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Jacinta Serpa has a PhD in Human Biology by Faculdade de Medicina da Universidade do Porto (2005) and Graduated in Applied Biology by Universidade dos Açores (1997). Since, 2015 she is the head of Cancer Metabolism and Microenvironment Lab in Centro de estudos de Doenças Crónicas from NOVA Medical School (CEDOC|NMS) (http://cedoc.unl.pt/cancer-metabolism-and-microenvironment/) and Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG). She participated in more than 15 research projects and she has supervised 15 Master theses and 10 PhD Theses (5 ongoing). She is an expert in cancer biology with more than 20 years of experience and 42 peer-reviewed published research papers (1388 citations, H index 20, since 2017: 765 citations; H index 16). Her main fields of interest are: cancer metabolism, including metabolic adaptations allowing cancer cells survival in certain stressful microenvironmental conditions, such as hypoxia and exposure to drugs; tumor microenvironment and the metabolic and signaling cross-talks responsible for the modulation of cancer cells behavior by other cancer cells and by stromal cells, and the regulation of biological phenomena crucial for tumor growth and disease progression.
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Identificação

Identificação pessoal

Nome completo
Jacinta Serpa
Data de nascimento
1974/04/03
Género
Feminino

Nomes de citação

  • Serpa, Jacinta

Identificadores de autor

Ciência ID
2610-7C0D-38F2
ORCID iD
0000-0002-1548-5907

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Clínica
  • Ciências Naturais - Ciências Biológicas

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2005
Concluído
 Biologia Humana (Doutoramento)
Especialização em Sem especialidade
Universidade do Porto Faculdade de Medicina, Portugal
"Scretor and Lewis Phenotype / Genotype and Their Relevance for Helicobater Pylori Infection" (TESE/DISSERTAÇÃO)
1997
Concluído
 Biologia (Licenciatura)
Universidade dos Açores, Portugal
 15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2006/01/03 - Atual Investigador (Investigação) Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
2000/01 - 2005/12 Investigador (Investigação) Universidade do Porto, Portugal
1998/01 - 2000/12 Investigador (Investigação) Laboratório de Energia, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2008/08/28 - Atual Professor Auxiliar (Docente Universitário) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 - 2018 Professor Auxiliar (Docente Universitário) Universidade Nova de Lisboa, Portugal

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2013 - 2016 Conselho científico/técnico-científico ou orgão correspondente Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Projetos

Projeto

Designação Financiadores
2020/10/01 - 2023/09/30 Urease Next-Generation Inhibition Therapy
PTDC/MED-QUI/3542/2020
Investigador
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2021/06/01 - 2022/05/31 Cystathionine-ß- synthase inhibition as a therapeutic approach in colorectal and lung cancer
SpeedGrant
Investigador responsável
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Merck KGaA
Em curso
2018/10/01 - 2021/09/30 Dendrimer-based Report-Eradication Antineoplasic Machines
PTDC/MEC-ONC/29327/2017
Investigador
2016/04/01 - 2019/03/31 (per)Sulfidomics: benchmarking mechanisms underlying drug toxicity and drug resistance in precision medicine
iNOVA4Health- project 21
Investigador
2017/03/01 - 2019/02/28 Targeting monocytes as angiogenesis promoters in cancer- New application for old drugs; Funded by iNOVA4Health, FCT
iNOVA4Health Project-35
Investigador responsável
2015/03/01 - 2018/02/28 Ovarian cancer (OC) a suitable model to define metabolic profile as a tool to predict chemoresistance
iNOVA4Health- project 4
Investigador responsável
2015/04/01 - 2017/03/31 Molecular mechanisms of cell migration and invasion: developing a new strategy to impair tumor progression
iNOVA4Health-project 6
PTDC\BIMMEC\4905\2014
Investigador
2014/04/01 - 2016/03/31 Biomarcadores e potenciais alvos terapêuticos em carcinoma do colo uterino
Terry Fox 2014
Investigador
2013/04/01 - 2016/03/31 Risco de Cancro Familiar e Individual – Identificação de Novos Genes
Projecto TVI
Investigador
2014/03/01 - 2016/02/28 CarCHistonOmic
CQE/2014_031-IST-ID
Investigador
2013/05/01 - 2015/09/30 Metaboloma do líquido cefalorraquidiano em doentes oncológicos
PTDC/BIM-ONC/1242/2012
Investigador
2011/04/01 - 2013/03/31 Monocarboxylate transporters (MCTs) as putative therapeutic targets in acute myeloid leukaemia (AML)
Terry Fox 2011
Investigador responsável
2011/04/01 - 2013/03/31 Role of Lactate Rich Microenvironment in Uterine Cervix Cancer Progression
FLAD- 2011
Investigador responsável
2007/04/01 - 2009/03/31 Role of butyrate rich colon microenvironment in tumour progression
FLAD-2007
Investigador
2002/01/01 - 2005/12/31 Characterization of gastric lesions associated with Helicobacter pylori infection in the workers of a shipyard from Viana do Castelo
FC-54918
Bolseiro de Doutoramento
2002/10/01 - 2005/09/30 egulation of aberrant MUC2 mucin gene expression in intestinal metaplasia, mucinous gastric carcinomas and gastric carcinoma cell lines: role of methylation and putative transcription factors
POCTI/CBO/39075/2001
Bolseiro de Doutoramento
1999/03/01 - 2001/02/28 Human fucosyltransferases: membrane organization and regulation of the in vivo activity
P/BIO/12072/98
Bolseiro de Investigação
1998/06/01 - 2000/07/31 Mucins in the pathophysiology of inflammatory diseases of the bronchial and gastrointestinal epithelia
BMH4-CT98-3222
Bolseiro de Investigação
Produções

