Identificação pessoal

Nome completo

Tommy Regen

Nomes de citação

• Regen, Tommy

Identificadores de autor

Ciência ID

871E-2DEC-8069

ORCID iD

0000-0002-7275-3330

Telefones

Telefone

• (+49) 6131179210 (Profissional)

Moradas

• Langenbeckstr. 1, 55131, Mainz, -, Alemanha (Profissional)

Websites

• https://www.unimedizin-mainz.de/molekulare-medizin/home.html?L=1 (Académico)

Domínios de atuação

• Ciências Médicas e da Saúde - Medicina Básica - Imunologia
• Ciências Médicas e da Saúde - Medicina Básica - Neurociências
• Ciências Naturais - Ciências Biológicas

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Alemão (Idioma materno)
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Francês	Utilizador elementar (A2)	Utilizador independente (B2)	Utilizador elementar (A2)	Utilizador independente (B2)	Utilizador elementar (A2)

	Grau	Classificação
2006 - 2010 Concluído	Neuroimmunology (Doktor (PhD)) Georg-August-Universität Göttingen Göttinger Graduiertenzentrum für Neurowissenschaften Biophysik und Molekulare Biowissenschaften, Alemanha "Dr. rer. nat. (PhD)" (TESE/DISSERTAÇÃO)
2004 - 2006 Concluído	Biotechnology (Master) Brandenburgische Technische Universität Cottbus-Senftenberg - Campus Senftenberg, Alemanha
2000 - 2004 Concluído	Biotechnology (Bachelor) Brandenburgische Technische Universität Cottbus-Senftenberg - Campus Senftenberg, Alemanha

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2012 - Atual	Pós-doutorado (Investigação)	University Medical Center of the Johannes Gutenberg University Mainz, Alemanha
	Institute for Molecular Medicine, Alemanha
2011 - 2012	Pós-doutorado (Investigação)	Georg-August-Universität Göttingen Institut für Neuropathologie, Alemanha

