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TL Duarte (TLD) graduated in Biology by the University of Lisbon in 2000 and completed an MSc in Molecular Genetics (Distinction) by the University of Leicester (UK) in 2001. In 2007, TLD obtained his PhD from the University of Leicester, for studying the so-called non-antioxidant roles of vitamin C. Between February 2006 and March 2008, TLD was employed as Research Assistant at the University of Leicester, where he supported the University microarray facility and contributed to studies on DNA damage formation and repair. In 2008, TLD joined the Institute for Molecular and Cell Biology (IBMC) - University of Porto as 'Ciência 2007' Research Assistant. TLD demonstrated the crucial hepatoprotectant role of transcription factor NRF2 against iron toxicity in mice, and more recently the ability of NRF2 to sense toxic iron and regulate BMP6/hepcidin signalling. He is currently a Researcher at the Basic and Clinical Research on Iron Biology group (Head: Graça Porto) at IBMC/i3S. Overall, TLD published 1 (invited) book chapter, 3 review articles and 21 original papers in international peer review journals with accumulated >1000 citations. TLD also: obtained ca. 370,000 euros funding as PI; completed the supervision of 10 MSc students; presented orally in several international scientific meetings; contributed regularly to official Doctoral programs of the University of Porto; is member of a scientific society (European Iron Club) and peer reviewer for over 20 journals, including Antioxidants & Redox Signalling, Free Radical Biology and Medicine, Journal of Hepatology, and Redox Biology. TLD is member of the i3S Animal Welfare and Ethics Review Body and Editorial Board member of Antioxdants & Redox Signaling.
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Identificação

Identificação pessoal

Nome completo
Tiago Pereira de Lacerda Costa Duarte

Nomes de citação

  • Duarte, Tiago L

Identificadores de autor

Ciência ID
731C-645C-935A
ORCID iD
0000-0002-4901-4580

Domínios de atuação

  • Ciências Médicas e da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador elementar (A1) Utilizador proficiente (C1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2002 - 2007/07/13
Concluído
 Doctor of Philosophy (Doctor of Philosophy)
University of Leicester, Reino Unido
"EFFECTS OF VITAMIN C ON DNA DAMAGE, IRON HOMEOSTASIS AND GENE EXPRESSION PROFILING IN HUMAN FIBROBLASTS" (TESE/DISSERTAÇÃO)
2000/09 - 2001/07
Concluído
 MSc in Molecular Genetics (Master)
University of Leicester Department of Genetics, Reino Unido
"Investigation of the role of vitamin C in promoting an adaptive response" (TESE/DISSERTAÇÃO)
 Distinction
1995 - 2000
Concluído
 Biologia Aplicada aos Recursos Animais (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Preliminary study of the genetic variability of the different forms of the «Leuciscus alburnoides complex» (Teleostei, Cyprinidae) using microsatellites" (TESE/DISSERTAÇÃO)
 16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/01/01 - Atual Investigador (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2016/01/01 - 2018/12/31 Pós-doutorado (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2015/10/01 - 2015/12/31 Pós-doutorado (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2013/07/01 - 2015/09/30 Investigador Auxiliar Convidado (carreira) (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2008/04/14 - 2013/04/13 Investigador Auxiliar (carreira) (Investigação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2006/02/01 - 2008/03/01 Assistente de Investigação (carreira) (Investigação) University of Leicester, Reino Unido
Projetos

