José Alexandre Ferreira (641C-9F20-41B1)

Curriculum Vitae

José Alexandre Ferreira

José Alexandre Ferreira graduated in Chemistry by the University of Aveiro in 2002 and completed an MSc in Food Chemistry in 2004, with specialization in glycochemistry. In 2010 he obtained a PhD degree from the same university in collaboration with the University of Guelph in Ontario in Canada. During his PhD he identified several antigenic glycans from gastric pathogen H. pylori, the main etiologic agent of gastric cancer. Some antigens are currently explored as innovative serological tools based on glycoarrays. He then joined the Mass Spectrometry Center of UA as a postdoctoral researcher to address key roles played by protein glycosylation in cancer combining glycomics and glycoproteomics. In the meantime, he was also the founder of GlyConStruct, a spin-off company aimed to design biotechnological solutions for producing glycopeptides of clinical interest. In 2013, he assumed the coordination of a research team at Portuguese Institute of Oncology of Porto (IPO-Porto), the largest oncology center in Portugal. In 2016, he also became a member the Institute of Research and Innovation in Health (i3S) at the University of Porto, and an invited researcher at the International Iberian Nanotechnology Laboratory, with the objective of fostering the translation of glycan-based technologies into clinical applications. Since then, he has gathered over €700K for human resources in competitive international calls, established a solid platform for graduate training in oncoglycobiology (6 PhD, 20 MSc completed). He currently coordinates several graduate students (6 PhD) and mentors 2 postdoctoral researchers. In 2018 he was promoted to assistant research on a highly competitive international call funded by the Portuguese Science Funding Agency, being ranked top 3% amongst more than 1400 applicants. This success was repeated in 2022, this time in the principal investigator category (only on position awarded). He is currently the CEO and co-founder of GlycoMatters, a biotech startup devoted to the discovery of glyconeoantigens and designing innovative solutions for precision oncology. He often lectures in Master and international courses. He maintains active collaborations with academia and pharmaceutical industry. Since 2016, he has been involved in 5 funded projects in glycosciences, including GlycoCan, a Marie Curie European Training Network composed of 15 leading European partners in glycobiology. In 2016, he became an external scientific evaluator for the European commission (FET-open, ERC Advanced Grants, Marie Currie fellowships) and other relevant international institutions in the UK, France, Spain, The Netherlands and Ireland (DTIF). He was invited as speaker in more than 20 scientific meetings, including the 2017 Human Proteome Organization World Congress, to discuss his achievements in glycoproteomics. He holds 3 patents, 2 provisional patents and 61 publications (>3000 citations; H-index: 26) in relevant peer-reviewed journals, including Molecular Oncology, British Journal of Cancer, Cancer Letters, Oncotarget, Nature Cell Biology, PNAS and Theranostics. His main research topics are the following: i.Understand the molecular mechanisms controlling protein glycosylation alterations relevant to carcinogenesis and cancer progression; ii. Glycoproteogenomics towards novel biomarkers for precision oncology; iii. Development of glycan-based sensors for cancer applications; iv. Development of glycan-based cancer therapies (immunotherapy, nanotherapy) As part of an Oncology Center of Excellence, his research presents a strong translational and market-oriented character, aiming for glycan-based innovations in oncology.

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Identificação

Identificação pessoal

Nome completo: José Alexandre Ferreira
Data de nascimento: 1980/03/27
Género: Masculino

Nomes de citação

Ferreira, José
Ferreira, José Alexandre

Identificadores de autor

Ciência ID: 641C-9F20-41B1
ORCID iD: 0000-0002-0097-6148
Google Scholar ID: https://scholar.google.pt/citations?user=MC0qgQoAAAAJ&hl=en
Scopus Author Id: https://www.scopus.com/authid/detail.uri?authorId=55971688800

Domínios de atuação

Ciências Médicas e da Saúde - Biotecnologia Médica
Ciências Médicas e da Saúde - Ciências da Saúde

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)
Francês	Utilizador independente (B1)	Utilizador independente (B1)	Utilizador independente (B1)	Utilizador independente (B1)
Espanhol; Castelhano	Utilizador independente (B1)	Utilizador proficiente (C1)	Utilizador independente (B1)	Utilizador independente (B1)

Formação

	Grau	Classificação
2010 Concluído	PhD (Doutoramento) Universidade de Aveiro, Portugal "Structural Characterisation of Lipo- and Exopolysaccharides from Helicobacter pylori " (TESE/DISSERTAÇÃO)	aproved by majority
2004 Concluído	Food chemistry and quality (Mestrado) Universidade de Aveiro, Portugal "Structural studies on arabinan-rich pectic polysscharides form Olea europea cell walls. The Effect of ripening and processing." (TESE/DISSERTAÇÃO)
2002 Concluído	Food Chemistry and Biochemistry (Licenciatura) Universidade de Aveiro, Portugal "-" (TESE/DISSERTAÇÃO)

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2023/06/01 - 2029/05/31	Investigador principal (carreira) (Investigação)	Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

2019/05/01 - 2023/05/31	Assistente de Investigação (carreira) (Investigação)	Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2019/04/01 - Atual	CEO	GlycoMatters Biotech, Portugal

2015 - Atual	External Collaborating Professor	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016/02/01 - 2019/01/31	Visiting Researcher Support the development and translation of glycan-based nanothechnology and microfluidic lab-on-a-chip platforms into innovative oncological applications	International Iberian Nanotechnology Laboratory, Portugal

2016/02/01 - 2019/01/31	Senior Posdoc Cancer Glycobiology, Glycomics and Glycoproteomics Mass Spectrometry-based analysis	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

2012/01/01 - 2018/01/01	Team Leader Outline and develop independent research in oncoglycosciences, laboratory and team management, establishment of scientific/business networks, writing scientific reports, student’s supervis	Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

2015 - 2018	senior posdoc	Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

2010/02/01 - 2016/01/31	Postdoctoral researcher in Health Sciences (OncoGlicobiology/Functional Glycomics) Mapping of post-translational modifications (glycans) in relevant cancer-associated glycoproteins by MS envisaging b	Universidade de Aveiro Centro de Espectrometria de Massa, Portugal

2011 - 2013	junior posdoc	Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

2007 - 2013	PhD student	Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal

2005/06/01 - 2010/01/07	PhD student Identification of antigenic glycans for carbohydrate-based vaccines against Helicobacter pylori, the main etiologic agent of gastric diseases. Characterization of complex glycans by GC-MS	Universidade de Aveiro, Portugal

2008/01/01 - 2010/01/01	Entrepreneur Responsible by the spin-off overall management and planning strategies, team leading and motivation activities, outline of business plans, promoting partnerships and product oriented res	Universidade do Minho Centro de Engenharia Biológica, Portugal

2005/06/01 - 2009/10/31	Visiting Scientist Bioengennering. Establishment of bioreactors for high throughput growth of H. pylori envisaging the isolation of cell-surface glycans for vaccine development.	Universidade do Minho Centro de Engenharia Biológica, Portugal

2005/03/01 - 2009/03/01	Visiting Scientist Characterization of complex glycans from bacteria by GC-MS, LC-ESI/MALDI-MS, 1D/2D NMR and immunoblotting for vaccine development under the scope of FCT financed project Pylori E&	University of Guelph, Canadá

2007/10/01 - 2008/10/31	Teaching assistant First year discipline of Elements of Physical Chemistry, BSc in Chemistry and Biology	Universidade de Aveiro, Portugal

2007 - 2007	PhD student	Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal

2004/07/01 - 2005/03/31	Laboratory technician Laboratory and stock management, technical support to several equipments (GC, UV-VIS spectrometers, others), establishment and assuring compliance with the department safety reg	Universidade de Aveiro, Portugal

