João Pedro Oliveira da Silva Paulino Lopes (5E1A-A059-E017)

Curriculum Vitae

João Pedro Oliveira da Silva Paulino Lopes

João Lopes holds a Cell Biology PhD obtained in 2009 from University of Coimbra (Portugal), a 5-star QS Star Rating university, where he also graduated in Biology in 2003. During the PhD he was a visiting researcher at the University of California (Irvine, USA), under the supervision of Prof. Frank LaFerla, a world's top 2% most-cited scientist. In his PhD, João Lopes made important contributions to the study of Alzheimer's disease (AD) and Prion encephalopathies (PRE), being the first to uncover the role of cyclin-dependent kinase 5 on the hyperphosphorylation of tau, triggering of apoptosis and abortive cell cycle re-entry that occur analogously in the neurodegeneration associated to both disorders. Building on the acquired expertise, in 2010 he joined the D3- Drug Discovery and Development department at the Italian Institute of Technology (IIT, Genova, Italy), a top-50 research institution in Europe, as a post-doctoral researcher. At IIT, João Lopes explored the pharmacology behind the neuroprotective potential of two major anti-AD drugs, memantine and galantamine. Furthermore, he was part of the team involved in the development and testing of memoquin, a multi-target compound against AD. In 2012 he returned to Portugal and joined the Neuromodulation group (CNC/CIBB, Coimbra, Portugal), a leading group worldwide in the study of purinergic signaling in brain diseases headed by Prof. Rodrigo Cunha, another top 2% most cited scientist. First as a post-doc (supported by an FCT fellowship), from 2019 to 2023 hired as a Junior Researcher and presently as an Auxiliary Researcher (FCT’s 5th CEEC), he developed experimental work focused on the modulation of adenosine receptor activity as a neuroprotective mechanism against AD, although he also was involved in projects that addressed Parkinson's disease, Angelman syndrome and other brain disorders. João Lopes published 29 papers in international peer-reviewed journals (18 since 2018), and 2 book chapters. His h-index is 15, with the internationally refereed papers accumulating an impact factor of 141.7 and approximately 900 citations. João Lopes is 1st or corresponding author of 11 articles and senior author of 6 (5 within the last 2 years). Furthermore, over 80% of the publications were in journals within the first Quartile of their categories. From 2008 to 2009 he was Associate Editor of Journal of Alzheimer's Disease and is regularly invited as a reviewer by several high-impact international journals. His work has also been recognized through invited and selected oral presentations, having participated in international and national meetings both with oral and poster presentations. João Lopes supervised 1 graduation and 1 Master student and is currently the supervisor of a Master student and was tutor to several Medicine students (GAPI program). Since 2015 he lectured 9 classes to Master students at UC. João Lopes was the recipient of 2 FCT Fellowships (PhD Fellowship from 2005 to 2008 and Postdoc Fellowship from 2013 to 2019) and received 6 travel grants to participate in international meetings. He is accredited by DGAV as Coordinating Researcher (procedure and project design) for animal experimentation and has expertise in in vitro, ex-vivo and in vivo work, being proficient in electrophysiology, optogenetics, behavioral assessment, stereotaxic and peripheral administration of compounds, neuronal cell culture, cell viability assays, western blot, ELISA, immunocyto and immunohistochemistry, confocal and fluorescence microscopy, neuronal transfection, DNA and RNA extraction, PCR and agarose gel electrophoresis. His scientific areas of expertise are Adenosine research, Neurodegeneration, AD, Synaptic transmission and plasticity, Brain disorders and Pharmacology. Finally, it should be noted that his scientific activity was interrupted due to paternity in 2016 and 2018/19. Also, as consequence of a full proto-colectomy in July 2020 he was attributed a 60% disability quota.

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Identificação

Identificação pessoal

Nome completo: João Pedro Oliveira da Silva Paulino Lopes

Nomes de citação

Lopes, João P.

Identificadores de autor

Ciência ID: 5E1A-A059-E017
ORCID iD: 0000-0002-5122-1802

Moradas

Centro de Neurociências e Biologia Celular. Departamento de Zoologia, Universidade de Coimbra, 3004-517, Coimbra, Coimbra, Portugal (Profissional)
Rua da Quinta, nº 25, 1º, 3130-080, Granja do Ulmeiro, Soure, Portugal (Pessoal)

Domínios de atuação

Ciências Médicas e da Saúde - Ciências da Saúde
Ciências Médicas e da Saúde - Ciências da Saúde
Ciências Naturais - Ciências Biológicas - Biologia Celular

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Italiano	Utilizador proficiente (C1)	Utilizador independente (B1)	Utilizador elementar (A2)	Utilizador proficiente (C2)	Utilizador elementar (A2)
Francês	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador independente (B1)	Utilizador proficiente (C1)	Utilizador elementar (A2)
Espanhol; Castelhano	Utilizador proficiente (C1)	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador proficiente (C1)	Utilizador elementar (A2)

Formação

	Grau	Classificação
2012/05/01 - 2019/02/04 Concluído	Post-doctorate in Health Sciences (Pós-doutoramento) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/09/23 - 2013/10/04 Concluído	Course in Laboratory Animal Science (Outros) Especialização em Category C Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal	Approved
2010/03/01 - 2012/04/30 Concluído	Post-doctorate in Pharmacology (Pós-doutoramento) Istituto Italiano di Tecnologia, Itália
2005/01/01 - 2009/11/13 Concluído	Biology (Doutoramento) Especialização em Cell Biology Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Neurodegenerescência em Doença de Alzheimer e Encefalopatias Associadadas a Priões: Papel da Cinase Dependente de Ciclina 5 e dos Reguladores do Ciclo Celular" (TESE/DISSERTAÇÃO)	Aprovado com louvor e distinção por unanimidade
2003/10/01 - 2004/12/31 Concluído	Cell Biology (Curso de mestrado (conclusão do curso de especialização)) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal	19
1998/09/01 - 2003/07/03 Concluído	Biology (Licenciatura) Especialização em Scientific branch Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal	15