Bolsa

Designação Financiadores
2023/01/02 - Atual The role of the heme-exporter FLVCR1 in hepatocellular carcinoma
2022.03222.PTDC
Investigador responsável
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Em curso
2022/01/17 - 2023/07/16 Bridging iRon metabolism and immunE cells at the irrAdiateD tumOUr microenvironmenT to identify novel therapeutic targets in rectal cancer
EXPL/BIA-CEL/1225/2021
Investigador
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Em curso
2022/01/15 - 2023/07/14 Infection and iron homeostasis: a new perspective for an old question
EXPL/BIA-BQM/1170/2021
Investigador
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Em curso
2022/01/01 - 2023/06/30 The role of endothelial Nrf2 in the vascular niche remodelling induced by acute myeloid leukemia
EXPL/MED-ONC/0522/2021
Investigador
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Em curso
2016/05/01 - 2019/12/31 Structured Programme on Bioengeneering Therapies for Infectious Diseases and Tissue Regeneration
NORTE-01-0145-FEDER-000012
Investigador
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Comissao de Coordenacao e Desenvolvimento Regional do Norte
Concluído
2013/07 - 2015/09 Understanding the contribution of iron overload in non-alcoholic fatty liver disease: identification of cellular players and potential molecular therapeutic targets
Provided by PTCRIS: 125341
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2012/06/01 - 2013/12/31 Is the cytoprotective Nrf2 signalling pathway induced in human blood monocytes from HFE hemochromatosis patients and is there an association with disease penetrance?
PP_IJUP2011 122
Investigador responsável
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Universidade do Porto
Concluído
2010/06 - 2013/06 A role for Nrf2/ARE cytoprotective signalling in iron overload. Adaptive response to oxidative stress as a disease modifier in HFE-associated hereditary hemochromatosis.
Provided by PTCRIS: 101177
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2008/01 - 2010/12 HFE as a multitask protein: genomic and biochemical analysis
Provided by PTCRIS: 66818
Investigador
Fundação para a Ciência e a Tecnologia, I.P.

