???global.info.a_carregar???
Identificação

Identificação pessoal

Nome completo
Francisco Javier Otero Espinar

Nomes de citação

  • Espinar, Francisco
  • Otero-Espinar Francisco
  • Otero espINar Francisco J.

Identificadores de autor

Ciência ID
7511-1D58-A878
ORCID iD
0000-0001-9030-2253

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Espanhol; Castelhano Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Galego (Idioma materno)
Francês Utilizador proficiente (C1) Utilizador proficiente (C2) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Inglês Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2)
Formação
Grau Classificação
2001
Concluído
 Especialista en Farmacia Industrial e Galenica (Doctor)
Especialização em Farmacia e Tecnología Farmaceutica
Universidade de Santiago de Compostela, Espanha
2001
Concluído
 Especialista en Análisis e Control en Medicamentos e Drogas (Doctor)
Universidade de Santiago de Compostela - Campus Vida, Espanha
1982 - 1987
Concluído
 Licenciado en Farmacia (Doctor)
Universidade de Santiago de Compostela - Campus Vida, Espanha
"Complejos de inclusión con ciclodextrinas como sistemas para mejorar las características biofarmacéuticas del naproxen" (TESE/DISSERTAÇÃO)
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2019 - 2033 Professor Catedrático (Docente Universitário) Universidade de Santiago de Compostela - Campus Vida, Espanha
Universidade de Santiago de Compostela - Campus Vida, Espanha
1995 - 2019 Professor Associado (Docente Universitário) Universidade de Santiago de Compostela - Campus Vida, Espanha
1990 - 1995 Professor Auxiliar (Docente Universitário) Universidade de Santiago de Compostela - Campus Vida, Espanha
Produções

Publicações

Artigo em conferência
  1. A Fernández-Ferreiro; M González-Barcia; L Garcia-Quintanilla; A Luaces; V Díaz-Tome; R Touriño-Peralba; I Alonso-Rodriguez; et al. "PP-015 Tacrolimus eye drops as a therapeutic alternative for paediatric patients with inflammatory ocular surface diseases". 2017.
    10.1136/ejhpharm-2017-000640.462
  2. A Fernández-Ferreiro; M González-Barcia; L Garcia-Quintanilla; A Luaces; V Díaz-Tome; I Alonso-Rodriguez; X Garcia-Otero; M Lamas; FJ Otero-Espinar. "PP-016 Effect of tacrolimus eye drops on human primary corneal epithelial cells". 2017.
    10.1136/ejhpharm-2017-000640.463
Artigo em revista
  1. Eider Arana; Ana Gonzalo; Noelia Andollo; Miguel Pérez-Garrastachu; Francisco Otero-Espinar; Victoria Díaz-Tomé; Felipe Goñi-de-Cerio; et al. "The new bilastine eye drop formulation protects against conjunctival dehydration and promotes corneal wound healing in a comparative in vitro study". Scientific Reports (2025): http://dx.doi.org/10.1038/s41598-025-91743-0.
    10.1038/s41598-025-91743-0
  2. Eines Monteagudo-Vilavedra; Daniel Rodrigues; Giorgia Vella; Susana B. Bravo; Carmen Pena; Laura Lopez-Valverde; Cristobal Colon; et al. "Novel Phenotypical and Biochemical Findings in Mucolipidosis Type II". International Journal of Molecular Sciences (2025): https://doi.org/10.3390/ijms26062408.
    10.3390/ijms26062408
  3. Brandon Aguiar; Ana Rita Alfenim; Cláudia Sofia Machado; Joana Moreira; Miguel Pinto; Francisco J. Otero-Espinar; Fernanda Borges; Carlos Fernandes. "Exploring Nano-Delivery Systems to Enhance the Edaravone Performance in Amyotrophic Lateral Sclerosis Treatment". International Journal of Molecular Sciences (2025): https://doi.org/10.3390/ijms26052146.
    10.3390/ijms26052146
  4. Xurxo García-Otero; Rubén Varela-Fernández; Andrea Cuartero-Martínez; Noemí Gómez-Lado; Miguel González-Barcia; Cristina Mondelo-García; Carolina Feitosa; et al. "Intravitreal Administration of Adalimumab-Loaded Poly(Lactic-co-Glycolic Acid) Nanoparticles: Effects on Biodistribution and Pharmacokinetics". Small Science (2025): https://doi.org/10.1002/smsc.202400494.
    10.1002/smsc.202400494
  5. Jessica Codesido; Lara García-Varela; Xurxo García-Otero; Sheila Bouzón-Barreiro; Noemí Gómez-Lado; Francisco José Toja-Camba; Cristina Mondelo-García; et al. "PET biodistribution study of subcutaneous and intravenous administration of adalimumab in an inflammatory bowel disease model". International Journal of Pharmaceutics (2025): http://dx.doi.org/10.1016/j.ijpharm.2024.125011.
    10.1016/j.ijpharm.2024.125011
  6. Cláudia Sofia Machado; Miguel Pinto; Brandon Aguiar; Sofia Costa; Bruno Sarmento; Francisco J. Otero Espinar; Fernanda Borges; Carlos Fernandes. "Exploring Nanocarriers for Boosting Entacapone Bioavailability: A Journey through System Characterization and Assessment of Toxicity and Pharmacological and 2D Permeability Paybacks". ACS Applied Materials & Interfaces (2024): https://doi.org/10.1021/acsami.4c12372.
    10.1021/acsami.4c12372
  7. María Puente Iglesias; Andrea Cuartero Martí­nez; ROSARIO TOURIÑO-PERALBA; María Teresa Rodríguez-Ares; Maria J Giraldez; Eva Yebra-Pimentel; Laura García-Quintanilla; et al. "Clinical Effectiveness, Safety, and Compliance of Two Compounded Formulations of Tacrolimus Eye Drops: An Open-Label, Sequential Prospective Study". International Journal of Molecular Sciences (2024): https://www.mdpi.com/1422-0067/25/18/9847.
    10.3390/ijms25189847
  8. Andrea Cuartero Martí­nez; Xurxo García-Otero; Jessica Codesido; Noemí Gómez-Lado; Jesús Mateos; Susana B. Bravo; Carmen Antía Rodríguez-Fernández; et al. "Preclinical characterization of endotoxin-induced uveitis models using OCT, PET/CT and proteomics". International Journal of Pharmaceutics (2024): http://dx.doi.org/10.1016/j.ijpharm.2024.124516.
    10.1016/j.ijpharm.2024.124516
  9. Iria Seoane-Viaño; Mariola Seoane-Gigirey; Carlos Bendicho-Lavilla; Luz M. Gigirey; Francisco J. Otero-Espinar; Santiago Seoane-Trigo. "The Integration of Advanced Drug Delivery Systems into Conventional Adjuvant Therapies for Peri-Implantitis Treatment". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16060769.
    10.3390/pharmaceutics16060769
  10. Miguel Pinto; Cláudia Sofia Machado; Sandra Barreiro; Francisco J. Otero-Espinar; Fernando Remião; Fernanda Borges; Carlos Fernandes. "Rescuing a Troubled Tolcapone with PEGylated PLGA Nanoparticles: Design, Characterization, and Hepatotoxicity Evaluation". ACS Applied Materials & Interfaces (2024): https://doi.org/10.1021/acsami.4c00614.
    10.1021/acsami.4c00614
  11. J. Victor. Álvarez; Susana B. Bravo; María Pilar Chantada-Vázquez; Carmen Pena; Cristóbal Colón; Shunji Tomatsu; Francisco J. Otero-Espinar; María L. Couce. "Morquio A Syndrome: Identification of Differential Patterns of Molecular Pathway Interactions in Bone Lesions". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25063232.
    10.3390/ijms25063232
  12. Laura García-Quintanilla; Pablo Almuiña-Varela; María José Rodríguez-Cid; María Gil-Martínez; Maximino J. Abraldes; Francisco Gómez-Ulla; Miguel González-Barcia; et al. "The Effect of Systemic Parameters and Baseline Characteristics in Short-Term Response Analysis with Intravitreal Ranibizumab in Treatment-Naive Patients with Neovascular Age-Related Macular Degeneration". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16010105.
    10.3390/pharmaceutics16010105
  13. Carlos Bendicho-Lavilla; Victoria Díaz-Tomé; Iria Seoane-Viaño; Asteria M. Luzardo-Álvarez; Francisco J. Otero-Espinar. "Development of inert coatings to prevent drug retention in 3D-printed diffusion cells". International Journal of Pharmaceutics (2024): 124256-124256. https://www.sciencedirect.com/science/article/pii/S0378517324004903.
    https://doi.org/10.1016/j.ijpharm.2024.124256
  14. Ana Castro Balado; Andrea Cuartero-Martínez; Hugo Pena-Verdeal; Gonzalo Hermelo-Vidal; Anja Schmidt; Belén Montero; Manuela Hernández-Blanco; et al. "Cysteamine Eye Drops in Hyaluronic Acid Packaged in Innovative Single-Dose Systems, Part II: Long-Term Stability and Clinical Ocular Biopermanence". Pharmaceutics 15 11 (2023): 2589-2589. http://dx.doi.org/10.3390/pharmaceutics15112589.
    10.3390/pharmaceutics15112589
  15. Manuel Gago-Guillán; Xurxo García-Otero; Soledad Anguiano-Igea; Francisco J. Otero-Espinar. "Compression pressure-induced synergy in xanthan and locust bean gum hydrogels. Effect in drug delivery". Journal of Drug Delivery Science and Technology (2023): https://doi.org/10.1016/j.jddst.2023.105025.
    10.1016/j.jddst.2023.105025
  16. Uxía Regueiro; Maite López-López; Rubén Varela-Fernández; Francisco Javier Otero-Espinar; Isabel Lema. "Biomedical Applications of Lactoferrin on the Ocular Surface". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15030865.
    10.3390/pharmaceutics15030865
  17. Eloy Pena-Rodríguez; Teresa García-Berrocoso; Ezequiel Vázquez Fernández; Francisco J. Otero-Espinar; Joaquin Abian; Francisco Fernández-Campos. "Monitoring dexamethasone skin biodistribution with ex vivo MALDI-TOF mass spectrometry imaging and confocal Raman microscopy". International Journal of Pharmaceutics (2023): 122808-122808. http://dx.doi.org/10.1016/j.ijpharm.2023.122808.
    10.1016/j.ijpharm.2023.122808
  18. Guillermo Blanco-Fernandez; Barbara Blanco-Fernandez; Anxo Fernández-Ferreiro; Francisco J. Otero-Espinar. "Lipidic lyotropic liquid crystals: Insights on biomedical applications". Advances in Colloid and Interface Science (2023): 102867-102867. http://dx.doi.org/10.1016/j.cis.2023.102867.
    10.1016/j.cis.2023.102867
  19. Iria Varela-Rey; Daniel de la Iglesia; Alba San Bruno-Ruz; Rafael Mejuto-Fernández; Luz Monteserín-Ron; Javier López-Diaz; Pedro García-Salom; et al. "Design and biopharmaceutical preclinical characterisation of a new thermosensitive hydrogel for the removal of gastric polyps". International Journal of Pharmaceutics (2023): 122706-122706. http://dx.doi.org/10.1016/j.ijpharm.2023.122706.
    10.1016/j.ijpharm.2023.122706
  20. Castro-Balado, Ana; Novo-Veleiro, Ignacio; Vázquez-Agra, Néstor; Barbeito-Castiñeiras, Gema; Estany-Gestal, Ana; Trastoy-Pena, Rocío; González-Barcia, Miguel; et al. "Efficacy and Safety of Inhaled Ethanol in Early-Stage SARS-CoV-2 Infection in Older Adults: A Phase II Randomized Clinical Trial". Pharmaceutics (2023): https://www.mdpi.com/1999-4923/15/2/667.