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2023/07/31 - Atual	Investigador Auxiliar (carreira) (Investigação)	Universidade de Coimbra, Portugal
	Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2019/02/05 - 2023/07/30	Investigador Contratado (Investigação)	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

2012/06/01 - 2019/02/04	Pós-doutorado (Investigação)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2010/03/01 - 2012/04/30	Investigador Contratado (Investigação)	Istituto Italiano di Tecnologia, Itália
	Istituto Italiano di Tecnologia, Itália
2006/10/02 - 2007/04/04	Investigador visitante (Investigação)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
	University of California Irvine Institute for Memory Impairments and Neurological Disorders, Estados Unidos

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2005/01/01 - 2009/11/13	PhD (Research)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2003/10/01 - 2004/12/31	MSc (Research)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
	Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Projetos

Bolsa

	Designação	Financiadores
2018/05/01 - Atual	Strategies for healthy aging CENTRO-01-0246-FEDER-000010 Investigador Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Em curso
2018 - Atual	Adenosine A2A receptors as a new opportunity to manage and detail the neurobiology of emotional distress Fundacion LaCaixa Investigador Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação para a Ciência e a Tecnologia Fundación La Caixa Em curso
2018/07 - 2021/06	Recetores A2A da adenosina como desencadeadores de disfunção mnemónica na doença de Alzheimer: mecanismos e possibilidade terapêutica Provided by PTCRIS: PTDC/MED-NEU/31274/2017	Fundação para a Ciência e a Tecnologia
2016/05 - 2019/07	Papel dos astrócitos no controlo da memória- foco nos recetores adenosina A2A Provided by PTCRIS: PTDC/NEU-NMC/4154/2014	Fundação para a Ciência e a Tecnologia
2018/01/01 - 2019/06/30	Manipulation of A2A receptors to control symptoms of Angelman syndrome --- Investigador Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação Amélia de Melo Concluído
2013/01 - 2019/02	Tinkering with adenosine metabolism to manipulate adenosine neuromdulation and bolster neuroprotectin in brain disorders Provided by PTCRIS: SFRH/BPD/85404/2012	Fundação para a Ciência e a Tecnologia
2016/10 - 2017/09	Adenosine A2A Receptor Antagonism Affords Integrated Benefits for Neurological Symptoms of Neurofibromatosis Type I W81XWH-18-1-0532 Bolseiro de Pós-Doutoramento Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Congressionally Directed Medical Research Programs Concluído
2012/05 - 2014/08	Papel fisio-patológico da ecto-5`-nucleotidase - um novo alvo para neuroprotecção 122005PRJ	Fundação para a Ciência e a Tecnologia
2011/08 - 2013/12	Localization and metabolism of APP controlling synaptic degeneration in animal models of Alzheimer's disease Provided by PTCRIS: 114810 Bolseiro de Pós-Doutoramento Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação para a Ciência e a Tecnologia
2005/01 - 2008/12	NEURODEGENERATION IN ALZHEIMER´S DISEASE AND PRION RELATED ENCEPHALOPATHIES: THE ROLE OF CYCLIN-DEPENDENT KINASE 5 AND CELL CYCLE REGULATORS Provided by PTCRIS: SFRH/BD/16381/2004	Fundação para a Ciência e a Tecnologia
2003/09/01 - 2004/12/31	A comparative study of the neurotoxic mechanisms of prion and amyloid-beta peptides. Potential neuroprotective strategies POCTI/36101/NSE/1999 Bolseiro de Mestrado Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação para a Ciência e a Tecnologia Concluído

Projeto

	Designação	Financiadores
2023/07/31 - 2029/07/30	Harnessing the potential of VNUT modulation against memory dysfunction in Alzheimer's Disease 2022.05689.CEECIND/CP1714/CT0015 10.54499/2022.05689.CEECIND/CP1714/CT0015 Investigador responsável Universidade de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/01/01 - 2025/12/31	Center for Innovative Biomedicine and Biotechnology - Associate Laboratory LA/P/0058/2020 10.54499/LA/P/0058/2020 Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2019/02/05 - 2023/07/30	Impact of purinergic neuromodulation in neurodegenerative brain pathologies DL 57/2016/CP1448/CT0001 10.54499/DL57/2016/CP1448/CT0001 Investigador responsável Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2019/01/01 - 2019/12/31	CNC. IBILI UID/NEU/04539/2019 Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Coimbra, Portugal Universidade de Coimbra Instituto de Ciências Nucleares Aplicadas à Saúde, Portugal Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Outro

