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Karam Chand.
Identificação

Identificação pessoal

Nome completo
Karam Chand

Nomes de citação

  • Chand, Karam

Identificadores de autor

Ciência ID
1219-CDDD-43E6
ORCID iD
0000-0001-7691-4392
Google Scholar ID
https://scholar.google.com/citations?user=rg3ApO4AAAAJ&hl=en

Telefones

Telemóvel
  • (+46) 761521106 (Pessoal)

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2015
Concluído
 Química (Doutoramento)
Especialização em Sem especialidade
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Synthesis of Novel Pyridin-2-(1H)-one, benzopyran-2(1H)-one, and quinolin-2(1H)-one derivatives & sar study if their anticancer and antiplatelet activities" (TESE/DISSERTAÇÃO)
 Aprovado
2007/04/30 - 2013/01/04
Concluído
 Synthesis of novel pyridin-2(1H)-one,benzopyran- 2(1H)-one and quinolin-2(1H)-one derivatives & SAR study of their anticancer and antiplatelet activities (Doktor (PhD))
Especialização em Chemistry (Organic/Medicinal)
Chemistry Department, Universirty of Delhi, Delhi, India, Índia
"Synthesis of novel pyridin-2(1H)-one,benzopyran- 2(1H)-one and quinolin-2(1H)-one derivatives & SAR study of their anticancer and antiplatelet activities" (TESE/DISSERTAÇÃO)
 n/a
2013
Concluído
 PhD (Thesis entitled, “Synthesis of novel pyridin-2(1H)-one,benzopyran- 2(1H)-one and quinolin-2(1H)-one derivatives & SAR study of their anticancer and antiplatelet activities”,Thesis online Link http://shodhganga.inflibnet.ac.in/handle/10603/9018) (Doutoramento)
University of Delhi, Índia
"Synthesis of novel pyridin-2(1H)-one,benzopyran-" (TESE/DISSERTAÇÃO)
 n/a
2006
Concluído
 Master of Chemistry (Master)
Chemistry Department, Gurukula Kangri Vishwavidyalaya, Haridwar, India, Índia
"n/a" (TESE/DISSERTAÇÃO)
 First Class with 67% Marks
2006
Concluído
 MSc (Mestrado)
Gurkula Kangri University Haridwar, Índia
"n/a" (TESE/DISSERTAÇÃO)
 67%
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2015 - 2015 Investigador principal (carreira) (Investigação) Universidade de Lisboa Centro de Química Estrutural, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2016/07/07 - 2019/07/06 Postdoctoral Researcher. Herein, I am involved in synthesis of target molecules and tested them against different DNA G-quadruplex stabilization for finding new agents for treatment of cancer. Umea Universitet, Suécia
2016/07/07 - 2019/07/06 Postdoctoral Researcher. Herein, I m involved in synthesis of target molecules and tested them against different DNA G-quadruplex stabilization for finding new agents for treatment of cancer. Department of Chemistry, Umea University Sweden., Suécia
2015/10/01 - 2016/06/10 Worked as Research Fellow in the research grant of the Chemical Center Project Structural-QUI / 00100 IR at Insituto Superior Tecnico, University of Lisboa, Portugal under supervision Prof MA Santos Associação para o Desenvolvimento do Instituto Superior Técnico, Portugal
2015/10/01 - 2016/06/10 Worked as Research Fellow in the research grant of the Chemical Center Project Structural-QUI / 00100 IR at Insituto Superior Tecnico, University of Lisboa, Portugal under the supervision of Prof Mari Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2014/12/01 - 2015/09/30 Postdoctoral fellow through Erasmus Namaste Program for 10 months, and involved in tacrine based benzofuran, and 2-pyridone derivatives for the treatment of Alzheimer disease Associação para o Desenvolvimento do Instituto Superior Técnico, Portugal
2014/12/01 - 2015/09/30 Postdoctoral fellow through Erasmus Namaste Program for 10 months, and involved in tacrine based benzofuran, and 2-pyridone derivatives for the treatment of Alzheimer disease Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2014/03/10 - 2014/09/30 Research Scientist Synthesized two active Pharmaceutical Ingredients such as Rivaroxaban, Gadobenic acid (Multihance),via shorter, convenient and economical methods for the welfare of humans. Jubilant Life Sciences Ltd, Índia
2014/03/10 - 2014/09/30 Research Scientist Synthesized two active Pharmaceutical Ingredients such as Rivaroxaban, Gadobenic acid (Multihance),via shorter, convenient and economical methods for the welfare of humans. Jubilant Life Sciences Pvt Ltd, Noida, India, Índia
2013/01/28 - 2014/03/05 Research Scientist Involved in synthesis of various Active Pharmaceutical Ingredients such as Allylestrenol, Methandrostenolone, Progesterone, Ospemifene via shorter, convenient and economical methods Apeejay Stya University, Índia
2013/01/28 - 2014/03/05 Research Scientist Involved in synthesis of various Active Pharmaceutical Ingredients such as Allylestrenol, Methandrostenolone, Progesterone, Ospemifene via shorter, convenient and economical methods Apeejay Stya Research Foundation, Gurgaon, India, Índia
Projetos

