Ester Sofia Teixeira Benfeito (FF11-B5DB-BA39)

Curriculum Vitae

Ester Sofia Teixeira Benfeito

Sofia Benfeito (SB) graduated in Chemistry in 2010 at Faculty of Sciences of University of Porto (FCUP) and received her M.Sc. in Chemistry in 2012 in the same institution. In July 2018, she completed her Ph.D. in Pharmaceutical Sciences, Toxicology speciality, at the Faculty of Pharmacy of the University of Porto, which was titled as European Doctorate. Her Ph.D. thesis was focused on the design and development of multi-target agents based on naturally occurring scaffolds for neurodegenerative diseases, such as Alzheimer's (AD). During her Ph.D., she improved and solidified knowledge related with the synthesis and structural characterization of bioactive compounds. She also acquired experience in biological screenings in cell-based and cell free systems (e.g.: antioxidant activity, cytotoxicity, enzyme inhibition, permeability studies), in mitochondrial uptake assays in Rat Liver Mitochondria and in monitoring bioenergetics of mitochondria and live cells in real time using Seahorse XFe96 Extracellular Flux Analyzer. The work developed was considered a major breakthrough and she was also internationally awarded by Paul Ehrlich European MedChem Network-PhD Label (Italy, 2019). Currently, as Junior Researcher, she is engaged in the synthesis of new chemical entities for phenotypic/target-based screenings and in the optimization of lead compounds to develop pharmacologically viable candidates. SB is the Principal Investigator of an Awarded FCT Project, which started in March 2023, "DeFend - De-ironing Friedreich's Ataxia with innovative mitochondria-targeted chelators" (2022.04633.PTDC),project with the collaboration of Dr. António Currais (Salk Institute, USA), and the Co-Principal Investigator of the Awarded FCT Project, from February 2022 to July 2023, "NOXIous - Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure" (EXPL/BIA-BQM/0492/2021), project with the collaboration of Professor Andrea Mattevi (UniPV, Italy). SB participated as a Researcher in other numerous funded R&D projects, from which resulted 31 peer-reviewed publications in international high impact factor journals (10 as first author, 2 as corresponding author, 86% in Q1), 7 book chapters, 92 communications in Poster, 47 Oral communications, as well as 35 abstracts in conference proceedings. The citation count from Scopus is a total of 420 resulting in an h-index of 10. Moreover, she was also co-inventor of 1 international patent (PCT/IB2017/056412; US20190248816), which the commercial exploitation was licensed to the MitoTAG spin-off company (2017). SB attended with full grants 3 international training schools: the European School of Medicinal Chemistry (Italy, 2016), the MuTaLig COST Action CA15135 Multi-Targeting Biophysical Training School (Germany, 2018) and Summer School in Pharmaceutical Analysis (Italy 2021). In addition to her research activities, she participated as invited Professor in Medicinal Chemistry and Bioorganic Chemistry classes and supervised several students in PhD Thesis, Project (Chemistry and Biochemistry BSc) and Dissertation (Chemistry MSc) classes (18 students in total). Over the last 5 years, SB was actively involved in science dissemination activities and established national/international collaborations with 23 groups that can add value to her current research activities.

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Identification

Personal identification

Full name: Ester Sofia Teixeira Benfeito

Citation names

Benfeito, Ester
Benfeito, S.
Benfeito, Sofia

Author identifiers

Ciência ID: FF11-B5DB-BA39
ORCID iD: 0000-0001-9645-8152
AuthenticusID: ID: R-001-VKN
Google Scholar ID: Sofia Benfeito
Researcher Id: N-9418-2017
Scopus Author Id: 55151147600

Email addresses

ester.benfeito@fc.up.pt (Professional)

Addresses

Faculdade de Ciências da Universidade do Porto. Rua do Campo Alegre s/n, 4169-007, Porto, Porto, Portugal (Professional)

Websites

https://drugdiscoveryup.pt/ (Professional)
https://pt.linkedin.com/in/sofia-benfeito-01a8a45b (Social media)
https://www.researchgate.net/profile/Sofia-Benfeito (Social media)
https://www.scopus.com/authid/detail.uri?authorId=55151147600 (Professional)

Knowledge fields

Exact Sciences - Chemical Sciences - Organic Chemistry
Medical and Health Sciences - Basic Medicine - Toxicology
Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
Medical and Health Sciences - Clinical Medicine
Medical and Health Sciences - Health Sciences - Health Care Sciences and Services

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
French	Elementary (A2)	Elementary (A2)	Elementary (A2)	Elementary (A2)	Elementary (A2)

Education

	Degree	Classification
2021/09/22 - 2021/09/24 Attended	Summer School in Pharmaceutical Analysis (Outros) Major in Analytical methods to achieve efficiency in the hit-to-lead process Università degli Studi di Bologna, Italy
2018/12/05 - 2018/12/07 Attended	3rd MuTaLig Training School - Cost Action multi-targeting biophysical training school (Outros) Fraunhofer-Verbund IUK-Technologie, Germany
2014/03/01 - 2018/07/16 Concluded	PhD in Pharmaceutical Sciences (Doutoramento) Major in Toxicology Specialty Universidade do Porto Faculdade de Farmácia, Portugal "Design and development of multi-target agents for neurodegenerative diseases" (THESIS/DISSERTATION)	Unanimously approved
2016/06/26 - 2016/07/01 Attended	Training School - 36 th Edition of European School of Medicinal Chemistry (ESMEC) (Outros) Campus “Collegi del Colle e Tridente”, Italy
2010/09/01 - 2012/10/03 Concluded	MSc in Chemistry (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal ""Desenvolvimento de novos antioxidantes lipofílicos baseado no ácido cinâmico"" (THESIS/DISSERTATION)	16/20
2006/09/01 - 2010/07/13 Concluded	1st Degree in Chemistry (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal "Quality control of port wine and study of the evolution of the levels of calcium, potassium and copper along the aging process by atomic absorption spectroscopy." (THESIS/DISSERTATION)	13/20

Affiliation

Science

	Category Host institution	Employer
2024 - Current	Contracted Researcher (Research)	Universidade do Porto Faculdade de Ciências, Portugal
	Universidade do Porto Centro de Investigação em Química, Portugal
2018 - Current	Visiting Researcher (Research)	REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
	Universidade do Porto Faculdade de Farmácia, Portugal
2018/12/01 - 2024/03/07	Contracted Researcher (Research)	Universidade do Porto Faculdade de Ciências, Portugal
	Universidade do Porto Centro de Investigação em Química, Portugal
2019/09/02 - 2020/03/06	Visiting Researcher (Research)	Università degli Studi Magna Graecia di Catanzaro, Italy
	Universidade do Porto Centro de Investigação em Química, Portugal
2014/10/06 - 2017/09/29	Visiting Researcher (Research)	Universidade de Santiago de Compostela Facultad de Farmacia, Spain

2017/05/01 - 2017/08/31	Visiting Researcher (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

2011/03/02 - 2011/11/02	Research Trainee (Research)	Universidade do Porto Centro de Investigação em Química, Portugal
	Universidade do Porto Faculdade de Ciências, Portugal

Others

	Category Host institution	Employer
2018/05/16 - 2018/12/01	Research grant in the project: "Sustainable Advanced Materials (SAM)¿ (NORTE-01-0145-FEDER-000028)	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Porto Faculdade de Ciências, Portugal (...)
2014/03/01 - 2018/03/01	PhD student, FCT Grant (SFRH/BD/99189/2013)	Fundação para a Ciência e a Tecnologia, Portugal
	Universidade do Porto Faculdade de Ciências, Portugal (...)
2012/11/02 - 2013/11/02	Research grant in the project: "NanoPest - Nanotecnologia Aplicada aos Pesticida (PTDC/AGR-AAM/105044/2008)	Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal
	Universidade do Porto Centro de Investigação em Química, Portugal
2011/12/05 - 2012/03/06	Erasmus training period	Universidade de Santiago de Compostela Facultad de Farmacia, Spain

Projects

Grant

	Designation	Funders
2018/05/16 - 2018/12/01	Sustainable Advanced Materials (SAM) NORTE-01-0145-FEDER-000028 Master Student Fellow Universidade do Porto Faculdade de Ciências, Portugal	Comissao de Coordenacao e Desenvolvimento Regional do Norte Fundação para a Ciência e a Tecnologia Concluded
2014/03 - 2018/02	Design and development of multi-target agents for neurodegenerative diseases SFRH/BD/99189/2013 PhD Student Fellow	Fundação para a Ciência e a Tecnologia Concluded
2012/11/02 - 2013/11/02	NanoPest - Nanotecnologia Aplicada aos Pesticidas PTDC/AGR-AAM/105044/2008 Master Student Fellow Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2024 - Current	IMPULSE: IMProving User experience, Long-term sustainability and Services of EU-OPENSCREEN 101132028 Post-doc Universidade do Porto Faculdade de Ciências, Portugal	European Research Executive Agency Ongoing
2022/03/01 - 2023/06/30	PT-OPENSCREEN - NORTE-01-0145-FEDER-085468: “Infraestrutura Nacional para a Química Biológica e Genética” NORTE-01-0145-FEDER-085468 Post-doc Universidade do Porto, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal Universidade do Minho, Portugal Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Instituto Nacional de Engenharia Biomédica, Portugal	Comissao de Coordenacao e Desenvolvimento Regional do Norte Ongoing
2019/12/01 - 2022/01/31	COMT4BRAIN: Development of centrally-active and safe catechol O-methyltransferase inhibitors POCI-01-0145-FEDER-029164 Post-doc Universidade do Porto Faculdade de Medicina, Portugal Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/12/01 - 2019/11/29	SkinSHIELD 2: Redox-active phytochemicals triggering mitochondrial hormesis: developing a new generation of cosmetic active ingredients POCI-01-0145-FEDER-028607 Post-doc Universidade do Porto Faculdade de Ciências, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Other

	Designation	Funders
2023 - Current	DeFend: De-ironing Friedreich¿s Ataxia with innovative mitochondria-targeted chelators 2022.04633.PTDC Principal investigator Universidade do Porto Centro de Investigação em Química, Portugal Universidade do Porto Faculdade de Ciências, Portugal Salk Institute for Biological Studies, United States	Fundação para a Ciência e a Tecnologia Ongoing
2023 - Current	MitoTARGET4AD: Improving Nature for a Novel Disruptive Treatment for Alzheimer's Disease 2022.15117.CBM Post-Doc Team member Universidade do Porto Faculdade de Ciências, Portugal Université de Montpellier, France	Fundação para a Ciência e a Tecnologia Concluded
2022 - Current	NeuroTool4ALS: Human Neuronal Cells Differentiated from Urine-derived Stem Cells as a Platform for Personalized Medicine in Amyotrophic Lateral Sclerosis PTDC/BTM-ORG/0055/2021 Post-Doc Team member Universidade do Porto Faculdade de Ciências, Portugal universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2021/01/01 - Current	Plurianual Funding of the Associated Laboratory Institute of Molecular Sciences LA/P/0056/2020 Post-Doc Team member Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2020/01/01 - Current	CIQUP - Financiamento Plurianual da Unidade de I&D CIQUP - Centro de Investigação em Química da Universidade do Porto UIDB/00081/2020 Post-Doc Team member Universidade do Porto Centro de Investigação em Química, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2024 - 2028	European Network for Sigma-1 Receptor as a Therapeutic Opportunity (SIGMA-1EUROPE) CA23156 Post-doc Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022/02/01 - 2023/07/31	NOXIous- Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure EXPL/BIA-BQM/0492/2021 Co-Principal Investigator (Co-PI) Universidade do Porto Centro de Investigação em Química, Portugal Universidade do Porto Faculdade de Ciências, Portugal Università degli Studi di Pavia Dipartimento di Biologia e Biotecnologie L. Spallanzani, Italy	Fundação para a Ciência e a Tecnologia Concluded
2022/01/01 - 2023/06/30	Role of mitochondrial-thiol homeostasis in neurodegeneration: implication for amyotrophic lateral sclerosis EXPL/BTM-TEC/1407/2021 Post-Doc Team member Universidade do Porto Faculdade de Ciências, Portugal universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2022/07/01 - 2023/06	MitoBOOST v2.0 - Prova de Conceito para o Uso de Polifenóis Dirigidos à Mitocôndria para Tratar a Doença do Fígado Gordo Não-Alcoólico 181226 Post-Doc Team member Universidade do Porto Faculdade de Ciências, Portugal universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Comissão de Coordenação e Desenvolvimento Regional do Centro Concluded
2018/07/01 - 2022/05/01	Mito4ALS -Development of Novel Mitochondria-Targeted Antioxidants for Improving SOD1-Familial Amyotrophic Lateral Sclerosis Phenotype POCI-01-0145-FEDER-029391 Post-Doc Team member Universidade do Porto Faculdade de Ciências, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/01/01 - 2022/05/01	ABFish -Development of new antibiotics for aquaculture POCI-01-0145-FEDER-028397 Post-Doc Team member Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Faculdade de Engenharia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/06/06 - 2021/06/05	BIOFILM-Development of novel biocide solutions for effective biofilm control POCI-01-0145-FEDER-030219 Post-Doc Team member Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Faculdade de Engenharia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2018/07 - 2020/10	Multi-target paradigm for innovative ligand identification in the drug discovery process (MuTaLig) CA COST Action CA15135 OC-2016-2-21500 Post-Doc Team member	European Union Concluded
2015/09/01 - 2018/02/28	TOX-OER - Learning Toxicology through Open Educational Resources 2015-1-ES01-KA203-015957 Colaboration Universidade do Porto Faculdade de Farmácia, Portugal	Erasmus Plus Concluded
2017 - 2017	MitoBOOST: A Next-Generation Therapeutics for Non-Alcoholic Fatty Liver Disease Based on Smart Antioxidant Delivery to Mitochondria PTDC/DTP-FTO/2433/2014 PhD Student Fellow Universidade do Porto Faculdade de Ciências, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2016 - 2016	Centro de Investigação em Química da Universidade UID/QUI/00081/2013 PhD Student Fellow Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Centro de Investigação em Química, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2015 - 2015	Development of functional materials NORTE-07-0124-FEDER-000065 PhD Student Fellow Universidade do Porto Centro de Investigação em Química, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2014/03/01 - 2014/12/31	Projecto Estratégico - LA 1 - 2013-2014 PEst-C/SAU/LA0001/2013 PhD Student Fellow Universidade do Porto Centro de Investigação em Química, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013 - 2014	Projecto Estratégico – UI81-2013-2014 PEst-C/QUI/UI0081/2013 PhD Student Fellow Universidade do Porto Faculdade de Ciências, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2012 - 2012	Environmentally friendly active films based on chitosan PP_IJUP2011 208 Technical development Universidade do Porto, Portugal	Universidade do Porto Concluded
2012 - 2012	Formulação de uma bebida funcional à base de extrato natural purificado de Spergularia rubra PP-IJUP2011-UNICER- 84 Technical development Universidade do Porto, Portugal	Universidade do Porto Faculdade de Ciências Banco Santander Portugal Concluded
2011 - 2011	Fine-tuning the hydrophobicity of natural antioxidants: development of innovative mitochondria-targeted antioxidants based on benzoic acid scaffold PP_IJUP2011 209 Technical development Universidade do Porto, Portugal	Universidade do Porto Concluded