Publicações

Artigo em revista

Miguel Ribeiro; Helena C. Brigas; Mariana Temido-Ferreira; Paula A. Pousinha; Tommy Regen; Cátia Santa; Joana E. Coelho; et al. "Meningeal ¿d T cell–derived IL-17 controls synaptic plasticity and short-term memory". Science Immunology 4 40 (2019): eaay5199-eaay5199. https://doi.org/10.1126/sciimmunol.aay5199. 10.1126/sciimmunol.aay5199 Regen, Tommy. "IL-17A/F in Leishmania major-resistant C57BL/6 mice.". Experimental dermatology (2019): https://doi.org/10.1111/exd.13896. 10.1111/exd.13896 Regen, Tommy. "Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation.". Cell reports (2019): https://europepmc.org/articles/PMC6389594. 10.1016/j.celrep.2019.01.070 Regen, Tommy. "Alternative Splice Forms of CYLD Mediate Ubiquitination of SMAD7 to Prevent TGFB Signaling and Promote Colitis.". Gastroenterology (2018): https://doi.org/10.1053/j.gastro.2018.10.023. 10.1053/j.gastro.2018.10.023 Regen, Tommy. "Expression of IL-17F is associated with non-pathogenic Th17 cells.". Journal of molecular medicine (Berlin, Germany) (2018): https://doi.org/10.1007/s00109-018-1662-5. 10.1007/s00109-018-1662-5 Regen, Tommy. "RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation.". Frontiers in immunology (2018): https://europepmc.org/articles/PMC5890188. 10.3389/fimmu.2018.00587 Regen, Tommy. "IL-4 Receptor Alpha Signaling through Macrophages Differentially Regulates Liver Fibrosis Progression and Reversal.". EBioMedicine (2018): https://europepmc.org/articles/PMC5925448. 10.1016/j.ebiom.2018.01.028 Regen, Tommy. "Interferon-¿-Driven iNOS: A Molecular Pathway to Terminal Shock in Arenavirus Hemorrhagic Fever.". Cell host & microbe (2017): https://doi.org/10.1016/j.chom.2017.07.008. 10.1016/j.chom.2017.07.008 Regen, Tommy. "A presumed antagonistic LPS identifies distinct functional organization of TLR4 in mouse microglia.". Glia (2017): https://doi.org/10.1002/glia.23151. 10.1002/glia.23151 Regen, Tommy. "Corrigendum: Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.". Nature immunology (2017): https://doi.org/10.1038/ni0417-474b. 10.1038/ni0417-474b Regen, Tommy. "TGF-ß inhibitor Smad7 regulates dendritic cell-induced autoimmunity.". Proceedings of the National Academy of Sciences of the United States of America (2017): https://europepmc.org/articles/PMC5338403. 10.1073/pnas.1615065114 Regen, Tommy. "Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells.". Nature immunology (2016): https://europepmc.org/articles/PMC5164931. 10.1038/ni.3632 Regen, Tommy. "IL-1 signaling is critical for expansion but not generation of autoreactive GM-CSF+ Th17 cells.". The EMBO journal (2016): https://europepmc.org/articles/PMC5210124. 10.15252/embj.201694615 Regen, Tommy. "Generation of a Novel T Cell Specific Interleukin-1 Receptor Type 1 Conditional Knock Out Mouse Reveals Intrinsic Defects in Survival, Expansion and Cytokine Production of CD4 T Cells.". PloS one (2016): https://europepmc.org/articles/PMC4995027. 10.1371/journal.pone.0161505 Regen, Tommy. "TLR4-activated microglia require IFN-¿ to induce severe neuronal dysfunction and death in situ.". Proceedings of the National Academy of Sciences of the United States of America (2015): https://europepmc.org/articles/PMC4711883. 10.1073/pnas.1513853113 Regen, Tommy. "CD14 is a key organizer of microglial responses to CNS infection and injury.". Glia (2015): https://doi.org/10.1002/glia.22955. 10.1002/glia.22955 Regen, Tommy. "Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System.". Immunity (2015): https://doi.org/10.1016/j.immuni.2015.06.012. 10.1016/j.immuni.2015.06.012 Regen, Tommy. "Tyrphostin AG126 exerts neuroprotection in CNS inflammation by a dual mechanism.". Glia (2015): https://doi.org/10.1002/glia.22803. 10.1002/glia.22803 Regen, Tommy. "The role of IL-17 in CNS diseases.". Acta neuropathologica (2015): https://doi.org/10.1007/s00401-015-1402-7. 10.1007/s00401-015-1402-7 Regen, Tommy. "IFN-¿-producing CD4+ T cells promote generation of protective germinal center-derived IgM+ B cell memory against Salmonella Typhi.". Journal of immunology (Baltimore, Md. : 1950) (2014): https://doi.org/10.4049/jimmunol.1302526. 10.4049/jimmunol.1302526 Regen, Tommy. "A new model for primary-progressive multiple sclerosis?". Acta neuropathologica (2013): https://doi.org/10.1007/s00401-013-1179-5. 10.1007/s00401-013-1179-5 Regen, Tommy. "Empty liposomes induce antitumoral effects associated with macrophage responses distinct from those of the TLR1/2 agonist Pam3CSK 4 (BLP).". Cancer immunology, immunotherapy : CII (2013): https://doi.org/10.1007/s00262-013-1444-4. 10.1007/s00262-013-1444-4 Regen, Tommy. "Histone deacetylase inhibitors suppress immune activation in primary mouse microglia.". Journal of neuroscience research (2013): https://doi.org/10.1002/jnr.23221. 10.1002/jnr.23221 Regen, Tommy. "Resistance of the brain to Escherichia coli K1 infection depends on MyD88 signaling and the contribution of neutrophils and monocytes.". Infection and immunity (2013): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23478323/?tool=EBI. 10.1128/IAI.01349-12 Regen, Tommy. "Toll-like receptor activation reveals developmental reorganization and unmasks responder subsets of microglia.". Glia (2012): https://doi.org/10.1002/glia.22409. 10.1002/glia.22409 Regen, Tommy. "The nucleotide-binding oligomerization domain-containing-2 ligand muramyl dipeptide enhances phagocytosis and intracellular killing of Escherichia coli K1 by Toll-like receptor agonists in microglial cells.". Journal of neuroimmunology (2012): https://doi.org/10.1016/j.jneuroim.2012.07.012. 10.1016/j.jneuroim.2012.07.012 Regen, Tommy. "Reduced astrocytic NF-¿B activation by laquinimod protects from cuprizone-induced demyelination.". Acta neuropathologica (2012): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22766690/?tool=EBI. 10.1007/s00401-012-1009-1 Regen, Tommy. "Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis.". Journal of cell science (2011): https://doi.org/10.1242/jcs.074088. 10.1242/jcs.074088 Regen, Tommy. "CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS.". Brain, behavior, and immunity (2010): https://doi.org/10.1016/j.bbi.2010.10.009. 10.1016/j.bbi.2010.10.009 Regen, Tommy. "Inflammatory cytokine release of astrocytes in vitro is reduced by all-trans retinoic acid.". Journal of neuroimmunology (2010): https://doi.org/10.1016/j.jneuroim.2010.08.005. 10.1016/j.jneuroim.2010.08.005 Regen, Tommy. "Microglia promote colonization of brain tissue by breast cancer cells in a Wnt-dependent way.". Glia (2010): https://doi.org/10.1002/glia.21022. 10.1002/glia.21022 Regen, Tommy. "The viral TLR3 agonist poly(I:C) stimulates phagocytosis and intracellular killing of Escherichia coli by microglial cells.". Neuroscience letters (2010): https://doi.org/10.1016/j.neulet.2010.06.078. 10.1016/j.neulet.2010.06.078 Regen, Tommy. "Inflammatory chemokine release of astrocytes in vitro is reduced by all-trans retinoic acid.". Journal of neurochemistry (2010): https://doi.org/10.1111/j.1471-4159.2010.06867.x. 10.1111/j.1471-4159.2010.06867.x Regen, Tommy. "T cell-dependence of Lassa fever pathogenesis.". PLoS pathogens (2010): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20360949/?tool=EBI. 10.1371/journal.ppat.1000836 Regen, Tommy. "Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine.". Proceedings of the National Academy of Sciences of the United States of America (2010): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20231476/?tool=EBI. 10.1073/pnas.0909586107 Regen, Tommy. "Fibronectin stimulates Escherichia coli phagocytosis by microglial cells.". Glia (2010): https://doi.org/10.1002/glia.20929. 10.1002/glia.20929 Regen, Tommy. "Toll-like receptor stimulation enhances phagocytosis and intracellular killing of nonencapsulated and encapsulated Streptococcus pneumoniae by murine microglia.". Infection and immunity (2009): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19933834/?tool=EBI. 10.1128/IAI.01110-09 Regen, Tommy. "Toll-like receptor prestimulation increases phagocytosis of Escherichia coli DH5alpha and Escherichia coli K1 strains by murine microglial cells.". Infection and immunity (2008): https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18981243/?tool=EBI. 10.1128/IAI.00903-08 Regen, Tommy. "Manipulation of host hepatocytes by the malaria parasite for delivery into liver sinusoids.". Science (New York, N.Y.) (2006): https://doi.org/10.1126/science.1129720. 10.1126/science.1129720 Regen, Tommy. "A new clinically relevant approach to expand myelin specific T cells.". Journal of immunological methods (2006): https://doi.org/10.1016/j.jim.2005.12.009. 10.1016/j.jim.2005.12.009