2002/09/01 - 2003/08/31	Young Researcher Structural characterization of exopolysaccharides by a produced by probiotic bacteria with potential health benefits by enzymatic/chemical methods, GC/LC-MS/NMR, under the scope o	Universidade de Aveiro, Portugal

Projetos

Projeto

	Designação	Financiadores
2021/01/01 - Atual	Rede de Investigação em Saúde: do Laboratório à Saúde Comunitária LA/P/0053/2020 Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal Universidade do Porto Faculdade de Ciências, Portugal Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal Universidade do Algarve, Portugal Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal Universidade da Madeira, Portugal Universidade Nova de Lisboa, Portugal Universidade de Lisboa Centro Cardiovascular da Universidade de Lisboa, Portugal Universidade de Aveiro, Portugal Centro de Investigação em Tecnologias e Serviços de Saúde, Portugal Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal Escola Superior de Enfermagem do Porto, Portugal Universidade do Porto Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2023/06/01 - 2029/05/31	GIVE: Glyco-inspired vaccines for untreatable cancers 10.54499/2022.08311.CEECIND/CP1744/CT0001 Investigador responsável	Fundação para a Ciência e a Tecnologia
2021/01/01 - 2025/12/31	RISE: Health Research Network: From Lab to Community Health LA/P/0053/2020 Investigador	Fundação para a Ciência e a Tecnologia Em curso
2021/01/01 - 2025/12/31	Health Research Network: From Lab to Community Health 10.54499/LA/P/0053/2020 Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal Universidade do Porto Faculdade de Ciências, Portugal Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal Universidade do Algarve, Portugal Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal Universidade da Madeira, Portugal Universidade Nova de Lisboa, Portugal Universidade de Lisboa Centro Cardiovascular da Universidade de Lisboa, Portugal Universidade de Aveiro, Portugal Centro de Investigação em Tecnologias e Serviços de Saúde, Portugal Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal Escola Superior de Enfermagem do Porto, Portugal Universidade do Porto Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2019/05/02 - 2025/05/01	GlycoToLife: Glycan-based solutions for improving metastatic cancer patients' management. CEECIND/03186/2017/CP1475/CT0001 Investigador responsável Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2022/01/01 - 2024/12/31	RESOLVE: Rational Design of Multivalent Glycocode-Inspired Nanovaccines for Gastric Cancer Immunotherapy PTDC/MED-OUT/2512/2021 Investigador responsável Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade de Aveiro, Portugal Universidad de Navarra, Espanha	Fundação para a Ciência e a Tecnologia Em curso
2023/03/01 - 2024/08/31	REVERENT: PRE-CLINICAL VALIDATION OF A GLYCOCODE-INSPIRED VACCINE FOR BLADDER CANCER IMMUNOTHERAPY 2022.03621.PTDC 10.54499/2022.03621.PTDC Co-Investigador Responsável (Co-IR) Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2022/06/01 - 2023/06/01	DCMatters - DC Matters – Combination of dendritic cell vaccine with immune checkpoint inhibitors as first-line therapy in patients with solid malignant neoplasms. NORTE-01-0247-FEDER-047212 Investigador Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2021 - 2023	TeamUp4Cancer: Porto Comprehensive Cancer Center NORTE-01-0145- FEDER-072678 Participating researcher as IPO-Porto member Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal	Comissao de Coordenacao e Desenvolvimento Regional do Norte Em curso
2020 - 2023	IPO Porto Research Center UIDP/00776/2020 Investigador	Fundação para a Ciência e a Tecnologia Em curso
2022/01/01 - 2022/12/28	Pre-clinical validation of a glycocode-inspired vaccine for bladder cancer immunotherapy LPCC-NRN 2022 Investigador responsável Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal	Liga Portuguesa Contra o Cancro Núcleo Regional do Norte
2019/01/17 - 2022/01/16	IPOscore: Predicting the risk of complications of surgical treatment and define prognosis of cancer patients through the integration of clinical and biopathological data DSAIPA/DS/0042/2018 Investigador Instituto de Engenharia Mecânica, Portugal Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2022 - 2022	GlycoSensor: Pre-Clinical Validation of a Point-of-Care Biosensor for Cancer Detection in Whole Blood Based on Abnormal Glycosylation LUB001 Investigador responsável	Em curso
2019/01/31 - 2020/12/28	Establishment of Glycoprotein Signatures for Refinement of Gastric Cancer Patient Molecular Subtyping LPCC-NRN-2019 Investigador responsável Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal	Liga Portuguesa Contra o Cancro Núcleo Regional do Norte
2020/05 - 2020/08	GLYCOVID-19 Testing existing glycan-based drugs to neutralize SARS-CoV- 2 140_596817822 Bolseiro de Investigação	Fundação para a Ciência e a Tecnologia Em curso
2017 - 2020	ESTIMA:Early-stage cancer treatment, driven by context of molecular imaging NORTE-01-0145-FEDER-000027 Bolseiro de Cientista Convidado Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal	European Regional Development Fund Concluído
2019/01/01 - 2019/12/31	Centro de Investigação do Instituto Português de Oncologia do Porto UID/DTP/00776/2019 UID/DTP/04750/2019 UIDB/04750/2020 UIDB/00776/2020 Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal Universidade do Porto Instituto de Saúde Pública, Portugal Universidade do Porto Unidade de Investigação em Epidemiologia, Portugal Universidade do Porto Faculdade de Medicina, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2019/01/01 - 2019/12/31	Institute for Research and Innovation in Health Sciences UID/BIM/04293/2019 LA/P/0070/2020 10.54499/LA/P/0070/2020 Instituto Nacional de Engenharia Biomédica, Portugal Universidade do Porto, Portugal Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2016/02/01 - 2019/01/31	Development and application of a microchip to Circulation Tumour Cells glycoproteome research: A step towards metastasis biomarkers and novel therapeutics SFRH/BPD/111048/2015	Fundação para a Ciência e a Tecnologia Concluído
2017 - 2019	GlyCoCan: Exploiting Glycosylation of Colorectal Cancer for the development of improved diagnostics and therapeutics. 676421 Investigador Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal	EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions Concluído
2015 - 2019	DeCellMab: Trifunctional antibodies and dendritic cell-based technologies: a combined approach to cancer immunotherapy. Bluepharma2015 Investigador Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal	Bluepharma Concluído
2010/02/01 - 2016/01/31	THE ROLE OF MITOCHONDRIA IN THE ENERGY METABOLISM OF TUMOR CELLS: A PROTEOME PERSPECTIVE SFRH/BPD/66288/2009	Fundação para a Ciência e a Tecnologia Concluído
2013/06/01 - 2015/09/30	Zinc-finger nuclease-glycoengineered SimpleCell lines for characterization of the O-glycoproteome of cancer cells. PTDC/BBB-EBI/0786/2012 Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013 - 2015	Pylori GlycoArrays: Development of microarrays from Helicobacter pylori cell surface glycome toward immunological and serological studies. EXPL/BBB-BQB/0750	Fundation for Science and Technology
2013 - 2015	Zinc-finger nuclease-glycoengineered SimpleCell lines for characterization of the O-glycoproteome of cancer cells.: Fundation for Science and Technology PTDC/BBB-EBI/0786/2012	Fundation for Science and Technology
2013/07/01 - 2014/12/31	Pylori GlycoArrays: Development of microarrays from Helicobacter pylori cell surface glycome toward immunological and serological studies info:eu-repo/grantAgreement/FCT/3599-PPCDT/127236/PT Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Associação para a Inovação e Desenvolvimento da FCT, Portugal Universidade de Aveiro, Portugal	Universidade do Algarve Faculdade de Ciências e Tecnologia Concluído
2013/07/01 - 2014/12/31	Pylori GlycoArrays: Development of microarrays from Helicobacter pylori cell surface glycome toward immunological and serological studies EXPL/BBB-BQB/0750/2012 Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal Associação para a Inovação e Desenvolvimento da FCT, Portugal Universidade de Aveiro, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2011/01/01 - 2012/12/31	Strategic Project - UI 62 - 2011-2012 PEst-C/QUI/UI0062/2011 Universidade de Aveiro, Portugal Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2005/06/01 - 2009/05/31	CARACTERIZAÇÃO ESTRUTURAL DE LIPOPOLISSACARÍDEOS DA SUPERFÍCIE DE HELICOBACTER PYLORI E DE EXOPOLISSACARÍ- DEOS ENVOLVIDOS EM PROCESSOS DE ADESÃO SFRH/BD/19929/2004 Universidade de Aveiro, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2005/09/01 - 2008/12/31	4. PYLORI&LPS: Structural Characterization of Lipo- and Exopolysaccharides from Helicobacter pylori - Establishment of the chemical and biochemical basis for the development of vaccines. POCI/QUI/56393/2004 Universidade de Aveiro, Portugal Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Universidade do Minho, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2005/09/01 - 2008/12/31	PYLORI L&EPS: Structural Characterisation of Lipo- and Exopolysaccharides from Helicobacter pylori - Establishment of the chemical and biochemical basis for the development of vaccines and for the understanding of the adhesion processes POCI/QUI/56393/2004 Universidade de Aveiro, Portugal Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal Universidade do Minho, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Outro