Bolsa

Designação Financiadores
2014/12/01 - 2015/09/30 Tacrine and Pyridone/Benzofuran based hybrids for tackiling various aspects of Alzheimer's disease
Erasmus Namaste
Bolseiro de Pós-Doutoramento
Universidade de Lisboa Centro de Química Estrutural, Portugal
Concluído

Projeto

Designação Financiadores
2014/03/10 - 2014/11/21 Development and validation of new process for synthesis of Rivaroxaban drug for industerial plant scale
NA
Investigador
Jubilant Life Sciences Ltd, Índia
Concluído
2013/01/28 - 2014/03/05 Synthesis of various modified Steroids based drug molecules
NA
Investigador
Apeejay Stya University, Índia
Concluído
Produções

Publicações

Artigo em revista
  1. Chand, Karam. "Subtle structural alterations in G-quadruplex DNA regulate site specificity of fluorescence light-up probes". Nucleic Acids Research (2020): http://dx.doi.org/10.1093/nar/gkz1205.
    10.1093/nar/gkz1205
  2. Chand, Karam. "Quinazoline Ligands Induce Cancer Cell Death through Selective STAT3 Inhibition and G-Quadruplex Stabilization". Journal of the American Chemical Society (2020): http://dx.doi.org/10.1021/jacs.9b11232.
    10.1021/jacs.9b11232
  3. Marco Deiana; Karam Chand; Jan Jamroskovic; Ikenna Obi; Erik Chorell; Nasim Sabouri. "A Light-up Logic Platform for Selective Recognition of Parallel G-Quadruplex Structures via Disaggregation-Induced Emission". Angewandte Chemie International Edition 59 2 (2020): 896-902. https://doi.org/10.1002/anie.201912027.
    10.1002/anie.201912027
  4. Gaia Fancellu; Karam Chand; Daniel Tomás; Elisabetta Orlandini; Luca Piemontese; Diana F. Silva; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos. "Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease". Journal of Enzyme Inhibition and Medicinal Chemistry (2020): https://doi.org/10.1080/14756366.2019.1689237.
    10.1080/14756366.2019.1689237
  5. Chand, Karam. "Speciation Studies of Bifunctional 3-Hydroxy-4-Pyridinone Ligands in the Presence of Zn2+ at Different Ionic Strengths and Temperatures". Molecules (2019): http://dx.doi.org/10.3390/molecules24224084.
    10.3390/molecules24224084
  6. Rajeshwari Rajeshwari; karam Chand; Emanuel Candeias; Cardoso SM; Sílvia Chaves; M. A. Santos. "New Multitarget Hybrids Bearing Tacrine and Phenylbenzothiazole Motifs as Potential Drug Candidates for Alzheimer’s Disease". Molecules (2019): http://www.mdpi.com/1420-3049/24/3/587.
    10.3390/molecules24030587
  7. Valeria M. Nurchi; Rosita Cappai; Karam Chand; Sílvia Chaves; Lurdes Gano; Guido Crisponi; Massimiliano Peana; M. Antonietta Zoroddu; M. Amélia Santos. "New strong extrafunctionalizable tris(3,4-HP) and bis(3,4-HP) metal sequestering agents: synthesis, solution and in vivo metal chelation". Dalton Transactions (2019): https://doi.org/10.1039/C9DT02905B.
    10.1039/C9DT02905B
  8. Asha Hiremathad; Karam Chand; Lori Tolayan; Rajeshwari; Rangappa S. Keri; A. Raquel Esteves; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos. "Hydroxypyridinone-benzofuran hybrids with potential protective roles for Alzheimer´s disease therapy". Journal of Inorganic Biochemistry 179 (2018): 82-96. https://doi.org/10.1016%2Fj.jinorgbio.2017.11.015.
    10.1016/j.jinorgbio.2017.11.015
  9. Irto, A.; Cardiano, P.; Chand, K.; Cigala, R.M.; Crea, F.; De Stefano, C.; Gano, L.; et al. "New bis-(3-hydroxy-4-pyridinone)-NTA-derivative: Synthesis, binding ability towards Ca2+, Cu2+, Zn2+, Al3+, Fe3+ and biological assays". Journal of Molecular Liquids 272 (2018): 609-624. http://www.scopus.com/inward/record.url?eid=2-s2.0-85054159311&partnerID=MN8TOARS.