	Designação	Financiadores
2017 - Atual	Study of caffeine derivatives in the inhibition of Alzheimer's disease and as a base for novel drugs - Investigador Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008 - Atual	Causas e consequências da reactivação do ciclo celular nos neurónios: implicações na doença de Alzheimer e nas encefalopatias por priões GAPI 01/08 Bolseiro de Doutoramento Universidade de Coimbra Faculdade de Medicina, Portugal	Concluído
2007 - Atual	Neuroinflamação associada à doenca de Alzheimer GAPI 04/07 Bolseiro de Doutoramento Universidade de Coimbra Faculdade de Medicina, Portugal	Concluído
2006 - Atual	Degeneração neuronal associada à doenca de Alzheimer e às encefalopatias causadas por priões GAI 05/06 Bolseiro de Doutoramento Universidade de Coimbra Faculdade de Medicina, Portugal	Concluído
2005 - Atual	Disfunção colinérgica na doença de Alzheimer: avaliação da capacidade neuroprotectora de compostos com acção antioxidante e inibidora das colinesterases GAI 14/05 Bolseiro de Doutoramento Universidade de Coimbra Faculdade de Medicina, Portugal	Concluído
2004 - Atual	O efeito de novos inibidores das colinesterases na neurotoxicidade do peptídeo beta amilóide. Potenciais agentes terapêuticos na doença de Alzheimer GAI 05/04 Bolseiro de Mestrado Universidade de Coimbra Faculdade de Medicina, Portugal	Concluído
2015/01/01 - 2017/06/30	The up-regulation of hippocampal adenosine A2A receptors is necessary and sufficient to trigger memory dysfunction in Alzheimer's disease Mantero-Bellard Award Investigador Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal	Santa Casa da Misericórdia de Lisboa Concluído

