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Identificação

Identificação pessoal

Nome completo
Gustavo Tiscornia

Nomes de citação

  • Tiscornia, Gustavo

Identificadores de autor

Ciência ID
7818-59E3-E4EE
ORCID iD
0000-0002-1841-5330

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Português Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Formação
Grau Classificação
2001
Concluído
 PhD in Genetics (Doutoramento)
University of Wisconsin-Madison, Estados Unidos
"Identification and Analysis of RNA Binding Proteins interacting with the Myotonic Dystrophy Protein Kinase 3’ untranslated region mRNA" (TESE/DISSERTAÇÃO)
 Awarded
1989
Concluído
 Ciencias Biologicas (Licenciatura)
Universidad de Buenos Aires, Argentina
"Isolation of PHB- mutants in Bacillus megaterium" (TESE/DISSERTAÇÃO)
 7.8/10
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2016/04/01 - Atual Investigador Coordenador (carreira) (Investigação) Clínica Eugin, Espanha
R&D Department, Clinica Eugin, Espanha
2011/09/01 - Atual Investigador principal (carreira) (Investigação) Universidade do Algarve, Portugal
1990/08/01 - 1991/12/31 Assistente de Investigação (carreira) (Investigação) Foundation for Applied Biological Science, Argentina

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2011/09/01 - 2016/03/31 Professor Auxiliar (Docente Universitário) Universidade do Algarve Centro de Investigação em Biomedicina, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2007/04/01 - 2011/08/26 Investigador Ramon y Cajal Centre de Medicina Regenerativa de Barcelona, Espanha
2001/12/03 - 2006/08/31 Postdoctoral Researcher Salk Institute for Biological Studies, Estados Unidos
1995/09/18 - 2001/08/16 PhD Candidate University of Wisconsin-Madison, Estados Unidos
1992/02/03 - 1995/07/31 Instructor of General Biology St. George's College North, Argentina
Projetos

Bolsa

Designação Financiadores
2020/01 - Atual SPINY: Identifying and Modulating the Mechanisms Responsible for Functional Recovery and Axon Regeneration of the Injured Acomys Spinal Cord.
MC-39-2019
Investigador
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Santa Casa da Misericórdia de Lisboa
Em curso
2016/04/01 - 2020/10/31 Regeneration in the African Spiny Mouse.
PTDC/BIA-ANM/0697/2014
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2014 - 2017/12/31 Integrative studies on the role of Ccbe1 in cardiogenesis: from the embryo to scalable multipronged generation of hESC-derived myocardial cells for heart tissue repair
HMSP-ICT/0039/2013
Bolseiro de Cientista Convidado
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Concluído
2012/01/01 - 2016/12/31 In Vitro Derivation of Beta Cells by Ectopic Expression of Pancreatic Transcription Factors
FP7-PEOPLE-2011-CIG (# FP7-304225
Bolseiro de Integração na Investigação
Universidade do Algarve Centro de Investigação em Biomedicina, Portugal
Concluído
2009/01/01 - 2012/12/31 Creación de una plataforma nacional para la derivación y manipulación de células iPS en condiciones GMP con fines terapéuticos
PLE2009-0164
Investigador
Centre de Medicina Regenerativa de Barcelona, Espanha
Concluído
2006/01/01 - 2012/12/31 Red de Terapia Celular (TerCel)
RD06/0010/0016
Investigador
Centre de Medicina Regenerativa de Barcelona, Espanha

Projeto

Designação Financiadores
2020/10/01 - 2024/09/30 Skin Tissue Engineering and Regenerative Medicine: From skin repair to regeneration (SKINTERM)
955722
Investigador responsável
Em curso
2013/01/01 - 2015/12/31 Genzyme Young Investigator Award: Development of an iPSc model for Gaucher’s Disease Type II.
Genzyme Young Investigator Award
Investigador responsável
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
Concluído
2004/01/01 - 2005/12/31 Lentiviral Delivery of siRNA against huntingtin
Hereditary Disease Foundation
Bolseiro de Pós-Doutoramento
Salk Institute for Biological Studies, Estados Unidos
Concluído
Produções

