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Ricardo G. Teixeira completed his university studies at the University of Lisbon, where he obtained his MSc (Faculty of Sciences of University of Lisbon) and PhD (University of Lisbon) degrees working with organometallic compounds. His Master’s thesis was focused on the development of ruthenium-based compounds as prospective anticancer agents and was supervised by Professor Andreia Valente and Professor Clara Viñas. During his Master’s, he also had the opportunity to enrich his professional (and cultural) experience during a short-term scientific mission at the Prof. Clara Viñas' Group at the Institute of Materials Science of Barcelona (ICMAB-CSIC, Spain) where he worked on the synthesis and characterization of new Ru-carboranyl complexes as potential anticancer bimodal agents. In May 2024, he completed his PhD in Chemistry (specialty in Inorganic Chemistry; summa cum laude) under the supervision of Professor Andreia Valente and Professor Ana Isabel Tomaz. During his PhD work, he developed new organometallic Ru(II)-based metallodrugs with fluorescent properties to tackle multidrug resistant cancers. In 2022 he was a visiting student at the Department of Inorganic and Analytical Chemistry (University of Szeged, Hungary) under the supervision of Professor Éva Ana Enyedy, performing biospeciation studies and gaining skills in spectroscopic tools to study interactions of metallodrugs with endogen bioligands. Ricardo G. Teixeira is currently a postdoctoral fellow at Instituto Superior Técnico working on synthesis of cocrystals using mechanochemistry under the supervision of Doctor Vânia André and Doctor Clara Gomes. He co-authors a total of 13 publications (>160 citations, Scopus) in peer-reviewed international journals and has an h-index of 7 (Scopus). Among them, 3 papers rank in the Top 5% of the field and 2 in the Top 10%; 2 of them have been featured on the front cover of the top Medicinal Chemistry Journal (Journal of Medicinal Chemistry), and another was prized as a HOT Topic and featured on the inside cover of Inorganic Chemistry Frontiers. He also co-authors 1 book chapter of international circulation. His work has been presented in 9 oral presentations so far and over 21 poster communications.
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Identificação

Identificação pessoal

Nome completo
Ricardo Jorge Gonçalves Teixeira
Data de nascimento
1992/11/07
Género
Masculino

Nomes de citação

  • Ricardo G. Teixeira

Identificadores de autor

Ciência ID
8119-2DA0-7EC3
ORCID iD
0000-0002-1028-0486
Google Scholar ID
https://scholar.google.com/citations?user=oi1FFn4AAAAJ&hl=en
Researcher Id
L-7014-2017
Scopus Author Id
57198448169

Endereços de correio eletrónico

  • rjteixeira@fc.ul.pt (Profissional)
  • fc40672@alunos.fc.ul.pt (Profissional)

Moradas

  • Faculdade de Ciências da Universidade de Lisboa . Centro de Química Estrutural – Ciências; Faculdade de Ciências da Universidade de Lisboa Edifício C8, Lab. 8.5.46, 1749-016, Campo Grande , Lisboa, Portugal (Profissional)

Domínios de atuação

  • Ciências Exatas - Química - Química Inorgânica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2)
Formação
Grau Classificação
2024/05/24
Concluído
 PhD in Chemistry (Doutoramento)
Especialização em Inorganic Chemistry
Universidade de Lisboa Faculdade de Ciências, Portugal
"Targeting cancer with ruthenium compounds " (TESE/DISSERTAÇÃO)
 Full score (summa cum laude)
2017
Concluído
 MSc in Chemistry (Mestrado)
Especialização em Chemistry
Universidade de Lisboa Faculdade de Ciências, Portugal
"Synthesis of new 3D-eta5-carboranyl and eta5-methylcyclopentadienyl ruthenium complexes incorporating bipyridine (macro)ligands as promising anticancer agents" (TESE/DISSERTAÇÃO)
 18 points (out of 20)
2014
Concluído
 BSc in Chemistry (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Desenvolvimento de potenciais metalofármacos para a terapia do cancro (PT) | Development of potential metallodrugs for cancer therapy (EN)" (TESE/DISSERTAÇÃO)
 15 points (out of 20)
Percurso profissional