Produções

Publicações

Artigo em conferência	Lopes, João. "Abstracts from Purines 2014, an International Conference on Nucleotides, Nucleosides and Nucleobases, held in Bonn, Germany, from July 23–27, 2014.". 2014.
Artigo em revista	Cátia R. Lopes; António C. Silva; Henrique B. Silva; Paula M. Canas; Paula Agostinho; Rodrigo A. Cunha; João Pedro Lopes. "Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity and of Memory in Mice Exposed to Aß1–42 to Model Early Alzheimer’s Disease". Biomolecules (2023): https://doi.org/10.3390/biom13081173. 10.3390/biom13081173 Cátia R. Lopes; Francisco Q. Gonçalves; Simão Olaio; Angelo R. Tomé; Rodrigo A. Cunha; João Pedro Lopes. "Adenosine A2A Receptors Shut Down Adenosine A1 Receptor-Mediated Presynaptic Inhibition to Promote Implementation of Hippocampal Long-Term Potentiation". Biomolecules (2023): https://doi.org/10.3390/biom13040715. 10.3390/biom13040715 Cátia R. Lopes; Joana S. Silva; Joana Santos; Matilde S. Rodrigues; Daniela Madeira; Andreia Oliveira; Ana Moreira-de-Sá; et al. "Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer’s Disease". International Journal of Molecular Sciences (2023): https://www.mdpi.com/1422-0067/24/8/6968. 10.3390/ijms24086968 Cátia R. Lopes; Andreia Oliveira; Ingride Gaspar; Matilde S. Rodrigues; Joana Santos; Eszter Szabó; Henrique B. Silva; et al. "Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Adenosine Modulation in Different Brain Areas". Biomolecules (2023): https://www.mdpi.com/2218-273X/13/1/106. 10.3390/biom13010106 Ana Patrícia Simões; Francisco Q. Gonçalves; Daniel Rial; Samira G. Ferreira; João Pedro Lopes; Paula M. Canas; Cunha, R.A.. "CD73-Mediated Formation of Extracellular Adenosine Is Responsible for Adenosine A2A Receptor-Mediated Control of Fear Memory and Amygdala Plasticity". International Journal of Molecular Sciences 23 21 (2022): 12826-12826. http://dx.doi.org/10.3390/ijms232112826. 10.3390/ijms232112826 Valada P; Hinz S; Vielmuth C; Lopes CR; Cunha RA; Müller CE; Lopes JP. "The impact of inosine on hippocampal synaptic transmission and plasticity involves the release of adenosine through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors.". Purinergic signalling (2022): http://europepmc.org/abstract/med/36156760. 10.1007/s11302-022-09899-7 Valada P; Alçada-Morais S; Cunha RA; Lopes JP. "Thebromine Targets Adenosine Receptors to Control Hippocampal Neuronal Function and Damage.". International journal of molecular sciences (2022): http://europepmc.org/abstract/med/36142422. 10.3390/ijms231810510 Lopes, C.R.; Amaral, I.M.; Pereira, M.F.; Lopes, J.P.; Madeira, D.; Canas, P.M.; Cunha, R.A.; Agostinho, P.. "Impact of blunting astrocyte activity on hippocampal synaptic plasticity in a mouse model of early Alzheimer's disease based on amyloid-ß peptide exposure". Journal of Neurochemistry 160 5 (2022): 556-567. http://www.scopus.com/inward/record.url?eid=2-s2.0-85124559190&partnerID=MN8TOARS. 10.1111/jnc.15575 Pereira, Marlene F.; Amaral, Inês M.; Lopes, Cátia; Leitão, Catarina; Madeira, Daniela; Lopes, João P.; Gonçalves, Francisco Q.; et al. "l-a-aminoadipate causes astrocyte pathology with negative impact on mouse hippocampal synaptic plasticity and memory". The FASEB Journal 35 8 (2021): http://dx.doi.org/10.1096/fj.202100336r. 10.1096/fj.202100336r Ana Moreira-de-Sá; Francisco Q. Gonçalves; João P. Lopes; Henrique B. Silva; Ângelo R. Tomé; Rodrigo A. Cunha; Paula M. Canas. "Motor Deficits Coupled to Cerebellar and Striatal Alterations in Ube3am-/p+ Mice Modelling Angelman Syndrome Are Attenuated by Adenosine A2A Receptor Blockade". Molecular Neurobiology (2021): https://doi.org/10.1007/s12035-020-02275-9. 10.1007/s12035-020-02275-9 Fernandes, M.Y.D.; Dobrachinski, F.; Silva, H.B.; Lopes, J.P.; Gonçalves, F.Q.; Soares, F.A.A.; Porciúncula, L.O.; et al. "Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices". Scientific Reports 11 1 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85106020393&partnerID=MN8TOARS. 10.1038/s41598-021-89964-0 Lopes, João. "Adenosine A2A receptors format long-term depression and memory strategies in a mouse model of Angelman syndrome.". Neurobiology of disease (2020): https://doi.org/10.1016/j.nbd.2020.105137. 10.1016/j.nbd.2020.105137 Gonçalves, Francisco Q.; Lopes, João P.; Silva, Henrique B.; Lemos, Cristina; Silva, António C.; Gonçalves, Nélio; Tomé, Ângelo R.; et al. "Synaptic and memory dysfunction in a ß-amyloid model of early Alzheimer's disease depends on increased formation of ATP-derived extracellular adenosine". Neurobiology of Disease 132 (2019): 104570. http://dx.doi.org/10.1016/j.nbd.2019.104570. 10.1016/j.nbd.2019.104570 João P. Lopes; Anna Pliássova; Rodrigo A. Cunha. "The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors". Biochemical Pharmacology 166 (2019): 313-321. https://doi.org/10.1016/j.bcp.2019.06.008. 10.1016/j.bcp.2019.06.008 João Pedro Lopes; Rodrigo A. Cunha. "What is the extracellular calcium concentration within brain synapses?". Journal of Neurochemistry 149 4 (2019): 435-437. https://doi.org/10.1111/jnc.14696. 10.1111/jnc.14696 Morató, X.; Gonçalves, F.Q.; Lopes, J.P.; Jauregui, O.; Soler, C.; Fernández-Dueñas, V.; Cunha, R.A.; Ciruela, F.. "Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37-deficient mice". Journal of Neurochemistry 148 6 (2019): 796-809. http://www.scopus.com/inward/record.url?eid=2-s2.0-85060713664&partnerID=MN8TOARS. 10.1111/jnc.14653 Silva, António C.; Lemos, Cristina; Gonçalves, Francisco Q.; Pliássova, Anna V.; Machado, Nuno J.; Silva, Henrique B.; Canas, Paula M.; et al. "Blockade of adenosine A2A receptors recovers early deficits of memory and plasticity in the triple transgenic mouse model of Alzheimer's disease". Neurobiology of Disease 117 (2018): 72-81. http://dx.doi.org/10.1016/j.nbd.2018.05.024. 10.1016/j.nbd.2018.05.024 Pliássova A; Lopes JP; Lemos C; Oliveira CR; Cunha RA; Agostinho P. "The Association of Amyloid-ß Protein Precursor With a- and ß-Secretases in Mouse Cerebral Cortex Synapses Is Altered in Early Alzheimer's Disease.". (2016): http://europepmc.org/abstract/med/26497029. 10.1007/s12035-015-9491-9 Lopes, J.P.; Morató, X.; Souza, C.; Pinhal, C.; Machado, N.J.; Canas, P.M.; Silva, H.B.; et al. "The role of parkinson's disease-associated receptor GPR37 in the hippocampus: Functional interplay with the adenosinergic system". Journal of Neurochemistry (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84928177504&partnerID=MN8TOARS. 10.1111/jnc.13109 Lopes, J.P.; Tarozzo, G.; Reggiani, A.; Piomelli, D.; Cavalli, A.. "Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity". Brain and Behavior 3 2 (2013): 67-74. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893466236&partnerID=MN8TOARS. 