	Designação	Financiadores
2021/07/01 - Atual	Phosphoproteomics of hypoxic and glucose deprived bladder cancer cells: the missing link towards systems oncology. EPIC-XS-0000341 Investigador responsável Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal Universiteit Utrecht, Países Baixos	European Proteomics Infrastructure Consortium Providing Access Em curso
2016 - 2022	GlycoMoAbs: Development of monoclonal antibodies based in glycobiomarkers as therapeutics for chemoresistent bladder cancer. CI-IPOP-58-2016-2022 Investigador responsável Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal	Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação Em curso

Produções

Publicações

Artigo em conferência	Coimbra, Manuel A.; Dias, Elsa; Ferreira, José Alexandre; Azevedo, N. F.; Vieira, M. J.; Rocha, Sílvia M.. "Process for detection of Helicobacter pylori using aliphatic amides". 2007. Ferreira, José Alexandre; Azevedo, N. F.; Coimbra, Manuel A.; Vieira, M. J.. "Evidences of exopolysaccharide production by Helicobacter pylori submitted to hydrodynamic stress". 2005.
Artigo em revista	Eiras, Mariana; Soares, Janine; Ferreira, Dylan; Santos, Daniela A. R.; Relvas-Santos, Marta; Santos, Beatriz; Gonçalves, Martina; et al. "Stool Glycoproteomics Signatures of Pre-Cancerous Lesions and Colorectal Cancer". International Journal of Molecular Sciences 25 7 (2024): 3722. http://dx.doi.org/10.3390/ijms25073722. 10.3390/ijms25073722 Freitas, Rui; Ferreira, Eduardo; Miranda, Andreia; Ferreira, Dylan; Relvas-Santos, Marta; Castro, Flávia; Santos, Beatriz; et al. "Targeted and Self-Adjuvated Nanoglycovaccine Candidate for Cancer Immunotherapy". ACS Nano (2024): Publicado Ferreira, Eduardo; Ferreira, Dylan; Relvas-Santos, Marta; Freitas, Rui; Soares, Janine; Azevedo, Rita; Afonso, Luís Pedro; et al. "Aberrantly Glycosylated GLUT1 as a Poor Prognosis Marker in Aggressive Bladder Cancer". International Journal of Molecular Sciences 25 6 (2024): 3462. http://dx.doi.org/10.3390/ijms25063462. Aceite para publicação • 10.3390/ijms25063462 Pereira, Francisca; Domingues, M. Rosário; Vitorino, Rui; Guerra, Inês M. S.; Santos, Lúcio Lara; Ferreira, José Alexandre; Ferreira, Rita. "Unmasking the Metabolite Signature of Bladder Cancer: A Systematic Review". International Journal of Molecular Sciences 25 6 (2024): 3347. http://dx.doi.org/10.3390/ijms25063347. 10.3390/ijms25063347 Freitas, Rui; Miranda, Andreia; Ferreira, Dylan; Relvas-Santos, Marta; Castro, Flávia; Ferreira, Eduardo; Gaiteiro, Cristiana; et al. "A Multivalent CD44 Glycoconjugate Vaccine Candidate for Cancer Immunotherapy". Journal of Controlled Release (2024): Aceite para publicação Freitas, Rui; Ferreira, Eduardo; Miranda, Andreia; Ferreira, Dylan; Relvas-Santos, Marta; Castro, Flávia; Santos, Beatriz; et al. "Targeted and Self-Adjuvated PLGA MUC16-Tn Nanoglycovaccine Candidate for Cancer Immunotherapy". ACS Nano (2024): http://dx.doi.org/10.1021/acsnano.3c12487. Submetido • 10.1021/acsnano.3c12487 Cotton, Sofia; Ferreira, Dylan; Relvas-Santos, Marta; Brandão, Andreia; Luis Afonso; Miranda, Andreia; Ferreira, Eduardo; et al. "E-selectin Affinity Glycoproteomics Reveals Neuroendocrine Proteins and the Secretin Receptor as a Poor Prognosis Signature in Colorectal Cancer". (2024): Submetido Freitas, Rui; Miranda, Andreia; Ferreira, Dylan; Relvas-Santos, Marta; Castro, Flávia; Ferreira, Eduardo; Gaiteiro, Cristiana; et al. "A Multivalent CD44 Glycoconjugate Vaccine for Cancer Immunotherapy". Biomaterials (2024): Em revisão Freitas, Rui; Peixoto, Andreia; Ferreira, Eduardo; Miranda, Andreia; Santos, Lúcio Lara; Ferreira, José Alexandre. "Immunomodulatory glycomedicine: Introducing next generation cancer glycovaccines". Biotechnology Advances 65 (2023): 108144. http://dx.doi.org/10.1016/j.biotechadv.2023.108144. Publicado • 10.1016/j.biotechadv.2023.108144 Poças, Juliana; Marques, Catarina; Gomes, Catarina; Otake, Andreia Hanada; Pinto, Filipe; Ferreira, Mariana; Silva, Tiago; et al. "Syndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival". Proceedings of the National Academy of Sciences 120 20 (2023): http://dx.doi.org/10.1073/pnas.2214853120. 10.1073/pnas.2214853120 Shi, Rongchen; Gao, Yuan; Ferreira, José Alexandre; Luo, Na; Miao, Hongming. "Editorial: Volume II: Tumor microenvironment in cancer hallmarks and therapeutics". Frontiers in Molecular Biosciences 10 (2023): http://dx.doi.org/10.3389/fmolb.2023.1182083. 10.3389/fmolb.2023.1182083 Cristiana Gaiteiro; Janine Soares; Marta Relva-Santos; Andreia Peixoto; Dylan Ferreira; Andreia Brandão; Elisabete Fernandes; et al. "Glycoproteogenomics characterizes the CD44 splicing code associated with bladder cancer invasion". Theranostics (2022): https://www.thno.org/ms/doc/3507/epub/67409k2/pubfile/thno_67409k2_1.pdf. Publicado • 10.1101/2021.09.04.458979 Peixoto, Andreia; Miranda, Andreia; Lúcio Lara Santos; Ferreira, José Alexandre. Autor correspondente: Ferreira, José Alexandre. "A Roadmap for Translational Cancer Glycoimmunology at Single Cell Resolution". J Exp Clinical Cancer Research (2022): No prelo • 10.1186/s13046-022-02335-z Gaiteiro, Cristiana; Soares, Janine; Relvas-Santos, Marta; Peixoto, Andreia; Ferreira, Dylan; Brandão, Andreia; Elisabete Fernandes; et al. "Glycoproteogenomics characterizes the CD44 splicing code associate with bladder cancer invasion". Theranostics 12 7 (2022): 3150-3177. Publicado • 10.7150/thno.67409 Ferreira, José Alexandre; Marta Relvas-Santos; Andreia Peixoto; Lúcio Lara Santos. "Glycoproteogenomics: Setting The Course for Next Generation Cancer Neoantigens Discovery for Cancer Vaccines". (2021): Aceite para publicação Peixoto, Andreia; Ferreira, Dylan; Azevedo, Rita; Freitas, Rui; Fernandes, Elisabete; Relvas-Santos, Marta; Gaiteiro, Cristiana; et al. "Glycoproteomics identifies HOMER3 as a potentially targetable biomarker triggered by hypoxia and glucose deprivation in bladder cancer". Journal of Experimental & Clinical Cancer Research 40 1 (2021): 191. http://dx.doi.org/10.1186/s13046-021-01988-6. No prelo • 10.1186/s13046-021-01988-6 Henrique O. Duarte; Joana G. Rodrigues; Catarina Gomes; Paul J. Hensbergen; Agnes L. Hipgrave Ederveen; Arnoud H. de Ru; Stefan Mereiter; et al. "ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab". Oncogene (2021): https://doi.org/10.1038/s41388-021-01801-w. 10.1038/s41388-021-01801-w Sofia Cotton; Dylan Ferreira; Janine Soares; Andreia Peixoto; Marta Relvas-Santos; Rita Azevedo; Paulina Piairo; et al. "Target Score—A Proteomics Data Selection Tool Applied to Esophageal Cancer Identifies GLUT1-Sialyl Tn Glycoforms as Biomarkers of Cancer Aggressiveness". International Journal of Molecular Sciences (2021): https://www.mdpi.com/1422-0067/22/4/1664. 10.3390/ijms22041664 Silva, Lisete M.; Correia, Viviana G.; Moreira, Ana S.P.; Domingues, Maria Rosário M.; Ferreira, Rui M.; Figueiredo, Céu; Azevedo, Nuno F.; et al. "Helicobacter pylori lipopolysaccharide structural domains and their recognition by immune proteins revealed with carbohydrate microarrays". Carbohydrate Polymers 253 (2021): 117350. http://dx.doi.org/10.1016/j.carbpol.2020.117350. 