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Mário Grãos obtained a PhD degree in Biology (Cell Biology) in 2006 from the Faculty of Sciences - U. of Lisbon (Portugal), having developed his thesis at the Gulbenkian Institute of Science (Oeiras, Portugal). Obtained a BSc degree in Biochemistry in 1999 from the Faculty of Sciences and Technology - U. of Coimbra (Portugal). His main research field is Cell and Molecular Biology, with more recent work on Cell Mechanobiology with emphasis on neurodegenerative diseases and stem cells. Is particularly interested in understanding the molecular mechanisms and signaling pathways responsible for integrating biophysical (mechanotransduction) and biochemical stimuli involved in cellular patho/physiological processes, cell survival & differentiation, cell potency & reprogramming, regulation of the cytoskeleton & cellular proteome. Current models include adult & pluripotent stem cells, primary neurons & oligodendrocytes and cell lines relevant to study neurodegenerative diseases (namely multiple sclerosis and Alzheimer's disease) and explore regenerative and precision medicine. This is articulated with the development of platforms that mimic mechanical and biochemical components of the extracellular matrix to perform ex vivo studies, suitable for the culture of primary cells and cell lines. Published 29 articles in international peer-reviewed journals (5 as corresponding senior author) and 3 book chapters, with over 2100 citations, i10 index 23, h-index 19 (https://scholar.google.pt/citations?hl=en&user=6dlIqxgAAAAJ&view_op=list_works&sortby=pubdate). Publications include Nature Communications, Cell Death & Differentiation, Nanoscale Horizons, Redox Biology, J. Neuroscience, Frontiers in Cell and Developmental Biology, and Frontiers in Cellular Neuroscience. The 2006-2008 period denotes a productivity gap resulting from his initial period at Biocant and the setting-up of the laboratory and the institution itself (Biocant initiated activities in Sep/2005), not having had a typical Post- Doctoral period after the PhD degree, but rather being a contracted researcher at Biocant. This was coincident with becoming a parent for the first time (Dec/2005). The productivity in 2017/2018 was also affected (1 book chapter in 2017) by parenting responsibilities of a second newborn child (Apr/2017). Has been recipient of 15 research grants (total funding over 3.85M EUR), 3 as PI and 3 as co-PI (1.244.630,77 EUR), and 9 as researcher (2.065.888 EUR). Has received 2 fellowships: PhD fellowship from FCT SFRH/BD/2729/2000 (in 2000); and a PGDBM (Gulbenkian PhD Program in Biology and Medicine) fellowship from the Gulbenkian Foundation/FLAD/FCT (in 1999). Has completed the supervision of 2 PhD students, 1 Post-doctoral fellow, 9 MSc students and 4 undergraduate students. Was examiner of 6 PhD and 15 MSc theses defenses. Has performed as peer reviewer of at least 29 manuscripts submitted to international journals, including Advanced Science, Advanced Biosystems, Acta Biomaterialia, Biomaterials Science, Stem Cells. Teaching activities include lectures on the topics of Mechanotransduction and modulation of cell fate, Mechanobiology and neurodegenerative diseases, Apoptosis and other mechanobiology and cell biology related topics in PhD and MSc programs (mostly at the U. of Coimbra) and other advanced courses. Was involved in several outreach and educational activities for science dissemination to the community, including talks for high school students, teachers, elderly and population in general, including activities & courses promoted by IEC and Brain Awareness Week.
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Identificação

Identificação pessoal

Nome completo
MÁRIO MARTINS RODRIGUES GRÃOS

Nomes de citação

  • Grãos, Mário
  • Grãos, M

Identificadores de autor

Ciência ID
131F-F27A-6066
ORCID iD
0000-0002-2707-1488

Endereços de correio eletrónico

  • mgraos@gmail.com (Profissional)

Telefones

Fax
  • 231419049 (Profissional)
Telefone
  • 231419040 (Profissional)

Moradas

  • Center for Neuroscience and Cell Biology of Coimbra (CNC) - UC-Biotech. Parque Tecnológico de Cantanhede, Núcleo 04, Lote 8, 3060-197, Cantanhede, Cantanhede, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Patologia
  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português (Idioma materno)
Espanhol; Castelhano Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1)
Formação
Grau Classificação
2006/06/28
Concluído
 Biology (Doutoramento)
Especialização em Cell Biology
Universidade de Lisboa Faculdade de Ciências, Portugal
"Regulation of Pro-apoptotic Protein Bim in Cell-cycle and Stress - Regulação da Proteina Pro-apoptótica Bim no Ciclo Celular e em Stress" (TESE/DISSERTAÇÃO)
 Unanimous “Pass With Honors”
1999/06/28
Concluído
 Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Protective Effects of Neurotrophins Against Excitotoxic Cell Death in the Hippocampus: Role of Different Signaling Pathways" (TESE/DISSERTAÇÃO)
 16/20
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2014/10/01 - Atual Investigador Auxiliar (carreira) (Investigação) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2005/07/01 - 2021/07/31 Investigador Contratado (Investigação) Biocant Associação de Transferência de Tecnologia, Portugal
2001 - 2001 Investigador visitante (Investigação) Imperial College Faculty of Medicine - Hammersmith Campus, Reino Unido

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2017/09 - 2021/06/30 Local Health & Safety Officer at the CNC (at UC Biotech) for Cell Culture Rooms Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/08/01 - 2023/04/01 Chief Operating Officer (COO) Coimbra Genomics SA, Portugal
2000/10/01 - 2005/02/28 PhD. student Instituto Gulbenkian de Ciência, Portugal
1999/09/01 - 2000/09/30 Gulbenkian PhD. Program (PGDBM) student Instituto Gulbenkian de Ciência, Portugal
1998/09/01 - 1999/07/31 Undergraduate Research Trainee Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projetos

Bolsa

Designação Financiadores
2019 - Atual CIBB Strategic Project
UIDB/04539/2020
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Em curso
2018/08 - 2021/07 BrEin-MS — Brain Elasticity in Multiple Sclerosis and implications in mechanomodulation of oligodendrocytes: a cellular and clinical approach
POCI-01-0145-FEDER-029516
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2018/08 - 2021/07 New approaches on Hypoxic-Ischemic Encephalopathy: translational research to diagnose and monitor stem cell therapy
POCI-01-0145-FEDER-029311
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2017/02 - 2021/01 Synaptic networks and Personalized Medicine Approaches to Understand Neurobehavioural Diseases Across the Lifespan
SAICTPAC/0010/2015
Investigador
Universidade de Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2016/10 - 2019/09 Novel cerebrospinal fluid and serum biomarkers for Multiple Sclerosis
RG-1601-07502
Investigador
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 National Multiple Sclerosis Society
Concluído
2013/05 - 2015/04 DJ-1 neuronal rescue under oxidative stress: implications for Parkinson's disease
124354
Provided by PTCRIS: 124354
Investigador
Biocant Associação de Transferência de Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2012/05 - 2015/04 Personalized 3D vascular constructs for toxicity assessment- VASCTOX
Provided by PTCRIS: 121887
121887
Investigador responsável
Biocant Associação de Transferência de Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
2012/05 - 2015/04 Differentiation of mesenchymal stem cells to oligodendroglial lineage: complementary roles of soluble factors, extracellular matrix and mechanotransduction
Provided by PTCRIS: 119292
119292
Investigador responsável
Biocant Associação de Transferência de Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2012/03 - 2015/02 Modulation of induced pluripotent stem cells differentiation by carbon nanotube templates - StemCelCan
119184
Provided by PTCRIS: 119184
Investigador
Biocant Associação de Transferência de Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
2009/01 - 2012/06 Early Diagnosis of Alzheimer´s Disease: evaluation of recent classification criteria and proposal of new diagnostic tools
Provided by PTCRIS: 83206
83206
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2010 - 2011 Retroviral-like membrane-associated aspartic proteinases from Rickettsiae. Potential new therapeutic targets for rickettsioses
PTDC/SAU-MII/107942/2008
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2007 - 2010 Identification of biomarkers for Multiple Sclerosis in the cerebrospinal fluid and serum
Agreement Number 10507
Investigador
Biocant Associação de Transferência de Tecnologia, Portugal
 Biogen Portugal
Concluído
2002 - 2005 Molecular mechanisms of microtubule mediated signalling under oxidative stress
POCTI/BCI/42249/2001
Bolseiro de Doutoramento
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2019/07 - 2021/12 MSCellProduction
POCI-01-0247-FEDER-038313
Investigador responsável
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Em curso
2010 - 2012 ISOCORD-Isolation, characterization, expansion and differentiation of mesenchymal stem cells derived from the umbilical cord blood and matrix
CENTRO – 07-0202 –FEDER –005547
Investigador responsável
Biocant Associação de Transferência de Tecnologia, Portugal
 Comissão de Coordenação e Desenvolvimento Regional do Centro
2008 - 2008 Effect of the press juice of Bryophyllum pinnatum on the activity of the calcium channels of human myometrial cells in vitro
N/A
Investigador
Biocant Associação de Transferência de Tecnologia, Portugal
 Weleda AG
Concluído
Produções

