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Identificação

Identificação pessoal

Nome completo
Rui Filipe Duarte da Silva

Nomes de citação

  • Silva, Rui D

Identificadores de autor

Ciência ID
4616-48C1-AB64
ORCID iD
0000-0003-2168-8599
Google Scholar ID
6YrcX6YAAAAJ&hl
Researcher Id
C-5622-2012
Scopus Author Id
15045741700

Endereços de correio eletrónico

  • rfsilva@ualg.pt (Profissional)

Moradas

  • Faculty of Medicine and Biomedical Sciences, University of Algarve, Campus de Gambelas, Bld. 2 Lab. 3.64, 8005-139, Faro, Faro, Portugal (Profissional)
Formação
Grau Classificação
2006/03/01 - 2011/07/01
Concluído
 PhD in Biological Sciences (Doutoramento)
Universidade do Minho, Portugal
"Yeast as a model system for the study of Bax regulation by protein kinase C isoforms" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2018/10/24 - Atual Investigador Contratado (Investigação) Universidade do Algarve, Portugal
Universidade do Algarve Algarve Biomedical Center Research Institute, Portugal
Produções

Publicações

Artigo em revista
  1. Varland, Sylvia; Silva, Rui D; Kjosås, Ine; Faustino, Alexandra; Bogaert, Annelies; Billmann, Maximilian; Boukhatmi, Hadi; et al. Autor correspondente: Silva, Rui D. "N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity". Nature Communications 14 1 (2023): http://dx.doi.org/10.1038/s41467-023-42342-y.
    Acesso aberto • Publicado • 10.1038/s41467-023-42342-y
  2. Carmo, Catarina; Coelho, João; Silva, Rui D; Tavares, Alexandra; Boavida, Ana; Gaetani, Paola; Guilgur, Leonardo G; Martinho, Rui Gonçalo; Oliveira, Raquel A. "A dual-function SNF2 protein drives chromatid resolution and nascent transcript removal in mitosis". EMBO reports 24 9 (2023): http://dx.doi.org/10.15252/embr.202256463.
    10.15252/embr.202256463
  3. Feijão, Tália; Marques, Bruno; Silva, Rui D.; Carvalho, Célia; Sobral, Daniel; Matos, Ricardo; Tan, Tian; et al. "Polycomb group (PcG) proteins prevent the assembly of abnormal synaptonemal complex structures during meiosis". Proceedings of the National Academy of Sciences 119 42 (2022): http://dx.doi.org/10.1073/pnas.2204701119.
    Publicado • 10.1073/pnas.2204701119
  4. Rathore, Om Singh; Silva, Rui D.; Ascensão-Ferreira, Mariana; Matos, Ricardo; Carvalho, Célia; Marques, Bruno; Tiago, Margarida N.; et al. "NineTeen Complex-subunit Salsa is required for efficient splicing of a subset of introns and dorsal–ventral patterning". RNA 26 12 (2020): 1935-1956. http://dx.doi.org/10.1261/rna.077446.120.
    10.1261/rna.077446.120
  5. Silva, Rui D.; Mirkovic, Mihailo; Guilgur, Leonardo G.; Rathore, Om S.; Martinho, Rui Gonçalo; Oliveira, Raquel A.. "Absence of the Spindle Assembly Checkpoint Restores Mitotic Fidelity upon Loss of Sister Chromatid Cohesion". Current Biology 28 17 (2018): 2837-2844.e3. http://dx.doi.org/10.1016/j.cub.2018.06.062.
    10.1016/j.cub.2018.06.062
  6. Alves, S.; Neiri, L.; Chaves, S.R.; Vieira, S.; Trindade, D.; Manon, S.; Dominguez, V.; et al. "N-terminal acetylation modulates Bax targeting to mitochondria". International Journal of Biochemistry and Cell Biology 95 (2018): 35-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-85038257457&partnerID=MN8TOARS.
    10.1016/j.biocel.2017.12.004
  7. Ribeiro, A.L.; Silva, R.D.; Foyn, H.; Tiago, M.N.; Rathore, O.S.; Arnesen, T.; Martinho, R.G.. "Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85007014446&partnerID=MN8TOARS.
    10.1038/srep39118
  8. Silva, R.D.; Martinho, R.G.. "Developmental roles of protein N-terminal acetylation". Proteomics 15 14 (2015): 2402-2409. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006355201&partnerID=MN8TOARS.
    10.1002/pmic.201400631
