Guillermin Agüero Chapin (6A1E-E706-A0F1)

Curriculum Vitae

Guillermin Agüero Chapin

Guillermin Agüero Chapin, PhD, is an Auxiliary Researcher at CIIMAR - Centro Interdisciplinar de Investigação Marinha e Ambiental, Universidade do Porto (UP), Portugal (2018-present). He holds a degree in Pharmaceutical Sciences (1998) from Universidad Central de Las Villas (UCLV, Cuba) and recognized in Spain (2013). Master in Biochemistry (2009) from the "Dr. Zerafin de Zarate Ruiz" Medicine School, Cuba (graduated with excellence). He earned his PhD in Biology with honors from UP, Portugal (2009-2013), with a thesis focused on developing TI2BioP, an alignment-free (AF) method for detecting remote functional and evolutionary signals in gene/protein/peptide classes of interest for drug discovery. From 2014 to 2018, he was a Postdoctoral Fellow at CIIMAR, funded by FCT, where he developed the EvoNeering project, an evolutionary platform designed to engineer bioactive peptide synthesis, leveraging AF approaches to unravel ancestral enzymatic activities for innovation in peptide drug discovery. His research expertise spans molecular biology and genetic engineering in plant and microbial biotechnology, with a strong focus on chemo/bioinformatics applied to drug discovery and design, where machine learning, big data-based classifiers, data and algorithm integration and complex networks have been used to predict and analyse bioactive and antimicrobial peptides (AMPs). His research stays in Universities from Italy, Belgium, Spain, Ecuador, Mexico, Germany, Cuba, and Portugal have shaped his current focus on integrating omics data from marine invertebrates and developing screening tools to discover next-generation antibiotics from AMPs. Dr Agüero Chapin has 56 publications in WoS (>90% in Q1 journals). His work has been cited more than 1,000 times (h-index of 17). In the last 5 years, he has published 23 reports in WoS journals, being first and corresponding author in 10 and 7 of them respectively. He has published two books: Alignment-Free Models in Plant Genomics (Nova Science Publishers, USA, 2010) and Computational Approaches in Discovery & Design of Antimicrobial Peptides (MDPI, Switzerland, 2023). He has presented at over 30 scientific conferences and served as Scientific Member and Session Chair for MOL2NET International Conferences (2020-2024). Has been guest editor for Current Topics in Medicinal Chemistry (2015), Antibiotics (2021-2024), Frontiers in Bioinformatics (2022-2024) and Frontiers in Microbiology and Toxins (2024). In 2015, he received the Annual Prize of the Cuban Academy of Sciences. He has co-directed PhD (2016) and MSc (2021) theses, and is currently co-supervising two PhD projects: one in Computational Intelligence at the University of Granada, Spain, and another on the molecular and ecological innovations of marine venoms from cnidarians and molluscs at FCUP, Portugal. In the last 5 years, he has participated in 4 FCT projects, serving as Co-PI on the PTDC/CTA-AMB/31774/2017 project and PI of the COB 2023 project, "Computer-Aided Search for Next Generation Antibiotics from Cephalopods' Salivary Gland Proteomes," funded by CIIMAR/FCT. He has served on academic boards in Portugal (Master, 2021), Spain, and Italy (PhD, 2022-2023), and is a member of the Topic and Reviewer Board for Marine Drugs and Antibiotics (2020-2024). He also reviews for journals such as Scientific Reports, BMC Bioinformatics, and J. Proteome Research, and has evaluated research projects from Universities of Ecuador and Chile and Poultry Industry of Canada in the subject of AMPs. His current research interests focus on the discovery and design of peptide drugs, using both classical and emerging computational tools, with an emphasis on marine sources.

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Identificação

Identificação pessoal

Nome completo: Guillermin Agüero Chapin

Nomes de citação

Agüero-Chapin, G

Identificadores de autor

Ciência ID: 6A1E-E706-A0F1
ORCID iD: 0000-0002-9908-2418
Google Scholar ID: user=3_E35bkAAAAJ&hl
Researcher Id: C-8067-2019
Scopus Author Id: 57194289684

Endereços de correio eletrónico

gchapin@ciimar.up.pt (Profissional)

Telefones

Telefone

223401800 (Profissional)

Moradas

Terminal de Cruzeiros de Leixões. Av. General Norton de Matos s/n, Matosinhos, 4450-208, Porto, Matosinhos, Portugal (Profissional)

Websites

https://www.ciimar.up.pt/members/guillermin-aguero-chapin/ (Profissional)
https://www.webofscience.com/wos/author/record/C-8067-2019 (Académico)
https://scholar.google.com/citations?hl=es&user=3_E35bkAAAAJ (Académico)

Domínios de atuação

Ciências Exatas - Ciências da Computação e da Informação - Bioinformática
Ciências Naturais - Ciências Biológicas - Bioquímica
Ciências Médicas e da Saúde - Medicina Básica - Química Médica
Ciências da Engenharia e Tecnologias - Biotecnologia Industrial - Biocombustíveis
Ciências Agrárias - Biotecnologia Agrária e Alimentar - Biotecnologia Agrária e Biotecnologia Alimentar

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão
Espanhol; Castelhano (Idioma materno)
Inglês	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)
Português	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador independente (B2)

Formação

	Grau	Classificação
2014/04 - 2018/08 Concluído	An Evolution-Based Framework to Engineer the Synthesis of Biologically Active Oligopeptides (Pós-doutoramento) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2013/11/07 Concluído	Programa Doutoral em Biologia, UP (Doutoramento) Universidade do Porto Faculdade de Ciências, Portugal Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal "A Graphical and Numerical Approach for Functional Annotation and Phylogenetic Inference" (TESE/DISSERTAÇÃO)	Aprovado com Distinção
2009/01/28 Concluído	Master in General Biochemistry (Master) Universidad de Ciencias Médicas de Villa Clara, Cuba "Application of the MARCH-INSIDE methodolgy to search more efficient cellulase complexes " (TESE/DISSERTAÇÃO)	excellente (5 in 5) or 20 values
1998/07/17 Concluído	Pharmaceutical Sciences (Bachelor) Universidad Central Marta Abreu de las Villas, Cuba "Study of parameters influencing on banano genetic transformation using gene gun" (TESE/DISSERTAÇÃO)	Excellent (4.88 out of 5) or 19.52 in 20

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2018/09/01 - Atual	Investigador Auxiliar (carreira) (Investigação)	Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
	Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2019/03/01 - 2019/06/30	Investigador visitante (Investigação)	Universitat de València, Espanha
	Universitat de València Facultat de Medicina i Odontologia, Espanha
2014/04 - 2018/08	Pós-doutorado (Investigação)	Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

2018/05 - 2018/07	Investigador visitante (Investigação)	Universidad Central Marta Abreu de las Villas - Centro de Bioactivos Químicos, Cuba

2016/05 - 2016/08	Investigador visitante (Investigação)	Universidad Técnica Particular de Loja Área Biológica y Biomédica, Equador

2016/01 - 2016/04	Investigador visitante (Investigação)	Universidad de Granada Escuela Técnica Superior de Ingenierías Informática y de Telecomunicación, Espanha

2012/06 - 2012/09	Investigador visitante (Investigação)	Katholieke Universiteit Leuven Centrum voor Microbiële en Plantengenetica, Bélgica

2008/09 - 2008/12	Investigador visitante (Investigação)	Universidad de Santiago de Compostela Departamento de Química Orgánica, Espanha

2008/05 - 2008/07	Investigador visitante (Investigação)	Universidade de Vigo, Espanha

2006/09 - 2008/04	Assistente de Investigação (carreira) (Investigação)	Universidad Central Marta Abreu de las Villas - Centro de Bioactivos Químicos, Cuba

2006/03 - 2006/06	Investigador visitante (Investigação)	Università degli Studi di Cagliari Dipartimento Farmaco Chimico Tecnologico, Itália

2002 - 2006	Assistente de Investigação (carreira) (Investigação)	Universidad Central Marta Abreu de las Villas - CAP/Facultad de Química y Farmacia, Cuba

2000 - 2002	Estagiário de Investigação (Investigação)	Universidad Central Marta Abreu de las Villas - Instituto de Biotecnología de las Plantas, Cuba

1998 - 2000	Estagiário de Investigação (Investigação)	Centro de Ingenieria Genetica y Biotecnologia, Cuba

Outros

	Categoria Profissional Instituição de acolhimento	Empregador
2024/08/01 - 2024/09/30	Visiting Researcher at Core Facility Functional Peptidomics, University of Ulm, Germany	Fundação para a Ciência e a Tecnologia, Portugal
	Core Facility Functional Peptidomics, University of ULM, Alemanha
2022/01 - 2022/03	Visiting Researcher at Universidad Nacional Autónoma de México (Instituto de Química)	Fundação para a Ciência e a Tecnologia, Portugal
	Universidad Nacional Autónoma de México Instituto de Quimica, México
2013/11 - 2014/03	Research fellow (project)	Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

2009/09 - 2013/11	PhD student	Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

2008 - 2009	Research fellow (project)	Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
	Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Projetos