Publicações

Artigo em conferência
  1. Neves, Margarida; Grãos, Mário; Manadas, Bruno; Anjo, Sandra I.. "oxSWATH applied to the study of the alteration of intracellular and extracellular proteome of cells in response to oxidative stress". Trabalho apresentado em SFRR-INTERNATIONAL 2021 VIRTUAL MEETING, 2021.
    Publicado
  2. Sandra I. Anjo; Matilde Melo; Liliana Loureiro; Lúcia Sabala; Nuno Jordão; Vera Mendes; Tiago Faria; et al. "Deciphering DJ-1 neuroprotective mechanisms in response to oxidative stress by revealing its dynamic interactome". Trabalho apresentado em SFRR-E 2019 ANNUAL MEETING “REDOX HOMEOSTASIS: FROM SIGNALING TO DAMAGE”, 2019.
    Publicado
  3. Tânia Lourenço; Ana M. Falcão; Gonçalo Castelo-Branco; Grãos, Mário. "Epigenetic mechanisms underlying oligodendrocyte differentiation enhanced by mechanotransduction". Trabalho apresentado em EuroGlia, Porto, Portugal 2019, 2019.
    Publicado
  4. Sandra I. Anjo; Matilde N. Melo; Liliana R. Loureiro; Lúcia Sabala; Pedro Castanheira; Grãos, Mário; Bruno Manadas. "oxSWATH: an integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening". Trabalho apresentado em Free Radical Biology and Medicine, 2018.
    Publicado
  5. Sandra I. Anjo; Vera Mendes; Grãos, Mário; Bruno Manadas. "Monitoring oxidative stress and progression to cell death: From secretome to blood diagnosis". Trabalho apresentado em International Parkinson and Movement Disorder Society, 2016.
    Publicado
  6. Pereira, Sandro; Grãos, Mário; Sandra I. Anjo; Rui Carvalho; Paulo J. Oliveira; Ernest Arenas; João Ramalho-Santos. "Modulation of mitochondrial activity by antimycin a blocks neuronal differentiation and maintains embryonic stem cell pluripotency". Trabalho apresentado em EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 43, 2013.
    Publicado
  7. Vazão, H.; Neves, R.; Grãos, M.; Ferreira, L.. "Towards the maturation and characterization of smooth muscle cells derived from human embryonic stem cells". 2011.
    Publicado
  8. Amaral, A. P.; Andreia Ribeiro; Isabel Velada; Sandrine Mendes; Grãos, Mário; Carla Cardoso; Cláudia da Silva Lobato; et al. "Umbilical Cord Matrix Mesenchymal Stem Cells Exhibit a Lower Ability to Inhibit T Cell Activation, Proliferation, Differentiation to Th1 Subtype and to Induce Regulatory T Cells". Trabalho apresentado em AABB Annual Meeting and CTTXPO, San Diego, CA, 2011.
    Publicado
  9. João Maia; Helena Vazão; Dora Pedroso; Carlos Jesus; Rui Brito; Grãos, Mário; Helena Gil; Lino Ferreira. "Dual pro-angiogenic therapy based on the release of VEGF165 and endothelial cells derived from umbilical cord stem cells in a hybrid network". 2011.
    Publicado
  10. Henriques, A.; Silva, I.; Inacio, M.; Andreia Ribeiro; Isabel Velada; Grãos, Mário; Carla Cardoso; et al. "Immunomodulatory ability of umbilical cord matrix mesenchymal stem cells to inhibit T cells proliferation, activation, and differentiation". 2011.
    Publicado
  11. Simões-Wüst, A. P.; Grãos, Mário; Duarte, CB; Brenneisen, R.; Hamburger, M.; Mennet, M.; Schnelle, M.; et al. "Potential of a combined tocolysis with Bryophyllum pinnatum (Lam.) and nifedipine". 2010.
    Publicado
  12. Simões-Wüst, AP; Grãos, Mário; Duarte, CB; Brenneisen, R.; Hamburger, M.; Mennet, M.; Ramos F. M. H.; et al. "Press Juice of Bryophyllum pinnatum (Lam.) Inhibits Oxytocin-Induced Increase of the Intracellular Calcium Concentration in Human Myometrial Cells". 2009.
    Publicado
Artigo em revista
  1. Caramelo, Inês; Coelho, Margarida; Rosado, Miguel; Cardoso, Carla M. P.; Dinis, Alexandra; Duarte, Carlos B.; Grãos, Mário; Manadas, Bruno. "Biomarkers of hypoxic-ischemic encephalopathy: a systematic review". World Journal of Pediatrics 19 6 (2023): 505-548. http://dx.doi.org/10.1007/s12519-023-00698-7.
    10.1007/s12519-023-00698-7
  2. Serrenho, Inês; Cardoso, Carla M.; Grãos, Mário; Dinis, Alexandra; Manadas, Bruno; Baltazar, Graça. "Hypothermia Does Not Boost the Neuroprotection Promoted by Umbilical Cord Blood Cells in a Neonatal Hypoxia-Ischemia Rat Model". International Journal of Molecular Sciences 24 1 (2022): 257. http://dx.doi.org/10.3390/ijms24010257.
    10.3390/ijms24010257
  3. Neves, Margarida; Grãos, Mário; Anjo, Sandra I.; Manadas, Bruno. "Modulation of signaling pathways by DJ-1: An updated overview". Redox Biology 51 (2022): 102283. http://dx.doi.org/10.1016/j.redox.2022.102283.
    10.1016/j.redox.2022.102283
  4. Salazar, Ivan L.; Lourenço, Ana S. T.; Manadas, Bruno; Baldeiras, Inês; Ferreira, Cláudia; Teixeira, Anabela Claro; Mendes, Vera M.; et al. "Posttranslational modifications of proteins are key features in the identification of CSF biomarkers of multiple sclerosis". Journal of Neuroinflammation 19 1 (2022): http://dx.doi.org/10.1186/s12974-022-02404-2.
    10.1186/s12974-022-02404-2
  5. Inês Serrenho; Miguel Rosado; Alexandra Dinis; Carla M. Cardoso; Mário Grãos; Bruno Manadas; Graça Baltazar. "Stem Cell Therapy for Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review of Preclinical Studies". International Journal of Molecular Sciences 22 6 (2021): 3142-3142. https://doi.org/10.3390/ijms22063142.
    10.3390/ijms22063142
  6. Estronca L; Francisco V; Pitrez P; Honório I; Carvalho L; Vazão H; Blersch J; et al. "Induced pluripotent stem cell-derived vascular networks to screen nano-bio interactions.". Nanoscale horizons (2021): http://europepmc.org/abstract/med/33576750.
    10.1039/d0nh00550a
  7. Floriddia, Elisa M.; Lourenço, Tânia; Zhang, Shupei; van Bruggen, David; Hilscher, Markus M.; Kukanja, Petra; Gonçalves dos Santos, João P.; et al. "Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-19453-x.
    10.1038/s41467-020-19453-x
  8. Domingues, Catarina; Geraldo, A. Margarida; Anjo, Sandra Isabel; Matos, André; Almeida, Cláudio; Caramelo, Inês; Lopes-da-Silva, José A.; et al. "Cofilin-1 Is a Mechanosensitive Regulator of Transcription". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.00678.
    10.3389/fcell.2020.00678
  9. Anjo, Sandra I.; dos Santos, Patrícia Valério; Rosado, Luiza; Baltazar, Graça; Baldeiras, Inês; Pires, Diana; Gomes, Andreia; et al. "A different vision of translational research in biomarker discovery: a pilot study on circulatory mitochondrial proteins as Parkinson’s disease potential biomarkers". Translational Neurodegeneration 9 1 (2020): http://dx.doi.org/10.1186/s40035-020-00188-0.
    10.1186/s40035-020-00188-0
  10. Anjo, Sandra Isabel; Simões, Isaura; Castanheira, Pedro; Grãos, Mário; Manadas, Bruno. "Use of recombinant proteins as a simple and robust normalization method for untargeted proteomics screening: exhaustive performance assessment". Talanta 205 (2019): 120163. http://dx.doi.org/10.1016/j.talanta.2019.120163.
