights into the mechanistic pathways underlying the neurotoxic effects of 2C-I and 25I-NBOMe drugs.". Paper presented in III 1H-TOXRUN INTERNATIONAL CONGRESS, 2024.
  5. Cláudia-Ferreira A; Barbosa, DJ; Carla Campos; Dinis-Oliveira, Ricardo Jorge; Ana Raquel Freitas. "Mapping of key bacterial species for Postmortem interval calculation". Paper presented in III 1H-TOXRUN INTERNATIONAL CONGRESS, 2024.
  6. Silva, Rafaela; Barbosa, Daniel José; Carmo, Helena; Carvalho, Félix; da Silva, D. Dias; Silva, João Pedro. Corresponding author: Silva, João Pedro. "The impact of ADB-FUBINACA on the differentiation, maturation and astrocyte activation in in vitro primary hippocampal cultures.". Paper presented in EUROTOX 2023, 2023.
  7. Gil-Martins, Eva; Cagide, Fernando; Borer A; Barbosa, DJ; Martins D; Fernandes C; Remião, Fernando; Borges F; Renata Silva. "Mechanisms behind the neurotoxicity of 2C-I and 25I-NBOMe drugs". Paper presented in II Toxrun International Congress, 2023.
  8. Remiao, Fernando; Silva, Renata; Vilas-Boas, Vania; Barbosa, Daniel Jose; Palmeira, Andreia; Sousa, Emilia; Carvalho, Felix; Bastos, Maria de Lourdes; Carmo, Helena. "P-glycoprotein expression and activity are differently modulated by Colchicine in Caco-2 cells: In vitro and in silico studies". Paper presented in 49th Congress of the European Societies of Toxicology (EUROTOX), 2023.
    10.1016/J.TOXLET.2013.05.401
  9. Carvalho, Cátia; Barbosa, Daniel José; Gassmann, Reto. "Dynein-1 and cell shape work together to ensure proper tissue architecture of the Caenorhabditis elegans epidermis". Paper presented in 5th PhDay – “Building Paths: The Science Behind Us”, 2022.
  10. Barbosa, Daniel José. "The synthetic cannabinoid THJ-2201 increases the differentiation of primary hippocampal neurons and early astrocyte activation but decreases neuronal maturation". Paper presented in The XVI Internatonal Congress of Toxicology, 2022.
  11. Barbosa, Daniel José. "The influence of selected synthetic cannabinoids on in vitro proliferation and viability of neuronal cell models". Paper presented in The XVI Internatonal Congress of Toxicology, 2022.
  12. Eva Gil Martins; F. Cagide-Fagín; Barbosa, Daniel José; Daniel Martins; Carlos Fernandes; Fernando Remião; Fernanda Borges; Renata Silva. "Neurotoxic profile of psychedelic phenethylamine derivatives.". Paper presented in MedChem22 (X Meeting of the Paul Ehrlich Euro-PhD Network), 2022.
  13. Ana Cláudia-Ferreira; Barbosa, Daniel José; Dinis-Oliveira, Ricardo Jorge; Ana Raquel Freitas. "Current perspective on the relevance of bacterial communities to estimate post-mortem intervals - how far are we?". Paper presented in I Toxrun International Congress and V International Congress of the Portuguese Association of Forensic Sciences, 2022.
  14. Roque Bravo, Rita; Barbosa, Daniel José; Carmo, Helena; Carvalho, Félix; Silva, João Pedro; da Silva, Diana Dias. "Synthetic cannabinoids AMB-FUBINACA, ADB-FUBINACA, AB-CHMINACA and THJ-2201 impact on in vitro viability and proliferation of primary rat hippocampal neurons and SH-SY5Y cells". Paper presented in I Toxrun International Congress and V International Congress of the Portuguese Association of Forensic Sciences, 2022.
  15. Duro, Joana; Gama, José Bernardo; Barbosa, Daniel José (FE1C-104F-37C1); Carvalho, Cátia; Gassmann, Reto. "A C. elegans dynactin p150 mutant with reduced affinity for dynein intermediate chain uncouples dynein recruitment from dynein activation". Paper presented in ASCB|EMBO Annual Meeting, 2018.
  16. Marins, Eva; Barbosa, Daniel José (FE1C-104F-37C1); Palmeira, Andreia; Sousa, Emilia; Lemos, A; Carmo, Helena; Pinto, Madalena; et al. "P-gp induction and activation by newly synthesized xanthonic derivatives as a potential therapeutic approach in intoxications and neurological diseases". Paper presented in Italian-Spanish-Portuguese Joint Meeting in Medicinal Chemistry 2018, 2018.
  17. Carvalho, Cátia; Celestino, Ricardo; Gama, José Bernardo; Barbosa, Daniel José (FE1C-104F-37C1); Gassmann, Reto. "A short helix in the C-terminal region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport". Paper presented in EMBO Workshop: C. elegans development, cell biology and gene expression, 2018.
  18. Duro, Joana; Barbosa, Daniel José (FE1C-104F-37C1); Gassmann, Reto. "Characterization of a p150/DNC-1 mutant that uncouples dynactin’s role in dynein recruitment from its role in dynein activation". Paper presented in EMBO Workshop: C. elegans development, cell biology and gene expression, 2018.
