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Dr Rawson received a BSc (Hons) degree in Biochemistry from the University of Huddersfield in 2004. As part of his degree he spent a year placement at Covance Laboratories working in the Department of Molecular Genetics and Toxicology. He subsequently returned to Covance after completion of his degree and worked within the Cytogenetics Laboratory. This then led him to study for a PhD in which he developed electrochemical biosensors for detecting toxicity from 3D organotypic liver spheroids under the supervision of Professor John Hart at the University of the West of England. He then moved to New Zealand to undertake a Post-Doctoral Fellowship at the University of Canterbury under the guidance of Prof Alison Downard within the Department of Chemistry. His research here focused on the development of conducting surfaces that could "wire" into cell membrane and cell wall redox sites. This allowed for the capture of electrons from cells and shed new light on their biological origin. This was followed by a Post Doc at the University of Birmingham within the Mendes Laboratory in the School of Chemical Engineering. Here he combined his previous skills to develop nanostructured electrodes that could electrochemically communicate with the internal environment of cells. He then moved to Nottingham within the School of Pharmacy in 2013 to take up an Independent Early Career Leverhulme Fellowship.In 2016 he was awarded a Nottingham Research Fellowship and promoted to Associate Professor in 2019. Dr Rawson's research is truly multidisciplinary spanning the chemical-biology interface. His expertise therefore spans multiple disciplines which include Electrochemistry, Cell Surface Biochemistry, Bionanotechnology, Surface Chemistry, Electroceutics, Functional Materials and Biosensors and Bioelectronics. He has been awarded with several grants worth more than £3.2M in total. Dr Rawson teaches on the Pharmacy module Medical Diagnostics (B34MED) and Masters in Bioengineering module Biomedical Applications of Biomaterials (MM4BAB) Dr Rawson has supervised 4 PhD's to completion and he is currently supervising 8 PhD students and 22 masters students.
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Identificação

Identificação pessoal

Nome completo
Frankie Rawson

Nomes de citação

  • Rawson, Frankie
  • Frankie J Rawson

Identificadores de autor

Ciência ID
191D-B4E5-F787
ORCID iD
0000-0002-4872-8928

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês (Idioma materno)
Formação
Grau Classificação
2005/10/01 - 2008/09/30
Concluído
 PhD (Postgraduate Certificate)
Especialização em Electroanalytical Chemistry
University of the West of England Bristol, Reino Unido
"The design, development and application of a novel electrochemical biosensor/sensor system for the real-time monitoring of in-vitro cell toxicity" (TESE/DISSERTAÇÃO)
 Pass
2000/09/01 - 2004/06/01
Concluído
 BSc (Hons) andBiochemistry (Bachelor)
Especialização em Biochemistry
University of Huddersfield, Reino Unido
"Characterisation of Oxalate Oxidase" (TESE/DISSERTAÇÃO)
 2:1
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2019 - Atual Professor Associado (Docente Universitário) University of Nottingham School of Pharmacy, Reino Unido
University of Nottingham School of Pharmacy, Reino Unido
Projetos

Bolsa

Designação Financiadores
2019 - 2024 High resolution, cryogenic analytical and transfer scanning electron microscope (HR-CAT-SEM)
EP/S021434/1
Investigador
University of Nottingham School of Chemistry, Reino Unido
 Engineering and Physical Sciences Research Council
Em curso
2018 - 2023 Wireless communication with cells towards bioelectronic treatments of the future
EP/R004072/1
Investigador responsável
University of Nottingham School of Pharmacy, Reino Unido
 Engineering and Physical Sciences Research Council
Em curso
2015 - 2023 Nottingham-Rothamsted Doctoral Training Partnership
BB/M008770/1
Orientador
University of Nottingham School of Biosciences, Reino Unido
 Biotechnology and Biological Sciences Research Council
Em curso
2020 - 2020 BBSRC DTP Studenship: Artificial vs Synthetic bioolgy approaches for electrically wiring of bacteria
-
Investigador responsável
Biotechnology and Biological Sciences Research Council
2014 - 2018 Differentiating cell state using nanoelectrochemical sensors for monitoring reactive oxygen species in real-time
BB/L017059/1
Investigador responsável
University of Nottingham School of Pharmacy, Reino Unido
 Biotechnology and Biological Sciences Research Council
Concluído
2016 - 2016 KTP: Innovate UK/Surescreen Diagnostics Limited. Develop, transfer andembed analytical bioscience expertise in the areas of diagnostic technology
-
Investigador
2015 - 2015 Artificial functional scaffolds for synthetic tissues
-
Investigador responsável
2014 - 2014 EPSRC Jump Start Research award made under the Engineering and Physical Sciences Research Council Centre in Innovative Manufacturing in Materials for Additive Manufacturing
-
Investigador
2012 - 2012 PSRC equipment sharing grant (PI) Electron Paramagnetic Resonance detection of ROS in response to macrophage stimulations by lipopolysaccharide
-
Investigador responsável
Engineering and Physical Sciences Research Council