    10.1016/j.talanta.2019.120163
  11. Gerardo H; Lima A; Carvalho J; Ramos JRD; Couceiro S; Travasso RDM; Pires das Neves R; Grãos M. "Soft culture substrates favor stem-like cellular phenotype and facilitate reprogramming of human mesenchymal stem/stromal cells (hMSCs) through mechanotransduction.". Scientific reports (2019): http://europepmc.org/abstract/med/31235788.
    10.1038/s41598-019-45352-3
  12. Sandra I. Anjo; Matilde N. Melo; Liliana R. Loureiro; Lúcia Sabala; Pedro Castanheira; Mário Grãos; Bruno Manadas. "oxSWATH: An integrative method for a comprehensive redox-centered analysis combined with a generic differential proteomics screening". Redox Biology (2019): 101130-101130. https://doi.org/10.1016/j.redox.2019.101130.
    10.1016/j.redox.2019.101130
  13. Lourenço, T.; Paes De Faria, J.; Bippes, C.A.; Maia, J.; Lopes-Da-Silva, J.A.; Relvas, J.B.; Graõs, M.. "Modulation of oligodendrocyte differentiation and maturation by combined biochemical and mechanical cues". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84958568082&partnerID=MN8TOARS.
    10.1038/srep21563
  14. Lourenço, T.; Grãos, M.. "Modulation of oligodendrocyte differentiation by mechanotransduction". Frontiers in Cellular Neuroscience 10 NOV2016 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85007417961&partnerID=MN8TOARS.
    10.3389/fncel.2016.00277
  15. Kostic, I.; Fidalgo-Carvalho, I.; Aday, S.; Vazão, H.; Carvalheiro, T.; Grãos, M.; Duarte, A.; et al. "Lysophosphatidic acid enhances survival of human CD34+ cells in ischemic conditions". Scientific Reports 5 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84946935547&partnerID=MN8TOARS.
    Publicado • 10.1038/srep16406
  16. Leite, C.; Silva, N.T.; Mendes, S.; Ribeiro, A.; De Faria, J.P.; Lourenço, T.; Santos, F.D.; et al. "Differentiation of human umbilical cord matrix mesenchymal stem cells into neural-like progenitor cells and maturation into an oligodendroglial-like lineage". PLoS ONE 9 10 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84910047126&partnerID=MN8TOARS.
    10.1371/journal.pone.0111059
  17. Videira, R.; Castanheira, P.; Grãos, M.; Resende, R.; Salgueiro, L.; Faro, C.; Cavaleiro, C.. "Dose-dependent inhibition of BACE-1 by the monoterpenoid 2,3,4,4-tetramethyl-5-methylenecyclopent-2-enone in cellular and mouse models of Alzheimer's disease". Journal of Natural Products 77 6 (2014): 1275-1279. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903648214&partnerID=MN8TOARS.
    10.1021/np400903w
  18. Pereira, S.L.; Grãos, M.; Rodrigues, A.S.; Anjo, S.I.; Carvalho, R.A.; Oliveira, P.J.; Arenas, E.; Ramalho-Santos, J.. "Inhibition of mitochondrial complex III blocks neuronal differentiation and maintains embryonic stem cell pluripotency". PLoS ONE 8 12 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84891590984&partnerID=MN8TOARS.
    10.1371/journal.pone.0082095
  19. Videira, R.; Castanheira, P.; Grãos, M.; Salgueiro, L.; Faro, C.; Cavaleiro, C.. "A necrodane monoterpenoid from Lavandula luisieri essential oil as a cell-permeable inhibitor of BACE-1, the ß-secretase in Alzheimer's disease". Flavour and Fragrance Journal 28 6 (2013): 380-388. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885865286&partnerID=MN8TOARS.
    10.1002/ffj.3156
  20. Ribeiro, A.; Laranjeira, P.; Mendes, S.; Velada, I.; Leite, C.; Andrade, P.; Santos, F.; et al. "Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, natural killer and T cells". Stem Cell Research and Therapy 4 5 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84885350762&partnerID=MN8TOARS.
    10.1186/scrt336
  21. Gomes, J.R.; Costa, J.T.; Melo, C.V.; Felizzi, F.; Monteiro, P.; Pinto, M.J.; Inácio, A.R.; et al. "Excitotoxicity downregulates TrkB.FL signaling and upregulates the neuroprotective truncated TrkB receptors in cultured hippocampal and striatal neurons". Journal of Neuroscience 32 13 (2012): 4610-4622. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859013000&partnerID=MN8TOARS.
    10.1523/JNEUROSCI.0374-12.2012
  22. Maia, J.; Vazão, H.; Pedroso, D.C.S.; Jesus, C.S.H.; Brito, R.M.M.; Grãos, M.; Gil, M.H.; Ferreira, L.. "VEGF-functionalized dextran has longer intracellular bioactivity than VEGF in endothelial cells". Biomacromolecules 13 9 (2012): 2906-2916. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866111153&partnerID=MN8TOARS.
    10.1021/bm3009268
  23. Ribeiro, C.A.; Fraga, J.S.; Grãos, M.; Neves, N.M.; Reis, R.L.; Gimble, J.M.; Sousa, N.; Salgado, A.J.. "The secretome of stem cells isolated from the adipose tissue and Wharton jelly acts differently on central nervous system derived cell populations". Stem Cell Research and Therapy 3 3 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84861667226&partnerID=MN8TOARS.
    10.1186/scrt109
  24. Lourenço AS; Baldeiras I; Grãos M; Duarte CB; Lourenço, A.S.T.; Baldeiras, I.; Grãos, M.; Duarte, C.B.. "Proteomics-based technologies in the discovery of biomarkers for multiple sclerosis in the cerebrospinal fluid.". Current molecular medicine 11 4 (2011): 326-349. http://europepmc.org/abstract/med/21506919.
    10.2174/156652411795677981
  25. Vazão, H.; das Neves, R.P.; Grãos, M.; Ferreira, L.. "Towards the maturation and characterization of smooth muscle cells derived from human embryonic stem cells". PLoS ONE 6 3 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79952523704&partnerID=MN8TOARS.
    10.1371/journal.pone.0017771
  26. Grãos, M.; Simões-Wüst, A.P.; Duarte, C.B.; Brenneisen, R.; Hamburger, M.; Mennet, M.; Ramos, M.H.; et al. "Juice of Bryophyllum pinnatum (Lam.) inhibits oxytocin-induced increase of the intracellular calcium concentration in human myometrial cells". Phytomedicine 17 12 (2010): 980-986. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956619629&partnerID=MN8TOARS.
    10.1016/j.phymed.2010.03.005
  27. Grãos, M.; Gonçalves, J.P.; Valente, A.X.C.N.. "POLAR MAPPER: A computational tool for integrated visualization of protein interaction networks and mRNA expression data". Journal of the Royal Society Interface 6 39 (2009): 881-896. http://www.scopus.com/inward/record.url?eid=2-s2.0-69949092735&partnerID=MN8TOARS.
    10.1098/rsif.2008.0407
  28. Almeida, R.D.; Manadas, B.J.; Melo, C.V.; Gomes, J.R.; Mendes, C.S.; Grãos, M.M.; Carvalho, R.F.; Carvalho, A.P.; Duarte, C.B.. "Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways". Cell Death and Differentiation 12 10 (2005): 1329-1343. http://www.scopus.com/inward/record.url?eid=2-s2.0-27144508812&partnerID=MN8TOARS.
    10.1038/sj.cdd.4401662
  29. Grãos, M.; Almeida, A.D.; Chatterjee, S.. "Growth-factor-dependent phosphorylation of Bim in mitosis". Biochemical Journal 388 1 (2005): 185-194. http://www.scopus.com/inward/record.url?eid=2-s2.0-19544385223&partnerID=MN8TOARS.