Projeto

Designação Financiadores
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 2 - 2011-2012
PEst-C/SAU/LA0002/2011
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008/01/01 - 2010/12/31 HFE: análise genómica e bioquímica de uma proteína multifuncional
PTDC/BIA-BCM/66818/2006
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Duarte, Tiago L; Nicole Viveiros; Catarina Godinho; Delfim Duarte. Autor correspondente: Duarte, Tiago L. "Heme (dys)homeostasis and liver disease". Frontiers in Physiology 15 (2024): https://doi.org/10.3389/fphys.2024.1436897.
    Acesso aberto • Publicado • 10.3389/fphys.2024.1436897
  2. Tiago L. Duarte; Marta Lopes; Mónica Oliveira; Ana G. Santos; Catarina Vasco; Joana P. Reis; Ana Rita Antunes; et al. "Iron overload induces dysplastic erythropoiesis and features of myelodysplasia in Nrf2-deficient mice". Leukemia (2024): https://doi.org/10.1038/s41375-023-02067-9.
    10.1038/s41375-023-02067-9
  3. Diogo Estêvão; Miguel da Cruz-Ribeiro; Ana P. Cardoso; Ângela M. Costa; Maria J. Oliveira; Tiago L. Duarte; Tânia B. da Cruz. "Iron metabolism in colorectal cancer: a balancing act". Cellular Oncology (2023): https://doi.org/10.1007/s13402-023-00828-3.
    10.1007/s13402-023-00828-3
  4. Estêvão, Diogo; da Cruz-Ribeiro, Miguel; Cardoso, Ana Patrícia; Costa, Ângela; Maria José Oliveira; Duarte, Tiago L; Cruz, Tânia. Autor correspondente: Cruz, Tânia. "Iron metabolism in colorectal cancer: a balancing act". Cellular Oncology (2023):
    Aceite para publicação
  5. Pinto, Ana Teresa; Machado, Ana Beatriz; Osório, Hugo; Pinto, Marta Laranjeiro; Vitorino, Rui; Justino, Gonçalo; Santa, Cátia; et al. "Macrophage Resistance to Ionizing Radiation Exposure Is Accompanied by Decreased Cathepsin D and Increased Transferrin Receptor 1 Expression". Cancers 15 1 (2022): 270. http://dx.doi.org/10.3390/cancers15010270.
    Acesso aberto • Publicado • 10.3390/cancers15010270
  6. Coutinho, Maria P.; Teles, Maria José; Melo, Graça; Lopes, Marta; Duarte, Delfim; Duarte, Tiago L.; Reis, Júlia; et al. "Ferritin Increase in Hemochromatosis Subjects After Discontinuing Their Regular Maintenance Treatment: A Longitudinal Analysis Performed During the COVID-19 Imposed Hospital Lockdown". HemaSphere 6 9 (2022): e770. http://dx.doi.org/10.1097/hs9.0000000000000770.
    Acesso aberto • Publicado • 10.1097/hs9.0000000000000770
  7. Duarte, Tiago L.; Neves, João V.. Autor correspondente: Duarte, Tiago L.. "Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay". Journal of Visualized Experiments 179 (2022): http://dx.doi.org/10.3791/63469.
    Publicado • 10.3791/63469
  8. Marta Lopes; Tiago L. Duarte; Maria J. Teles; Laura Mosteo; Sérgio Chacim; Eliana Aguiar; Joana Pereira-Reis; et al. "Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications". Blood Advances (2021): https://doi.org/10.1182/bloodadvances.2021004373.
    10.1182/bloodadvances.2021004373
  9. Ferreira, A.V.; Duarte, T.L.; Marques, S.; Costa, P.; Neves, S.C.; Santos, T. dos; Granja, P.L.; Porto, G.. "Iron triggers the early stages of cartilage degeneration in vitro: the role of articular chondrocytes". Osteoarthritis and Cartilage Open (2021): 100145. http://dx.doi.org/10.1016/j.ocarto.2021.100145.
    Acesso aberto • No prelo • 10.1016/j.ocarto.2021.100145
  10. Frost, Joe N.; Tan, Tiong Kit; Abbas, Munawar; Wideman, Sarah K.; Bonadonna, Michael; Stoffel, Nicole U.; Wray, Katherine; et al. "Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection". Med (2020): http://dx.doi.org/10.1016/j.medj.2020.10.004.
    Acesso aberto • Publicado • 10.1016/j.medj.2020.10.004
  11. Duarte, Tiago L.; Talbot, Nick P.; Drakesmith, Hal. "NRF2 and Hypoxia-Inducible Factors: Key Players in the Redox Control of Systemic Iron Homeostasis". Antioxidants & Redox Signaling (2020): http://dx.doi.org/10.1089/ars.2020.8148.
    Acesso aberto • 10.1089/ars.2020.8148
  12. Pei Jin Lim; Tiago L. Duarte; João Arezes; Daniel Garcia-Santos; Amel Hamdi; Sant-Rayn Pasricha; Andrew E. Armitage; et al. "Nrf2 controls iron homoeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin". Nature Metabolism (2019): https://doi.org/10.1038/s42255-019-0063-6.
    10.1038/s42255-019-0063-6
  13. Sant-Rayn Pasricha; Pei Jin Lim; Tiago L. Duarte; Carla Casu; Dorenda Oosterhuis; Katarzyna Mleczko-Sanecka; Maria Suciu; et al. "Hepcidin is regulated by promoter-associated histone acetylation and HDAC3". Nature Communications 8 1 (2017): https://doi.org/10.1038/s41467-017-00500-z.
    10.1038/s41467-017-00500-z
  14. Duarte, T.L.; Caldas, C.; Santos, A.G.; Silva-Gomes, S.; Santos-Gonçalves, A.; Martins, M.J.; Porto, G.; Lopes, J.M.. "Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis". Redox Biology 11 (2017): 157-169. http://www.scopus.com/inward/record.url?eid=2-s2.0-85002982394&partnerID=MN8TOARS.
    10.1016/j.redox.2016.11.013
  15. Almeida, I. F.; Pinto, A. S.; Monteiro, C.; Monteiro, H.; Belo, L.; Fernandes, J.; Bento, A. R.; et al. "Protective effect of C-sativa leaf extract against UV mediated-DNA damage in a human keratinocyte cell line". Journal of Photochemistry and Photobiology B-Biology 144 (2015): 28-34. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000351800900005&KeyUID=WOS:000351800900005.