Bolsa

	Designação	Financiadores
2023/02/28 - 2024/05/31	Computer-Aided Search for Next Generation Antibiotics from Cephalopods' Salivary Glands Proteomes. UIDB_(COB) Investigador responsável Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal	Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental Em curso
2018/07 - 2021/07	SYMBIOMICS - Omics of marine symbioses: Metabarcoding and metagenomics characterization of host - microbe adaptation and novel biosynthetic gene clusters PTDC/BIA-BMA/29985/2017 NORTE/01/0145/FEDER/029985 Investigador Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal	Fundação para a Ciência e a Tecnologia European Regional Development Fund Concluído
2018/07 - 2021/07	SEXOMICS- Sex and the environment: Genomic decoding and the perpetuation of animal life in a changing world PTDC/CTA-AMB/31774/2017 POCI-01-0145-FEDER/031774/2017 PTDC/CTA-AMB/31774/2017 Co-Investigador Responsável (Co-IR) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal	Fundação para a Ciência e a Tecnologia European Regional Development Fund Concluído
2016/06 - 2019/06	Animal sensory diversity: innovative genomic solutions to enhance perception of environmental stimuli PTDC/AAG-GLO/6887/2014 Investigador Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2014/04/01 - 2018/08	EvoNeering: An Evolution-Based Framework to Engineer the Synthesis of Biologically Active Oligopeptides SFRH/BPD/92978/2013 Bolseiro de Pós-Doutoramento Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2013/10 - 2014/03	Estudo da modelação das vias de sinalização dos retinóides e das hormonas da tiróide, por disruptores endócrinos, em invertebrados PTDC/MAR/115199/2009 Bolseiro de Investigação Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2009/09 - 2013/08	Development of an alignment-free tool based on Quantitative Sequence Function Relationship (QSFR) studies to screen genomes and proteomes of microorganisms: Genomic and proteomic analyses of polyketide synthases and nonribosomal peptide synthetases SFRH/BD/47256/2008 Bolseiro de Doutoramento Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008/04 - 2008/09	Phenogenetic drift in evolution: insights into the genetic basis of vertebrate developmental genes PTDC/BIA-BDE/69144/2006 Bolseiro de Investigação Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2006 - 2008	Searching for efficient cellulase complexes to improve ethanol production from lignocellulosic wastes CYTED IV.21 Bolseiro de Investigação Universidad Central Marta Abreu de las Villas - CAP/Facultad de Química y Farmacia, Cuba	Ciencia y Tecnología para el Desarrollo Ministerio de Educacion Superior Republica Cuba Concluído
2000 - 2002	Lengthening of post-harvest life of tropical fruits through the manipulation of genes involved in ripening process TCP/PER/6713 Bolseiro de Iniciação Científica Universidad Central Marta Abreu de las Villas - Instituto de Biotecnología de las Plantas, Cuba	Food and Agriculture Organization of the United Nations Ministerio de Ciencia Tecnologia y Medio Ambiente Concluído

Projeto

	Designação	Financiadores
2020/09/15 - 2026/09/14	EvoNeering: An Evolution-Motivated Genetic Engineering for the Biosynthesis of Antitumor Peptides derived from Marine Cyanobacteria CEECIND/00543/2018/CP1574/CT0002 10.54499/CEECIND/00543/2018/CP1574/CT0002 Investigador responsável Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2021/01/01 - 2025/12/31	Centro de Investigação Marinha e Ambiental 10.54499/LA/P/0101/2020 Centro de Ciências do Mar, Portugal Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal	Fundação para a Ciência e a Tecnologia Em curso