Publicações

Artigo em conferência
  1. Patrícia C. Grácio; Clara Gonçalves-Dias; Filipa Lopes-Coelho; E.C. Monteiro; Jacinta Serpa; Cláudia L. Da Silva; Pereira SA. "Changes in N-acetyltransferase 8 in kidney tubular cell". 2019.
    10.1109/ENBENG.2019.8692517
Artigo em revista
  1. Catarina Freitas-Dias; Filipe Gonçalves; Filipa Martins; Isabel Lemos; Luís G. Gonçalves; Jacinta Serpa. "Interaction between NSCLC Cells, CD8+ T-Cells and Immune Checkpoint Inhibitors Potentiates Coagulation and Promotes Metabolic Remodeling—New Cues on CAT-VTE". Cells (2024): https://doi.org/10.3390/cells13040305.
    10.3390/cells13040305
  2. Ana Hipólito; Renato Xavier; Cheila Brito; Ana Tomás; Isabel Lemos; Luís C. Cabaço; fernanda silva; et al. "BRD9 status is a major contributor for cysteine metabolic remodeling through MST and EAAT3 modulation in malignant melanoma". Biochimica et biophysica acta. Molecular basis of disease 1870 2 (2024): https://novaresearch.unl.pt/en/publications/840b30bb-52c6-42da-96cc-1c144261dd44.
    10.1016/j.bbadis.2023.166983
  3. Ana Hipólito; Cindy Mendes; Filipa Martins; Isabel Lemos; Inês Francisco; Fernando Cunha; Teresa Almodôvar; et al. "H2S-Synthesizing Enzymes Are Putative Determinants in Lung Cancer Management toward Personalized Medicine". Antioxidants (2023): https://www.mdpi.com/2076-3921/13/1/51.
    10.3390/antiox13010051
  4. Sofia C. Nunes; Joana Sousa; Fernanda Silva; Margarida Silveira; António Guimarães; Jacinta Serpa; Ana Félix; Luís G. Gonçalves. "Peripheral Blood Serum NMR Metabolomics Is a Powerful Tool to Discriminate Benign and Malignant Ovarian Tumors". Metabolites (2023): https://doi.org/10.3390/metabo13090989.
    10.3390/metabo13090989
  5. Cindy Mendes; Isabel Lemos; Inês Francisco; Teresa Almodôvar; Fernando Cunha; Cristina Albuquerque; Luis G Goncalves; Jacinta Serpa. "NSCLC presents metabolic heterogeneity, and there is still some leeway for EGF stimuli in EGFR-mutated NSCLC". Lung Cancer 182 (2023): https://novaresearch.unl.pt/en/publications/e2577263-906d-4c54-8bb1-e6fecaec8ac8.
    10.1016/j.lungcan.2023.107283
  6. Filipa Martins; David van der Kellen; Luís G. Gonçalves; Jacinta Serpa. "Metabolic Profiles Point Out Metabolic Pathways Pivotal in Two Glioblastoma (GBM) Cell Lines, U251 and U-87MG". Biomedicines (2023): https://doi.org/10.3390/biomedicines11072041.
    10.3390/biomedicines11072041
  7. Filipa Lopes-Coelho; Filipa Martins; Ana Hipólito; Sílvia V. Conde; Sofia A. Pereira; Luís G. Gonçalves; Jacinta Serpa. "A Metabolic Signature to Monitor Endothelial Cell Differentiation, Activation, and Vascular Organization". Biomedicines (2022): https://doi.org/10.3390/biomedicines10092293.
    10.3390/biomedicines10092293
  8. Rita Mendes; Gonçalo Graça; Fernanda Silva; Ana C. L. Guerreiro; Patrícia Gomes-Alves; Jacinta Serpa; Erwin R. Boghaert; et al. "Exploring Metabolic Signatures of Ex Vivo Tumor Tissue Cultures for Prediction of Chemosensitivity in Ovarian Cancer". Cancers (2022): https://doi.org/10.3390/cancers14184460.
    10.3390/cancers14184460
  9. Sofia Gouveia-Fernandes; Armanda Rodrigues; Carolina Nunes; Catarina Charneira; João Nunes; Jacinta Serpa; Alexandra M.M. Antunes. "Glycidamide and cis-2-butene-1,4-dial (BDA) as potential carcinogens and promoters of liver cancer - An in vitro study". Food and Chemical Toxicology (2022): https://doi.org/10.1016/j.fct.2022.113251.
    10.1016/j.fct.2022.113251
  10. Filipa Lopes-Coelho; Sofia Nunes; Filipa Martins; Ana Hipolito; Sofia Gouveia-Fernandes; Germana Domingues; Bernardete F. Melo; et al. "Propranolol therapy for cerebral cavernous malformations". World Academy of Sciences Journal 4 3 (2022): https://novaresearch.unl.pt/en/publications/2de56f91-0662-4c59-94ee-de2b4003af30.
    10.3892/wasj.2022.158
  11. Maria João Correia; António Pimpão; Dalila Guedes Ferreira Henriques Fernandes; Judit Morello; Catarina O. Sequeira; Joaquim Calado; AMM Antunes; et al. "Cysteine as a Multifaceted Player in Kidney, the Cysteine-Related Thiolome and Its Implications for Precision Medicine". Molecules (2022): https://www.mdpi.com/1420-3049/27/4/1416.
    10.3390/molecules27041416
  12. Correia, Maria João; Pimpão, António B.; Lopes-Coelho, Filipa; Sequeira, Catarina O.; Coelho, Nuno R.; Gonçalves-Dias, Clara; Barouki, Robert; et al. "Aryl Hydrocarbon Receptor and Cysteine Redox Dynamics Underlie (Mal)adaptive Mechanisms to Chronic Intermittent Hypoxia in Kidney Cortex". Antioxidants 10 9 (2021): 1484. http://dx.doi.org/10.3390/antiox10091484.
    10.3390/antiox10091484
  13. Nunes, Sofia C.; Ramos, Cristiano; Santos, Inês; Mendes, Cindy; Silva, Fernanda; Vicente, João B.; Pereira, Sofia A.; et al. "Cysteine Boosts Fitness Under Hypoxia-Mimicked Conditions in Ovarian Cancer by Metabolic Reprogramming". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.722412.
    10.3389/fcell.2021.722412
  14. Hipólito, Ana; Martins, Filipa; Mendes, Cindy; Lopes-Coelho, Filipa; Serpa, Jacinta. "Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis". Frontiers in Oncology 11 (2021): http://dx.doi.org/10.3389/fonc.2021.656851.
    10.3389/fonc.2021.656851
  15. Lopes-Coelho, Filipa; Martins, Filipa; Hipólito, Ana; Mendes, Cindy; Sequeira, Catarina O.; Pires, Rita F.; Almeida, António M.; et al. "The Activation of Endothelial Cells Relies on a Ferroptosis-Like Mechanism: Novel Perspectives in Management of Angiogenesis and Cancer Therapy". Frontiers in Oncology 11 (2021): http://dx.doi.org/10.3389/fonc.2021.656229.