  19. Celestino, Ricardo; Gama, José Bernardo; Henen, M; Carvalho, Cátia; Barbosa, Daniel José (FE1C-104F-37C1); Vögeli, B.; Gassmann, Reto. "A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport". Paper presented in EMBO/EMBL Symposium: Microtubules: From Atoms to Complex Systems, 2018.
  20. Barbosa, Daniel José (FE1C-104F-37C1); Silva, Tânia Magalhães; Fernendes, Joana; Simões, Patricia Alexandra; Gassmann, Reto. "Dissecting the mitotic functions of dynactin in the early C. elegans embryo". Paper presented in EMBO/EMBL Symposium: Microtubules: From Atoms to Complex Systems, 2016.
  21. Silva, Renata; Palmeira, A.; Carmo, H.; Barbosa, DJ; Gameiro, M.; Sousa, E.; Pinto, M.; Bastos, M.L.; Remião, Fernando. "P-glycoprotein induction by newly synthetized (thio)xanthones prevents Paraquat cytotoxicity.". Paper presented in 55th Annual Meeting and ToxExpo, March 13-17 2016, NewOrleans, Louisiana, USA., 2016.
  22. Silva, Renata; Carmo, Helena; Vilas-Boas, Vânia; Palmeira, Andreia; Sousa, Emilia; Bastos, Maria de Lourdes; Remião, Fernando. "Hypericin-mediated P-glycoprotein induction protects caco-2 cells against paraquat toxicity: in vitro and in silico studies". Paper presented in 51st Congress of the European Societies of Toxicology (EUROTOX), 2015.
  23. Feio-Azevedo, Rita; Costa, Vera Marisa; Gomes, A; Pita, Inês; Sequira, A; Pereira, Frederico; Duarte-Araújo, Margarida; et al. "Aged rats are more prone to “ecstasy” neurotoxicity than adolescent rats". Paper presented in 50th Congress of the European Societies of Toxicology (EUROTOX), 2014.
  24. Arbo, Marcelo; Silva, Renata; Silva, Diana Dias; Bastos, Maria de Lourdes; Carmo, Helena. "Piperazine designer drugs are cytotoxic to human neuroblastoma SH-SY5Y cells". Paper presented in 50th Congress of the European Societies of Toxicology (EUROTOX), 2014.
  25. Silva, Renata; Gameiro, Mariline; Sousa, Emília; Carmo, Helena; Paiva, Ana Mafalda; Barbosa, Daniel José (FE1C-104F-37C1); Pinto, Madalena; Bastos, Maria de Lourdes; Remião, Fernando. "New thioxanthones and dihydroxylated xanthones as P-glycoprotein inducers/activators". Paper presented in 50th Congress of the European Societies of Toxicology (EUROTOX), 2014.
  26. Barbosa, Daniel José (FE1C-104F-37C1); Serrat, Romàn; Mirra, Serena; Quevedo, Martí; Barreda, EG; Àvila, Jesus; Fernandes, Eduarda; et al. "Ecstasy impairs mitochondrial trafficking in hippocampal neurons by a Tau phosphorylation-dependent mechanism involving GSK3ß". Paper presented in 49th Congress of the European Societies of Toxicology (EUROTOX), 2013.
    10.1158/1538-7445.am2019-1480
  27. Barbosa, Daniel José (FE1C-104F-37C1); Capela, João Paulo; Silva, Renata; Ferreira, Luísa Maria ; Branco, Paula Sério; Fernandes, Eduarda; Bastos, Maria de Lourdes; Carvalho, Félix. "The mixture of "Ecstasy" and its metabolites, at low concentrations, is toxic to SH-SY5Y differentiated cells". Paper presented in 48th Congress of the European Societies of Toxicology (EUROTOX), 2012.
  28. Barbosa, Daniel José (FE1C-104F-37C1); Capela, João Paulo; Oliveira, Jorge Miguel Ascenção; Silva, Renata; Ferreira, Luísa Maria ; Siopa, Filipa; Branco, Paula Sério; et al. "Pro-oxidant effects of "ecstasy" and its metabolites in mouse brain synaptosomes". Paper presented in 47th Congress of the European Societies of Toxicology (EUROTOX), 2011.
  29. Barbosa, Daniel José; Capela, João Paulo; Oliveira, Jorge Miguel Ascenção; Silva, Renata; Ferreira, Luísa Maria ; Branco, Paula Sério; Fernandes, Eduarda; et al. "Pro-oxidant effects of "Ecstasy" and its metabolites in mouse brain synaptosomes". Paper presented in XVII Congresso Nacional de Bioquímica, 2010.
  30. Barbosa, Daniel José; Ferreira, Luísa Maria ; Branco, Paula Sério; Fernandes, Eduarda; Carmo, Helena; Remião, Fernando; Bastos, Maria de Lourdes; et al. "Evaluation of the oxidative damage induced by MDMA and its metabolites in rat brain synaptosomes". Paper presented in XII International Congress of Toxicology (IUTOX), 2010.
  31. Soares, Helena; Caetano, Susana; Barbosa, Daniel José (FE1C-104F-37C1); Areias, Cristiana. "Utilização de Antídotos no Centro Hospitalar do Porto - Hospital de Santo António". Paper presented in XIII Simpósio da Associação Portuguesa de Farmacêuticos Hospitalares, 2009.