    10.3390/pharmaceutics15020667
  21. Zalacain-Vicuña, A.J.; Nieto, C.; Picas, J.; Martínez, H.; Bermejo, R.; Corrales, A.; Campos, F.F.; et al. "Efficacy and safety of a new medicated nail hydrolacquer in the treatment of adults with toenail onychomycosis: A randomised clinical trial". Mycoses 66 7 (2023): 566-575. http://www.scopus.com/inward/record.url?eid=2-s2.0-85142293374&partnerID=MN8TOARS.
    10.1111/myc.13543
  22. Bendicho-Lavilla, C.; Seoane-Viaño, I.; Santos-Rosales, V.; Díaz-Tomé, V.; Carracedo-Pérez, M.; Luzardo-Álvarez, A.M.; García-González, C.A.; Otero-Espinar, F.J.. "Intravitreal implants manufactured by supercritical foaming for treating retinal diseases". Journal of Controlled Release 362 (2023): 342-355. http://www.scopus.com/inward/record.url?eid=2-s2.0-85169801626&partnerID=MN8TOARS.
    10.1016/j.jconrel.2023.08.047
  23. Victoria Díaz Tomé; Carlos Bendicho-Lavilla; Xurxo García-Otero; Rubén Varela-Fernández; Manuel Martin-Pastor; José Llovo-Taboada; Pilar Alonso-Alonso; et al. "Antifungal Combination Eye Drops for Fungal Keratitis Treatment". Pharmaceutics 15 1 (2022): 35-35. http://dx.doi.org/10.3390/pharmaceutics15010035.
    10.3390/pharmaceutics15010035
  24. Ana Castro Balado; Enrique Bandín-Vilar; Andrea Cuartero-Martínez; Laura García-Quintanilla; Gonzalo Hermelo-Vidal; Xurxo García-Otero; Lorena Rodríguez-Martínez; et al. "Cysteamine Eye Drops in Hyaluronic Acid Packaged in Innovative Single-Dose Systems: Stability and Ocular Biopermanence". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/10/2194.
    10.3390/pharmaceutics14102194
  25. Cristina Moles-Aranda; Noelia Pérez-González; Ana C. Calpena-Campmany; María J. Martín-Villena; Francisco J. Otero-Espinar; Patricia Severino; Eliana B. Souto; José A. Morales-Molina; Beatriz Clares-Naveros. "Preparation and ex vivo investigation of an injectable microparticulate formulation for gastrointestinal mucosa polyp resection". European Journal of Pharmaceutics and Biopharmaceutics (2022): https://doi.org/10.1016/j.ejpb.2022.07.012.
    10.1016/j.ejpb.2022.07.012
  26. "Mucoadhesive PLGA Nanospheres and Nanocapsules for Lactoferrin Controlled Ocular Delivery". Pharmaceutics (2022): http://dx.doi.org/10.3390/pharmaceutics14040799.
    10.3390/pharmaceutics14040799
  27. "Bringing lipidic lyotropic liquid crystal technology into biomedicine". Trends in Pharmacological Sciences (2022): http://dx.doi.org/10.1016/j.tips.2022.03.004.
    10.1016/j.tips.2022.03.004
  28. Carlos Bendicho-Lavilla; Iria Seoane-Viaño; Francisco J. Otero-Espinar; Asteria Luzardo-Álvarez. "Fighting type 2 diabetes: Formulation strategies for peptide-based therapeutics". Acta Pharmaceutica Sinica B (2022): https://doi.org/10.1016/j.apsb.2021.08.003.
    10.1016/j.apsb.2021.08.003
  29. García-Otero, X.; Mondelo-García, C.; Bandín-Vilar, E.; Gómez-Lado, N.; Silva-Rodríguez, J.; Rey-Bretal, D.; Victoria Otero-Espinar, M.; et al. "PET study of intravitreal adalimumab pharmacokinetics in a uveitis rat model". International Journal of Pharmaceutics 627 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85139733758&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2022.122261
  30. Cuartero-Martínez, A.; Hermelo-Vidal, G.; Castro-Balado, A.; Gómez-García, Á.; González-Barcia, M.; Otero-Espinar, F.J.; Fernández-Ferreiro, A.; Mondelo-García, C.. "Stability of insulin eye drops in the treatment of refractory corneal ulcers,Estabilidad del colirio de insulina para el tratamiento de úlceras corneales refractarias". Farmacia Hospitalaria 46 6 (2022): 335-339. http://www.scopus.com/inward/record.url?eid=2-s2.0-85143983610&partnerID=MN8TOARS.
    10.7399/fh.13293
  31. Varela-Fernández, R.; García-Otero, X.; Díaz-Tomé, V.; Regueiro, U.; López-López, M.; González-Barcia, M.; Isabel Lema, M.; Javier Otero-Espinar, F.. "Lactoferrin-loaded nanostructured lipid carriers (NLCs) as a new formulation for optimized ocular drug delivery". European Journal of Pharmaceutics and Biopharmaceutics 172 (2022): 144-156. http://www.scopus.com/inward/record.url?eid=2-s2.0-85124982664&partnerID=MN8TOARS.
    10.1016/j.ejpb.2022.02.010
  32. González-Barcia, M.; Mondelo-García, C.; Otero-Espinar, F.J.; Fernández-Ferreiro, A.. "Selected evidence and cherry picking pharmaceutical compounding,Evidencia seleccionada y cherry picking en formulación magistral". Farmacia Hospitalaria 46 2 (2022): 100-101. http://www.scopus.com/inward/record.url?eid=2-s2.0-85127498943&partnerID=MN8TOARS.
    10.7399/fh.13230
  33. Varela-Fernández, R.; Bendicho-Lavilla, C.; Martin-Pastor, M.; Herrero Vanrell, R.; Lema-Gesto, M.I.; González-Barcia, M.; Otero-Espinar, F.J.. "Design, optimization, and in vitro characterization of idebenone-loaded PLGA microspheres for LHON treatment". International Journal of Pharmaceutics 616 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85123882843&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2022.121504
  34. Xurxo García-Otero; Cristina Mondelo-García; Francisco González; Roman Perez-Fernandez; Leandro Avila; Jose Ramón Antúnez-López; Miguel González-Barcia; et al. "Anti-Inflammatory Effect of Tacrolimus/Hydroxypropyl-ß-Cyclodextrin Eye Drops in an Endotoxin-Induced Uveitis Model". Pharmaceutics 13 10 (2021): 1737-1737. https://doi.org/10.3390/pharmaceutics13101737.
    10.3390/pharmaceutics13101737
  35. Elías Quezada; Fernanda Rodríguez-Enríquez; Reyes Laguna; Elena Cutrín; Francisco Otero; Eugenio Uriarte; Dolores Viña. "Curcumin–Coumarin Hybrid Analogues as Multitarget Agents in Neurodegenerative Disorders". Molecules (2021): https://doi.org/10.3390/molecules26154550.
    10.3390/molecules26154550
  36. José V. Álvarez; Susana B. Bravo; María Pilar Chantada-Vázquez; Sofía Barbosa-Gouveia; Cristóbal Colón; Olalla López-Suarez; Shunji Tomatsu; Francisco J. Otero-Espinar; María L. Couce. "Plasma Proteomic Analysis in Morquio A Disease". International Journal of Molecular Sciences 22 11 (2021): 6165-6165. https://doi.org/10.3390/ijms22116165.
    10.3390/ijms22116165
  37. Victoria Díaz-Tomé; Xurxo García-Otero; Rubén Varela-Fernández; Manuel Martín-Pastor; Andrea Conde-Penedo; Pablo Aguiar; Miguel González-Barcia; Anxo Fernández-Ferreiro; Francisco J Otero-Espinar. "In situ forming and mucoadhesive ophthalmic voriconazole/HPßCD hydrogels for the treatment of fungal keratitis". International Journal of Pharmaceutics (2021):
    10.1016/j.ijpharm.2021.120318
  38. Ana Castro Balado; Cristina Mondelo-García; Letricia Barbosa-Pereira; Iria Varela-Rey; Ignacio Novo-Veleiro; Néstor Vázquez-Agra; José Ramón Antúnez-López; et al. "Development and Characterization of Inhaled Ethanol as a Novel Pharmacological Strategy Currently Evaluated in a Phase II Clinical Trial for Early-Stage SARS-CoV-2 Infection". Pharmaceutics (2021): https://www.mdpi.com/1999-4923/13/3/342.
    10.3390/pharmaceutics13030342
  39. Rubén Varela-Fernández; Xurxo García-Otero; Victoria Díaz-Tomé; Uxía Regueiro; Maite López-López; Miguel González-Barcia; María Isabel Lema; Francisco Javier Otero-Espinar. "Design, Optimization, and Characterization of Lactoferrin-Loaded Chitosan/TPP and Chitosan/Sulfobutylether-ß-cyclodextrin Nanoparticles as a Pharmacological Alternative for Keratoconus Treatment". ACS Applied Materials & Interfaces (2021): https://doi.org/10.1021/acsami.0c18926.
    10.1021/acsami.0c18926
  40. Xurxo Garcia-Otero; Victoria Díaz Tomé; Rubén Varela-Fernández; Manuel Martín-Pastor; Miguel González-Barcia; José Blanco Méndez; Cristina Mondelo-García; et al. "Development and Characterization of a Tacrolimus/Hydroxypropyl-ß-Cyclodextrin Eye Drop". Pharmaceutics (2021): https://www.mdpi.com/1999-4923/13/2/149.
    10.3390/pharmaceutics13020149
  41. Varela-Fernández, R.; Lema-Gesto, M.I.; González-Barcia, M.; Otero-Espinar, F.J.. "Design, development, and characterization of an idebenone-loaded poly-e-caprolactone intravitreal implant as a new therapeutic approach for LHON treatment". European Journal of Pharmaceutics and Biopharmaceutics 168 (2021): 195-207. http://www.scopus.com/inward/record.url?eid=2-s2.0-85115015543&partnerID=MN8TOARS.
    10.1016/j.ejpb.2021.09.001
  42. Mondelo-García, C.; Bandín-Vilar, E.; García-Quintanilla, L.; Castro-Balado, A.; del Amo, E.M.; Gil-Martínez, M.; Blanco-Teijeiro, M.J.; et al. "Current Situation and Challenges in Vitreous Substitutes". Macromolecular Bioscience 21 8 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85105972063&partnerID=MN8TOARS.
    10.1002/mabi.202100066
  43. Conde Penedo, A.; Díaz Tomé, V.; Fernández Ferreiro, A.; González Barcia, M.; Otero Espinar, F.J.. "Enhancement in corneal permeability of riboflavin using cyclodextrin derivates complexes as a previous step to transepithelial cross-linking". European Journal of Pharmaceutics and Biopharmaceutics 162 (2021): 12-22. http://www.scopus.com/inward/record.url?eid=2-s2.0-85102075112&partnerID=MN8TOARS.
    10.1016/j.ejpb.2021.02.012
  44. Krambeck, K.; Silva, V.; Silva, R.; Fernandes, C.; Cagide, F.; Borges, F.; Santos, D.; et al. "Design and characterization of Nanostructured lipid carriers (NLC) and Nanostructured lipid carrier-based hydrogels containing Passiflora edulis seeds oil". International Journal of Pharmaceutics 600 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85102553849&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2021.120444
  45. Herbada, R.S.; Torres-Suárez, A.I.; Otero-Espinar, F.J.; Fraguas-Sanchez, A.I.; Lopez-Cabarcos, E.; Rubio-Retama, J.; Fernández-Carballido, A.. "Matrix tablets based on a novel poly (magnesium acrylate) hydrogel for the treatment of inflammatory bowel diseases". International Journal of Pharmaceutics 608 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85115969922&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2021.121121
  46. Víctor J. Álvarez; Susana B. Bravo; Maria Pilar Chantada-Vazquez; Cristóbal Colón; María J. De Castro; Montserrat Morales; Isidro Vitoria; et al. "Characterization of New Proteomic Biomarker Candidates in Mucopolysaccharidosis Type IVA". International Journal of Molecular Sciences 22 1 (2020): 226-226. https://doi.org/10.3390/ijms22010226.