Prémio

2019	3rd Poster Prize awarded at the 1st Immunology & Inflammation conference in Berlin, Germany Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft, Alemanha
2019	Best Talk Award at the annual Meeting of the DGfI study group T cells: Subsets and Functions in Marburg, Germany Deutsche Gesellschaft für Immunologie eV, Alemanha
2018	Travel Grant to participate at ISNI Meeting, Brisbane, AUS International Society of Neuroimmunology, Itália
2017	1st Poster Prize awarded at the 2nd IL-17 SUMMIT in Munich, Germany Deutsche Gesellschaft für Immunologie eV, Alemanha
2016	1st Poster Prize awarded at the 1st IL-17 SUMMIT in Munich, Germany Deutsche Gesellschaft für Immunologie eV, Alemanha
2013	Travel Grant to participate at ISN Satellite Meeting, Merida, Mexico Deutsche Gesellschaft für Immunologie eV, Alemanha
2013	Travel Grant to participate at ISN Satellite Meeting, Merida, Mexico International Society for Neurochemistry, Suiça
2012	Travel Grant to participate at ECI Meeting, Glasgow, UK European Federation of Immunological Societies, Países Baixos
2010	Bridging Fund for finalization of PhD Thesis Georg-August-Universität Göttingen Göttinger Graduiertenzentrum für Neurowissenschaften Biophysik und Molekulare Biowissenschaften, Alemanha
2005	DAAD stipend for the realization of the Master Thesis (Montreal, QC, Canada) Deutscher Akademischer Austauschdienst, Alemanha
2003	DAAD stipend for the realization of the Bachelor Thesis (Montreal, QC, Canada) Deutscher Akademischer Austauschdienst, Alemanha