  32. Barbosa, Daniel José (FE1C-104F-37C1); Cardoso, Ricardo; Pereira, Ricardo. "Estudo das interferências das cumarinas naturais ingeridas na dieta na terapêutica anticoagulante oral com varfarina". Paper presented in I Meeting of Human Food, IV Meeting of Pharmaceutical Chemistry, 2008.
Journal article
  1. Carvalho, Cátia; Moreira, Matilde; Barbosa, Daniel J.; Chan, Fung-Yi; Koehnen, Carlota Boal; Teixeira, Vanessa; Rocha, Helder; et al. "ZYG-12/Hook's dual role as a dynein adaptor for early endosomes and nuclei is regulated by alternative splicing of its cargo binding domain". Molecular Biology of the Cell (2024): https://doi.org/10.1091/mbc.e24-08-0364.
    Published • 10.1091/mbc.e24-08-0364
  2. Barbosa, Daniel José; Barbosa, Joana; Souza-Fagundes, Elaine M.; Silva, Patrícia M. A.. "The (un)desirability of cell death in health and disease: emerging modulators and their mechanisms". Frontiers in Cell and Developmental Biology 12 (2024): https://doi.org/10.3389/fcell.2024.1523293.
    Published • 10.3389/fcell.2024.1523293
  3. Silva, Renata; Sobral, Ana Filipa; Dinis-Oliveira, Ricardo Jorge; Barbosa, Daniel José. "The Link Between Paraquat and Demyelination: A Review of Current Evidence". Antioxidants 13 11 (2024): 1354. https://doi.org/10.3390/antiox13111354.
    10.3390/antiox13111354
  4. Daniel José Barbosa; Cátia Carvalho; Inês Costa; Renata Silva. "Molecular Motors in Myelination and Their Misregulation in Disease". Molecular Neurobiology (2024): https://doi.org/10.1007/s12035-024-04576-9.
    Published • 10.1007/s12035-024-04576-9
  5. Sobral, Ana Filipa; Dinis-Oliveira, Ricardo Jorge; Barbosa, Daniel José. "CRISPR-Cas technology in forensic investigations: Principles, applications, and ethical considerations". Forensic Science International: Genetics 74 (2024): 103163. https://doi.org/10.1016/j.fsigen.2024.103163.
    Open access • Published • 10.1016/j.fsigen.2024.103163
  6. Ana Filipa Sobral; Andrea Cunha; Vera Silva; Eva Gil-Martins; Renata Silva; Daniel José Barbosa. "Unveiling the Therapeutic Potential of Folate-Dependent One-Carbon Metabolism in Cancer and Neurodegeneration". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25179339.
    Published • 10.3390/ijms25179339
  7. Eva Gil-Martins; Fernando Cagide-Fagín; Daniel Martins; Ana Borer; Daniel José Barbosa; Carlos Fernandes; Daniel Chavarria; et al. "Mechanistic Insights into the Neurotoxicity of 2,5-Dimethoxyphenethylamines (2C) and Corresponding N-(2-methoxybenzyl)phenethylamine (NBOMe) Drugs". Journal of Xenobiotics (2024): https://doi.org/10.3390/jox14020044.
    10.3390/jox14020044
  8. Inês C. Santos; Daniela Maia; Ricardo Jorge Dinis-Oliveira; Daniel José Barbosa. "New Psychoactive Substances: Health and Legal Challenges". Psychoactives (2024): https://doi.org/10.3390/psychoactives3020018.
    Published • 10.3390/psychoactives3020018
  9. Monteiro, Ana Rita; Barbosa, Daniel José; Remião, Fernando; Silva, Renata. "Co-Culture Models: Key Players in In Vitro Neurotoxicity, Neurodegeneration and BBB Modeling Studies". Biomedicines 12 3 (2024): 626. https://doi.org/10.3390/biomedicines12030626.
    Published • 10.3390/biomedicines12030626
  10. Cátia Carvalho; Daniel J Barbosa; Ricardo Celestino; Esther Zanin; Ana Xavier Carvalho; Reto Gassmann; M Boxem. "Dynein directs prophase centrosome migration to control the stem cell division axis in the developing Caenorhabditis elegans epidermis". GENETICS (2024): https://doi.org/10.1093/genetics/iyae005.
    10.1093/genetics/iyae005
  11. Pinto, Bárbara; Silva, João P. N.; Silva, Patrícia M. A.; Barbosa, Daniel José; Sarmento, Bruno; Tavares, Juliana Carvalho; Bousbaa, Hassan. "Maximizing Anticancer Response with MPS1 and CENPE Inhibition Alongside Apoptosis Induction". Pharmaceutics 16 1 (2023): 56. http://dx.doi.org/10.3390/pharmaceutics16010056.
    Published • 10.3390/pharmaceutics16010056
  12. Ana Cláudia-Ferreira; Daniel José Barbosa; Veroniek Saegeman; Amparo Fernández-Rodríguez; Ricardo Jorge Dinis-Oliveira; Ana R. Freitas. "The future is now: unraveling the expanding potential of human (necro)microbiome in forensic investigations". Microorganisms (2023): https://doi.org/10.3390/microorganisms11102509.