    10.3389/fonc.2021.656229
  16. Filipa Lopes-Coelho; Filipa Martins; Sofia A. Pereira; Jacinta Serpa. "Anti-Angiogenic Therapy: Current Challenges and Future Perspectives". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms22073765.
    10.3390/ijms22073765
  17. André, Saudade; Pinto, António E; Silva, Giovani L; Silva, Fernanda; Serpa, Jacinta; Félix, Ana. "Male Breast Cancer—Immunohistochemical Patterns and Clinical Relevance of FASN, ATF3, and Collagen IV". Breast Cancer: Basic and Clinical Research 15 (2021): 117822342110024. http://dx.doi.org/10.1177/11782234211002496.
    10.1177/11782234211002496
  18. Bonifácio, Vasco D. B.; Pereira, Sofia A.; Serpa, Jacinta; Vicente, João B.. "Cysteine metabolic circuitries: druggable targets in cancer". British Journal of Cancer 124 5 (2020): 862-879. http://dx.doi.org/10.1038/s41416-020-01156-1.
    10.1038/s41416-020-01156-1
  19. Filipa Martins; Luís G. Gonçalves; Marta Pojo; Jacinta Serpa. "Take Advantage of Glutamine Anaplerosis, the Kernel of the Metabolic Rewiring in Malignant Gliomas". Biomolecules (2020): https://doi.org/10.3390/biom10101370.
    10.3390/biom10101370
  20. Hipólito, Ana; Nunes, Sofia C.; Vicente, João B.; Serpa, Jacinta. "Cysteine Aminotransferase (CAT): A Pivotal Sponsor in Metabolic Remodeling and an Ally of 3-Mercaptopyruvate Sulfurtransferase (MST) in Cancer". Molecules 25 17 (2020): 3984. http://dx.doi.org/10.3390/molecules25173984.
    10.3390/molecules25173984
  21. Mendes, Cindy; Serpa, Jacinta. "Revisiting lactate dynamics in cancer—a metabolic expertise or an alternative attempt to survive?". Journal of Molecular Medicine 98 10 (2020): 1397-1414. http://dx.doi.org/10.1007/s00109-020-01965-0.
    10.1007/s00109-020-01965-0
  22. Adriana Cruz; Pedro Mota; Cristiano Ramos; Rita F Pires; Cindy Mendes; José P Silva; Sofia C Nunes; Vasco D B Bonifácio; Jacinta Serpa. "Polyurea Dendrimer Folate-Targeted Nanodelivery of l-Buthionine sulfoximine as a Tool to Tackle Ovarian Cancer Chemoresistance". Antioxidants 9 2 (2020): https://novaresearch.unl.pt/en/publications/955ef006-8fc9-4c7f-b198-53f5251d8b33.
    10.3390/antiox9020133
  23. Lopes-Coelho, Filipa; Silva, Fernanda; Gouveia-Fernandes, Sofia; Martins, Carmo; Lopes, Nuno; Domingues, Germana; Brito, Catarina; et al. "Monocytes as Endothelial Progenitor Cells (EPCs), Another Brick in the Wall to Disentangle Tumor Angiogenesis". Cells 9 1 (2020): 107. http://dx.doi.org/10.3390/cells9010107.
    10.3390/cells9010107
  24. Mendes, Cindy; Serpa, Jacinta. "Metabolic Remodelling: An Accomplice for New Therapeutic Strategies to Fight Lung Cancer". Antioxidants 8 12 (2019): 603. http://dx.doi.org/10.3390/antiox8120603.
    10.3390/antiox8120603
  25. Santos, Inês; Ramos, Cristiano; Mendes, Cindy; Sequeira, Catarina O.; Tomé, Catarina S.; Fernandes, Dalila G.H.; Mota, Pedro; et al. "Targeting Glutathione and Cystathionine ß-Synthase in Ovarian Cancer Treatment by Selenium–Chrysin Polyurea Dendrimer Nanoformulation". Nutrients 11 10 (2019): 2523. http://dx.doi.org/10.3390/nu11102523.
    10.3390/nu11102523
  26. Mendes, Cindy; Lopes-Coelho, Filipa; Ramos, Cristiano; Martins, Filipa; Santos, Inês; Rodrigues, Armanda; Silva, Fernanda; André, Saudade; Serpa, Jacinta. "Unraveling FATP1, regulated by ER-ß, as a targeted breast cancer innovative therapy". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-50531-3.
    10.1038/s41598-019-50531-3
  27. Casalou, Cristina; Faustino, Alexandra; Silva, Fernanda; Ferreira, Inês C.; Vaqueirinho, Daniela; Ferreira, Andreia; Castanheira, Pedro; et al. "Arl13b Regulates Breast Cancer Cell Migration and Invasion by Controlling Integrin-Mediated Signaling". Cancers 11 10 (2019): 1461. http://dx.doi.org/10.3390/cancers11101461.
    10.3390/cancers11101461
  28. Mota, Pedro; Pires, Rita F.; Serpa, Jacinta; Bonifácio, Vasco D. B.. "l-Buthionine Sulfoximine Detection and Quantification in Polyurea Dendrimer Nanoformulations". Molecules 24 17 (2019): 3111. http://dx.doi.org/10.3390/molecules24173111.
    10.3390/molecules24173111
  29. Nunes, João; Charneira, Catarina; Nunes, Carolina; Gouveia-Fernandes, Sofia; Serpa, Jacinta; Morello, Judit; Antunes, Alexandra M. M.. "A Metabolomics-Inspired Strategy for the Identification of Protein Covalent Modifications". Frontiers in Chemistry 7 (2019): http://dx.doi.org/10.3389/fchem.2019.00532.
    10.3389/fchem.2019.00532
  30. Serpa, Jacinta de Fátima Rosário. "Detection of human ovarian carcinoma from blood samples using scent dogs". Acta Obstet Ginecol Port (2019): http://www.scielo.mec.pt/scielo.php?script=sci_abstract&pid=S1646-58302019000300003&lng=pt&nrm=iso.
    Publicado
  31. Lopes-Coelho, Filipa; Silva, Fernanda; Hipólito, Ana; Cardoso, Bruno A.; Serpa, Jacinta. "Acetylation drives hepatocyte nuclear factor 1ß stability by blocking proteasome-mediated degradation". Journal of Cellular Biochemistry 120 6 (2018): 9337-9344. http://dx.doi.org/10.1002/jcb.28209.
    10.1002/jcb.28209
  32. Sofia Nunes; Jacinta Serpa. "Glutathione in Ovarian Cancer: A Double-Edged Sword". International Journal of Molecular Sciences 19 7 (2018): 1882-1882. https://doi.org/10.3390/ijms19071882.