    10.3390/ijms22010226
  47. Iria Seoane-Viaño; Noemí Gómez-Lado; Héctor Lázare-Iglesias; Xurxo García-Otero; José Ramón Antúnez-López; Álvaro Ruibal; Juan Jesús Varela-Correa; et al. "3D Printed Tacrolimus Rectal Formulations Ameliorate Colitis in an Experimental Animal Model of Inflammatory Bowel Disease". Biomedicines 8 12 (2020): 563-563. https://doi.org/10.3390/biomedicines8120563.
    10.3390/biomedicines8120563
  48. Ana Castro Balado; Cristina Mondelo-García; Iria Varela-Rey; Beatriz Moreda-Vizcaíno; Jesús F. Sierra-Sánchez; María Teresa Rodríguez-Ares; Gonzalo Hermelo-Vidal; et al. "Recent Research in Ocular Cystinosis: Drug Delivery Systems, Cysteamine Detection Methods and Future Perspectives". Pharmaceutics (2020): https://www.mdpi.com/1999-4923/12/12/1177.
    10.3390/pharmaceutics12121177
  49. Francisco Fernández-Campos; Francesc Navarro; Adrian Corrales; Jordi Picas; Eloy Pena; Jordi González; Francisco J. Otero-Espinar. "Transungual Delivery, Anti-Inflammatory Activity, and In Vivo Assessment of a Cyclodextrin Polypseudorotaxanes Nail Lacquer". Pharmaceutics 12 8 (2020): 730-730. https://doi.org/10.3390/pharmaceutics12080730.
    10.3390/pharmaceutics12080730
  50. Roseline Mazet; Xurxo García-Otero; Luc Choisnard; Denis Wouessidjewe; Vincent Verdoot; Frédéric Bossard; Victoria Díaz-Tomé; et al. "Biopharmaceutical Assessment of Dexamethasone Acetate-Based Hydrogels Combining Hydroxypropyl Cyclodextrins and Polysaccharides for Ocular Delivery". Pharmaceutics 12 8 (2020): 717-717. https://doi.org/10.3390/pharmaceutics12080717.
    10.3390/pharmaceutics12080717
  51. Cristina Moles-Aranda; Ana C. Calpena-Campmany; Lyda Halbaut-Bellowa; Victoria Díaz-Tomé; Francisco J. Otero-Espinar; José A. Morales-Molina; Beatriz Clares-Naveros. "Novel Polymeric Formulation for Removal of Gastrointestinal Polyps by Digestive Endoscopy". Pharmaceutics 12 4 (2020): 322-322. https://doi.org/10.3390/pharmaceutics12040322.
    10.3390/pharmaceutics12040322
  52. Rubén Varela-Fernández; Victoria Díaz-Tomé; Andrea Luaces-Rodríguez; Andrea Conde-Penedo; Xurxo García-Otero; Asteria Luzardo-Álvarez; Anxo Fernández-Ferreiro; Francisco J. Otero-Espinar. "Drug Delivery to the Posterior Segment of the Eye: Biopharmaceutic and Pharmacokinetic Considerations". Pharmaceutics (2020): https://doi.org/10.3390/pharmaceutics12030269.
    10.3390/pharmaceutics12030269
  53. Sara Blanco-Dorado; Maria Dolores Belles Medall; Oscar Pascual-Marmaneu; Manuel Campos-Toimil; Francisco Javier Otero-Espinar; Rafael Rodríguez-Riego; Teresa Rodríguez-Jato; et al. "Therapeutic drug monitoring of voriconazole: validation of a high performance liquid chromatography method and comparison with an ARK immunoassay". European Journal of Hospital Pharmacy (2020): https://doi.org/10.1136/ejhpharm-2019-002155.
    10.1136/ejhpharm-2019-002155
  54. Espinar, Francisco. "A multicenter prospective study evaluating the impact of Proton Pump Inhibitors omeprazole and pantoprazole on voriconazole plasma concentrations". British Journal of Clinical Pharmacology n/a n/a (2020): https://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bcp.14267.
    10.1111/bcp.14267
  55. Kazuki Sawamoto; José Álvarez González; Matthew Piechnik; Francisco Otero; Maria Couce; Yasuyuki Suzuki; Shunji Tomatsu. "Mucopolysaccharidosis IVA: Diagnosis, Treatment, and Management". International Journal of Molecular Sciences 21 4 (2020): 1517-1517. https://doi.org/10.3390/ijms21041517.
    10.3390/ijms21041517
  56. Blanco-Dorado, S.; Maroñas, O.; Latorre-Pellicer, A.; Rodríguez Jato, M.T.; López-Vizcaíno, A.; Gómez Márquez, A.; Bardán García, B.; et al. "Impact of CYP2C19 Genotype and Drug Interactions on Voriconazole Plasma Concentrations: A Spain Pharmacogenetic-Pharmacokinetic Prospective Multicenter Study". Pharmacotherapy 40 1 (2020): 17-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-85077792976&partnerID=MN8TOARS.
    10.1002/phar.2351
  57. Luaces-Rodríguez, A.; Mondelo-García, C.; Zarra-Ferro, I.; González-Barcia, M.; Aguiar, P.; Fernández-Ferreiro, A.; Otero-Espinar, F.J.. "Intravitreal anti-VEGF drug delivery systems for age-related macular degeneration". International Journal of Pharmaceutics 573 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85076213292&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2019.118767
  58. Espinar, Francisco. "Optimization of Drug Permeation from 8% Ciclopirox Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers". Pharmaceutics (2020): https://www.mdpi.com/1999-4923/12/3/231.
    10.3390/pharmaceutics12030231
  59. Tavares, W.S.; Tavares-Júnior, A.G.; Otero-Espinar, F.J.; Martín-Pastor, M.; Sousa, F.F.O.. "Design of ellagic acid-loaded chitosan/zein films for wound bandaging". Journal of Drug Delivery Science and Technology 59 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85088221745&partnerID=MN8TOARS.
    10.1016/j.jddst.2020.101903
  60. Seoane-Viaño, I.; Ong, J.J.; Luzardo-Álvarez, A.; González-Barcia, M.; Basit, A.W.; Otero-Espinar, F.J.; Goyanes, A.. "3D printed tacrolimus suppositories for the treatment of ulcerative colitis". Asian Journal of Pharmaceutical Sciences (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85090344780&partnerID=MN8TOARS.
    10.1016/j.ajps.2020.06.003
  61. Sawamoto, K.; Álvarez, J.V.; Herreño, A.M.; Otero-Espinar, F.J.; Couce, M.L.; Alméciga-Díaz, C.J.; Tomatsu, S.. "Bone-Specific Drug Delivery for Osteoporosis and Rare Skeletal Disorders". Current Osteoporosis Reports 18 5 (2020): 515-525. http://www.scopus.com/inward/record.url?eid=2-s2.0-85089908614&partnerID=MN8TOARS.
    10.1007/s11914-020-00620-4
  62. Krambeck, K.; Santos, D.; Otero-Espinar, F.; Sousa Lobo, J.M.; Amaral, M.H.. "Lipid nanocarriers containing Passiflora edulis seeds oil intended for skin application". Colloids and Surfaces B: Biointerfaces 193 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85084184479&partnerID=MN8TOARS.
    10.1016/j.colsurfb.2020.111057
  63. Luaces-Rodríguez, A.; del Amo, E.M.; Mondelo-García, C.; Gómez-Lado, N.; Gonzalez, F.; Ruibal, Á.; González-Barcia, M.; et al. "PET study of ocular and blood pharmacokinetics of intravitreal bevacizumab and aflibercept in rats". European Journal of Pharmaceutics and Biopharmaceutics 154 (2020): 330-337. http://www.scopus.com/inward/record.url?eid=2-s2.0-85088986290&partnerID=MN8TOARS.
    10.1016/j.ejpb.2020.06.024
  64. J. Álvarez; Carolina Herrero Filgueira; Alexandre González; Cristóbal Colón Mejeras; Andrés Beiras Iglesias; Shunji Tomatsu; José Blanco Méndez; et al. "Enzyme-Loaded Gel Core Nanostructured Lipid Carriers to Improve Treatment of Lysosomal Storage Diseases: Formulation and In Vitro Cellular Studies of Elosulfase Alfa-Loaded Systems". Pharmaceutics 11 10 (2019): 522-522. https://doi.org/10.3390/pharmaceutics11100522.
    10.3390/pharmaceutics11100522
  65. J. Víctor Álvarez; Susana B. Bravo; María García-Vence; María J. De Castro; Asteria Luzardo; Cristóbal Colón; Shunji Tomatsu; Francisco J. Otero-Espinar; María L. Couce. "Proteomic Analysis in Morquio A Cells Treated with Immobilized Enzymatic Replacement Therapy on Nanostructured Lipid Systems". International Journal of Molecular Sciences (2019): https://doi.org/10.3390/ijms20184610.
    10.3390/ijms20184610
  66. Lucía Álvarez-Álvarez; Luis Barral; Rebeca Bouza; Yousof Farrag; Francisco Otero-Espinar; Sandra Feijóo-Bandín; Francisca Lago. "Hydrocortisone loaded poly-(3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles for topical ophthalmic administration: Preparation, characterization and evaluation of ophthalmic toxicity". International Journal of Pharmaceutics 568 (2019): 118519-118519. https://doi.org/10.1016/j.ijpharm.2019.118519.
    10.1016/j.ijpharm.2019.118519
  67. Laura García-Quintanilla; Andrea Luaces-Rodríguez; María Gil-Martínez; Cristina Mondelo-García; Olalla Maroñas; Víctor Mangas-Sanjuan; Miguel González-Barcia; et al. "Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration". Pharmaceutics 11 8 (2019): 365-365. https://doi.org/10.3390/pharmaceutics11080365.
    10.3390/pharmaceutics11080365
  68. Asteria Luzardo-Álvarez; Iván Lamela-Gómez; Francisco Otero-Espinar; José Blanco-Méndez. "Development, Characterization, and In Vitro Evaluation of Resveratrol-Loaded Poly-(e-caprolactone) Microcapsules Prepared by Ultrasonic Atomization for Intra-Articular Administration". Pharmaceutics 11 6 (2019): 249-249. https://doi.org/10.3390/pharmaceutics11060249.
    10.3390/pharmaceutics11060249
  69. Zulema Vargas-Osorio; Asteria Luzardo-Álvarez; Yolanda Piñeiro; Carlos Vázquez-Vázquez; J. Luis Gómez-Amoza; José Blanco-Méndez; Francisco J. Otero Espinar; José Rivas. "Three-Dimensional Hybrid Mesoporous Scaffolds for Simvastatin Sustained Delivery with in Vitro Cell Compatibility". ACS Omega (2019): https://doi.org/10.1021/acsomega.8b03676.
    10.1021/acsomega.8b03676
  70. Mariño-López, A.; Sousa-Castillo, A.; Carbó-Argibay, E.; Otero-Espinar, F.; Alvarez-Puebla, R.A.; Pérez-Lorenzo, M.; Correa-Duarte, M.A.. "Laser-protective soft contact lenses: Keeping an eye on the eye through plasmonics". Applied Materials Today 15 (2019): 1-5. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059304572&partnerID=MN8TOARS.