    Published • 10.3390/microorganisms11102509
  13. Monteiro, Ana R.; Barbosa, Daniel J.; Remião, Fernando; Silva, Renata. "Alzheimer’s disease: Insights and new prospects in disease pathophysiology, biomarkers and disease-modifying drugs". Biochemical Pharmacology 211 (2023): 115522. https://doi.org/10.1016/j.bcp.2023.115522.
    10.1016/j.bcp.2023.115522
  14. Inês Costa; Daniel José Barbosa; Vera Silva; Sofia Benfeito; Fernanda Borges; Fernando Remião; Renata Silva. "Research Models to Study Ferroptosis Impact in Neurodegenerative Diseases". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15051369.
    Published • 10.3390/pharmaceutics15051369
  15. Costa, Inês; Barbosa, Daniel José; Benfeito, Sofia; Silva, Vera; Chavarria, Daniel; Borges, Fernanda; Remião, Fernando; Silva, Renata. "Molecular mechanisms of ferroptosis and their involvement in brain diseases". Pharmacology & Therapeutics 244 (2023): 108373. https://doi.org/10.1016/j.pharmthera.2023.108373.
    Published • 10.1016/j.pharmthera.2023.108373
  16. Daniel José Barbosa; João Paulo Capela; Luísa Maria Ferreira; Paula Sério Branco; Eduarda Fernandes; Maria de Lourdes Bastos; Félix Carvalho. "Ecstasy metabolites and monoamine neurotransmitters upshift the Na+/K+ ATPase activity in mouse brain synaptosomes". Archives of Toxicology (2022): https://doi.org/10.1007/s00204-022-03370-7.
    Published • 10.1007/s00204-022-03370-7
  17. Ricardo Celestino; José Gama; Artur Castro-Rodrigues; Barbosa, Daniel José; Helder Rocha; Ennio d'Amico; Andrea Musacchio; et al. "JIP3 interacts with dynein and kinesin-1 to regulate bi-directional organelle transport". Journal of Cell Biology (2022): https://doi.org/10.1083/jcb.202110057.
    Published • 10.1083/jcb.202110057
  18. Ana Filipa Sobral; Fung-Yi Chan; Michael J. Norman; Daniel S. Osório; Ana Beatriz Dias; Vanessa Ferreira; Daniel J. Barbosa; et al. "Plastin and spectrin cooperate to stabilize the actomyosin cortex during cytokinesis". Current Biology (2021): https://doi.org/10.1016/j.cub.2021.09.055.
    Published • 10.1016/j.cub.2021.09.055
  19. Barbosa, Daniel J.; Teixeira, Vanessa; Duro, Joana; Carvalho, Ana X.; Gassmann, Reto. "Dynein-dynactin segregate meiotic chromosomes in C. elegans spermatocytes". Development 148 3 (2021): http://dx.doi.org/10.1242/dev.197780.
    Published • 10.1242/dev.197780
  20. Gil-Martins, Eva; Barbosa, Daniel José; Silva, Vera; Remião, Fernando; Silva, Renata. "Dysfunction of ABC transporters at the blood-brain barrier: Role in neurological disorders". Pharmacology & Therapeutics (2020): 107554. http://dx.doi.org/10.1016/j.pharmthera.2020.107554.
    Published • 10.1016/j.pharmthera.2020.107554
  21. Celestino, R.; Henen, M.A.; Gama, J.B.; Carvalho, C.; McCabe, M.; Barbosa, Daniel José (FE1C-104F-37C1); Born, A.; et al. "A transient helix in the disordered region of dynein light intermediate chain links the motor to structurally diverse adaptors for cargo transport". PLoS Biology 17 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85060185140&partnerID=MN8TOARS.
    Published • 10.1371/journal.pbio.3000100
  22. Feio-Azevedo, R.; Costa, Vera Marisa; Barbosa, Daniel José (FE1C-104F-37C1); Teixeira-Gomes, A.; Pita, I.; Gomes, S.; Pereira, F.C.; et al. "Aged rats are more vulnerable than adolescents to "ecstasy"-induced toxicity". Archives of Toxicology 92 7 (2018): 2275-2295. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047997081&partnerID=MN8TOARS.
    Published • 10.1007/s00204-018-2226-8
  23. Barbosa, Daniel José (FE1C-104F-37C1); Duro, J.; Prevo, B.; Cheerambathur, D.K.; Carvalho, A.X.; Gassmann, R.. "Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport". PLoS Genetics 13 7 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85026624927&partnerID=MN8TOARS.
    Published • 10.1371/journal.pgen.1006941
  24. Gama, J.B.; Pereira, C.; Simões, P.A.; Celestin, R.; Reis, R.M.; Pires, H.R.; Carvalho, C.; et al. "Molecular mechanism of dynein recruitment to kinetochores by the Rod-Zw10-Zwilch complex and Spindly". Journal of Cell Biology 216 4 (2017): 943-960. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021847678&partnerID=MN8TOARS.
    Published • 10.1083/jcb.201610108
  25. Arbo, M.D.; Silva, Renata; Barbosa, Daniel José; da Silva, D.D.; Silva, S.P.; Teixeira, J.P.; Bastos, M.L.; Carmo, H.. "In vitro neurotoxicity evaluation of piperazine designer drugs in differentiated human neuroblastoma SH-SY5Y cells". Journal of Applied Toxicology 36 1 (2016): 121-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952636464&partnerID=MN8TOARS.