    10.1016/j.molliq.2018.09.107
  10. Karam Chand; Rajeshwari Rajeshwari; Emanuel Candeias; Sandra M. Cardoso; Sílvia Chaves; M. Amélia Santos; Chand, K.; et al. "Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug". Metallomics 10 10 (2018): 1460-1475. https://doi.org/10.1039/C8MT00143J.
    10.1039/C8MT00143J
  11. Irto, A.; Cardiano, P.; Chand, K.; Cigala, R.M.; Crea, F.; De Stefano, C.; Gano, L.; Sammartano, S.; Santos, M.A.. "Bifunctional 3-hydroxy-4-pyridinones as effective aluminium chelators: synthesis, solution equilibrium studies and in vivo evaluation". Journal of Inorganic Biochemistry 186 (2018): 116-129. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048173019&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2018.05.017
  12. Hiremathad, A.; Chand, K.; Keri, R.S.. "Development of coumarin–benzofuran hybrids as versatile multitargeted compounds for the treatment of Alzheimer’s Disease". Chemical Biology and Drug Design 92 2 (2018): 1497-1503. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050492673&partnerID=MN8TOARS.
    10.1111/cbdd.13316
  13. Cappai, R.; Chand, K.; Lachowicz, J.I.; Chaves, S.; Gano, L.; Crisponi, G.; Nurchi, V.M.; et al. "A new tripodal-3-hydroxy-4-pyridinone for iron and aluminium sequestration: Synthesis, complexation and: In vivo studies". New Journal of Chemistry 42 10 (2018): 8050-8061. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047058918&partnerID=MN8TOARS.
    10.1039/c8nj00116b
  14. Rangappa S. Keri; Karam Chand; Srinivasa Budagumpi; Sasidhar Balappa Somappa; Siddappa A. Patil; Bhari Mallanna Nagaraja. "An overview of benzo [b] thiophene-based medicinal chemistry". European Journal of Medicinal Chemistry 138 (2017): 1002-1033. https://doi.org/10.1016%2Fj.ejmech.2017.07.038.
    10.1016/j.ejmech.2017.07.038
  15. Suchita Prasad; Bipul Kumar; Shiv Kumar; Karam Chand; Shashank S. Kamble; Hemant K. Gautam; Sunil K. Sharma. "Acetamide Derivatives of Chromen-2-ones as Potent Cholinesterase Inhibitors". Archiv der Pharmazie 350 8 (2017): 1700076-1700076. https://doi.org/10.1002%2Fardp.201700076.
    10.1002/ardp.201700076
  16. Vipan Kumar; Karam Chand; Erik Chorell. "Synthesis of Various N-Substituted 4-Aryloxy/Thiophenoxy/Thioisopropyloxy-Phthalimides". ChemistrySelect 2 11 (2017): 3293-3296. https://doi.org/10.1002%2Fslct.201700721.
    10.1002/slct.201700721
  17. Karam Chand; Rajeshwari; Asha Hiremathad; Mahak Singh; M. Amelia Santos; Rangappa S. Keri. "A review on antioxidant potential of bioactive heterocycle benzofuran: Natural and synthetic derivatives". Pharmacological Reports 69 2 (2017): 281-295. https://doi.org/10.1016%2Fj.pharep.2016.11.007.
    10.1016/j.pharep.2016.11.007
  18. M. Amélia Santos; Karam Chand; Silvia Chaves. "Recent progress in multifunctional metal chelators as potential drugs for Alzheimer's disease". Coordination Chemistry Reviews 327-328 (2016): 287-303. https://doi.org/10.1016%2Fj.ccr.2016.04.013.
    10.1016/j.ccr.2016.04.013
  19. M Amélia Santos; Karam Chand; Sílvia Chaves. "Recent progress in repositioning Alzheimer's disease drugs based on a multitarget strategy". Future Medicinal Chemistry 8 17 (2016): 2113-2142. https://doi.org/10.4155%2Ffmc-2016-0103.
    10.4155/fmc-2016-0103
  20. Karam Chand; Hesham M. Alsoghier; Sílvia Chaves; M. Amélia Santos. "Tacrine-(hydroxybenzoyl-pyridone) hybrids as potential multifunctional anti-Alzheimer's agents: AChE inhibition, antioxidant activity and metal chelating capacity". Journal of Inorganic Biochemistry 163 (2016): 266-277. https://doi.org/10.1016%2Fj.jinorgbio.2016.05.005.