Outputs

Publications

Book chapter	Silva, C.; Pinto, M.; Fernandes, C.; Benfeito, S.; Borges, F.. "Antioxidant therapy and neurodegenerative disorders: lessons from clinical trials". In Systems Medicine: Integrative, Qualitative and Computational Approaches, edited by Olaf Wolkenhauer. Porto, Portugal: Elsevier, 2020. Published • 10.1016/B978-0-12-801238-3.11611-3 Pinto, M.; Benfeito, S.; Fernandes, C.; Borges, F.. "Antioxidant therapy, oxidative stress, and blood-brain barrier: The road of dietary antioxidants". In Oxidative Stress and Dietary Antioxidants in Neurological Diseases, edited by Victor R. Preedy, 125-141. Porto, Portugal: Academic Press- Elsevier Science, 2019. Published • 10.1016/B978-0-12-817780-8.00009-8 Fernandes, Carlos; Benfeito, Sofia; Fonseca, André; Oliveira, Catarina; Garrido, Jorge; Garrido, E. Manuela; Borges, Fernanda. "Photodamage and photoprotection: toward safety and sustainability through nanotechnology solutions". In Food Preservation, edited by Alexandru Grumezescu, 527-565. Porto, Portugal: Elsevier, 2018. Published • 10.1016/b978-0-12-804303-5.00015-8 Amorim, Ricardo; Benfeito, Sofia; Teixeira, José; Cagide, Fernando; Oliveira, Paulo J.; Borges, Fernanda. "Targeting Mitochondria: The Road to Mitochondriotropic Antioxidants and Beyond". In Mitochondrial Biology and Experimental Therapeutics, edited by Oliveira, P.J., 333-358. Porto, Portugal: Springer International Publishing, 2018. Published • 10.1007/978-3-319-73344-9_16 Benfeito, S.; Silva, T.; Garrido, E.M.; Borges, F.; Garrido, J.. "Synthesis of lipophilic antioxidants based on natural models". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom, edited by Carlos A. M. Afonso; Robert Franzén; Bin Tanc; Dulce Simão; Alexandre Trindade; Jaime Coelho; Nuno R. Candeias, 380-386. Porto, Portugal: Royal Chemical Society, 2016. Published • 978-1-84973-963-4 Teixeira, José; Soares, Pedro; Benfeito, Sofia; Murphy, Michael P.; Oliveira, Paulo J.; Borges, Fernanda. "Bridging the Gap Between Nature and Antioxidant Setbacks: Delivering Caffeic Acid to Mitochondria". In Methods in Molecular Biology, 73-83. Springer New York, 2015. Published • 10.1007/978-1-4939-2288-8_6 Benfeito, S.; Garrido, J.; Sottomayor, M.J.; Borges, F.; Manuela Garrido, E.. "Pesticides and cancer: Studies on the interaction of phenoxy acid herbicides with DNA". In handbook on herbicides: Biological Activity, Classification and Health & Environmental Implications, edited by Kobayashi, D.; Watanabe, E., 246-261. Porto, Portugal: Nova Science Publishers, Inc., 2014. Published • 978-1-62948-053-4
Conference abstract	Mena, D.; Cagide, F.; Benfeito, S.; Soares, P.; Grilo, L.; Pinheiro, P.; Teixeira, J.; et al. "The mitochondria-targeted antioxidant AntiOxCIN4 protects against cardiac oxidative/nitrosative stress in the amyotrophic lateral sclerosis SOD1G93A mouse". Paper presented in 57th ESCI 2023 Annual Scientific Meeting of the European Society for Clinical Investigation, Praga, 2023. Accepted I. Costa; Benfeito, S.; V. Silva; F. Cagide; F. Borges; F. Remião; R. Silva. "Neuroprotective effects of mitochondria-targeted antioxidants in a Parkinson’s disease in vitro model". Paper presented in II TOXRUN International Congress 2023, Porto, 2023. Published • 2795-5117 Silva, V.; Benfeito, S.; Lima, C.; Chavarria, D.; Gonçalves, T.; Costa, I.; Remião, F.; Borges, F.; Silva, R.. "3-hydroxypyridin-4-one based derivatives as promising neuroprotective agents for the treatment of Parkinson¿s disease". Paper presented in Revista Científica Internacional RevSALUS, Porto, 2023. Accepted Magalhães, C.; Veloso, C.; Karkucinska-Wieckowska, A.; Amorim, R.; Simões, I.; Benfeito, S.; Borges, F.; et al. "The mitochondriotropic antioxidant antioxcin4 prevents nafld/nash-induced cardiac alterations". Paper presented in 57th ESCI 2023 Annual Scientific Meeting of the European Society for Clinical Investigation, Praga, 2023. Accepted Benfeito, S.; Fernandes, C.; Chavarria, D.; Cagide, F.; Teixeira, J.; Oliveira, P.J.; Borges, F.; Uriarte, E.. "Synthesis and in vitro evaluation of versatile cell-penetrating mitochondriotropic antioxidants". Paper presented in XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, 2022. Published • 978-84-09-45895-0 Lima, C.; Borges, F.; Benfeito, S.. "Development of new multitarget-directed ligands with potential application in Alzheimer’s disease". Paper presented in XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, 2022. Published • 978-84-09-45895-0 Mariana Castelôa; Pedro Soares; Benfeito, S.; Carla Lima; Fernanda Borges; Daniel Chavarria. "Tailoring VAS2870 scaffold to develop new covalent NOX2 inhibitors". Paper presented in XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, 2022. Published • 978-84-09-45895-0 J. Teixeira; R. Amorim; I. Simões; F. Cagide; P. Soares; Benfeito, S.; M. Wieckowski; F. Borges; P.J. Oliveira. "Mitochondriotropic Antioxidants Based on Hydroxycinnamic Acids Activates Nrf2 Mediated Cell Signalling responses to Oxidative Stress: Implications in Non-Alcoholic Fatty Liver Disease (NAFLD)". Paper presented in 56th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, 2022. Published • 10.1111/eci.13796 P. Soares; A. Alefim; D. Mena; C. Fernandes; S. Benfeito; P.J. Oliveira; F. Borges. "Targeting neuroinflammation and modulating iron dysregulation with innovative multitarget therapeutics for amyotrophic lateral sclerosis". Paper presented in 56th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, 2022. Published • 10.1111/eci.13796 R. Amorim; R. Simões; J. Teixeira; Benfeito, S.; S. Pereira; Y. Potes; P.J. Oliveira; F. Borges. "Mitochondriotropic antioxidant AntiOxCin4 improves mitochondrial function and prevents non-alcoholic fatty liver (NAFL)-associated autophagic blockage in Western diet (WD)-fed mice". Paper presented in 56th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, 2022. Published • 10.1111/eci.13796 D. Mena; P. Soares; S. Benfeito; F. Cagide; P. Valente; E. Ferreiro; P.J. Oliveira; F. Borges. "The mitochondria-targeted antioxidant AntiOxCIN4 is beneficial against oxidative/nitrosative stress in the amyotrophic lateral sclerosis SOD1G3A Mouse". Paper presented in 56th Annual Scientific Meeting of the European Society for Clinical Investigation, Bari, 2022. Published • 10.1111/eci.13796 V. Silva; S. Benfeito; E. Gil-Martins; I. Costa; F. Remião; F. Borges; R. Silva. "In vitro neuroprotective effects of dual-acting antiparkinsonians". Paper presented in Revista Científica Internacional RevSALUS, Porto, 2022. Published • 10.51126/revsalus.v4iSup.396 Costa, I.; Benfeito, S.; Cagide, F.; Silva, V.; Borges, F.; Remião, F.; Silva, R.. "New mitochondria-targeted antioxidants as promising drug candidates for the treatment of Parkinson’s disease". Paper presented in Toxicol. Lett, Maastricht, 2022. Published • 10.1016/j.toxlet.2022.07.803 Amorim, R.; Teixeira, J.; Benfeito, S.; Cagide, F.; Borges, F.; Oliveira, P.J.. "Decrypting the Nrf2-dependent antioxidant mechanism of action behind the beneficial effcts of the mitochondriotropic cinnamic acid AntiOxCIN4". Paper presented in 55th Annual meeting of the European Society for Clinical Investigation, “The Micro Me’s – Exploring microbiota in health and disease”, online, 2021. Published • 10.1111/eci.13567 Deus, C.; Pereira, S.; Cunha-Oliveira, T.; Teixeira, J.; Simões, R.; Cagide, F.; Benfeito, S.; Borges, F.. "A novel phenolic acid-based mitochondria-targeted antioxidant improves cellular responses to oxidative stress in fibroblasts from sporadic Parkinson's disease patients". Paper presented in 55th Annual meeting of the European Society for Clinical Investigation, The Micro Me- Exploring microbiota in health and disease, Online, 2021. Published • 10.1111/eci.13567 Martins, J.; Duarte, J.; Veloso, C.; Fernande, C.; Videira, A.; Benfeito, S.; Santos, A.; et al. "Mitochondriotropic Antioxidant Based on Caffeic Acid (MC4) Protects H9c2 Cardiomyoblasts against the Cardiotoxicity of Doxorubicin". Paper presented in 55th Annual meeting of the European Society for Clinical Investigation, The Micro Me's -Exploring microbiota in health and disease, Online, 2021. Published • 10.1111/eci.13567 Deus, C.; Pereira, S.; Cunha-Oliveira, T.; Teixeira, T.; Simões, R.; Cagide, F.; Benfeito, S.; et al. "AntiOxCIN4 a new mitochondriotropic derivative based on the natural polyphenol caffeic acid reverts cellular and mitochondrial metabolic defects of fibroblasts from idiopathic Parkinson's Disease". Paper presented in 55th Annual meeting of the European Society for Clinical Investigation, The Micro Me's -Exploring microbiota in health and disease, Online, 2021. Published • 10.1111/eci.13567 Duarte, A.; Coelho, A.; Mena, D.; Silva,F.; Marques, R. ; Cagide, F.; Benfeito, S.; Soares, P.; Borges, F.. "Effect of Novel Mitochondria-Targeted Antioxidants in Human Skin Fibroblasts". Paper presented in 55th Annual meeting of the European Society for Clinical Investigation, The Micro Mes - Exploring microbiota in health and disease, Online, 2021. Published • 10.1111/eci.13567 Fernades, C.; Pinto, M.; Martins, E.; Silva, R.; Benfeito, S.; Mendes, R.; Paz, F.; Remião, F.; Borges, F.. "The nanomaterial toolkit for neurological disorders treatment.". Paper presented in Paper presented in CIQUP II Workshop Meeting, Porto, 2020. Published Deus, C; Pereira, SP; Cunha Oliveira, T; Benfeito, S; Cagide, F; Borges, F; Raimundo, N; Oliveira, PJ. "Human skin fibroblasts from sporadic Parkinson's disease patients as a surrogate to measure the efficacy of novel mitochondria-directed antioxidant therapy". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation “The Clocks of Metabolism and Disease”, Eur. J. Clin. Invest., Coimbra, 2019. Published • 10.1111/eci.13109 Veloso, C; Cagide, F; Benfeito, S; Oliveira, C; Borges, F; Oliveira, P; Teixeira, J. "Mitochondriotropic antioxidants based on dietary phenolic acids: Potential effect against chemical-induced skin senescence". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation “The Clocks of Metabolism and Disease”, Eur. J. Clin. Invest., Coimbra, 2019. Published • 10.1111/eci.13109 Pinto, M; Fernandes, C; Gil Martins, E; Silva, R; Benfeito, S; Cagide, F; Borges, F; Remiao, F. "Bioavailability improvement of a monoamine oxidase-B inhibitor using PEGylated PCL-based nanoparticles". Paper presented in 55th Congress of the European Societies of Toxicology, Toxicology- Science Providing Solutions, Helsinki, 2019. Published • 10.1016/j.toxlet.2019.09.002 Benfeito, S; Oliveira, C; Fernandes, C; Cagide, F; Teixeira, J; Amorim, R; Garrido, J; et al. "Design and synthesis of mitochondriotropic antioxidants based on dietary scaffolds endowed with neuroprotective activity and BBB permeability". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation- The Clocks of Metabolism and Disease¿, Eur. J. Clin. Invest., Coimbra, 2019. Published • 10.1111/eci.13109 Amorim, R.; Teixeira, J.; Benfeito, S.; Cagide, F.; Taveres, L.C.; Jones, J.G.; Borges, F.; Oliveira, P.J. "Unraveling the mechanism throughout mitochondriotropic cinnamic acid antioxidants increase cellular stress responses in HepG2 cells". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation - The Clocks of Metabolism and Disease”, Eur. J. Clin. Invest., Coimbra, 2019. Published • 10.1111/eci.13109 Barbosa, A.; Amorim, R.; Tavares, L.C.; Jones, J.G; Veloso, C.; Benfeito, S.; Oliveira, C.; et al. "Redox signaling and metabolism modulation of human fibroblasts by mitochondria-targeted polyphenolic constructs". Paper presented in 53rd Annual Scientific Meeting of the European Society for Clinical Investigation “The Clocks of Metabolism and Disease”, Eur. J. Clin. Invest., Coimbra, 2019. Published • 10.1111/eci.13109 Deus, CM; Pereira, SP; Cunha Oliveira, T; Benfeito, S; Cagide, F; Borges, F; Raimundo, N; Oliveira, PJ. "Targeting dietary antioxidants to mitochondria ameliorate metabolic alterations of skin fibroblasts from patients with sporadic Parkinson's Disease". Paper presented in 52nd Annual Scientific Meeting of the European Society for Clinical Investigation “Precision medicine for healthy ageing”, Eur. J. Clin. Invest., Coimbra, 2018. Published • 10.1111/eci.12926 Veloso, C; Teixeira, J; Cagide, F; Benfeito, S; Oliveira, C; Borges, F; Oliveira, P. "Mitochondriotropic antioxidants based on dietary phenolic acids as modulators of oxidative stress on skin fibroblasts". Paper presented in 52nd Annual Scientific Meeting of the European Society for Clinical Investigation “Precision medicine for healthy ageing”, Eur. J. Clin. Invest., Barcelona, 2018. Published • 10.1111/eci.12926 Teixeira, J.; Amorim, R.; Carreira, R.; Benfeito, S.; Cagide, F.; Borges, F.; Oliveira, P.J.. "Effects of multi-operational mitochondria-targeted antioxidants in human hepatic cells: promising drugs for liver disease.". Paper presented in 52nd Annual Scientific Meeting of the European Society for Clinical Investigation “Precision medicine for healthy ageing”, Eur. J. Clin. Invest., Barcelona, 2018. Published • 10.1111/eci.12926 Amorim, R.; Teixeira, J.; Benfeito, S.; Cagide, F.; Garrido, J.; Oliveira, P.J.; Borges, F.. "Mitochondriotropic cinnamic acid antioxidants increase cellular stress responses in HepG2 cells: involvement of mitochondrial ROS signaling in a possible therapy for hepatic steatosis?". Paper presented in 52nd Annual Scientific Meeting of the European Society for Clinical Investigation “Precision medicine for healthy ageing”, Eur. J. Clin. Invest., Barcelona, 2018. Published • 10.1111/eci.12926 Teixeira, J.; Basit, F.; Oliveira, P.J.; Willems, P.H.G.M.; Joosten-Wagenaars, J.; Cagide, F.; Benfeito, S.; Borges, F.; Koopman, W.J.H.. "Mitohormesis: An attempt by targeting hydroxycinnamic acid derivatives to mitochondria". Paper presented in 50th Annual Scientific Meeting of the European Society for Clinical Investigation, Eur. J. Clin. Invest.,, Paris, 2016. Published • 10.1111/eci.12613 Teixeira, J.; Benfeito, S.; Soares, P.; Gaspar, A.; Garrido, J.; Murphy, M.P.; Oliveira, P.J.; Borges, F.. "Development of novel systems to deliver natural antioxidants to mitochondria: MitoCIN'S as a case study". Paper presented in 47th Annual Scientific Meeting of the European Society for Clinical Investigation, Eur. J. Clin. Invest., Albufeira, 2013. Published • 10.1111/eci.12059 Borges, F.; Gaspar, A.; Silva, T.; Teixeira, J.; Cagide, F.; Benfeito, S.; Oliveira, C.; et al. "Striving for success in antioxidant therapy for neurodegenerative diseases: current status and future prospects". Paper presented in EFMC-ISMC 2012 - 22nd International Symposium on Medicinal Chemistry. ChemMedChem, Berlim, 2012. Published Oliveira, C; Benfeito, S; Teixeira, J; Soares, P; Garrido, J; Borges, F. "Bridging the gap between nature and antioxidant setbacks: Delivering hydroxybenzoic acids to mitochondria". Paper presented in Society for Free Radical Research International 16th Biennial Meeting. Free Rad. Biol. Med., Londres, 2012. Published • 10.1016/j.freeradbiomed.2012.08.214 Teixeira, J; Silva, T; Benfeito, S; Gaspar, A; Garrido, J; Borges, F. "Exploring natural profits: Development of novel and potent galloyl-cinnamic hybrids lipophilic antioxidants". Paper presented in Society for Free Radical Research International 16th Biennial Meeting. Free Rad. Biol. Med., Londres, 2012. Published • 10.1016/j.freeradbiomed.2012.08.213 Benfeito, S.; Oliveira, C.; Teixeira, J.; Soares, P.; Gaspar, A.; Garrido, J.; Borges, F.. "Opening a new avenue in neurodegenerative therapy: lead optimization of a mitochondria-targeted cinnamic antioxidant". Paper presented in Society for Free Radical Research International 16th Biennial Meeting. Free Rad. Biol. Med., Londres, 2012. Published • 10.1016/j.freeradbiomed.2012.08.214