    10.1016/j.jphotobiol.2015.01.010
  16. Chambel, S.S.; Santos-Gonçalves, A.; Duarte, T.L.. "The dual role of Nrf2 in nonalcoholic fatty liver disease: Regulation of antioxidant defenses and hepatic lipid metabolism". BioMed Research International 2015 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84930625964&partnerID=MN8TOARS.
    10.1155/2015/597134
  17. Silva-Gomes, S.; Santos, A.G.; Caldas, C.; Silva, C.M.; Neves, J.V.; Lopes, J.; Carneiro, F.; Rodrigues, P.N.; Duarte, T.L.. "Transcription factor NRF2 protects mice against dietary iron-induced liver injury by preventing hepatocytic cell death". Journal of Hepatology 60 2 (2014): 354-361. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892559263&partnerID=MN8TOARS.
    10.1016/j.jhep.2013.09.004
  18. Duarte, T.L.; Cooke, M.S.; Jones, G.D.D.. "Gene expression profiling reveals new protective roles for vitamin C in human skin cells". Free Radical Biology and Medicine 46 1 (2009): 78-87. http://www.scopus.com/inward/record.url?eid=2-s2.0-57449102928&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2008.09.028
  19. Song, R.; Duarte, T.L.; Almeida, G.M.; Farmer, P.B.; Cooke, M.S.; Zhang, W.; Sheng, G.; Fu, J.; Jones, G.D.D.. "Cytotoxicity and gene expression profiling of two hydroxylated polybrominated diphenyl ethers in human H295R adrenocortical carcinoma cells". Toxicology Letters 185 1 (2009): 23-31. http://www.scopus.com/inward/record.url?eid=2-s2.0-58349122277&partnerID=MN8TOARS.
    10.1016/j.toxlet.2008.11.011
  20. Corti, A.; Duarte, T.L.; Giommarelli, C.; De Tata, V.; Paolicchi, A.; Jones, G.D.D.; Pompella, A.. "Membrane gamma-glutamyl transferase activity promotes iron-dependent oxidative DNA damage in melanoma cells". Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 669 1-2 (2009): 112-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349152500&partnerID=MN8TOARS.
    10.1016/j.mrfmmm.2009.05.010
  21. Almeida, G.M.; Duarte, T.L.; Farmer, P.B.; Steward, W.P.; Jones, G.D.D.. "Multiple end-point analysis reveals cisplatin damage tolerance to be a chemoresistance mechanism in a NSCLC model: Implications for predictive testing". International Journal of Cancer 122 8 (2008): 1810-1819. http://www.scopus.com/inward/record.url?eid=2-s2.0-40349089783&partnerID=MN8TOARS.
    10.1002/ijc.23188
  22. Cooke, M.S.; Duarte, T.L.; Cooper, D.; Chen, J.; Nandagopal, S.; Evans, M.D.. "Combination of azathioprine and UVA irradiation is a major source of cellular 8-oxo-7,8-dihydro-2'-deoxyguanosine". DNA Repair 7 12 (2008): 1982-1989. http://www.scopus.com/inward/record.url?eid=2-s2.0-55149124391&partnerID=MN8TOARS.
    10.1016/j.dnarep.2008.08.007
  23. Corti, A.; Duarte, T. L.; Paolicchi, A.; Dominici, S.; Jones, G. D. D.; Dilda, P.; Hogg, P. J.; Pompella, A.. "GAMMA-GLUTAMYLTRANSFERASE OF CANCER CELLS AT THE CROSSROADS OF REDOX REGULATION, TUMOR PROGRESSION, DRUG RESISTANCE AND DRUG TARGETING". Anticancer Research 28 5C (2008): 3451-3452. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000260555300544&KeyUID=WOS:000260555300544.
  24. Duarte, Tiago L.; Cooke, Marcus S.; Jones, George D. D.. "Vitamin C Promotes Dermal Fibroblast Proliferation, Migration and Replication-Associated Base Excision Repair of Oxidised DNA Bases: a New Protective Role for Vitamin C in the Skin?". Free Radical Biology and Medicine 45 (2008): S121-S121. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000260867900343&KeyUID=WOS:000260867900343.
  25. Barnes, T.A.; McDonald, J.; Rowbotham, D.J.; Duarte, T.L.; Lambert, D.G.. "Effects of receptor density on Nociceptin/OrphaninFQ peptide receptor desensitisation: Studies using the ecdysone inducible expression system". Naunyn-Schmiedeberg's Archives of Pharmacology 376 3 (2007): 217-225. http://www.scopus.com/inward/record.url?eid=2-s2.0-35648995946&partnerID=MN8TOARS.
    10.1007/s00210-007-0189-z
  26. Crespo-López, M.E.; Pala, I.; Duarte, T.L.; Dowling, T.E.; Coelho, M.M.. "Genetic structure of the diploid-polyploid fish Squalius alburnoides in southern Iberian basins Tejo and Guadiana, based on microsatellites". Journal of Fish Biology 71 SUPPL. C (2007): 423-436. http://www.scopus.com/inward/record.url?eid=2-s2.0-36549074185&partnerID=MN8TOARS.
    10.1111/j.1095-8649.2007.01688.x
  27. Duarte, T.L.; Almeida, G.M.; Jones, G.D.D.. "Investigation of the role of extracellular H2O2 and transition metal ions in the genotoxic action of ascorbic acid in cell culture models". Toxicology Letters 170 1 (2007): 57-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947628181&partnerID=MN8TOARS.
    10.1016/j.toxlet.2007.02.005
  28. Duarte, T.L.; Jones, G.D.D.. "Vitamin C modulation of H2O2-induced damage and iron homeostasis in human cells". Free Radical Biology and Medicine 43 8 (2007): 1165-1175. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548489878&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2007.07.017
  29. Almeida, G.M.; Duarte, T.L.; Steward, W.P.; Jones, G.D.D.. "Detection of oxaliplatin-induced DNA crosslinks in vitro and in cancer patients using the alkaline comet assay". DNA Repair 5 2 (2006): 219-225. http://www.scopus.com/inward/record.url?eid=2-s2.0-30344435005&partnerID=MN8TOARS.