    10.1042/BJ20041385
Capítulo de livro
  1. Gomes, João R.; Lobo, Andrea; Duarte, Carlos B.; Grãos, Mário. "BDNF-Induced Intracellular Signaling". In Neuromethods. Humana Press, 2017.
    10.1007/7657_2017_6
  2. Lopes, A.; Grãos, M.; Paiva, A.. "Isolation and characterization of mesenchymal stem cells from amniotic membrane". In Scientific Reports. 2015.
    10.1007/978-94-017-9975-1_12
  3. Vazão, H.; Grãos, M.; Ferreira, L.. "Vascular differentiation of human pluripotent stem cells". In Scientific Reports. 2012.
    10.1007/978-1-61779-940-2_7
Poster em conferência
  1. Santos, Gisela; Lourenço, Tânia; Grãos, Mário. "Mechanisms of mechano-modulation on oligodendrocytes differentiation". Trabalho apresentado em Advanced therapies in Neurodegeneration: Bridging Neuroscience, Bioengineering and Optogenetics. Lisbon, Portugal, April 29-30, 2020, 2020.
  2. Domingues, Catarina; Geraldo, Margarida; Anjo, Sandra I.; Manadas, Bruno; Grãos, Mário. "Mechanomodulation of the mesenchymal stem cell secretome: evaluation as a new therapeutic tool". Trabalho apresentado em Symposium on Advanced Therapies in Neurodegeneration. Bridging neuroscience, bioengineering and optogenetics, Champalimaund centre for the unknown, Lisbon, Portugal (Webinar), April 29 - 30, 2020.
  3. Santos, Gisela; Lourenço, Tânia; Grãos, Mário. "Mechano-modulation of events regulating oligodendrocyte differentiation". Trabalho apresentado em CIBB meeting 2019, 19-20th December 2019, Unidade Central, Polo III, University of Coimbra, Portugal, 2019.
  4. Domingues, Catarina; Geraldo, Margarida; Matos, André; Almeida, Cláudio; Anjo, Sandra I.; Manadas, Bruno; Pires-das-Neves, Ricardo; Grãos, Mário. "Identification and characterization of Cofilin-1 in the proteome of mesenchymal stem cells". Trabalho apresentado em BEBday2019, University of Coimbra, 9-10th December 2019, Coimbra, Portugal, 2019.
  5. Lourenço, Tânia; Falcão, Ana Mendanha; Castelo-Branco, Gonçalo; Grãos, Mário. "Epigenetic changes in oligodendrocytes enhanced by mechanotransduction". Trabalho apresentado em XIV European Meeting on Glial Cells in Health and Disease, 10-13th July 2019, Porto, Portugal, 2019.
  6. Domingues, Catarina; Geraldo, Margarida; Anjo, Sandra I.; Manadas, Bruno; Grãos, Mário. "The influence of mechanical cues on the secretome of mesenchymal stem cells". Trabalho apresentado em Secretome without borders, December 6, 2018, University of Minho, Braga, Portugal, 2018.
  7. Lourenço, Tânia; Falcão, Ana Mendanha; Castelo-Branco, Gonçalo; Grãos, Mário. "Epigenetic changes in oligodendrocytes enhanced by mechanotransduction". Trabalho apresentado em Epigenetics in the nervous system: development and disease, Karolinska Institutet, Stockholm, Sweden, 1 - 3 October, 2018.
  8. Lourenço, Tânia; Paes De Faria, Joana; Maia, João; Lopes-da-Silva, José A.; Bettencourt Relvas, João; Grãos, Mário. "Enhancement of the differentiation and maturation of oligodendrocyte progenitor cell by mechanical cues". Trabalho apresentado em 18th meeting of the Portuguese Biochemistry Society, Coimbra, 17-20th December, 2014.
  9. Sandra I. Anjo; Matilde Melo; Liliana Loureiro; Lúcia Sabala; José Carvalho; Vera M. Mendes; Tiago Faria; et al. "DJ-1 Neuronal Rescue Under Oxidative Stress: Implications For Parkinson¿s Disease (Best poster award in Neuroscience and Disease)". Trabalho apresentado em XI CNC Annual Meeting, 18th and 19th December 2013, Cantanhede, Portugal, 2013.
  10. S.L. Prereira; Grãos, Mário; Sandra I. Anjo; T. Perestrelo; M. Correia; P. J. Oliveira; R. A. Carvalho; E. Arenas; J. Ramalho-Santos. "Metabolic Regulation of Midbrain Dopaminergic Neurons Differentiation". Trabalho apresentado em International Conference on Stem Cells for Drug Screening and Regenerative Medicine; Cantanhede, 19 July, 2013.
  11. Lourenço, Tânia; Maia, João; Lopes-da-Silva, José A.; Grãos, Mário. "Hydrogel-based platforms for oligodendrocyte progenitors maintenance and differentiation". Trabalho apresentado em 1st research Coimbra in Health sciences, Coimbra, Portugal, April, 2013.
  12. Grãos, Mário; Lourenço, Tânia; Maia, João; Lopes-da-Silva, José A.. "Hydrogel-based platforms for oligodendrocyte progenitors maintenance and differentiation". Trabalho apresentado em Exciting Biologies - Forces in Biology, 4th-6th October, Dublin, Ireland, 2012.
  13. Leite, Cristiana; Mendes, Sandrine; dos Santos, Francisco; Paiva, Artur; da Silva, Cláudia Lobato; Grãos, Mário. "Differentiation of mesenchymal stem cells into neural progenitor-like cells and subsequent maturation into oligodendroglial-like lineages". Trabalho apresentado em 6th International Meeting of the Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC), 28th, 29th April, Cantanhede, Portugal, 2011.
  14. I. Velada; S. Mendes; A.P. Amaral; A. Ribeiro; A.S. Gonçalves; Grãos, Mário; C. Cardoso; et al. "Umbilical cord Matrix Mesenchymal Stem Cells exhibit a lower ability to inhibit T cell activation, proliferation, differentiation to Th1 subtype and to induce regulatory T cells". Trabalho apresentado em 6th International Meeting of the Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC), 28th, 29th April, Cantanhede, Portugal, 2011.
  15. João Maia; Helena Vazão; Dora C.S. Pedroso; Catarina de Jesus; Rui M.M. Brito; Grãos, Mário; M. Helena Gil; Lino Ferreira. "Dual pro-angiogenic therapy based on the release of VEGF and endothelial cells derived from umbilical cord stem cells in a hybrid network". Trabalho apresentado em 6th International Meeting of the Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC), 28th, 29th April, Cantanhede, Portugal, 2011.
  16. Simões-Wüst, AP; Grãos, Mário; Duarte, CB; Brenneisen, R.; Hamburger, M.; Mennet, M.; Schnelle, M.; et al. "Potential of a combined tocolysis with Bryophyllum pinnatum (Lam.) and nifedipine". Trabalho apresentado em 3rd European Congress for Integrative Medicine. December 3-4, Berlin, 2010.
  17. Bruno Manadas; Vera M. Mendes; Ana S. T. Lourenço; Inês Baldeiras; Sónia Batista; Grãos, Mário; Lívia Sousa; et al. "Finding potential biomarkers of Multiple Sclerosis". Trabalho apresentado em 4th EUPA meeting, 23rd-27th October, Estoril, Portugal, 2010.
  18. J.T. Costa; J.R. Gomes; P. Monteiro; C.V. Melo; Grãos, Mário; C.B. Duarte. "Excitotoxic damage downregulates TrkB signaling activity and upregulates the truncated form of TrkB in cultured hippocampal and striatal neurons". Trabalho apresentado em 7th FENS 2010 (Forum of European Neurosciences). 3-7 July. Amsterdam, Holland, 2010.