Conference poster	Soares, L.; Lima, C.; Chavarria, D.; Sequeira, L.; Alves, C.; Borges, F.; Benfeito, Ester. "Development of new iron chelators targeting mitochondia with potential application in Friedreich ataxia". Paper presented in IJUP - Investigação Jovem da Universidade do Porto (17th Edition), 2024. Castelôa, M.; Lima, C.; Benfeito, S.; Soares, P.; Borges, F.; Chavarria, D.. "Fine-tuning the reactivity and drug-like profile of potential covalent NOX2 inhibitors". Paper presented in XII Meeting of the Paul Ehrlich Euro-PhD Network, Thessaloniki, Greece, 2023. Magalhães, C.; Veloso, C.; Silveira, R. ; Djedovic, I.; Mendes, V.; Karkucinska-Wieckowska, A.; Amorim, R.; et al. "The mitochondriotropic antioxidant antioxcin4 prevents nafld/nash-induced cardiac alterations". Paper presented in 57th ESCI 2023 Annual Scientific Meeting of the European Society for Clinical Investigation, Prague, Czech Republic,, 2023. Lima, C.; Borges, F.; Benfeito, S.. "Development of new multitarget-directed ligands with potential application in Alzheimer’s disease". Paper presented in MitoPorto- Mitochondrial physiology, redox biology, and genetics, Porto, Portugal, 2023. Veloso, C.; Magalhães, C.; Silveira, R. ; Djedovic, I.; Mendes, V.; Karkucinska-Wieckowska, A.; Amorim, R.; et al. "Alterations in cardiac metabolism in Western Diet-induced metabolic syndrome: exploring the effects of AntiOxCIN4, a mitochondriotropic antioxidant.". Paper presented in MitoPorto- Mitochondrial physiology, redox biology, and genetics, Porto, Portugal, 2023. Amorim, R.; Magalhães, C.; Benfeito, S.; Tavares, L.; Jones, J.; Borges, F.; Oliveira, P.J.; Teixeira, J.. "ANTICANCER PROPERTIES OF ANTIOXCIN6, A NOVEL MITOCHONDRIA-TARGETED CAFFEIC ACID DERIVATIVE". Paper presented in MitoPorto- Mitochondrial physiology, redox biology, and genetics, Porto, Portugal, 2023. Barreiro, Sandra; Benfeito, S.; Fernandes, C.; Chavarria, D.; Cagide, F.; Sequeira, L.; Teixeira, J.; et al. "Nitrogen-based cationic carriers as a game changer in the development of mitochondriotropic antioxidants". Paper presented in MitoPorto- Mitochondrial physiology, redox biology, and genetics, Porto, Portugal, 2023. Alves, C.; Benfeito, S.; Cagide, F.; Borges, F.. "Development of new antimicrobial compounds to fight infectious diseases". Paper presented in IJUP'23 -XVI Encontro de Jovens Investigadores da Universidade do Porto , Porto, Portugal, 2023. Costa, I.; Benfeito, S.; Silva, V.; Cagide, F.; Borges, F.; Remião, F.; Silva, R.. "New mitochondria-targeted hydroxycinnamic and hydroxybenzoic acids derivatives as innovative agents for the treatment of Parkinson’s disease". Paper presented in IJUP'23 -XVI Encontro de Jovens Investigadores da Universidade do Porto , Porto, Portugal, 2023. Albuquerque, B.; Benfeito, S.; Chavarria, D.; Serrao, M.P.; Borges, F.; Soares-da-Silva, Patricio. "Pharmacodynamic evaluation of novel Catechol-O-methyltransferase inhibitors". Paper presented in IJUP'23 - XVI Encontro de Jovens Investigadores da Universidade do Porto, Porto, Portugal, 2023. Costa, I.; Benfeito, S.; Silva, V.; Cagide, F.; Borges, F.; Remiao, F.; Silva, R.. "Mitochondria-targeted antioxidants as powerful therapeutic strategies for Parkinson’s disease: in vitro evaluation of neuroprotective effects". Paper presented in MitoPorto- Mitochondrial physiology, redox biology, and genetics, Porto, Portugal, 2023. Costa, I.; Benfeito, S.; Silva, V.; Cagide, F.; Borges, F.; Remião, F.; Silva, R.. "In vitro evaluation of the neuroprotective effects of new mitochondria-targeted antioxidants with potential for Parkinson¿s disease treatment". Paper presented in II TOXRUN International Congress 2023, Porto, Portugal, 2023. Silva, V.; Benfeito, S.; Lima, C.; Chavarria, D.; Gonçalves, T.; Costa, I.; Remiao, F.; Borges, F.; Silva, R.. "3-hydroxypyridin-4-one based derivatives as promising neuroprotective agents for the treatment of Parkinson’s disease". Paper presented in II TOXRUN International Congress 2023, Porto, Portugal, 2023. Magalhães, C.; Veloso, C.; Silveira, R. ; Djedovic, I.; Mendes, V.; Karkucinska-Wieckowska, A.; Amorim, R.; et al. "Antioxidante mitocondriotrópico AntiOxCIN4 previne as alterações cardíacas no contexto da doença do fígado gordo não-alcóolico". Paper presented in 19º Congresso Português de Diabetes, Vilamoura, Portugal, 2023. Castelôa, M.; Soares, P.; Benfeito, Ester; Lima, C.; Borges, F.; Chavarria, D.. "Tailoring VAS2870 scaffold to develop new covalent NOX2 inhibitors". Paper presented in XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, Spain, 2022. Benfeito, S.; Fernandes, C.; Chavarria, D.; Barreiro, S.; Cagide, F.; Silva, C.; Teixeira, J.; et al. "Synthesis and in vitro evaluation of versatile cell-penetrating mitochondriotropic antioxidants". Paper presented in XXVI Encontro Galego-Portugués de Química, Santiago de Compostela, Spain, 2022. Benfeito, S.; Lima, C.; Borges, F.. "Development of new multitarget-directed ligands with potential application in Alzheimer’s disease". Paper presented in 1º Encontro de Ciências, Porto, Portugal, 2022. Inês Costa; Vera Silva; Sofia Benfeito; Fernando Cagide; Fernanda Borges; Fernando Remião; Renata Silva. "New mitochondria-targeted antioxidants as promising drug candidates for the treatment of Parkinson's disease". Paper presented in XVIth International Congress of Toxicology (IUTOX), Maastricht, the Netherlands, 2022. Vera Silva; Sofia Benfeito; Inês Costa; Fernando Remião; Fernanda Borges. "Evaluation of cytotoxic and Neuroprotective profile of potential dual-acting ligands for the treatment of Parkinson’s disease". Paper presented in MedChem 2022 (XI Paul Ehrlich Euro-PhD Network meeting), Barcelona, Spain, 2022. Cátia Silva; Pedro Soares; Fernando Cagide; Sofia Benfeito; Fernando Remião; Sónia Rocha; P.J. Oliveira; Fernanda Borges. "Targeting Antioxidants to Mitochondria: a new therapeutic track for Amyotrophic Lateral Sclerosis". Paper presented in MedChem 2022 (XI Paul Ehrlich Euro-PhD Network meeting), Barcelona, Spain, 2022. Daniel Chavarria; Anabela Borges; Sofia Benfeito; Carlos Fernandes; Catarina Oliveira; Marta Ribeiro; Manuel Simões; Fernanda Borges; Fernando Cagide. "Quaternary phosphonium conjugates: a new class of antimicrobial agents?". Paper presented in MedChem 2022 (XI Paul Ehrlich Euro-PhD Network meeting), Barcelona, Spain, 2022. Daniel Chavarria; Sofia Benfeito; Jorge Garrido; Paula Serrão; Soares-da-Silva, Patricio; Fernado Remião; P.J. Oliveira; Fernanda Borges. "Tackling dopamine depletion and oxidative stress with innovative caffeic acid derivatives”". Paper presented in X Meeting of the Paul Ehrlich Euro-PhD Network, Barcelona, Spain, 2022. Francesca Procopio; Raffaella Catalano; Daniel Chavarria; Sofia Benfeito; Stefano Alcaro; Fernanda Borges; Francesco Ortuso. "Non-Chiral Components of Bergamot Essential Oil: Identification of a Novel, Selective Human Monoamine Oxidase B Inhibitor". Paper presented in MedChem 2022 (XI Paul Ehrlich Euro-PhD Network meeting), Barcelona, Spain, 2022. R. Amorim; I. Simões; J. Teixeira; P. Soares; S. Benfeito; Y. Potes; S. Pereira; Oliveira, P.J.; F. Borges. "Mitochondriotropic antioxidant AntiOxCin4 improves mitochondrial function and prevents non-alcoholic fatty liver (NAFL)-associated autophagic blockage in Western diet (WD)-fed mice". Paper presented in 56th Annual Scientific Meeting - European Society for Clinical Investigation (ESCI), Bari, Italy, 2022. D. Mena; P. Soares; F. Cagide; S. Benfeito; L. Grilo; P. Valente; Borges, F.; P.J.Oliveira. "The mitochondria-targeted antioxidant AntiOxCIN4 is beneficial against oxidative/nitrosative stress in the amyotrophic lateral sclerosis SOD1G3A Mouse". Paper presented in 56th Annual Scientific Meeting - European Society for Clinical Investigation (ESCI), Bari, Italy, 2022. Ines Costa; Vera Silva; Benfeito, Sofia; Fernando Remião; Fernanda Borges; Renata Silva. "New mitochondria-targeted antioxidants as potential neuroprotective agentes". Paper presented in Encontro de Jovens Investigadores da Universidade do Porto (IJUP), Porto, Portugal, 2022. Vera Silva; Benfeito, Sofia; Ines Costa; Eva Gil-Martins; Fernando Remião; Fernanda Borges; Renata Silva. "In vitro neuroprotective effects of dual-acting antiparkinsonians". Paper presented in TOXRUN - Unidade de Investigação em Toxicologia do Instituto Universitário de Ciências da Saúde - CESPU, Porto, Portugal, 2022. Vera Silva; Sofia Benfeito; Eva Gil-Martins; Inês Costa; Fernando Remião; Fernanda Borges; Renata Silva. "In vitro neuroprotective effects of dual-acting antiparkinsonians". Paper presented in RevSALUS- Revista Científica Internacional da refe académica das Ciências da Saúde da Lusofonia, Porto, Portugal, 2022. Mena, D.; Saores, P. ; Benfeito, S.; Cagide, F.; Grilo, L.; Valente, P.; Pinheiro, P.; et al. "Beneficial effects of the mitochondria-targeted antioxidant AntiOxCIN4 against oxidative/nitrosative stress in the Amyotrophic Lateral Sclerosis SOD1G93A mouse". Paper presented in BEB Day 2022-The Overview Effect, Coimbra, Portugal, 2022. Mena, D.; Soares, P.; Benfeito, S.; Grilo, L.; Silva, D.; Valente, P.; Pinheiro, P.; et al. "Protective effects of the mitochondria-targeted antioxidant Antioxcin4 against oxidative stress in the amyotrophic lateral sclerosis sod1g93a mouse". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience (Virtual Meeting), 2021. Mena, D.; Soares, P.; Cagide, F.; Benfeito, S.; Grilo, L.; Valente, P.; Pinheiro, P.; et al. "The Mitochondria-Targeted Antioxidant AntiOxCIN4 Protects Against Oxidative/Nitrosative Stress in the Amyotrophic Lateral Sclerosis SOD1GG3A Mouse". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, Coimbra, Portugal, 2021. Amorim, R.; Benfeito, S.; Borges, F.; Oliveira, P.J.. "Mitochondria-targeted antioxidant based on caffeic acid AntiOxCIN4 prevented hepatic lipid accumulation by avoided Western Diet-induced autophagic blockage". Paper presented in EASL NAFLD Summit 2021 (Virtual Meeting), 2021. Catalao, R.; Maruca, A.; Rocca, S.; Borges, F.; Benfeito, S.; Chavarria, D.; Alcaro, S.; Ortuso, F.. "Phytocompounds and their metabolites profiling, as promising multi-target agents for the treatment of Alzheimer's disease". Paper presented in Virtual Meeting of the Paul Ehrlich Euro-PhD Network, 2021. Matins, J.; Duarte, J.; Veloso, C.; Fernandes, C.; Benfeito, S.; Santos, A.; Borges, F.; Oliveira, P.J.. "Mitochondriotropic antioxidants based on caffeic acid (MC4) protects H9c2 cardiomyoblasts against the cardiotoxicity of doxorubicin". Paper presented in Virtual Meeting of 55th Annual meeting of the European Society for Clinical Investigation, The Micro Me's - Exploring microbiota in health and disease, 2021. Deus, C.; Pereira, S.; Cunha-Oliveira, T.; Teixeira, J.; Cagide, F.; Benfeito, S.; Borges, F.; Oliveira, P.J.. "A novel phenolic acid-based mitochondria-targeted antioxidant improves cellular responses to oxidative stress in fibroblasts from sporadic Parkinson’s disease patients". Paper presented in Virtual Meeting of 55th Annual meeting of the European Society for Clinical Investigation, The Micro Me's - Exploring microbiota in health and disease, 2021. Deus, C.; Pereira, S.; Cunha-Oliveira, T.; Teixeira, J.; Simões, I.; Cagide, F.; Benfeito, S.; Borges, F.; Oliveira, P.J.. "AntiOxCIN4 a new mitochondriotropic derivative based on the natural polyphenol caffeic acid reverts cellular and mitochondrial metabolic defects of fibroblasts from idiopathic Parkinson’s disease". Paper presented in 55th Annual meeting of The European Society for Clinical Investigation, “The Micro Me’s – Exploring microbiota in health and disease (virtual meeting), 2021. Duarte, A.; Coelho, A.; Mena, D.; Silva, F.; Marques, R. ; Cagide, F.; Benfeito, S.; et al. "Effect of novel mitochondria-targeted antioxidants in human skin fibroblasts". Paper presented in 55th Annual meeting of the European Society for Clinical Investigation, “The Micro Me’s – Exploring microbiota in health and disease, Virtual meeting, 2021. Castelôa, M.; Moreira-Pinto, B.; Benfeito, S; Borges, F.; Fonseca, B.; Rebelo, I.. "Evaluation of the effects of a TPP-based mitocan and two derivatives in ovarian and endometrial cancer cell lines". Paper presented in IJUP 2021 – 14th Meeting of Young Researchers of University of Porto (virtual meeting), 2021. Castelôa, M.; Moreira-Pinto, B.; Benfeito, S.; Borges, F.; Fonseca, B.; Rebelo, I.. "In vitro study of the effects of a TPP-based mitocan and two derivatives in type I and type II endometrial cancer cell lines". Paper presented in Warm-Up Olimpíadas Universitárias da Bioquímica- edição especial Covid-19. Concurso online de posters, 2021. Soares, P.; Benfeito, S.; Silva, C.; Silva, F.; Batie, M.; Oliveira, C.; Cagide, F.; et al. "Mitochondriotropic antioxidants as novel therapeutics for Amyotrophic lateral sclerosis: development of multitarget agents to prevent stress induced motor neuron death (BEST POSTER)". Paper presented in MuTaLig COST ACTION CA1513, 4th WG meeting, Izmir, Turkey, 2020. Benfeito, S.; Fernandes, C.; Vilar, S.; Remião, F.; Uriarte, E.; Borges, F.. "Exploring the multi-target performance of mitochondriotropic antioxidants against the pivotal Alzheimer’s disease pathophysiological hallmarks". Paper presented in MuTaLig COST ACTION CA1513, 4th WG meeting. Izmir, Turkey., 2020. Pinto, M.; Fernandes, F.; Martins, E.; Silva, R.; Benfeito, S.; Cagide, F.; Borges, F.; Remião, F.. "Bioavailability improvement of a monoamine oxidase-B inhibitor using PEGylated PCL-based nanoparticles". Paper presented in 55th Congress of the European Societies of Toxicology, Toxicology- Science Providing Solutions, Helsinki, Finlandia., 2019. Cagide, F.; Benfeito, S.; Oliveira, C.; Fernandes, C.; Gaspar, A.; Borges, F.. "Development of new antibiotics based on natural scaffolds". Paper presented in IX Meeting of the Paul Ehrlich Euro-PhD Network & MuTaLig COST Action meeting, Catanzaro, Italy, 2019. Barbosa, A.; Amorim, R.; Benfeito, S.; Taveres, L.C.; Jones, J.G.; Veloso, C.; Oliveira, C.; Borges, F.; Olivera, P.J.. "Redox signaling and metabolism modulation of human fibriblasts by mitochondria-targeted polyphenolic constructs". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation - The Clocks of Metabolism and Disease”, Coimbra, Portugal, 2019. Benfeito, S.; Amorim, R.; Teixeira, J.; Cagide, F.; Tavares, L.C.; Jones, J.G.; Oliveira, P.J.; Borges, F.. "Unraveling the mechanism throughout mitochondriotropic cinnamic acid antioxidants increase cellular stress response in HepG2 cells". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation - The Clocks of Metabolism and Disease”, Coimbra, Portugal., 2019. Deus, C.M.; Pereira, S.; Cunha-Oliveira, T.; Benfeito, S.; Cagide, F.; Borges, F.; Raimundo, N.; Oliveira, P.J.. "Human skin fibroblasts from sporadic Parkinson’s disease patients as a surrogate to measure the efficacy of a novel mitochondria-directed antioxidant therapy". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation “The Clocks of Metabolism and Disease”, Coimbra, Portugal, 2019. Benfeito, S.; Oliveira, C.; Fernandes, C.; Cagide, F.; Teixeira, J.; Amorim, R.; Garrido, J.; et al. "Design and synthesis of mitochondriotropic antioxidants based on dietary scaffold endowed with neuroprotective activity and BBB permeability". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation - The Clocks of Metabolism and Disease, Coimbra, Portugal., 2019. Veloso, C.; Benfeito, S.; Cagide, F.; Oliveira, C.; Borges, F.; Oliveira, P.J.; Teixeira, J.. "Mitochondriotropic antioxidants based on dietary phenolic acids: Potential effect against chemical-induced skin senescence". Paper presented in 53rd Annual Meeting of the European Society for Clinical Investigation - The Clocks of Metabolism and Disease”, Coimbra, Portugal,, 2019. Soares, P.; Benfeito, S.; Oliveira, C.; Cagide, F.; Fernandes, C.; Teixeira, J.; Amorim, R.; Oliveira, P.J; Borges, F.. "From nature inspiration to multitarget small molecules: upgrading the activity of dietary cinnamic and benzoic acids for the treatment of neurodegenerative disorders (BEST POSTER)". Paper presented in MuTaLig COST ACTION CA1513, 3th WG meeting, Paris, France., 2019. Barbosa, A.; Amorim, R.; Veloso, C.; Benfeito, S.; Oliveira, C.; Borges, F.; Oliveira, P.J.; Teixeira, J.. "Targeting Phenolic Dietary Antioxidants to Mitochondria to Modulate Redox Signaling and Metabolism". Paper presented in Meeting Sociedade Portuguesa de Farmacologia (SPF), Universidade do Porto, Porto, Portugal, 2019. Veloso, C.; Cagide, F.; Benfeito, S.; Borges, F.; Oliveira, P.J.; Teixeira, J.. "Mitochondriotropic antioxidants based on dietary hydroxycinnamic acids as an attempt to reduce skin aging". Paper presented in Meeting Sociedade Portuguesa de Farmacologia (SPF), Universidade do Porto, Porto, Portugal, 2019. Amorim, R.; Teixeira, J.; Veloso, C.; Benfeito, S.; Cagide, F.; Borges, F.; Oliveira, P.J.. "Mitochondria-targeted Antioxidants in Human Hepatic Cells: A Conceivable Therapy for Non-Alcoholic Fatty Liver Disease". Paper presented in Targeting Mitochondria, Berlin, Germany., 2018. Cagide, F.; Benfeito, S.; Oliveira, C.; Fernandes, C.; Teixeira, J.; Amorim, R.; Garrido, J.; et al. "Fine-tuning the neuroprotective and blood-brain barrier permeability profile of dietary based mitochondria-targeted antioxidants". Paper presented in MuTaLig COST ACTION CA1513, WG meeting, Valletta, Malta, 2018. Fernandes, C.; Benfeito, S.; Amorim, R.; Teixeira, J.; Oliveira, P.J.; Remião, F.; Borges, F.. "Modulating the cytotoxicity of a mitochondriotropic antioxidant by a flexible PEGylation strategy". Paper presented in MuTaLig COST ACTION CA1513, WG meeting, Valletta, Malta, 2018. Amorim, R.; Teixeira, J.; Benfeito, S.; Cagide, F.; Borges, F.; Oliveira, P.J.. "Effects of mitochondria-targeted antioxidants in human hepatic cells: a possible therapy for hepatic steatosis". Paper presented in MuTaLig COST ACTION CA1513, WG meeting, Valletta, Malta, 2018. Teixeira, J.; Amorim, R.; Benfeito, S.; Cagide, F.; Oliveira, P.J.; Borges, F.. "Mitochondriotropic cinnamic acid antioxidants improves steatosis in a Non-Alcoholic Fatty Liver Disease (NAFLD) cell model". Paper presented in MitoPorto: Mitochondrial Evolution, Metabolism and Disease International Symposium, Porto, Portugal, 2018. Amorim, R.; Teixeira, J.; Baldeiras, I.; Benfeito, S.; Cagide, F.; Garrido, J.; Oliveira, P.J.; Borges, F.. "Mitochondriotropic cinnamic acid antioxdiants increase celular stress responses in HepG2 cells: Involvement of (mt)ROS signaling?". Paper presented in MitoPorto: Mitochondrial Evolution, Metabolism and Disease International Symposium, Porto, Portugal,, 2018. Deus, C.M.; Pereira, S.P.; Cunha-Oliveira, T.; Benfeito, S.; Cagide, F.; Borges, F.; Raimundo, N.; Oliveira, P.J.. "Targeting mitochondria with mitochondria-targeted cinnamic antioxdidants: a new avenue for sporadic Parkinson’s Disease therapy". Paper presented in MitoPorto: Mitochondrial Evolution, Metabolism and Disease International Symposium, Porto, Portugal,, 2018. Veloso, C.; Cagide, F.; Benfeito, S.; Oliveira, C.; Borges, F.; Oliveira, P.J; Teixeira, J.. "Skin aging and mitochondriotropic antioxidants based on dietary hydroxycinnamic acids". Paper presented in MitoPorto: Mitochondrial Evolution, Metabolism and Disease International Symposium, Porto, Portugal, 2018. Carreira, R.; Amorim, R.; Benfeito, S.; Cagide, F.; Borges, F.; Oliveira, P.J.; Teixeira, J.. "Effect of multi-functional mitochondria-targeted antioxidants in human skin fibroblasts". Paper presented in MitoPorto: Mitochondrial Evolution, Metabolism and Disease International Symposium, Porto, Portugal, 2018. Benfeito, S.; Cagide, F.; Teixeira, J.; Amorim, R.; Remião, F.; Uriarte, E.; Oliveira, P.J.; Borges, F.. "Restoring acetylcholine levels and shielding mitochondria as a multi-target strategy for neurodegenerative diseases". Paper presented in VIII Meeting of the Paul Ehrlich MedChem EuroPhD Network, Porto, Portugal, 2018. Amorim, R.; Teixeira, J.; Benfeito, S.; Cagide, F.; Oliveira, P.J.; Borges, F.. "Mitochondriotropic cinnamic acid antioxidants increase cellular stress response in HepG2 cells: involvement of mitochondrial ROS signaling in a possible therapy for hepatic steatosis". Paper presented in 52nd Annual Meeting of the European Society for Clinical Investigation “Precision Medicine for Healthy Ageing”, Barcelona, Spain, 2018. Veloso, C.; Teixeira, J.; Cagide, F.; Benfeito, S.; Oliveira, C.; Borges, F.; Oliveira, P.J.. "Mitochondriotropic antioxidants based on dietary phenolic acids as modulators of oxidative stress on skin fibroblasts". Paper presented in 52nd Annual Meeting of the European Society for Clinical Investigation “Precision Medicine for Healthy Ageing”, Barcelona, Spain, 2018. Teixeira, J.; Amorim, R.; Carreira, R.; Cagide, F.; Benfeito, S.; Borges, F.; Oliveira, P.J.. "Effects of multi-operational mitochondria-targeted antioxidants in human hepatic cells: promising drugs for liver disease". Paper presented in 52nd Annual Meeting of the European Society for Clinical Investigation “Precision Medicine for Healthy Ageing”, Barcelona, Spain, 2018. Deus, C.; Pereira, S.; Cunha-Oliveira, T.; Benfeito, S.; Cagide, F.; Borges, F.; Raimundo, N.; Oliveira, P. J.. "Targeting dietary antioxidants to mitochondria ameliorate metabolic alterations of skin fibroblasts from patients with sporadic Parkinson’s Disease". Paper presented in 52nd Annual Meeting of the European Society for Clinical Investigation “Precision Medicine for Healthy Ageing, Barcelona, Spain, 2018. Cagide, F.; Benfeito, S.; Teixeira, J.; Silva, R.; Remião, F.; Garrido, J.; Oliveira, P.J.; Uriarte, E.; Borges, F.. "Cationic derivatives of natural products as inhibitors of enzymes involved in Alzheimer's disease". Paper presented in MuTaLig COST ACTION CA1513, WG meeting, Tenerife, Spain, 2018. Teixeira, J.; Amorim, R.; Carreira, R.; Benfeito, S.; Cagide, F.; Oliveira, P.J.; Borges, F.. "Mitochondria-targeted cinnamic antioxidants increase celular stress response through modulation of mitochondria function/activity". Paper presented in MuTaLig COST action, Universidad de la Laguna, Tenerife, Spain, 2018. Benfeito, S.; Cagide, F.; Teixeira, J.; Amorim, R.; Remião, F.; Uriarte, E.; Oliveira, P.J.; Borges, F.. "Targeted delivery of mitocondriotropics derivatives: a new therapeutic approach for oxidative stress related diseases". Paper presented in EpiChemBio (CM1406) and MuTaLig COST (CA15135) Actions Joint Meeting, Porto, Portugal, 2017. Cagide, F.; Benfeito, S.; Fernandes, C.; Remião, F.; Uriarte, E.; Borges, F.. "Cationic derivatives based on cinnamic acid as dual-target ligands for the treatment of neurodegenerative diseases". Paper presented in EpiChemBio (CM1406) and MuTaLig COST (CA15135) Actions Joint Meeting, Porto, Portugal, 2017. Deus, C.M.; Pereira, S.P.; Cunha-Oliveira, T.; Benfeito, S.; Cagide, F.; Borges, F.; Raimundo, N.; Oliveira, P.J.. "Mitochondria-directed antioxidants increased metabolic viability of human skin fibroblasts from Parkinson´s Disease patients". Paper presented in EpiChemBio (CM1406) and MuTaLig COST (CA15135) Actions Joint Meeting, Porto, Portugal, 2017. Cagide, F.; Benfeito, S.; Fernandes, C.; Remião, F.; Uriarte, E.; Borges, F.. "New bifunctional agents for the treatment of the oxidative stress associated with aging related diseases". Paper presented in VII Meeting of the Paul Ehrlich MedChem EuroPhD Network, Vienna, Austria, 2017. Amorim, R.; Teixeira, J.; Benfeito, S.; Cagide, F.; Garrido, J.; Oliveira, P.J.; Borges, F.. "Effects of different targeting cations on the toxicity profile of mitochondriotropic-hydroxycinnamic antioxidants". Paper presented in MitoPorto: Advances in Mitochondrial Research International Symposium, Porto, Portugal, 2017. Benfeito, S.; Remião, F.; Uriarte, E.; Borges, F.. "Development of bifunctional agents for ameliorating the oxidative stress associated with aging related diseases". Paper presented in Mutalig COST Action, 1st WG meeting “Poly-pharmacology expanding Paul Elrlich’s magic bullet concept”, Budapest, Hungry, 2016. Benfeito, S.; Remião, F.; Uriarte, E.; Borges, F.. "Development of bifunctional agents for ameliorating the oxidative stress associated with aging related diseases (BEST POSTER)". Paper presented in 36th Edition of the European School of Medicinal Chemistry (ESMEC), Urbino, Italy, 2016. Benfeito, S.; Andrade, M.; Soares, P.; Simões, M.; Borges, F.. "Fine-tuning of the antimicrobial activity of caffeic acid". Paper presented in XXII Young Research Fellow Meeting, Paris, France, 2015. Benfeito, S.; Silva, T.; Garrido, J.; Remiao, F.; Borges, F.. "Development of novel cinnamoyl-piperazine derivatives endowed with antioxidant-anticholinesterase activity". Paper presented in Paul Ehrlich MedChem - Euro PhD Network, Prague, Czech Republic, 2014. Teixeira, J.; Cagide, F.; Benfeito, S.; Soares, P.; Borges, F.; Oliveira, P.J.; Murphy, M.P.; Andrade, P.B.. "MITOCIN’S - the Highway to Target Bioactive Cinnamic Molecules to Mitochondria". Paper presented in 8th World Congress on Polyphenols Applications: ISANH Polyphenols, Lisboa, Portugal, 2014. Cerqueira, A.; Benfeito, S.; Garrido, J.; Borges, F.; Garrido, E.M.. "Cyclodextrin-encapsulated herbicides: A promising technology". Paper presented in IJUP14 7th Meeting of the young researchers of U. Porto, Porto, Portugal, 2014. Benfeito, S.; Garrido, J.; Sottomayor, M.J.; Borges, F.; Garrido, E.M.. "Avaliação da interacção entre os herbicidas fenoxiacéticos e o ADN". Paper presented in XIX Encontro Luso-Galego de Química, Spain, Vigo, 2013. Garrido, E.M.; Benfeito, S.; Fernandes, C.; Garrido, J.; Blorges, F.. "Cyclodextrins: an eco-friendly contribution to management of herbicide MCPA". Paper presented in 10th Green Chemistry Conference, Spain, Barcelona,, 2013. Oliveira, C.; Benfeito, S.; Teixeira, J.; Amorim, R.; Gaspar, A.; Garrido, J.; Uriarte, E; Oliveira, P.J.; Borges, F.. "Remaking of Dietary Antioxidants: Targeting MitoBEN’s to Mitochondria as a New Therapeutic Strategy". Paper presented in 10º Encontro Nacional de Química Orgânica- 10ENQO, Lisboa, Portugal, 2013. Benfeito, S.; Oliveira, C.; Teixeira, J.; Soares, P.; Gaspar, A.; Garrido, J.; Uriarte, E.; Oliveira, P.J.; Borges, F.. "Targeted Delivery of MitoCIN's: a new Therapeutic Approach for Oxidative Stress Related Diseases". Paper presented in 10º Encontro Nacional de Química Orgânica- 10ENQO, Portugal, Lisbon, 2013. Benfeito, S.; Garrido, J.; Garrido, E. M.; Sottomayor, M.J.; Borges, F.. "Study of the interaction of Phenoxyacetic acid herbicides with DNA using UV-Vis Spectroscopy". Paper presented in 11º Encontro Nacional de Química Física- 11ENQF, Porto, Portugal, 2013. Teixeira, J.; Silva, T.; Benfeito, S.; Gaspar, A.; Garrido, E. M.; Garrido, J.; Borges, F.. "Exploring natural profits: development of novel and potent galloyl-cinnamic hybrids lipophilic antioxidants". Paper presented in 16th biennial meeting for the Society for Free Radical Research International, London, UK, 2012. Oliveira, C.; Benfeito, S.; Teixeira, J.; Soares, P.; Gaspar, A.; Garrido, J.; Borges, F.. "Bridging the gap between Nature and antioxidant setbacks: delivering hydroxybenzoic acids to mitochondria". Paper presented in 16th biennial meeting for the Society for Free Radical Research International, London, UK, 2012. Benfeito, S.; Oliveira, C.; Teixeira, J.; Soares, P.; Gaspar, A.; Garrido, J.; Borges, F.. "Opening a new avenue in neurodegenerative therapy: lead optimization of a mitochondria-targeted cinnamic antioxidant". Paper presented in 16th biennial meeting for the Society for Free Radical Research International, London, UK, 2012. Borges, F.; Gaspar, A.; Silva, T.; Teixeira, J.; Cagide, F.; Benfeito, S.; Oliveira, C.; et al. "Striving for success in antioxidant therapy for neurodegenerative diseases: current status and future prospects". Paper presented in 22nd International Symposium on Medicinal Chemistry, Berlin, Germany, 2012. Oliveira, C.; Benfeito, S.; Teixeira, J.; Soares, P.; Gaspar, A.; Garrido, J.; Borges, F.. "Opening a new avenue in neurodegenerative therapy: development of a mitochondria-targeted antioxidants based on benzoic scaffold". Paper presented in IJUP12 5th Meeting of the young researchers of U. Porto, Porto, Portugal, 2012. Benfeito, S.; Oliveira, C.; Teixeira, J.; Soares, P.; Gaspar, A.; Garrido, J.; Borges, F.. "Opening a new avenue in neurodegenerative therapy: lead optimization of a mitochondria-targeted cinnamic antioxidant". Paper presented in IJUP12 5th Meeting of the young researchers of U. Porto, abstract book, Porto, Portugal, 2012. Teixeira, J.; Soares, P.; Benfeito, S.; Oliveira, C.; Gaspar, A.; Garrido, J.; Murphy, M.P.; Borges, F.. "Mitochondria-targeted cinnamic antioxidants: Novel Promising Drugs for treatment of Alzheimer disease". Paper presented in 6th Drug discovery for neurodegeneration conference: an intensive course on translating research into drugs, New York, USA, 2012. Benfeito, S.; Oliveira, C.; Teixeira, J.; Soares, P.; Gaspar, A.; Garrido, J.; Borges, F.. "Targeting phenolic antioxidants to mitochondria: synthesis and characterization of novel triphenylphosphonium- conjugated lipophilic cinnamic derivatives". Paper presented in 2nd Iberic Meeting on Medicinal Chemistry in Faculty of Sciences of the University of Porto, Porto, Portugal, 2011. Teixeira, J.; Benfeito, S.; Soares, P.; Borges, F.; Gaspar, A.; Garrido, J.. "Lipophilic cinnamic cations: new mitochondria-targeted antioxidants for neurodegenerative disease therapy". Paper presented in IJUP11 4th Meeting of the young researchers of U. Porto, Porto, Portugal, 2011. Benfeito, S.; Couto, M.. "Anticancer agents derived from natural products”, first workshop in Medicinal Chemistry: Drug Discovery and Development: Understanding the R&D Process,". Paper presented in Faculty of Sciences of the University of Porto, Porto, Portugal, 2010.