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2024/04/01 - 2024/08/31 Grantee within Arrows2Cancer project (PTDC/QUI-QIN/0146/2020) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2019/01 - 2023/05/31 Research work in the frame of Ph.D. thesis "Targeting cancer with ruthenium compounds" Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa Centro de Química Estrutural, Portugal
2021 - 2021 Short Term Scientific Mission "Biospeciation studies of `Ru-cyclopentyadienyl´ anti-tumor agents" - Scientific and Technological Cooperation Project Portugal-Hungary FCT/NKFIH, 2019/20 Universidade de Lisboa Faculdade de Ciências, Portugal
Szegedi Tudományegyetem Kémiai Intézet, Hungria
2017/12/01 - 2018/12/19 Grantee within RuCA project (IF/01179/2013) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa Faculdade de Ciências, Portugal
2016/09/01 - 2017/07/25 Research work in the frame of M.Sc. thesis "Synthesis of new 3D-eta5-carboranyl and eta5-methylcyclopentadienyl ruthenium complexes incorporating bipyridine (macro)ligands as promising anticancer ag Universidade de Lisboa Faculdade de Ciências, Portugal
2017/03 - 2017/04 Short Term Scientific Mission "Characterization of new 3D-eta5-carboranyl derivatives ruthenium complexes incorporating polymeric ligands towards combinatory therapy in cancer" - COST Grantee Institut de Ciència de Materials de Barcelona, Espanha
Institut de Ciència de Materials de Barcelona, Espanha
2013/09/01 - 2014/06/19 Research work in the frame of B.Sc. final project "Development of new metallodrugs for cancer therapy" Universidade de Lisboa Faculdade de Ciências, Portugal
Projetos

Bolsa

Designação Financiadores
2024/04/01 - 2024/08/31 Ruthenium-peptide conjugates: arrows for selectively targeting breast cancer
PTDC/QUI-QIN/28662/2017
Bolseiro de Investigação
Universidade de Lisboa Centro de Química Estrutural, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019/06/01 - 2022/12/31 FCT NKFIH 2019/2020 - Development and biospeciation studies of antitumor ruthenium complexes
FCT/NKFIH_2019/2020
Bolseiro de Investigação
Universidade de Lisboa Faculdade de Ciências, Portugal

Szegedi Tudományegyetem, Hungria
Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2018/09/01 - 2022/04/30 Fighting metastatic cancers: prime time for ruthenium
PTDC/QUI-QIN/28662/2017
Bolseiro de Investigação
Universidade do Minho, Portugal