    Published • 10.1002/jat.3153
  26. Barbosa, Daniel José (FE1C-104F-37C1); Capela, J.P.; Feio-Azevedo, R.; Teixeira-Gomes, A.; Bastos, M.L.; Carvalho, F.. "Mitochondria: key players in the neurotoxic effects of amphetamines". Archives of Toxicology 89 10 (2015): 1695-1725. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942195353&partnerID=MN8TOARS.
    Published • 10.1007/s00204-015-1478-9
  27. Silva, R.; Palmeira, A.; Carmo, H.; Gameiro, M.; Gomes, A.; Paiva, A.M.; Sousa, E.; et al. "P-glycoprotein induction in Caco-2 cells by newly synthetized thioxanthones prevents paraquat cytotoxicity". Archives of Toxicology 89 10 (2015): 1783-1800. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942198190&partnerID=MN8TOARS.
    Published • 10.1007/s00204-014-1333-4
  28. Silva, R.; Carmo, H.; Vilas-Boas, V.; Barbosa, Daniel José (FE1C-104F-37C1); Monteiro, M.; de Pinho, P.G.; de Lourdes Bastos, M.; Remião, F.. "Several transport systems contribute to the intestinal uptake of Paraquat, modulating its cytotoxic effects". Toxicology Letters 232 1 (2015): 271-283. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911457479&partnerID=MN8TOARS.
    Published • 10.1016/j.toxlet.2014.10.015
  29. Barbosa, Daniel José (FE1C-104F-37C1); Capela, J.P.; De Lourdes Bastos, M.; Carvalho, F.. "In vitro models for neurotoxicology research". Toxicology Research 4 4 (2015): 801-842. http://www.scopus.com/inward/record.url?eid=2-s2.0-84935015349&partnerID=MN8TOARS.
    Published • 10.1039/c4tx00043a
  30. Barbosa, Daniel José (FE1C-104F-37C1); Serrat, R.; Mirra, S.; Quevedo, M.; de Barreda, E.G.; Àvila, J.; Luísa Maria Ferreira; et al. "The mixture of "ecstasy" and its metabolites impairs mitochondrial fusion/fission equilibrium and trafficking in hippocampal neurons, at in vivo relevant concentrations". Toxicological Sciences 139 2 (2014): 407-420. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899939292&partnerID=MN8TOARS.
    Published • 10.1093/toxsci/kfu042
  31. Barbosa, Daniel José (FE1C-104F-37C1); Serrat, R.; Mirra, S.; Quevedo, M.; Gómez De Barreda, E.; Ávila, J.; Fernandes, E.; et al. "MDMA impairs mitochondrial neuronal trafficking in a Tau- and Mitofusin2/Drp1-dependent manner". Archives of Toxicology 88 8 (2014): 1561-1572. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905002125&partnerID=MN8TOARS.
    Published • 10.1007/s00204-014-1209-7
  32. Arbo, M.D.; Silva, R.; Barbosa, Daniel José (FE1C-104F-37C1); da Silva, D.D.; Rossato, L.G.; Bastos, M.D.L.; Carmo, H.. "Piperazine designer drugs induce toxicity in cardiomyoblast h9c2 cells through mitochondrial impairment". Toxicology Letters 229 1 (2014): 178-189. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903629417&partnerID=MN8TOARS.
    Published • 10.1016/j.toxlet.2014.06.031
  33. Barbosa, Daniel José (FE1C-104F-37C1); Capela, J.P.; Silva, R.; Ferreira, L.M.; Branco, P.S.; Fernandes, E.; Bastos, M.L.; Carvalho, F.. "Ecstasy-induced toxicity in SH-SY5Y differentiated cells: Role of hyperthermia and metabolites". Archives of Toxicology 88 2 (2014): 515-531. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893906917&partnerID=MN8TOARS.
    Published • 10.1007/s00204-013-1147-9
  34. Barbosa, Daniel José (FE1C-104F-37C1); Capela, J.P.; Silva, R.; Vilas-Boas, V.; Ferreira, L.M.; Branco, P.S.; Fernandes, E.; Bastos, M.D.L.; Carvalho, F.. "The mixture of "ecstasy" and its metabolites is toxic to human SH-SY5Y differentiated cells at in vivo relevant concentrations". Archives of Toxicology 88 2 (2014): 455-473. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893949148&partnerID=MN8TOARS.
    Published • 10.1007/s00204-013-1120-7
  35. Silva, R.; Carmo, H.; Vilas-Boas, V.; Barbosa, Daniel José (FE1C-104F-37C1); Palmeira, A.; Sousa, E.; Carvalho, F.; De Lourdes Bastos, M.; Remião, F.. "Colchicine effect on P-glycoprotein expression and activity: In silico and in vitro studies". Chemico-Biological Interactions 218 (2014): 50-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901254592&partnerID=MN8TOARS.
    Published • 10.1016/j.cbi.2014.04.009
  36. Silva, R.; Sousa, E.; Carmo, H.; Palmeira, A.; Barbosa, Daniel José (FE1C-104F-37C1); Gameiro, M.; Pinto, M.; De Lourdes Bastos, M.; Remião, F.. "Induction and activation of P-glycoprotein by dihydroxylated xanthones protect against the cytotoxicity of the P-glycoprotein substrate paraquat". Archives of Toxicology 88 4 (2014): 937-951. http://www.scopus.com/inward/record.url?eid=2-s2.0-84897110064&partnerID=MN8TOARS.