Publicações

Artigo em revista
  1. Nogueira-Rodrigues, Joana; Leite, Sérgio C.; Pinto-Costa, Rita; Sousa, Sara C.; Luz, Liliana L.; Sintra, Maria A.; Oliveira, Raquel; et al. "Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection". Developmental Cell 57 4 (2022): 440-450.e7. http://dx.doi.org/10.1016/j.devcel.2021.12.008.
    10.1016/j.devcel.2021.12.008
  2. Vergaro, Paula; Tiscornia, Gustavo; Zambelli, Filippo; Rodríguez, Amelia; Santaló, Josep; Vassena, Rita. "Trophoblast attachment to the endometrial epithelium elicits compartment-specific transcriptional waves in an in-vitro model". Reproductive BioMedicine Online 42 1 (2021): 26-38. http://dx.doi.org/10.1016/j.rbmo.2020.08.037.
    10.1016/j.rbmo.2020.08.037
  3. Vergaro, Paula; Tiscornia, Gustavo; Barragán, Montserrat; García, Désirée; Rodriguez, Amelia; Santaló, Josep; Vassena, Rita. "Vaginal microbiota profile at the time of embryo transfer does not affect live birth rate in IVF cycles with donated oocytes". Reproductive BioMedicine Online 38 6 (2019): 883-891. http://dx.doi.org/10.1016/j.rbmo.2018.12.019.
    10.1016/j.rbmo.2018.12.019
  4. Vergaro, Paula; Tiscornia, Gustavo; Rodríguez, Amelia; Santaló, Josep; Vassena, Rita. "Transcriptomic analysis of the interaction of choriocarcinoma spheroids with receptive vs. non-receptive endometrial epithelium cell lines: an in vitro model for human implantation". Journal of Assisted Reproduction and Genetics 36 5 (2019): 857-873. http://dx.doi.org/10.1007/s10815-019-01442-9.
    10.1007/s10815-019-01442-9
  5. Pinheiro, Gonçalo; Prata, Diogo Filipe; Araújo, Inês Maria; Tiscornia, Gustavo. "The African spiny mouse (Acomysspp.) as an emerging model for development and regeneration". Laboratory Animals 52 6 (2018): 565-576. http://dx.doi.org/10.1177/0023677218769921.
    10.1177/0023677218769921
  6. Santos, Dino; Tiscornia, Gustavo. "Induced Pluripotent Stem Cell Modeling of Gaucher’s Disease: What Have We Learned?". International Journal of Molecular Sciences 18 4 (2017): 888. http://dx.doi.org/10.3390/ijms18040888.
    10.3390/ijms18040888
  7. de la Mata, Mario; Cotán, David; Oropesa-Ávila, Manuel; Villanueva-Paz, Marina; de Lavera, Isabel; Álvarez-Córdoba, Mónica; Luzón-Hidalgo, Raquel; et al. "Coenzyme Q10 partially restores pathological alterations in a macrophage model of Gaucher disease". Orphanet Journal of Rare Diseases 12 1 (2017): http://dx.doi.org/10.1186/s13023-017-0574-8.
    10.1186/s13023-017-0574-8
  8. de la Mata, Mario; Cotán, David; Villanueva-Paz, Marina; de Lavera, Isabel; Álvarez-Córdoba, Mónica; Luzón-Hidalgo, Raquel; Suárez-Rivero, Juan; Tiscornia, Gustavo; Oropesa-Ávila, Manuel. "Mitochondrial Dysfunction in Lysosomal Storage Disorders". Diseases 4 4 (2016): 31. http://dx.doi.org/10.3390/diseases4040031.
    10.3390/diseases4040031
  9. Matias Santos, Dino; Rita, Ana Martins; Casanellas, Ignasi; Brito Ova, Adélia; Araújo, Inês Maria; Power, Deborah; Tiscornia, Gustavo. "Ear wound regeneration in the African spiny mouseAcomys cahirinus". Regeneration 3 1 (2016): 52-61. http://dx.doi.org/10.1002/reg2.50.
    10.1002/reg2.50