    10.3390/ijms19071882
  33. Nunes, Sofia C.; Ramos, Cristiano; Lopes-Coelho, Filipa; Sequeira, Catarina O.; Silva, Fernanda; Gouveia-Fernandes, Sofia; Rodrigues, Armanda; et al. "Cysteine allows ovarian cancer cells to adapt to hypoxia and to escape from carboplatin cytotoxicity". Scientific Reports 8 1 (2018): http://dx.doi.org/10.1038/s41598-018-27753-y.
    10.1038/s41598-018-27753-y
  34. Nunes, Sofia C.; Lopes-Coelho, Filipa; Gouveia-Fernandes, Sofia; Ramos, Cristiano; Pereira, Sofia A.; Serpa, Jacinta. "Cysteine boosters the evolutionary adaptation to CoCl2 mimicked hypoxia conditions, favouring carboplatin resistance in ovarian cancer". BMC Evolutionary Biology 18 1 (2018): http://dx.doi.org/10.1186/s12862-018-1214-1.
    10.1186/s12862-018-1214-1
  35. de Alteriis, Elisabetta; Cartenì, Fabrizio; Parascandola, Palma; Serpa, Jacinta; Mazzoleni, Stefano. "Revisiting the Crabtree/Warburg effect in a dynamic perspective: a fitness advantage against sugar-induced cell death". Cell Cycle 17 6 (2018): 688-701. http://dx.doi.org/10.1080/15384101.2018.1442622.
    10.1080/15384101.2018.1442622
  36. Lopes-Coelho, Filipa; Gouveia-Fernandes, Sofia; Serpa, Jacinta. "Metabolic cooperation between cancer and non-cancerous stromal cells is pivotal in cancer progression". Tumor Biology 40 2 (2018): 101042831875620. http://dx.doi.org/10.1177/1010428318756203.
    10.1177/1010428318756203
  37. Lopes-Coelho, Filipa; André, Saudade; Félix, Ana; Serpa, Jacinta. "Breast cancer metabolic cross-talk: Fibroblasts are hubs and breast cancer cells are gatherers of lipids". Molecular and Cellular Endocrinology 462 (2018): 93-106. http://dx.doi.org/10.1016/j.mce.2017.01.031.
    10.1016/j.mce.2017.01.031
  38. Graça, Gonçalo; Desterro, Joana; Sousa, Joana; Fonseca, Carlos; Silveira, Margarida; Serpa, Jacinta; Carvalho, Tânia; da Silva, Maria G.; Gonçalves, Luís G.. "Identification of putative biomarkers for leptomeningeal invasion in B-cell non-Hodgkin lymphoma by NMR metabolomics". Metabolomics 13 11 (2017): http://dx.doi.org/10.1007/s11306-017-1269-9.
    10.1007/s11306-017-1269-9
  39. Lopes-Coelho, Filipa; Nunes, Carolina; Gouveia-Fernandes, Sofia; Rosas, Rita; Silva, Fernanda; Gameiro, Paula; Carvalho, Tânia; et al. "Monocarboxylate transporter 1 (MCT1), a tool to stratify acute myeloid leukemia (AML) patients and a vehicle to kill cancer cells". Oncotarget 8 47 (2017): http://dx.doi.org/10.18632/oncotarget.20294.
    10.18632/oncotarget.20294
  40. Grilo, Nádia M.; João Correia, M.; Miranda, Joana P.; Cipriano, Madalena; Serpa, Jacinta; Matilde Marques, M.; Monteiro, Emília C.; et al. "Unmasking efavirenz neurotoxicity: Time matters to the underlying mechanisms". European Journal of Pharmaceutical Sciences 105 (2017): 47-54. http://dx.doi.org/10.1016/j.ejps.2017.05.010.
    10.1016/j.ejps.2017.05.010
  41. Lopes-Coelho, Filipa; Gouveia-Fernandes, Sofia; Serpa, Jacinta. "Metabolic Dynamics in Breast Cancer: Cooperation between Cancer and Stromal Cells". Journal of Clinical Breast Cancer Research (2017): https://pdfs.semanticscholar.org/f36c/b516eea94a3b1864b92f5bb88766087234a8.pdf.
    Publicado
  42. Silva, Fernanda; Félix, Ana; Serpa, Jacinta. "Functional redundancy of the Notch pathway in ovarian cancer cell lines". Oncology Letters 12 4 (2016): 2686-2691. http://dx.doi.org/10.3892/ol.2016.4959.
    10.3892/ol.2016.4959
  43. Serpa, Jacinta de Fátima Rosário. "Colorectal Cancer Aggressiveness is Related to Fibronectin Over Expression, Driving the Activation of SDF-1:CXCR4 Axis". Journal of Cancer and Clinical Research (2016):
    Publicado
  44. Silva, Lidia Santos; Goncalves, Luis Gafeira; Silva, Fernanda; Domingues, Germana; Maximo, Valdemar; Ferreira, Joana; Lam, Eric W.-F.; et al. "STAT3:FOXM1 and MCT1 drive uterine cervix carcinoma fitness to a lactate-rich microenvironment". Tumor Biology 37 4 (2015): 5385-5395. http://dx.doi.org/10.1007/s13277-015-4385-z.
    10.1007/s13277-015-4385-z
  45. Lopes-Coelho, Filipa; Gouveia-Fernandes, Sofia; Gonçalves, Luís G; Nunes, Carolina; Faustino, Inês; Silva, Fernanda; Félix, Ana; Pereira, Sofia A; Serpa, Jacinta. "HNF1ß drives glutathione (GSH) synthesis underlying intrinsic carboplatin resistance of ovarian clear cell carcinoma (OCCC)". Tumor Biology 37 4 (2015): 4813-4829. http://dx.doi.org/10.1007/s13277-015-4290-5.
    10.1007/s13277-015-4290-5
  46. Serpa, Jacinta; Dias, Sergio. "Metabolic cues from the microenvironment act as a major selective factor for cancer progression and metastases formation". Cell Cycle 10 2 (2014): 180-181. http://www.tandfonline.com/doi/abs/10.4161/cc.10.2.14476.
    Publicado • 10.4161/cc.10.2.14476
  47. Gomes, A.L.; Carvalho, T.; Serpa, J.; Torre, C.; Dias, S.. "Hypercholesterolemia promotes bone marrow cell mobilization by perturbing the SDF-1:CXCR4 axis (Blood (2010) 115, 19 (3886-3894))". Blood 118 18 (2011): 5060-5063. http://www.scopus.com/inward/record.url?eid=2-s2.0-80855133505&partnerID=MN8TOARS.
    10.1182/blood-2011-08-377390
  48. Cachaço, Ana Sofia; Carvalho, Tânia; Santos, Ana Cristina; Igreja, Cátia; Fragoso, Rita; Osório, Catarina; Ferreira, Manuela; et al. "TNF-a Regulates the Effects of Irradiation in the Mouse Bone Marrow Microenvironment". PLoS ONE 5 2 (2010): e8980. http://dx.doi.org/10.1371/journal.pone.0008980.