Produções

Publicações

Artigo em conferência	Castillo-Mendieta, Kevin; Marrero-Ponce, Yovani; Agüero-Chapin, Guillermin; Pérez-Cárdenas, Mariela. Autor correspondente: Agüero-Chapin, Guillermin. "In Silico Discovery of Hemolytic Peptides Through a Novel Approach Based on Network Science and Similarity Searching Methods". Trabalho apresentado em 1st International Electronic Conference on Toxics, Basel, 2024. Agüero-Chapin, G. "Emerging Computational Approaches for Antimicrobial Peptide Discovery". Trabalho apresentado em MOL2NET'22, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 8th ed., Cambridge, 2022. Publicado • https://doi.org/10.3390/mol2net-08-13484 Agüero-Chapin, Guillermin; García-Hernández, Enrique; Ruiz-Blanco, Yasser; Ávila-Barrientos, Luis; Hernández-García, Enrique; Antunes, Agostinho. "Engineering protein fragments via evolutionary and protein-protein interaction algorithms: De novo design of peptide inhibitors for FOF1-ATP synthase.". Trabalho apresentado em MOL2NET'22, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 8th ed., 2022. Publicado • 10.3390/mol2net-08-13936 Marrero-Ponce, Yovani; Romero, Maylin; Rodríguez, Hortensia; Agüero-Chapin, G; Antunes, Agostinho; Aguilera-Mendoza, Longendri; Martinez-Rios, Felix. "A Novel Network Science and Similarity-Searching-Based Approach for Discovering Potential Tumor-Homing Peptides from Antimicrobials". Trabalho apresentado em MOL2NET'22, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 8th ed., 2022. Publicado • 10.3390/mol2net-08-13937 Agüero-Chapin, G. "MOL2NET Highlights on: Graph Theory-Based Sequence Descriptors as Remote Homology Predictors". Trabalho apresentado em MOL2NET 2020, International Conference on Multidisciplinary Sciences, 6th edition, Bilbao, 2020. Publicado • 10.3390/mol2net-06-06819 Agüero-Chapin, G; Pérez-Machado, G; Antunes, Agostinho; Vitor Vasconselos. "The RNase III substrate specificity from that the E. coli’s to the Humans’". Trabalho apresentado em MOL2NET 2020, International Conference on Multidisciplinary Sciences, 6th edition: session USEDAT-08: USA-Europe Data Analysis Training Program Workshop, Miami, 2020. Publicado • 10.3390/mol2net-06-06887 Agüero-Chapin, G. "SeqDivA: Sequence Diversity Analysis Tool for Detecting the Twilight Zone of Alignment Algorithms". Trabalho apresentado em MOL2NET 2020, International Conference on Multidisciplinary Sciences, 6th edition, Bilbao, 2020. Publicado • 10.3390/mol2net-06-06883 Agüero-Chapin, G. "Ensemble K-means for semi-supervised learning in enzymatic activity classification of GH-70 enzymes". Trabalho apresentado em MOL2NET 2020, International Conference on Multidisciplinary Sciences, 6th edition, Valencia, 2020. Publicado • 10.3390/mol2net-06-06891 Galpert Cañizares, D; Fernández, A; Herrera, F; Antunes, A; Molina Ruiz, R; Agüero-Chapin, G. "Surveying Alignment-free Features for Ortholog Detection in Related Yeast Proteomes by using Supervised Big Data Classifiers". Trabalho apresentado em MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th edition, 2018. 10.3390/mol2net-04-05468 Galpert Cañizares, D; del Río García, S; Herrera, F; Ancede Gallardo, E; Antunes, A; Agüero-Chapin, G. "Pairwise Ortholog Detection in Related Yeast Species by Using Big Data Supervised Classifications". Trabalho apresentado em MOL2NET, International Conference on Multidisciplinary Sciences, 2015. Publicado • 10.3390/mol2net-1-e002 Agüero-Chapin, G; Molina Ruiz, R; Antunes, A. "TI2BioP: Topological Indices to BioPolymers". Trabalho apresentado em MOL2NET, International Conference on Multidisciplinary Sciences, 2015. Publicado • 10.3390/mol2net-1-f011 Teijeira, M; Pérez González, M; Morales Helguera, A; Agüero-Chapin, G; Perez Machado, G; Terán, C. "A new approach of the substructural analysis toward the design of A (1) adenosine receptor agonists". Trabalho apresentado em Third Join Italian-German Purine Club Meeting, Camerino, 2009. Publicado • 10.1007/s11302-009-9170-2
Artigo em revista	Guillermin Agüero-Chapin; Dany Domínguez-Pérez; Yovani Marrero-Ponce; Kevin Castillo-Mendieta; Agostinho Antunes. "Unveiling Encrypted Antimicrobial Peptides from Cephalopods’ Salivary Glands: A Proteolysis-Driven Virtual Approach". ACS Omega (2024): https://doi.org/10.1021/acsomega.4c01959. 10.1021/acsomega.4c01959 Castillo-Mendieta, Kevin; Agüero-Chapin, G; Marquez, Edgar A.; Perez-Castillo, Yunierkis; Barigye, Stephen J.; Vispo, Nelson Santiago; García-Jacas, Cesar R.; Marrero-Ponce, Yovani. "Peptide hemolytic activity analysis using visual data mining of similarity-based complex networks". npj Systems Biology and Applications 10 1 (2024): http://dx.doi.org/10.1038/s41540-024-00429-2. 10.1038/s41540-024-00429-2 Kevin Castillo-Mendieta; Guillermin Agüero-Chapin; José R Mora; Noel Pérez; Ernesto Contreras-Torres; José R Valdes-Martini; Felix Martinez-Rios; Yovani Marrero-Ponce. "Unraveling the hemolytic toxicity tapestry of peptides using chemical space complex networks". Toxicological Sciences (2024): https://doi.org/10.1093/toxsci/kfae115. 10.1093/toxsci/kfae115 Daniela de Llano García; Yovani Marrero-Ponce; Guillermin Agüero-Chapin; Francesc J. Ferri; Agostinho Antunes; Felix Martinez-Rios; Hortensia Rodríguez. "Innovative Alignment-Based Method for Antiviral Peptide Prediction". Antibiotics (2024): https://doi.org/10.3390/antibiotics13080768. 10.3390/antibiotics13080768 Castillo-Mendieta, Kevin; Agüero-Chapin, G; Marquez, Edgar; Perez-Castillo, Yunierkis; Barigye, Stephen J.; Pérez-Cárdenas, Mariela; Peréz-Giménez, Facundo; Marrero-Ponce, Yovani. Autor correspondente: Agüero-Chapin, G. "Multiquery Similarity Searching Models: An Alternative Approach for Predicting Hemolytic Activity from Peptide Sequence". Chemical Research in Toxicology 37 4 (2024): 580-589. http://dx.doi.org/10.1021/acs.chemrestox.3c00408. 10.1021/acs.chemrestox.3c00408 Mora, Jose R.; Marquez, Edgar A.; Pérez-Pérez, Noel; Contreras-Torres, Ernesto; Perez-Castillo, Yunierkis; Agüero-Chapin, G; Martinez-Rios, Felix; Marrero-Ponce, Yovani; Barigye, Stephen J.. "Rethinking the applicability domain analysis in QSAR models". Journal of Computer-Aided Molecular Design 38 1 (2024): http://dx.doi.org/10.1007/s10822-024-00550-8. 10.1007/s10822-024-00550-8 Mateo S. Andino; José R. Mora; José L. Paz; Edgar A. Márquez; Yunierkis Perez-Castillo; Guillermin Agüero-Chapin. "Elucidating the Racemization Mechanism of Aliphatic and Aromatic Amino Acids by In Silico Tools". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms241511877. 10.3390/ijms241511877 Guillermin Agüero-Chapin; Agostinho Antunes; Yovani Marrero-Ponce. "A 2022 Update on Computational Approaches to the Discovery and Design of Antimicrobial Peptides". Antibiotics (2023): https://doi.org/10.3390/antibiotics12061011. 10.3390/antibiotics12061011 Guillermin Agüero-Chapin; Agostinho Antunes; José R. Mora; Noel Pérez; Ernesto Contreras-Torres; José R. Valdes-Martini; Felix Martinez-Rios; Cesar H. Zambrano; Yovani Marrero-Ponce. "Complex Networks Analyses of Antibiofilm Peptides: An Emerging Tool for Next-Generation Antimicrobials’ Discovery". Antibiotics (2023): https://doi.org/10.3390/antibiotics12040747. 10.3390/antibiotics12040747 Sebastián Ayala-Ruano; Yovani Marrero-Ponce; Longendri Aguilera-Mendoza; Noel Pérez; Guillermin Agüero-Chapin; Agostinho Antunes; Ana Cristina Aguilar. "Network Science and Group Fusion Similarity-Based Searching to Explore the Chemical Space of Antiparasitic Peptides". ACS Omega (2022): https://doi.org/10.1021/acsomega.2c03398. 10.1021/acsomega.2c03398 Yasser B. Ruiz-Blanco; Guillermin Agüero-Chapin; Sandra Romero-Molina; Agostinho Antunes; Lia-Raluca Olari; Barbara Spellerberg; Jan Münch; Elsa Sanchez-Garcia. "ABP-Finder: A Tool to Identify Antibacterial Peptides and the Gram-Staining Type of Targeted Bacteria". Antibiotics (2022): https://doi.org/10.3390/antibiotics11121708. 10.3390/antibiotics11121708 Contreras-Torres, Ernesto; Marrero-Ponce, Yovani; Terán, Julio E.; Agüero-Chapin, G; Antunes, Agostinho; García-Jacas, César R.. Autor correspondente: Marrero-Ponce, Yovani. "Fuzzy spherical truncation-based multi-linear protein descriptors: From their definition to application in structural-related predictions". Frontiers in Chemistry 10 (2022): http://dx.doi.org/10.3389/fchem.2022.959143. Acesso aberto • Publicado • 10.3389/fchem.2022.959143 Guillermin Agüero-Chapin; Deborah Galpert-Cañizares; Dany Domínguez-Pérez; Yovani Marrero-Ponce; Gisselle Pérez-Machado; Marta Teijeira; Agostinho Antunes. "Emerging Computational Approaches for Antimicrobial Peptide Discovery". Antibiotics 11 7 (2022): 936-936. https://doi.org/10.3390/antibiotics11070936. 10.3390/antibiotics11070936 Luis Pablo Avila-Barrientos; Luis Fernando Cofas-Vargas; Guillermin Agüero-Chapin; Enrique Hernández-García; Sergio Ruiz-Carmona; Norma A. Valdez-Cruz; Mauricio Trujillo-Roldán; et al. "Computational Design of Inhibitors Targeting the Catalytic ß Subunit of Escherichia coli FOF1-ATP Synthase". Antibiotics 11 5 (2022): 557-557. https://doi.org/10.3390/antibiotics11050557. 10.3390/antibiotics11050557 Maylin Romero; Yovani Marrero-Ponce; Hortensia Rodríguez; Agüero-Chapin G; Agostinho Antunes; Longendri Aguilera-Mendoza; FELIX MARTINEZ-RIOS. "A Novel Network Science and Similarity-Searching-Based Approach for Discovering Potential Tumor-Homing Peptides from Antimicrobials". Antibiotics (2022): https://www.mdpi.com/2079-6382/11/3/401. 