    Published • 10.1007/s00204-014-1193-y
  37. Barbosa, Daniel José (FE1C-104F-37C1); Serrat, Romàn; Ferreira, Luísa Maria; Branco, Paula Sério; Bastos, Maria de Lourdes; Capela, João Paulo; Soriano, Eduardo; Carvalho, Félix. "Neuronal Mitochondrial Trafficking Impairment: The Cause or a Consequence of Neuronal Dysfunction Caused by Amphetamine-Like Drugs". Journal of Drug and Alcohol Research 3 (2014): 1-7. http://dx.doi.org/10.4303/jdar/235868.
    Published • 10.4303/jdar/235868
  38. Barbosa, Daniel José; Capela, João Paulo; Oliveira, Jorge MA; Silva, Renata; Ferreira, Luísa Maria; Siopa, Filipa; Branco, Paula Sério; et al. "Pro-oxidant effects of Ecstasy and its metabolites in mouse brain synaptosomes". British Journal of Pharmacology 165 4b (2012): 1017-1033. https://doi.org/10.1111/j.1476-5381.2011.01453.x.
    10.1111/j.1476-5381.2011.01453.x
Journal issue
  1. Sobral, Ana Filipa; Barbosa, DJ. "Molecular motors in neuronal homeostasis and neurodegeneration". Brain Sciences (2025): https://www.mdpi.com/journal/brainsci/special_issues/M6L3X70WW5.
    In press • Invited editor
  2. Barbosa, Daniel José; Silva, Renata. "Molecular and cellular advances on drug discovery, pharmacology and toxicology, 2nd Edition". Medicina (2025): https://www.mdpi.com/journal/medicina/special_issues/9BI035U1YQ.
    In press • Invited editor
  3. Barbosa, Daniel José; Renata Silva. "The intersection of drug abuse, neurotoxicity and neurodegenerative diseases". International Journal of Molecular Sciences (2025): https://www.mdpi.com/journal/ijms/special_issues/4QNY3F411K.
    In press • Invited editor
  4. Patrícia Silva; Barbosa, Daniel José; Elaine Maria Souza-Fagundes. "The (un)desirability of cell death in health and disease: Emerging modulators and their mechanisms". Frontiers in Cell and Development Biology (2024): https://www.frontiersin.org/research-topics/57035/the-undesirability-of-cell-death-in-health-and-disease-emerging-modulators-and-their-mechanisms.
    Coeditor
  5. Barbosa, Daniel José; Liliana Luz. "Mechanisms of myelin misregulation and neuronal dysfunction in demyelinating diseases". Frontiers in Neurology (2023): https://www.frontiersin.org/research-topics/49012/mechanisms-of-myelin-misregulation-and-neuronal-dysfunction-in-demyelinating-diseases.
    Editor
  6. Barbosa, Daniel José; Silva, Renata. "Molecular and Cellular Advances on Drug Discovery, Pharmacology and Toxicology". Medicina (2022): https://www.mdpi.com/journal/medicina/special_issues/drug_discovery_pharmacology_and_toxicology.
    Published • Editor
  7. Silva, Renata; Barbosa, Daniel José. "New Insights on Drug Design, Delivery and Targeting in Neurodegeneration". Pharmaceutics (2022): https://www.mdpi.com/journal/pharmaceutics/special_issues/drug_neurodegeneration.
    Published • Coeditor
Preprint
  1. Cátia Carvalho; Barbosa, Daniel José; Ricardo Celestino; Esther Zanin; Ana Xavier Carvalho; Reto Gassmann. "Dynein directs prophase centrosome migration to control the stem cell division axis in the developing C. elegans epidermis". 2023. https://doi.org/10.1101/2023.09.25.559295.
    10.1101/2023.09.25.559295
  2. Sobral, A.F.; Chan, F.-Y.; Ferreira, V.; Osório, D.S.; Barbosa, D.J.; Cheerambathur, D.; Gassmann, R.; Xavier de Carvalho, A.. "Plastin and Heavy-Spectrin Cooperate to Stabilize the Actomyosin Cortex during Cytokinesis". 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85110755737&partnerID=MN8TOARS.
    10.2139/ssrn.3779552
  3. Celestino, R.; Gama, J.B.; Castro-Rodrigues, A.F.; Barbosa, D.J.; D'Amico, E.A.; Musacchio, A.; Carvalho, A.X.; Morais-Cabral, J.H.; Gassmann, R.. "JIP3 regulates bi-directional organelle transport in neurons through its interaction with dynein and kinesin-1". 2021. http://www.scopus.com/inward/record.url?eid=2-s2.0-85119831780&partnerID=MN8TOARS.
    10.1101/2021.10.11.463801
  4. Barbosa, Daniel José. "Dynein-dynactin segregate meiotic chromosomes in C. elegans spermatocytes". 2020. http://dx.doi.org/10.1101/2020.10.19.345041.
    10.1101/2020.10.19.345041
  5. Barbosa, D.J.; Duro, J.; Cheerambathur, D.K.; Prevo, B.; Carvalho, A.X.; Gassmann, R.. "Dynactin binding to tyrosinated microtubules promotes centrosome centration in C. elegans by enhancing dynein-mediated organelle transport". 2017. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095637707&partnerID=MN8TOARS.