    10.1016/j.apmt.2018.12.016
  71. Campaña-Seoane, M.; Pérez-Gago, A.; Vázquez, G.; Conde, N.; González, P.; Martinez, A.; Martínez, X.; et al. "Vaginal residence and pharmacokinetic preclinical study of topical vaginal mucoadhesive W/S emulsions containing ciprofloxacin". International Journal of Pharmaceutics 554 (2019): 276-283. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056449734&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2018.11.022
  72. Seoane-Viaño, I.; Gómez-Lado, N.; Lázare-Iglesias, H.; Rey-Bretal, D.; Lamela-Gómez, I.; Otero-Espinar, F.J.; Blanco-Méndez, J.; et al. "Evaluation of the therapeutic activity of melatonin and resveratrol in Inflammatory Bowel Disease: A longitudinal PET/CT study in an animal model". International Journal of Pharmaceutics 572 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85073689176&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2019.118713
  73. Romero, V.; Lara, J.R.; Otero-Espinar, F.; Salgado, M.H.; Modolo, N.S.P.; Barros, G.A.M.D.. "Capsaicin topical cream (8%) for the treatment of myofascial pain syndrome,Creme tópico de capsaicina (8%) para o tratamento da síndrome da dor miofascial". Brazilian Journal of Anesthesiology (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071985370&partnerID=MN8TOARS.
    10.1016/j.bjan.2019.06.008
  74. Martínez-Casal, X.; Rodriguez-Sánchez, J.L.; Otero-Espinar, F.J.. "Budget impact analysis of two pharmaceutical management models in relation to the administration of intravenous anti-infective therapy in a Spanish nursing home". European Journal of Hospital Pharmacy (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071447341&partnerID=MN8TOARS.
    10.1136/ejhpharm-2019-001989
  75. Espinar, Francisco. "Ocular Biodistribution Studies Using Molecular Imaging". Pharmaceutics (2019): https://www.mdpi.com/1999-4923/11/5/237.
    10.3390/pharmaceutics11050237
  76. Barbara S. Gregorí Valdes; Ana Paula Serro; Joana Marto; Rui Galhano dos Santos; Elena Cutrín Gómez; Francisco Javier Otero Espinar; João Moura Bordado; Helena Ribeiro. "Polyurethanes as New Excipients in Nail Therapeutics". Pharmaceutics (2018): http://www.mdpi.com/1999-4923/10/4/276.
    10.3390/pharmaceutics10040276
  77. Elena Cutrín-Gómez; Soledad Anguiano-Igea; Given Names Deactivated Family Name Deactivated; Jose Luis Gomez-Amoza; Francisco Javier Otero Espinar. "Effect of Penetration Enhancers on Drug Nail Permeability from Cyclodextrin/Poloxamer-Soluble Polypseudorotaxane-Based Nail Lacquers". Pharmaceutics (2018): http://www.mdpi.com/1999-4923/10/4/273.
    10.3390/pharmaceutics10040273
  78. Carlos Fernandes; Cláudia Martins; André Fonseca; Rute Nunes; Maria João Matos; Renata Silva; Jorge Garrido; et al. "PEGylated PLGA Nanoparticles As a Smart Carrier to Increase the Cellular Uptake of a Coumarin-Based Monoamine Oxidase B Inhibitor". ACS Applied Materials & Interfaces (2018): https://doi.org/10.1021/acsami.8b17224.
    10.1021/acsami.8b17224
  79. Elena Cutrín-Gómez; Soledad Anguiano-Igea; Given Names Deactivated Family Name Deactivated; Jose Luis Gomez-Amoza; Francisco Javier Otero Espinar. "Effect on Nail Structure and Transungual Permeability of the Ethanol and Poloxamer Ratio from Cyclodextrin-Soluble Polypseudorotaxanes Based Nail Lacquer". Pharmaceutics (2018): http://www.mdpi.com/1999-4923/10/3/156.
    10.3390/pharmaceutics10030156
  80. Seoane-Viaño I; Gómez-Lado N; Lázare-Iglesias H; Barreiro-de Acosta M; Silva-Rodríguez J; Luzardo-Álvarez A; Herranz M; Otero-Espinar F; Ruibal Á. "Longitudinal PET/CT evaluation of TNBS-induced inflammatory bowel disease rat model.". International journal of pharmaceutics (2018): http://europepmc.org/abstract/med/30081226.
    10.1016/j.ijpharm.2018.08.005
  81. Andrea Luaces-Rodríguez; Rosario Touriño-Peralba; Iria Alonso-Rodríguez; Xurxo García-Otero; Miguel González-Barcia; María Teresa Rodríguez-Ares; Laura Martínez-Pérez; et al. "Preclinical characterization and clinical evaluation of tacrolimus eye drops". European Journal of Pharmaceutical Sciences 120 (2018): 152-161. https://doi.org/10.1016%2Fj.ejps.2018.04.038.
    10.1016/j.ejps.2018.04.038
  82. Espinar, Francisco. "Review of Intraocular Pharmacokinetics of Anti-Infectives Commonly Used in the Treatment of Infectious Endophthalmitis". Pharmaceutics (2018): http://www.mdpi.com/1999-4923/10/2/66.
    10.3390/pharmaceutics10020066
  83. Victoria Díaz-Tomé; Andrea Luaces-Rodríguez; Jesús Silva-Rodríguez; Sara Blanco-Dorado; Laura García-Quintanilla; José Llovo-Taboada; José Blanco-Méndez; et al. "Ophthalmic Econazole Hydrogels for the Treatment of Fungal Keratitis". Journal of Pharmaceutical Sciences 107 5 (2018): 1342-1351. https://doi.org/10.1016%2Fj.xphs.2017.12.028.
    10.1016/j.xphs.2017.12.028
  84. Elena Cutrín Gómez; Soledad Anguiano Igea; José Luis Gómez Amoza; Francisco J. Otero Espinar. "Evaluation of the promoting effect of soluble cyclodextrins in drug nail penetration". European Journal of Pharmaceutical Sciences 117 (2018): 270-278. https://doi.org/10.1016/j.ejps.2018.02.028.
    10.1016/j.ejps.2018.02.028
  85. Elena Cutrín Gómez; Soledad Anguiano Igea; M. Begoña Delgado-Charro; José Luis Gómez Amoza; Francisco J. Otero Espinar. "Microstructural alterations in the onychomycotic and psoriatic nail: relevance in drug delivery". European Journal of Pharmaceutics and Biopharmaceutics (2018): https://doi.org/10.1016/j.ejpb.2018.04.012.
    10.1016/j.ejpb.2018.04.012
  86. Espinar, Francisco. "Ophthalmic Econazole Hydrogels for the Treatment of Fungal Keratitis". Journal of Pharmaceutical Sciences 107 5 (2018): 1342-1351. http://www.sciencedirect.com/science/article/pii/S0022354917309103.
    https://doi.org/10.1016/j.xphs.2017.12.028
  87. Espinar, Francisco. "Preclinical characterization and clinical evaluation of tacrolimus eye drops". European Journal of Pharmaceutical Sciences 120 (2018): 152-161. http://www.sciencedirect.com/science/article/pii/S0928098718302033.
    https://doi.org/10.1016/j.ejps.2018.04.038
  88. Fernández-Ferreiro A; Luaces-Rodríguez A; Díaz-Tomé V; Gil-Martínez M; Rodríguez Ares MT; Touriño Peralba R; Blanco-Méndez J; González-Barcia M; Lamas MJ. "[Cysteamine ophthalmic hydrogel for the treatment of ocular cystinosis].". Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria (2017): http://europepmc.org/abstract/med/29112493.
    10.7399/fh.10834
  89. Elena Villar López; Asteria Luzardo Álvarez; José Blanco Méndez; Francisco J. Otero Espinar. "Cellulose-polysaccharide film-coating of cyclodextrin based pellets for controlled drug release". Journal of Drug Delivery Science and Technology (2017): https://doi.org/10.1016%2Fj.jddst.2017.03.031.
    10.1016/j.jddst.2017.03.031
  90. Eva García-Millán; Mónica Quintáns-Carballo; Francisco Javier Otero-Espinar. "Improved release of triamcinolone acetonide from medicated soft contact lenses loaded with drug nanosuspensions". International Journal of Pharmaceutics (2017): https://doi.org/10.1016%2Fj.ijpharm.2017.03.082.
    10.1016/j.ijpharm.2017.03.082
  91. Fernández-Ferreiro A; Santiago-Varela M; Gil-Martínez M; González-Barcia M; Luaces-Rodríguez A; Díaz-Tome V; Pardo M; et al. "In Vitro Evaluation of the Ophthalmic Toxicity Profile of Chlorhexidine and Propamidine Isethionate Eye Drops.". (2017): http://europepmc.org/abstract/med/28384032.
    10.1089/jop.2016.0053
  92. García-Millán, E.; Quintáns-Carballo, M.; Otero-Espinar, F.J.. "Solid-state characterization of triamcinolone acetonide nanosuspensiones by X-ray spectroscopy, ATR Fourier transforms infrared spectroscopy and differential scanning calorimetry analysis". Data in Brief 15 (2017): 133-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029928365&partnerID=MN8TOARS.
    10.1016/j.dib.2017.09.002
  93. de Ocenda, V.-R.; Almeida-Prieto, S.; Luzardo-Álvarez, A.; Barja, J.L.; Otero-Espinar, F.J.; Blanco-Méndez, J.. "Pharmacokinetic model of florfenicol in turbot (Scophthalmus maximus): establishment of optimal dosage and administration in medicated feed". Journal of Fish Diseases 40 3 (2017): 411-424. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994631737&partnerID=MN8TOARS.
    10.1111/jfd.12525
  94. Fernández-Ferreiro, A.; Silva-Rodríguez, J.; Otero-Espinar, F.J.; González-Barcia, M.; Lamas, M.J.; Ruibal, A.; Luaces-Rodriguez, A.; et al. "Positron emission tomography for the development and characterization of corneal permanence of ophthalmic pharmaceutical formulations". Investigative Ophthalmology and Visual Science 58 2 (2017): 772-780. http://www.scopus.com/inward/record.url?eid=2-s2.0-85011580007&partnerID=MN8TOARS.
    10.1167/iovs.16-20766
  95. Fernández-Ferreiro, A.; Silva-Rodríguez, J.; Otero-Espinar, F.J.; González-Barcia, M.; Lamas, M.J.; Ruibal, A.; Luaces-Rodríguez, A.; et al. "In vivo eye surface residence determination by high-resolution scintigraphy of a novel ion-sensitive hydrogel based on gellan gum and kappa-carrageenan". European Journal of Pharmaceutics and Biopharmaceutics 114 (2017): 317-323. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013213067&partnerID=MN8TOARS.
    10.1016/j.ejpb.2017.01.023
  96. Blanco-García, E.; Otero-Espinar, F.J.; Blanco-Méndez, J.; Leiro-Vidal, J.M.; Luzardo-Álvarez, A.. "Development and characterization of anti-inflammatory activity of curcumin-loaded biodegradable microspheres with potential use in intestinal inflammatory disorders". International Journal of Pharmaceutics 518 1-2 (2017): 86-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-85007570696&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2016.12.057
  97. Luaces-Rodríguez, A.; Díaz-Tomé, V.; González-Barcia, M.; Silva-Rodríguez, J.; Herranz, M.; Gil-Martínez, M.; Rodríguez-Ares, M.T.; et al. "Cysteamine polysaccharide hydrogels: Study of extended ocular delivery and biopermanence time by PET imaging". International Journal of Pharmaceutics 528 1-2 (2017): 714-722. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021245430&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2017.06.060
  98. Fernández-Ferreiro, A.; Luaces-Rodríguez, A.; Aguiar, P.; Pardo-Montero, J.; González-Barcia, M.; García-Varela, L.; Herranz, M.; et al. "Preclinical PET study of intravitreal injections". Investigative Ophthalmology and Visual Science 58 7 (2017): 2843-2851. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020272293&partnerID=MN8TOARS.