  19. Vera M. Mendes; Ana Lourenço; Bruno Manadas; Inês Baldeiras; Sónia Batista; Grãos, Mário; Lívia Diogo Sousa; et al. "Finding potential biomarkers of Multiple Sclerosis by a label-free LC-MS approach". Trabalho apresentado em 58th ASMS Conference, May 23rd - 27th, Salt Lake City, USA, 2010.
  20. Vazão, H.; Pires-das-Neves, Ricardo; Grãos, Mário; Ferreira, L.. "Towards the characterization and maturation of smooth muscle cells derived from human embryonic stem cells". Trabalho apresentado em Hydra VI European Summer school – Stem cells & regenerative Medicine. September, Hydra, Grece, 2010.
  21. Simões-Wüst, AP; Grãos, Mário; Duarte, CB; Brenneisen, R.; Hamburger, M.; Mennet, M.; Ramos, F.M.H.; et al. "Press Juice of Bryophyllum pinnatum (Lam.) Inhibits Oxytocin-Induced Increase of the Intracellular Calcium Concentration in Human Myometrial Cells". Trabalho apresentado em Swiss Pharma 2009, University of Bern, Switzerland., 2009.
  22. Vera M. Mendes; Ana S. T. Lourenço; Bruno Manadas; Inês Baldeiras; Sónia Batista; Grãos, Mário; Lívia Diogo Sousa; et al. "Label free quantification of low molecular weight biomolecules by LC-MS for biomarker discovery in multiple sclerosis". Trabalho apresentado em 5th Congress of the Portuguese Proteomics Network – ProCura, and 1st International Congress on Analytical Proteomics – ICAP, Costa da Caparica, Portugal, 2009.
  23. Ana S. T. Lourenço; Vera M. Mendes; Bruno Manadas; Inês Baldeiras; Sónia Batista; Grãos, Mário; Lívia Diogo Sousa; et al. "Identification of biomarkers for Multiple Sclerosis using a proteomic approach". Trabalho apresentado em 5th Congress of the Portuguese Proteomics Network – ProCura, and 1st International Congress on Analytical Proteomics – ICAP, Costa da Caparica, Portugal, 2009.
  24. C.B. Duarte; J.T. Costa; Grãos, Mário; C.V. Melo; J.R. Gomes. "Excitotoxic damage downregulates TrkB signaling activity and upregulates the truncated form of TrkB in cultured hippocampal and striatal neurons". Trabalho apresentado em Society for Neuroscience 38th Annual Meeting. 15 – 19 Novembre. Washington DC, USA, 2008.
  25. Grãos, Mário; Joana P. Gonçalves; André X. C. N. Valente. "Polar Mapper: software tool for integrated visualization of protein interaction networks and mRNA expression data". Trabalho apresentado em The 9th International Conference on Systems Biology (ICSB 2008), Gotemburg, Sweden, 2008.
  26. Grãos, Mário; Joana P. Gonçalves; André X. C. N. Valente. "Polar Mapper: software tool for integrated visualization of protein interaction networks and mRNA expression data". Trabalho apresentado em First Portuguese Forum on Computational Biology FPBC-2008, Oeiras, Portugal, 2008.
  27. Veloso, A.; Grãos, Mário; Chatterjee, S.. "Role of the pro-apoptotic protein Bim in determining cell fate during cell cycle". Trabalho apresentado em The ELSO meeting, Nice, France, 2004.
  28. Grãos, Mário; Chatterjee, S.. "Cell-cycle mediated regulation of Bim". Trabalho apresentado em The ELSO meeting, Dresden, Germany, 2003.
  29. César M. Mendes; Grãos, Mário; Arsélio P. Carvalho; Carlos B. Duarte. "Brain derived neurotrophic factor (BDNF) protects hippocampal neurons against glutamate-induced apoptotic cell death". Trabalho apresentado em 12th National Congress of Biochemistry, Póvoa de Varzim, Portugal, 2000.
  30. Carlos B. Duarte; César M. Mendes; Grãos, Mário; Arsélio P. Carvalho. "Protective role of neurotrophins against glutamate toxicity in cultured hippocampal neurons: Signalling mechanisms". Trabalho apresentado em 30th Meeting of the Society for Neuroscience, New Orleans, USA, 2000.
  31. César M. Mendes; Grãos, Mário; Arsélio P. Carvalho; Carlos B. Duarte. "Neurotrophins protect hippocampal neurons against glutamate toxicity through the phosphatidylinositol 3-kinase (PI3-K) and mitogen activated protein kinase (MAPK) pathway". Trabalho apresentado em 3rd Symposium of the International Cell Death Society, El Escorial, Spain, 2000.
Recurso online
  1. Anjo SI; Simões I; Castanheira P; Grãos M; Manadas B. A generic normalization method for proper quantification in untargeted proteomics screening. 2018. http://europepmc.org/abstract/PPR/PPR13974.
    10.1101/307504
Tese / Dissertação
  1. Grãos, Mário. "Regulation of pro-apoptotic protein Bim in cell cycle and stress". Doutoramento, Instituto Gulbenkian de Ciência, 2006. https://renates2.dgeec.mec.pt/ppsqdet.asp.
  2. Grãos, Mário. "Protective Effects of Neurotrophins Against Excitotoxic Cell Death in the Hippocampus: Role of Different Signalling Pathways". Licenciatura, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 1999.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2019 Mechanomodulation of human stem cells: a crosstalk between cytoskeleton and nucleus Heloísa Gerardo, Catarina Domingues, Ana Lima, Margarida Geraldo, João Carvalho, Sandra I. Anjo, João R. D. Ramos, Sofia Couceiro, Rui D. M. Travasso, Bruno Manadas, Ricardo Pires das Neves & Mário Grãos EuroCellNet COST Action Workshop on Mechanobiology in Migrating Cells, Coimbra, Portugal
2016 Mechanotransduction and oligodendrocyte biology Symposium of the Portuguese Glial Network, Braga, Portugal
2016 Platforms for cell culture and mechanomodulation studies II Biotechnology Meeting, ESAC, Coimbra, Portugal
2015 Modulation of cell stemness and differentiation by biochemical and mechanical factors CNC.IBILI fall series seminars, Coimbra, Portugal
2014 Modulation of cell stemness and differentiation by biochemical and mechanical factors CNC.IBILI fall series seminars, Cantanhede, Portugal
2014 Cultura de Células Animais Ciclo de Palestras em Biotecnologia, Escola Superior Agrária de Coimbra (ESAC), Instituto Politécnico de Coimbra, Coimbra, Portugal
2013 Role of mechanotransduction in oligodendrocyte progenitor maintenance and differentiation 20 Years’ Celebration of the Fundação Calouste Gulbenkian/Instituto Gulbenkian de Ciência PhD Programmes, Curia, Portugal
2013 Hydrogel-based platform for oligodendrocyte progenitor maintenance and differentiation 4th Berlin-Brandenburg School for Regenerative Therapies PhD Symposium, Berlin 4-6 th December 2013
2012 Differentiation of mesenchymal stem cells into neural progenitor-like cells and subsequent maturation into oligodendroglial-like lineages 7th International Meeting of the Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC), 26th-27th April, Porto, Portugal.
2012 Dextran functionalized with VEGF has longer intracellular bioactivity than VEGF in endothelial cells 7th International Meeting of the Portuguese Society for Stem Cells and Cell Therapy (SPCE-TC), 26th-27th April, Porto, Portugal.
2011/12 Towards the characterization and maturation of smooth muscle cells derived from human embryonic stem cells Annual Centre of Neurosciences and Cell Biology Meeting. Coimbra, Portugal