Projeto

Designação Financiadores
2016 - 2019 Nottingham Research Fellowship: Developing electroceutics
-
Investigador responsável
Concluído
2013 - 2013 Leverhulme Early Career Fellowship: Interfacing Electrochemical Nano- Systems with Single Cell for Real-Time Cellular Communication
-
Investigador responsável
Leverhulme Trust

Outro

Designação Financiadores
2018 - 2018 EPSRC Block Grant for equipment
-
Investigador responsável
University of Nottingham School of Pharmacy, Reino Unido
 Engineering and Physical Sciences Research Council
Concluído
2017 - 2017 Awarded Studentship - EPSRC Regenerative Medicine CDT: Developing bioelectronics for treating cancer
-
Investigador responsável
Engineering and Physical Sciences Research Council
Em curso
2016 - 2016 Awarded Studentship - BBSRC Synbio: Hijacking electron transport systems
-
Investigador responsável
Biotechnology and Biological Sciences Research Council
2013 - 2013 RSC Analytical Biosciences Group travel bursary award
-
Investigador responsável
Royal Society of Chemistry
2013 - 2013 Best Paper Prize from college of EPS
-
Investigador responsável
Produções

Publicações

Artigo em revista
  1. Rawson, Frankie. "Iron-Catalysed Radical Polymerisation by Living Bacteria". Angewandte Chemie (2020): http://dx.doi.org/10.1002/ange.201915084.
    10.1002/ange.201915084
  2. Rawson, Frankie. "Wireless Nanobioelectronics for Electrical Intracellular Sensing". ACS Applied Nano Materials (2019): http://dx.doi.org/10.1021/acsanm.9b01374.
    10.1021/acsanm.9b01374
  3. Rawson, Frankie. "Wireless Bioelectronics Towards Treatment of Glioblastoma Multiforme". Neuro-Oncology (2019): http://dx.doi.org/10.1093/neuonc/noz167.062.
    10.1093/neuonc/noz167.062
  4. Rawson, Frankie. "Multifunctional Bioinstructive 3D Architectures to Modulate Cellular Behavior". Advanced Functional Materials (2019): http://dx.doi.org/10.1002/adfm.201902016.
    10.1002/adfm.201902016
  5. Rawson, Frankie. "Real-time bacterial detection with an intracellular ROS sensing platform". Biosensors and Bioelectronics (2019): http://dx.doi.org/10.1016/j.bios.2019.111430.
    10.1016/j.bios.2019.111430
  6. Rawson, Frankie. "Mechanistic insight into heterogeneity of trans-plasma membrane electron transport in cancer cell types". Biochimica et Biophysica Acta (BBA) - Bioenergetics (2019): http://dx.doi.org/10.1016/j.bbabio.2019.06.012.
    10.1016/j.bbabio.2019.06.012
  7. Rawson, Frankie. "Mammalian-Cell-Driven Polymerisation of Pyrrole". ChemBioChem (2019): http://dx.doi.org/10.1002/cbic.201800630.
    10.1002/cbic.201800630
  8. Rawson, Frankie. "Reversible, High-Affinity Surface Capturing of Proteins Directed by Supramolecular Assembly". ACS Applied Materials & Interfaces (2019): http://dx.doi.org/10.1021/acsami.9b00927.
    10.1021/acsami.9b00927
  9. Rawson, Frankie. "Remotely Controlled in Situ Growth of Silver Microwires Forming Bioelectronic Interfaces". ACS Applied Materials & Interfaces (2019): http://dx.doi.org/10.1021/acsami.8b22075.
    10.1021/acsami.8b22075
  10. Rawson, Frankie. "Electrochemically stimulating developments in bioelectronic medicine". Bioelectronic Medicine (2018): http://dx.doi.org/10.1186/s42234-018-0001-z.
    10.1186/s42234-018-0001-z