10.1002/brb3.118 Capurro, V.; Busquet, P.; Lopes, J.P.; Bertorelli, R.; Tarozzo, G.; Bolognesi, M.L.; Piomelli, D.; Reggiani, A.; Cavalli, A.. "Pharmacological Characterization of Memoquin, a Multi-Target Compound for the Treatment of Alzheimer's Disease". PLoS ONE 8 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874153672&partnerID=MN8TOARS. 10.1371/journal.pone.0056870 Lopes, J.P.; Agostinho, P.. "Cdk5: Multitasking between physiological and pathological conditions". Progress in Neurobiology 94 1 (2011): 49-63. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955109480&partnerID=MN8TOARS. 10.1016/j.pneurobio.2011.03.006 Lopes, J.P.; Oliveira, C.R.; Agostinho, P.. "Neurodegeneration in an Aß-induced model of Alzheimer's disease: The role of Cdk5". Aging Cell 9 1 (2010): 64-77. http://www.scopus.com/inward/record.url?eid=2-s2.0-76249103674&partnerID=MN8TOARS. 10.1111/j.1474-9726.2009.00536.x Lopes, João P.; Oliveira, Catarina R.; Agostinho, Paula. "Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-ß and prion peptides". Cell Cycle 8 1 (2009): 97-104. http://dx.doi.org/10.4161/cc.8.1.7506. 10.4161/cc.8.1.7506 Lopes, J.P.; Oliveira, C.R.; Agostinho, P.. "Cell cycle re-entry in Alzheimer's disease: A major neuropathological characteristic?". Current Alzheimer Research 6 3 (2009): 205-212. http://www.scopus.com/inward/record.url?eid=2-s2.0-67149106183&partnerID=MN8TOARS. 10.2174/156720509788486590 Lopes, J.P.; Blurton-Jones, M.; Yamasaki, T.R.; Agostinho, P.; Laferla, F.M.. "Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not amyloid-ß and tau pathology". Journal of Alzheimer's Disease 16 3 (2009): 541-549. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549145514&partnerID=MN8TOARS. 10.3233/JAD-2009-0993 Lopes, J.P.; Oliveira, C.R.; Agostinho, P.. "Cdk5 acts as a mediator of neuronal cell cycle re-entry triggered by amyloid-ß and prion peptides". Cell Cycle 8 1 (2009): 97-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-60749123603&partnerID=MN8TOARS. Agostinho, P.; Lopes, J.P.; Velez, Z.; Oliveira, C.R.. "Overactivation of calcineurin induced by amyloid-beta and prion proteins". Neurochemistry International 52 6 (2008): 1226-1233. http://www.scopus.com/inward/record.url?eid=2-s2.0-40949104298&partnerID=MN8TOARS. 10.1016/j.neuint.2008.01.005 Lopes, J.P.; Oliveira, C.R.; Agostinho, P.. "Role of cyclin-dependent kinase 5 in the neurodegenerative process triggered by amyloid-beta and prion peptides: Implications for Alzheimer's disease and prion-related encephalopathies". Cellular and Molecular Neurobiology 27 7 (2007): 943-957. http://www.scopus.com/inward/record.url?eid=2-s2.0-37549015597&partnerID=MN8TOARS. 10.1007/s10571-007-9224-3 Santos, P.; Cunha, A.; Lopes, J.P.; Domingos, A.; Regateiro, F.; Segorbe-Luís, A.. "Perfil de expressão génica por PCR em tempo real em doentes VIH negativos com tuberculose multirresistente". Revista Portuguesa de Pneumologia 9 5 (2003): 444. http://dx.doi.org/10.1016/s0873-2159(15)30711-x. 10.1016/s0873-2159(15)30711-x
Capítulo de livro	Lopes, João. "Doenças de priões ou encefalopatias espongiformes". In Neurociências, 561-574. Portugal, 2017. Publicado Lopes, J.P.; Blurton-Jones, M.; Yamasaki, T.R.; Agostinho, P.; LaFerla, F.M.. "Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not aß and tau pathology". 2011. 10.3233/978-1-60750-733-8-139
Poster em conferência	Valada, Pedro; Hinz S; Vielmuth C; Cunha, Rodrigo A.; Müller CE; Lopes, João P.. "The impact of inosine on hippocampal synaptic transmission and plasticity involves adenosine released through equilibrative nucleoside transporters rather than the direct activation of adenosine receptors". Trabalho apresentado em 8th European Synapse Meeting, 2022. Lopes, João P.; Cunha, Rodrigo A.. "Neuroprotective potential of theobromine against ß-amyloid-induced impairment of synaptic plasticity and neurotoxicity". Trabalho apresentado em XVII Meeting of the Portuguese Society for Neuroscience, 2021. Sá, Ana M; Gonçalves, Francisco Q; Lopes, João; Silva, Henrique B.; Tomé, Ângelo R.; Cunha, Rodrigo A; Canas, Paula M. "Pharmacological blockade of adenosine A2A receptors recovers motor learning and grip strength in an Angelman syndrome mouse model". Trabalho apresentado em 1st European Purine Meeting, 2019. Pereira, Malene; Amaral, Inês; Lopes, João; Lopes, Cátia; Leitão, Catarina; Cunha, Rodrigo A.; Agostinho, Paula. "Pharmacological approaches to imping astrocytic function: impact on mouse Hippocampal LTP". Trabalho apresentado em 11th FENS Forum of Neuroscience in Berlin, 2018. Lopes, João; Gonçalves, Nélio. "The blockade of neuronal A2A adenosine receptors prevents impairment by ß-amyloid peptides of hippocampal synaptic plasticity.". Trabalho apresentado em XV Annual Meeting of the Portuguese Society for Neuroscience, 2017. Lopes, João. "The blockade of neuronal A2A adenosine receptors prevents impairment by beta amyloid peptides of hippocampal synaptic plasticity". Trabalho apresentado em 17th Meeting of the Portuguese Society for Neuroscience, 2017. Lopes, João; Gonçalves, Francisco Q; Silva, Henrique B.; Silva, António C; Lemos, Cristina; Gonçalves, Nélio; Oliveira, Catarina R; Agostinho, Paula; Cunha, Rodrigo A.. "ATP-derived adenosine controls Aß-induced impairment of behaviour and synaptic plasticity". Trabalho apresentado em 7th ISN Special Neurochemistry Conference on Synaptic Function and Dysfunction in Brain Diseases, 2016. Lopes, João. "Adenosine A2A receptor critically control the impairment caused by beta amyloid peptides of synaptic plasticity in mouse hippocampal slices". Trabalho apresentado em 15th Meeting of the Portuguese Society for Neuroscience, 2015. Canas, Paula M.; Rial, Daniel; Simões, Ana P.; Lopes, João; Silva, Henrique B.; Machado, Nuno J.; Queiroz, Francisco; et al. "Synaptic and glia involvement in the purinergic control of neurodegenerative diseases". Trabalho apresentado em Purines 2014, an International Conference on Nucleotides, Nucleosides and Nucleobases, 2014. 