Journal article	Amorim, R.; Magalhães, C.; Benfeito, S.; Cagide, F.; Tavares, L.; Santos, K.; Borges, F.; et al. "Mitochondria dysfunction induced by decyl-TPP mitochondriotropic antioxidant based on caffeic acid AntiOxCIN6 sensitizes cisplatin lung anticancer therapy due to a remodeling of energy metabolism". Biochem Pharmacol. (2024): https://pubmed.ncbi.nlm.nih.gov/38036191/. Published • 10.1016/j.bcp.2023.115953 Martins, D.; Gil-Martins, E.; Cagide, F.; Soares, P.; Benfeito, S.; Fernandes, C.; Silva, R.; Borges, F.. "Unravelling the in vitro toxicity profile of psychedelic 2C phenethylamines and their N-benzylphenethylamine (NBOMe) analogues". Archives Toxicology (2023): https://www.mdpi.com/1424-8247/16/8/1158. Published • https://doi.org/10.3390/ph16081158 Fernandes, C.; Benfeito, S.; Silva, T.; Sardão, V.; Silva, R.; Oliveira, P. J.; Borges, F.; et al. "Derisking nitrocatechols: a structure-property-toxicity study of tolcapone, entacapone and derivatives thereof". RSC Adv. (2023): Submitted Cátia Silva ; Inês Simões; Carlos Fernandes; Benfeito, S.; M. Wieckowski; Pedro Soares; Fernanda Borges. "Development of a screening cascade to evaluate the lipophilicity, solubility and interaction with physiological membranes of mitochondriotropic antioxidants in early drug discovery projects". Anal. Chem. (2023): Submitted José Teixeira; C. Carreira; Fernando Cagide; A. Barbosa; R. Amorim; P.J. Oliveira; Borges, F.; et al. "Mitochondria-targeted phenolic antioxidants AntiOxBEN2 and AntiOxCIN4 differentially impact energy metabolism in human dermal fibroblasts.". Metabolism (2023): Submitted Amorim, R.; Chavarria, D.; Teixeira, J.; Benfeito, S.; Soares, P.; Cagide, F.; Borges, F.; Oliveira, P. J.. "Decreasing the Burden of Non-Alcoholic Fatty Liver Disease: from Therapeutic Targets to Drug Discovery Opportunities". Med. Res. Rev. (2023): Accepted Costa, Inês; Barbosa, Daniel José; Silva, Vera; Benfeito, Sofia; Borges, Fernanda; Remião, Fernando; Silva, Renata. "Research Models to Study Ferroptosis’s Impact in Neurodegenerative Diseases". Pharmaceutics 15 5 (2023): 1369. http://dx.doi.org/10.3390/pharmaceutics15051369. Published • 10.3390/pharmaceutics15051369 Barbosa, J.; Pinto, M.; Fernandes, C.; Benfeito, S.; Mendes, R.; Remião, F.; Borges, F.; Braga, S.; Paz, F.. "Coordination Polymers as Multi-Drug Delivery Systems". ACS Appl. Mater. Interfaces (2023): Submitted Costa, I.; Barbosa, D.; Benfeito, S.; Silva, V.; Chavarria, D.; Borges, F.; Remião, F.; Silva, R.. Corresponding author: Benfeito, S.. "Molecular mechanisms of ferroptosis and their involvement in brain diseases". Pharmacology & Therapeutics (2023): 108373. http://dx.doi.org/10.1016/j.pharmthera.2023.108373. Published • 10.1016/j.pharmthera.2023.108373 Chavarria, D.; Borges, A.; Benfeito, S.; Sequeira, L.; Ribeiro, M.; Oliveira, C.; Borges, F.; Simões, M.; Cagide, F.. "Phytochemicals and quaternary phosphonium ionic liquids: connecting the dots to develop a new class of antimicrobial agents". J. Adv. Res. 23 (2023): https://pubmed.ncbi.nlm.nih.gov/36822390/. Published • 10.1016/j.jare.2023.02.004 Benfeito, S.; Fernandes, C.; Chavarria, D.; Barreiro, S.; Cagide, F.; Sequeira, L.; Teixeira, J.; et al. "Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier Bricks". Journal of Medicinal Chemistry 66 3 (2023): 1835-1851. http://dx.doi.org/10.1021/acs.jmedchem.2c01630. Published • 10.1021/acs.jmedchem.2c01630 Benfeito, S.; Chavarria, D.; Soares, P.; Lima, C.; Garrido, J.; Soares-da-Silva, P.; Remião, F.; Borges, F.; Oliveira, PJ.. "Boosting caffeic acid performance as antioxidant and monoamine oxidase B/catechol-O-methyltransferase inhibitor". Eur. J. Med. Chem. 243 (2022): 114740. https://www.sciencedirect.com/science/article/pii/S0223523422006420. Published • 10.1016/j.ejmech.2022.114740 Amorim, R.; Benfeito, S.; Simões, I.; Borges, F.; Oliveira, P.J.. "Mitochondria-targeted antioxidant AntiOxCIN4 improved liver steatosis in Western Diet-fed mice by preventing lipid accumulation due to upregulation of fatty acid oxidation, quality control mechanism and antioxidant defense systems". Redox Biology (2022): https://pubmed.ncbi.nlm.nih.gov/35863265/. Published • 10.1016/j.redox.2022 Joana Reis; Carlos Fernandes; Hoda Salem; Marta Maia ; Cláudia Tomé; Benfeito, S.; José Teixeira; et al. "Design and synthesis of chromone-based monoamine oxidase B inhibitors with improved drug-like properties". Eur. J. Med Chem. (2022): https://www.sciencedirect.com/science/article/pii/S0223523422004093. Published • 10.1016/j.ejmech.2022.114507 Catalano, Raffaella; Procopio, Francesca; Chavarria, Daniel; Benfeito, Sofia; Alcaro, Stefano; Borges, Fernanda; Ortuso, Francesco. "Molecular Modeling and Experimental Evaluation of Non-Chiral Components of Bergamot Essential Oil with Inhibitory Activity against Human Monoamine Oxidases". Molecules 27 8 (2022): 2467. http://dx.doi.org/10.3390/molecules27082467. Published • 10.3390/molecules27082467 Mariana Castelôa; Beatriz Moreira-Pinto; Sofia Benfeito; Fernanda Borges; Bruno M. Fonseca; Irene Rebelo. "In Vitro Effects of Mitochondria-Targeted Antioxidants in a Small-Cell Carcinoma of the Ovary of Hypercalcemic Type and in Type 1 and Type 2 Endometrial Cancer". Biomedicines 10 4 (2022): 800-800. https://doi.org/10.3390/biomedicines10040800. Published • 10.3390/biomedicines10040800 Ricardo Amorim; Ludgero C. Tavares; Rui F. Simões; Pedro Soares; Fernando Cagide; Sofia Benfeito; Inês Baldeiras; et al. "Mitochondriotropic antioxidant based on caffeic acid AntiOxCIN4 activates Nrf2-dependent antioxidant defenses and quality control mechanisms to antagonize oxidative stress-induced cell damage". Free Radical Biology and Medicine 179 (2022): 119-132. http://dx.doi.org/10.1016/j.freeradbiomed.2021.12.304. Published • 10.1016/j.freeradbiomed.2021.12.304 Carlos Fernandes; Afonso J. C. Videira; Caroline D. Veloso; Sofia Benfeito; Pedro Soares; João D. Martins; Beatriz Gonçalves; et al. "Cytotoxicity and Mitochondrial Effects of Phenolic and Quinone-Based Mitochondria-Targeted and Untargeted Antioxidants on Human Neuronal and Hepatic Cell Lines: A Comparative Analysis". Biomolecules 11 11 (2021): 1605-1605. https://doi.org/10.3390/biom11111605. Published • 10.3390/biom11111605 Benfeito, S.; Deus, C.; Pereira, S.; Cunha-Oliveira, T.; Teixeira, J.; Simões, R.; Cagide, F.; et al. "Mitochondria-targeted Caffeic Acid Derivative Reverts Cellular and Mitochondrial Defects in Human Skin Fibroblasts from Male Sporadic Parkinson’s Disease Patients". Redox Biology (2021): https://pubmed.ncbi.nlm.nih.gov/34147843/. Published • 10.1016/j.redox.2021.102037 Benfeito, Sofia; Chavarria, Daniel; Da Silva, Ophelie Da; Barreiro, Sandra; Garrido, Jorge; Cagide, Fernando; Soares, Pedro; et al. "Fine-Tuning the Biological Profile of Multitarget Mitochondriotropic Antioxidants for Neurodegenerative Diseases". Antioxidants 10 2 (2021): 329. http://dx.doi.org/10.3390/antiox10020329. Published • 10.3390/antiox10020329 Teixeira, José; Basit, Farhan; Willems, Peter H.G.M.; Wagenaars, Jori A.; van de Westerlo, Els; Amorim, Ricardo; Cagide, Fernando; et al. "Mitochondria-targeted phenolic antioxidants induce ROS-protective pathways in primary human skin fibroblasts". Free Radical Biology and Medicine 163 (2021): 314-324. http://dx.doi.org/10.1016/j.freeradbiomed.2020.12.023. Published • 10.1016/j.freeradbiomed.2020.12.023 Fernandes, Eduarda; Benfeito, Sofia; Cagide, Fernando; Gonçalves, Hugo; Bernstorff, Sigrid; Nieder, Jana B; CD Real Oliveira, M Elisabete; Borges, Fernanda; Lúcio, Marlene. "Lipid Nanosystems and Serum Protein as Biomimetic Interfaces: Predicting the Biodistribution of a Caffeic Acid-Based Antioxidant". Nanotechnology, Science and Applications Volume 14 (2021): 7-27. http://dx.doi.org/10.2147/nsa.s289355. Published • 10.2147/nsa.s289355 Benfeito, Sofia; Fernandes, Carlos; Vilar, Santiago; Remião, Fernando; Uriarte, Eugenio; Borges, Fernanda. Corresponding author: Benfeito, Sofia. "Exploring the Multi-Target Performance of Mitochondriotropic Antioxidants against the Pivotal Alzheimer’s Disease Pathophysiological Hallmarks". Molecules 25 2 (2020): 276. http://dx.doi.org/10.3390/molecules25020276. Published • 10.3390/molecules25020276 Pinto, Miguel; Fernandes, Carlos; Martins, Eva; Silva, Renata; Benfeito, Sofia; Cagide, Fernando; Mendes, Ricardo F.; et al. "Boosting Drug Discovery for Parkinson’s: Enhancement of the Delivery of a Monoamine Oxidase-B Inhibitor by Brain-Targeted PEGylated Polycaprolactone-Based Nanoparticles". Pharmaceutics 11 7 (2019): 331. http://dx.doi.org/10.3390/pharmaceutics11070331. Published • 10.3390/pharmaceutics11070331 Benfeito, S.; Oliveira, C.; Fernandes, C.; Cagide, F.; Teixeira, J.; Amorim, R.; Garrido, J.; et al. "Fine-tuning the neuroprotective and blood-brain barrier permeability profile of multi-target agents designed to prevent progressive mitochondrial dysfunction". European Journal of Medicinal Chemistry 167 (2019): 525-545. http://dx.doi.org/10.1016/j.ejmech.2019.01.055. Published • 10.1016/j.ejmech.2019.01.055 Fernandes, C.; Benfeito, S.; Amorim, R.; Teixeira, J.; Oliveira, P.J.; Remião, F.; Borges, F.. "Desrisking the Cytotoxicity of a Mitochondriotropic Antioxidant Based on Caffeic Acid by a PEGylated Strategy". Bioconjugate Chemistry 29 8 (2018): 2723-2733. http://www.scopus.com/inward/record.url?eid=2-s2.0-85049630986&partnerID=MN8TOARS. Published • 10.1021/acs.bioconjchem.8b00383 Ribeiro, J.A.; Benfeito, S.; Cagide, F.; Teixeira, J.; Oliveira, P.J.; Borges, F.; Silva, A.F.; Pereira, C.M.. "Electrochemical Behavior of a Mitochondria-Targeted Antioxidant at an Interface between Two Immiscible Electrolyte Solutions: An Alternative Approach to Study Lipophilicity". Analytical Chemistry 90 13 (2018): 7989-7996. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048133687&partnerID=MN8TOARS. Published • 10.1021/acs.analchem.8b00787 Oliveira, C.; Benfeito, S.; Fernandes, C.; Cagide, F.; Silva, T.; Borges, F.. "NO and HNO donors, nitrones, and nitroxides: Past, present, and future". Medicinal Research Reviews 38 4 (2017): 1159-1187. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048825299&partnerID=MN8TOARS. Published • 10.1002/med.21461 Teixeira, J.; Cagide, F.; Benfeito, S.; Soares, P.; Garrido, J.; Baldeiras, I.; Ribeiro, J.A.; et al. "Development of a mitochondriotropic antioxidant based on caffeic acid: Proof of concept on cellular and mitochondrial oxidative stress models". Journal of Medicinal Chemistry 60 16 (2017): 7084-7098. http://www.scopus.com/inward/record.url?eid=2-s2.0-85028330575&partnerID=MN8TOARS. Published • 10.1021/acs.jmedchem.7b00741 Benfeito, S.; Andrade, M.; Soares, P.; Magalhães e Silva, D.; Loureiro, J.; Borges, A.; Borges, F.; Simões, M.. "Fine-tuning of the hydrophobicity of caffeic acid: studies on the antimicrobial activity against Staphylococcus aureus and Escherichia coli". RSC Advances 5 66 (2015): 53915-53925. http://www.scopus.com/inward/record.url?eid=2-s2.0-84934935449&partnerID=MN8TOARS. Published • 10.1039/c5ra05840f Teixeira, J.; Soares, P.; Benfeito, S.; Murphy, Michael P.; Oliveira, P.J.; Borges, F.. "Bridging the gap between nature and antioxidant setbacks: delivering caffeic acid to mitochondria". Methods in Molecular Biology 1265 (2015): 1-10. https://pubmed.ncbi.nlm.nih.gov/25634268/. Published • 10.1007/978-1-4939-2288-8_6. Benfeito, S.; Silva, T.; Garrido, J.; Andrade, P.B.; Sottomayor, M.J.; Borges, F.; Garrido, E.M.. "Effects of chlorophenoxy herbicides and their main transformation products on dna damage and acetylcholinesterase activity". BioMed Research International 2014 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84899555466&partnerID=MN8TOARS. Published • 10.1155/2014/709036 Fernandes, C.; Oliveira, C.; Benfeito, S.; Soares, P.; Garrido, J.; Borges, F.. "Nanotechnology and antioxidant therapy: An emerging approach for neurodegenerative diseases". Current Medicinal Chemistry 21 38 (2014): 4311-4327. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929085543&partnerID=MN8TOARS. Published • 10.2174/0929867321666140915141836 Benfeito, S.; Rodrigues, T.; Garrido, J.; Borges, F.; Garrido, E.M.. "Host-Guest interaction between herbicide oxadiargyl and hydroxypropyl- ß -Cyclodextrin". The Scientific World Journal 2013 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84893859565&partnerID=MN8TOARS. Published • 10.1155/2013/825206 Teixeira, J.; Silva, T.; Benfeito, S.; Gaspar, A.; Garrido, E.M.; Garrido, J.; Borges, F.. "Exploring nature profits: Development of novel and potent lipophilic antioxidants based on galloyl-cinnamic hybrids". European Journal of Medicinal Chemistry 62 (2013): 289-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873030904&partnerID=MN8TOARS. Published • 10.1016/j.ejmech.2012.12.049 Benfeito, S.; Oliveira, C.; Soares, P.; Fernandes, C.; Silva, T.; Teixeira, J.; Borges, F.. "Antioxidant therapy: Still in search of the 'magic bullet'". Mitochondrion 13 5 (2012): 427-435. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882877558&partnerID=MN8TOARS. Published • 10.1016/j.mito.2012.12.002 Teixeira, J.; Soares, P.; Benfeito, S.; Gaspar, A.; Garrido, J.; Murphy, M.P.; Borges, F.. "Rational discovery and development of a mitochondria-targeted antioxidant based on cinnamic acid scaffold". Free Radical Research 46 5 (2012): 600-611. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859067775&partnerID=MN8TOARS. Published • 10.3109/10715762.2012.662593
Preprint	Sequeira, L.; Benfeito, S.; Fernandes, C.; Gaspar, A.; Lima, I.; Peixoto, C.; Alves, C.; et al. "Drug development for Alzheimer’s and Parkinson’s disease: where do we go now?". 2024. https://www.preprints.org/manuscript/202404.0437/v1.
Thesis / Dissertation	Faculdade de Farmácia. "Design and development of multi-target agents for neurodegenerative diseases". PhD, Universidade do Porto Faculdade de Farmácia, 2018. http://hdl.handle.net/10216/114025. Faculdade de Ciências. "Desenvolvimento de novos antioxidantes lipofílicos baseados no ácido cinâmico". Master, Universidade do Porto Faculdade de Ciências, 2012. http://hdl.handle.net/10216/101959. Benfeito, S.. "Controlo de qualidade do vinho do Porto e estudo da evolução dos teores de potássio, cálcio e cobre ao longo do processo de envelhecimento/finalização por espectroscopia de absorção atómica". Degree, Universidade do Porto Faculdade de Ciências, 2010.