10.1016/j.carbpol.2020.117350 José Alexandre Ferreira; Marta Relvas-Santos; Andreia Peixoto; André M.N. Silva; Lúcio Lara Santos. "Glycoproteogenomics: Setting the Course for Next-generation Cancer Neoantigen Discovery for Cancer Vaccines". Genomics, Proteomics & Bioinformatics (2021): https://doi.org/10.1016/j.gpb.2021.03.005. 10.1016/j.gpb.2021.03.005 Rui Freitas; Marta Relvas-Santos; Rita Azevedo; Janine Soares; Elisabete Fernandes; Beatriz Teixeira; Lúcio Lara Santos; André M. N. Silva; José Alexandre Ferreira. "Single-pot enzymatic synthesis of cancer-associated MUC16 O-glycopeptide libraries and multivalent protein glycoconjugates: a step towards cancer glycovaccines". New Journal of Chemistry (2021): https://doi.org/10.1039/D0NJ06021F. 10.1039/D0NJ06021F Carvalho, Sandra; Abreu, Catarina M.; Ferreira, Dylan; Lima, Luís; Ferreira, José A.; Santos, Lúcio L.; Ribeiro, Ricardo; et al. "Phenotypic Analysis of Urothelial Exfoliated Cells in Bladder Cancer via Microfluidic Immunoassays: Sialyl-Tn as a Novel Biomarker in Liquid Biopsies". 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Carbohydrate Polymers 231 (2020): 115703-115703. https://doi.org/10.1016/j.carbpol.2019.115703. 10.1016/j.carbpol.2019.115703 Fernandes, Elisabete; Sores, Janine; Cotton, Sofia; Peixoto, Andreia; Ferreira, Dylan; Freitas, Rui; Reis, Celso A.; Santos, Lúcio Lara; Ferreira, José Alexandre. "Esophageal, gastric and colorectal cancers: Looking beyond classical serological biomarkers towards glycoproteomics-assisted precision oncology". Theranostics 10 11 (2020): 4903-4928. http://dx.doi.org/10.7150/thno.42480. 10.7150/thno.42480 Carvalho, Sandra; Abreu, Catarina M; Ferreira, Dylan; Lima, Luís; Ferreira, José Alexandre; Ribeiro, Ricardo; Grenha, Vânia; et al. "Microfluidic-isolation of exfoliated tumor cells from urine: Sialyl-Tn as a new urinary biomarker in bladder cancer". Frontiers (2020): Submetido Elisabete Fernandes; Dylan Ferreira; Andreia Peixoto; Rui Freitas; Marta Relvas-Santos; Carlos Palmeira; Gabriela Martins; et al. 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Capítulo de livro	Peixoto, Andreia; Cotton, Sofia; Santos, Lúcio Lara; Ferreira, José Alexandre. "The Tumour Microenvironment and Circulating Tumour Cells: A Partnership Driving Metastasis and Glycan-Based Opportunities for Cancer Control". In Advances in Experimental Medicine and Biology, 1-33. Springer International Publishing, 2021. 10.1007/978-3-030-73119-9_1 Cova, Marta; Oliveira-Silva, Rui; Ferreira, José Alexandre; Ferreira, Rita; Amado, Francisco; Daniel-da-Silva, Ana Luísa; Vitorino, Rui. "Glycoprotein Enrichment Method Using a Selective Magnetic Nano-Probe Platform (MNP) Functionalized with Lectins". In Methods in Molecular Biology, 83-100. Springer New York, 2014. 10.1007/978-1-4939-1872-0_5 Ferreira, José Alexandre; Silva, Lisete; Monteiro, Mario A.; Coimbra, Manuel A.. "Chapter 6. Helicobacter pylori cell-surface glycans structural features: role in gastric colonization, pathogenesis, and carbohydrate-based vaccines". In Carbohydrate Chemistry, 160-193. Royal Society of Chemistry, 2011. 10.1039/9781849732765-00160 Pintado, Ana. I. E.; Truszkowska, K.; Ferreira, Jos A.; Pintado, Manuela M. E.; Gomes, Ana. M. P.; Coimbra, Manuel A.; Malcata, F. Xavier. "Comparison of Two Processes for Isolation of Exopolysaccharide Produced byLactobacillus acidophilus". In Modern Multidisciplinary Applied Microbiology*, 280-285. Wiley-VCH Verlag GmbH & Co. KGaA, 2006. 10.1002/9783527611904.ch49
Livro	Cova, M.; Oliveira-Silva, R.; Ferreira, J.A.; Ferreira, R.; Amado, F.; Daniel-Da-Silva, A.L.; Vitorino, R.. Glycoprotein enrichment method using a selective magnetic nano-probe platform (Mnp) functionalized with lectins. 2014. 10.1007/978-1-4939-1872-0_5 Ferreira, J.A.; Silva, L.; Monteiro, M.A.; Coimbra, M.A.. Helicobacter pylori cell-surface glycans structural features: Role in gastric colonization, pathogenesis, and carbohydrate-based vaccines. 2011. 10.1039/9781849732765-00160 Pintado, A.I.E.; Truszkowska, K.; Ferreira, J.A.; Pintado, M.M.E.; Gomes, A.M.P.; Coimbra, M.A.; Malcata, F.X.. Comparison of Two Processes for Isolation of Exopolysaccharide Produced by Lactobacillus acidophilus. 2008. 10.1002/9783527611904.ch49
Poster em conferência	Dourado-Gonçalves, Martina; Freitas, Rui; Ferreira, Dylan; Relvas-Santos, Marta; Paulo, Paula; Santos, Lúcio Lara; Andreia Filipa Ferreira Peixoto; Ferreira, José Alexandre. "Decoding the Functional Glycoproteomic Role of Aberrantly Expressed Short-Chain O-Glycans on Gastric Cancer Cells". Trabalho apresentado em Encontro Ciência 2024, 2024. Peixoto, Andreia; Miranda, Andreia; Ferreira, Dylan; Freitas, Rui; Relvas-Santos, Marta; Ferreira, Eduardo; Cotton, Sofia; et al. "Definindo o papel da glicosilação na agressividade do cancro de bexiga: Impacto do microambiente tumoral". Trabalho apresentado em IPO-Porto Summit, 2024. Lourenço, Camila; Miranda, Andreia; Maria José Oliveira; Ferreira, José Alexandre. Autor correspondente: Lourenço, Camila. "GlycoMAPP - Exploring the Impact of Glycosylation on Macrophage Polarization in the Context of Tumour Progression". Trabalho apresentado em 1st Young Researchers day, 2023. Eiras, Mariana; Gaiteiro, Cristiana; Ferreira, Dylan; Amado, Francisco; Ferreira, José Alexandre. "Clinical and Functional Role of CD44 in Gastric Cancer". Trabalho apresentado em 1st Young Researcher's Day, 2023. Freitas, Rui; Miranda, Andreia; Ferreira, Dylan; Relvas-Santos, Marta; Castro, Flávia; Ferreira, Eduardo; Gaiteiro, Cristiana; et al. "Pre-clinical Validation of a Multivalent CD44 Glycoconjugate Vaccine for Cancer Immunotherapy". Trabalho apresentado em 1st Young Researcher's Day, 2023. Soares, Janine; Ferreira, Dylan; Miranda, Andreia; Relvas-Santos, Marta; Brandão, Andreia; Freitas, Rui; Ferreira, Eduardo; et al. "Glycosylation as a driver of Colorectal cancer aggressiveness". Trabalho apresentado em 1st Young Researchers¿s Day, 2023. Ferreira, Eduardo; Freitas, Rui; Miranda, Andreia; Ferreira, Dylan; Relvas-Santos, Marta; Castro, Flávia; Palmeira, Carlos; et al. "A Targeted and Self-Adjuvated PLGA MUC16-Tn Nanoglycovaccine Candidate for Cancer Immunotherapy". Trabalho apresentado em 1st Young Researcher's Day, 2023. Santos, Beatriz; Ferreira, Dylan; Relvas-Santos, Marta; Peixoto, Andreia; Santos, Lúcio; Ferreira, José. "Unravelling the glycomics signature of formalin-fixed paraffin-embedded gastric cancer tissues". Trabalho apresentado em 1st Young Researcher's Day, 2023. Dourado-Gonçalves, Martina; Freitas, Rui; Ferreira, Dylan; Relvas-Santos, Marta; Paulo, Paula; Lara Santos, Lúcio; Ferreira, José Alexandre; Peixoto, Andreia. "Functional Glycoproteomics Characterization of Gastric Cancer Cells Expressing Immature O-Glycans". Trabalho apresentado em 1st Young Researcher's Day, 