(Portugal)
2011/09 Towards the characterization and maturation of smooth muscle cells derived from human embryonic stem cells 24th European Conference on Biomaterilas. Dublin, Ireland
(Irlanda)
2011 Mesenchymal stem cells and cellular therapy XI Meeting for Clinical Analysis and Public Health, Escola Superior de Tecnologia da Saúde de Coimbra, Coimbra, Portugal
2003 Cell-cycle mediated regulation of Bim Seminar at the Instituto Gulbenkian de Ciência, Oeiras, Portugal
Instituto Gulbenkian de Ciência, Oeiras, Portugal (Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021/01 - Atual A different perspective in translational research: from secretome to peripheral biomarkers of hypoxic-ischemic Encephalopathy
Coorientador de Miguel Maria Varandas Anão Rosado
 PhD Programme in Experimental Biology and Biomedicine (PDBEB) (Doutoramento)
Universidade de Coimbra, Portugal
2020/09 - Atual The Role of Sp1 in Oligodendrocyte Differentiation: a mechanically regulated transcription factor
Coorientador
 Master in Biomedical Research (Mestrado)
Universidade de Coimbra, Portugal
2020/01/01 - Atual Mechanotransduction meets autophagy: implications and opportunities in Alzheimer’s disease
Orientador
 Pharmaceutical Sciences (Doutoramento)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2020/01 - Atual New approaches on Hypoxic-Ischemic Encephalopathy: translational research to diagnose and monitor stem cell therapy
Coorientador
 PhD Programme in Experimental Biology and Biomedicine (PDBEB) (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017/05/01 - Atual Role of SP1 and PADI2 during oligodendrocyte differentiation enhanced by mechanotransduction
Orientador
 PhD Programme in Experimental Biology and Biomedicine (PDBEB) (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2017/02 - Atual Mechanomodulation of the mesenchymal stem cell proteome: elucidation of mechanisms and evaluation as a therapeutic opportunity
Orientador
 PhD Programme in Experimental Biology and Biomedicine (PDBEB) (Doutoramento)
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2019/05 - 2019/11 Determination of the transcription rate in human cells cultured on substrates with distinct degrees of stiffness
Orientador
 Licenciatura em Biotecnologia (Licenciatura/Bacharelato)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2019/05 - 2019/11 Determination of the transcription rate in human cells subjected to stimuli that modulate intracellular contractility
Orientador
 Licenciatura em Biotecnologia (Licenciatura/Bacharelato)
Instituto Politécnico de Coimbra Escola Superior Agrária de Coimbra, Portugal
2017/09 - 2018/12 Influência de isoformas de Laminina na mecanobiologia de oligodendrócitos
Orientador
 Program in Molecular and Cellular Biology (Mestrado)
Universidade de Aveiro Departamento de Biologia, Portugal
2016/09 - 2017/09 Mechanomodulation of chondrogenic differentiation of mesenchymal stem cells
Orientador
 Program in Biochemistry (Mestrado)
Universidade de Aveiro Departamento de Química, Portugal
2014/09 - 2015/12 Influence of substrates composition on immunomodulation by MSCs
Orientador
 Program in Molecular Biomedicine (Mestrado)
Universidade de Aveiro, Portugal
2014/09 - 2015/12 Substrates effect on Mesenchymal Stem Cells (MSCs) secretome and cellular subproteome
Orientador
 Program in Cell and Molecular Biology (Mestrado)
Universidade de Aveiro Departamento de Biologia, Portugal
2013/09 - 2014/09 Induction of pluripotency modulated by substrate rigidity
Orientador
 Master in Cellular and Molecular Biology (Mestrado)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2012/10 - 2013/12 Production, characterization and functionalization of hydrogels for in vitro cell culture
Orientador
 Program in Molecular Biotechnology (Mestrado)
Universidade de Aveiro Departamento de Química, Portugal
2012/10 - 2013/10 Characterization of human umbilical cord matrix mesenchymal stem cells isolated and cultured on tunable hydrogel-based platforms
Orientador
 Master in Cellular and Molecular Biology (Mestrado)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2011/06 - 2012/08 Regulation of extracellular matrix mimetics on oligodendrocyte differentiation in vitro
Orientador
 Master in Cellular and Molecular Biology (Mestrado)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal
2010/06 - 2011/08 Differentiation of mesenchymal stem cells into neural progenitor-like cells and subsequent maturation into oligodendroglial-like lineages
Orientador
 Master in Cellular and Molecular Biology (Mestrado)
Universidade de Coimbra Departamento de Ciências da Vida, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2019/12 - Atual Invited Guest Editor to organize upcoming Research Topic related with Mechanobiology with 'Frontiers in Cellular Neuroscience' (2021)
Outro (Coorganizador)
2020/01/08 - 2020/01/08 Organizer of seminar within the CNC/CIBB seminar series, ‘Multiple sclerosis: current pathological and clinical concepts.’, Sónia Batista (Coimbra University Hospital Center and Faculty of Medicine of the University of Coimbra), Cantanhede, 8th January 2020. (2020/01/08 - 2020/01/08)
Seminário (Coorganizador)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020 - 2020 Hosting of in-site visit by students from the Master in Pharmaceutic Biotechnology from the Faculty of Pharmacy of the University of Coimbra to the Mechanobiology Laboratory, CNC at UC-Biotech, Cantanhede, Portugal. (2020 - 2020)
Outro (Coorganizador)
2019/01/23 - 2019/01/23 Organizer of seminar within the CNC seminar series, ‘Mechanisms of nuclear positioning during cell migration and muscle development.’, Edgar Gomes (Institute of Molecular Medicine, University of Lisbon), Cantanhede, 23rd January 2019. (2019/01/23 - 2019/01/23)
Seminário (Coorganizador)
 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2018 - 2018 Host lab for the Scientific Training Program for high school students organized by IEC (Instituto de Educação e Cidadania), UC Biotech, Cantanhede, December 17th-19th (2018 - 2018)
2017 - 2017 Host lab for training (coordinated by ‘Centro de Ciência Júnior’, at Biocant) of Portuguese students preparing for the International Ibero-American Olimpics in Biology (Azores, Portugal), who were awarded with 2 gold and 1 bronze medals and 1 merit award at the competition. (2017 - 2017)
2017 - 2017 Host lab for training (coordinated by ‘Centro de Ciência Júnior’, at Biocant) of Portuguese students preparing for the International Biology Olympics, at the UK, who were awarded with 2 bronze medals at the competition. (2017 - 2017)