    10.1167/iovs.17-21812
  99. Méndez, S.G.; Otero Espinar, F.J.; Alvarez, A.L.; Longhi, M.R.; Quevedo, M.A.; Zoppi, A.. "Ternary complexation of benzoic acid with ß-cyclodextrin and aminoacids. Experimental and theoretical studies". Journal of Inclusion Phenomena and Macrocyclic Chemistry 85 1-2 (2016): 33-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-84965170034&partnerID=MN8TOARS.
    10.1007/s10847-016-0603-6
  100. Fernández-Ferreiro, A.; González-Barcia, M.; Otero Espinar, F.J.; Blanco Méndez, J.; Lamas, M.J.. "Ophthalmic formulations new goals,Retos en la formulación magistral oftálmica". Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 40 1 (2016): 1-2. http://www.scopus.com/inward/record.url?eid=2-s2.0-85012027072&partnerID=MN8TOARS.
    10.7399/fh.2016.40.1.10417
  101. Fernández-Ferreiro, A.; González-Barcia, M.; Gil-Martínez, M.; Santiago-Varela, M.; Pardo, M.; Blanco-Méndez, J.; Piñeiro-Ces, A.; Lamas, M.J.; Otero-Espinar, F.J.. "Evaluation of the in vitro ocular toxicity of the fortified antibiotic eye drops prepared at the hospital pharmacy departments,Evaluación de la toxicidad ocular in vitro de los colirios fortificados antibióticos elaborados en los servicios de farmacia hospitalaria". Farmacia Hospitalaria 40 5 (2016): 352-370. http://www.scopus.com/inward/record.url?eid=2-s2.0-84984903213&partnerID=MN8TOARS.
    10.7399/fh.2016.40.5.10416
  102. A Fernández-Ferreiro; M Santiago-Varela; M Gil-Martínez; M Pardo-Perez; M González-Barcia; A Piñeiro-Ces; J Blanco-Mendez; MJ Lamas Díaz; F Otero-Espinar. "DI-023 Effect of different antifugal eye drops on human corneal cells in vitro". European Journal of Hospital Pharmacy 22 Suppl 1 (2015): A84.2-A84. https://doi.org/10.1136%2Fejhpharm-2015-000639.201.
    10.1136/ejhpharm-2015-000639.201
  103. Sánchez-Sánchez, M.-P.; Martín-Illana, A.; Ruiz-Caro, R.; Bermejo, P.; Abad, M.-J.; Carro, R.; Bedoya, L.-M.; et al. "Chitosan and Kappa-Carrageenan Vaginal Acyclovir Formulations for Prevention of Genital Herpes. In Vitro and Ex Vivo Evaluation". Marine Drugs 13 9 (2015): 5976-5992. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942845405&partnerID=MN8TOARS.
    10.3390/md13095976
  104. García-Millán, E.; Koprivnik, S.; Otero-Espinar, F.J.. "Drug loading optimization and extended drug delivery of corticoids from pHEMA based soft contact lenses hydrogels via chemical and microstructural modifications". International Journal of Pharmaceutics 487 1-2 (2015): 260-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928158524&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2015.04.037
  105. Fernández-Ferreiro, A.; Santiago-Varela, M.; Gil-Martínez, M.; Parada, T.G.-C.; Pardo, M.; González-Barcia, M.; Piñeiro-Ces, A.; et al. "Ocular safety comparison of non-steroidal anti-inflammatory eye drops used in pseudophakic cystoid macular edema prevention". International Journal of Pharmaceutics 495 2 (2015): 680-691. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944040291&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2015.09.058
  106. Fernández-Ferreiro, A.; González Barcia, M.; Gil-Martínez, M.; Vieites-Prado, A.; Lema, I.; Argibay, B.; Blanco Méndez, J.; Lamas, M.J.; Otero-Espinar, F.J.. "In vitro and in vivo ocular safety and eye surface permanence determination by direct and Magnetic Resonance Imaging of ion-sensitive hydrogels based on gellan gum and kappa-carrageenan". European Journal of Pharmaceutics and Biopharmaceutics 94 (2015): 342-351. http://www.scopus.com/inward/record.url?eid=2-s2.0-84935028253&partnerID=MN8TOARS.
    10.1016/j.ejpb.2015.06.003
  107. Fernandez-Ferreiro, A; Gonzalez Barcia, M; Gil Martinez, M; Blanco Mendez, J; Lamas Diaz, M J; Otero Espinar, F J. "[Analysis of ocular toxicity of fluconazole and voriconazole eyedrops using HET-CAM].". Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 38 4 (2014): 300-4.
    10.7399/fh.2014.38.4.7343
  108. Espinar, Francisco. "Cyclodextrin based rotaxanes, polyrotaxanes and polypseudorotaxanes and their biomedical applications.". Current Topics in Medicinal Chemistry (2014): http://europepmc.org/abstract/med/24354671.
    10.2174/1568026613666131219123910
  109. Espinar, Francisco. "Cyclodextrin-based polysaccharidic polymers: an approach for the drug delivery.". Current Topics in Medicinal Chemistry (2014): http://europepmc.org/abstract/med/24354666.
    10.2174/1568026613666131219125419
  110. Espinar, Francisco. "Natural & synthetically-modified cyclodextrins and polymers in drug delivery systems.". Current Topics in Medicinal Chemistry (2014): http://europepmc.org/abstract/med/24354673.
    10.2174/1568026613666131219122902
  111. Fernández-Ferreiro, A.; Bargiela, N.F.; Varela, M.S.; Martínez, M.G.; Pardo, M.; Ces, A.P.; Méndez, J.B.; et al. "Cyclodextrin-polysaccharide-based, in situ-gelled system for ocular antifungal delivery". Beilstein Journal of Organic Chemistry 10 (2014): 2903-2911. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920083379&partnerID=MN8TOARS.
    10.3762/bjoc.10.308
  112. Campaña-Seoane, M.; Peleteiro, A.; Laguna, R.; Otero-Espinar, F.J.. "Bioadhesive emulsions for control release of progesterone resistant to vaginal fluids clearance". International Journal of Pharmaceutics 477 1-2 (2014): 495-505. http://www.scopus.com/inward/record.url?eid=2-s2.0-84910030490&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2014.10.066
  113. Fernández Ferreiro, A.; González Barcia, M.; Gil Martínez, M.; Alba Domínguez, J.; Otero Espinar, F.J.; Blanco Méndez, J.; Harriet Romero, R.E.; Lamas Díaz, M.J.. "Use of fortified antibiotic eye drops on eye infections". Atencion Farmaceutica 16 4 (2014): 296-299. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908351396&partnerID=MN8TOARS.
  114. Fernández-Ferreiro, A.; González Barcia, M.; Gil Martínez, M.; Blanco Mendez, J.; Lamas Díaz, M.J.; Otero Espinar, F.J.. "Analysis of ocular toxicity of fluconazole and voriconazole eyedrops using HET CAM,Análisis de la toxicidad ocular de los colirios de voriconazol y fluconazol con HET-CAM". Farmacia Hospitalaria 38 4 (2014): 300-304. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906089406&partnerID=MN8TOARS.
    10.7399/FH.2014.38.4.7343
  115. Nogueiras-Nieto, Luis; Delgado-Charro, M. Begona; Otero-Espinar, Francisco J.. "Thermogelling hydrogels of cyclodextrin/poloxamer polypseudorotaxanes as aqueous-based nail lacquers: Application to the delivery of triamcinolone acetonide and ciclopirox olamine". European Journal of Pharmaceutics and Biopharmaceutics 83 3 (2013): 370-377.
    10.1016/j.ejpb.2012.11.004
  116. Espinar, Francisco. "Use of 1H NMR STD, WaterLOGSY, and Langmuir monolayer techniques for characterization of drug-zein protein complexes". European Journal of Pharmaceutics and Biopharmaceutics 85 3 PART A (2013): 790-798. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888381697&partnerID=MN8TOARS.
    10.1016/j.ejpb.2013.07.008
  117. Ruiz-Caro R; Gago-Guillan M; Otero-Espinar FJ; Veiga MD. "Mucoadhesive tablets for controlled release of acyclovir.". Chemical & pharmaceutical bulletin (2012): http://europepmc.org/abstract/med/22863800.
    10.1248/cpb.c12-00324
  118. Nogueiras-Nieto, Luis; Sobarzo-Sanchez, Eduardo; Luis Gomez-Amoza, Jose; Otero-Espinar, Francisco J.. "Competitive displacement of drugs from cyclodextrin inclusion complex by polypseudorotaxane formation with poloxamer: Implications in drug solubilization and delivery". European Journal of Pharmaceutics and Biopharmaceutics 80 3 (2012): 585-595.
    10.1016/j.ejpb.2011.12.001
  119. Folch-Cano, Christian; Olea-Azar, Claudio; Sobarzo-Sanchez, Eduardo; Alvarez-Lorenzo, Carmen; Concheiro, Angel; Otero, Francisco; Jullian, Carolina. "Inclusion Complex of 4-Hydroxycoumarin with Cyclodextrins and Its Characterization in Aqueous Solution". Journal of Solution Chemistry 40 11 (2011): 1835-1846.
    10.1007/s10953-011-9760-9
  120. Nogueiras-Nieto, L.; Gomez-Amoza, J. L.; Delgado-Charro, M. B.; Otero-Espinar, F. J.. "Hydration and N-acetyl-l-cysteine alter the microstructure of human nail and bovine hoof: Implications for drug delivery". Journal of Controlled Release 156 3 (2011): 337-344.
    10.1016/j.jconrel.2011.08.021
  121. Alvarez AL; Espinar FO; Méndez JB. "The application of microencapsulation techniques in the treatment of endodontic and periodontal diseases.". (2011): http://europepmc.org/abstract/med/24310596.
    10.3390/pharmaceutics3030538
  122. Luzardo-Alvarez, A.; Otero-Espinar, F.J.; Blanco-Méndez, J.. "Microencapsulation of diets and vaccines for cultured fishes, crustaceans and bivalve mollusks". Journal of Drug Delivery Science and Technology 20 4 (2010): 277-288. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149376361&partnerID=MN8TOARS.
    10.1016/S1773-2247(10)50045-5
  123. Otero-Espinar, F.J.; Torres-Labandeira, J.J.; Alvarez-Lorenzo, C.; Blanco-Méndez, J.. "Cyclodextrins in drug delivery systems". Journal of Drug Delivery Science and Technology 20 4 (2010): 289-301. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149392568&partnerID=MN8TOARS.
    10.1016/S1773-2247(10)50046-7
  124. Otero-Espinar, F.J.; Luzardo-Alvarez, A.; Blanco-Méndez, J.. "Non-MCC materials as extrusion-spheronization aids in pellets production". Journal of Drug Delivery Science and Technology 20 4 (2010): 303-318. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149403812&partnerID=MN8TOARS.
    10.1016/S1773-2247(10)50047-9
  125. F.J. Otero-Espinar; J.J. Torres-Labandeira; C. Alvarez-Lorenzo; J. Blanco-Méndez. "Cyclodextrins in drug delivery systems". Journal of Drug Delivery Science and Technology 20 4 (2010): 289-301. https://doi.org/10.1016%2Fs1773-2247%2810%2950046-7.
    10.1016/s1773-2247(10)50046-7
  126. F.J. Otero-Espinar; A. Luzardo-Alvarez; J. Blanco-Méndez. "Non-MCC materials as extrusion-spheronization aids in pellets production". Journal of Drug Delivery Science and Technology 20 4 (2010): 303-318. https://doi.org/10.1016%2Fs1773-2247%2810%2950047-9.