Intellectual property

Patent	Fernanda Borges; Paulo Oliveira; José Teixeira; Fernando Cagide; Benfeito, S.. 2019. "HYDROXYCINNAMIC DERIVATIVES, METHODS AND USES THEREOF". United States. Allowed Borges, F.; Oliveira, P.J.; Benfeito, S.; Teixeira, J.; Cagide, F.. 2018. "HYDROXYCINNAMIC DERIVATIVES, METHODS AND USES THEREOF". Portugal. Allowed
Provisional application for patent	2024. "Novel catechol-O-methyltransferase inhibitors, methods for preparation and use thereof". Protected

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/11/22	Desenvolvimento de novos agentes antibacterianos para combater infeções hospitalares	XIX Encontro Luso-Galego de Química, Spain, Vigo (Porto, Portugal)
2023/06/07	The mitochondria-targeted antioxidant AntiOxCIN4 protects against cardiac oxidative/nitrosative stress in the amyotrophic lateral sclerosis SOD1G93A mouse	57th ESCI 2023 Annual Scientific Meeting of the European Society for Clinical Investigation Facuty of Sciences of University of Porto (Prague, Czech Republic)
2022/11/16	Development of new multitarget-directed ligands with potential application in Alzheimer's disease	Encontro Galego-Portugués de Química Faculty of Sciences of University of Porto (Santiago de Compostela, Spain)
2022/06/08	Targeting neuroinflammation and modulating iron dysregulation with innovative multitarget therapeutics for Amyotrophic Lateral Sclerosis	56th Annual Scientific meeting – Promoting Biomedical Research, Equal Health, and Environment in the post-COVID Syndemic Era Faculty of Sciences of University of Porto (Bari, Italy)
2022/06/08	Mitochondriotropic Antioxidants Based on Hydroxycinnamic Acids Activates Nrf2-Mediated Cell Signalling Responses to Oxidative Stress: Implications in Non¬Alcoholic Fatty Liver Disease (NAFLD)	56th Annual Scientific meeting – Promoting Biomedical Research, Equal Health, and Environment in the post-COVID Syndemic Era Faculty of Sciences of University of Porto (Bari, Italy)
2022/05/04	Development of new multitarget-directed ligands with potential application in Alzheimer’s disease	IJUP'22 - 15th Meeting of the young researchers of the University of Porto Faculty of Sciences of University of Porto (Porto, Portugal)
2022/04/27	Development of new multitarget-directed ligands with potential application in Alzheimer’s disease	XIV Scientific Seminar- 2nd cycle studies in chemistry Faculty of Sciences of the University of Porto (Porto, Portugal)
2021/12/09	Protective effects of the mitochondria-targeted antioxidant ANTIOXCIN4 against oxidative stress in the amyotrophic lateral sclerosis sod1g93a mouse	2nd International Conference on Neuroprotection by Drugs, Nutraceuticals, and Physical Activity (virtual meeting) Center for Neuroscience and Cell Biology (online)
2021/12/01	The Mitochondria-Targeted Antioxidant AntiOxCIN4 Protects Against Oxidative/Nitrosative Stress in the Amyotrophic Lateral Sclerosis SOD1GG3A Mouse	XVII Meeting of the Portuguese Society for Neuroscience, Coimbra, Portugal Centre for Neuroscience and Cell Biology (virtual meeting)
2021/12/01	Decrypting the Nfr2-dependent antioxidant protects against oxidative/nitrosative stress in the amyotrophic lateral sclerosis sod1g93a mouse	VII Meeting of the Portuguese Society for Neuroscience Centre for Neuroscience and Cell Biology (Coimbra, Portugal)
2021/10/14	Reverting cellular and mitochondrial defects in fibroblasts from sporadic Parkinson’s disease patients by using a new mitochondria-targeted antioxidant	International conference on Oxidative Stress, Redox Homeostasis and Antioxidants 2021 Centre for Neuroscience and Cell Biology (virtual meeting)
2021/10/07	Tackling antimicrobial resistance with novel phytochemical-based conjugates: a structure-activity-toxicity study	E-Conference on Innovation in Microbial Control Faculty of Engeneering of the University of Porto (virtual meeting)
2021/07/26	Development of new chemical entities based on natural scaffolds with therapeutic potential towards age-related disorders.	Paul Ehrlich Virtual Meeting 2021 Faculty of Sciences of the University of Porto (virtual meeting)
2021/06/09	Decrypting the Nrf2-dependent antioxidant mechanism of action behind the beneficial effcts of the mitochondriotropic cinnamic acid AntiOxCIN4	55th Annual meeting of he European Society for Clinical Investigation, “The Micro Me’s – Exploring microbiota in health and disease Centre for Neuroscience and Cell Biology (virtual meeting)
2021/06/09	Effect of novel mitochondria-targeted antioxidants in human skin fibroblasts	55th Annual meeting of the European Society for Clinical Investigation, The Micro Me's -Exploring microbiota in health and disease¿ Centre for Neuroscience and Cell Biology (virtual meeting)
2021/05/05	Evaluation of the effects of a TPP-based mitocan and two derivatives in ovarian and endometrial cancer cell lines	Encontro de Jovens Investigadores da Universidade do Porto (IJUP) Faculty of Sciences of the University of Porto (virtual meeting)
2021/04/23	The effects of a TPP-based compound and two derivatives in ovarian and endometrial cancer cells	Biotechnology and Synthetic Biology (BioSynBio) Faculty of Sciences of the University of Porto (virtual meeting)
2020/03/05	Mitochondriotropic Cinnamic Acid Antioxidant Improves Cellular Resistance to Stress (BEST ORAL COMMUNICATION)	MuTaLig COST ACTION CA1513, 4th WG meeting (Izmir, Turkey)
2020/02/22	The nanomaterial toolkit for neurological disorders treatment	II Workshop meeting CIQUP Faculty of Sciences of the University of Porto (Porto, Portugal)
2019/10/28	Antioxidant, hormetic-like properties of AntiOXCIN4, a novel hydroxycinnamic acid-based mitochondria-targeted agent	10th World Congress on Targeting Mitochondria (Berlim, Germany)
2019/06/13	Design and development of multi-target agents for neurodegenerative diseases	Paul Ehrlich Euro-PhD Network & MuTaLig COST Action (Catanzaro, Italy)
2019/06/13	PEGylation technology – the second chance for non-bioavailable drug candidates	IX Meeting of the Paul Ehrlich Euro-PhD Network & 4th Annual meeting – MuTaLig COST Action (Catanzaro, Italy)
2019/02/20	Improving the activity of dietary cinnamic and benzoic acids for the treatment of neurodegenerative disorders	26th Young Research Fellows meeting (Paris, France)
2019/02/08	Targeting Phenolic Dietary Antioxidants to Mitochondria to Modulate Redox Signaling and Metabolism	Portuguese Society of Pharmacology (Porto, Portugal)
2019/02/06	Mitochondriotropic antioxidants based on dietary hydroxycinnamic acids as an attempt to reduce skin aging	Portuguese Society of Pharmacology (Porto, Portugal)
2018/10/23	Mitochondria-targeted antioxidants in human hepatic cells: a conceivable therapy for non-alcoholic fatty liver disease	9th World Congress on Targeting Mitochondria (Berlim, Germany)
2018/10/18	History in the Making: development of multi-target-directed ligands for Alzheimer's disease that modulate oxidative stress/mitochondria quality and the cholinergic system	MuTaLig COST ACTION CA1513, WG meeting (Valletta, Malta)
2018/03/15	Mitochondriotropic antioxidants based on cinnamic acid derivatives increase celular stress responses in HepG2 cells	MuTaLig COST action (Tenerife, Spain)
2018/02/25	Skin mitohormesis by targeting hydroxycinnamic acid derivatives to mitochondria	9th International Conference on Skin Ageing & Challenges (Porto, Portugal)
2017/07/04	Drug biophysical profiling using lipid-based colloidal nanosystems and human serum albumin as biomimetic interfaces	VII Iberian Meeting on Colloids and Interfaces (RICI7) (Madrid, Spain)
2016/11/19	Targeting dietary antioxidants to mitochondria as a therapeutic solution for mitochondrial oxidative stress related diseases	6th Meeting of the Paul Ehrlich MedChem Euro-PhD Network and Mutalig COST Action, 1st WG meeting/ Poly-pharmacology expanding Paul Ehrlich’s magic bullet concept (Budapeste, Hungary)
2016/06/26	Development of bifunctional agents for ameliorating the oxidative stress associated with aging related diseases	36th Edition of the European School of Medicinal Chemistry (ESMEC) (Urbino, Italy)
2016/04/27	Mitohormesis: An attempt by targeting hydroxycinnamic acid derivatives to mitochondria	50th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) (Paris, France)
2016/04/26	Looking for new answers based on natural products for solving bacterial resistance problems	5th Meeting of Young Chemists (PYCheM) / 1st Meeting of Young Chemists (EYCHeM) (Guimarães, Portugal)
2015/07/02	Antioxidants: from Nature to drug prototypes	International Workshop on "Biochemistry, Physiology and Pharmacology of Oxidative Stress (Roma, Italy)
2015/05/13	Design and synthesis of novel antimicrobial agents inspired on phytochemicals	IJUP'15 - 8th Meeting of the young researchers of the University of Porto (Porto, Portugal)
2015/05/08	Caffeic acid: a natural scaffold for the development of new antimicrobial agents	2nd Symposium on Medicinal Chemistry of University of Minho (Braga, Portugal)
2014/06/05	MITOCIN’S - the Highway to Target Bioactive Cinnamic Molecules to Mitochondria	World Congress on Polyphenols Applications: ISANH Polyphenols (Lisboa, Portugal)
2013/09/27	Makeup of natural antioxidants: Design and development of smart carriers to deliver dietary phenolic acids to mitochondria	3rd Meeting of the Paul Ehrlich MedChem Euro-PhD Network Università degli Studi di Cagliari (Cagliari, Italy)
2013/04/17	Development of novel systems to delivery natural antioxidants to mitochondria: MitoCIN’s as a case study	47th Annual Scientific Meeting of the European Society for Clinical Investigation (ESCI) (Albufeira, Portugal)
2013/02/13	Spergularia rubra: A functional beverage to reduce overweight, obesity and diabetes	IJUP13- 6th Meeting of the young researchers of the University of Porto (Porto, Portugal)
2013/02/13	Bridging the gap between nature and antioxidant therapy: development of mitochondria-targeted antioxidants based on benzoic scaffold	IJUP13- 6th Meeting of the young researchers of the University of Porto (Porto, Portugal)
2013/02/13	Mitocondriotropics derivatives based on the natural polyphenol caffeic acid as a way out for oxidative stress related diseases	IJUP13- 6th Meeting of the young researchers of the University of Porto (Porto, Portugal)
2013/01/09	Development of Smart Carriers for delivering natural antioxidants to Mitochondria	2nd Workshop on Medicinal Chemistry Drug Discovery and Development: Understanding the R&D process Faculty of Sciences of the University of Porto (Porto, Portugal)
2012/03/28	Development of new lipophilic antioxidants based on cinnamic acid	5th Scientific Seminar- 2nd cycle studies in chemistry (FCUP) (Porto, Portugal)
2012/02/22	Development of innovative lipophilic hydroxycinnamic antioxidants: a solution to tackle mitochondrial oxidative damage	IJUP12- 5th Meeting of the young researchers of the University of Porto (Porto, Portugal)
2011/11/09	Striving for success in antioxidant therapy	10th Indo-Italian Workshop on Chemistry and Biology of Antioxidants (Roma, Italy)
2011/10/13	Opening a new avenue in neurodegenerative therapy: Mitochondria targeted antioxidants based on cinnamic scaffold	Angelini University awards 10/11 (Porto, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2023/04 - Current	De-ironing Friedreich’s Ataxia with innovative mitochondria-targeted chelators Supervisor of Carla Lima	Química (PhD) Universidade do Porto Faculdade de Ciências, Portugal
2022/10/01 - Current	Bona fide NOX2 inhibitors: a new therapeutic solution for neurodegenerative diseases Co-supervisor of Mariana Antunes Castelôa	Química (PhD) Universidade do Porto Faculdade de Ciências, Portugal
2023/09 - 2024/09	Desenvolvimento de Novos Quelantes de Ferro Direcionados à Mitocôndria com Potencial Aplicação da Ataxia de Friedreich Supervisor of Leticia Soares	Bioquímica (Master) Universidade do Porto Departamento de Química e Bioquímica, Portugal
2023/02 - 2023/09	TAILORING VAS2870 SCAFFOLD TO DEVELOP NEW COVALENT NOX2 INHIBITORS Co-supervisor of Vera Lúcia Amaral	Química (Degree) Universidade do Porto Faculdade de Ciências, Portugal
2022/11 - 2023/09	Desenvolvimento de novos agentes antibacterianos para combater as infeções hospitalares Supervisor of Catarina Alves	Química Medicinal (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2023/02 - 2023/07	Desenvolvimento novas estratégias para o tratamento da resistência aos antibióticos Supervisor of Joana Quadros Ferreira	Bioquímica (Degree) Universidade do Porto Faculdade de Ciências, Portugal
2022/10 - 2023/02	NOX2 como alvo terapêutico para desenvolvimento de novos fármacos para as doenças neurodegenerativas Co-supervisor of Andreia Ferreira	Bioquímica (Degree) Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2021/09/28 - 2022/12/07	Development of new multitarget-directed ligands with potential application in Alzheimer disease Supervisor of Carla Lima	Química (Master) Universidade do Porto Faculdade de Ciências, Portugal