  11. Rawson, Frankie. "New Perspectives on Iron Uptake in Eukaryotes". Frontiers in Molecular Biosciences (2018): http://dx.doi.org/10.3389/fmolb.2018.00097.
    10.3389/fmolb.2018.00097
  12. Sherman, H.G.; Jovanovic, C.; Stolnik, S.; Rawson, F.J.. "Electrochemical System for the Study of Trans-Plasma Membrane Electron Transport in Whole Eukaryotic Cells". Analytical Chemistry 90 4 (2018): 2780-2786. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042255880&partnerID=MN8TOARS.
    10.1021/acs.analchem.7b04853
  13. Hicks, J.M.; Wong, Z.Y.; Scurr, D.J.; Silman, N.; Jackson, S.K.; Mendes, P.M.; Aylott, J.W.; Rawson, F.J.. "Tailoring the Electrochemical Properties of Carbon Nanotube Modified Indium Tin Oxide via in Situ Grafting of Aryl Diazonium". Langmuir 33 20 (2017): 4924-4933. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019843640&partnerID=MN8TOARS.
    10.1021/acs.langmuir.7b00494
  14. Zarrar Hussein; Frankie J. Rawson; Pola G. Oppenheimer; Aaron Acton; Paula M. Mendes. "Length-Selective Chemical Assembly of Vertically Aligned Carbon Nanotubes". Adv. Mater. Interfaces (2016): n/a-n/a. http://dx.doi.org/10.1002/admi.201500860.
    10.1002/admi.201500860
  15. Rawson, F.J.; Cole, M.T.; Hicks, J.M.; Aylott, J.W.; Milne, W.I.; Collins, C.M.; Jackson, S.K.; Silman, N.J.; Mendes, P.M.. "Electrochemical communication with the inside of cells using micro-patterned vertical carbon nanofibre electrodes". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85000716940&partnerID=MN8TOARS.
    10.1038/srep37672
  16. Frankie J. Rawson; Jacqueline Hicks; Nicholas Dodd; Wondwossen Abate; David J. Garrett; Nga Yip; Gyorgy Fejer; et al. "Fast, Ultrasensitive Detection of Reactive Oxygen Species Using a Carbon Nanotube Based-Electrocatalytic Intracellular Sensor". ACS Appl. Mater. Interfaces 7 42 (2015): 23527-23537. http://dx.doi.org/10.1021/acsami.5b06493.
    10.1021/acsami.5b06493
  17. Frankie James Rawson. "New dimensions in controlling cellular function with electroceutics". Therapeutic Delivery 6 1 (2015): 5-8. http://dx.doi.org/10.4155/tde.14.105.
    10.4155/tde.14.105
  18. Alex Stephenson-Brown; Sue Yong; Muhammad H. Mansor; Zarrar Hussein; Nga-Chi Yip; Paula M. Mendes; John S. Fossey; Frankie J. Rawson. "Electronic communication of cells with a surface mediated by boronic acid saccharide interactions". Chem. Commun. 51 97 (2015): 17213-17216. http://dx.doi.org/10.1039/c5cc04311e.
    10.1039/c5cc04311e
  19. Hao Zhou; Qing Liu; Frankie J. Rawson; Wei Ma; Da-Wei Li; Di Li; Yi-Tao Long. "Optical monitoring of faradaic reaction using single plasmon-resonant nanorods functionalized with graphene". Chem. Commun. 51 15 (2015): 3223-3226. http://dx.doi.org/10.1039/c4cc07939f.
    10.1039/c4cc07939f
  20. Minhaj Lashkor; Frankie J. Rawson; Alex Stephenson-Brown; Jon A. Preece; Paula M. Mendes. "Electrically-driven modulation of surface-grafted RGD peptides for manipulation of cell adhesion". Chem. Commun. 50 98 (2014): 15589-15592. http://dx.doi.org/10.1039/c4cc06649a.
    10.1039/c4cc06649a
  21. Minhaj Lashkor; Frankie J. Rawson; Jon A. Preece; Paula M. Mendes. "Switching specific biomolecular interactions on surfaces under complex biological conditions". Analyst 139 21 (2014): 5400-5408. http://dx.doi.org/10.1039/c4an01225a.