    10.1016/s1773-2247(10)50047-9
  127. Otero-Espinar, F.J.; Luzardo-Álvarez, A.; Blanco-Méndez, J.. "Cyclodextrins: More than pharmaceutical excipients". Mini-Reviews in Medicinal Chemistry 10 8 (2010): 715-725. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954719737&partnerID=MN8TOARS.
    10.2174/138955710791572479
  128. Otero Espinar, F.J.; Alvarez Lorenzo, C.. "Adaptation of biopharmaceutics and pharmacokinetics to the EHEA in the new grade of pharmacy at the University of Santiago de Compostela,Adaptación de la materia biofarmacia y farmacocinética al EEES en el nuevo grado de farmacia de la Universidad de Santiago de Compostela". Ars Pharmaceutica 51 SUPPL. 2 (2010): 498-504. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954988977&partnerID=MN8TOARS.
  129. Alvarez-Lorenzo, C.; Otero-Espinar, F.. "The students set their own exam: An opportunity for learning to learn,Los alumnos ponen el examen: Una oportunidad para aprender a aprender". Ars Pharmaceutica 51 SUPPL. 2 (2010): 494-497. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955035367&partnerID=MN8TOARS.
  130. A. Luzardo-Alvarez; F.J. Otero-Espinar; J. Blanco-Méndez. "Microencapsulation of diets and vaccines for cultured fishes, crustaceans and bivalve mollusks". Journal of Drug Delivery Science and Technology 20 4 (2010): 277-288. https://doi.org/10.1016%2Fs1773-2247%2810%2950045-5.
    10.1016/s1773-2247(10)50045-5
  131. Nogueiras-Nieto, Luis; Alvarez-Lorenzo, Carmen; Sandez-Macho, Isabel; Concheiro, Angel; Otero-Espinar, Francisco J.. "Hydrosoluble Cyclodextrin/Poloxamer Polypseudorotaxanes at the Air/Water Interface, in Bulk Solution, and in the Gel State". Journal of Physical Chemistry B 113 9 (2009): 2773-2782.
    10.1021/jp809806w
  132. Sergio, Almeida-Prieto; Cristiana Isabel, de Sa Ferreira da Rocha; Jose, Blanco-Mendez; Otero-Espinar, Francisco J.. "Fast and controlled release of triamcinolone acetonide from extrusion-spheronization pellets based on mixtures of native starch with dextrin or waxy maize starch". Drug Development and Industrial Pharmacy 33 9 (2007): 945-951.
    10.1080/03639040601128720
  133. Almeida-Prieto, Sergio; Blanco-Mendez, Jose; Otero-Espinar, Francisco J.. "Microscopic image analysis techniques for the morphological characterization of pharmaceutical particles: Influence of the software, and the factor algorithms used in the shape factor estimation". European Journal of Pharmaceutics and Biopharmaceutics 67 3 (2007): 766-776.
    10.1016/j.ejpb.2007.04.001
  134. Almeida-Prieto, S; Blanco-Mendez, J; Otero-Espinar, FJ. "Microscopic image analysis techniques for the morphological characterization of pharmaceutical particles: Influence of process variables". Journal of Pharmaceutical Sciences 95 2 (2006): 348-357.
    10.1002/jps.20507
  135. Siemoneit, U; Schmitt, C; Alvarez-Lorenzo, C; Luzardo, A; Otero-Espinar, F; Concheiro, A; Blanco-Mendez, J. "Acrylic/cyclodextrin hydrogels with enhanced drug loading and sustained release capability". International Journal of Pharmaceutics 312 1-2 (2006): 66-74.
    10.1016/j.ijpharm.2005.12.046
  136. Luzardo-Alvarez, A.; Almeida-Prieto, S.; Fraga-Lopez, F.; Otero-Espinar, F.; Rodriguez-Nunez, E.; Martinez-Ageitos, J.; Blanco-Mendez, J.. "Effect of formulation variables on the prediction of release from microparticles with experimental design". Journal of Applied Polymer Science 102 5 (2006): 4546-4553.
    10.1002/app.24960
  137. Almeida Prieto, S; Blanco Mendez, J; Otero Espinar, F J. "Starch-dextrin mixtures as base excipients for extrusion-spheronization pellets.". European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 59 3 (2005): 511-21.
    10.1016/j.ejpb.2004.09.010
  138. Castro-Hermida, JA; Gomez-Couso, H; Ares-Mazas, ME; Gonzalez-Edia, MM; Castaneda-Cancio, N; Otero-Espinar, FJ; Blanco-Mendez, J. "Anticryptosporidial activity of furan derivative G1 and its inclusion complex with beta-cyclodextrin". Journal of Pharmaceutical Sciences 93 1 (2004): 197-206.
    10.1002/jps.10528
  139. Castro-Hermida, JA; Pors, I; Otero-Espinar, F; Luzardo-Alvarez, A; Ares-Mazas, E; Chartier, C. "Efficacy of alpha-cyclodextrin against experimental cryptosporidiosis in neonatal goats". Veterinary Parasitology 120 1-2 (2004): 35-41.
    10.1016/j.vetpar.2003.12.012
  140. Almeida-Prieto, S; Blanco-Mendez, J; Otero-Espinar, FJ. "Image analysis of the shape of granulated powder grains". Journal of Pharmaceutical Sciences 93 3 (2004): 621-634.
    10.1002/jps.10572
  141. A Luzardo-Álvarez; J Marti´nez-Mazagatos; M.T Santamarina-Fernández; F.J Otero-Espinar; J Blanco-Méndez. "Oral pharmacological treatments for ichthyophthiriosis of rainbow trout (Oncorhynchus mykiss)". Aquaculture 220 1-4 (2003): 15-25. https://doi.org/10.1016%2Fs0044-8486%2802%2900228-4.
    10.1016/s0044-8486(02)00228-4
  142. Luzardo-Alvarez, A; Martinez-Mazagatos, J; Santamarina-Fernandez, MT; Otero-Espinar, FJ; Blanco-Mendez, J. "Oral pharmacological treatments for ichthyophthiriosis of rainbow trout (Oncorhynchus mykiss)". Aquaculture 220 1-4 (2003): 15-25.
    10.1016/S0044-8486(02)00228-4
  143. Ganza-González, A.; Anguiano-Igea, S.; Otero-Espinar, F.J.; Blanco Méndez, J.; Buri, P.. "Polyacrylate-based microparticles for sustained release of metoclopramide". S.T.P. Pharma Sciences 12 2 (2002): 103-107. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036231320&partnerID=MN8TOARS.
  144. Blanco-Fuente, H; Esteban-Fernandez, B; Blanco-Mendez, J; Otero-Espinar, FJ. "Use of beta-cyclodextrins to prevent modifications of the properties of Carbopol hydrogels due to Carbopol-drug interactions". Chemical & Pharmaceutical Bulletin 50 1 (2002): 40-46.
    10.1248/cpb.50.40
  145. Castro Hermida, J.A.; Ares-Mazás, M.E.; Otero Espinar, F.; Blanco Méndez, J.; Nieto Reyes, L.. "Inhibition of Cryptosporidium infection in mice treated with a cyclodextrin inclusion complex with diloxanide furoate". Parasitology Research 87 6 (2001): 449-452. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035033241&partnerID=MN8TOARS.
    10.1007/s004360000359
  146. A. Ganza-González; S. Anguiano-Igea; F.J. Otero-Espinar; J. Blanco Méndez. "Chitosan and chondroitin microspheres for oral-administration controlled release of metoclopramide". European Journal of Pharmaceutics and Biopharmaceutics 48 2 (1999): 149-155. https://doi.org/10.1016%2Fs0939-6411%2899%2900040-5.
    10.1016/s0939-6411(99)00040-5
  147. Villar-Lopez, ME; Nieto-Reyes, L; Anguiano-Igea, S; Otero-Espinar, EJ; Blanco-Mendez, J. "Formulation of triamcinolone acetonide pellets suitable for coating and colon targeting". International Journal of Pharmaceutics 179 2 (1999): 229-235.
    10.1016/S0378-5173(98)00369-X
  148. Ganza-Gonzalez, A; Anguiano-Igea, S; Otero-Espinar, FJ; Mendez, JB. "Chitosan and chondroitin microspheres for oral-administration controlled release of metoclopramide". European Journal of Pharmaceutics and Biopharmaceutics 48 2 (1999): 149-155.
    10.1016/S0939-6411(99)00040-5
  149. Debray, R.; Otero, F.; Escardó, A.. "Sexuality in the age of AIDS". International Journal of Psycho-Analysis 79 1 (1998): 136-139. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031892299&partnerID=MN8TOARS.
  150. S. Anguiano-Igea; F.J. Otero-Espinar; J.L. Vila-Jato; J. Blanco-Méndez. "Interaction of clofibrate with cyclodextrin in solution: phase solubility, 1H NMR and molecular modelling studies". European Journal of Pharmaceutical Sciences 5 4 (1997): 215-221. https://doi.org/10.1016%2Fs0928-0987%2897%2900277-7.
    10.1016/s0928-0987(97)00277-7
  151. M.I. González Siso; E. Lang; B. Carrenõ-Gómez; M. Becerra; F. Otero Espinar; J. Blanco Méndez. "Enzyme encapsulation on chitosan microbeads". Process Biochemistry 32 3 (1997): 211-216. https://doi.org/10.1016%2Fs0032-9592%2896%2900064-7.
    10.1016/s0032-9592(96)00064-7
  152. Siso, M.I.G.; Lang, E.; Carrenõ-Gómez, B.; Becerra, M.; Otero Espinar, F.; Blanco Méndez, J.. "Enzyme encapsulation on chitosan microbeads". Process Biochemistry 32 3 (1997): 211-216. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030792370&partnerID=MN8TOARS.
    10.1016/S0032-9592(96)00064-7
  153. Anguiano-Igea, S; Otero-Espinar, FJ; Vila-Jato, JL; Blanco-Mendez, J. "Interaction of clofibrate with cyclodextrin in solution: phase solubility, H-1 NMR and molecular modelling studies". European Journal of Pharmaceutical Sciences 5 4 (1997): 215-221.
    10.1016/S0928-0987(97)00277-7
  154. M.J. Buján; S.M. Stober; S. Anguiano-Igea; F.J. Otero-Espinar; J. Blanco-Méndez. "Obtention of c0hitosan-acasia microcapsules by coacervation. Preliminary studies". European Journal of Pharmaceutical Sciences 4 (1996): S135-S135. https://doi.org/10.1016%2Fs0928-0987%2897%2986394-4.
    10.1016/s0928-0987(97)86394-4
  155. A. Rodriguez-Gómez; S. Anguiano-Igea; F.J. Otero-Espinar; J. Blanco-Méndez. "Effect of bioadhesive polymers on pellets obtained by extrusion/spheronization". European Journal of Pharmaceutical Sciences 4 (1996): S176-S176. https://doi.org/10.1016%2Fs0928-0987%2897%2986533-5.
    10.1016/s0928-0987(97)86533-5
  156. F.J. Otero-Espinar; A. Ganza-González; S. Anguiano-Igea; J. Blanco-Méndez. "Metoclopramide release from Chitosan microspheres". European Journal of Pharmaceutical Sciences 4 (1996): S133-S133. https://doi.org/10.1016%2Fs0928-0987%2897%2986387-7.
    10.1016/s0928-0987(97)86387-7
  157. BlancoFuente, H; VilaDorrio, B; AnguianoIgea, S; OteroEspinar, FJ; BlancoMendez, J. "Tanned leather: A good model for determining hydrogels bioadhesion". International Journal of Pharmaceutics 138 1 (1996): 103-112.