2021/01 - 2022/12	Toxicological, neuroprotective and permeability evaluation of innovative Antiparkinsonian agents in cellular models Co-supervisor of Inês Cunha (Master Student)	Toxicologia Analítica Clínica e Forense (Master) Universidade do Porto Faculdade de Farmácia, Portugal
2020/09/14 - 2021/11/15	In vitro effects of mitochondria-targeted antioxidants in ovarian and endometrial cancer Co-supervisor of Mariana Antunes Castelôa	Bioquímica (Master) Universidade do Porto Faculdade de Ciências, Portugal
2021/03 - 2021/09	Evaluation of drug-like properties of innovative multitarget-directed ligands for treatment of Parkinson's disease Supervisor of Carolina Cunha	Bioengenharia (Master) Universidade do Porto Faculdade de Engenharia, Portugal
2021/02 - 2021/07	New insights into the development of selective bona fide NOX2 inhibitors Co-supervisor of Inês Libânio	Química (Degree) Universidade do Porto Faculdade de Ciências, Portugal
2020/02/03 - 2020/09/29	Development of new cationic antioxidants as a tool to tune the cytotoxic profile of mitochondriotropic antioxidants, Extracurricular internship (PEEC program), training in organic synthesis Supervisor of Carla Lima	Química (Degree) Universidade do Porto, Portugal
2020/02/03 - 2020/06/14	Design of smart carriers to target oxidative stress for Alzheimer disease Supervisor of Diana Pinho	Química (Degree) Universidade do Porto Faculdade de Ciências, Portugal
2016/12/04 - 2017/12/16	Synthesis of piperazine derivatives as acetylholinesterase inhibitors as a potential treatment of Alzheimer's disease Co-supervisor of Tânia Moura	Bioquímica (Degree) Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014/11/03 - 2015/07/15	Synthesis of new antioxidants and screening of AChE inhibitors Supervisor of João Handel de Oliveira	Química (Degree) Universidade do Porto Faculdade de Ciências, Portugal
2013/01/04 - 2013/06/04	Development of novel antioxidants, Extracurricular internship (PEEC program), training in organic synthesis Co-supervisor of Ana Francisca Coelho	Química (Degree) Universidade do Porto Faculdade de Ciências, Portugal
2012/06/02 - 2013/01/12	Looking for a therapeutic solution for Parkinson's Disease, Extracurricular internship (PEEC program), training in organic synthesis Co-supervisor of Andreia Carneiro	Bioquímica (Degree) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal Universidade do Porto Faculdade de Ciências, Portugal
2012/04/18 - 2012/10/22	Looking for a therapeutic solution for Parkinson's Disease, Extracurricular internship (PEEC program), training in organic synthesis Co-supervisor of Ana Bouçanova	Química (Degree) Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2023/06/26 - 2023/07/12	Co-organizer/Trainer of the international course - Erasmus+ Blended Intensive Programmes : Drug Discovery 2030: A Roadmap for a New Decade (2023/06/26 - 2023/07/12) Conference (Co-organisor)	Universidade do Porto Faculdade de Ciências, Portugal
2021/05/07 - 2021/05/09	Co-organizer of the First Webinar on Medicinal Chemistry - Designing Tomorrow´s Therapeutic - organized within the framework of the Medicinal Chemistry curricular unit and opened to the scientific community. (2021/05/07) Conference (Co-organisor)	Universidade do Porto Faculdade de Ciências, Portugal
2020/02/22 - 2020/02/22	II workshop meeting CIQ-UP (Chemistry Research Center of University of Porto) (2020/02/22 - 2020/02/22) Conference (Member of the Organising Committee)	Universidade do Porto Faculdade de Ciências, Portugal
2018/07/12 - 2018/07/14	VIII Meeting of the Paul Ehrlich MedChem EuroPhD Network & MuTaLig COST Action (2018/07/12 - 2018/07/14) Conference (Member of the Organising Committee)	Universidade do Porto Faculdade de Ciências, Portugal
2017/09/22 - 2017/09/24	EpiChemBio and 2nd annual MuTaLig COST actions joint meeting (2017/09/22 - 2017/09/24) Conference (Member of the Organising Committee)	Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2016/06/29 - 2016/07/01	10th World Congress on Polyphenols Applications (2016/06/26 - 2016/07/01) Conference (Member of the Organising Committee)	Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal
2014/05/30 - 2014/05/30	3rd Workshop in Medicinal Chemistry, Drug Discovery and Development: Understanding the R&D Process (2014/05/30 - 2014/05/30) Workshop (Member of the Organising Committee)	Universidade do Porto Faculdade de Ciências, Portugal
2014/02/12 - 2014/02/14	IJUP' 14 – 7th Meeting of the young researchers of University of Porto (2014/02/12 - 2014/02/14) Meeting (Member of the Organising Committee)	Universidade do Porto, Portugal
2013/01/09 - 2013/01/09	2nd Workshop on Medicinal Chemistry, Drug Discovery and Development: Understanding the R&D Process (2013/01/09 - 2013/01/09) Workshop (Member of the Organising Committee)	Universidade do Porto Faculdade de Ciências, Portugal
2011/06/12 - 2011/06/15	2nd Iberic Meeting on Medicinal Chemistry: G Protein-Coupled Receptors and Enzymes in Drug Discovery (2011/06/12 - 2011/06/15) Meeting (Member of the Organising Committee)	Universidade do Porto Faculdade de Ciências, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2019/11/01 - Current	Drug (re-)design guided by biophysical characterization of interactions with biomimetic membranes Congress	5th International Electronic Conference on Medicinal Chemistry MDPI AG, Switzerland
2014 - Current	Demonstration of the Chemistry and Biochemistry area of Faculty of Sciences, University of Porto in Mostra U. Porto Exhibition	Universidade do Porto, Portugal
2023/07/16 - 2023/07/18	XII Meeting of the Paul Ehrlich PhD NetWork Congress	Aristoteleio Panepistemio Thessalonikes Tmema Pharmakeutikes, Greece
2023/04/26 - 2023/04/26	Communication, dissemination and exploitation in R&D+i (Research, Development and Innovation) project applications for funding: conceptualization and strategies Workshop	Universidade do Porto, Portugal
2023/03/31 - 2023/04/03	ENEQUI - Encontro Nacional de Estudantes de Química Meeting	Universidade do Porto Faculdade de Ciências, Portugal
2022/11/16 - 2022/11/18	XXVI Encontro Galego-Portugués de Química Conference	Universidade de Santiago de Compostela Facultade de Química, Spain
2022/10/17 - 2022/10/17	How to protect a research result via patent and how to accommodate this protection in the proposal budget for funding Workshop	Universidade do Porto, Portugal
2022/06/06 - 2022/06/07	16th Annual Drug Discovery for Neurodegeneration Conference - Course on Translating Research into Novel Drug Targets Conference	Alzheimer's Drug Discovery Foundation, United States
2022/05/04 - 2022/05/06	Moderator in IJUP22 - 15º Encontro de Investigação Jovem da Universidade do Porto Meeting	Universidade do Porto Centro de Investigação em Química, Portugal
2021/10/07 - 2021/10/08	E-Conference on Innovation in Microbial Control Conference	Universidade do Porto Faculdade de Engenharia, Portugal Universidade do Porto Faculdade de Ciências, Portugal
2021/09/22 - 2021/09/24	Summer School in Pharmaceutical Analysis 2021: “Analytical methods to achieve efficiency in the hit-to-lead process Conference	Università degli Studi di Bologna, Italy
2021/07/26 - 2021/07/28	Paul Ehrlich Virtual Meeting 2021 Conference	Università degli Studi Magna Graecia di Catanzaro, Italy
2021/02/16 - 2021/02/17	1st symposium on Alzheimer Disease: an update on pathology and therapeutics Conference	Universidade do Porto Laboratorio de Engenharia de Processos Ambiente Biotecnologia e Energia, Portugal Universidade do Porto Faculdade de Ciências, Portugal
2021/01/28 - 2021/01/28	Webinar "How to use Microsoft Teams for distance learning activities" Workshop	Universidade do Porto Faculdade de Ciências, Portugal
2020/12/01 - 2020/12/01	Webinar "Back to Basics: Fundamental Concepts of HPLC & UHPLC" Workshop	VWR Foundation, United States
2020/07/30 - 2020/07/30	Webinar "Introducing - Mya 4 Reaction Station for reaction optimisation and process development" Workshop	Radleys Team, United Kingdom
2020/07/16 - 2020/07/16	Webinar "Improving cell-based assays and their future in drug discovery" Conference	Drug Target Review , Germany Fraunhofer Institut für Molekularbiologie und Angewandte Oekologie IME Institutsbereich Angewandte Oekologie, Germany
2020/03/05 - 2020/03/06	MuTaLig COST ACTION CA1513, 4th WG meeting Congress	Ege Üniversitesi Eczacilik Fakültesi, Turkey MuTaLig COST ACTION CA1513, Turquia, Turkey
2019/06/13 - 2019/06/15	Paul Ehrlich Euro-PhD Network & MuTaLig COST Action Congress	Complesso Monumentale San Giovanni, Italy Università degli Studi Magna Graecia di Catanzaro, Italy
2018/12/05 - 2018/12/07	3rd MuTaLig COST Action Training School Other	Fraunhofer-Institut für Molekularbiologie und Angewandte Oekologie IME Bereich Translationale Medizin Aussenstelle ScreeningPort, Germany
2018/10/18 - 2018/10/19	MuTaLig COST ACTION CA1513- WG meeting Congress	University of Malta, Malta
2017/11/27 - 2017/11/27	International dissemination event of the Toxicology MOOC (massive open online course) in the framework of the Erasmus+ Project TOX-OER- learning toxicology through open educational resources Other	Universidade do Porto Faculdade de Farmácia, Portugal
2017/09/22 - 2017/09/24	Joint EpiChemBio and MuTaLig COST Actions Meeting Congress	Universidade do Porto, Portugal
2016/11/19 - 2016/11/20	Mutalig COST Action, 1st WG meeting “Poly-pharmacology expanding Paul Elrlich’s magic bullet concept” Congress	Novotel Budapest Danube, Hungary
2016/06/26 - 2016/07/01	36th Edition of the European School of Medicinal Chemistry (ESMEC) Congress	Campus “Collegi del Colle e Tridente”, Italy
2015/02/04 - 2015/02/06	XXII Young Research Fellow Meeting Congress	Société de Chimie Thérapeutique, France
2014/06/20 - 2014/06/22	4th Meeting of the Paul Ehrlich MedChem Euro-PhD Network Congress	Univerzita Hradec Králové, Czech Republic
2014/03/17 - 2014/03/17	European Innovation Master Thesis competition 2017 Call	future Ideas
2013/11/13 - 2013/11/15	XIX Galician-Portuguese Chemistry Meeting Congress	Museu do Mar da Galiza, Spain
2013/09/04 - 2013/09/06	10th National Meeting of Organic Chemistry and 1st Luso-Brazilian Symposium on Organic Chemistry Symposium	Universidade de Lisboa Faculdade de Farmácia, Portugal
2013/05/17 - 2013/05/17	1st Symposium on Medicinal Chemistry Symposium	Universidade do Minho, Portugal
2013/05/09 - 2013/05/10	11st National Meeting of Physical Chemistry-11ENQF Symposium	Sociedade Portuguesa de Química, Portugal
2013/02/13 - 2013/02/15	IJUP’ 13 – 6th Meeting of the young researchers of University of Porto Meeting	Universidade do Porto, Portugal
2012/09/06 - 2012/09/09	16th Biennial Meeting of the Society for Free Radical Research International Congress	Imperial College London, United Kingdom
2012/05/23 - 2012/05/24	1st Chemical Shifts with the theme: "Química no mundo" Seminar	Universidade do Porto Faculdade de Ciências, Portugal
2012/02/22 - 2012/02/24	IJUP’ 12 – 5th Meeting of the young researchers of University of Porto Meeting	Universidade do Porto, Portugal
2011/10/13 - 2011/10/13	Angelini University awards 10/11 Meeting	Morada Angelini Farmacêutica Lda, Portugal
2011/02/17 - 2011/02/18	IJUP’ 11 – 4th Meeting of the young researchers of University of Porto Meeting	Universidade do Porto, Portugal
2010/12/17 - 2010/12/17	1st workshop in Medicinal Chemistry, Drug Discovery and Development: Understanding the R&D Process Workshop	Universidade do Porto Faculdade de Ciências, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2022/12	Toxicological, neuroprotective and permeability evaluation of innovative Antiparkinsonian agents in cellular models Supervisor	Inês Cunha (Master) Universidade do Porto Faculdade de Farmácia, Portugal
2022/12	Development of new multitarget-directed ligands with potential application in Alzheimer’s disease Supervisor	Carla Lima (Master) Universidade do Porto Faculdade de Ciências, Portugal
2022/07	Desenvolvimento de novos antibióticos baseados em ácidos benzoico e cinâmico para ameaças bacterianas da saúde pública atual (Thesis) Main arguer	Mariana da Silva Bastos (BsC student) (Other) Universidade do Porto Faculdade de Ciências, Portugal
2022/06/23	Targeting Cardiac Mitochondria with a New Generation of Multi-Purpose Cardioprotective Molecules (Thesis) Arguer	Caroline Veloso (PhD) Centre for Neuroscience and Cell Biology , Portugal
2021/10/12	Avaliação das propriedades antioxidantes dos ácidos fenólicos direcionados às mitocôndrias (Thesis) Main arguer	Beatriz da Silva Gonçalves (Master) Universidade da Beira Interior, Portugal
2021/07/12	Synthesis of new multi-target compounds with therapeutic potential for ALS (Thesis) Main arguer	Ana Rita Alfenim (BsC student) (Other) Universidade do Porto Faculdade de Ciências, Portugal
2020/07/21	Development of new bio-based antibiotics for the current public health bacterial threats (Thesis) Main arguer	Ana Margarida Duarte Pereira (BsC student) (Other) Universidade do Porto Faculdade de Ciências, Portugal