10.1007/s11302-014-9430-7 Lopes, João; Silva, Henrique B.; Oliveira, Catarina R; Agostinho, P; Cunha, Rodrigo A. "Adenosine A2A receptor blockade and ecto-5’-nucleotidase inhibition abrogate the Aß1-42-induced impairment of mouse hippocampal LTP". Trabalho apresentado em 9th FENS Forum of Neuroscience, 2014. Lopes, João. "The amyloid beta (1-42)-induced impairment of mouse hippocampal LTP is abrogated by adenosine A2A receptor blockade and ecto-5’-nucleotidase inhibition". Trabalho apresentado em XLIV Meeting of the Portuguese Pharmacology Society, 2014. Lopes, João. "The beta amyloid (1-42) peptide-induced impairment of hippocampal LTP is eliminated in adenosine A2A receptor knock-out mice". Trabalho apresentado em 13th Meeting of the Portuguese Society for Neuroscience, 2013. Lopes, João; Blurton-Jones, Mathew; Yamazaki, Tritia R; Agostinho, Paula. "Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not Aß and tau pathology". Trabalho apresentado em Neuroscience 2008, 38th Annual Meeting of the Society for Neuroscience, 2008. Lopes, João; Oliveira, Catarina R; Agostinho, Paula. "Neurodegeneration in Alzheimer's disease and Prion-Related Encephalopathies: the role of cyclin-dependent kinase 5". Trabalho apresentado em 4th Training Course of Neuronal plasticity and neurodegenerative disorders: dysfunction and treatment, 2008. Lopes, João. "Cdk5 as a mediator in neuronal cell cycle reentry in Alzheimer’s Disease and Prion Related Encephalopathies". Trabalho apresentado em 6th FENS Forum, Geneva, Switzerland, 2008. Lopes, João. "Activation of cell cycle proteins in transgenic mice in response to neuronal loss but not Abeta and tau pathology". Trabalho apresentado em 38th Annual Meeting of the Society for Neuroscience, Washington, 2008. Lopes, João; Oliveira, Catarina R; Agostinho, Paula. "Influence of cyclin-dependent kinase 5 in the neurodegenerative process of Alzheimer's Disease and Prion-Related Encephalopathies". Trabalho apresentado em 5th FENS Forum Vienna, 2006. Lopes, João; Oliveira, Catarina R; Agostinho, Paula. "Influence of Cdk5 in the neurotoxicity induced by amyloid-beta and prion peptides". Trabalho apresentado em FEBS Spetses Summer School, 2005. Lopes, João. "Influence of Cdk5 in the neurotoxicity induced by amyloid beta and prion peptides". Trabalho apresentado em 9th Meeting of the Portuguese Society for Neuroscience, 2005. Lopes, João. "Influence of Cdk5 in the neurotoxicity induced by amyloid beta and prion peptides". Trabalho apresentado em FENS Summer School, Ofir, 2005. Santos, P; Lopes, J; Gomes, JM; Pereira, L; Freitas, A; Domingos, A; Regateiro, F; Segorbe-Luís, A. "Mannan-binding lectin (MBL) polymorphisms and protein levels in pulmonary tuberculosis". Trabalho apresentado em 18th European Immunogenetics and Histocompatibility Conference, Sofia, Bulgary, 2004. 10.1038/sj.gene.6364083 Santos, P; Almeida, A; Lopes, J; Domingos, A; Regateiro, F; Segorbe-Luís, A. "Gene expression profile of co-stimulatory receptors, chemokines and cytokines using real-time PCR analysis in multidrug-resistant tuberculosis". Trabalho apresentado em 18th European Immunogenetics and Histocompatibility Conference, Sofia, Bulgary, 2004. 10.1038/sj.gene.6364089 Garção, P; Lopes, João; Oliveira, Catarina R.; Agostinho, Paula. "Neuroinflammation associated to Alzheimer's Disease and Prion-Related Encephalopathies". Trabalho apresentado em Research course "New molecular strategies to treat neurodegenerative diseases" sponsored by FEBS, Ofir, Portugal, 2004. Lopes, João. "The role of microglia in neurodegeneration associated to Alzheimers Disease and Prion-Related Encephalopathies". Trabalho apresentado em 18ª Reunião do Grupo de Estudos Envelhecimento Cerebral e Demência, 2004. Santos, P; Lopes, J; Gomes, JM; Pereira, L; Freitas, A; Domingos, A; Regateiro, F; Segorbe-Luís, A. "Mannan-binding lectin (MBL) deficiency and protection of Mycobacterium tuberculosis infected individuals from progression to pulmonary disease". Trabalho apresentado em 9th European Complement Workshop, Trieste, Italy, 2003. 10.1016/s0161-5890(03)00115-9
Pré-impressão	Sánchez-Fernández, Nuria; Gómez-Acero, Laura; Castañé, Anna; Adell, Albert; Campa, Leticia; Brito, Verónica; Ginés, Silvia; et al. "A combination of ¿9-tetrahydrocannabinol and cannabidiol modulates glutamate dynamics in the hippocampus of an animal model of Alzheimer’s disease". 2024. http://dx.doi.org/10.21203/rs.3.rs-4150742/v1. 10.21203/rs.3.rs-4150742/v1
Resumo em conferência	Lopes, João P.. "Role of adenosine A2A receptors IN the control of synaptic senescence upon aging". Trabalho apresentado em ISN-ESN 2023 Meeting, Porto, 2023. Publicado Lopes, João P.. "Synaptic and glia involvement in the purinergic control of neurodegenerative diseases". Trabalho apresentado em Purines 2014 - International Conference on Nucleotides, Nucleosides and Nucleobases, Bonn, 2014. Publicado Lopes, João P.. "Role of cyclin-dependent kinase 5 in the neurodegenerative process of Alzheimer's disease and prion-related encephalopathies". Trabalho apresentado em 21st Biennial Meeting of the International-Society-for-Neurochemistry/38th Annual Meeting of the American-Society-for-Neurochemistry, Cancun, 2007. Publicado Lopes, João P.. "Gene expression profile of co-stimulatory receptors, chemokines and cytokines using real-time PCR analysis in multidrug-resistant tuberculosis". Trabalho apresentado em 18th European Immunogenetics and Histocompatibility Conference, Sofia, Bulgary, Sofia, 2004. Braga Lopes, João. "Mannan-binding lectin (MBL) polymorphisms and protein levels in pulmonary tuberculosis". Trabalho apresentado em 18th European Immunogenetics and Histocompatibility Conference, Sofia, Bulgary, Sofia, 2004. Publicado Lopes, João P.. "Mannan-binding lectin (MBL) deficiency and protection of Mycobacterium tuberculosis infected individuals from progression to pulmonary disease". Trabalho apresentado em 9th European Meeting on Complement in Human Disease, Trieste, 2003. Publicado
Tese / Dissertação	Lopes, João. "Neurodegeneration associated to Alzheimer's Disease and Prion-Related Encephalopathies: role of cyclin-dependent kinase 5 and the cell cycle regulators". Doutoramento, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2009.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2020/02/07	Neuroprotective potential of theobromine against beta-amyloid-induced impairment of synaptic plasticity and neurotoxicity	L Meeting of the Portuguese Pharmacology Society Sociedade Portuguesa de Farmacologia (Coimbra, Portugal)
2019/09/04	ATP-derived adenosine controls synaptic and memory dysfunction in ß-amyloid models of Alzheimer's disease	1st European Purine Meeting (Santiago de Compostela, Espanha)
2017/02	The blockade of neuronal A2A adenosine receptors prevents impairment by ß-amyloid of hippocampal synaptic plasticity	XLVII Meeting of the Portuguese Pharmacology Society Portuguese Pharmacology Society (Coimbra, Portugal)
2008/08/01	Neurodegeneration in Alzheimer’s disease and Prion-Related Encephalopathies: the role of cyclin-dependent kinase 5	4th Training Course of Neuronal plasticity and neurodegenerative disorders: dysfunction and treatment FENS (Innsbruck, Áustria)
2007/08	Role of cyclin-dependent kinase 5 in the neurodegenerative process of Azheimer’s Disease and Prion-Related Encephalopathies	21st Biennial Meeting of the International Society for Neurochemistry ISN/ASN (Cancun, México)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2022/09/19 - Atual	Alterations in synaptic plasticity and memory in aging and Alzheimer's disease: the role of A2A receptors Orientador	Bioquímica (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2016/02/01 - 2016/07/31	Role of Astrocytes in Synaptic Transmission and Plasticity Orientador	Bioquímica (Outra) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal

Participação em evento

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2024/05/07 - 2024/05/07	Neurologic and memory function alterations - behavior, electrophysiology, neurochemistry and therapeutic opportunities	Engenharia Biomédica (Mestrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2024/01/30 - 2024/01/30	Synaptic function, neurophysiology and cognition - behavioral assessment of memories in animal models	Neurociências Molecular e de Translação (Mestrado integrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2023/03/28 - 2023/03/28	Molecular features & therapeutic opportunities to control memory dysfunction	Engenharia Biomédica (Mestrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2023/01/03 - 2023/01/03	Synaptic function, neurophysiology and cognition - Behavioral assessment of memories in animal models	Neurociências Molecular e de Translação (Mestrado integrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2022/10/19 - 2022/10/19	Biological Models in Neurobiology	Engenharia Biomédica (Mestrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2022/04/05 - 2022/04/05	Neurologic and memory function alterations - behavior, electrophysiology, neurochemistry and therapeutic opportunities	Engenharia Biomédica (Mestrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2021/11/24 - 2021/11/24	Synaptic function, neurophysiology and cognition - Behavioral assessment of memories in animal models	Neurociências Molecular e de Translação (Mestrado integrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2021/04/06 - 2021/04/06	Neurologic and memory function alterations - behavior, electrophysiology, neurochemistry and therapeutic opportunities	Engenharia Biomédica (Mestrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2021/01/11 - 2021/01/15	Neurophysiology and cognition - Synaptic plasticity	Neurociências Molecular e de Translação (Mestrado integrado)	Universidade de Coimbra Faculdade de Medicina, Portugal
2015/10/28 - 2015/10/28	Technologies in Neurobiology Research	Biomedical Engineering (Mestrado integrado)	Universidade de Coimbra Faculdade de Medicina, Portugal

Revisão ad hoc de artigos em revista

	Nome da revista (ISSN)	Editora
2024/02/25 - Atual	European Journal of Pharmacology (1879-0712)	Elsevier
2024/02/24 - Atual	Biochemical Pharmacology (0006-2952)	Elsevier
2024/01/24 - 2024/02/21	Alzheimer's Research & Therapy (1758-9193)	Springer Nature
2019/09/17 - 2019/12/17	Aging Cell (1474-9728)	Wiley (Blackwell Publishing)
2018/07/22 - 2018/11/10	Aging Cell (1474-9728)	Wiley (Blackwell Publishing)
2017/11/07 - 2017/11/27	Alzheimer's & Dementia (1552-5260)	Elsevier
2014/05/28 - 2014/06/21	Journal of Neuroscience Research (1097-4547)	Wiley (John Wiley & Sons)

Tutoria

	Tópico	Nome do aluno
2014/04/28 - 2014/05/20	Hippocampal synaptic plasticity in AD	Inês Barreiros
2008 - 2008	Laboratory practices	Students from the Faculty of Medicine of the University of Coimbra
2007 - 2007	Laboratory practices	Sstudents from the Faculty of Medicine of the University of Coimbra
2006 - 2006	Laboratory practices	Students from the Faculty of Medicine of the University of Coimbra
2005 - 2005	Laboratory practices	Students from the Faculty of Medicine of the University of Coimbra
2004 - 2004	Laboratory practices	Students from the Faculty of Medicine of the University of Coimbra

Distinções

Prémio

2017	Grant for participation in the 17th Meeting of the Portuguese Society for Neuroscience Sociedade Portuguesa de Neurociências, Portugal