    10.1016/j.dnarep.2005.09.010
  30. Crespo-López, M.E.; Duarte, T.; Dowling, T.; Coelho, M.M.. "Modes of reproduction of the hybridogenetic fish Squalius alburnoides in the Tejo and Guadiana rivers: An approach with microsatellites". Zoology 109 4 (2006): 277-286. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749985440&partnerID=MN8TOARS.
    10.1016/j.zool.2006.03.008
  31. Cooke, M.S.; Singh, R.; Hall, G.K.; Mistry, V.; Duarte, T.L.; Farmer, P.B.; Evans, M.D.. "Evaluation of enzyme-linked immunosorbent assay and liquid chromatography-tandem mass spectrometry methodology for the analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine in saliva and urine". Free Radical Biology and Medicine 41 12 (2006): 1829-1836. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751560663&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2006.09.009
  32. Almeida, Gabriela M.; Duarte, Tiago L.; Farmer, Peter B.; Steward, William P.; Jones, George D. D.. "Multiple end-point analysis reveals cisplatin damage tolerance to be a chemoresistant mechanism in a NSCLC model". Mutagenesis 21 4 (2006): 286-287. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000240833700048&KeyUID=WOS:000240833700048.
  33. Duarte, T.L.; Lunec, J.. "Review: When is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C". Free Radical Research 39 7 (2005): 671-686. http://www.scopus.com/inward/record.url?eid=2-s2.0-21844465931&partnerID=MN8TOARS.
    10.1080/10715760500104025
Livro
  1. Duarte, T. L.; Almeida, I. F.. Vitamin C, gene expression and skin health. Wageningen Academic Publishers. 2012.
    10.3920/978-90-8686-729-5_7
Poster em conferência
  1. Ânia Gomes; Magalhães, Nisa; Beatriz Silva; Maria J. Salazar; Almeida, Henrique; Duarte, Tiago L; Silva, Elisabete; Gouveia, Alexandra; Adriana Raquel Rodrigues. "Iron overload in mice subcutaneous adipose tissue downregulates lipid metabolism and adipocyte browning". Trabalho apresentado em Yes meeting 2023, 2023.
  2. Beatriz Silva; Ânia Gomes; Magalhães, Nisa; Maria J. Salazar; Almeida, Henrique; Duarte, Tiago L; Matos, Liliana; et al. "The subcutaneous adipose tissue from HFE-knockout mice accumulates high levels of iron and develops a pro-inflammatory phenotype.". Trabalho apresentado em IJUP 2023, 2023.
  3. Ânia Gomes; Magalhães, Nisa; Beatriz Silva; Maria J. Salazar; Almeida, Henrique; Duarte, Tiago L; Silva, Elisabete; Gouveia, Alexandra; Adriana Raquel Rodrigues. "Lipid metabolism in iron overloaded mice adipose tissue". Trabalho apresentado em IJUP 2023, 2023.
Pré-impressão
  1. Arede, Liliana; Coutinho, Rita; Duarte, Tiago L; Lopes, Marta; Simões, Rui V; Silva, Susana; Baptista, Pedro; et al. "Recapitulation of clinical features in a patient-derived xenograft mouse model of VEXAS Syndrome". 2024. http://dx.doi.org/10.1101/2024.08.27.609907.
    10.1101/2024.08.27.609907
  2. Wideman, Sarah K.; Frost, Joe N.; Richter, Felix C.; Naylor, Caitlin; Lopes, José M.; Viveiros, Nicole; Teh, Megan R.; et al. "Cellular iron governs the host response to malaria". 2023. http://dx.doi.org/10.1101/2023.02.05.527208.
    10.1101/2023.02.05.527208
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/04/25 The role of the heme-exporter FLVCR1 in hepatocellular carcinoma European Iron Club Meeting 2024
INSERM (Toulouse, França)
2023/10/24 Iron overload induces dysplastic erythropoiesis and features of myelodysplasia in Nrf2-deficient mice 1st Symposium on Iron Metabolism and Cancer
i3S (Porto, Portugal)
2019/11/15 Nrf2 and hepcidin double knockout: a new pre-clinical mouse model of MDS? Meeting of the Portuguese Society of Hematology
Portuguese Society of Hematology (Braga, Portugal)
2018/02/10 SNP in the NRF2 promoter associates with increased total body iron in a well-characterized cohort of HFE-linked haemochromatosis patients European Iron Club 2018
European Iron Club Society (Zurich, Suiça)
2017/06/26 NRF2 modulates the hemochromatotic phenotype of Hfe-null mice European Iron Club 2017
European Iron Club Society (Munster, Alemanha)
2014/09/13 The genetic suppression of NRF2 causes age-related hepatic fibrosis in a mouse model of hereditary hemochromatosis (HFE knock-out) European Iron Club 2014 Meeting
European Iron Club Society (Verona, Itália)
2013/12/12 The genetic suppression of Nrf2 promotes hepatic fibrosis in a mouse model of hereditary hemotchromatosis (Hfe knock-out) 5th Symposium in Metabolism
Faculty of Medicine - University of Porto (Porto, Portugal)
2013/06/04 Transcription factor Nrf2 Protects Against Dietary Iron-Induced Liver Injury: Is Nrf2 A Potential Genetic Modifier Of Iron Overload-Associated Liver Disease? XXXVIII Jornadas Portuguesas de Genética
Portuguese Society of Genetics (Porto, Portugal)
2013/04/18 Nrf2 protects against dietary iron-induced liver injury 2013 International BioIron Society (IBIS) Annual Meeting
International BioIron Society (IBIS) (London, Reino Unido)
2012/11/23 Understanding the protective role of the antioxidant/cytoprotective response coordinated by transcription factor Nrf2 against iron toxicity in the context of iron overload disease Fourth Symposium on Bioengineering