10.3390/antibiotics11030401 Agüero-Chapin, G. "DISTATIS: A Promising Framework to Integrate Distance Matrices in Molecular Phylogenetics.". Current Topics in Medicinal Chemistry (2021): https://doi.org/10.2174/1568026621666210113164605. 10.2174/1568026621666210113164605 Agüero-Chapin, G. "Promising Probiotic Food Supplement Based on Combination of Yeast Beta-Glucan, Bioselenium and Lactoferrin for Animal Health". Biomedical Journal of Scientific & Technical Research (2020): https://biomedres.us/fulltexts/BJSTR.MS.ID.005271.php. 10.26717/BJSTR.2020.32.005271 Daniela Almeida; Dany Domínguez-Pérez; Ana Matos; Guillermin Agüero-Chapin; Yuselis Castaño; Vitor Vasconcelos; Alexandre Campos; Agostinho Antunes. "Data Employed in the Construction of a Composite Protein Database for Proteogenomic Analyses of Cephalopods Salivary Apparatus". Data 5 4 (2020): 110-110. https://doi.org/10.3390/data5040110. 10.3390/data5040110 Agüero-Chapin, G. "Engineering protein fragments via evolutionary and protein-protein interaction algorithms: De novo design of peptide inhibitors for F O F 1 -ATP synthase". FEBS Letters (2020): http://dx.doi.org/10.1002/1873-3468.13988. 10.1002/1873-3468.13988 Daniela Almeida; Dany Domínguez-Pérez; Ana Matos; Guillermin Agüero-Chapin; Hugo Osório; Vitor Vasconcelos; Alexandre Campos; Agostinho Antunes. "Putative Antimicrobial Peptides of the Posterior Salivary Glands from the Cephalopod Octopus vulgaris Revealed by Exploring a Composite Protein Database". Antibiotics 9 11 (2020): 757-757. https://doi.org/10.3390/antibiotics9110757. 10.3390/antibiotics9110757 González Valle, Y; Galpert Cañizares, D.; Molina-Ruiz, Reinaldo; Agüero-Chapin, G. "Integración de rasgos y aprendizaje semi-supervisado para la clasificación funcional de enzimas utilizando K-medias de Spark". Revista Cubana de Ciencias Informáticas 14 4 (2020): 134-161. https://rcci.uci.cu/?journal=rcci&page=article&op=view&path[]=2021&path[]=834. Publicado Ana Matos; Dany Domínguez-Pérez; Daniela Almeida; Guillermin Agüero-Chapin; Alexandre Campos; Hugo Osório; Vitor Vasconcelos; Agostinho Antunes. "Shotgun Proteomics of Ascidians Tunic Gives New Insights on Host–Microbe Interactions by Revealing Diverse Antimicrobial Peptides". Marine Drugs (2020): https://doi.org/10.3390/md18070362. 10.3390/md18070362 Daniela Sánchez-Soto; Guillermin Agüero-Chapin; Vinicio Armijos-Jaramillo; Yunierkis Perez-Castillo; Eduardo Tejera; Agostinho Antunes; Aminael Sánchez-Rodríguez. "ShadowCaster: Compositional Methods under the Shadow of Phylogenetic Models to Detect Horizontal Gene Transfers in Prokaryotes". Genes (2020): https://doi.org/10.3390/genes11070756. 10.3390/genes11070756 Agüero-Chapin; Galpert; Molina-Ruiz; Ancede-Gallardo; Pérez-Machado; de la Riva; Antunes. "Graph Theory-Based Sequence Descriptors as Remote Homology Predictors". Biomolecules 10 1 (2019): 26. http://dx.doi.org/10.3390/biom10010026. 10.3390/biom10010026 de la Riva, G.A; Mendoza, F.L; Agüero-Chapin, G. "Known Hepatoprotectors Act as Antioxidants and Immune Stimulators in Stressed Mice. Perspectives in Animal Health Care". Current Pharmaceutical Design 25 (2019): http://dx.doi.org/10.2174/1381612825666190116151628. 10.2174/1381612825666190116151628 Domínguez-Pérez, D; Durban, J; Agüero-Chapin, G; López, J.T; Molina-Ruiz, R; Almeida, D; Calvete, J. J; Vasconcelos, Vítor; Antunes, A. "The Harderian gland transcriptomes of Caraiba andreae, Cubophis cantherigerus and Tretanorhinus variabilis, three colubroid snakes from Cuba". Genomics (2018): http://dx.doi.org/10.1016/j.ygeno.2018.11.026. Acesso aberto • Publicado • 10.1016/j.ygeno.2018.11.026 Deborah Galpert; Alberto Fernández; Francisco Herrera; Agostinho Antunes; Reinaldo Molina-Ruiz; Guillermin Agüero-Chapin. "Surveying alignment-free features for Ortholog detection in related yeast proteomes by using supervised big data classifiers". BMC Bioinformatics (2018): https://doi.org/10.1186/s12859-018-2148-8. 10.1186/s12859-018-2148-8 Ruiz-Blanco, Y.B; Agüero-Chapin, G; García-Hernández, E; Álvarez, O; Antunes, A; Green, J. "Exploring general-purpose protein features for distinguishing enzymes and non-enzymes within the twilight zone". BMC Bioinformatics 18 1 (2017): https://doi.org/10.1186/s12859-017-1758-x. 10.1186/s12859-017-1758-x Colli Mull, J. G; de la Riva, G.A; Vargas Samano, C.D; Perez Machado, G; Agüero-Chapin, G. "Plant Growth Promoting Bacteria Isolated From a Mexican Natural Ecosystem Induce Water Stress Resistance in Maize and Sorghum Plants". Journal of Microbial & Biochemical Technology 9 5 (2017): http://dx.doi.org/10.4172/1948-5948.1000367. 10.4172/1948-5948.1000367 Agüero-Chapin, G. "Métodos grafo-numéricos de relevancia para la bioinformática. Aplicaciones en la biotecnología vegetal y en el descubrimiento de fármacos.". Anales de la Academia de Ciencias de Cuba 69 2 (2017): http://www.revistaccuba.cu/index.php/revacc/article/view/263/0. Publicado Agüero-Chapin, G; Pérez-Machado, G; Colli Mull, J. G; Ancede-Gallardo, E; Antunes, A; de la Riva, G.A. "How the Protein Architecture of RNases III Influences their Substrate Specificity?". Current Pharmaceutical Design 22 33 (2016): 5065-5071. http://dx.doi.org/10.2174/1381612822666160511150416. 10.2174/1381612822666160511150416 Diaz-Garcia, C; Agüero-Chapin, G; Antunes, A; Vasconcelos, V. "Editorial (Thematic Issue: Biological Toxins and Medicinal Chemistry: Research and Therapeutic Tools)". Current Topics in Medicinal Chemistry 15 7 (2015): 580-580. http://dx.doi.org/10.2174/1568026615666150217110223. Publicado • 10.2174/1568026615666150217110223 • Editor Galpert, D; del Río, S ; Herrera, F; Ancede-Gallardo, E; Antunes, A; Agüero-Chapin, G. "An Effective Big Data Supervised Imbalanced Classification Approach for Ortholog Detection in Related Yeast Species". BioMed Research International 2015 (2015): 1-12. http://dx.doi.org/10.1155/2015/748681. Acesso aberto • 10.1155/2015/748681 de la Riva, G.A; Mull-Collí, J; Ramón-Quiroz, R; García-Ramírez, L; Agüero-Chapin, G. "A Bacterial Strain that Affects Lifecycle of Whiteflies (Bemisia tabaci G, Hemiptera: Aleyrodidae) Isolated from the Charco Azul, Xichú, Guanajuato (Mexico)". Journal of Pure and Applied Microbiology 8 2 (2014): 1031-1042. Publicado Agüero-Chapin, G; Molina-Ruiz, R; Maldonado, E; de la Riva, G; Sánchez-Rodríguez, A; Vasconcelos, V; Antunes, A. "Exploring the Adenylation Domain Repertoire of Nonribosomal Peptide Synthetases Using an Ensemble of Sequence-Search Methods". PLoS ONE 8 7 (2013): e65926. http://dx.doi.org/10.1371/journal.pone.0065926. 10.1371/journal.pone.0065926 Chapin, Guillermin Agüero. "A graphical and numerical approach for functional annotation and phylogenetic inference". Universidade do Porto (Portugal) (2013): https://publons.com/wos-op/publon/17638569/. Agüero-Chapin, G; Sánchez-Rodríguez, A; Hidalgo-Yanes, P.I.; Pérez-Castillo, Y; Molina-Ruiz, R; Marchal, K; Vasconcelos, V; Antunes, A. "An Alignment-Free Approach for Eukaryotic ITS2 Annotation and Phylogenetic Inference". PLoS ONE 6 10 (2011): e26638. http://dx.doi.org/10.1371/journal.pone.0026638. 10.1371/journal.pone.0026638 Agüero-Chapin, G; de la Riva, G.A; Molina-Ruiz, R; Sánchez-Rodríguez, A; Pérez-Machado, G; Vasconcelos, Vítor; Antunes, A. "Non-linear models based on simple topological indices to identify RNase III protein members". Journal of Theoretical Biology 273 1 (2011): 167-178. http://dx.doi.org/10.1016/j.jtbi.2010.12.019. Publicado • 10.1016/j.jtbi.2010.12.019 Agüero-Chapin, G; Pérez-Machado, G; Molina-Ruiz, R; Pérez-Castillo, Y; Morales-Helguera, A; Vasconcelos, V; Antunes, A. "TI2BioP: Topological Indices to BioPolymers. Its practical use to unravel cryptic bacteriocin-like domains". Amino Acids 40 2 (2010): 431-442. http://dx.doi.org/10.1007/s00726-010-0653-9. 10.1007/s00726-010-0653-9 González-Díaz, H; Dea-Ayuela, M.A; Pérez-Montoto, L.G; Prado-Prado, F.J; Agüero-Chapin, G; Bolas-Fernández, F; Vazquez-Padrón, R.I; Ubeira, F. "QSAR for RNases and theoretic–experimental study of molecular diversity on peptide mass fingerprints of a new Leishmania infantum protein". Molecular Diversity 14 2 (2009): 349-369. http://dx.doi.org/10.1007/s11030-009-9178-0. Publicado • 10.1007/s11030-009-9178-0 Agüero-Chapin, G; Varona-Santos, Javier; de la Riva, G.A; Antunes, A; González-Villa, T; Uriarte, E; González-Díaz, H. "Alignment-Free Prediction of Polygalacturonases with Pseudofolding Topological Indices: Experimental Isolation fromCoffea arabicaand Prediction of a New Sequence". Journal of Proteome Research 8 4 (2009): 2122-2128. http://dx.doi.org/10.1021/pr800867y. Publicado • 10.1021/pr800867y González-Díaz, H; Cabrera-Pérez, M.A; Agüero-Chapín, G; Cruz-Monteagudo, M; Castañeda-Cancio, N; del Río, M.A; Uriarte, E. "Multi-target QSPR assemble of a Complex Network for the distribution of chemicals to biphasic systems and biological tissues". Chemometrics and Intelligent Laboratory Systems 94 2 (2008): 160-165. http://dx.doi.org/10.1016/j.chemolab.2008.07.006. Publicado • 10.1016/j.chemolab.2008.07.006 Agüero-Chapín, G; Antunes, A; Ubeira, F.M; Chou, KC; González-Díaz, H. "Comparative Study of Topological Indices of Macro/Supramolecular RNA Complex Networks". Journal of Chemical Information and Modeling 48 11 (2008): 2265-2277. http://dx.doi.org/10.1021/ci8001809. 10.1021/ci8001809 Agüero-Chapín, G; González-Díaz, H; de la Riva, G.A; Rodríguez, E; Sánchez-Rodríguez, A; Podda, G; Vazquez-Padrón, R.I. "MMM-QSAR Recognition of Ribonucleases without Alignment:¿ Comparison with an HMM Model and Isolation from Schizosaccharomyces pombe, Prediction, and Experimental Assay of a New Sequence". Journal of Chemical Information and Modeling 48 2 (2008): 434-448. http://dx.doi.org/10.1021/ci7003225. 