FCiênciasID Associação para a Investigação e Desenvolvimento de Ciências, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2017/12/01 - 2018/12/20 Developing the potential of ruthenium complexes in cancer chemotherapy - RuCA
IF/01179/2013/CP1159/CT0002
Bolseiro de Investigação
Universidade de Lisboa Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. R. G. Teixeira, A. Stefanelli, A. Pilon, R. Warmers, X. Fontrodona, I. Romero, P. J. Costa, M. J. V. Brito, X. Hudec,. "Paraptotic Cell Death as an Unprecedented Mode of Action Observed for New Bipyridine-Silver(I) Compounds Bearing Phosphane Coligands". Journal of Medicinal Chemistry (2024): http://dx.doi.org/10.1021/acs.jmedchem.3c01036.
    10.1021/acs.jmedchem.3c01036
  2. I. Maximiano, C. Henriques, R. G. Teixeira, F. Marques, A. Valente, A. M. M. Antunes. "Lead to hit ruthenium-cyclopentadienyl anticancer compounds: Cytotoxicity against breast cancer cells, metabolic stability and metabolite profiling". Journal of Inorganic Biochemistry (2024): http://dx.doi.org/10.1016/j.jinorgbio.2023.112436.
    10.1016/j.jinorgbio.2023.112436
  3. I. C. Salaroglio, D. Stefanova, R. G. Teixeira, N. F. B. Oliveira, A. Ahmed, F. Fusi, V. Tzankova, Y. Yordanov, M. Machu. "A novel combinatory treatment against a CDDP-resistant non-small cell lung cancer based on a ruthenium(II) cyclopentadienyl compound". Pharmacological Research (2024): 107353. https://www.sciencedirect.com/science/article/pii/S1043661824002986?via%3Dihub.
    Acesso aberto • Publicado • 10.1016/j.phrs.2024.107353
  4. R. G. Teixeira, J. P. Mészáros, B. Matos, L. Côrte-Real, C. P. R. Xavier, X. Fontrodona, I. Romero, G. Spengler, M. H. G. "Novel family of [RuCp(N,N)(P)]+ compounds with simultaneous anticancer and antibacterial activity: Biological evaluation and solution chemistry studies". European Journal of Medicinal Chemistry (2023): https://doi.org/10.1016/j.ejmech.2023.115922.
    10.1016/j.ejmech.2023.115922
  5. R. G. Teixeira, I. C. Salaroglio, N. F. B. Oliveira, J. S. G. Sequeira, X. Fontrodona, I. Romero, M. Machuqueiro, A. I.. "Fighting Multidrug Resistance with Ruthenium-Cyclopentadienyl Compounds: Unveiling the Mechanism of P-gp Inhibition". Journal of Medicinal Chemistry (2023): https://doi.org/10.1021/acs.jmedchem.3c01120.
    10.1021/acs.jmedchem.3c01120
  6. O. Dömötör, R. G. Teixeira, G. Spengler, F. Avecilla, F. Marques, O. A. Lenis-Rojas, C. P. Matos, R. F. M. de Almeida, É. "Ruthenium(II) polypyridyl complexes with benzothiophene and benzimidazole derivatives: Synthesis, antitumor activity, solution studies and biospeciation". Journal of Inorganic Biochemistry 238 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85141813123&partnerID=MN8TOARS.
    10.1016/j.jinorgbio.2022.112058
  7. C. Teixeira-Guedes, A. R. Brás, R. G. Teixeira, A. Valente, A. Preto. "Ruthenium(II)–Cyclopentadienyl-Derived Complexes as New Emerging Anti-Colorectal Cancer Drugs". Pharmaceutics (2022): https://www.mdpi.com/1999-4923/14/6/1293.
    10.3390/pharmaceutics14061293
  8. O. A. Lenis-Rojas, M. P. Robalo, A. I. Tomaz, A. R. Fernandes, C. Roma-Rodrigues, R. G. Teixeira, F. Marques, M. Folguei. "Half-Sandwich Ru(p-cymene) Compounds with Diphosphanes: In Vitro and in Vivo Evaluation As Potential Anticancer Metallodrugs". Inorganic Chemistry 60 5 (2021): 2914-2930. http://www.scopus.com/inward/record.url?eid=2-s2.0-85101518659&partnerID=MN8TOARS.
    10.1021/acs.inorgchem.0c02768
  9. R. G. Teixeira, D. C. Belisario, X. Fontrodona, I. Romero, M. H. Garcia, C. Riganti, A. Valente. "Unprecedented collateral sensitivity for cisplatin-resistant lung cancer cells presented by new ruthenium organometallic compounds". Inorganic Chemistry Frontiers 8 8 (2021): 1983-1996. http://www.scopus.com/inward/record.url?eid=2-s2.0-85104708664&partnerID=MN8TOARS.
    10.1039/d0qi01344g
  10. R.G. Teixeira, F. Marques, M.P. Robalo, X. Fontrodona, M.H. Garcia, S.G.Crich , C. Viñas, A. Valente. "Ruthenium carboranyl complexes with 2,2'-bipyridine derivatives for potential bimodal therapy application". RSC Advances 10 28 (2020): 16266-16276. http://dx.doi.org/10.1039/d0ra01522a.