2023. Relvas-Santos, Marta; Peixoto, Andreia; Ferreira, Dylan; Lara Santos, Lúcio; Silva, André M. N.; Ferreira, José Alexandre. "Exploiting Glycoengineered Simple Cells and Targeted O-glycoproteomics Towards Bladder Cancer Neoantigens". Trabalho apresentado em 1st Young Researchers' Day, 2023. Cotton, Sofia; Ferreira, Dylan; Relvas-Santos, Marta; Brandão, Andreia; André Moreira Neto da Silva; Lúcio Lara Santos; Ferreira, José Alexandre. "The Secretin Receptor as a Prognostic Marker Carrying E-Selectin Ligands in Colorectal Cancer". Trabalho apresentado em 1ST YOUNG RESEARCHERS´DAY, 2023. Freitas, Rui; Miranda, Andreia; Ferreira, Dylan; Gaiteiro, Cristiana; Ferreira, Eduardo; Relvas-Santos, Marta; Soares, Janine; et al. "Production and pre-clinical evaluation of immunogenic CD44 glycoconjugates: setting the molecular bases for novel multivalent anti-cancer glycovaccines". Trabalho apresentado em Trabalho apresentado no XLVIII Annual Meeting of the Portuguese Society for Immunology, 2023. Miranda, Andreia; Freitas, Rui; Ferreira, Dylan; Andreia F. Peixoto; Ferreira, José Alexandre. "Cancer-associated short-chain O-GalNAc glycans induce an immunosuppressive bladder cancer phenotype by impairing dendritic cells function". Trabalho apresentado em XLVII Annual Meeting of the Portuguese Society for Immunology (SPI): At the Crossroads of Human Immunology, 2022. Miranda, Andreia; Ferreira, Dylan; Freitas, Rui; Relvas-Santos, Marta; Palmeira, Carlos; Paulo, Paula; Castro, Flávia; et al. "Cancer-associated short-chain O-GalNAc glycans induce an immunosupressive bladder cancer phenotype by impairing dendritic cells function. Trabalho apresentado no XLVII Annual Meeting of the Portuguese Society for Immunology.". Trabalho apresentado em XLVII Annual Meeting of the Portuguese Society for Immunology, 2022. Miranda, Andreia; Ferreira, Dylan; Freitas, Rui; Relvas-Santos, Marta; Palmeira, Carlos; Paulo, Paula; Castro, Flávia; et al. "Cancer-associated shor-chain O-GalNAc glycans induce an immunosupressive bladder cancer phenotype by impairing dendritic cells function. Trabalho apresentado no XLVII Annual Meeting of the Portuguese Society for Immunology.". Trabalho apresentado em XLVII Annual Meeting of the Portuguese Society for Immunology, 2022. Freitas, Rui; Relvas-Santos, Marta; Pereira Azevedo, Ana Rita ; Soares, Janine; Fernandes, Elisabete; Teixeira, Beatriz; Lara Santos, Lúcio; Silva, André M. N.; Ferreira, José Alexandre. "Single-pot enzymatic synthesis of cancer-associated MUC16 O-glycopeptides libraries and multivalent protein glycoconjugates: a step towards cancer glycovaccines. Trabalho apresentado no XLVII Annual Meeting of the Portuguese Society for Immunology". Trabalho apresentado em XLVII Annual Meeting of the Portuguese Society for Immunology, 2022. Freitas, Rui; Relvas-Santos, Marta; Pereira Azevedo, Ana Rita ; Soares, Janine; Fernandes, Elisabete; Teixeira, Beatriz; Santos, Lúcio; Silva, André M. N.; Ferreira, José Alexandre. "Single-pot enzymatic synthesis of cancer-associated Muc16 O-glycopeptides libraries and multivalent protein glycoconjugates: a step towards cancer glycovaccines". Trabalho apresentado em XLVII Annual Meeting of the Portuguese Society for Immunology, 2022. Freitas, Rui; Relvas-Santos, Marta; Pereira Azevedo, Ana Rita ; Soares, Janine; Fernandes, Elisabete; Beatriz Teixeira; Santos, Lúcio; Silva, André M. N.; Ferreira, José Alexandre. Autor correspondente: Ferreira, José Alexandre. "Enzymatic synthesis of cancer-associated O-glycopeptides libraries and multivalent protein glycoconjugates: translating synthetic glycoepitopes into cancer glycovaccines". Trabalho apresentado em First Summer School in Biomedical Glycoscience, 2022. Freitas, Rui; Relvas-Santos, Marta; Azevedo, Rita; Soares, Janine; Beatriz Teixeira; Fernandes, Elisabete; Silva, André M. N.; Ferreira, José Alexandre; Santos, Lúcio. "Single pot enzymatic synthesis of cancer associated MUC16 O glycopeptide libraries and multivalent protein glycoconjugates: a step towards cancer glycovaccines. Trabalho apresentado no 4th I3S PhDay". Trabalho apresentado em 4th I3S PhDay: Break borders and build opportunities, 2021. Ferreira, Dylan; Freitas, Rui; Fernandes, Elisabete; Gaiteiro, Cristiana; Peixoto, Andreia; Cotton, Sofia; Palmeira, Carlos; et al. "Nucleolin-SLeA as E-Selectin Ligands and Potentially Targetable Biomarkers at the Cell Surface of Gastric Cancer Cells: a flow cytometry-assisted approach". Trabalho apresentado em XVII Congress of the Iberian Society of Cytometry, 2021. Freitas, Rui; Relvas-Santos, Marta; Azevedo, Rita; Fernandes, Elisabete; Lúcio Lara Santos; Ferreira, José Alexandre. "Single-pot enzymatic synthesis of short-chain MUC16 O-sialoglycopeptides and protein glycoconjugates for bioanalytical and biomedical applications. Trabalho apresentado no 13th International Meeting of the Portuguese Carbohydrate Group - Glupor 13". Trabalho apresentado em 13th International Meeting of the Portuguese Carbohydrate Group - Glupor 13, 2019. Freitas, Rui; Relvas-Santos, Marta; Fernandes, Elisabete; Azevedo, Rita; Silva, André M. N.; Lara Santos, Lúcio; Ferreira, José Alexandre. "Single-pot enzymatic synthesis of short-chain MUC16 O-sialoglycopeptides and protein glycoconjugates for bioanalytical and biomedical applications". Trabalho apresentado em 13th International Meeting of the Portuguese Carbohydrate Group - GLUPOR 13 by Freitas R, 2019. Peixoto, Andreia; Fernandes, Elisabete; Gaiteiro, Cristiana; Lima, Luís; Azevedo, Rita; Soares, Janine; Cotton, Sofia; et al. "Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation". Trabalho apresentado em 29th International Carbohydrate Symposium (ICS 2018) by Peixoto A, 2018.
Pré-impressão	Peixoto, Andreia; Ferreira, Dylan; Miranda, Andreia; Relvas-Santos, Marta; Freitas, Rui; Veth, Tim S.; Brandão, Andreia; et al. "Multilevel Plasticity and Altered Glycosylation Drive Aggressiveness in Hypoxic and Glucose-Deprived Bladder Cancer Cells". 2023. http://dx.doi.org/10.1101/2023.10.21.561355. 10.1101/2023.10.21.561355
Recurso online	Peixoto, Andreia; Rui Freitas; Ferreira, Dylan; Relvas-Santos, Marta; Paulo, Paula; Marta Cardoso; Soares, Janine; et al. Autor correspondente: Ferreira, José Alexandre. Metabolomics, Transcriptomics and Functional Glycomics Reveals Bladder Cancer Cells Plasticity and Enhanced Aggressiveness Facing Hypoxia and Glucose Deprivation. 2021. https://www.biorxiv.org/content/10.1101/2021.02.14.431133v1.full.
Tese / Dissertação	Miranda, Andreia Catarina Costa. "Valor biomarcador de glicanos O-GaINAc no controlo terapêutico de NMIBC". Mestrado, 2012. http://hdl.handle.net/10773/10962. Machado, David Alexandre Ferreira. "Perfil O-glicosídico de glicoproteínas urinárias em cancro de bexiga". Mestrado, 2011. http://hdl.handle.net/10773/8181. Ferreira, José Alexandre Ribeiro de Castro. "Structural characterization of Helicobacter Pylori cell-surface lipopolysaccharides and exopolysaccharides". Doutoramento, 2010. http://hdl.handle.net/10773/3228.