    10.1016/0378-5173(96)04542-5
  158. BlancoFuente, H; AnguianoIgea, S; OteroEspinar, FJ; BlancoMendez, J. "In-vitro bioadhesion of carbopol hydrogels". International Journal of Pharmaceutics 142 2 (1996): 169-174.
    10.1016/0378-5173(96)04665-0
  159. BlancoFuente, H; AnguianoIgea, S; OteroEspinar, FJ; BlancoMendez, J. "Kinetics of anhydride formation in xerogels of poly(acrylic acid)". Biomaterials 17 17 (1996): 1667-1675.
    10.1016/0142-9612(96)87646-0
  160. AnguianoIgea, S; OteroEspinar, FJ; VilaJato, JL; BlancoMendez, J. "Improvement of clofibrate dissolution by complexation with cyclodextrin". International Journal of Pharmaceutics 135 1-2 (1996): 161-166.
    10.1016/0378-5173(96)04477-8
  161. S. Anguiano-Igea; F.J. Otero-Espinar; J.L. Vila-Jato; J. Blanco-Méndez. "The properties of solid dispersions of clofibrate in polyethylene glycols". Pharmaceutica Acta Helvetiae 70 1 (1995): 57-66. https://doi.org/10.1016%2F0031-6865%2894%2900051-v.
    10.1016/0031-6865(94)00051-v
  162. Anguiano-Igea, S.; Otero-Espinar, F.J.; Vila-Jato, J.L.; Blanco-Méndez, J.. "The properties of solid dispersions of clofibrate in polyethylene glycols". Pharmaceutica Acta Helvetiae 70 1 (1995): 57-66. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028963035&partnerID=MN8TOARS.
    10.1016/0031-6865(94)00051-V
  163. GarcíGonzález, N.; Kellaway, I.W.; Blanco Fuente, H.; Anguiano Igea, S.; Delgado Charro, B.; Otero Espinar, F.J.; Blanco Méndez, J.. "Influence of glycerol concentration and carbopol molecular weight on swelling and drug release characteristics of metoclopramide hydrogels". International Journal of Pharmaceutics 104 2 (1994): 107-113. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028299080&partnerID=MN8TOARS.
    10.1016/0378-5173(94)90185-6
  164. GANZAGONZALEZ, A; VILAJATO, JL; ANGUIANOIGEA, S; OTEROESPINAR, FJ; BLANCOMENDEZ, J. "A PROTON NUCLEAR-MAGNETIC-RESONANCE STUDY OF THE INCLUSION COMPLEX OF NAPROXEN WITH BETA-CYCLODEXTRIN". International Journal of Pharmaceutics 106 3 (1994): 179-185.
    10.1016/0378-5173(94)90001-9
  165. Anguiano-Igea, S.; Otero-Espinar, F.J.; Vila-Jato, J.L.; Blanco-Mendez, J.. "Rheological properties of the complex clofibrate/ß-cyclodextrin". Proceedings of the Controlled Release Society 21 (1994): 728-729. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027973316&partnerID=MN8TOARS.
  166. Otero-Espinar, F.J.; Blanco-Fuente, H.; Vila-Dorrio, B.; Anguiano-Igea, S.; Ganza-Gonzalez, A.; Blanco-Mendez, J.. "Optimization of adhesion measurement by tensile tester". Proceedings of the Controlled Release Society 21 (1994): 700-701. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028075695&partnerID=MN8TOARS.
  167. Otero-Espinar, F.J.; Blanco-Fuente, H.; Vila-Dorrio, B.; Anguiano-Igea, S.; Ganza-Gonzalez, A.; Blanco-Mendez, J.. "Influence of substrate on adhesion test". Proceedings of the Controlled Release Society 21 (1994): 702-703. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027945360&partnerID=MN8TOARS.
  168. N. García-González; I.W. Kellaway; H. Blanco-Fuente; S. Anguiano-Igea; B. Delgado-Charro; F.J. Otero-Espinar; J. Blanco-Méndez. "Influence of ß-cyclodextrin concentration and polyacrylic acid molecular weight on swelling and release characteristics of metoclopramide-containing hydrogels". International Journal of Pharmaceutics 100 1-3 (1993): 25-31. https://doi.org/10.1016%2F0378-5173%2893%2990071-m.
    10.1016/0378-5173(93)90071-m
  169. N. García-González; I.W. Kellaway; H. Blanco-Fuente; S. Anguiano-Igea; B. Delgado-Charro; F.J. Otero-Espinar; J. Blanco-Méndez. "Design and evaluation of buccoadhesive metoclopramide hydrogels composed of poly(acrylic acid) crosslinked with sucrose". International Journal of Pharmaceutics 100 1-3 (1993): 65-70. https://doi.org/10.1016%2F0378-5173%2893%2990076-r.
    10.1016/0378-5173(93)90076-r
  170. GARCIAGONZALEZ, N; KELLAWAY, IW; BLANCOFUENTE, H; ANGUIANOIGEA, S; DELGADOCHARRO, B; OTEROESPINAR, FJ; BLANCOMENDEZ, J. "DESIGN AND EVALUATION OF BUCCOADHESIVE METOCLOPRAMIDE HYDROGELS COMPOSED OF POLY(ACRYLIC ACID) CROSS-LINKED WITH SUCROSE". International Journal of Pharmaceutics 100 1-3 (1993): 65-70.
    10.1016/0378-5173(93)90076-R
  171. GARCIAGONZALEZ, N; KELLAWAY, IW; BLANCOFUENTE, H; ANGUIANOIGEA, S; DELGADOCHARRO, B; OTEROESPINAR, FJ; BLANCOMENDEZ, J. "INFLUENCE OF BETA-CYCLODEXTRIN CONCENTRATION AND POLYACRYLIC-ACID MOLECULAR-WEIGHT ON SWELLING AND RELEASE CHARACTERISTICS OF METOCLOPRAMIDE-CONTAINING HYDROGELS". International Journal of Pharmaceutics 100 1-3 (1993): 25-31.
    10.1016/0378-5173(93)90071-M
  172. F.J. Otero-Espinar; S. Anguiano-Igea; N. García-González; J.L. Vila-Jato; J. Blanco-Méndez. "Interaction of naproxen with ß-cyclodextrin in solution and in the solid state". International Journal of Pharmaceutics 79 1-3 (1992): 149-157. https://doi.org/10.1016%2F0378-5173%2892%2990106-c.
    10.1016/0378-5173(92)90106-c
  173. Garcia-Gonzalez, N.; Blanco-Fuente; Anguiano-Igea, S.; Delgado-Charro, B.; Otero-Espinar, F.J.; Blanco-Mendez, J.. "In vitro characterization of bioadhesive metoclopramide tablets for buccal application prepared with polyacrylic acid and hydroxypropyl methylcellulose". S.T.P. Pharma Sciences 2 6 (1992): 494-499. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027052791&partnerID=MN8TOARS.
  174. Anguiano-Igea, S.; Otero Espinar, F.J.; Vila-Jato, J.L.; Blanco-Mendez, J.. "Evaluation of the sealed heating method for the obtention of a clofibrate/ß-cyclodextrin inclusion complex". S.T.P. Pharma Sciences 2 4 (1992): 325-331. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026730634&partnerID=MN8TOARS.
  175. OTEROESPINAR, FJ; ANGUIANOIGEA, S; GARCIAGONZALEZ, N; VILAJATO, JL; BLANCOMENDEZ, J. "INTERACTION OF NAPROXEN WITH BETA-CYCLODEXTRIN IN SOLUTION AND IN THE SOLID-STATE". International Journal of Pharmaceutics 79 2-3 (1992): 149-157.
    10.1016/0378-5173(92)90106-C
  176. F.J. Otero-Espinar; S. Anguiano-Igea; N. García-Gonzalez; J.L. Vila-Jato; J. Blanco-Méndez. "Oral bioavailability of naproxen-ß-cyclodextrin inclusion compound". International Journal of Pharmaceutics 75 1 (1991): 37-44. https://doi.org/10.1016%2F0378-5173%2891%2990248-m.
    10.1016/0378-5173(91)90248-m
  177. Garcia Gonzalez, N.; Anguiano Igea, S.; Otero Espinar, F.J.; Vila Jato, J.L.; Blanco Mendez, J.. "Bioadhesive systems as form of controlled releasing. Part II: Methods for the study of the bioadhesion,SISTEMAS BIOADHESIVOS COMO FORMAS DE LIBERACION CONTROLADA. PARTE II: METODOS DE ESTUDIO DE LA BIOADHESION". Farmacia Hospitalaria 15 5 (1991): 299-305. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025945199&partnerID=MN8TOARS.
  178. Vila Jato, J.L.; Blanco Mendez, J.; Anguiano Igea, S.; Otero Espinar, F.J.; Fernandez Souto, J.; Torres Lanbandeira, J.J.. "Inclusion compounds with cyclodextrin. Part I: Origin, properties and biopharmaceutical applications of the cyclodextrins". Farmacia Hospitalaria 15 1 (1991): 14-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025752317&partnerID=MN8TOARS.
  179. Blanco Fuente, H.; Anguiano Igea, S.; Garcia Gonzalez, N.; Delgado Charro, M.B.; Otero Espinar, F.J.; Blanco Mendez, J.. "The nasal route as an alternative for drug administration,LA VIA NASAL COMO ALTERNATIVA PARA LA ADMINISTRACION DE MEDICAMENTOS". Farmacia Clinica 8 10 (1991): 944-945+949. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026319701&partnerID=MN8TOARS.
  180. Torres-Labandeira, J.J.; Otero-Espinar, F.; Anguiano-Igea, S.; Glanco-Mendez, J.; Vila Jato, J.L.. "Influence of storage on the biopharmaceutical properties of the tobutamide/ß-cyclodextrin inclusion complex". S.T.P. Pharma Sciences 1 5 (1991): 326-330. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026341575&partnerID=MN8TOARS.
  181. Blanco Fuente, H.; Anguiano Igea, S.; Delgado Charro, M.B.; Garcia Gonzalez, N.; Otero Espinar, F.J.; Blanco Mendez, J.. "Bioadhesive systems for buccal application,SISTEMAS BIOADHESIVOS PARA APLICACION BUCAL". Farmacia Clinica 8 9 (1991): 843-856. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026376803&partnerID=MN8TOARS.
  182. Garcia Gonzalez, N.; Anguiano Igea, S.; Otero Espinar, F.J.; Vila Jato, J.L.; Blanco Mendez, J.. "Bioadhesive systems as a form of controlled release. III. Main applications of bioadhesive formulas,SISTEMAS BIOADHESIVOS COMO FORMAS DE LIBERACION CONTROLADA. PARTE III. PRINCIPALES APLICACIONES DE LAS FORMULACIONES BIOADHESIVAS". Farmacia Hospitalaria 15 6 (1991): 371-377. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026319470&partnerID=MN8TOARS.
  183. Garcia Gonzalez, N.; Anguiano Igea, S.; Otero Espinar, F.J.; Vila Jato, J.L.; Blanco Mendez, J.. "Bioadhesive systems for controlled drug release. I: Basic aspects of bioadhesion,SISTEMAS BIOADHESIVOS COMO FORMAS DE LIBERACION CONTROLADA. PARTE I: ASPECTOS FUNDAMENTALES DE LA BIOADHESION". Farmacia Hospitalaria 15 4 (1991): 187-194. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025874023&partnerID=MN8TOARS.
  184. OTEROESPINAR, FJ; ANGUIANOIGEA, S; GARCIAGONZALEZ, N; VILAJATO, JL; BLANCOMENDEZ, J. "ORAL BIOAVAILABILITY OF NAPROXEN-BETA-CYCLODEXTRIN INCLUSION COMPOUND". International Journal of Pharmaceutics 75 1 (1991): 37-44.