2016 - 2016 Host lab for training (coordinated by ‘Centro de Ciência Júnior’, at Biocant) of Portuguese students preparing for the International Biology Olympics, in Vietnam, who were awarded with 1 bronze medal and 1 merit award at the competition. (2016 - 2016)
2015 - 2015 Host lab for training (coordinated by ‘Centro de Ciência Júnior’, at Biocant) of Portuguese students preparing for the International Ibero-American Olimpics in Biology (El Salvador), who were awarded with 2 bronze medals and 2 merit awards at the competition. (2015 - 2015)
2015 - 2015 Host lab for training (coordinated by ‘Centro de Ciência Júnior’, at Biocant) of Portuguese students preparing for the International Biology Olympics, in Denmark, who were awarded with 1 bronze medal and 1 merit award at the competition. (2015 - 2015)
2014 - 2014 Host lab for training (coordinate by ‘Centro de Ciência Júnior’, at Biocant) of Portuguese students preparing for the 2014 International Biology Olympics, in Bali, who were awarded with 2 bronze medals at the competition. (2014 - 2014)
2011 - 2011 Co-organizer and Scientific Advisor of the Sharebiotech Cell/Tissue Culture Workshop, 15th November 2011, Biocant, Cantanhede, Portugal (2011/11/15 - 2011/11/15)
Oficina (workshop)
 Biocant Associação de Transferência de Tecnologia, Portugal
2011 - 2011 Co-organizer, 6th Annual International Meeting of the Portuguese Society for Stem Cells and Cellular Therapies, April 2011, Portugal. (2011/04 - 2011/04)
Encontro
2008 - 2011 Co-organization and teaching of the MIT-Portugal Program Introductory Course in Molecular and Cell Biology: ‘Chemistry of the cell’, ‘Cell cycle’ and ‘Cell death’. (2008 - 2011)
Outro (Coorganizador)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2020/07/22 - 2020/07/22 Outreach Activity - Public conference about Stem Cells broadcasted through YouTube, organized by IEC - Instituto de Educação e Cidadania (https://www.youtube.com/watch?v=2zi_5kOa9d4)
Conferência
2019/11/06 - 2019/11/08 Attended the "Course Atomic Force Microscopy applied to Life Sciences", 2nd edition
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019 - 2019 Outreach activity - Talk for high school students (11th and 12th grade) and teachers, organized by IEC (Instituto de Educação e Cidadania) entitled ‘Stem Cells: what are they and what are they good for?’, Escola Secundária Marques de Castilho, Águeda, Portugal.
Seminário
2019 - 2019 Outreach activity - Talk for Senior citizens about Brain and Healthy Ageing (under the framework of the Brain Awareness Week) at the Senior Academy of Seia, Seia, Portugal.
Seminário
2019 - 2019 Outreach activity - Advanced courses for highschool students and teachers ‘Cell cycle and apoptosis’, within the Cell Signalling course, organized by the Institute for Education and Citizenship (IEC) at Escola Secundária Marues de Castilho, Águeda, Portugal.
Seminário
2019 - 2019 Outreach activity - Advanced courses for highschool students and teachers ‘Cell cycle and apoptosis’, within the Cell Signalling course, organized by the Institute for Education and Citizenship (IEC) at EBS Anadia, Anadia, Portugal.
Seminário
2017 - 2019 ‘Keep the bugs away — Good Practices in culture rooms for the protection of users and common goods’, CNC welcome day, CNC, University of Coimbra, Coimbra, Portugal
Seminário
2018 - 2018 Outreach activity - Advanced courses for highschool students and teachers ‘Cell cycle and apoptosis’, within the Cell Signalling course, organized by the Institute for Education and Citizenship (IEC), at ES Adolfo Portela, Águeda, Portugal
Seminário
2015 - 2018 Outreach activity - Advanced course for highschool students and teachers ‘Cell cycle and apoptosis’, within the Cell Signalling course, organized by the Institute for Education and Citizenship (IEC), Mamarrosa, Oliveira do Bairro, Portugal
Seminário
2017 - 2017 Outreach activity - Talk for for highschool students and teachers ‘Cell Biology and in vitro animal cell culture’, organized by ‘Centro de Ciência Júnior’ at Biocant, Cantanhede, Portugal
Seminário
2017 - 2017 Outreach activity - Advanced courses for highschool students and teachers ‘Cell cycle and apoptosis’, within the Cell Signalling course, organized by the Institute for Education and Citizenship (IEC) at ES Marques de Castilho, Águeda, Portugal.
Seminário
2016 - 2016 Outreach activity - Talk for highschool students and teachers ‘Potential of stem cells — in vivo functions and their differentiation’, Institute for Education and Citizenship (IEC), Mamarrosa, Oliveira do Bairro, Portugal
Seminário
2016 - 2016 Outreach activity - Advanced courses for highschool students and teachers ‘Cell cycle and apoptosis’, within the Cell Signalling course, organized by the Institute for Education and Citizenship (IEC), at ES Adolfo Portela, Águeda, Portugal
Seminário
2016 - 2016 Outreach activity - Advanced courses for highschool students and teachers ‘Potential of stem cells — in vivo functions and their differentiation’, Institute for Education and Citizenship (IEC), Mamarrosa, Oliveira do Bairro, Portugal
Seminário
2015 - 2015 Outreach activity - Talk for highschool students and teachers ‘Potential of stem cells — in vivo functions and their differentiation’, Institute for Education and Citizenship (IEC), Mamarrosa, Oliveira do Bairro, Portugal
Seminário
2013 - 2013 Certificate by the Portuguese Scientific-Pedagogic Council for Continuous Training as Instructor in Biology (Area A07) – Certificate CCPFC/RFO-32625/13.
Conselho Científico-Pedagógico da Formação Contínua, Portugal
2013 - 2013 Outreach activity – Sessions for highschool students, ‘Mechanotransduction and Cell Differentiation’, Centro de Ciência Júnior, BiocantPark, Cantanhede, Portugal
Seminário
2012 - 2012 Animal welfare certificate as coordinating researcher for animal experimentation by the Portuguese General-Administration of Veterinary Affairs (DGAV)
Direcção-Geral de Alimentação e Veterinária, Portugal
2012 - 2012 Outreach activity - Talk for the general public ‘Stem Cells: what are they and what are they good for?’, Institute for Education and Citizenship (IEC), Mamarrosa, Oliveira do Bairro, Portugal
Seminário
2012 - 2012 Invited lecture (by student’s association) for undergraduate students at the University of Aveiro, ‘Células Estaminais Mesenquimais da Matriz do Cordão Umbilical’, Univerity of Aveiro, Aveiro, Portugal
Seminário
2012 - 2012 Outreach Activity - Advanced courses for highschool students and teachers ‘Mechanotransduction and differentiation of stem cells’, Institute for Education and Citizenship (IEC), Mamarrosa, Oliveira do Bairro, Portugal
Seminário
2010 - 2010 Outreach Activity - Presentation for highschool students (‘Projeto Escola’) on the topic ‘Stem cells’, Escola Secundária de Cantanhede, Cantanhede, Portugal
Seminário