    10.1371/journal.pone.0008980
  49. Serpa, J.; Caiado, F.; Carvalho, T.; Torre, C.; Goncalves, L. G.; Casalou, C.; Lamosa, P.; et al. "Butyrate-rich Colonic Microenvironment Is a Relevant Selection Factor for Metabolically Adapted Tumor Cells". Journal of Biological Chemistry 285 50 (2010): 39211-39223. http://www.jbc.org/content/285/50/39211.full.
    Publicado • 10.1074/jbc.M110.156026
  50. Azevedo, M; Eriksson, S; Mendes, N; Serpa, J.; Figueiredo, C; Resende, LP; Ruvoën-Clouet, N; et al. "Infection by Helicobacter pylori expressing the BabA adhesin is influenced by the secretor phenotype". The Journal of Pathology 215 3 (2008): 308-316. http://www.ncbi.nlm.nih.gov/pubmed/18498114.
    Publicado • 10.1002/path.2363
  51. Serpa, Jacinta; Mesquita, Patrícia; MENDES, Nuno; Oliveira, Carla; Almeida, Raquel; Santos-Silva, Filipe; Reis, Celso A.; LePendu, Jacques; David, Leonor. "Expression of Lea in gastric cancer cell lines depends on FUT3 expression regulated by promoter methylation". Cancer Letters 242 2 (2006): 191-197. http://www.ncbi.nlm.nih.gov/pubmed/16427187.
    Publicado • 10.1016/j.canlet.2005.11.009
  52. Mesquita, P.; Almeida, R.; Lunet, N; Reis, CA; Serpa, Jacinta de Fátima Rosário; SANTOS SILVA, Luis F.; Van Seuningen, I.; Barros, B; David, L. "Metaplasia - A Transdifferentiation process that facilitates cancer development. The model of gastric intestinal metaplasia". Critical Reviews in Oncogenesis 12 1 (2005): 3-26.
    Publicado
  53. Serpa J; Lunet N; Mendes N; Barros H; David L. "Lewis and Secretor status and Helicobacter pylori eradication.". (2004): http://europepmc.org/abstract/med/15473165.
    10.1017/S0950268804212900
  54. Serpa, Jacinta de Fátima Rosário; Lunet, N; Mendes, N; Barros, H; David, L. "Letter to the Editor: Lewis and Secretor status and Helicobacter pylori eradication". Epidemiol Infect 132 5 (2004): 998-999. http://www.ncbi.nlm.nih.gov/pubmed/15473165.
    Publicado
  55. Serpa, Jacinta; MENDES, Nuno; REIS, Celso A.; SANTOS SILVA, Luis F.; Almeida, Raquel; LE PENDU, Jacques; David, Leonor. "Two new FUT2 (fucosyltransferase 2 gene) missense polymorphisms, 739G¿A and 839T¿C, are partly responsible for non-secretor status in a Caucasian population from Northern Portugal". Biochemical Journal 383 3 (2004): 469-469. http://www.biochemj.org/bj/383/0469/bj3830469.htm.
    Publicado • 10.1042/BJ20040803
  56. Nogueira, Ana Margarida; Marques, Terezinha; Soares, Paula Cristina M.; David, Leonor; Reis, Celso A.; Serpa, Jacinta de Fátima Rosário; Queiroz, Dulciene M.; Rocha, Gifone A.; Rocha, Andr??ia C.. "Lewis Antigen Expression in Gastric Mucosa of Children: Relationship With Helicobacter pylori Infection". Journal of Pediatric Gastroenterology and Nutrition 38 1 (2004): 85-91.
    Publicado • 10.1097/00005176-200401000-00019
  57. Serpa, Jacinta; Almeida, Raquel; Oliveira, Carla; Silva, Filipe Santos; Silva, Elisabete; Reis, Celso; Le Pendu, Jacques; et al. "Lewis enzyme (a1-3/4 fucosyltransferase) polymorphisms do not explain the Lewis phenotype in the gastric mucosa of a Portuguese population". Journal of Human Genetics 48 4 (2003): 183-189. http://www.nature.com/jhg/journal/v48/n4/full/jhg200332a.html.
    Publicado • 10.1007/s10038-003-0007-5
  58. Mesquita, P.; Jonckheere, N.; Almeida, R.; Ducourouble, M.-P.; Serpa, J.; Silva, E.; Pigny, P.; et al. "Human MUC2 Mucin Gene Is Transcriptionally Regulated by Cdx Homeodomain Proteins in Gastrointestinal Carcinoma Cell Lines". Journal of Biological Chemistry 278 51 (2003): 51549-51556. http://www.jbc.org/content/278/51/51549.long.
    Publicado • 10.1074/jbc.M309019200
  59. V A Morais; Jacinta Serpa; Angelina de Sá Palma; Costa, T; L Maranga; Julia Costa; Morais, VA; et al. "Expression and characterization of recombinant human alpha-3/4-fucosyltransferase III from Spodoptera frugiperda (Sf9) and Trichoplusia ni (Tn) cells using the baculovirus expression system". Biochemical Journal 353 Pt 3 (2001): 719-25. https://novaresearch.unl.pt/en/publications/cf1789f7-f59a-4ddd-ab57-09e577c41a58.
    Publicado • 10.1042/0264-6021:3530719
  60. Silva, Elisabete; Teixeira, Ana; David, Leonor; Carneiro, Fátima; Reis, Celso A.; Sobrinho-Simões, Joana; Serpa, Jacinta; et al. "Mucins as key molecules for the classification of intestinal metaplasia of the stomach". Virchows Archiv 440 3 (2001): 311-317. http://link.springer.com/article/10.1007%2Fs004280100531.
    Publicado • 10.1007/s004280100531
Capítulo de livro
  1. Serpa, Jacinta de Fátima Rosário. "Recycling the interspecific relations with epithelial cells: bacteria and cancer metabolic symbiosis". In Tumor Microenvironment - The main driver of metabolic adaptation. 2020.
  2. Serpa, Jacinta de Fátima Rosário. "Endothelial cells (ECs) metabolism: a valuable piece to disentangle cancer biology". In Tumor Microenvironment - The main driver of metabolic adaptation. 2020.
    10.1007/978-3-030-34025-4_8
  3. Ana Hipólito; Cindy Mendes; Jacinta Serpa. "The Metabolic Remodelling in Lung Cancer and Its Putative Consequence in Therapy Response". 311-333. Springer, 2020.
    10.1007/978-3-030-34025-4_16
  4. Jacinta Serpa. "Metabolic Remodeling as a Way of Adapting to Tumor Microenvironment (TME), a Job of Several Holders". 1-34. Springer, 2020.
    10.1007/978-3-030-34025-4_1