    10.1016/j.jinorgbio.2016.05.005
  21. Atul Kumar Sharma; Preeti Yadav; Karma Chand; Sunil K. Sharma. "ChemInform Abstract: Synthesis and Characterization of New N-Alkylated Pyridin-2(1H)-ones.". ChemInform 47 40 (2016): https://doi.org/10.1002%2Fchin.201640162.
    10.1002/chin.201640162
  22. Asha Hiremathad; Karam Chand; A. Raquel Esteves; Sandra M. Cardoso; Rona R. Ramsay; Sílvia Chaves; Rangappa S. Keri; M. Amélia Santos. "Tacrine-allyl/propargylcysteine–benzothiazole trihybrids as potential anti-Alzheimer's drug candidates". RSC Advances 6 58 (2016): 53519-53532. https://doi.org/10.1039%2Fc6ra03455a.
    10.1039/c6ra03455a
  23. Sharma, A.K.; Yadav, P.; Chand, K.; Sharma, S.K.. "Synthesis and characterization of new N-alkylated pyridin-2(1H)-ones". Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry 55B 4 (2016): 492-500. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009271602&partnerID=MN8TOARS.
  24. Chand,Karam; Biswas,Sanchay Kumar; Sharma,Gaurav; Saxena,Arpit; Tewari,Neha; Mahajan,Sonalika; Pandey,Awadh Bihari. "Full genome sequencing of the bluetongue virus-1 isolate MKD20/08/Ind from goat in India". (2016): http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000300527.
  25. Karam Chand; Atul K. Sharma; Sunil K. Sharma. "Synthesis,1H and13C NMR assignment of novel 2-pyridone derivatives". Magnetic Resonance in Chemistry 54 1 (2015): 91-102. https://doi.org/10.1002%2Fmrc.4321.
    10.1002/mrc.4321
  26. Rangappa S. Keri; Karam Chand; Thippeswamy Ramakrishnappa; Bhari Mallanna Nagaraja. "Recent Progress on Pyrazole Scaffold-Based Antimycobacterial Agents". Archiv der Pharmazie 348 5 (2015): 299-314. https://doi.org/10.1002%2Fardp.201400452.
    10.1002/ardp.201400452
  27. Preeti Yadav; Hardeep Gill; Karam Chand; Lian Li; Jayant Kumar; Sunil Sharma. "Synthesis and Sensing Applications of Fluorescent 3-Cinnamoyl Coumarins". Sensors 15 12 (2015): 31987-31998. https://doi.org/10.3390%2Fs151229902.
    10.3390/s151229902
  28. Asha Hiremathad; Mahadeo R. Patil; Chethana K. R.; Karam Chand; M. Amelia Santos; Rangappa S. Keri. "Benzofuran: an emerging scaffold for antimicrobial agents". RSC Advances 5 117 (2015): 96809-96828. https://doi.org/10.1039%2Fc5ra20658h.
    10.1039/c5ra20658h
  29. Praveen Vats; Vera Hadjimitova; Krassimira Yoncheva; Abha Kathuria; Antara Sharma; Karam Chand; Arul J. Duraisamy; et al. "Chromenone and quinolinone derivatives as potent antioxidant agents". Medicinal Chemistry Research 23 11 (2014): 4907-4914. https://doi.org/10.1007%2Fs00044-014-1054-5.
    10.1007/s00044-014-1054-5
  30. Karam Chand; Rakesh K Tiwari; Sumit Kumar; Amir Nasrolahi Shirazi; Sweta Sharma; Erik V Van der Eycken; Virinder S Parmar; Keykavous Parang; Sunil K Sharma. "Synthesis, Antiproliferative, and c-Src Kinase Inhibitory Activities of 4-Oxo-4H-1-benzopyran Derivatives". Journal of Heterocyclic Chemistry 52 2 (2014): 562-572. https://doi.org/10.1002%2Fjhet.2106.
    10.1002/jhet.2106
  31. Karam Chand; Suchita Prasad; Rakesh K. Tiwari; Amir N. Shirazi; Sumit Kumar; Keykavous Parang; Sunil K. Sharma. "Synthesis and evaluation of c-Src kinase inhibitory activity of pyridin-2(1H)-one derivatives". Bioorganic Chemistry 53 (2014): 75-82. https://doi.org/10.1016%2Fj.bioorg.2014.02.001.
    10.1016/j.bioorg.2014.02.001
  32. Karam Chand; Amir Nasrolahi Shirazi; Preeti Yadav; Rakesh K. Tiwari; Meena Kumari; Keykavous Parang; Sunil K. Sharma. "Synthesis and antiproliferative and c-Src kinase inhibitory activities of cinnamoyl- and pyranochromen-2-one derivatives". Canadian Journal of Chemistry 91 8 (2013): 741-754. https://doi.org/10.1139%2Fcjc-2013-0053.