    10.1039/d0ra01522a
  11. L. Côrte-Real, R. G. Teixeira, P. Gírio, E. Comsa, A. Moreno, R. Nasr, H. Baubichon-Cortay, F. Avecilla, F. Marques, M.. "Methyl-cyclopentadienyl Ruthenium Compounds with 2,2'-Bipyridine Derivatives Display Strong Anticancer Activity and Multidrug Resistance Potential". Inorganic Chemistry (2018): http://dx.doi.org/10.1021/acs.inorgchem.8b00358.
    10.1021/acs.inorgchem.8b00358
  12. R. G. Teixeira, A. R. Brás, L. Côrte-Real, R. Tatikonda, A. Sanches, M. P. Robalo, F. Avecilla, M. H. Garcia, A. Preto,. "Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand showing strong activity towards colorectal cancer cell lines". European Journal of Medicinal Chemistry 143 -- (2018): 503-514. https://www.sciencedirect.com/science/article/pii/S0223523417309625.
    Publicado • 10.1016/
Capítulo de livro
  1. A. Valente, T. S. Morais, R. G. Teixeira, C. P. Matos, M. H. Garcia, A. I. Tomaz. "Ruthenium and iron metallodrugs: New inorganic and organometallic complexes as prospective anticancer agents". In Synthetic Inorganic Chemistry | New Perspectives Developments in Inorganic Chemistry, 223-276. 2021.
    Publicado
Poster em conferência
  1. C. Henriques, D. B. Baptista, R. G. Teixeira, A. Valente, A. M. M. Antunes. "Pharmacokinetic profiling of Ruthenium and Selenium hit compounds: guiding the optimization of alternative therapeutic options to overcome multidrug resistance in cancer treatment". Trabalho apresentado em 4th Chem&BioChem Postgraduate Students Meeting, 2024.
  2. C. Henriques, D. B. Baptista, R. G. Teixeira, A. Valente, C. Riganti, A. Antunes,. "Overcoming cancer multidrug resistance using combinatorial therapy based on selenium and ruthenium compounds". Trabalho apresentado em CQE Days 2024 Spring Meeting, 2024.
  3. R. G. Teixeira, B. Tahhan, X. Fontrodona, I. Romero, M. H. Garcia, A. Valente, I. Romero-Canélon, A. I. Tomaz. "Towards luminescent Ru(II)-polypyridyl-biotin complexes as phototoxic agents for cancer treatment". Trabalho apresentado em 3rd Chem&BioChem Postgraduate Students Meeting, 2023.
  4. R. G. Teixeira, L. Côrte-Real, J. P. Mészáros, X. Fontrodona, I. Romero, G. Spengler, M. H. Garcia, É. A. Enyedy, A. I.. "Exploring the effect of phosphane functionalization on ‘RuCp’ complexes: from synthesis to biological evaluation". Trabalho apresentado em CQE Days 2023 Spring Meeting, 2023.
  5. A. Stefanelli, R. G. Teixeira, A. Pilon, R. Warmers, I. Ott, C. R. Kowol, A. Brozovic, A. I. Tomaz, A. Valente, P. Heffe. "Anticancer activity and paraptosis induction of novel bipyridine-silver(I) compounds against resistant colorectal and ovarian cancer cells". Trabalho apresentado em American Association for Cancer Research Annual Meeting, 2023.
  6. R. G. Teixeira, D. Belisario, C. Riganti, S. Saponara, D. Stefanova, V. Tzankova, Y. Yordanov, M. H. Garcia, A. I. Tomaz. "Overcoming multidrug resistance in lung cancer: a preeminent role for Ru cyclopentadienyl agents". Trabalho apresentado em 2nd Chem&BioChem Postgraduate Students Meeting, 2022.
  7. R. G. Teixeira, D. Belissario, N. F. B. Oliveira, J. G. N. Sequeira, B. Gorelli, S. Saponara, C. Riganti, M. Machuqueiro. "Targeting cancer multidrug resistance in lung cancer cells with Ru-cyclopentadienyl compounds: a structure-activity study". Trabalho apresentado em COSTAction 17104 Session Meeting, 2022.
  8. A. Stefanelli, R. G. Teixeira, A. Pilon, R..Warmers, P. J. Costa, M. J. Villa de Brito, A. Brozovic, A. I. Tomaz, A. Val. "Anticancer activity of novel bipyridine-silver(I) compounds against resistant colorectal and ovarian cancer cell lines". Trabalho apresentado em COSTAction 17104 Session Meeting, 2022.
  9. R. G. Teixeira, D. Belisario, N. F. B. Oliveria, J. G. N. Sequeira, I. Romero, C. Riganti, M. Machuqueiro, A. I. Tomaz,. "Targeting P-gp with Ru-cyclopentadienyl compounds: an approach to overcome cancer multidrug resistance". Trabalho apresentado em CQE Days 2021 Spring Meeting, 2021.