  5. Nuno R. Coelho; Clara G. Dias; M. João Correia; Patrícia Grácio; Jacinta Serpa; E.C. Monteiro; Lucilia Diogo; Pereira SA. "Cysteine Oxidative Dynamics Underlies Hypertension and Kidney Dysfunction Induced by Chronic Intermittent Hypoxia". 83-88. Springer Nature, 2018.
    10.1007/978-3-319-91137-3
  6. Serpa, Jacinta de Fátima Rosário. "Uterine Cervix Cancer Cells Re-Establish the Natural Lactate Rich Microenvironment, favoring Disease Progression". In Research & Reviews on Cervical Cancer. e-Books, 2017.
  7. Germana Domingues; Sofia Gouveia-Fernandes; Jacinta Serpa. "Dynamics of VEGF-A and its Receptors in Cancer Vascularization – an Overview". iConcept Press Ltd, 2016.
Tese / Dissertação
  1. "CYSTEINE METABOLIC REMODELING: A METABOLIC MARKER FOR CANCER AGGRESSIVENESS AND A NOVEL PUTATIVE TARGET IN ONCOLOGICAL MANAGEMENT". Doutoramento, Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, 2024.
  2. "Impact of anti-CTLA4 and anti-PDL1 on the cross talk between cancer and immune cells, underlying CAT-VTE". Mestrado, Fundação da Faculdade de Ciências da Universidade de Lisboa, 2023.
  3. "THE ROLE OF GLUCAGON: GCGR AXIS IN PANCREATIC NEUROENDOCRINE TUMOURS (pNETs)". Mestrado, Universidade Nova de Lisboa Faculdade de Ciências Médicas, 2023.
  4. "UNRAVELLING THE PIVOTAL METABOLIC PATHWAYS OF MALIGNANT GLIOMAS (David Kellen)". Mestrado, Universidade Nova de Lisboa Faculdade de Ciências Médicas, 2021. https://run.unl.pt/handle/10362/129290.
  5. "Metabolic and gene expression profiles related to EGFR mutations in lung cancer (Isabel Lemos)". Mestrado, Universidade do Porto Faculdade de Medicina, 2021.
  6. "NOVEL MECHANISMS IN ANGIOGENESIS: OXIDATIVE STRESS AS A PROMOTER OF MONOCYTE-TO-ENDOTHELIAL CELL DIFFERENTIATION AND ENDOTHELIAL CELL ACTIVATION (Filipa Lopes-Coelho)". Doutoramento, Universidade Nova de Lisboa Faculdade de Ciências Médicas, 2021. https://run.unl.pt/handle/10362/115961.
  7. Serpa, Jacinta de Fátima Rosário. "xCT (SLC7A11)-Antiporter system role in ovarian carcinoma chemoresistance". Mestrado, Biblioteca Universitaria di Pisa, 2019.
  8. Serpa, Jacinta de Fátima Rosário. "Metabolic remodeling of endothelial cells upon hypoxia". Mestrado, Fundação da Faculdade de Ciências da Universidade de Lisboa, 2019.
  9. Serpa, Jacinta de Fátima Rosário. "Cysteine metabolism and pancreatic Neuroendocrine Tumours (PNETs) chemoresistance". Mestrado, Universidade Nova de Lisboa, 2019.
  10. Mendes, Cindy Alexandra Lopes. "Disclosing FATP1 as a therapeutic target in breast cancer". Mestrado, 2018. http://hdl.handle.net/10451/36437.
  11. Mota, Pedro Manuel Barbosa. "Dendrimer-based Report-Eradication Antineoplasic Machines". Mestrado, 2018. http://hdl.handle.net/10362/38193.
  12. Serpa, Jacinta de Fátima Rosário. "Cysteine uptake capacity is a relevant mechanism of resistance to platinum salts, in ovarian cancer". Mestrado, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2018.
  13. Ramos, Cristiano Manuel Colaço. "Role of EGF mediated laminin y2 chain in uterine cervix carcinoma". Mestrado, Fundação da Faculdade de Ciências da Universidade de Lisboa, 2017. http://hdl.handle.net/10451/30719.
  14. Silva, Fernanda Maria Gonçalves da. "Molecular mechanisms underlying the action of histone deacetylases inhibitors (HDACIs) in ovarian cancer". Doutoramento, Universidade Nova de Lisboa, 2017. http://hdl.handle.net/10362/21372.
  15. Nunes, Carolina Martins Resende Alves, 1991-. "Modulation of Acute Myeloide Leukaemis (AML) metabolism by the vascular Endothelial Growth Factor (VEGF): in vitro study". Mestrado, Fundação da Faculdade de Ciências da Universidade de Lisboa, 2014. http://hdl.handle.net/10451/12106.
  16. Serpa, Jacinta de Fátima Rosário. "How tumor cells recognize and interact with endothelial cells in primary tumor and organs target of metastasis". Doutoramento, Universidade Nova de Lisboa, 2014.
  17. Coelho, Filipa Lopes. "Gluconeogenesis and amino acids metabolism in ovarian clear cell carcinoma". Mestrado, Universidade do Algarve - Campus de Gambelas, 2013. http://hdl.handle.net/10400.1/6908.
  18. Silva, Lídia Jorge Santos, 1989-. "Metabolic switch in uterine cervix cancer: in vitro study of adenocarcinoma (HeLa) and squamous cell carcinoma (SiHa) cell lines". Mestrado, Fundação da Faculdade de Ciências da Universidade de Lisboa, 2012. http://hdl.handle.net/10451/7527.
  19. Brito, Filipa Mafalda dos Santos Aires, 1986-. "Role of monocarboxylate transporter 1 (MCT1) and lactacte dehydrogenase A chain (LDHA) in acute myeloid leukaemia (AML)". Mestrado, Fundação da Faculdade de Ciências da Universidade de Lisboa, 2012. http://hdl.handle.net/10451/7575.
  20. Fernandes, Sofia Gouveia Pereira, 1988-. "Role of fibronectin in tumor development and progression". Mestrado, Fundação da Faculdade de Ciências da Universidade de Lisboa, 2011. http://hdl.handle.net/10451/5768.
  21. Domingues, Germana Andreia Taipa Leandro. "Specific features of endothelial cells in primary tumors". Doutoramento, 2009. http://hdl.handle.net/10362/14247.
  22. Carriço, Renata Bordeira Costa. "Estudo de mutações somáticas no gene APC em doentes com cancro do cólon e recto em idade jovem". Mestrado, Fundação da Faculdade de Ciências da Universidade de Lisboa, 2008. http://catalogo.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000568465.