Outra distinção

2008	Grant for the attendance of the “4th Training Course of Neuronal plasticity and neurodegenerative disorders: dysfunction and treatment”, Innsbruck, Austria Federation of European Neuroscience Societies, Bélgica
2008	Grant for the attendance of the “6th FENS Forum”, Geneva, Switzerland Sociedade Portuguesa de Neurociências, Portugal
2008	Grant for the attendance of the “Neuroscience 2008, 38th Annual Meeting of the Society for Neuroscience”, Washington, USA Sociedade Portuguesa de Bioquímica, Portugal
2007	Grant for the attendance of the “21st Biennial Meeting of the International Society for Neurochemistry”, Cancun, Mexico, 2007 International Society for Neurochemistry, Suiça
2005	Grant for the attendance of “FEBS/EMBO Summer School”, Spetses, Greece Federation of European Biochemical Societies, Reino Unido

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2017 - Atual	17th Meeting of the Portuguese Society for Neuroscience Encontro	17th Meeting of the Portuguese Society for Neuroscience Sociedade Portuguesa de Neurociências, Portugal
2017 - Atual	XLVII Meeting of the Portuguese Pharmacology Society Encontro	XLVII Meeting of the Portuguese Pharmacology Society Sociedade Portuguesa de Farmacologia, Portugal
2015 - Atual	15th Meeting of the Portuguese Society for Neuroscience Encontro	15th Meeting of the Portuguese Society for Neuroscience Sociedade Portuguesa de Neurociências, Portugal
2014 - Atual	XLIV Meeting of the Portuguese Pharmacology Society Encontro	XLIV Meeting of the Portuguese Pharmacology Society Sociedade Portuguesa de Farmacologia, Portugal
2013 - Atual	13th Meeting of the Portuguese Society for Neuroscience Encontro	13th Meeting of the Portuguese Society for Neuroscience Sociedade Portuguesa de Neurociências, Portugal
2005 - Atual	9th Meeting of the Portuguese Society for Neuroscience Encontro	9th Meeting of the Portuguese Society for Neuroscience Sociedade Portuguesa de Neurociências, Portugal
2023/08/05 - 2023/08/06	ISN Satellite Workshop on Astrocytic Control of Brain Circuits and Behavior Oficina (workshop)	ISN Satellite Workshop on Astrocytic Control of Brain Circuits and Behavior International Society for Neurochemistry, Suiça Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2022/10/21 - 2022/10/22	8th European Synapse Meeting Encontro	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal Universidade de Lisboa Instituto de Medicina Molecular, Portugal
2019 - 2019	1st European Purines Meeting, Santiago de Compostela, Spain, 2019 Congresso	1st European Purines Meeting
2019 - 2019	3rd Spanish and Portuguese Advanced Optical Microscopy Meeting, Coimbra, Portugal Congresso	3rd Spanish and Portuguese Advanced Optical Microscopy Meeting
2016 - 2016	7th ISN Special Neurochemistry Conference on Synaptic Function and Dysfunction in Brain Diseases, Coimbra Congresso	7th ISN Special Neurochemistry Conference on Synaptic Function and Dysfunction in Brain Diseases International Society for Neurochemistry, Suiça
2014 - 2014	9th FENS Forum of Neuroscience, Milan, Italy Congresso	9th FENS Forum of Neuroscience Federation of European Neuroscience Societies, Bélgica
2010 - 2010	Seminar “Primary cells, cell culture and mycoplasma prevention”, Padova,Italy Seminário	Seminar “Primary cells, cell culture and mycoplasma prevention” Istituto Italiano di Tecnologia, Itália
2008 - 2008	4th Neurotrain Event of the Neuroscience Training in Europe “Neuronal plasticity and neurodegenerative disorders: Dysfunction andtreatment”, Innsbruck-Igls, Austria Congresso	4th Neurotrain Event of the Neuroscience Training in Europe Federation of European Neuroscience Societies, Bélgica
2008 - 2008	6th FENS Forum of European Neuroscience, Geneva, Switzerland Congresso	6th FENS Forum Federation of European Neuroscience Societies, Bélgica
2008 - 2008	38th annual meeting of the Society for Neuroscience,Washington, USA Congresso	38th annual meeting of the Society for Neuroscience Society for Neuroscience, Estados Unidos
2007 - 2007	21st Biennial Meeting of the International Society for Neurochemistry, Cancun, Mexico, 2007 Congresso	21st Biennial Meeting of the International Society for Neurochemistry International Society for Neurochemistry, Suiça
2006 - 2006	5th FENS Forum of European Neuroscience, Vienna, Austria Congresso	5th FENS Forum Federation of European Neuroscience Societies, Bélgica
2005 - 2005	FEBS Summer School, Spetses, Greece Congresso	FEBS Summer School, Spetses Federation of European Biochemical Societies, Reino Unido
2005 - 2005	FENS Summer School, Ofir, Portugal Congresso	FENS Summer School, Ofir Federation of European Neuroscience Societies, Bélgica
2004 - 2004	Research course "New molecular strategies to treat neurodegenerative diseases" sponsored by FEBS, Ofir, Portugal Congresso	Research course "New molecular strategies to treat neurodegenerative diseases" Federation of European Biochemical Societies, Reino Unido
2004 - 2004	Workshop on Ageing, organized by the Institute for Interdisciplinary Research, Coimbra, Portugal Oficina (workshop)	Workshop on Ageing Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2004 - 2004	18th meeting of the Group of Studies on Brain Aging and Dementia, Óbidos, Portugal Congresso	18th meeting of the Group of Studies on Brain Aging and Dementia GEECD - Grupo de Estudos de Envelhecimento Cerebral e Demência, Portugal
2002 - 2002	Albert Netter Journeys on "Genetics and Biotechnology in Ginecology" Congresso	Albert Netter Journeys on “Genetics and Biotechnology in Ginecology” Universidade de Coimbra, Portugal