  10. I. C. Maximiano, C. Teixeira-Guedes, R. G. Teixeira, A. R. Brás, A. Preto, A. Antunes, A. Valente. "[Ru(CpR’)(PPh3)(bipy-R)]+ family of compounds: prospective anticancer metallodrugs with a promising large spectrum of activity". Trabalho apresentado em CQE Days 2021 Spring Meeting, 2021.
  11. A. Pilon, R. G. Teixeira, X. Fontrodona, I. Romero, A. Stefanelli, X. Hudec, V. Tadic, M. Pernar, A. I. Tomaz, M. H. Gar. "Silver(I) complexes containing different bipyridine and phosphane-based ligands as potent anti-cancer agents". Trabalho apresentado em CQE Days 2021 Spring Meeting, 2021.
  12. R. G. Teixeira, F. Marques, M. P. Robalo, X. F. Gubau, M. H. Garcia, S. G. Crich, C. Viñas, A. Valente. "Ruthenacarborane complexes bearing N,N-ligands for potential bimodal therapy application". Trabalho apresentado em ENCONTRO CIÊNCIA ´20, 2020.
  13. R. G. Teixeira, D. C. Belisario, A. I. Tomaz, M. H. Garcia, C. Riganti, A. Valente. "Ruthenium organometallic compounds as ABC drug efflux-targeted agents and collateral sensitizers". Trabalho apresentado em 6th International Electronic Conference on Medicinal Chemistry, electronic conference, 2020.
  14. R. G. Teixeira, F. Marques, M. P. Robalo, X. F. Gubau, M. H. Garcia, S. G. Crich, C.Viñas, A. Valente. "Ruthenacarboranes complexes bearing N,N- ligands for potential bimodal therapy application". Trabalho apresentado em CQE Days 2020 Spring Meeting, 2020.
  15. R. G. Teixeira, X. F. Gubau, F. Marques, M. P. Robalo, M. H. Garcia, C. Viñas, A. Valente. "Synthesis of half-sandwich ruthenacarboranes complexes incorporating N-donor ligands as eminent candidates for Boron Neutron Capture Therapy". Trabalho apresentado em Ciências Research Day 2019, 2019.
  16. R. G. Teixeira, F. Avecilla, M. P. Robalo, J. Lorenzo, S. Rodriguez-Calado, S. Santos, M. H. Garcia, A. I. Tomaz. "Novel Ruthenium-based metallodrugs bearing thiosemicarbazone ligands: from synthesis and antitumor activity to serum albumin interaction.". Trabalho apresentado em 4th Meeting of the College of Chemistry of the University of Lisbon (4ECQUL), 2019.
  17. R. G. Teixeira, X. F. Gubau, F. Marques, M. P. Robalo, M. H. Garcia, C. Viñas, A. Valente. "Synthesis of half-sandwich ruthenacarboranes complexes incorporating N-donor ligands as eminent candidates for Boron Neutron Capture Therapy". Trabalho apresentado em CQE days Spring Meeting 2019, 2019.
  18. R. G. Teixeira, A. Valente, F. Avecilla, M. P. Robalo, S. Santos, M. H. Garcia, A. I. Tomaz. "Structure, Electrochemistry and Anticancer activity of Novel Thiosemicarbazone Complexes of Ruthenium(II)". Trabalho apresentado em 12th Inorganic and Bioinorganic Chemistry Conference, 2018.
  19. R. G. Teixeira, A. Valente, F. Avecilla, M. P. Robalo, S. Santos, M. H. Garcia, A. I. Tomaz. "Novel Ruthenium(II)-thiosemicarbazone complexes: synthesis, electrochemistry and antitumoral activity". Trabalho apresentado em 3rd Meeting of the College of Chemistry of the University of Lisbon (3ECQUL), 2018.
  20. R. G. Teixeira, A. Sanches, L. Côrte-Real, F. Avecilla, M. H. Garcia, A. Valente. "New ruthenium-methylcyclopentadienyl family of anticancer agents: synthesis, characterization and in vitro studies". Trabalho apresentado em 1st Chem&BioChem Postgraduate Students Meeting, 2017.
  21. A. S. Assis, A. C. Poeta, R. G. Teixeira, A. Valente, F. Marques, M. P. Robalo, S. Santos, A. I. Tomaz, M. H. Garcia,. "Novel ruthenium(II) thiosemicarbazone complexes as anticancer metallodrug candidates". Trabalho apresentado em 11th Inorganic Chemistry Conference, 2016.
Tese / Dissertação
  1. "Targeting cancer with ruthenium compounds". Doutoramento, Universidade de Lisboa Faculdade de Ciências, 2024. https://biblios.ciencias.ulisboa.pt/detalhes/61917.
  2. "Synthesis of new 3D-eta5-carboranyl and eta5-methylcyclopentadienyl ruthenium complexes incorporating bipyridine (macro)ligands as promising anticancer agents". Mestrado, Universidade de Lisboa Faculdade de Ciências, 2017. https://repositorio.ulisboa.ptbitstream/10451/31808/1/ulfc124336_tm_Ricardo_Teixeira.pdf.
  3. "Development of new metallodrugs for cancer therapy". Licenciatura, Universidade de Lisboa Faculdade de Ciências, 2014.