  10. Mena-Barragán, Teresa; Narita, Aya; Matias, Dino; Tiscornia, Gustavo; Nanba, Eiji; Ohno, Kousaku; Suzuki, Yoshiyuki; et al. "pH-Responsive Pharmacological Chaperones for Rescuing Mutant Glycosidases". Angewandte Chemie International Edition 54 40 (2015): 11696-11700. http://dx.doi.org/10.1002/anie.201505147.
    10.1002/anie.201505147
  11. Tiscornia, G.; Lorenzo Vivas, E.; Matalonga, L.; Berniakovich, I.; Barragán Monasterio, M.; Eguizábal, C.; Gort, L.; et al. "Neuronopathic Gaucher's disease: Induced pluripotent stem cells for disease modelling and testing chaperone activity of small compounds". Human Molecular Genetics 22 4 (2013): 633-645. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873040393&partnerID=MN8TOARS.
    10.1093/hmg/dds471
  12. Tiscornia, G.; Monserrat, N.; Belmonte, J.C.I.. "Modelling long QT syndrome with iPS cells: Be still, my beating heart .". Circulation Research 108 6 (2011): 648-649. http://www.scopus.com/inward/record.url?eid=2-s2.0-79953061450&partnerID=MN8TOARS.
    10.1161/RES.0b013e318216f0db
  13. Tiscornia, G.; Vivas, E.L.; Belmonte, J.C.I.. "Diseases in a dish: Modeling human genetic disorders using induced pluripotent cells". Nature Medicine 17 12 (2011): 1570-1576. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856112882&partnerID=MN8TOARS.
    10.1038/nm.2504
  14. Tiscornia, G.; Izpisúa Belmonte, J.C.. "MicroRNAs in embryonic stem cell function and fate". Genes and Development 24 24 (2010): 2732-2741. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650223089&partnerID=MN8TOARS.
    10.1101/gad.1982910
  15. Gonzalez, F.; Monasterio, M.B.; Tiscornia, G.; Pulido, N.M.; Vassena, R.; Morera, L.B.; Piza, I.R.; Belmonte, J.C.I.. "Generation of mouse-induced pluripotent stem cells by transient expression of a single nonviral polycistronic vector". Proceedings of the National Academy of Sciences of the United States of America 106 22 (2009): 8918-8922. http://www.scopus.com/inward/record.url?eid=2-s2.0-67049155513&partnerID=MN8TOARS.
    10.1073/pnas.0901471106
  16. Raya, A.; Rodríguez-Piz, I.; Guenechea, G.; Vassena, R.; Navarro, S.; Barrero, M.J.; Consiglio, A.; et al. "Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells". Nature 460 7251 (2009): 53-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650095306&partnerID=MN8TOARS.
    10.1038/nature08129
  17. Tiscornia, G.; Singer, O.; Verma, I.M.. "Design and cloning of an shRNA into a lentiviral silencing vector: Version A". Cold Spring Harbor Protocols 3 8 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-79954586070&partnerID=MN8TOARS.
    10.1101/pdb.prot5009
  18. Aasen, T.; Raya, A.; Barrero, M.J.; Garreta, E.; Consiglio, A.; Gonzalez, F.; Vassena, R.; et al. "Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes". Nature Biotechnology 26 11 (2008): 1276-1284. http://www.scopus.com/inward/record.url?eid=2-s2.0-55749089875&partnerID=MN8TOARS.
    10.1038/nbt.1503
  19. Tiscornia, G.; Singer, O.; Verma, I.M.. "Design and cloning of an shRNA into a lentiviral silencing vector: Version B". Cold Spring Harbor Protocols 3 8 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-79954623559&partnerID=MN8TOARS.
    10.1101/pdb.prot5010
  20. Singer, O.; Tiscornia, G.; Ikawa, M.; Verma, I.M.. "Rapid generation of knockdown transgenic mice by silencing lentiviral vectors". Nature Protocols 1 1 (2006): 286-292. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250662301&partnerID=MN8TOARS.