Universidade do Porto (Porto, Portugal)
2012/09/09 Understanding the role of Nrf2 signalling in the cellular defence against iron toxicity: Nrf2 protects against dietary iron-induced liver injury 16th Biennial Meeting of the Society for Free Radical Research - International
Society for Free Radical Research - International (London, Reino Unido)
2012/05/11 Nrf2 protects mice against dietary iron-induced liver injury Third Scientific Retreat of the Institute for Health Research and Innovation (i3S)
Institute for Health Research and Innovation (i3S) (Póvoa de Varzim, Portugal)
2011/05/26 Understanding the role of Nrf2/ARE signaling in the cellular defence against iron toxicity 2011 International BioIron Society (IBIS) Annual Meeting
International BioIron Society (IBIS) (Vancouver, Canadá)
2009/09/17 Effects of vitamin C on DNA damage and repair in human fibroblasts: lessons from the comet assay Comet Assay Workshop: DNA damage and repair
Universidade de Trás-os-Montes e Alto Douro (Vila Real, Portugal)
2002/09/28 Microarray analysis of in vitro vitamin C induced gene expression of human fibroblasts European Research on Functional Effects of Dietary Antioxidants: Benefits and Risks
European Research on Functional Effects of Dietary Antioxidants (EUROFEDA) (Cambridge, Reino Unido)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023/09 - 2024/11/28 The Role of the Heme-Exporter FLVCR1 in Hepatocellular Carcinoma
Orientador de Catarina Neves Godinho
 Molecular Medicine and Oncology (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2022/01 - 2022/06/23 The impact of FLVCR1 loss in human hepatoma cell lines
Orientador
 Biologia Celular e Molecular (Licenciatura/Bacharelato)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019 - 2021 The impact of ionizing radiation on macrophage iron metabolism and on macrophage-mediated cancer cell invasion, migration and angiogenesis
Coorientador
 Oncobiologia (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017/10 - 2018/11/27 Pathogenesis of arthropathy in Hereditary Hemochromatosis: the synoviocyte-macrophage interplay
Coorientador
 Bioquímica (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2017 - 2018/11/16 The impact of iron overload on biliary excretion
Orientador
 Bioquímica (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2017 - 2018/07/10 The impact of Ccl2 knock-out on iron metabolism and erythropoiesis
Coorientador
 Bioquímica (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Ciências, Portugal
2014/09 - 2015/12/03 Searching for a mouse model of non-alcoholic steatohepatitis (NASH): the contribution of liver iron, aging and Nrf2
Orientador
 Biologia Celular e Molecular (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2014/09 - 2015/12/03 The protective role of transcription factor NRF2 against liver injury in human and mouse models of Hereditary Hemochromatosis
Orientador
 Biologia Celular e Molecular (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2012 - 2013/11/20 Does the Nrf2 signalling pathway play a significant protective role against oxidative tissue damage in a mouse model of spontaneous iron overload (HFE knock-out)?
Orientador
 Medicina e Oncologia Molecular (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2011 - 2012/12/17 Investigation of the protective role of the Nrf2 signalling pathway in an experimental model of iron overload in vivo
Orientador
 Tecnologia Bioquímica em Saúde (Mestrado)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2011 - 2012/07/20 Is the cytoprotective Nrf2 signalling pathway induced in human blood monocytes from HFE hemochromatosis patients and is there an association with disease penetrance?
Orientador
 Bioquímica (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2009 - 2010 Analysis of oxidative DNA damage in hereditary hemochromatosis patients
Orientador
 Biologia (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Ciências, Portugal
2009 - 2010 Does the expression of C282Y HFE in vitro activate cytoprotective Nrf2/ARE signaling via an UPR?
Orientador
 Bioquímica (Licenciatura/Bacharelato)
Universidade do Porto Faculdade de Ciências, Portugal
2007 - 2008 Is oxidative damage to DNA a side effect of therapeutic thiopurines? Application of the comet assay to the study of the immunosuppressive drug azathioprine (6-thioguanine), and its formation of oxidative damage to DNA upon exposure to UVA
Coorientador
 Molecular Genetics (Mestrado)
University of Leicester Department of Genetics, Reino Unido
2007 - 2008 Formation and repair of UVA-induced cyclobutane thymine dimers
Coorientador
 Molecular Pathology and Toxicology (Mestrado)
University of Leicester Department of Cancer Studies and Molecular Medicine, Reino Unido
2007 - 2007 Formation of oxidatively damaged DNA by azathioprine
Coorientador
University of Leicester Department of Cancer Studies and Molecular Medicine, Reino Unido
2007 - 2007 Detection of oxidative damage to DNA in specific gene sequences
Coorientador
 Molecular Genetics (Mestrado)
University of Leicester Department of Genetics, Reino Unido