10.1021/ci7003225 Cruz-Monteagudo, M; González-Díaz, H; Agüero-Chapín, G; Santana, L; Borges, F; Domínguez, E.R; Podda, G; Uriarte, E. "Computational chemistry development of a unified free energy Markov model for the distribution of 1300 chemicals to 38 different environmental or biological systems". Journal of Computational Chemistry 28 11 (2007): 1909-1923. http://dx.doi.org/10.1002/jcc.20730. 10.1002/jcc.20730 González-Díaz, H; Agüero-Chapin, G; Varona, J; Molina, R; Delogu, G; Santana, L; Uriarte, E; Podda, G. "2D-RNA-coupling numbers: A new computational chemistry approach to link secondary structure topology with biological function". Journal of Computational Chemistry 28 6 (2007): 1049-1056. http://dx.doi.org/10.1002/jcc.20576. 10.1002/jcc.20576 Agüero-Chapin, G; González-Díaz, H; Molina, R; Varona-Santos, J; Uriarte, E; González-Díaz, Y. "Novel 2D maps and coupling numbers for protein sequences. The first QSAR study of polygalacturonases; isolation and prediction of a novel sequence fromPsidium guajavaL.". FEBS Letters 580 3 (2006): 723-730. http://dx.doi.org/10.1016/j.febslet.2005.12.072. 10.1016/j.febslet.2005.12.072 Agüero-Chapin, G; Fouad Sarrouh, B; Jover de la Prida, J; González Suarez, E. "Estudio de la hidrólisis del bagazo con ácido sulfúrico concentrado utilizando dos variantes de una sola etapa y una sola etapa modificada para la obtención de etanol y análisis técnico-económico de dicho proceso". Revista Cubana de Química 18 1 (2006): 95. https://www.redalyc.org/pdf/4435/443543688040.pdf. González-Díaz, H; Agüero-Chapin, G; Cabrera, M.A; Molina, R; Santana, L; Uriarte, E; Delogu, G; Castañedo, N. "Unified Markov thermodynamics based on stochastic forms to classify drugs considering molecular structure, partition system, and biological species:". Bioorganic & Medicinal Chemistry Letters 15 3 (2005): 551-557. http://dx.doi.org/10.1016/j.bmcl.2004.11.059. 10.1016/j.bmcl.2004.11.059 Fouad Sarrouh, B; Agüero-Chapin, G; Jover de la Prida, J; González Suarez, E. "Estudio de la hidrólisis del bagazo con ácido sulfúrico concentrado para la obtención de etanol". Centro Azúcar 32 2 (2005): 39-42. http://centroazucar.uclv.edu.cu/media/articulos/PDF/2009/4/6.pdf. Mesa Garriga, L; González Suarez, E; González Cortés, M; Agüero-Chapin, G. "La producción de etanol: alternativas de materias primas". Revista Cubana de Química 17 1 (2005): 129-137. https://www.redalyc.org/pdf/4435/443543685055.pdf. Vazquez-Padrón, R.I; de la Riva, G.A; Agüero, Guillermin; Silva, Yussun; Pham, Si.M; Soberón, M; Bravo, A; Abdelouahab, A. "Cryptic endotoxic nature of Bacillus thuringiensis Cry1Ab insecticidal crystal protein". FEBS Letters 570 1-3 (2004): 30-36. http://dx.doi.org/10.1016/j.febslet.2004.06.021. 10.1016/j.febslet.2004.06.021 Agüero-Chapin, G; Jover de la Prida, J; Mesa Garriga, L; González Suarez, E. "Avances en la producción de bioetanol a partir de residuos lignocelulósicos.". Centro Azúcar 31 4 (2004): 28-30. http://centroazucar.uclv.edu.cu/media/articulos/PDF/2009/4/6.pdf. Mesa Garriga, L; Agüero-Chapin, G; González Suarez, E. "Obtención de coproductos a partir de residuos de tecnologías utilizadas para obtener biocombustibles.". Centro Azúcar 31 3 (2004): 38-40. http://centroazucar.uclv.edu.cu/media/articulos/PDF/2009/4/6.pdf. Agüero-Chapin, G; Rodríguez, E; Díaz, L; Bacallao, N; Jiménez, Elio. "Aislamiento de un fragmento del ADNc ACC Oxidasa expresado durante la maduración del fruto de Guayaba Enana". Biotecnología Vegetal 3 2 (2003): 187-189. https://revista.ibp.co.cu/index.php/BV/article/view/259/868. Publicado Mas, L; Agüero-Chapin, G; Gil, V; Reyes, M; Gómez Kosky, R; Ocaña, Bárbara; Martínez, S. "Optimización de parámetros en la transformación de embriones somáticos de banano utilizando pistola de genes". Revista Biotecnología Vegetal 1 (2000): 51-54. https://biblat.unam.mx/es/revista/biotecnologia-vegetal/articulo/optimizacion-de-parametros-en-la-transformacion-de-embriones-somaticos-de-banano-utilizando-pistola-de-genes.
Capítulo de livro	Galpert-Cañizares, D; del Río, S ; Herrera, F; Ancede-Gallardo, Evys; Antunes, A; Agüero-Chapin, G. "Big Data Supervised Pairwise Ortholog Detection in Yeasts". In Yeast - Industrial Applications, 42-63. Croácia: InTech, 2017. 10.5772/intechopen.70479 Agüero-Chapin, G; Molina-Ruiz, R; Pérez-Machado, G; Vasconcelos, Vítor; Rodríguez-Negrin, Z; Antunes, A. "TI2BioP — Topological Indices to BioPolymers. A Graphical– Numerical Approach for Bioinformatics". In Recent Advances in Biopolymers, 254-277. Croácia: InTech, 2016. 10.5772/61887 Agüero-Chapin, G; Pérez-Machado, G; Sánchez-Rodríguez, A; Santos, M; Antunes, A. "Alignment-Free Methods for the Detection and Specificity Prediction of Adenylation Domains". In Nonribosomal Peptide and Polyketide Biosynthesis, 253-272. Estados Unidos: Springer New York, 2016. 10.1007/978-1-4939-3375-4_16 González-Díaz, H; Agüero-Chapin, G; Munteanu, C; Prado-Prado, F.J; Chou, KC; Duardo-Sanchez, A; Patlewicz, G; López-Díaz, Antonio. "Alignment-free models in Plant Genomics: Theoretical, Experimental, and Legal issues". In Advances in Genetics Research, editado por Maria A. Osborne. New York, Estados Unidos: Nova Science Publisher, 2011. Publicado
Livro	Galpert Cañizares, D; Agüero-Chapin, G; Molina-Ruiz, R; Bello-Perez, R. Inteligencia artificial y otras tecnologías para una sociedad digital.. Havana, Cuba: Universidad de La Habana, Ciudad Habana. 2024. No prelo Agüero-Chapin, G. Computational Approaches in Discovery & Design of Antimicrobial Peptides. Basel, Suiça: MDPI. 2023. Publicado • 10.3390/books978-3-0365-7960-3 • Editor González-Díaz, H; Agüero-Chapin, G; Munteanu, C; Prado-Prado, F.J; Chou, Kuo-Chen; Patlewicz, G; López-Díaz, A. Alignment-free models in plant genomics: Theoretical, experimental, and legal issues. New York, Estados Unidos: Nova Science Publisher. 2010. Publicado
Poster em conferência	Agüero-Chapin, G. "Virtual proteolysis strategy to explore the repertoire of antimicrobial peptides from Cnidaria". Trabalho apresentado em Investigação Jovem da U.Porto – IJUP (17 ed.), 2024. Agüero-Chapin, G. "ProtDCal aplicación 3: Desarrollo de modelos de identificación de enzimas mediante nuevos descriptores 3D de proteínas.". Trabalho apresentado em VI International Symposium of Chemistry, Villa Clara. Cuba, 2016.
Pré-impressão	Dany Domínguez-Pérez; Guillermin Agüero-Chapin; Serena Leone; Maria Vittoria Modica. "SeqLengthPlot: An easy-to-use Python-based Tool for Visualizing and Retrieving Sequence Lengths from fasta files with a Tunable Splitting Point". 2024. https://doi.org/10.1101/2024.06.07.597948. 10.1101/2024.06.07.597948 Daniela De Llano García; Yovani Marrero-Ponce; Guillermin Agüero-Chapin; Francesc J. Ferri; Agostinho Antunes; Felix Martinez-Rios; Hortensia María Rodríguez-Cabrera. "Innovative Alignment-Based Method for Antiviral Peptide Prediction". 2024. https://doi.org/10.20944/preprints202407.1476.v1. 10.20944/preprints202407.1476.v1 Guillermin Agüero-Chapin; Agostinho Antunes; José R. Mora; Noel Pérez; Ernesto Contreras-Torres; José R. Valdes-Martini; Felix Martinez-Rios; Cesar H. Zambrano; Yovani Marrero-Ponce. "Complex Networks Analyses of Antibiofilm Peptides: An Emerging Tool for Next Generation Antimicrobials Discovery". 2023. https://doi.org/10.20944/preprints202303.0193.v1. 10.20944/preprints202303.0193.v1 Kevin Castillo-Mendieta; Guillermin Agüero-Chapin; Nelson Santiago Vispo; Edgar A. Márquez; Yunierkis Perez-Castillo; Stephen J. Barigye; Yovani Marrero-Ponce. "Peptide Hemolytic Activity Analysis using Visual Data Mining of Similarity-based Complex Networks". 2023. https://doi.org/10.20944/preprints202303.0322.v1. 10.20944/preprints202303.0322.v1 Castillo-Mendieta, Kevin; Agüero-Chapin, G; Marquez, Edgar A.; Perez-Castillo, Yunierkis; Barigye, Stephen J.; Pérez-Cárdenas, Mariela; Peréz-Giménez, Facundo; Marrero-Ponce, Yovani. Autor correspondente: Marrero-Ponce, Yovani. "A New Robust Method for Predicting Hemolytic Toxicity from Peptide Se-quence". 2023. http://dx.doi.org/10.26434/chemrxiv-2023-1zqzf. 10.26434/chemrxiv-2023-1zqzf Guillermin Agüero-Chapin; Dany Domínguez-Pérez; Yovani Marrero-Ponce; Kevin Castillo-Mendieta; Agostinho Antunes. "Unveiling Encrypted Antimicrobial Peptides from Cephalopods' Salivary Glands: A Proteolysis-Driven Virtual Approach". 2023. https://doi.org/10.26434/chemrxiv-2023-rqqqb. 10.26434/chemrxiv-2023-rqqqb Ayala-Ruano, Sebastián; Marrero-Ponce, Yovani; Aguilera-Mendoza, Longendri; Pérez, Noel; Agüero-Chapin, Guillermin; Antunes, Agostinho; Aguilar, Ana Cristina. "Exploring the Chemical Space of Antiparasitic Peptides and Discovery of New Promising Leads through a Novel Approach based on Network Science and Similarity Searching". 2022. http://dx.doi.org/10.26434/chemrxiv-2021-tgv69-v2. 10.26434/chemrxiv-2021-tgv69-v2 Maylin Romero; Yovani Marrero-Ponce; Hortensia Rodríguez; Guillermin Agüero-Chapin; Agostinho Antunes; Longendri Aguilera-Mendoza; Felix Martinez-Rios. "A Novel Network Science and Similarity Searching-Based Approach for Discovering Potential Tumor Homing Peptides from Antimicrobials". 2022. https://doi.org/10.20944/preprints202202.0046.v1. 10.20944/preprints202202.0046.v1
Tese / Dissertação	Chapin, Guillermin. "A Graphical and Numerical Approach for Functional Annotation and Phylogenetic Inference". Doutoramento, Universidade do Porto Faculdade de Ciências, 2013. https://repositorio-aberto.up.pt/bitstream/10216/69300/2/24615.pdf.