    10.1039/c4an01225a
  22. Nga-Chi Yip; Frankie J Rawson; Chi Wai Tsang; Paula M Mendes. "Real-time electrocatalytic sensing of cellular respiration". Biosensors and Bioelectronics 57 (2014): 303-309. http://dx.doi.org/10.1016/j.bios.2014.01.059.
    10.1016/j.bios.2014.01.059
  23. Frankie J. Rawson; Alison J. Downard; Keith H. Baronian. "Electrochemical detection of intracellular and cell membrane redox systems in Saccharomyces cerevisiae". Sci. Rep. 4 (2014): http://dx.doi.org/10.1038/srep05216.
    10.1038/srep05216
  24. Chao Jing; Frankie James Rawson; Hao Zhou; Xin Shi; Wen-Hui Li; Da-Wei Li; Yi-Tao Long. "New Insights into Electrocatalysis Based on Plasmon Resonance for the Real-Time Monitoring of Catalytic Events on Single Gold Nanorods". Anal. Chem. 86 11 (2014): 5513-5518. http://dx.doi.org/10.1021/ac500785u.
    10.1021/ac500785u
  25. Parvez Iqbal; Frankie J. Rawson; Watson K.-W. Ho; Siu-Fung Lee; Ken Cham-Fai Leung; Xingyong Wang; Akash Beri; et al. "Surface Molecular Tailoring Using pH-Switchable Supramolecular Dendron-Ligand Assemblies". ACS Appl. Mater. Interfaces 6 9 (2014): 6264-6274. http://dx.doi.org/10.1021/am501613c.
    10.1021/am501613c
  26. Chun L. Yeung; Xingyong Wang; Minhaj Lashkor; Eleonora Cantini; Frankie J. Rawson; Parvez Iqbal; Jon A. Preece; Jing Ma; Paula M. Mendes. "Modulation of Biointeractions by Electrically Switchable Oligopeptide Surfaces: Structural Requirements and Mechanism". Adv. Mater. Interfaces 1 2 (2014): n/a-n/a. http://dx.doi.org/10.1002/admi.201300085.
    10.1002/admi.201300085
  27. Rawson, F. J.; Yeung, C. L.; Jackson, S. K.; Mendes, P. M.. "Tailoring 3D Single-Walled Carbon Nanotubes Anchored to Indium Tin Oxide for Natural Cellular Uptake and Intracellular Sensing". Nano Letters 13 1 (2013): 1-8. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000313142300001&KeyUID=WOS:000313142300001.
    10.1021/nl203780d
  28. Rawson, F J; Yeung, C L; Jackson, S K; Mendes, P M. "Intracellular 'wiring' for real-time cell communication.". Nano reviews 4 (2013): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:23956819&KeyUID=MEDLINE:23956819.
    10.3402/nano.v4i0.22429
  29. Pranzetti, Alice; Mieszkin, Sophie; Iqbal, Parvez; Rawson, Frankie J.; Callow, Maureen E.; Callow, James A.; Koelsch, Patrick; Preece, Jon A.; Mendes, Paula M.. "An Electrically Reversible Switchable Surface to Control and Study Early Bacterial Adhesion Dynamics in Real-Time". Advanced Materials 25 15 (2013): 2181-2185. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000317664700011&KeyUID=WOS:000317664700011.
    10.1002/adma.201204880
  30. Cait M. Costello; Chun L. Yeung; Frankie J. Rawson; Paula M. Mendes. "Application of nanotechnology to control bacterial adhesion and patterning on material surfaces". Journal of Experimental Nanoscience 7 6 (2012): 634-651. http://dx.doi.org/10.1080/17458080.2012.740640.
    10.1080/17458080.2012.740640
  31. Frankie J. Rawson; Andrew J. Gross; David J. Garrett; Alison J. Downard; Keith.H.R. Baronian. "Mediated electrochemical detection of electron transfer from the outer surface of the cell wall of Saccharomyces cerevisiae". Electrochemistry Communications 15 1 (2012): 85-87. http://dx.doi.org/10.1016/j.elecom.2011.11.030.