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2024/11/28 The Role of the Heme-Exporter FLVCR1 in Hepatocellular Carcinoma
Orientador
 Catarina Neves Godinho (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2019/11/05 Female fertility decline: exploring the role of antioxidants in delaying ovarian ageing
Arguente principal
 Filipa Timóteo Ferreira (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2018/11/16 The impact of iron overload on biliary excretion
Orientador
 Catarina Domingues Vasco (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2017/11/20 Uncovering the mechanism of Ferroportin-1 downmodulation upon Leishmania infantum infection
Arguente principal
 Maria Silva Vieira (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2017/05/24 Contribution to the molecular characterization of osteoarthritis and osteoporosis phenotypes associated with Hereditary Hemochromatosis
Arguente principal
 Márcio Alexandre Filipe Simão (Doutoramento)
Universidade do Algarve, Portugal
2016/11/17 Implementation and validation of in vitro methodologies for phototoxicity evaluation of raw materials of pharmaceutical and cosmetic products
Arguente principal
 Bruna Catarina de Freitas Maciel (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
2015/12/03 Searching for a mouse model of non-alcoholic steatohepatitis (NASH): the contribution of liver iron, aging and Nrf2
Orientador
 Sílvia Maria de Sousa Chambel (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2015/12/03 The protective role of transcription factor NRF2 against liver injury in human and mouse models of Hereditary Hemochromatosis
Orientador
 Andreia dos Santos Gonçalves (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
2015/07/16 Regulation of iron metabolism in different bacterial infections
Arguente principal
 Patrícia Daniela Oliveira Ferreira (Mestrado)
Universidade de Aveiro, Portugal
2015/07/01 The effect of iron oxide nanoparticles on T lymphocytes
Arguente principal
 Daniel Azevedo Mendes (Mestrado)
Universidade do Porto, Portugal
2013/11/20 Does the Nrf2 signalling pathway play a significant protective role against oxidative tissue damage in a mouse model of spontaneous iron overload (HFE knock-out)?
Orientador
 Carolina Pontes Geraz Caldas (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2012/12/20 Hereditary hemochromatosis: cellular response to oxidative stress
Arguente principal
 Lara Filipa Rocha Andrade (Mestrado)
Universidade de Aveiro, Portugal
2012/12/17 Investigation of the protective role of the Nrf2 signalling pathway in an experimental model of iron overload in vivo
Orientador
 Ana Luísa Gomes Santos (Mestrado)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2012/07/20 Is the cytoprotective Nrf2 signalling pathway induced in human blood monocytes from HFE hemochromatosis patients and is there an association with disease penetrance?
Orientador
 Filipe de Sousa (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2020/11 - Atual Antioxidants & Redox Signaling (1523-0864) Mary Ann Liebert, Inc.