Outros

Outra produção

Sequence Diversity Analysis - SeqDivA version 1.0 (software). SeqDivA is a python-based tool with a friendly GUI designed for Linux and Mac OS. It runs alignment algorithms (water, needle, and blast) to compare all-vs.-all protein, DNA, and RNA sequences.. 2019. Ancede-Gallardo, E; Agüero-Chapin, G. https://github.com/eancedeg/SeqDivA.
ShadowCaster: compositional methods under the shadow of phylogenetic models for the detection of horizontal gene transfer events in prokaryotes (Software).. ShadowCaster is a hybrid approach that sequentially combines a parametric method that incorporates two types of compositional features (k-mers and codon usage) under the shadow of an implicit phylogenetic model built on the basis that the number of orthologs shared between two species is a proxy of the phylogenetic distance.. 2019. Agüero-Chapin, G; Sánchez-Rodríguez, A. http://dx.doi.org/10.1101/684704.
10.1101/684704
Sequencevectorization Phylogenetic Analysis (SVPhylA 2.0) - Software. SVPhylA is a python tool for the calculation of several alignment-free distances for phylogenetics analysis from the most popular alignment-free approaches. Such alignment-free distances are combined into a consensus/compromise matrix by usingalgorithms like DISTATIS based on Multidimensional Scaling (MSD), LinealPrincipal Component Analysis (PCA) and PCA-Kernel (non-lineal).. 2019. Molina-Ruiz, Reinaldo; Agüero-Chapin, G; Sánchez-Rodríguez, A. https://sourceforge.net/projects/svphyla/.
BigD_ProtDescriptors 2.0 (Big Data for Protein Descriptors Calculations) - Software. This sofware is written on the Big Data PySpark platform for the massive calculation of alignment-free protein descriptors and pairwise similarity/distance metrics.. 2019. Molina-Ruiz, Reinaldo; Galpert Cañizares, D; Agüero-Chapin, G. Not public available until publication.
Software: TI2BioP (Topological indices tobiopolymers) version 3.0 (latest). TI2BioP software allows mainly the calculation oftopological indices (spectral moments) derived from inferred and artificial 2Dstructures of DNA, RNA and proteins being possible to carry out a structure-function correlation irrespective of sequence alignments. TI2BioP version 3.0 is a python platform with a graphical interface designed for Linux OS. https://sourceforge.net/projects/ti2biop/.. 2019. Molina-Ruiz, Reinaldo; Agüero-Chapin, G. https://sourceforge.net/projects/ti2biop/.
Software: Sequence vectorization Phylogenetic Analysis (SVPhylA 2.0). SVPhylA is a python tool for the calculation of several alignment-free distances for phylogenetics analysis from the most popular alignment-free approaches. Such alignment-free distances are combined into a consensus/compromise matrix by using algorithms like DISTATIS based on Multidimensional Scaling (MSD), Lineal Principal Component Analysis (PCA) and PCA-Kernel (non-lineal).. 2019. Molina-Ruiz, Reinaldo; Agüero-Chapin, G. https://sourceforge.net/projects/svphyla/.
Software: BigD_ProtDescriptors 2.0 (Big Data for Protein Descriptors Calculations). This sofware is written on the Big Data PySpark platform for the massive calculation of alignment-free protein descriptors. 2019. Molina-Ruiz, Reinaldo; Agüero-Chapin, G.
TI2BioP (Topological indices to biopolymers) version 2.1 - Software. TI2BioP software allows mainly the calculation of topological indices (spectral moments) derived from inferred and artificial 2D structures of DNA, RNA and proteins being possible to carry out a structure-function correlation irrespective of sequence alignments. TI2BioP version 2.1 is a python platform with a graphical interface designed for Linux OS.. 2017. Molina-Ruiz, R; Agüero-Chapin, G; Pérez González, M. https://sourceforge.net/projects/ti2biop/.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2023/05/17	Webinar: Integration of Artificial Intelligence-based Tools into Biodiscovery of AMPs with Antibiotic Potential from Cephalopods.	Seminars of Advanced Studies on Molecular Design and Bioinformatics. Universidad San Francisco de Quito (Quito, Equador)
2022/05	Hands-on training sessions for undergraduate students from the University of Porto (Portugal) and the Universidad San Francisco de Quito and Yachay Tech University in Ecuador. Training focused on equipping students with essential skills in utilising bioinformatics tools for sequence analyses.	Seminars of Advanced Studies on Molecular Design and Bioinformatics. (Porto, Portugal)
2019/09	BigDataProtDescriptors, pHCode: High Performance Computer and Spark paradigm in the efficient manipulation of biomolecules.	SIGESTIC’ 2019 BioCubaFarma (Varadero, Cuba)
2015/10/27	Evaluación de algoritmos supervisados y no supervisados de detección de genes ortólogos manejando el desbalance de los datos.	XIII Congreso Nacional de Reconocimiento de Patrones (RECPAT 2015) (Santiago de Cuba, Cuba)
2013/06/06	A Computational Chemistry Approach for ITS2 Annotation and Phylogenetic Inference.	V International Symposium on Chemistry Universidad Central de Las Villas - Sociedad Cubana de Química (Santa Clara, Cuba)
2013/03/19	An alignment-free approach for eukaryotic ITS2 annotation and phylogenetic inference	International Work-Conference on Bioinformatics and Biomedical Engineering (IWBBIO) IEEE (Granada, Espanha)
2013/03/14	An alignment-free approach for eukaryotic ITS2 annotation and phylogenetic inference	ISCB Africa ASBCB Conference on Bioinformatics (2013) African Society for Bioinformatics and Computational Biology (Casablanca, Marrocos)
2013/02/20	TI2BioP: Topological Indices to Biopolymers. Its practical use to unravel cryptic bacteriocin-like domains.	2nd BioSyst. EU (2013) Federation of European Biological Systematic Societies (Vienna, Áustria)
2011/07	Alignment-free Models supported on the TI2BioP methodology to Identify RNase III Protein Members.	8th Seminars of Advanced Studies on Molecular Design and Bioinformatics. Universidad de La Habana (Havana, Cuba)
2011/05	Péptidos No ribosomales y sus sintetasa: genes y productos	1er Congreso Multidisciplinario de las Ingenierías (Morelia, México)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2022 - Atual	Sea venoms: molecular and ecological innovations of cnidarians and mollusks Coorientador de Alexandre Abreu Barroso	Biologia (Doutoramento) Universidade do Porto Faculdade de Ciências, Portugal
2021/09 - Atual	Protein Structural Classes Identification with AI Combining Alignment-based and Alignment-free Protein Features Coorientador	Computational Intelligence (Doutoramento) Universidad de Granada Departamento de Ciencias de la Computación e Inteligencia Artificial, Espanha
2022/10 - 2023/06	In Silico Discovery of Hemolytic Peptides Through a Novel Approach Based on Network Science and Similarity Searching Methods. Orientador de Kevin Castillo Mendieta	Bachelor in Biology Sciences (Licenciatura/Bacharelato) Yachay Tech University, Equador
2019/09/01 - 2021/11/09	Functional classification of enzymes using semi-supervised learning and Apache Spark Coorientador	Master in Computer Science (Mestrado) Universidad Central Marta Abreu de las Villas Facultad de Matemática Física y Computación, Cuba
2014/01 - 2016/07	Contribuciones al enfoque de comparación par a par en la detección de genes ortologos. Coorientador	Ciencias Técnicas (Doutoramento) Universidad Central Marta Abreu de las Villas, Cuba
2011/09 - 2012/07	Caracterización de secuencias de ADN y proteínas a través del cálculo de los momentos espectrales Orientador de Antonio Bouza Pérez	Licenciatura en Ciencia de la Computación (Licenciatura/Bacharelato) Universidad Central Marta Abreu de las Villas, Cuba
2009/09 - 2010/07	Desarrollo y Aplicación de la metodología TI2BioP a la identificación de proteínas tipo bacteriocinas Orientador de Maylín Rodríguez Pérez	General Biochemistry (Mestrado) Instituto Superior de Ciencias Médicas de Villa Clara Dr Serafín Ruíz Facultad de Estomatologia de Villa Clara, Cuba
2004/10 - 2005/07	Estudio de alternativas para la obtención de bioetanol a partir de bagazo de caña. Coorientador de Naudys Garcia Navarro	Ingeniería Química (Licenciatura/Bacharelato) Universidad Central Marta Abreu de las Villas, Cuba

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2023/01 - 2023/12	Chairperson of the Session BIOMODE.ECO-08: Biotechnology, Molecular Engineering, Natural Products Development, and Ecology Congress, From Forest to Oceans. Paris, France - Ohio, USA, 2023 . MOL2NET 2023 Conference on Molecular, Biomed, Comput. & Network Science and Engineering, 9th ed. (2023/01 - 2023/12) Conferência (Membro da Comissão Organizadora)	Multidisciplinary Digital Publishing Institute AG, Suiça Ikerbasque, Espanha
2022/01 - 2022/12	Chairperson of the Session MODECO-07, Molecular Sciences, Development, Environmental Sustainability, and Economy Congress, From Amazon to Oceans, Paris, France, EPA, USA,, 2022 . MOL2NET 2022, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 8th ed. (2022/01 - 2022/12) Conferência (Membro da Comissão Organizadora)	Multidisciplinary Digital Publishing Institute AG, Suiça Ikerbasque, Espanha
2021/01/25 - 2022/01/30	Chairperson of the Session 06 . BIOMEDIT-02; ITCs & Biomol. Biomed. Eng. Works., Lund, Sweden-Chengdu, China-New Orleans, USA, 2021 . MOL2NET 2021, International Conference on Multidisciplinary Sciences, 7th edition. (2021/01/30 - 2022/01/30) Conferência (Membro da Comissão Organizadora)	Multidisciplinary Digital Publishing Institute AG, Suiça
2020/01/30 - 2021/01/30	Session Chair in MOL2NET-06, International Conference on Multidisciplinary Sciences, ISSN: 2624-5078, MDPI SciForum, Basel, Switzerland, 2020 - Session 06. MODECO-05: Molec. Diversity, Energy, & Ecosystems, Puyo, Ecuador-Porto, Portugal-Paris, France, EPA, USA, 2020 (2020/01 - 2021/01) Conferência (Membro da Comissão Organizadora)	Multidisciplinary Digital Publishing Institute AG, Suiça