Propriedade Intelectual

Patente

Videira, Paula Alexandra Quintela; novo, carlos; Loureiro Liliana; Mylene Carrascal; Ferreira, José Alexandre; Palma, Angelina S.; Lucio Lara Santos; et al. 2019. "L2A5 antibody or functional fragment thereof against tumour antigens". Portugal.
Permitida
Ferreira, José Alexandre; Marta Oliveira; Diéguez, Lorena; Santos, Lúcio Lara; Celso Reis. 2018. "Detection and isolation of cancer cells from body fluids based on a glycosylation pattern and methods of use thereof". Portugal.
Concedida/Emitida
Ferreira, José Alexandre. 2008. "Process for detecting helicobacter pylori using aliphatic amides".

Pedido provisório de patente

2021. "CD44 glycoepitopes and chimeric vaccine glycoconjugates for cancer therapy and synthesis methods thereof".

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2024/07	CD44 glycoproteogenomics towards bladder cancer precision medicine and glycovaccines design.	The 21st European Carbohydrate Symposium, Eurocarb21 (Paris, França)
2023/12	Glyco-inspired vaccines for metastatic cancers.	P.CCC Raquel Seruca Immuno-Oncology Club (Porto, Portugal)
2023/06	Glycoproteogenomic Characterization of CD44 Splicing in Bladder Cancer: Implications for Precision Oncology and Vaccine Development	15th Jenner Glycobiology and Medicine Symposium (Porto, Portugal)
2023/05	Glycoproteogenomics Characterization of the CD44 Splicing Code in Bladder Cancer Towards Precision Oncology	XXIX Porto Cancer Meeting I3s (Porto, Portugal)
2023/01	Unravelling the cancer glycoproteome towards precision oncology and targeted therapeutics	14th International Meeting of the Portuguese Carbohydrate Group – GLUPOR 14 (Caparica, Portugal)
2010	Since 2010 participation in more than 50 scientific international conferences in glycosciences and oncology (30 oral communications, 19 as invited speaker). Highlights: i) 6th Latin American Glycobiology Congress 2021 (Mexico); ii) Onconet-Sudoe Network Meeting 2019 (Spain); iii) 29th International Carbohydrate Symphosium in 2018 (Portugal); iv) 16th Human Proteome Organisation World 2017 (Ireland); v) the EMBO Workshop in 2017Glycobiology and Glycochemistry: Applications in human health and disease 2014 (Portugal)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2022 - Atual	Glycoengineered cell factories for cancer glyconeoantigens production and synthesis of chimeric glycoconjugated cancer vaccines thereof Orientador	Master Degree in Biochemistry (Mestrado) Universidade de Aveiro, Portugal
2020 - Atual	Construction of a multivalent glycan-based nanovaccine for cancer: A step towards effective immunotherapies. Orientador de Marta Relvas Santos	PhD program in Biomedicas Sciences (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019 - Atual	A library of colorectal cancer immunogenic glycopeptides: A step towards novel theragnostics applications. FCT grant SFRH/BD/142479/2018 Orientador de Janine Soares	PhD program in Biomedical Sciences (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - Atual	Chimeric antigen receptor T (CAR-T) cell therapy abnormally cancer-associated protein glycoforms: A step towards novel therapeutics for bladder cancer. FCT grant SFRH/BD/111242/2015 Coorientador de Cristiana Gaiteiro	PhD program in Biomedical Sciences (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022 - 2026	Glycoproteogenomics Patterning in Colorectal Cancer using Deep Learning Approaches Coorientador	Computational Sciences (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal Instituto de Engenharia de Sistemas e Computadores Investigação e Desenvolvimento em Lisboa, Portugal Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2021/01/01 - 2025/12/31	Exploring the Gastric Cancer Glycoproteome Towards Glycan-targeted Chimeric Antigen Receptor (CAR)-T Cells Immunotherapy Orientador	PhD in Biomedical Sciences (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/01/01 - 2025/12/31	Glycovaccines for Bladder Cancer Immunotherapy Orientador	PhD in Biomedical Sciences (Doutoramento) Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
2023/06 - 2024/12	GlycoMAPP - Exploring the Impact of Glycosylation on Macrophage Polarization in the Context of Tumour Progression Orientador	Master in Molecular Medicine and Oncology (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/09 - 2023/12	Functional Glycoproteomics Characterization of Gastric Cancer Cells Expressing Immature O-Glycans Coorientador	Master Degree in Molecular Medicine and Oncology (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/09 - 2023/12	Clinical and Functional Role of CD44 in Gastric Cancer Coorientador	Master's in Applied Biology (Mestrado) Universidade de Aveiro, Portugal
2022/09 - 2023/12	Unmasking the lipid profile of bladder cancer subtypes Coorientador	Master in Biochemistry (Mestrado) Universidade de Aveiro, Portugal
2022/06 - 2023/12	Functional Glycomics and Glycoproteomics Characterization in Gastric Cancer Orientador	Master in Molecular Medicine and Oncology (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2023/02 - 2023/07	GlycoMatters - Project & Business Review Orientador	Master in Bioengineering - Molecular Bioengineering Project (Mestrado) Universidade do Porto Faculdade de Engenharia, Portugal
2023/05 - 2023/06	Development of an anti-tumor vaccine based on glycopeptides with short-chain O-glycans Orientador	BSc in Biotechnology - Curricular Internship (Outra) Instituto Politécnico de Leiria, Portugal