Outros

Outra produção
  1. Front Cover Journal of Medicinal Chemistry journal (67, 8, pages 6081–6098, April 2023). Front cover artwork highlighting the paper "Paraptotic Cell Death as an Unprecedented Mode of Action Observed for New Bipyridine-Silver(I) Compounds Bearing Phosphane Coligands". 2024. https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01036. 2024. Ricardo G. Teixeira. https://pubs.acs.org/toc/jmcmar/67/8.
    10.1021/acs.jmedchem.3c01036
  2. Front Cover Journal of Medicinal Chemistry journal (66, 20, pages 14080-14094, October 2023). Front cover artwork highlighting the paper "Fighting Multidrug Resistance with Ruthenium–Cyclopentadienyl Compounds: Unveiling the Mechanism of P-gp Inhibition". 2023. R.G. Teixeira, I.C. Salaroglio, N.F.B. Oliveira, J.G.N. Sequeira, X. Fontrodona, I. Romero, M. Machuqueiro, A.I. Tomaz, M.H. Garcia, C. Riganti, A. Valente https://pubs.acs.org/doi/10.1021/acs.jmedchem.3c01120. 2023. Ricardo G. Teixeira. https://doi.org/10.1021/acs.jmedchem.3c01120.
    10.1021/acs.jmedchem.3c01120
  3. Inside Front Cover Inorganic Chemistry Frontiers (Number 8, Volume 8, April 2021). Inside Front Cover highlighting the paper "Unprecedented collateral sensitivity for cisplatin-resistant lung cancer cells presented by new ruthenium organometallic compounds". 2021. R.G. Teixeira, D.C. Belisario, X. Fontrodona, Isabel Romero, A.I. Tomaz, M.H. Garcia, C. Riganti, A. Valente. https://pubs.rsc.org/en/content/articlelanding/2021/qi/d0qi01344g.
    10.1039/D0QI01344G
  4. HOT Topic - Inorganic Chemistry Frontiers (Number 8, Volume 8, April 2021).. This paper was highlighted as one of the 2021 Inorganic Chemistry Frontiers HOT articles.. 2021. R. G. Teixeira, D. C. Belisario, X. Fontrodona, I. Romero, M. H. Garcia, C. Riganti, A. Valente. https://pubs.rsc.org/en/journals/articlecollectionlanding?sercode=qi&themeid=8fdbbab8-17f4-4a27-b70d-92b58944731d.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/12/18 Understanding P-gp inhibition by RuCp compounds using a Molecular Docking protocol The Portuguese Community of Structural Bioinformatics Researchers – 2nd Annual Meeting
(Coimbra, Portugal)
2023/05/25 A new prospective ruthenium-cyclopentadienyl compound as cancer multidrug resistance reversing agent CQE Days 2023 Spring Meeting
(Lisboa, Portugal)
2022/06/05 On the anticancer activity and biospeciation of ruthenium(II) polypyridyl complexes International Symposium on Metal Complexes
(Valencia, Espanha)
2021/05/27 Overcoming cisplatin resistance in lung cancer using Ru(II) organometallic compounds CQE Days 2021 Spring Meeting
(Lisboa, Portugal)
2020/05/28 Ruthenacarborane complexes bearing N,N- ligands for potential bimodal therapy application CQE Days 2020 Spring Meeting
(Lisboa, Portugal)
2018/07/30 Novel ruthenium methylcyclopentadienyl complexes bearing bipyridine based ligands with strong anticancer activity 43th International Conference on Coordination Chemistry
(Sendai, Japão)
2018/03/01 Novel ruthenium cyclopentadienyl complexes bearing bipyridine based (macro)ligands with strong activity towards cancer cells 4th European Conference on Smart Inorganic Polymers (SIPs)
(Zagreb, Croácia)
2017/12/04 ABC proteins: targets for ruthenium- cyclopentadienyl anticancer compounds? II International Caparica Christmas Congress on Translational Chemistry