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2024/09 - Atual	Blue Think Conference (Porto, CIIMAR-2024). In silico proteolysis approach to uncover the repertoire of antimicrobial peptides from Cnidaria. Alexandre Barroso, Guillermin Agüero-Chapin, Rita Sousa and Agostinho Antunes. Conferência	Blue Think Conference 2024 Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2024/05 - Atual	Investigação Jovem da U.Porto – IJUP (17 ed.) . Virtual proteolysis strategy to explore the repertoire of antimicrobial peptides from Cnidaria. Rita Sousa, Alexandre Barroso, Guillermin Agüero-Chapin and Agostinho Antunes. Conferência	Investigação Jovem da U.Porto – IJUP (17 ed.) Universidade do Porto Faculdade de Ciências, Portugal
2024/03/20 - 2024/03/22	Poster Presentation "In Silico Discovery of Hemolytic Peptides Through a Novel Approach Based on Network Science and Similarity Searching Methods" Conferência	The 1st International Electronic Conference on Toxics Multidisciplinary Digital Publishing Institute AG, Suiça
2020/09/17 - 2020/09/17	Blue Think Conference (Porto, CIIMAR-2020). Three Ascidians Tunic from a Metaproteomic Perspective. Ana Matos, Dany Domínguez-Pérez, Daniela Almeida, Guillermin Agüero-Chapin, Alexandre Campos, Hugo Osório, Vitor Vasconcelos and Agostinho Antunes Conferência	Blue Think Conference - FIRST CIIMAR STUDENTS' MEETING (BTC-2020) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2018/09/09 - 2018/09/12	From Metabarcoding to Metagenomics: Unraveling the evolutionary genomics of host-microbe interactions and search for potential secondary metabolites (Poster). Authors: Anoop Alex, Guillermin Agüero Chapin, Agostinho Antunes. Congresso	31st Congress ESPB -European Society for Comparative Physiology & Biochemistry Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2018/06 - 2018/08/01	Surveying Alignment-free Features for Ortholog Detection in Related Yeast Proteomes by using Supervised Big Data Classifiers (doi: 10.3390/mol2net-04-05468; Conference Paper). Authors: Deborah Galpert Cañizares; Alberto Fernández; Francisco Herrera; Agostinho Antunes; Reinaldo Molina Ruiz; Guillermin Agüero-Chapin. Conferência	Proceedings of MOL2NET 2018, International Conference on Multidisciplinary Sciences, 4th edition Ikerbasque, Espanha Multidisciplinary Digital Publishing Institute AG, Suiça Universidad del País Vasco Facultad de Ciencia y Tecnología, Espanha
2016/09/18 - 2016/09/23	Exploring the toxin expression in the Harderian gland’s transcriptome of three Cuban snakes (Colubroidea) (Poster) Authors: Dany Domínguez-Pérez, Jordi Durban, Guillermin Agüero-Chapin, Javier Torres Lopez, Reinaldo Molina Ruiz, Bruno Reis, Juan Calvete, Vítor Vasconcelos and Agostinho Antunes Congresso	XII Congress of the Pan American Section of the International Society on Toxinology International Society on Toxinology, Estados Unidos
2016/06/07 - 2016/06/10	Topological Indices to Biopolymers (TI2BioP) and Sequence Vectorization for Phylogenetic Analysis (SVPhyLA). Graphical-Numerical tools for Sequence Encoding (Poster) Authors: Reinaldo Molina, Evys Ancede, Guillermin Agüero, Gisselle Pérez, Agostinho Antunes Simpósio	VI International Symposium of Chemistry (SIQ 2016) Universidad Central Marta Abreu de las Villas, Cuba Sociedad Cubana de Química, Cuba
2015/12/05 - 2015/12/15	Pairwise Ortholog Detection in Related Yeast Species by Using Big Data Supervised Classifications (doi:10.3390/MOL2NET-1-e002; Conference paper). Authors: Galpert Cañizares, D.; del Río García, S.; Herrera, F.; Ancede Gallardo, E.; Antunes, A.; Agüero-Chapin, G. Conferência	Proceedings of MOL2NET 2015, International Conference on Multidisciplinary Sciences Multidisciplinary Digital Publishing Institute AG, Suiça Universidad del País Vasco Facultad de Ciencia y Tecnología, Espanha Ikerbasque, Espanha
2015/12/05 - 2015/12/15	TI2BioP: Topological Indices to BioPolymers (doi:10.3390/MOL2NET-1-F011; Conference paper). Authors: Agüero-Chapin, G.; Molina Ruiz, R.; Antunes, A. Conferência	Proceedings of MOL2NET 2015, International Conference on Multidisciplinary Sciences Ikerbasque, Espanha Multidisciplinary Digital Publishing Institute AG, Suiça Universidad del País Vasco Facultad de Ciencia y Tecnología, Espanha
2015/11/25 - 2015/11/27	Esquema de evaluación de algoritmos supervisados y no supervisados de detección de genes ortólogos en levaduras Saccharomycete manejando el desbalance de los datos. Companioni Brito, C.; Galpert Cañizares, D.; Ancede Gallardo, E.; Antunes, A.; Agüero-Chapin, G. Congresso	Congreso Internacional de la Sociedad Cubana de Matemática y Computación Universidad de la Habana, Cuba
2015/06/26 - 2015/06/30	Alignment-free methods for the detection and specificity prediction of Adenylation domains (Poster). Agostinho Antunes, Guillermin Agüero-Chapin, Gisselle Pérez-Machado, Aminael Sánchez-Rodríguez and Miguel Santos. Encontro	Evolution 2015 American Society of Naturalists, Estados Unidos Society of Systematic Biologists, Estados Unidos
2014/12/03 - 2014/12/05	Exploring Adenylation Domains Repertoire Of Nonribosomal Peptide Synthetases Using Four-Color Maps (Poster Presentation). Authors: Guillermin Aguero, Reinaldo Molina, Gisselle Perez, Agostinho Antunes Conferência	21 Conferencia de Química Universidad de Oriente, Cuba Sociedad Cubana de Química, Cuba
2011/06/12 - 2011/06/15	Alignment-free Models based on the TI2BioP methodology to identify Rnase III protein members (Poster). Guillermin Agüero-Chapin, Gustavo A de la Riva, Reinaldo Molina-Ruiz, Aminael Sánchez-Rodríguez, Gisselle Pérez-Machado, Vítor Vasconcelos and Agostinho Antunes Encontro	2nd Iberic Meeting on Medicinal Chemistry Universidade do Porto, Portugal
2010/10/13 - 2010/10/15	Comparative enzymatic activity of three recombinant RNAse III and effect of bacterial RNAse III expressed in transformed yeasts (Poster). Authors: de la Riva G.A, Agüero–Chapin G, Morales-Aragón JC, Pérez-Machado G, Vasconcelos V and Antunes A Congresso	3er Congreso Internacional de Investigación CIPITECH Instituto Tecnológico de Parral, México
2010/09/19 - 2010/09/24	A general QSAR methodology to predict telomerase inhibition by G-quadruplex stabilization (Poster). Authors: Castillo-González Daimel, Perez-Machado Gisselle, Agüero-Chapin Guillermin, Morales-Helguera Aliuska, Teijeira-Bautista Marta, Cabrera-Perez Miguel Angel Simpósio	18th European Symp osium on Quantitative Structure–Activity Relationships -EuroQSAR (2010) “Discovery Informatics & Drug Design” (Rhodes, Greece) European Federation for Medicinal Chemistry, Itália
2010/06/01 - 2010/06/04	A QSFR-like model to detect proteinaceous bacteriocins. Its practical application to the discovery of new bacteriocin-like domains (Poster). Authors: Guillermin Agüero-Chapin, Gisselle Pérez-Machado, Reinaldo Molina-Ruiz, Yunierkis Pérez-Castillo, Aliuska Morales-Helguera, Victor Vasconcelos and Agostinho Antunes Simpósio	IV International Symposium on Chemistry Universidad Central Marta Abreu de las Villas, Cuba Sociedad Cubana de Química, Cuba
2009/11/09 - 2009/11/13	QSAR study to polymeric sequences embedded in a novel 2D lattice. "Sesión Omica de Plantas." (Poster). Authors: Guillermin Agüero Chapin, Humberto González-Díaz, Gustavo A de La Riva, Gisselle Pérez-Machado, Agostinho Antunes Congresso	XIII Congreso Nacional de Bioquímica y Biología Molecular de Plantas Centro de Investigación y de Estudios Avanzados Unidad Irapuato, México
2009/11/02 - 2009/11/05	Telomerase inhibitors by G-quadruplex stabilization: A QSAR approach (Poster). Authors: Daimel Castillo González, Miguel Ángel Cabrera Pérez, Gisselle Pérez Machado, Guillermin Agüero Chapin, Aliuska Morales Helguera Congresso	Biotecnología Habana 2009 "Aplicaciones Médicas de la Biotecnología" Centro de Ingenieria Genetica y Biotecnologia, Cuba
2009/07/17 - 2009/07/20	A new approach of the sub-structural analysis toward the design of A1 Adenosine Receptors Agonists (Conference paper). Authors: Marta Teijeria Bautista, Maykel Pérez González, Aliuska Morales Helguera, Guillermin Agüero Chapin, Gisselle Pérez Machado, Carmen Terán Moldes. Encontro	Third Join Italian-German Purine Club Meeting Purinergic Receptors. "New Frontiers for Novel Therapies" Università degli Studi di Camerino, Itália European Federation for Medicinal Chemistry, Itália
2007/06/05 - 2007/06/08	Computacional design of cellulolytics complexes for improving enzymatic hydrolysis in ethanol production (Poster). Authors: Guillermin Agüero Chapin, Humberto González-Díaz, Gustavo A de La Riva, Agostinho Antunes. Simpósio	III Simposio Internacional de Química Universidad Central Marta Abreu de las Villas, Cuba Sociedad Cubana de Química, Cuba
2005/12/07 - 2005/12/09	"Study of bagasse hydrolysis using concentrated sulfuric acid for etanol obtaining and technical-economical analysis of this process" (Chemical Engineering Workshop) - "2D RNA-QSAR: assigning ACC oxidase family membership with stochastic molecular descriptors; isolation and prediction of a sequence from Psidium guajava L" (Bioinformatics Workshop) Conferência	18 International Conference of Chemistry Universidad de Oriente Departamento de Química, Cuba Sociedad Cubana de Química, Cuba
2004/11/18 - 2004/11/22	"Isolation of a ACC Oxidase cDNA fragment expressed during Dwarf Guava’s (Psidium guajava L) fruit ripening" (Poster). Authors: Guillermin Agüero, Edrey Rodríguez, Lisbet Diaz, Neyda Bacallao y Elio Jiménez "Study of bagasse hydrolysis using concentrated sulfuric acid for etanol obtaining and technical-economical analysis of this process" (Poster). Authors: Guillermin Agüero, Boutros Fouad Sarrouh, Josefina Jover Conferência	Vl International Conference of Chemistry and Chemical Engineering - II Simposio Internacional de Bioquímica y Biología Molecular Universidad de la Habana Facultad de Biologia, Cuba
2004/06/14 - 2004/06/18	Study of bagasse hydrolysis using concentrated sulfuric acid for etanol obtaining (Poster). Authors: Boutros Fouad Sarrouh, Guillermin Agüero, Josefina Jover and Erenio González Conferência	VIII International Conference on sugar and its derived products “Diversificación 2004” Asociación de Técnicos Azucareros de Cuba, Cuba
2003/06 - 2003/06	"Advances in bioethanol’s production starting from lignocellulosic material" (Poster). Authors: Guillermin Agüero, Josefina Jover, Erenio Suárez "Alternatives for by-products coming from bio-fuel technology obtaining" (Poster). Authors: Leyanis Mesa, Guillermin Agüero, Erenio Suárez Conferência	II Conferencia Internacional de Química Universidad Central Marta Abreu de las Villas, Cuba Sociedad Cubana de Química, Cuba
2002/06 - 2002/06	Isolation of a ACC Oxidase cDNA fragment expressed during Dwarf Guava (Psidium guajava L.) fruit ripening (Poster). Authors: Guillermin Agüero, Edrey Rodríguez, Neyda Bacallao and Elio Jiménez Encontro	6th Coloquio Internacional de Biotecnología de las Plantas Universidad Central Marta Abreu de las Villas - Instituto de Biotecnología de las Plantas, Cuba
2001/04/16 - 2001/04/20	Isolation of a ACC Oxidase cDNA fragment expressed during Dwarf Guava ( Psidium guajava L.) fruit ripening (Poster) Congresso	Congreso Internacional de Biotecnología de las Plantas, BioVeg 2001 Universidad de Ciego de Avila, Cuba
1999/06/16 - 1999/06/19	"Studies of parameters affecting genetic transformation of banana somatic embryos cv. Gran Enano by gene gun" (Poster) "The inmunopotenciar properties characterization of the Cry 1Ac toxin: possible use of these proteins as adjuvant source in the oral-vaccines preparation" (Poster) Simpósio	5to Coloquio Internacional de Biotecnología Vegetal Universidad Central Marta Abreu de las Villas - Instituto de Biotecnología de las Plantas, Cuba

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2023/05	Identification of epigenetic mechanisms related to immunosuppression phenomena in sepsis and their use as prognostic biomarkers. Vogal	REBECA OSCA VERDEGAL (Doutoramento) Universitat de València Facultat de Medicina i Odontologia, Espanha
2022/11	Deep Learning applications over Heterogeneous Networks: from Multimedia to Genes. Arguente	Jesús Fernando Cevallos Moreno (Doutoramento) Dipartimento di Ingegneria Informatica Automatica e Gestionale, SAPIENZA – Università di Roma, Itália
2022/01/20	Use of circulating histones and their post-translational modifications as biomarkers in sepsis and septic shock. Vogal	Jesús Beltrán García (Doutoramento) Universitat de València Facultat de Medicina i Odontologia, Espanha
2021/11/30	Ecophysiological and transcriptomic response of two intertidal mollusc species to thermal stress Arguente principal	Harold Casalís Cantalló (Mestrado) Universidade de Aveiro, Portugal
2015	Development of reductionist energy models applied to the folding of globular proteins and their generalization into protein descriptors. Arguente principal	Yasser Ruiz-Blanco (Doutoramento) Universidad Central Marta Abreu de las Villas, Cuba