Association member

	Society Organization name	Role
2022/03/11 - Current	PT-OPENSCREEN - NORTE-01-0145-FEDER-085468: "Infraestrutura Nacional para a Química Biológica e Genética"
2022/03/11 - Current	EU-OPENSCREEN- European Research Infrastructure Consortium for chemical biology and early drug discovery
2013 - Current	Sociedade Portuguesa em Química
2011 - Current	Associate Laboratory - CIQUP/IMS - Institute of Molecular Sciences Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto
2016/04/18 - 2020/10/17	MuTaLig COST ACTION CA15135
2015/03/24 - 2019/03/23	EPICHEM Cost Action CM1406

Conference scientific committee

	Conference name	Conference host
2023 - Current	Conference scientific committee of the Erasmus+ Blended Intensive Programmes ¿ Drug Discovery 2030: A Roadmap for a New Decade	Faculty of Sciences of University of Porto
2021 - Current	Conference scientific committee of the First Webinar on Medicinal Chemistry - Designing Tomorrow´s Therapeutic	Faculty of Sciences of the University of Porto
2022/05/04 - 2022/05/06	Conference scientific committee of the IJUP22- 15th meeting of young researchers of University of Porto	Universidade do Porto

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2020/02 - Current	Invited Professor in Medicinal Chemistry classes	Chemistry and Biochemistry (Mestrado)	Universidade do Porto Faculdade de Ciências, Portugal
2023/02 - 2023/07	Project/internship	Química (Licenciatura)	Universidade do Porto Faculdade de Ciências, Portugal
2023/02 - 2023/07	Project/internship	Bioquímica (Licenciatura)	Universidade do Porto Faculdade de Ciências, Portugal
2022/10 - 2023/02	Project/ internship	Bioquímica (Licenciatura)	Universidade de Trás-os-Montes e Alto Douro, Portugal
2021/02 - 2021/07	Project/internship	Química (Licenciatura)	Universidade do Porto Faculdade de Ciências, Portugal
2017/12/06 - 2018	Invited Professor in Bioorganic Chemistry classes	Chemistry and Biochemistry (Licenciatura)	Universidade do Porto Faculdade de Ciências, Portugal
2014/03/03 - 2014/05/05	Assistent in practical classes of Medicinal Chemistry	Chemistry and Biochemistry (Mestrado)	Universidade do Porto Faculdade de Ciências, Portugal

Interview (tv / radio show)

	Program	Topic
2023/04/04 - Current	SIC Notícias	Portuguese researchers develop antioxidant to fight neurodegenerative diseases
2023/04/04 - Current	Jornal de Notícias	FCUP develops antioxidant with potential to fight neurodegenerative diseases
2023/04/04 - Current	Diário de Notícias	New developed antioxidant with potential to fight neurodegenerative diseases
2023/04/04 - Current	Radio Renascença	FCUP develops antioxidant with potential to fight neurodegenerative diseases
2023/04/04 - Current	CNN Portugal	Portuguese researchers develop antioxidant with potential to fight neurodegenerative diseases
2023/03/16 - Current	Notícias U.Porto and FCUP	How Lego Chemistry can help to fight neurodegenerative diseases
2018/06/06 - Current	UP Inovação - Mitotag	The use of antioxidants as a solution to fight age related diseases

Journal scientific committee

	Journal title (ISSN)	Publisher
2022/05 - Current	Peer review in Scientific Reports (2045-2322)	Nature
2021/01 - Current	Peer review in Molecules (1420-3049)	MDPI
2021 - Current	Peer review in European Journal of Clinical Investigation (1365-2362)	Wiley
2020/01/18 - Current	Peer review in Colloids and Surfaces B Biointerfaces (0927-7765)	Elsevier
2020 - Current	Peer review in Pharmacological Reports (1734-1140)	Springer
2020 - Current	Peer review in International Journal of Molecular Sciences (1422-0067)	MDPI
2022/09/15 - 2023/05/31	Guest editor in the Special Issue: "Advances in Drug Discovery Research in Europe", Molecules, https://www.mdpi.com/journal/molecules/special_issues/2PSM2TE9VP	MDPI AG
2020/07/07 - 2021/01/31	Guest editor in the Special Issue "Recent Advances in CNS Drug Discovery", Molecules, https://www.mdpi.com/journal/molecules/special_issues/CNS_Drug	MDPI

Mentoring / Tutoring

	Topic	Student name
2020/12/03 - Current	Dual-acting drugs targeting Ferroptosis and COMT: a new potential therapeutic strategy to fight Parkinson's Disease	Vera Silva (PhD Student)
2021/03/03 - 2024/02/01	Mitochondria-target antioxidants as novel therapeutics for Amyotrophic Lateral Sclerosis: Regulating Oxidative Stress and Apoptosis through modulation of the NFkB/HIF-1a axis	Cátia Silva Soares (PhD Student)
2023/04 - 2023/12	Biological evaluation of chemical compounds as anticancer and antioxidant agents	Jessica Ceramella - University of Calabria, Italy
2022/09 - 2023/06	Evaluation of iron chelation and cellular cytotoxicity of bioactive compounds	Uxia Bouzó (PhD student) - University of Vigo, Spain
2022/10/15 - 2023/05/14	Design and synthesis of new chemical entities based on VAS2870. BSc fellowship. Project NOXIous - Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure (EXPL/BIA-BQM/0492/2021) (7 months).	Carla Lima
2022/05/01 - 2022/09/30	Tailoring VAS27870 scaffold to develop new covalent NOX2 inhibitors. MSc fellowship (5 months). Project NOXIous - Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure (EXPL/BIA-BQM/0492/2021).	Mariana Antunes Castelôa
2022/04 - 2022/07	Development of antioxidants directed to mitochondria	Marco Francescato (Master student) - University of Bologna, Italy
2019/12/01 - 2020/12/01	Uso de fitoquímicos redox-activos para desencadear a hormesis mitocondrial: Desenvolvimento de uma nova geração de ingredientes para a cosmética	Brandon Aguiar (MsC fellow)
2019/09/02 - 2019/11/29	Short-Term Scientific Mission (STSM) of Cost Action CA15135 "Multi-target paradigm for innovative ligand identification in the drug discovery process (MuTaLig) in Chemistry	Jan Konecny (PhD student)- Univerzity of Pardubice, Czech Republic
2014/05/01 - 2015/05/31	Desenvolvimento de novos inibidores das proteínas quinases: um contributo para o tratamento da Esclerose Lateral Amiotrófica	Diogo Magalhães e Silva (BsC degree)

Other jury / evaluation

	Activity description	Institution / Organization
2023/03/20 - 2023/03/31	Effective member of the jury for the attribution of research grant (Pos-doc) under the project UIDB/00081/2020-RG1 to discover and develop new chemical entities with therapeutic potential for neurodegenerative and/or infectious diseases	Universidade do Porto Faculdade de Ciências, Portugal
2022/06/09 - 2022/06/27	Effective member of the jury for the attribution of research grant (Master degree) under the project "A Trojan horse strategy to discover and develop new antibacterials for superbugs" (EXPL/MED-QUI/1156/2021)	Universidade do Porto Faculdade de Ciências, Portugal
2019/10/30 - 2019/11/13	Effective member of the jury for the attribution of research grant (Master degree) under the project "SkinSHIELD 2" (POCI-01-0145-FEDER-028607)	Universidade do Porto Faculdade de Ciências, Portugal

Distinctions

Award

2024	Best article Prize (Modulating Cytotoxicity with Lego-like Chemistry: Upgrading Mitochondriotropic Antioxidants with Prototypical Cationic Carrier) in IACOBUS-Papers cross-border scientific collaboration between the northern region of Portugal and Galicia Xunta de Galicia, Spain
2022	Best Poster Communication Prize in 56th Annual Scientific Meeting, European Society for Clinical Investigation (ESCI), Itay, Bari
2022	Best Poster Communication Prize in X Meeting of the Paul Ehrlich Euro-PhD Network, Barcelona, Spain
2022	Research Fund: Principal Investigator of the FCT Project: "De-ironing Friedreich’s Ataxia with innovative mitochondria-targeted chelators" (2022.04633.PTDC) Fundação para a Ciência e a Tecnologia, Portugal
2021	Best article Prize (Exploring the Multi-Target Performance of Mitochondriotropic Antioxidants against the Pivotal Alzheimer’s Disease Pathophysiol) in IACOBUS-Papers cross-border scientific collaboration between the northern region of Portugal and Galicia Xunta de Galicia, Spain
2021	Research Fund: Co-Principal Investigator of the FCT Project: "Development of bona fide targeted covalent inhibitors to unravel NOX2 crystal structure" (EXPL/BIA-BQM/0492/2021 Fundação para a Ciência e a Tecnologia, Portugal
2020	Conference Grant from COST ACTION CA15135, Izmir, Turkey European Cooperation in Science & Technology , Izmir, Turkey
2020	Best Poster Communication Prize in Mu.Ta.Lig – COST ACTION CA15135, Izmir, Turkey MuTaLig COST ACTION CA1513, Turquia, Turkey
2020	Best Oral Communication Prize in Mu.Ta.Lig COST ACTION CA15135, Izmir, Turkey MuTaLig COST ACTION CA1513, Turquia, Turkey
2019	Best Poster Communication Prize in Mu.Ta.Lig – COST ACTION CA15135, Paris, France MuTaLig COST ACTION CA1513, France
2019	Conference Grant from COST ACTION CA15135 in conjunction with the Paul Ehrlich Euro-PhD Network, Catanzaro, Italy European Cooperation in Science & Technology , Catanzaro, Italy
2018	Conference Grant from COST ACTION CA15135, Valletta, Malta European Cooperation in Science & Technology , Valletta, Malta
2018	Course and Travel Grant: Grant for Cost Action multi-targeting biophysical training school to cover registration, accommodation and travel expenses at Fraunhofer- IME, Hamburg, Germany Fraunhofer-Verbund IUK-Technologie, Germany
2018	Best Poster Communication Prize in European Society for Clinical Investigation, Barcelona, Spain
2016	Best Poster Communication Prize in European School of Medicinal Chemistry, Urbino, Italy 36th Edition of European School of Medicinal Chemistry, Italy
2016	Course and Travel Grant: Grant for European School of Medicinal Chemist0ry (ESMEC) to cover registration, accommodation and travel expenses at Campus Collegi del Colle e Tridente, Urbino, Italy 36th Edition of European School of Medicinal Chemistry, Italy
2014	Career Grant: International Individual PhD Fellowship (SFRH/BD/99189/2013) (PT) Fundação para a Ciência e a Tecnologia, Portugal

Title

2019	Paul Ehrlich MedChem Euro-PhD in Medicinal Chemistry Label
2018	European Doctorate Universidade do Porto Faculdade de Ciências, Portugal

Other distinction

2022	Project Research Grant NORTE-01-0145-FEDER-085468 (PT)
2019	Project Research Grant POCI-01-0145-FEDER-029164 (PT)
2018	CCRN Fellowship NORTE-01-0145-FEDER-000028 (PT)
2018	Project Research Grant POCI-01-0145-FEDER-028607 (PT)
2013	FCT Fellowship PTDC/AGR-AAM/105044/2008 (PT)
2012	Erasmus Research Undergraduate Fellowship (EU) Universidade de Santiago de Compostela, Spain