(Setúbal, Portugal)
2017/08/06 'Ruthenium-cyclopentadienyl’ moiety: a versatile scaffold for the design of anticancer agents. SILQCOM 2017
(Puerto Iguazú, Argentina)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2020 - 2021 Desenvolvimento de metalofármacos de ruténio para a terapia do cancro (PT) | Development of Ru-based metallodrugs for the therapy of cancer (EN)
Coorientador de Ana Sofia Oliveira
BSc in Chemistry | Final Graduation Project (Licenciatura/Bacharelato)
Universidade de Lisboa Faculdade de Ciências, Portugal
2019 - 2020 Novos complexos de ruténio contendo benzonitrilos derivatizados como potenciais agentes anticancerígenos (PT) | New ruthenium complexes containing derivatized benzonitriles as potential anticancer agents (EN)
Coorientador de Jorge Valentim
BSC in Chemistry | Final Graduation Project (Licenciatura/Bacharelato)
Universidade de Lisboa Faculdade de Ciências, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2021/08 - 2021/08 Cost Action CA18202 Network for Equilibria and Chemical Thermodynamics Advanced Research (NECTAR) (2021/08 - 2021/08)
Conferência (Membro da Comissão Organizadora)
 Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2011/09 - 2011/09 Glycosciences in the International year of the Chemistry, Applications to Human Health and Disease (2011/09 - 2011/09)
Conferência (Membro da Comissão Organizadora)
 Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2011/05 - 2011/05 Participation in the organization of the Open Day of FCUL- 2011 (2011/05 - 2011/05)
Exposição (Coorganizador)
 Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2011/04 - 2011/04 Participation in the organization of "Chemistry Olympiads - 2011" (2011/04 - 2011/04)
Outro (Coorganizador)
 Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2019/10/19 - Atual Ciências Research Day | Poster presentation and discussion | Title: "Synthesis of half-sandwich ruthenacarboranes complexes incorporating N-donor ligand as eminent candidates for boron neutron capture therapy"
Simpósio
 Ciências Research Day | FCUL
Universidade de Lisboa Faculdade de Ciências, Portugal
2024/06/27 - 2024/06/27 Flash/pitch presentations session - Chairman
Encontro
 4th Chem&BioChem Postgraduate Students Meeting
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2024/04/10 - 2024/04/10 Facilities and Group introduction | Leiden´s University visits Faculty of Sciences of University of Lisbon
Exposição
 Leiden University visita Ciências ULisboa
Universidade de Lisboa Faculdade de Ciências, Portugal
2022/05/04 - 2022/05/04 Facilities and Group Introduction | Dias Abertos da FCUL | Faculdade de Ciências da Universidade de Lisboa
Exposição
 OpenDays@Ciências
2021/10/27 - 2021/10/27 Open labs activity
Simpósio
 Ciências Research Day 2021
Universidade de Lisboa Faculdade de Ciências, Portugal
2021 - 2021 | Outreach Activity | IYPT - International Year of the Periodic Table | Flashmob Flashmob involving both students and professors/researchers, each identified as an Element of the Periodic Table. Performed on the Periodic Table paint at the entrance of C8 building (FCUL). The event was filmed by air and on the ground. https://youtu.be/bmVMJoynb1Q
Exposição
 FlashMob | International Year of the Periodic Table
Universidade de Lisboa Departamento de Química e Bioquímica, Portugal