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2021 - 2021 Grant proposal reviewer (Generic call, panel “CE14 - Physiologie et physiopathologie”) Agence nationale de la recherche
2019 - 2019 Grant proposal reviewer
Avaliador
 Narodowe Centrum Nauki

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2021/05 - Atual Lectured on 'The contribution of oxidative stress, iron overload and lipid accumulation to chronic liver disease' in the 'Redox state: diet, metabolic regulation and ageing' module of the MSc in Metabolism ' Biopathology and Experimentation (MMBE) of the Faculty of Medicine, University of Porto. (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2014 - 2018 Lecturer in the ‘Oxidative stress and antioxidants’ module of the Doctoral Programme in Metabolism–Clinical and Experimental at Faculty of Medicine, University of Porto Metabolismo - Clínica e Experimentação (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2010 - 2018 Lecturer in the ‘Iron biology’ module of the Graduate Program in Areas of Basic and Applied Biology (GABBA) Program, an official PhD Program of the University of Porto Biologia Básica e Aplicada (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - 2017 Lecturer in the 'BIOTA: BIOTechnology tools for food, environmental and health Applications' module of the Doctoral Programme in Biotechnology at Centro de Biotecnologia e Química Fina, Catholic University Biotecnologia (Curso de doutoramento (conclusão de unidades curriculares)) Portuguesa Centro de Biotecnologia e Química Fina, Portugal

Entrevista / Programa (rádio / tv)

Programa Tema
2019/06/11 - 2019/06/11 Mentes que Brilham

Membro de associação

Nome da associação Tipo de participação
2017 - Atual European Iron Club Society Member
2011 - 2018 International BioIron Society Member
2008 - 2012 Society for Free Radical Biology and Medicine Member
2005 - 2008 Society for Free Radical Research - Europe Member
2005 - 2007 Biochemical Society Member

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2023 - Atual Guest Associate Editor of Frontiers in Physiology (Red Blood Cell Physiology)
2019/01/01 - Atual Animal Welfare and Ethics Review Body
Membro
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Distinções

Outra distinção

2006 PhD Research Prize
University of Leicester Department of Cancer Studies and Molecular Medicine, Reino Unido