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I have always been interested in how the tight control of the molecular processes of a cell are needed for the correct function of an organism and how their deregulation can lead to pathologies. Thus, I studied a BSc in Biology (Universidade do Porto) and later a MSc in Molecular Genetics (Universidade do Minho). Given my early interest in research, I decided to complete my training through gaining hands-on experience in different laboratories, including the laboratories of Dr. Teixeira and Dr. Preto during my BSc and MSc thesis in Portugal, and later on at the laboratories of Dr. Clarke at the MRC (United Kingdom) and Dr. Fidalgo at CIMUS (Spain) abroad. As a result of my contributions to several research projects of these labs, I am the co-author of 8 articles, including a first-author paper in the European Journal of Medical Chemistry. During these years, I have also attended several national and international conferences where I have been able to present my work to peer researchers, allowing me to become more visible in the field. Given my personal interests and previous experiences, I found a unique niche of research at the Center of Molecular Medicine and Chronic Diseases (CIMUS), at the University of Santiago de Compostela (USC) in Spain, to do my PhD under the supervision of Dr. Fidalgo and Dr. Guallar. These two research groups happen to unite the aspects of research which are more appealing to me: Epitranscriptomics, ageing and obesity. Being granted with a competitive FCT 2021 PhD Studentship will be definitive to push forward my long-term career goal, which is to become an independent researcher in Portugal in the exciting field of RNA modifications in the context of public health challenges such as obesity and ageing.
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Identificação

Identificação pessoal

Nome completo
Tiago Moreira
Data de nascimento
1993/12/17
Género
Masculino

Nomes de citação

  • Moreira, Tiago

Identificadores de autor

Ciência ID
3118-8F87-B8B7
ORCID iD
0000-0003-3817-7103

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador independente (B2) Utilizador proficiente (C1)
Formação
Grau Classificação
2020/10 - 2024/08/31
Em curso
 Medicina Molecular (Doutoramento)
Universidade de Santiago de Compostela, Espanha
2014/10 - 2016/12/07
Concluído
 Genética Molecular (Mestrado)
Universidade do Minho Escola de Ciências, Portugal
"Unravelling the anticancer effects of multifunctional polymer-ruthenium conjugates" (TESE/DISSERTAÇÃO)
 18
2011/10 - 2014/06/28
Concluído
 Biologia (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Evaluating the effects of acetophenone in the expression and activity of glutamine synthetase in Solanum nigrum L." (TESE/DISSERTAÇÃO)
 15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/05 - 2020/09 Assistente de Investigação (carreira) (Investigação) Universidade de Santiago de Compostela, Espanha
Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, Espanha
2017/02 - 2017/11 Estagiário de Investigação (Investigação) Manchester Cancer Research Centre, Reino Unido
Manchester Cancer Research Centre, Reino Unido
2015/09 - 2016/10 Estagiário de Investigação (Investigação) Universidade do Minho Escola de Ciências, Portugal
Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2013/09 - 2014/06 Estagiário de Investigação (Investigação) Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Faculdade de Ciências, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/05 - Atual Member of the research group: Molecular Mechanisms of Disease (Mecanismos Moleculares de la Enfermedad - MeMoEN) Universidade de Santiago de Compostela, Espanha
Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, Espanha
Produções