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2024/09/30 Design de novos complexos organometálicos de Ruténio(II) e Cobalto(III)-ciclopentadienilo para o tratamento do cancro (PT) | Design of new Ru(II) and Co(III) organometallic complexes for the treatment of cancer (EN) | Final Graduation Project (BSc in Chemistry)
Arguente principal
 Salomé Freire Fuchs (Outro)
Universidade de Lisboa Faculdade de Ciências, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2019/02 - 2019/07 Laboratory of Synthesis and Development of Products Química Tecnológica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal

Tutoria

Tópico Nome do aluno
2024/07 - 2024/08 3rd year student of the NOVA University of Lisboa | BSc in Biochemistry | Summer project entitled: “Synthesis of prospective Ruthenium-based compounds as anti-cancer agents” | Supervised by Tânia Morais (FCUL) Vitor Silva
2024/06 - 2024/07 1st year student from the Faculty of Sciences | BSc in Chemistry; 1-month research period | Introduction to the good practices in an Organometallic Laboratory | Supervised by Tânia Morais (FCUL) Denis David
2023/02 - 2023/12 Student of the Instituto Superior Técnico |PhD in Chemistry| "Multifunctional Ruthenium and Selenium Drugs to Overcome Multidrug Resistance in Cancer" | Supervised by Andreia Valente (FCUL) and Alexandra Antunes (IST) Catarina Henriques
2023/02 - 2023/08 Student in Chemical And Pharmaceutical Sciences And Biotechnology from the University of Camerino (Italy) | 6-month research period | Supervised by Andreia Valente Daphne Romani
2022/09 - 2022/12 2nd year student from the Faculty of Sciences | MSc in Chemistry | "Development of metal complexes of (reduced) Schiff bases as prospective anticancer agents" | Supervised by Ana Isabel Tomaz (FCUL) and Isabel Correia(IST) Mariana Dias Machado
2022/04 - 2022/07 2nd year student from the University and Technological Institute of Béthune, Erasmus Summer Project | “Development of iron-polymer conjugates for cancer therapy” | Supervised by Andreia Valente (FCUL) Camille Gelle
2020/09 - 2020/10 3rd year student – Graduate Engineering Programme from École Nationale Superieure de Chimie de Lille | Erasmus Summer Project | “New ruthenium compounds as prospective metallodrugs” | Supervised by Andreia Valente (FCUL) Amélie da Silva
2019/02 - 2019/06 3rd year student from the Faculty of Sciences | BSc in Chemistry | "The role of serum proteins in the distribution and mode of action of prospective anticancer metallodrugs" | Final Graduation Project | Supervised by Ana Isabel Tomaz (FCUL) Joana André
2019/02 - 2019/06 3rd year student from the Faculty of Sciences | BSc in Chemistry | "Development of new Ru-based metallodrugs for cancer therapy" | Final Graduation Project | Supervised by Ana Isabel Tomaz (FCUL) Sara Neves
2019/02 - 2019/03 Student of the Department of Inorganic and Analytical Chemistry from the University of Szeged | 1-month research period | Supervised by Ana Isabel Tomaz (FCUL, PI of Transnational Research Program Portugal-Hungary) János Peter Mészáros
Distinções

Prémio

2023 Extension of the PhD Grant due to the pandemic (COVID/BD/153190/2023)
Fundação para a Ciência e a Tecnologia, Portugal
2018 PhD Grant (SFRH/BD/135830/2018)
Fundação para a Ciência e a Tecnologia, Portugal

Outra distinção

2017 Short-term scientific mission (STSM) grant for young researchers exchange