    10.1101/130104
Thesis / Dissertation
  1. José Barbosa, Daniel. "Ecstasy´s Neurotoxicity: In Vitro Findings from Mitochondria to the Cell". PhD, Universidade do Porto Faculdade de Farmácia, 2013. https://hdl.handle.net/10216/71861.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/05/03 The effect of synthetic cannabinoid ADB-FUBINACA on primary neuronal cultures ß-galactosidase activity: preliminary findings III 1H-TOXRUN INTERNATIONAL CONGRESS
1H-TOXRUN RESEARCH UNIT - IUCS - CESPU (Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/12/01 - Current The influence of ketamine on C. elegans behaviour
Supervisor of Diogo Alexandre Marques
 Ciências Forenses (Master)
Instituto Universitário de Ciências da Saúde, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2024/10/01 - Current Toxicological interactions of synthetic cathinones and ethanol in the C. elegans animal model
Supervisor
 Ciências Forenses (Degree)
Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal

Instituto Universitário de Ciências da Saúde, Portugal
2024/10/01 - Current Herbicide risk assessment in C. elegans and toxicological implications for humans
Supervisor of Joana Beatriz Machado Sampaio Pinto
 Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2024/10/01 - Current Toxicology of ketamine in the C. elegans animal model
Supervisor
 Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2024/09/01 - Current Impact of synthetic cathinones on C. elegans development, locomotion and reproductive behaviors, and lifespan
Co-supervisor of Mariana Almeida Lopes
 Ciências Forenses (Master)
Instituto Universitário de Ciências da Saúde, Portugal

Instituto Universitário de Ciências da Saúde Unidade de Investigacao em Toxicologia, Portugal
2024/03/01 - Current Culturomic and biochemical analysis of bacterial indicators for Postmortem Interval calculation
Co-supervisor
 Ciências Forenses (Master)
Universidade do Porto Faculdade de Medicina, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/12/09 Unravelling the neurotoxicity of synthetic cathinones in a neuritogenesis model
(Thesis) Main arguer
 Catarina Teixeira da Fonseca (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2024/11/14 Study on individuals using/dependent on cocaine/crack evaluated in the Psychiatry Department of the Forensic Medicine Institute of Paraná
(Thesis) Main arguer
 Rodrigo Pirard Basso (Master)
Universidade do Porto Faculdade de Medicina, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2024/06/11 - 2024/12/29 Antioxidants & Redox Signaling (1523-0864) Mary Ann Liebert, Inc Publishers
2024/12/06 - 2024/12/26 Nutrients (2072-6643) MDPI
2024/12/20 - 2024/12/21 Antioxidants (2076-3921) MDPI
2024/12/04 - 2024/12/06 Scientific Letters (2795-5117) IUCS - CESPU
2024/12/05 - 2024/12/05 Current Forensic Science (2666-4844) Bentham Science
2024/11/18 - 2024/12/05 Nutrients (2072-6643) MDPI
2024/11/04 - 2024/11/29 International Journal of Molecular Sciences (1422-0067) MDPI
2024/11/07 - 2024/11/24 Nutrients (2072-6643) MDPI
2024/11/11 - 2024/11/15 FEBS Journal (1742-464X) Wiley Online Library
2024/10/29 - 2024/11/14 Internatinal Journal of Molecular Sciences (1422-0067) MDPI
2024/09/04 - 2024/11/13 Current Medical Chemistry (1875-533X) Bentham Science
2024/11/08 - 2024/11/12 Scientific Reports (2045-2322) Nature Portfolio
2024/11/05 - 2024/11/07 MedComm (2688-2663) John Wiley & Sons Inc.
2024/10/18 - 2024/11/05 Antioxidants (2076-3921) MDPI
2024/10/23 - 2024/10/24 Nutrients (2072-6643) MDPI
2024/10/09 - 2024/10/22 Nutrients (2072-6643) MDPI
2024/10/21 - 2024/10/21 Journal of Alzheimer's Disease (1875-8908) IOS Press
2024/10/11 - 2024/10/18 Basic and Clinical Pharmacologya and Toxicology (1742-7843) Wiley Online Library
2024/10/17 - 2024/10/17 Internatinal Journal of Molecular Sciences (1422-0067) MDPI
2024/09/27 - 2024/10/16 Antioxidants (2076-3921) MDPI
2024/10/03 - 2024/10/11 Nutrients (2072-6643) MDPI
2024/09/20 - 2024/10/04 Nutrients (2072-6643) MDPI
2024/10/01 - 2024/10/02 Journal of Alzheimer's Disease (1875-8908) IOS Press
2024/09/28 - 2024/09/30 Proceedings of the National Academy of Sciences of the United States of America (0027-8424) National Academy of Sciences
2024/09/19 - 2024/09/29 Frontiers in Immunology (1664-3224) Frontiers
2024/09/18 - 2024/09/19 Internatinal Journal of Molecular Sciences (1422-0067) MDPI
2024/07/27 - 2024/08/21 Internatinal Journal of Molecular Sciences (1422-0067) MDPI
2024/07/17 - 2024/08/21 Internatinal Journal of Molecular Sciences (1422-0067) MDPI
2024/05/02 - 2024/08/08 Current Medical Chemistry (1875-533X) Bentham Science
2024/07/25 - 2024/08/06 Internatinal Journal of Molecular Sciences (1422-0067) MDPI
2024/08/01 - 2024/08/02 Neurotoxicology (0161-813X) Elsevier
2024/07/09 - 2024/07/25 Antioxidants (2076-3921) MDPI
2024/07/17 - 2024/07/18 Internatinal Journal of Molecular Sciences (1422-0067) MDPI
2024/06/19 - 2024/07/15 Internatinal Journal of Molecular Sciences (1422-0067) MDPI
2024/07/12 - 2024/07/14 Internatinal Journal of Molecular Sciences (1422-0067) MDPI
2024/07/05 - 2024/07/07 Internatinal Journal of Molecular Sciences (1422-0067) MDPI
2024/07/03 - 2024/07/04 Internatinal Journal of Molecular Sciences (1422-0067) MDPI
2024/06/28 - 2024/07/01 International Journal of Molecular Sciences (1422-0067) MDPI
2024/06/26 - 2024/06/27 Journal of Alzheimer Disease (1875-8908) IOS Press
2024/06/24 - 2024/06/26 Internatinal Journal of Molecular Sciences (1422-0067) MDPI
2024/06/11 - 2024/06/24 Basic and Clinical Pharmacology and Toxicology (1742-7843) Wiley Online Library
2024/06/12 - 2024/06/22 Antioxidants (2076-3921) MDPI
2024/06/18 - 2024/06/20 MedComm (2688-2663) John Wiley & Sons Inc.