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2021/02 The extracellular role of DJ-1 in the regulation of signaling pathways - implications for Parkinson s Disease
Arguente principal
 Margarida Seco Martins Marques Neves (Mestrado)
Universidade de Aveiro, Portugal
2021/01/05 Dissecting the mechanisms governing skin wound healing induced by an umbilical cord blood-derived product
Arguente
 Sílvia Maria do Couto Rodrigues (Doutoramento)
Universidade de Coimbra, Portugal
2019 Uncover the mechanism behind miRNA function on cell survival
Arguente principal
 Marta Barão (Mestrado)
Universidade de Coimbra, Portugal
2018 Scalable Platform for the Expansion of Human Mesenchymal Stem/Stromal Cells Under Dynamic Conditions
Arguente principal
 Francisco António Guilherme Moreira (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018 Quiet! They may be at rest - Metabolic regulation of paused pluripotency
Arguente principal
 Bibiana Correia da Silva (Mestrado)
Universidade de Coimbra, Portugal
2018 iPSCs-derived NESCs for neuroregeneration in MJD
Arguente principal
 Daniel Alexandre Sousa Henriques (Mestrado)
Universidade de Coimbra, Portugal
2017 Framing Pluripotency: From Gene to Image
Arguente
 Tânia Perestrelo (Doutoramento)
Universidade de Coimbra, Portugal
2017 Implementation of biomolecular methods to explore the mode of action of Exo-Wound in vitro
Arguente principal
 CLÁUDIA FILIPA DE OLIVEIRA GOMES (Mestrado)
Universidade de Aveiro, Portugal
2017 Unravelling the players of Mesenchymal Stromal Cells' Neuroprotective Effect in Machado-Joseph Disease
Arguente principal
 João Carlos Versos Varanda Barata (Mestrado)
Universidade de Coimbra, Portugal
2016 Effect of mesenchymal cells from umbilical cord matrix on T lymphocytes from peripheral blood, spleen and lymph node biopsies
Arguente principal
 Sofia de Jesus Gomes Duarte (Mestrado)
Universidade de Aveiro, Portugal
2015 Estudo da Actividade em BACE-1, uma Protease Aspártica Envolvida na Doença de Alzheimer
Arguente
 Rita Videira (Doutoramento)
Universidade de Coimbra, Portugal
2014 Regulation of DJ-1 Expression by Neuron-Astrocyte Interaction
Arguente principal
 Mónica Calado Sardinha (Mestrado)
Universidade da Beira Interior, Portugal
2013 Identification and validation of new potential targets for neuroprotection following experimental demyelination
Arguente principal
 Eduarda Lopes (Mestrado)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2013 Reprogramming strategies for cord blood cd34+ cells with different mitochondria phenotype
Arguente principal
 João Luís Cardoso Dias Monteiro (Mestrado)
Universidade de Coimbra, Portugal
2013 Construction of a toolbox for proteomic data visualization: finding new targets for Parkinson’s Disease
Arguente
 José Miguel Teixeira Freire de Carvalho (Mestrado)
Universidade de Coimbra, Portugal
2011 Isolation, Characterization and Ex-vivo Expansion of Mesenchymal Stem Cells from Umbilical Cord Matrix
Arguente principal
 Irina Simões (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2010 Effects of the secretome of umbilical cord stem cells in hippocampal, cerebellar and cortical neurons
Arguente
 Joana Fraga (Mestrado)
Universidade do Minho, Portugal
2007 CROSS-TALK BETWEEN MITOSIS AND APOPTOSIS THROUGH THE BCL-2 FAMILY PROTEIN BIM
Arguente
 Ana Gírio Veloso (Doutoramento)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2013 - Atual Mechanotransduction and modulation of cell fate (Master in Cellular and Molecular Biology) Cell Regulation Course (Mestrado) Universidade de Coimbra, Portugal
2007 - Atual Apoptosis (Master in Cellular and Molecular Biology) Cell Regulation Course (Mestrado) Universidade de Coimbra, Portugal
2020 - 2020 Molecular and genetic blueprint of the cell - Invited lecturer, 2nd NANOSTEM Summer School (H2020-MSCA-ITN-2017 G.A. 764958) 2nd NANOSTEM Summer School (H2020-MSCA-ITN-2017 G.A. 764958) (Outros)
2019 - 2019 Invited lecturer, presentation focusing on academic & career development in biomedical research and on my current research interests (degree in Biology, Department of Life Sciences, Faculty of Sciences and Technology, University of Coimbra, Portugal) Translational Biology and Biomedicine (Bacharelato) Universidade de Coimbra, Portugal
2019 - 2019 Mechanobiology and neurodegenerative diseases (PhD Programme in Experimental Biology and Biomedicine - PDBEB) Advanced therapies course (Doutoramento) Universidade de Coimbra, Portugal
2018 - 2018 Mechanobiology and neurodegenerative diseases (Master in Biomedical Engineering, Specialization in Biomaterials) (Mestrado integrado) Universidade de Coimbra, Portugal
2018 - 2018 Stem cells and mechanotransduction (PhD Programme in Experimental Biology and Biomedicine - PDBEB) Advanced therapies course (Doutoramento) Universidade de Coimbra, Portugal
2016 - 2016 Mechanotransduction and modulation of cell fate (PhD Programme in Experimental Biology and Biomedicine - PDBEB) Advanced Therapies Course (Doutoramento) Universidade de Coimbra, Portugal
2015 - 2015 Platforms for cell culture and mechanomodulation studies Human Cell Culture course (Outros) Instituto Politécnico de Bragança, Portugal
2015 - 2015 Mechanotransduction and modulation of cell fate (PhD Programme in Experimental Biology and Biomedicine - PDBEB) Cell and Tissue Engineering Advanced Course (Doutoramento) Universidade de Coimbra, Portugal
2011 - 2015 Animal Cell Culture (Cell Biology course, degree in Biotechnology) Degree in Biotechnology (Bacharelato) Instituto Politécnico de Coimbra, Portugal
2014 - 2014 Molecular and genetic blueprint of the cell (3rd Nanodrug Summer School) (Outros)
2012 - 2012 Mechanotransduction and Stem Cells Differentiation (PhD Programme in Experimental Biology and Biomedicine - PDBEB) Cell and Tissue Engineering Advanced Course (Doutoramento) Universidade de Coimbra, Portugal
2012 - 2012 The xMAP multiplex array system: technology, current uses and potentials Medicinal Chemistry (Bacharelato) Universidade de Coimbra, Portugal
2010 - 2012 Cell death and its regulation (PhD Program in Health Sciences) Cell Regulation and Signalling Course Universidade de Coimbra, Portugal
2008 - 2011 Chemistry of the cell (MIT-Portugal Bioengineering Systems Doctoral program) Introductory Course in Molecular and Cell Biology (Doutoramento) Universidade de Coimbra, Portugal
2008 - 2011 Cell cycle (MIT-Portugal Bioengineering Systems Doctoral program) Introductory Course in Molecular and Cell Biology (Doutoramento) Universidade de Coimbra, Portugal
2008 - 2011 Cell death (MIT-Portugal Bioengineering Systems Doctoral program) Introductory Course in Molecular and Cell Biology (Doutoramento) Universidade de Coimbra, Portugal
2009 - 2009 The xMAP multiplex array system: technology, current uses and potentials Medicinal Chemistry (Bacharelato) Universidade de Coimbra, Portugal

Membro de associação

Nome da associação Tipo de participação
2009 - Atual Member of the Portuguese Society for Stem Cells and Cellular Therapy Member
1997 - Atual Member of the Biochemistry Portuguese Society Member

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2019/03 - Atual Member of the Reviewer Board of MDPI journal 'Cells'
Membro

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2013 - 2021/03 Reviewer of at least 29 research articles for the following international specialty journals (https://publons.com/a/1321161): Advanced Science, Advanced Biosystems, Acta Biomaterialia, Biomaterials Science, Stem Cells; Stem Cell Res & Ther, Int J of Molecular Sciences, Cells, ASN Neuro, Scientific Reports, Frontiers in Cellular Neuroscience, Stem Cells International, Journal of Clinical Medicine, Tissue Engineering, Neurochemical Research, BMC Biotechnology, Experimental and Molecular Pathology, JoVE, Bioengineering
Distinções

Outra distinção

2000 PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
1999 PGDBM PhD Fellowship (Gulbenkian PhD. Program)
Fundação Calouste Gulbenkian, Portugal

Instituto Gulbenkian de Ciência, Portugal