2023/02 - 2023/06	Internship Report Orientador	Master in Molecular Medicine and Oncology - Supervised Laboratory/Clinical Practice (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020 - 2022	Decoding the cross-talk between dendritic cells and bladder cancer: A way to indentify novel immunotherapy targets Orientador	Master course in Molecular Medicine and Oncology (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2015 - 2020	Exploring glycobiomarkers as targets for chemoresistant cells: adding the influence of the hypoxia to the equation FCT grant SFRH/BD/111242/2015 Orientador de Andreia Peixoto	PhD program in Biomedical Sciences (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019 - 2019	A library of colorectal cancer immunogenic glycopeptides: a step towards novel theragnostics Orientador	Ciências Biomédicas (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 - 2019	Improvement of metastatic gastric cancer management glycoexploring circulating tumour cells Coorientador de Dylan Ferreira	Master in Medicine and Molecular Oncology (Mestrado) Universidade do Porto Faculdade de Medicina, Portugal
2018 - 2019	Development of cancer vaccines based on glyco-neoantigens Orientador de Rui Freitas	Master in Clinical Biochemistry (Mestrado) Universidade de Aveiro Centro de Espectrometria de Massa, Portugal
2015 - 2019	Development of monoclonal antibodies for bladder cancer based on glycobiomarkers: Identification of relevant glycoantigens and synthesis methodologies thereof. FCT grant SFRH/BD/105355/2014 Orientador de Ana Rita Azevedo	PhD program in Pathology and Molecular Genetics (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015 - 2019	Glycan-based nanotherapeutics for selective drug delivery in gastric cancer. FCT grant SFRH/BD/103571/2014 Coorientador de Elisabete Fernandes	PhD program in Biomedical Sciences Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 - 2018	Circulating tumour cells glycosylation for improved esophageal and colorectal cancer care: a step towards precision oncology. Orientador	Ciências Biomédicas (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 - 2018	Bladder cancer glycome and glycoproteome microenvironmental regulation: the role of oxygen and glucose Orientador	Bioquímica (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2017 - 2018	Bladder cancer glycome microenviromental regulation: the role of oxygen and glucose. Orientador de Marta Relvas Santos	Master in Biochemistry (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2014 - 2018	Identification and characterization of glycobiomarkers in bladder cancer stem cells. Orientador de Manuel Neves	PhD in Pathology and Molecular Genetics (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2017	Exploring glycobiomarkers for advanced stage bladder cancer: adding the influence of hypoxia and chemoresistance to the equation Orientador	Ciências Biomédicas (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016 - 2017	CD44-glycoprofilling: Establishing the molecular basis for targeted therapeutics in bladder cancer. Orientador de Janine Soares	Master in Clinical Biochemistry (Mestrado) Universidade de Aveiro Centro de Espectrometria de Massa, Portugal
2015 - 2016	Glycoproteomic characterization of advanced bladder cancer towards novel therapies. Coorientador de Sofia Cotton	Master in Cellular and Molecular Biology (Mestrado) Universidade de Aveiro, Portugal
2015 - 2015	Glycoproteomic Characterization of Bladder Cancer Chemoresistant Cells Orientador	Bioquímica (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2015 - 2015	Development of monoclonal antibodies for bladder cancer based on glycobiomarkers: identification of relevant glycoantigens and synthesis methodologies thereof Orientador	Patologia e Genética Molecular (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 - 2014	Glyco-profiling of bladder cancer stem cells based on chemotherapy sorting approach Orientador	Oncologia (Mestrado) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 - 2014	Identification and characterization of glycobiomarkers in bladder cancer stem cells Orientador	Patologia e Genética Molecular (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2014	Helicobacter pylori polysaccharides: structural analysis and carbohydrate-protein interactions using microarrays FCT grant SFRH/BD/71455/2011 Coorientador	Phd in Biochemistry (Doutoramento) Universidade de Aveiro, Portugal
2011 - 2014	Synthesis and optimization of lectin functionalized nanoprobes for the selective recovery of glycoproteins from human body fluids Coorientador de Igor Morgado	Master in Cellular and Molecular Biology (Mestrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2010 - 2014	The sialyl-Tn expression in bladder cancer: biological and clinical significance Coorientador de Sofia Pereira	Phd program in biomedical sciences Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013 - 2013	Clinical Relevance of the Sialyl-Tn antigen in Bladder Cancer Orientador	Bioquímica (Mestrado) Universidade de Aveiro, Portugal
2012 - 2013	Macrophages as biomarkers in BCG treatment response in Bladder-Cancer Orientador de Daniela Oliveira	Master in Biochemistry (Mestrado) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2011 - 2012	Biomarker value of tumor-associated O-glycans in the therapeutic management non-muscle invasive bladder cancer Orientador de Andreia Miranda	Master in Clinical Biochemistry Universidade de Aveiro Centro de Espectrometria de Massa, Portugal
2011 - 2012	Characterization of humoral response against abnormal glycosylation in esophageal cancers Orientador	Master in Clinical Biochemistry (Mestrado) Universidade de Aveiro Centro de Espectrometria de Massa, Portugal
2010 - 2011	O-glycosidic profiling of urinary glycoproteins in the context of bladder cancer. Orientador	Master in Biomolecular Studies (Mestrado) Universidade de Aveiro Centro de Espectrometria de Massa, Portugal
2010 - 2011	Detection of tumor-associated sialylated O-glycans by MALDI-TOF/TOF Orientador	Master in Clinical Biochemistry (Mestrado) Universidade de Aveiro Centro de Espectrometria de Massa, Portugal