2024/05/15 - 2024/06/11 Neurotoxicology (0161-813X) Science Direct
2024/03/22 - 2024/06/11 Current Medical Chemistry (1875-533X) Bentham Science
2024/05/31 - 2024/05/31 International Journal of Molecular Sciences (1422-0067) MDPI
2024/05/24 - 2024/05/27 Frontiers in Neuroscience (1662-453X) Frontiers
2024/05/13 - 2024/05/26 Antioxidants (2076-3921) MDPI
2024/05/24 - 2024/05/24 Antioxidants (2076-3921) MDPI
2024/05/21 - 2024/05/22 Antioxidants & Redox Signaling (1523-0864) Mary Ann Liebert, Inc Publishers
2024/05/20 - 2024/05/21 Journal of Personalized Medicine (2075-4426) MDPI
2024/03/04 - 2024/05/16 International Journal of Molecular Sciences (1422-0067) MDPI
2024/03/20 - 2024/05/13 Molecular Neurobiology (1559-1182) Springer
2024/04/30 - 2024/05/08 Antioxidants (2076-3921) MDPI
2024/04/23 - 2024/05/06 International Journal of Molecular Sciences (1422-0067) MDPI
2024/04/05 - 2024/04/30 Psychoactives (2813-1851) MDPI
2024/04/09 - 2024/04/28 Antioxidants (2076-3921) MDPI
2024/04/25 - 2024/04/25 Pharmaceuticals (1424-8247) MDPI
2024/03/11 - 2024/04/22 Current Medical Chemistry (1875-533X) Bentham Science
2024/02/26 - 2024/04/02 Alzeimer's Research & Therapy (1758-9193) BioMed Central
2024/03/28 - 2024/04/01 International Journal of Molecular Sciences (1422-0067) MDPI
2024/03/22 - 2024/03/29 Current Medical Chemistry (1875-533X) Bentham Science
2024/03/22 - 2024/03/29 International Journal of Molecular Sciences (1422-0067) MDPI
2024/03/12 - 2024/03/25 Molecular Neurobiology (1559-1182) Springer
2024/03/18 - 2024/03/20 Antioxidants & Redox Signaling (1557-7716) Mary Ann Liebert, Inc Publishers
2024/03/18 - 2024/03/20 Pharmaceuticals (1424-8247) MDPI
2024/03/14 - 2024/03/14 Antioxidants (2076-3921) MDPI
2024/02/26 - 2024/03/13 Genes (2073-4425) MDPI
2024/02/23 - 2024/03/11 Artificial Inteligence in Health (3029-2387) AccScience Publishing
2024/03/07 - 2024/03/07 International Journal of Molecular Sciences (1422-0067) MDPI
2024/02/12 - 2024/02/13 Journal of Personalized Medicine (2075-4426) MDPI

Association member

Society Organization name Role
2024/11 - Current Portuguese Association of Forensic Sciences Associate member

Conference scientific committee

Conference name Conference host
2024/05/02 - 2024/05/03 III 1H-TOXRUN International Congress 2024 1H-TOXRUN Research Unit - IUCS - CESPU

Other jury / evaluation

Activity description Institution / Organization
2024/06/04 - 2024/06/04 Metabolism of mCPP, trazodone, nefazodone and etoperidone: Clinical and forensic aspects Universidade do Porto Faculdade de Medicina, Portugal
2024/03/08 - 2024/03/08 Using solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) as a smart approach to improve the treatment of acute migraine via the nose-brain route Universidade do Porto Faculdade de Farmácia, Portugal
2023/09/04 - 2023/09/04 Pharmacokinetics and pharmacodynamics of gabapentin: Clinical and forensic features of abuse Universidade do Porto Faculdade de Medicina, Portugal
Distinctions

Award

2024 Annual scientific productivity award
Instituto Universitário de Ciências da Saúde, Portugal