  9. Rodrigues, J.; Silva, R.D.; Noronha, H.; Pedras, A.; Gerós, H.; Côrte-Real, M.. "Flow cytometry as a novel tool for structural and functional characterization of isolated yeast vacuoles". Microbiology (United Kingdom) 159 PART 5 (2013): 848-856. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876924489&partnerID=MN8TOARS.
    10.1099/mic.0.062570-0
  10. Silva, R.D.; Saraiva, L.; Coutinho, I.; Gonçalves, J.; Côrte-Real, M.. "Yeast as a powerful model system for the study of apoptosis regulation by protein kinase C isoforms". Current Pharmaceutical Design 18 17 (2012): 2492-2500. http://www.scopus.com/inward/record.url?eid=2-s2.0-84860467702&partnerID=MN8TOARS.
  11. Vilela-Moura, A.; Schuller, D.; Mendes-Faia, A.; Silva, R.D.; Chaves, S.R.; Sousa, M.J.; Côrte-Real, M.. "The impact of acetate metabolism on yeast fermentative performance and wine quality: Reduction of volatile acidity of grape musts and wines". Applied Microbiology and Biotechnology 89 2 (2011): 271-280. http://www.scopus.com/inward/record.url?eid=2-s2.0-78651067361&partnerID=MN8TOARS.
    10.1007/s00253-010-2898-3
  12. Silva, R.D.; Manon, S.; Gonçalves, J.; Saraiva, L.; Côrte-Real, M.. "Modulation of Bax mitochondrial insertion and induced cell death in yeast by mammalian protein kinase Ca". Experimental Cell Research 317 6 (2011): 781-790. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952191234&partnerID=MN8TOARS.
    10.1016/j.yexcr.2010.12.001
  13. Silva, R.D.; Manon, S.; Gonçalves, J.; Saraiva, L.; Côrte-Real, M.. "The importance of humanized yeast to better understand the role of Bcl-2 family in apoptosis: Finding of novel therapeutic opportunities". Current Pharmaceutical Design 17 3 (2011): 246-255. http://www.scopus.com/inward/record.url?eid=2-s2.0-79958219652&partnerID=MN8TOARS.
    10.2174/138161211795049651
  14. Fontes, N.; Silva, R.; Vignault, C.; Lecourieux, F.; Gerás, H.; Delrot, S.. "Purification and functional characterization of protoplasts and intact vacuoles from grape cells". BMC Research Notes 3 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77949536638&partnerID=MN8TOARS.
    10.1186/1756-0500-3-19
  15. Almeida, T.; Marques, M.; Mojzita, D.; Amorim, M.A.; Silva, R.D.; Almeida, B.; Rodrigues, P.; et al. "Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis". Molecular Biology of the Cell 19 3 (2008): 865-876. http://www.scopus.com/inward/record.url?eid=2-s2.0-41649101223&partnerID=MN8TOARS.
    10.1091/mbc.E07-06-0604
  16. Pereira, C.; Silva, R.D.; Saraiva, L.; Johansson, B.; Sousa, M.J.; Côrte-Real, M.. "Mitochondria-dependent apoptosis in yeast". Biochimica et Biophysica Acta - Molecular Cell Research 1783 7 (2008): 1286-1302. http://www.scopus.com/inward/record.url?eid=2-s2.0-45049085090&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2008.03.010
  17. Saraiva, L.; Silva, R.D.; Pereira, G.; Gonçalves, J.; Côrte-Real, M.. "Specific modulation of apoptosis and Bcl-xL phosphorylation in yeast by distinct mammalian protein kinase C isoforms". Journal of Cell Science 119 15 (2006): 3171-3181. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748290027&partnerID=MN8TOARS.
    10.1242/jcs.03033
  18. Silva, R.D.; Sotoca, R.; Johansson, B.; Ludovico, P.; Sansonetty, F.; Silva, M.T.; Peinado, J.M.; Côrte-Real, M.. "Hyperosmotic stress induces metacaspase- and mitochondria-dependent apoptosis in Saccharomyces cerevisiae". Molecular Microbiology 58 3 (2005): 824-834. http://www.scopus.com/inward/record.url?eid=2-s2.0-27444438569&partnerID=MN8TOARS.
    10.1111/j.1365-2958.2005.04868.x
Resumo em conferência
  1. Silva, Rui. "Saccharomyces cerevisiae commits to programmed cell death in response to hyperosmotic stress caused by glucose". Trabalho apresentado em CYTOMETRY PART A, 2004.
    Publicado