Propriedade Intelectual

Pedido provisório de patente
  1. 2023. "Glutaminase, Methods and Uses Thereof".
    Protegido

Outros

Outra produção
  1. Preservation of tumor architecture and heterogeneity in long-term cultures of patient-derived explants. 2018. Sofia Abreu; fernanda silva; Sara da Mata; Teresa F. Mendes; Marta Teixeira; Bruno Filipe; Sonia Morgado; et al. https://novaresearch.unl.pt/en/publications/67ce4f7e-4f34-4a04-9bab-69b348440017.
    10.1158/1538-7445.AM2018-1048
  2. Glycidamide - A carcinogenic and a cancer promoter agent - Hepatic in vitro model. 2015. C. Nunes; C. Charneira; A. Antunes; Jacinta Serpa. https://novaresearch.unl.pt/en/publications/b8e08b51-eade-4ad6-9e1c-f50fe8ed0c00.
    10.1016/j.toxlet.2015.08.1102
  3. TP53 mutation underlies the faillure of HDAC inhibitor (vorinostat) in ovarian cancer treatment. 2015. Silva, F. S.; Coelho, F; Gouveia Fernandes, S; Félix, A; Pereira, S; Serpa, Jacinta de Fátima Rosário.
  4. MONOCYTES/MACROPHAGES IN CANCER, FROM TUMOR AGGRESSORS TO VASCULAR COMPONENTS – A NEW SIGHT FOR ANTI-ANGIOGENIC THERAPY. 2015. Gouveia Fernandes, S; Domingues, G; Serpa, Jacinta de Fátima Rosário.
  5. Increased Expression of Monocarboxylate Transporters 1 and 4 Correlates with Histologic Type of Uterine Cervical Cancer. 2014. J. Ferreira; F. Silva; L. Silva; Jacinta Serpa; Ana Felix. https://novaresearch.unl.pt/en/publications/7382806a-0855-43a1-908d-a328b3495163.
  6. VORINOSTAT INDUCES ARID1A SPLICING VARIANT EXPRESSION WHICH MAY REGULATE HNF1B AND CELL SURVIVAL, IN OVARIAN CLEAR CELL CARCINOMA (CCC). 2013. F. Silva; S. Fernandes; Ana Felix; Jacinta Serpa. https://novaresearch.unl.pt/en/publications/d7bca5b5-5bfe-4348-8263-1f88a67e4aed.
  7. GLUTAMINE AND CYSTEINE CONTRIBUTE FOR OVARIAN CLEAR CELL CARCINOMA SURVIVAL (OCCC), THROUGH MTOR ACTIVATION AND GLUTATHIONE SYNTHESIS. 2013. S. Fernandes; F. Coelho; Ana Felix; Jacinta Serpa. https://novaresearch.unl.pt/en/publications/916db210-8d6a-4fa7-8cf5-ad21dd7ed045.
  8. PRODUCTION AND CONSUMPTION OF LACTATE IS RELATED TO THE HISTOLOGICAL TYPE IN UTERINE CERVIX CARCINOMAS. 2013. L. Silva; F. Brito; F. Silva; L. Neto; Luis G Goncalves; V. Maximo; S. Dias; Ana Felix; Jacinta Serpa. https://novaresearch.unl.pt/en/publications/d111158c-f985-4dad-8532-c45a2c81dc60.
  9. Monocarboxylate transporters (MCTs) and lactate dehydrogenases (LDHs) as putative therapeutic targets in acute myeloid leukaemia (AML) Role of microenvironment in the metabolic switch.. 2011. Jacinta Serpa; Germana Domingues; Paula Gameiro; Maria Gomes da Silva; Sergio Dias. https://novaresearch.unl.pt/en/publications/15de74be-09cd-465e-bc71-4fac3b995ee5.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2012 HDACS INHIBITORS EFFECTS IN OVARIAN CLEAR CELL CARCINOMA Sinal 2012
(Póvoa do Varzim, Portugal)
2003 Characterization and regulation of the 5’-flanking region of human MUC2 in gastric carcinoma cell lines Mucins in Health and Disease – 7th International Workshop on Carcinoma-associated mucins
(Creta, Grécia)
2003 Modifications in the mucin expression profile in gastric carcinoma and intestinal metaplasia Mucins in Health and Disease – 7th International Workshop on Carcinoma-associated mucins
(Creta, Grécia)
2001 Mucins: differentiation markers in intestinal metaplasia and gastric carcinoma X Porto Cancer Meeting - Diagnosis of cancerous and precancerous lesions
(Porto, Portugal)
2000 Expression of the recombinant Human alpha 3/4-Fucosyltransferase III using the baculovirus insect cell system. Enzyme characterisation and substrate specificity. Congresso Nacional de Bioquímica
(Póvoa do Varzim, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021/02/01 - Atual Dendrimer nanotherapeutics: A novel anticancer task force
Coorientador
Associação para o Desenvolvimento do Instituto Superior Técnico, Portugal
2020/09/01 - Atual Targeting glutamine availability- a new strategy to treat malignant gliomas
Orientador
 Biomedicina (Doutoramento)
Universidade Nova de Lisboa, Portugal
2019 - Atual Cysteine availability rules thiols’ turnover and breast cancer chemoresistance
Orientador
 PhD (Doutoramento)
Universidade Nova de Lisboa, Portugal
2019 - Atual MCT1 a peon in metabolic adaptation and a crucial target in lung cancer
Orientador
 PhD (Doutoramento)
Universidade Nova de Lisboa, Portugal
2019 - Atual Tackling cancer chemoresistance by metabolic remodeling
Orientador
 PhD (Doutoramento)
Universidade Nova de Lisboa, Portugal
2017 - Atual Monocytes as neoangiogenesis promoters and anti-cancer targets
Orientador
 PhD (Doutoramento)
Universidade Nova de Lisboa, Portugal
2017/01/01 - 2021/04/21 Novel mechanisms in angiogenesis: oxidative stress as a promoter of monocyte-to-endothelial cell differentiation and endothelial cell activation
Orientador
 ProRegeM (Doutoramento)
Universidade Nova de Lisboa Comprehensive Health Research Centre, Portugal
2012 - 2019/09/30 Male breast cancer
Coorientador
 PhD (Doutoramento)
Universidade Nova de Lisboa, Portugal
2015 - 2019/04/02 Cysteine degradation as a sulfur source to sustain oxidative phosphorylation (OXPHOS) in hypoxic cancer cells - new therapeutic targets
Orientador
 PhD (Doutoramento)
Universidade Nova de Lisboa, Portugal
2018 - 2019 Metabolic remodeling of endothelial cells upon hypoxia
Orientador
 Mestrado (Mestrado)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2018 - 2019 Cysteine metabolism and pancreatic Neuroendocrine Tumours (PNETs) chemoresistance
Orientador
 mestrado (Mestrado)
Universidade Nova de Lisboa, Portugal
2018 - 2019 xCT (SLC7A11)-Antiporter system role in ovarian carcinoma chemoresistance
Orientador
 mestrado (Mestrado)
Università di Pisa Sistema Bibliotecario di Ateneo, Itália
2017 - 2018 Disclosing FATP1 as a therapeutic target in breast cancer.
Orientador
 mestrado (Mestrado)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2017 - 2018 Cysteine uptake capacity is a relevant mechanism of resistance to platinum salts, in ovarian cancer
Orientador
 mestrado (Mestrado)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - 2017 Clarification of ¿2 laminin role in cervical invasive carcinoma- a putative biomarker for disease outcome
Orientador