    10.1139/cjc-2013-0053
  33. Abha Kathuria; Nivedita Priya; Karam Chand; Prabhjot Singh; Anjali Gupta; Sarah Jalal; Shilpi Gupta; Hanumantharao G. Raj; Sunil K. Sharma. "Substrate specificity of acetoxy derivatives of coumarins and quinolones towards Calreticulin mediated transacetylation: Investigations on antiplatelet function". Bioorganic & Medicinal Chemistry 20 4 (2012): 1624-1638. https://doi.org/10.1016%2Fj.bmc.2011.11.016.
    10.1016/j.bmc.2011.11.016
  34. Sarah Jalal; Karam Chand; Abha Kathuria; Prabhjot Singh; Nivedita Priya; Bhavna Gupta; Hanumantharao G. Raj; Sunil K. Sharma. "Calreticulin transacetylase: A novel enzyme-mediated protein acetylation by acetoxy derivatives of 3-alkyl-4-methylcoumarins". Bioorganic Chemistry 40 (2012): 131-136. https://doi.org/10.1016%2Fj.bioorg.2011.10.005.
    10.1016/j.bioorg.2011.10.005
  35. S. K. Sharma; S. Kumar; K. Chand; A. Kathuria; A. Gupta; R. Jain. "An Update on Natural Occurrence and Biological Activity of Chromones". Current Medicinal Chemistry 18 25 (2011): 3825-3852. https://doi.org/10.2174%2F092986711803414359.
    10.2174/092986711803414359
  36. Sharma, S.K.; Kumar, S.; Chand, K.; Kathuria, A.; Gupta, A.; Jain, R.. "An update on natural occurrence and biological activity of chromones". Current Medicinal Chemistry 18 25 (2011): 3825-3852. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052246572&partnerID=MN8TOARS.
  37. Anjali Gupta; Nivedita Priya; Sarah Jalal; Prabhjot Singh; Karam Chand; Hanumantharao G. Raj; Virinder S. Parmar; Anthony L. DePass; Sunil K. Sharma. "Specificity of Calreticulin Transacetylase to acetoxy derivatives of benzofurans: Effect on the activation of platelet Nitric Oxide Synthase". Biochimie 92 9 (2010): 1180-1185. https://doi.org/10.1016%2Fj.biochi.2010.06.011.
    10.1016/j.biochi.2010.06.011
  38. Nivedita Priya; Anjali Gupta; Karam Chand; Prabhjot Singh; Abha Kathuria; Hanumantharao G. Raj; Virinder S. Parmar; Sunil K. Sharma. "Characterization of 4-methyl-2-oxo-1,2-dihydroquinolin-6-yl acetate as an effective antiplatelet agent". Bioorganic & Medicinal Chemistry 18 11 (2010): 4085-4094. https://doi.org/10.1016%2Fj.bmc.2010.04.011.
    10.1016/j.bmc.2010.04.011

Outros

Invenção
  1. An improved process for the preparation of rivaroxaban. 2017. Chand, Karam.
Distinções

Prémio

2009 Awarded Junior Research Fellowship in the DU-DST Research Project under the supervision of Prof. Sunil K Sharma. January 2010- March 2011.
University of Delhi, Índia

Outra distinção

2016 Postdoctoral Fellowship at Umea University Sweden. Started July2016-Present
2015 Awarded with CQE Research Fellow grant under Project Structural-QUI / 00100 IR at Insituto Superior Tecnico, University of Lisboa, Portugal. October 2015-June 216
2014 Awarded Star employee for the month of July 2014 by Jubilant Life Sciences Pvt Ltd Noida, India for the outstanding contribution for the organisation. March 2015-November 2014.
2014 Postdoctoral fellowship for 10 months through Erasmus Mundus Namaste program started from December 2014-September 2015
2012 Awarded travel grant including all expenses to present Poster related to my research work by Freie Universität Berlin
2011 Awarded Senior Research Fellowship (SRF) by Council of Scientific and Industrial Research (CSIR) India. started from April 2011-January2013.
Council of Scientific and Industrial Research (CSIR) India, Índia