    10.1016/j.elecom.2011.11.030
  32. David J. Garrett; Paula A. Brooksby; Frankie J. Rawson; Keith H. R. Baronian; Alison J. Downard. "Reproducible Fabrication of Robust, Renewable Vertically Aligned Multiwalled Carbon Nanotube/Epoxy Composite Electrodes". Anal. Chem. 83 21 (2011): 8347-8351. http://dx.doi.org/10.1021/ac201769t.
    10.1021/ac201769t
  33. Nicholas D. Haslett; Frankie J. Rawson; Frèdèric Barriëre; Gotthard Kunze; Neil Pasco; Ravi Gooneratne; Keith H.R. Baronian. "Characterisation of yeast microbial fuel cell with the yeast Arxula adeninivorans as the biocatalyst". Biosensors and Bioelectronics 26 9 (2011): 3742-3747. http://dx.doi.org/10.1016/j.bios.2011.02.011.
    10.1016/j.bios.2011.02.011
  34. Frankie J. Rawson; David J. Garrett; Donal Leech; Alison J. Downard; Keith H.R. Baronian. "Electron transfer from Proteus vulgaris to a covalently assembled, single walled carbon nanotube electrode functionalised with osmium bipyridine complex: Application to a whole cell biosensor". Biosensors and Bioelectronics 26 5 (2011): 2383-2389. http://dx.doi.org/10.1016/j.bios.2010.10.016.
    10.1016/j.bios.2010.10.016
  35. Chelikani, V.; Rawson, F.J.; Downard, A.J.; Gooneratne, R.; Kunze, G.; Pasco, N.; Baronian, K.H.R.. "Electrochemical detection of oestrogen binding protein interaction with oestrogen in Candida albicans cell lysate". Biosensors and Bioelectronics 26 9 (2011): 3737-3741. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955475579&partnerID=MN8TOARS.
    10.1016/j.bios.2011.01.016
  36. Roy M. Pemberton; Frankie J. Rawson; Jinsheng Xu; Robin Pittson; Guido A. Drago; John Griffiths; Simon K. Jackson; John P. Hart. "Application of screen-printed microband biosensors incorporated with cells to monitor metabolic effects of potential environmental toxins". Microchim Acta 170 3-4 (2010): 321-330. http://dx.doi.org/10.1007/s00604-010-0326-0.
    10.1007/s00604-010-0326-0
  37. Rawson, F.J.; Jackson, S.K.; Hart, J.P.. "Voltammetric behavior of DNA and its derivatives using screen printed carbon electrodes and its possible application in genotoxicity screening". Analytical Letters 43 10-11 (2010): 1790-1800. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954836517&partnerID=MN8TOARS.
    10.1080/00032711003653908
  38. Rawson, F.J.; Purcell, W.M.; Xu, J.; Pemberton, R.M.; Fielden, P.R.; Biddle, N.; Hart, J.P.. "A microband lactate biosensor fabricated using a water-based screen-printed carbon ink". Talanta 77 3 (2009): 1149-1154. http://www.scopus.com/inward/record.url?eid=2-s2.0-57149146028&partnerID=MN8TOARS.
    10.1016/j.talanta.2008.08.020
  39. Rawson, F.J.; Purcell, W.M.; Xu, J.; Cowell, D.C.; Fielden, P.R.; Biddle, N.; Hart, J.P.. "Fabrication and characterisation of novel screen-printed tubular microband electrodes, and their application to the measurement of hydrogen peroxide". Electrochimica Acta 52 25 (2007): 7248-7253. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547565536&partnerID=MN8TOARS.
    10.1016/j.electacta.2007.05.062
Livro
  1. Rawson, F.J.. Interfacing cells with nanostructured electrochemical sensors for enhanced biomedical sensing. 2014.