Publicações

Artigo em revista
  1. Guallar, Diana; Fuentes-Iglesias, Alejandro; Souto, Yara; Ameneiro, Cristina; Freire-Agulleiro, Oscar; Pardavila, Jose Angel; Escudero, Adriana; et al. "ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress". Cell Stem Cell 27 2 (2020): 300-314.e11. http://dx.doi.org/10.1016/j.stem.2020.04.016.
    10.1016/j.stem.2020.04.016
  2. Simões, Bruno M.; Santiago-Gómez, Angélica; Chiodo, Chiara; Moreira, Tiago; Conole, Daniel; Lovell, Scott; Alferez, Denis; et al. "Targeting STAT3 signaling using stabilised sulforaphane (SFX-01) inhibits endocrine resistant stem-like cells in ER-positive breast cancer". Oncogene 39 25 (2020): 4896-4908. http://dx.doi.org/10.1038/s41388-020-1335-z.
    10.1038/s41388-020-1335-z
  3. Ameneiro, Cristina; Moreira, Tiago; Fuentes-Iglesias, Alejandro; Coego, Alba; Garcia-Outeiral, Vera; Escudero, Adriana; Torrecilla, Daniel; et al. "BMAL1 coordinates energy metabolism and differentiation of pluripotent stem cells". Life Science Alliance 3 5 (2020): e201900534. http://dx.doi.org/10.26508/lsa.201900534.
    10.26508/lsa.201900534
  4. Moreira, Tiago; Francisco, Rita; Comsa, Elisabeta; Duban-Deweer, Sophie; Labas, Valérie; Teixeira-Gomes, Ana-Paula; Combes-Soia, Lucie; et al. "Polymer “ruthenium-cyclopentadienyl” conjugates - New emerging anti-cancer drugs". European Journal of Medicinal Chemistry 168 (2019): 373-384. http://dx.doi.org/10.1016/j.ejmech.2019.02.061.
    10.1016/j.ejmech.2019.02.061
  5. Moreira, José Tiago; Moreira, Tiago M.; Cunha, João B.; Azenha, Manuel; Fidalgo, Fernanda; Teixeira, Jorge. "Differential effects of acetophenone on shoots' and roots' metabolism of Solanum nigrum L. plants and implications in its phytoremediation". Plant Physiology and Biochemistry 130 (2018): 391-398. http://dx.doi.org/10.1016/j.plaphy.2018.07.027.
    10.1016/j.plaphy.2018.07.027
  6. Teixeira, Ricardo G.; Brás, Ana Rita; Côrte-Real, Leonor; Tatikonda, Rajendhraprasad; Sanches, Anabela; Robalo, M. Paula; Avecilla, Fernando; et al. "Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells". European Journal of Medicinal Chemistry 143 (2018): 503-514. http://dx.doi.org/10.1016/j.ejmech.2017.11.059.
    10.1016/j.ejmech.2017.11.059
  7. Matos, António; Marques, Fernanda; Francisco, Rita; Moreira, Tiago; Preto, Ana; Garcia, M. Helena; Valente, Andreia. "Unraveling the mode of action of new promising polymer–ruthenium conjugates". Ultrastructural Pathology 41 1 (2017): 129-130. http://dx.doi.org/10.1080/01913123.2016.1272669.
    10.1080/01913123.2016.1272669
Capítulo de livro
  1. Cazzanelli, Giulia; Moreira, Tiago; Ferro, Suellen; Azevedo-Silva, João; Nogueira, Eugénia; Preto, Ana. "Colorectal Cancer Therapeutic Approaches: From Classical Drugs to New Nanoparticles". In Frontiers in Anti-Cancer Drug Discovery, 93-173. BENTHAM SCIENCE PUBLISHERS, 2016.
    10.2174/9781681082516116070004
Atividades