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2023/11 - Atual	Organization of the Young Researcher's Day. An event designed to showcase to the scientific community and wider public disruptive science conducted at IPO-Porto. More than 150 atendees. (2023/11) Exposição (Coorganizador)	Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2023 - Atual	Co-organizer of monthly scientific seminars at IPO-Porto dedicated to showcasing disruptive innovations in oncology. The event has a hybrid format (online and in-person) and is open to the public. It provides a good balance between international and national scientists, as well as between established and emerging scientists, aiming to deliver inspirational lectures. (2023) Seminário	Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2023 - Atual	Course on "Life Science Intellectual Property Management and Exploitation," aimed at raising awareness of the intellectual property dimension in life sciences. The course provides tools and a roadmap to enhance technology exploitation. (2023/10) Oficina (workshop) (Coorganizador)	Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2010 - Atual	1. First Precision Oncology Pre-conference workshop on molecular methods in oncology University, Fernando Pessoa (2016). Porto, Portugal; 2. Controversies and developments in digestive cancer Meeting. Pre-course meeting on Bioinformatics. Portuguese Institute of Oncology of Porto. (2015) Porto, Portugal 3. Glyco-T. 9th International Symposium on Glycosyltransferases (2014) Porto, Portugal 4. Proteomics Workshop and Hands-On Proteomics course. (2010) Aveiro, Portugal (2010)

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2023/12 - Atual	I have delivered an inspirational TEDx talk on my journey in the field of glycobiology, discussing how this has led me to propose a paradigm shift in the management of cancer patients.	My journey in the (Bitter)Sweet Cancer Revolution

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2019	Analysis of FGF8 expression in breast cancer cell lines and patient samples. Master in Biochemistry in Health. Arguente principal	Ines Guedes (Mestrado) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2017	The role of the hypoxic microenvironment on the macrophage-tumour cell. Arguente principal	Flávia Martins Oliveira (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2017	Frequent evaluator for the Masters in Biochemistry in Health of the Health School of Porto (>10 thesis) Arguente principal	sevearal (Mestrado)
2015	Role of Carcinoembryonic antigen (CEA) glycosylation in gastric cancer. Arguente principal	Ana Cíntia Silva Barreira (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2015	Bladder Cancer Biopathology associated to Schistosoma Haematobium. Arguente	Júlio Henrique Livramento dos Santos (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014	Effect of active components from garlic on AGEs formation. Arguente principal	Patrick Joel da Silva Pais (Mestrado) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2021 - Atual	Guest Editor. Cancers (Basel) (IF 6.34). “Glycobiomarkers Facing Precision Oncology”; Guest Associate Editor. Frontiers Molecular Biosciences (IF 5.25). “Tumor Microenvironment in Cancer Hallmarks and Therapeutics”, >60,000 views, 51 publications

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2023 - Atual	Evaluator for Future Leaders Fellowships Avaliador	UK Research and Innovation, Reino Unido
2023 - Atual	Evaluator for Open Competition Domain Science-M Avaliador		Nederlandse Organisatie voor Wetenschappelijk Onderzoek
2021 - Atual	Disruptive Technologies Innovation Fund 2020 Call: Evaluator 6 projects	Enterprise Ireland, Irlanda
2019 - Atual	Evaluator for the 2019 27th La Marató de TV3 cancer research grants of promoted by the Agency for Health Quality and Assessment of Catalonia (Spain).
2016 - Atual	1. European Union External Evaluator since 2016: i. Marie Sklodowska Curie Actions in Horizon 2020 Life Sciences Panel: evaluator of >60 projects ; rapporteur of >40 (2016-2023); ii. H2020-FETOPEN-2018-2020: evaluator of >15 projects; iii. FETOPEN-02-2016: progress evaluator 2018-2021 (5 evaluation rounds; 3 as rapporteur); iv) PATHFINDER OPEN-2021: 5 projects; v) EU4Health 2022; vi) ERC Advanced Grants - 2020; vi) EIC PATHFINDER OPEN 2022 and 2023; v) EIC PATHFINDER CHALLANGES 2023 Avaliador	Research Executive Agency, Bélgica	European Commission
2015 - Atual	2015 and 2017: Evaluator of projects for "The William Harvey International Translational Research Academy (WHRI-ACADEMY) (COFUND Marie Curie) Projects (UK)
2015 - Atual	Evaluator for the MATWIN programme: Maturation & accelerating translation of research projects in oncology with potential for industry (France, 2015)

Consultoria / Parecer

	Descrição da atividade	Instituição / Organização
2017 - Atual	Consulting for Oncocellex at at BUSI incubateur d¿Auvergne (France) Consulting for Universal Biosensors (Australia) Consulting for CellmAbs Biopharmaceuticals (Portugal)

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2016 - Atual	Frequently deliver seminars under the context of Master Programmes at the Universities of Porto, Aveiro and Health School of Porto in glycobiology, proteomics, precision medicine and systems biology.

Membro de associação

	Nome da associação	Tipo de participação
2022 - Atual	Society for Glycobiology	Member
2021 - Atual	Portuguese Chemical Society	Member
2021 - Atual	The Human Proteome Organization (HUPO)	Member
2021 - Atual	The European Association for Cancer Research	Member

Outro júri / avaliação

	Descrição da atividade	Instituição / Organização
2017 - Atual	Probationary year doctoral programs evaluation 1. Andreia Marina de Sousa Almeida. Mucoadhesive camptothecin polymeric micelles as nanodelivery systems for oral chemotherapy to treat colorectal cancer. .2017 Doctoral degree in Biomedical Sciences ICBAS-University of Porto. 2. Cláudia Filipa Maia Azevedo. New engineered FcRn-targeting nanoplatforms for oral delivery of biopharmaceuticals. 2017 Doctoral degree in Biomedical Sciences ICBAS-University of Porto.	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Revisão ad hoc de artigos em revista

	Nome da revista (ISSN)	Editora
2014 - Atual	>30, including Cellular and Molecular Life Sciences, Epigenetics, Journal of Molecular Medicine, Theranostics, Carbohydrate Polymers, Wires Nanomedicine and Nanotechnology, Cancer

Tutoria

	Tópico	Nome do aluno
2020 - Atual	Development of glyco-inspired nanovaccines for cancer immunotherapy	Elisabete Fernandes
2019 - Atual	Exploring the glycosylation of circulating tumor cells for precision medicine applications.	Luis Lima
2021/01/01 - 2025/12/31	Exploiting glycans as immune checkpoints in cancer	Andreia Peixoto
2015 - 2019	GlycoStemCells: Glycobiomarkers for personalized therapeutics in bladder cancer. FCT grant SFRH/BDP/101827/2014	Luis Lima

Distinções

Prémio

2022	Best oral communication

Outra distinção

2020	Cover of Theranostics 10(11)
2018	2n prize for the poster: Exploring liquid biopsy and glycosylation for early detection of bladder cancer
2017	3rd best communication: “Exploring the CA 19-9 Glycoproteome of Borrmann Type IV Advanced Gastric Cancer for Guided Therapeutics"
2014	Best poster during poster session “Management strategies in non muscle invasive bladder cancer: From first diagnosis to recurrence”
2014	Bluepharma innovation award for project “DeCellMab: Trifunctional antibodies and dendritic cell-based technologies: a combined approach to cancer immunotherapy”
2014	Honorable Mention for poster: GlycoNanoMed: Antibody-based nanomedicine targeting CA19-9 positive gastric cancer cells.
2013	Best poster award (in more than 150 candidates). Tumor associated carbohydrate antigens sialyl-Tn and sialy-6-T as predictors of BCG immunotherapy response in bladder cancer
2013	The publication "Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced bladder tumours." by Ferreira was cover of Molecular Oncology (IF. 6.7)
2012	2nd Best poster award to the work entitled "Detection of sialylated cancer-associated Thomsen-Friedenreich-related antigens by in-gel deglycosylation and nanoLC-MALDI-TOF/TOF"
2011	Best poster award in the field of clinical proteomics to the work entitled "Biomarker value of urine glycoproteins expressing cancer associated sialyl-Tn (CA 72-4) epitopes for the surveillance of urothelial carcinomas"
2008	Semi-finalist START ward - Portuguese empreendedorism contest. Project GlyConStruct - Yeast-based technologies for the enzymatic synthesis of glycosylated tumor-associated antigens