    10.1038/nprot.2006.44
  21. Tiscornia, G.; Singer, O.; Verma, I.M.. "Design and cloning of lentiviral vectors expressing small interfering RNAs". Nature Protocols 1 1 (2006): 234-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250664283&partnerID=MN8TOARS.
    10.1038/nprot.2006.36
  22. Tiscornia, G.; Singer, O.; Verma, I.M.. "Production and purification of lentiviral vectors". Nature Protocols 1 1 (2006): 241-245. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250666701&partnerID=MN8TOARS.
    10.1038/nprot.2006.37
  23. Tiscornia, G.; Tergaonkar, V.; Galimi, F.; Verma, I.M.. "CRE recombinase-inducible RNA interference mediated by lentiviral vectors". Proceedings of the National Academy of Sciences of the United States of America 101 19 (2004): 7347-7351. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442584612&partnerID=MN8TOARS.
    10.1073/pnas.0402107101
  24. Tiscornia, G.; Singer, O.; Ikawa, M.; Verma, I.M.. "A general method for gene knockdown in mice by using lentiviral vectors expressing small interfering RNA". Proceedings of the National Academy of Sciences of the United States of America 100 4 (2003): 1844-1848. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037452812&partnerID=MN8TOARS.
    10.1073/pnas.0437912100
  25. Phan, D.; Han, E.; Birrell, G.; Bonnal, S.; Duggan, L.; Esumi, N.; Gutstein, H.; et al. "Purification and characterization of human cell-cell adhesion molecule 1 (C-CAM1) expressed in insect cells". Protein Expression and Purification 21 2 (2001): 343-351. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035714994&partnerID=MN8TOARS.
    10.1006/prep.2000.1382
  26. Tiscornia, G.; Mahadevan, M.S.. "Myotonic dystrophy: The role of the CUG triplet repeats in splicing of a novel DMPK exon and altered cytoplasmic DMPK mRNA isoform ratios". Molecular Cell 5 6 (2000): 959-967. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033638394&partnerID=MN8TOARS.
Capítulo de livro
  1. Tiscornia, Gustavo; Lorenzo Vivas, E.; Izpisua Belmonte, J.C.. "MicroRNA regulation of Stem Cell fate and Reprogramming". In MicroRNAs in Medicine, 27-40. Hoboken, New Jersey, Estados Unidos: John Wiley & sons, 2013.
    Publicado
  2. Singer, O.; Tiscornia, Gustavo; Verma, I.M.. "Knockdown transgenic mice generated by Silencing Lentiviral Vectors". In Gene Transfer: Delivery and Expression of DNA and RNA, 755-759. Estados Unidos: Cold Spring Harbor Laboratory Press., 2005.
    Publicado
  3. Tiscornia, Gustavo; Singer, O.; Verma, I.M.. "Development of Lentiviral Vectors Expressing siRNA". In Gene Transfer: Delivery and Expression of DNA and RNA, 23-34. Estados Unidos: Cold Spring Harbor Laboratory Press., 2005.
    Publicado
  4. Singer, O.; Tiscornia, Gustavo; Verma, I.M.. "siRNA delivery by Lentiviral Vectors: Design and Applications". In RNA Interference Technology. Cambridge, Reino Unido: Cambridge University Press, 2004.
    Publicado
Distinções

Prémio

2016 Contrato Torres Quevedo
Gobierno de España Ministerio de Ciencia e Innovación, Espanha

Outra distinção

2012 Genzyme Young Investigator Award
Genzyme Corporation, Estados Unidos
2006 Ramon y Cajal Fellowship
2005 Kirchstein National Research Service Award