 mestrado (Mestrado)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2009 - 2017 Biomarkers of sensitivity / resistance to new therapeutic targets: the use of histone deacetylases inhibitors in ovarian cancer
Coorientador
 PhD (Doutoramento)
2013 - 2014 Modulation of Acute Myeloide Leukemia (AML) metabolism by the Vascular Endothelial Growth Factor (VEGF)- in vitro study
Orientador
 mestrado (Mestrado)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2010 - 2014 How tumor cells recognize and interact with endothelial cells in primary tumor and organs target of metastasis
Coorientador
 PhD (Doutoramento)
Universidade Nova de Lisboa, Portugal
2013 - 2013 Gluconeogenesis and amino acids metabolism in ovarian clear cell carcinoma
Orientador
 MsC (Mestrado)
Universidade do Algarve, Portugal
2012 - 2012 Specific features of endothelial cells in primary tumors
Coorientador
 PhD (Doutoramento)
Universidade Nova de Lisboa, Portugal
2012 - 2012 Lactate dehydrogenase A chain (LDHA) in Acute Myeloid Leukaemia (AML)
Orientador
 MsC (Mestrado)
Universidade de Lisboa, Portugal
2011 - 2012 Metabolic switch in uterine cervix cancer - in vitro study of adenocarcinoma (HeLa) and squamous cell carcinoma (SiHa) cell lines
Orientador
 mestrado (Mestrado)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2011 - 2011 Role of fibronectin (FN) in tumour development and progression
Orientador
 MsC (Mestrado)
Universidade de Lisboa, Portugal
2008 - 2008 Regulação da expressão de "Vascular endothelial growth factor" (VEGF) e do seu receptor 2 (KDR). Modificações pós-traducionais de KDR
Orientador
 MsC (Mestrado)
Universidade de Lisboa, Portugal
2007 - 2007 Estudo de mutações somáticas no gene APC em doentes com cancro de colón e recto em idade jovem
Orientador
 MsC (Mestrado)
Universidade de Lisboa, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2013 - 2013 VORINOSTAT INDUCES ARID1A SPLICING VARIANT EXPRESSION WHICH MAY REGULATE HNF1? AND CELL SURVIVAL, IN OVARIAN CLEAR CELL CARCINOMA (CCC)
Congresso
 ESGO 2013
2013 - 2013 GLUTAMINE AND CYSTEINE CONTRIBUTE FOR OVARIAN CLEAR CELL CARCINOMA SURVIVAL (OCCC), THROUGH mTOR ACTIVATION AND GLUTATHIONE SYNTHESIS
Congresso
 ESGO 2013
2013 - 2013 PRODUCTION AND CONSUMPTION OF LACTATE IS RELATED TO THE HISTOLOGICAL TYPE IN UTERINE CERVIX CARCINOMAS
Congresso
 ESGO 2013
2013 - 2013 ROLE OF SODIUM LACTATE (NALAC), C-MYC AND STAT3 IN THE METABOLIC SWITCH IN UTERINE CERVIX CARCINOMAS
Congresso
 Porto Cancer Meeting 2013
2012 - 2012 Role of sodium lactate (NaLac), EGF and c-Myc in the expression of Monocarboxylated Transporter 1 (MCT1) in uterine cervix cancer.
Congresso
 EACR one-day-meeting sponsored by Carlos Caldas
2012 - 2012 Fibronectin overexpression is associated to a more aggressive phenotype- in vitro and in vivo colon cancer models
Congresso
 EACR one-day-meeting sponsored by Carlos Caldas
2011 - 2011 Monocarboxylate transporters (MCTs) and lactate dehydrogenases (LDHs) as putative therapeutic targets in acute myeloid leukaemia (AML)
Congresso
 Experimental Biology 2011
2011 - 2011 Metabolic adaptation of uterine cervix cancer cells- in vitro and in vivo models (2011).
Congresso
 TUMIC meeting
2010 - 2010 Role of VEGF signalling in the regulation of KDR expression, in endothelial and tumoural microenvironment
Congresso
 16th International Charles Heidelberger Symposium on Cancer Research
2010 - 2010 CELL DEATH INDUCED BY HDACS INHIBITORS IN OVARIAN CANCER CELL LINES (SEROUS AND CLEAR CELL CARCINOMAS) - ROLE OF NOTCH, TP53 AND FN1
Congresso
 16th International Charles Heidelberger Symposium on Cancer Research
2009 - 2009 Colon cancer cells that metabolise butyrte acquire EMT phenotypes including increased tumour growth, angiogenesis and metastasis
Congresso
 Metastasis Summer School, Sesimbra, Portugal and Fifth international conference on tumor microenvironment: progression, therapy, and prevention
2008 - 2008 Butyric acid induces a more aggressive phenotype in HCT15 colon cancer cells, in vitro and in vivo studies.
Congresso
 12ª reunião da Sociedade Portuguesa de Genética Humana
2007 - 2007 Butyric acid treatment of resistant colon cancer cells promotes the acquisition of a more angiogenic phenotype
Congresso
 ELSO 2007
2005 - 2005 Overexpression of Lea and Lewis enzyme in gastric cancer cell lines and in gastric tissues is related to DNA hypomethylation
Congresso
 96th AACR-2005
2004 - 2004 Two new FUT2 missense polymorphisms, 739G>A and 839T>C, are partly responsible for non-secretor status in a Caucasian population from Northern Portugal
Congresso
 EACR-18.
2004 - 2004 Two new FUT2 missense polymorphisms, 739G>A and 839T>C, are partly responsible for non-secretor status in a Caucasian population from Northern Portugal
Congresso
 GlycoT 2004
2003 - 2003 Regulation of expression of alpha-1,4 fucosyltransferases (FUT3 and FUT5) and Lewis antigens by promoter methylation in gastric carcinoma cell lines.
Congresso
 Mucins in Health and Disease – 7th International Workshop on Carcinoma-associated mucins
2002 - 2002 Polymorphisms of Lewis enzyme (alpha 1-3/4 fucosyltransferase) and study of its relationship with Helicobacter pylori infection in a portuguese population
Congresso
 Congresso ELSO (European Life Scientist Organization)
2000 - 2000 Biosynthetic pathway of type 1 chain Lewis antigens in MUC5AC and MUC2 expressing cells of intestinal metaplasia
Congresso
 EU Consortium Meeting - Mucins in the pathophysiology of inflammatory diseases of the respiratory and digestive tract
1999 - 1999 Deteccção de dsRNA de vírus delevedura utilizando uma biblioteca de péptidos expressa em fagos
Congresso
 National Congress of Microbiology- Micro 99
1998 - 1998 Construction of a Vaccinium myrtillus cDNA library and screening for exoperoxidases genes
Congresso
 National Congress of Biochemistry
1998 - 1998 Selection of phage-peptides with affinity for dsRNA from a 15-MER phage display peptide library
Congresso
 National Congress of Biochemistry
1998 - 1998 Production of recombinant antibodies against dsRNA
Congresso
 National Congress of Biochemistry
Distinções

Outra distinção

2008 Prémio BLPCC (Bolsa da Liga Portuguesa Contra o Cancro)
Liga Portuguesa Contra o Cancro, Portugal