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2023/01 - 2023/12	NICE.XSM-09: North-Ibero-America Congress on EXperimental & Simulation Methods, Valencia, Bilbao, Spain - Miami, USA, MOL2NET 2023	University of Valencia, Spain; Miami Dade College, USA; Tulane University, USA.
2022/01 - 2022/12	MOL2NET'22, Conference on Molecular, Biomedical & Computational Sciences and Engineering, 8th ed	Multidisciplinary Digital Publication Institute (MDPI)
2020/01/30 - 2021/01/30	Workshop Series on Nanotechnology and Material Sciences (NANOBIOMATJND), Jackson State University (JSU) and North Dakota State University (NDSU), USA	MOL2NET 2020, International Conference on Multidisciplinary Sciences, 6th edition
2020/01/30 - 2021/01/30	USEDAT: USA-Europe Data Analysis Training Program Workshop, UPV/EHU, Bilbao, Basque Country-MDC, Miami, USA, 2020	MOL2NET 2020, International Conference on Multidisciplinary Sciences, 6th edition
2020/01/30 - 2021/01/30	USINEWS-04: US-IN-EU Worldwide Science Workshop Series, UMN, Duluth, USA, 2020	MOL2NET 2020, International Conference on Multidisciplinary Sciences, 6th edition
2020/01/30 - 2021/01/30	BIOMEDIT-01; BioMedical & Information Technologies Worldwide Workshop, Chengdu, China, 2020	MOL2NET 2020, International Conference on Multidisciplinary Sciences, 6th edition
2020 - 2021	IWIMSM-04: Iberoamerican Workshop on Model. and Simulation Methods, Valencia, Spain, 2020	MOL2NET 2020, International Conference on Multidisciplinary Sciences, 6th edition

Arbitragem científica em revista

	Nome da revista (ISSN)	Editora
2024/10/04 - Atual	Frontiers in Microbiology (Guest Editor) (1664-302X)	Frontiers
2024/09 - Atual	Toxins (Guest Editor) (2072-6651)	MDPI
2023/10 - Atual	Antibiotics (Guest Editor) (2079-6382)	MDPI
2020/11 - Atual	Antibiotics (Topic Board) (2079-6382)	MDPI AG
2020/08 - Atual	Marine Drugs (Reviewer Board) (1660-3397)	MDPI AG
2022/11/01 - 2024/11/30	Frontiers in Bioinformatics (Guest Editor) (2673-7647)	Frontiers
2021/09/27 - 2023/12	Antibiotics (Guest Editor) ( 2079-6382)	MDPI
2015 - 2015	Current Topics in Medicinal Chemistry (Guest Editor) (1568-0266)	Bentham Science

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2022/08 - Atual	Concurso - Bolsas de Iniciação à Investigação (BII) -Verão com Ciência Avaliador	Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal	Fundação para a Ciência e a Tecnologia
2024/04/19 - 2024/05/06	Jury Member to Assign two Research Grants in the framework of the project: iCulture - A digital bio-platform and co-culture bioprocess to prospect and utilize macroalgae responsibly and sustainably. Horizon Europe (HE-101082010). Avaliador	Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal	Horizon 2020
2023/08/10 - 2023/08/24	Jury Member to Assign a Research Grant in the framework of the project ¿AFRICoV - Genomic surveillance of SARS-CoV-2(-like) viruses in African bushmeat markets, and perceptions of health risks related to COVID-19 and bushmeat consumption Avaliador	Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal	Agence nationale de la recherche
2021/07/19 - 2021/08/17	Concurso - Bolsas de Iniciação à Investigação (BII) -Verão com Ciência Avaliador	Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal	Fundação para a Ciência e a Tecnologia

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2013 - 2016	Invited Professor in the Master Program Research and Drug Development¿. Subject: Biotechnology Applied to Drug Production.	Research and Drug Development (Master)	Universidad Central Marta Abreu de las Villas - Centro de Bioactivos Químicos, Cuba
2005 - 2008	Professor of Biochemistry in the Chemical Engineering university course	Chemical Engineering (Bachelor)	Universidad Central Marta Abreu de las Villas - CAP/Facultad de Química y Farmacia, Cuba
2003 - 2005	Professor of Biochemistry in the Chemistry university course	Biochemistry (Bachelor)	Universidad Central Marta Abreu de las Villas - CAP/Facultad de Química y Farmacia, Cuba
2002 - 2004	Assistant professor of Microbiology Laboratory in the Chemical Engineering course	Chemical Engineering (University degree) (Bachelor)	Universidad Central Marta Abreu de las Villas - CAP/Facultad de Química y Farmacia, Cuba

Entrevista (jornal / revista)

	Descrição da atividade	Jornal / Forum
2011/12/15	Agostinho Antunes e Guillermin Aguero-Chapin, do Centro Interdisciplinar de Investigação Marinha e Ambiental, Universidade do Porto, desenvolveram com uma equipa de oito cientistas internacionais uma nova metodologia para o estudo de Biopolímeros. Revista Digital Ciencia Hoje (Fonte: https://biologiaesalv12a.blogspot.com/search?q=Guillermin)	Ciência Hoje/cienciahoje.pt (https://biologiaesalv12a.blogspot.com/search?q=Guillermin)

Membro de associação

	Nome da associação	Tipo de participação
2024/01 - Atual	PagBiOmicS: Personalised Academic Guidance and Biodiscovery-integrated OMICs Solutions (https://www.pagbiomics.com).	Co-Founder
2017 - Atual	Ecuatorian Bioinformatics Network	Member
2004 - Atual	Cuban Chemistry Society	Member
2002/09 - Atual	Cuban Society of Pharmacology	Member

Outro júri / avaliação

	Descrição da atividade	Instituição / Organização
2024/05/02 - 2024/05/27	Evaluator for Canadian Poultry Research Council – Internal Funding Program (2024): Chicken proteins derived antimicrobials to Treat S. enteriditis Infection in Laying Hens..	Canadian Poultry Research Council, Canadá Natural Sciences and Engineering Research Council of Canada, Canadá
2014 - 2020	Reviewer of the journals - https://publons.com/researcher/1403725/ (1) Current Bioinformatics (2) Chemical Biology and Drug Design (3) Molecular Biosystem (4) Chemometrics and Intelligent Laboratory Systems (5) Amino Acids (6) BMC Bioinformatics (7) Journal of Proteome Research (8) Computational Biology and Chemistry (9) Current Topics in Medicinal Chemistry (10) Journal of Theoretical Biology (11) Scientific Reports (12) Data (13) Computer Methods and Programs in Biomedicine	Springer International Publishing AG, Suiça Elsevier BV, Países Baixos Biomed Central Ltd, Reino Unido American Chemical Society, Estados Unidos Bentham Science Publishers Ltd, Emiratos Árabes Unidos John Wiley & Sons Inc, Reino Unido Royal Society of Chemistry, Reino Unido Multidisciplinary Digital Publishing Institute AG, Suiça Springer Nature, Luxemburgo
2019/05 - 2019/05	External Evaluator - Internal Projects of Universidad de Las Américas (Ecuador): Descubrimiento de nuevos estabilizadores del cuarteto-G con actividad antitumoral.	Universidad de Las Américas, Equador
2018/11 - 2018/12	External Evaluator of National Projects in Chile: Concurso Nacional de Proyectos FONDECYT (Fondo Nacional de Desarrollo Científico y Tecnológico) Regular 2019.	Comisión Nacional de Investigación Científica y Tecnológica, Chile
2018/05/01 - 2018/05/21	External Evaluator - Internal Projects of Universidad de Las Américas (Ecuador) : Desarrollo e implementación computacional de descriptores moleculares y líneas celulares con su posterior aplicación en diversos problemas biológicos	Universidad de Las Américas, Equador
2016/06 - 2016/08	External Evaluator of National Projects in Ecuador: “Formación del Grupo de Integración de Datos Quimio-Genómicos del Ecuador” for the Red Nacional de Investigación y Educacion del Ecuador (REDCEDIA): Call Name: Concurso Ecuatoriano de Proyectos en Redes Avanzadas - CEPRA 2016.	CEDIA, Equador

Tutoria

	Tópico	Nome do aluno
2024/06/26 - 2024/07/20	Marine Antimicrobial Peptides: Solutions to Antimicrobial Resistance	Celia Caridad Borges Casas
2023/11 - 2024/06	Virtual Proteolysis Strategy to Explore the Repertoire of Antimicrobial Peptides from Cnidaria	Rita Maria Silva de Sousa
2022/11 - 2023/06	Computer-Aided Search for Next Generation Antibiotics from Cephalopods Salivary Glands Proteomes	Júlia Moreira Trancho

Distinções

Prémio

2024	Best Poster Award - The 1st International Electronic Conference on Toxics Multidisciplinary Digital Publishing Institute AG, Suiça
2018	Annual Regional Award (Coauthor). Combinación de medidas de similitud para la detección escalable de genes ortólogos en especies de levaduras. Ministerio de Ciencia Tecnologia y Medio Ambiente, Cuba
2015	Annual Award of the Cuban Academy of Sciences (Main Author). "Métodos grafo-numéricos de relevancia para la bioinformática. Aplicaciones en la biotecnología vegetal y en el descubrimiento de fármácos" Academia de Ciencias de Cuba, Cuba
2013	Annual Regional Award (Main Author) “Development of a graphical and numerical approach for functional annotation and phylogenetic inference in gene/protein families involved in drug discovery” Ministerio de Ciencia Tecnologia y Medio Ambiente, Cuba
2005	Anual Award of the Cuban Academy of Sciences (Collaborator). "From molecular structure biological activity: Applications and potentialities of novel computational design methods in QSAR, QSPR, QSPkR, QSTR studies, proteomic and bioinformatics" Academia de Ciencias de Cuba, Cuba
2002	Premio Alvaro Reynoso Asociación de Técnicos Azucareros de Cuba, Cuba

Outra distinção

2014	Medal of Recognition and Merit for PhD Graduates. Thesis – A Graphical and Numerical Approach for Functional Annotation and Phylogenetic Inference Universidade do Porto Faculdade de Ciências, Portugal
2006	Top-50 most cited article 2005-2008. "Novel 2D maps and coupling numbers for protein sequences. The first QSAR study of polygalacturonases; isolation and prediction of a novel sequence from Psidium guajava L. FEBS Letters 580 (2006)" The Federation of European Biochemical Societies, Reino Unido