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2020/11/18 - 2020/11/20 Co-author of the following oral presentation: "RNA editing is required for mesenchymal-to-epithelial transition during somatic cell reprogramming". Authors: Diana Guallar, Alejandro Fuentes-Iglesias, Cristina Ameneiro, Yara Souto, Adriana Escudero, Vera Garcia-Outeiral, Jose Angel Pardavila, Tiago Moreira, Daniel Torrecilla, Carl R. Walkley, Jianlong Wang & Miguel Fidalgo. 17th Spanish Society for Developmental Biology Meeting
Spanish Society for Developmental Biology (SEBD), Espanha
2020/09/30 - 2020/10/02 Co-author of the following oral communication: "ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress". Authors: Alejandro Fuentes-Iglesias, Diana Guallar,Yara Souto, Cristina Ameneiro, Jose Angel Pardavila, Adriana Escudero, Vera Garcia-Outeiral, Tiago Moreira, Daniel Torrecilla, Carl Walkley, Jianlong Wang, Miguel Fidalgo.
Conferência
 RNA Editing and Modifications: From Biology to Therapy
Keystone Symposia, Estados Unidos
2020/09/22 - 2020/09/25 Co-author of the following oral presentation: "Loss of A-to-I RNA editing impairs cellular rejuvenation through somatic cell reprogramming by aberrant activation of endoplasmic reticulum stress". Authors: Diana Guallar, Alejandro Fuentes-Iglesias, Cristina Ameneiro, Yara Souto, Adriana Escudero, Vera Garcia-Outeiral, Jose Angel Pardavila, Tiago Moreira, Cristina De La Parte, Daniel Torrecilla, Carl R. Walkley, Jianlong Wang, Miguel Fidalgo.
Conferência
 Mechanisms of Aging
Cold Spring Harbor Laboratory, Estados Unidos
2019/11/19 - 2019/11/20 Co-author of the following poster: "Circadian clock independent functions of BMAL 1 in regulation of pluripotent stem cells differentiation". Authors: Cristina Ameneiro, Tiago Moreira, Alba Coego, Vera Garcia-Outeiral, Adriana Escudero, Alejandro Fuentes-Iglesias, Daniel Torrecilla, Miguel Fidalgo, Diana Guallar
Conferência
 12th Guangzhou International Stem Cell Meeting
Guangzhou Institutes of Biomedicine and Health, China
2019/11/19 - 2019/11/20 Co-author of the following poster: "ADAR1 catalytic activity is required for mesenchymal-to-epithelial transition during somatic cell reprogramming". Authors: Diana Guallar, Alejandro Fuentes-Iglesias, Yara Souto, Oscar Freire-Agullero, Carmen Saenz, Adriana Escudero, Cristina Ameneiro, Vera Garcia, Hen Xiong, Jose Angel Pardavila, Tiago Moreira, Dongbing Liu, Shidi Xiao, Yong Hou, Kui Wu, Jochen C. Hartner, Leo J Lee, Miguel G. Blanco, Miguel López, Carl R. Walkley, Jianlong Wang, Miguel Fidalgo.
Conferência
 The 12th Guangzhou International Conference on Stem Cell and Regenerative Medicine
Guangzhou Institutes of Biomedicine and Health, China
2018/01/15 - 2018/01/16 Co-author of the following poster: "SFX-01 targets STAT3 signalling to inhibit stem-like cells in breast cancer patient derived xenograft tumours". Authors: Bruno Simões, Tiago Moreira, Denis Alferez, Rachel Eyre, Kath Spence, Angélica Santiago-Gómez, Aida Sarmiento-Castro, Andy Sims, Elisabetta Marangoni, Sacha Howell, Robert Clarke
Conferência
 1st UK Interdisciplinary Breast Cancer Symposium
Breast Cancer Now, Reino Unido
2016/12/08 - 2016/12/10 First author of the following poster: "Multifunctional polymer ruthenium conjugates as new promising anticancer agents". Authors: Tiago Moreira, Rita Francisco, M. Helena Garcia, Andreia Valente, Ana Preto
Congresso
 XIX Congresso Nacional de Bioquimica
Sociedade Portuguesa de Bioquímica, Portugal
2016/04/28 - 2016/04/29 First author of the following poster: "Exploring the anticancer effects of multifunctional polymer ruthenium conjugates: new promising anticancer agents". Authors: Tiago Moreira, Anabela Sanchez, Adhan Pilon, Rita Francisco, Alexandra Ferreira, M. Helena Garcia, Ana Preto, Andreia Valente
Congresso
 2º Congresso Internacional da Associação Portuguesa de Investigação em Cancro
Associação Portuguesa de Investigação em Cancro, Portugal

Membro de associação

Nome da associação Tipo de participação
2018/05 - Atual Molecular Mechanisms of Disease (Mecanismos Moleculares de la Enfermedad, MeMoEN) is a research group that integrates laboratories of the Universidade de Santiago de Compostela that are focused on the biomedical research of the molecular mechanisms of disease. The main lines of research of the group comprise: molecular mechanisms of cancer, stem cells research, DNA repair and genome integrity, cell response to stress, nanomedicine, among others. Training Researcher