    10.1016/0378-5173(91)90248-M
  185. BLANCO, J; VILAJATO, JL; OTERO, F; ANGUIANO, S. "INFLUENCE OF METHOD OF PREPARATION ON INCLUSION COMPLEXES OF NAPROXEN WITH DIFFERENT CYCLODEXTRINS". Drug Development and Industrial Pharmacy 17 7 (1991): 943-957.
    10.3109/03639049109040831
  186. Espinar, F.J.O.; Igea, S.A.; Méndez, J.B.; Jato, J.L.V.. "Reduction in the ulcerogenicity of naproxen by complexation with ß-cyclodextrin". International Journal of Pharmaceutics 70 1-2 (1991): 35-41. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025732982&partnerID=MN8TOARS.
    10.1016/0378-5173(91)90161-G
  187. Vila Jato, J.L.; Blanco Mendez, J.; Anguiano Igea, S.; Otero Espinar, F.J.; Fernandez Souto, J.; Torres Lavandeira, J.J.. "Inclusion compounds with cyclodextrin. Part III: Biopharmaceutical study,COMPUESTOS DE INCLUSION CON CICLODEXTRINAS. PARTE III: ESTUDIOS BIOFARMACEUTICOS". Farmacia Hospitalaria 14 3 (1990): 115-120. http://www.scopus.com/inward/record.url?eid=2-s2.0-0025026978&partnerID=MN8TOARS.
  188. Vila Jato, J.L.; Blanco Mendez, J.; Anguiano Igea, S.; Otero Es inar, F.J.; Fernandez Souto, J.; Torres Labandeira, J.J.. "Inclusion compounds with cyclodextrins. Part II: Preparation and methods of study,COMPUESTOS DE INCLUSION CON CICLODEXTRINAS. PARTE II: PREPARACION Y METODOS DE ESTUDIO". Farmacia Hospitalaria 14 1 (1990): 35-42. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024986412&partnerID=MN8TOARS.
Capítulo de livro
  1. Seoane-Viaño, I.; Otero-Espinar, F.J.; Goyanes, Á.. "3D printing of pharmaceutical products". 569-597. 2021.
  2. Díaz-Tome, V.; Ares, M.T.-R.; Varela-Fernández, R.; Touriño-Peralba, R.; González-Barcia, M.; Martínez-Pérez, L.; Lamas, M.J.; Otero-Espinar, F.J.; Fernández-Ferreiro, A.. "Therapeutic approach in fungal keratitis". 189-216. 2019.
Livro
  1. Otero-Espinar, F.J.; Fernández-Ferreiro, A.; González-Barcia, M.; Blanco-Méndez, J.; Luzardo, A.. Stimuli sensitive ocular drug delivery systems. 2018.
Pré-impressão
  1. J. Victor Alvarez; Susana B Bravo; Maria del Pilar Chantada-Vázquez; Carmen Pena; Cristóbal Colón; Shunji Tomatsu; Francisco J. Otero-Espinar; MARIA LUZ COUCE. "Morquio a Syndrome: Identification of Differential Patterns of Molecular Pathway Interac-Tions in Bone Lesions". 2024. https://doi.org/10.20944/preprints202401.2246.v1.
    10.20944/preprints202401.2246.v1

Outros

Outra produção
  1. Stimuli sensitive ocular drug delivery systems. 2018. Francisco J. Otero-Espinar; Anxo Fernández-Ferreiro; Miguel González-Barcia; José Blanco-Méndez; Asteria Luzardo. https://doi.org/10.1016%2Fb978-0-12-813689-8.00006-9.
    10.1016/b978-0-12-813689-8.00006-9
  2. Preparation by Extrusion/Spheronization of Triamcinolone / ß-Cyclodextrin Pellets as a Fast Release Dosage Form. 1999. M. E. Villar-López; F. Otero-Espinar; J. Blanco-Méndez. https://doi.org/10.1007%2F978-94-011-4681-4_115.
    10.1007/978-94-011-4681-4_115
  3. Study of Inclusion Compound of Triamcinolone Acetonide. 1999. M. E. Villar-López; L. Nieto-Reyes; F. Otero-Espinar; J. Blanco-Méndez. https://doi.org/10.1007%2F978-94-011-4681-4_99.
    10.1007/978-94-011-4681-4_99
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2025 - 2025 Tratamiento Oral para la enfermedad de Hunter
Orientador
Universidade de Santiago de Compostela, Espanha
2024 - 2025 Desenvolvemento de sistemas terapéuticos avanzados para o tratamento de enfermidades oculares inflamatorias e dexenerativas.
Orientador de Selene Cuello Rodríguez
Universidade de Santiago de Compostela, Espanha
2024 - 2025 Multifunctional Stimuli-Responsive Nanomedicine for Combined Therapy for Amyotrophic Lateral Sclerosis
Coorientador
Universidade do Porto, Portugal
2024 - 2025 Desenvolvimento e avaliação de medicamentos tópicos ungueais para tratamento de onicomicoses a base de amorolfina
Coorientador
Universidade Federal de Pernambuco, Brasil
2024 - 2025 Formulações secas para o tratamento de candidíase mamária
Coorientador
Universidade de Brasília, Brasil
2023 - 2025 ROS-sensitive nanoparticles as carriers for Edaravone delivery: an innovative strategy in Amyotrophy Lateral Sclerosis treatment
Coorientador de Brandon Lage Aguiar
Universidade do Porto, Portugal
2022 - 2025 SISTEMAS LIPÍDICOS IMPLANTABLES PARA LIBERACIÓN CONTROLADA DE BEVACIZUMAB EN EL SEGMENTO POSTERIOR DEL OJO
Orientador
Universidade de Santiago de Compostela, Espanha
2022 - 2025 TERAGNOSIS EN ENFERMIDADES INFLAMATORIAS MEDIANTE IMAXE PET CON 89ZR-ANTI-TNF
Coorientador
Universidade de Santiago de Compostela, Espanha
2022 - 2025 Desenvolvemento de formulacións tópicas para o tratamento de patoloxías da pel e da unlla.
Orientador
Universidade de Santiago de Compostela, Espanha
2021 - 2025 Using a nanomedicine-based approach as a second chance for tolcapone
Coorientador
2018 - 2025 Farmacocinética e farmacoxenética de ranibizumab na Dexeneración Macular Asociada a Idade
Coorientador
Universidade de Santiago de Compostela, Espanha
2024 - 2024 Proxecto NIPE-TDM: Avaliación da concentración-resposta da inmunoterapia en pacientes oncolóxicos: experiencia clínica real.
Orientador
Universidade de Santiago de Compostela, Espanha
2021 - 2024 Evaluation of fluid bed technology for the preparation of solid dispersions intended for immediate drug release systems
Orientador
Universidade de Santiago de Compostela, Espanha
2021 - 2024 New strategies for the prevention and treatment of complications associated with diabetes mellitus
Orientador
Universidade de Santiago de Compostela, Espanha
2021 - 2024 Formulación Magistral y Digitalización: dos herramientas clave de la Farmacia Hospitalaria para la Innovación en Salud
Coorientador de Iria Varela Rey
Universidade de Santiago de Compostela, Espanha
2011 - 2024 Hidrogeles biodegradables de polisacáridos para la liberación colónica de fármacos
Orientador de Manuel Gago Guillan
Universidade de Santiago de Compostela, Espanha
2019 - 2023 Development of topical ophthalmic formulations for fungal keratitis treatment
Orientador
Universidade de Santiago de Compostela, Espanha
2019 - 2023 Pharmaceutical compounding and drug repositioning from hospital pharmacy in situations of therapeutic gap
Coorientador
Universidade de Santiago de Compostela, Espanha
2019 - 2022 Therapeutic alternatives research for the treatment of ocular inflammatory diseases
Coorientador de Xurxo García Otero
Universidade de Santiago de Compostela, Espanha
2019 - 2022 Research and development of advanced controlled drug delivery systems: application in Keratoconus and Leber´s Hereditary Optic Neuropathy
Orientador de Ruben Varela Fernández
Universidade de Santiago de Compostela, Espanha
2017 - 2020 Improvement of anterior and posterior segment ocular drug delivery: application in ocular cystinosis and age-related macular degeneration
Orientador de Andrea Luaces Rodríguez
Universidade de Santiago de Compostela, Espanha
2017 - 2020 Novel approaches in local drug delivery systems for the treatment of Inflammatory Bowel Disease
Orientador
Universidade de Santiago de Compostela, Espanha
2016 - 2019 Optimización farmacoeconómica de la prestación farmacéutica en pacientes institucionalizados
Orientador de Xavier Martinez Casal
Universidade de Santiago de Compostela, Espanha
2016 - 2018 Sistemas lipídicos nanoestructurados: conteniendo elosulfasa alfa para el tratamiento de la enfermedad de morquio a
Orientador de José Victor Álvarez González
Universidade de Santiago de Compostela, Espanha
2015 - 2018 Lacas para el tratamiento de onicocmicosis y psoriasis ungueal
Orientador
Universidade de Santiago de Compostela, Espanha
2013 - 2016 La gestión de la oficina de farmacia: factores a considerar
Coorientador
Universidade de Santiago de Compostela, Espanha
2013 - 2016 Diseño de lentes de contacto blandas para la liberación controlada de acetónido de triamcinolona en la superficie ocular
Orientador
Universidade de Santiago de Compostela, Espanha
2012 - 2015 Manejo, seguridad y optimización de formulaciones tópicas oftálmicas en servicios de farmacia hospitalaria
Orientador
Universidade de Santiago de Compostela, Espanha
2011 - 2015 Desarrollo de emulsiones vaginales bioadhesivas resistentes al aclaramiento producido por los fluídos vaginales
Orientador
Universidade de Santiago de Compostela, Espanha
2009 - 2012 Hidrogeles termosensibles de polipseudorrotaxanos de ciclodextrinas-poloxámero como sistemas de liberación de fármacos a través de la lámina ungueal
Orientador de Luis Nogueiras Nieto
Universidade de Santiago de Compostela, Espanha
2003 - 2005 Peletización de diferentes mezclas de almidones y sus derivadoscaracterización mediante técnicas de análisis de imagen
Orientador de Sergio Almeida Prieto
Universidade de Santiago de Compostela, Espanha
1998 - 2003 Incorporación de sustancias bioactivas en sistemas microparticulares: aplicación en acuicultura
Coorientador de María Jesus Buján López
Universidade de Santiago de Compostela, Espanha
1997 - 2001 Preformulación del nuevo agente antimicrobiano 1-(5-bromofur-2-il)-2-bromo-2-nitroeteno
Orientador de Mirtha Mayra González Bedía
Universidade de Santiago de Compostela, Espanha
1995/07/01 - 1999/10/01 Evaluacion de pelts recubiertos de etilcelulosa/pectinas como sistemas de liberacion colonica de triamcinolona
Orientador
Universidade de Santiago de Compostela, Espanha
1995 - 1999 Utilización de los complejos de inclusión con ciclodextrinas para mejorar la eficacia de algunos agentes antiparasitarios
Orientador
Universidade de Santiago de Compostela, Espanha
1991/07/01 - 1995/09/01 Formulación y caracterización de hidrogeles bucoadhesivos para administración de principios activos de acción sistémica
Orientador
Universidade de Santiago de Compostela, Espanha
1995/06/01 - 1995/07/01 Mucoadhesión y biodisponibilidad de formulaciones de metoclopramida elaboradas a partir de polímeros bioadhesivos
Orientador de Alvaro Ganza González
Universidade de Santiago de Compostela, Espanha
1990/07/01 - 1993/07/01 Diseño y evaluación de formas farmacéuticas bioadhesivas para la administración bucal de principios activos de acción sistémica
Orientador de Nuria García González
Universidade de Santiago de Compostela, Espanha