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Jorge Ruas is Professor of Molecular Physiology and group leader for the Molecular and Cellular Exercise Physiology research group (Dept. of Physiology and Pharmacology, Karolinska Institutet). He received his Pharm.D. degree from the University of Lisbon, Portugal, after which he initiated pre-doctoral work at Karolinska Institutet. During his doctoral studies he investigated how cellular oxygen levels can regulate gene expression, and in 2005 received his Ph.D. in Cell and Molecular Biology. In 2006 he moved to Boston to pursue postdoctoral studies at the Division of Metabolism and Chronic Disease at the Dana-Farber Cancer Institute and Harvard Medical School. During this period he focused on the study of transcriptional networks that control skeletal muscle physiology. Jorge Ruas set up his laboratory at the Department of Physiology and Pharmacology at Karolinska Institutet in July 2011. His research group studies the molecular physiology of physical exercise and how to use this knowledge to develop novel therapies. He has published 78 papers with over 11,000 citations.
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Identificação

Identificação pessoal

Nome completo
Jorge Lira Ruas

Nomes de citação

  • Ruas, Jorge
  • Ruas, JL

Identificadores de autor

Ciência ID
8B1B-9CDD-BEED
ORCID iD
0000-0002-1110-2606

Websites

  • www.ruaslab.science (Profissional)

Domínios de atuação

  • Ciências Médicas e da Saúde - Ciências da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Sueco Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B2) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
1999 - 2005
Concluído
 Medical Sciences (Doktor (PhD))
Karolinska Institutet, Suécia
"Oxygen-dependent regulation of transcription by the Hypoxia-inducible Factor-1" (TESE/DISSERTAÇÃO)
1989 - 1995
Concluído
 Ciências Farmacêuticas (Licenciatura)
Universidade de Lisboa Faculdade de Farmácia, Portugal
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2023/11/01 - Atual Investigador principal (carreira) (Investigação) University of Michigan Medical School, Estados Unidos
2011/07/01 - Atual Investigador principal (carreira) (Investigação) Karolinska Institutet, Suécia
Karolinska Institutet, Suécia
2018 - 2023/10/31 Investigador principal convidado (carreira) (Investigação) Universidade de Lisboa Faculdade de Farmácia, Portugal
Projetos

Bolsa

Designação Financiadores
2019/07/01 - 2024/06/30 Novo Nordisk Fonden Ascending Investigator in Endocrinology and Metabolism
NNF19OC0054132
Investigador responsável
Karolinska Institutet, Suécia
 Novo Nordisk Fonden
Em curso
2017/01/01 - 2022/12/31 Swedish Research Council Consolidator Grant
2016-00785
Investigador responsável
Vetenskapsradet
2014/05 - 2017/04 Modeling information flow between tissues during metabolic adaptation and dysfunction
HFSPGAYOUNG20147
 Human Frontiers Science Program
Produções

Publicações

Artigo em revista
  1. Ducommun S; Jannig PR; Cervenka I; MARTA MURGIA; Mittenbühler MJ; Chernogubova E; Dias JM; et al. "Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition.". Molecular metabolism (2024): https://europepmc.org/articles/PMC10950823.
    10.1016/j.molmet.2024.101912
  2. Caria I; Nunes MJ; Ciraci V; Carvalho AN; Ranito C; Santos SG; Maria João Gama; et al. "NPC1-like phenotype, with intracellular cholesterol accumulation and altered mTORC1 signaling in models of Parkinson's disease.". Biochimica et biophysica acta. Molecular basis of disease (2023): https://doi.org/10.1016/j.bbadis.2023.166980.
    10.1016/j.bbadis.2023.166980
  3. Nunes MJ; Carvalho AN; Sá-Lemos C; Colaço M; Cervenka I; Ciraci V; Santos SG; et al. "Sustained PGC-1a2 or PGC-1a3 expression induces astrocyte dysfunction and degeneration.". European journal of cell biology (2023): https://doi.org/10.1016/j.ejcb.2023.151377.
    10.1016/j.ejcb.2023.151377
  4. Joel Spratt; José Dias; Christina Kolonelou; Georges Kiriako; Enya Engström; Ekaterina Petrova; Christos Karampelias; et al. "Multivalent insulin receptor activation using insulin-DNA origami nanostructures.". Nature nanotechnology (2023): https://europepmc.org/articles/PMC10873203.
    10.1038/s41565-023-01507-y
  5. Joana Saraiva Rodrigues; Andreia Faria-Pereira; Sérgio Póvoas Camões; Ana Sofia Serras; Vanessa Alexandra Morais; Jorge Lira Ruas; Joana Paiva Miranda. "Improving human mesenchymal stem cell-derived hepatic cell energy metabolism by manipulating glucose homeostasis and glucocorticoid signaling". Frontiers in Endocrinology 13 (2023): http://dx.doi.org/10.3389/fendo.2022.1043543.
    10.3389/fendo.2022.1043543
  6. Qing Luo; Han-pin Pui; Jiayu Chen; Leqian Yu; Paulo R. Jannig; Yu Pei; Linxuan Zhao; et al. "Epiblast-like stem cells established by Wnt/ß-catenin signaling manifest distinct features of formative pluripotency and germline competence". Cell Reports 42 1 (2023): 112021-112021. http://dx.doi.org/10.1016/j.celrep.2023.112021.
    10.1016/j.celrep.2023.112021
  7. Correia, JC; Jannig, PR; Gosztyla, ML; Cervenka, I; Ducommun, S; Præstholm, SM; Dumont, K; et al. "Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration". bioRxiv (2023): http://www.ncbi.nlm.nih.gov/pubmed/37398033.
    10.1101/2023.06.12.544338
  8. Tomi Tuomainen; Nikolay Naumenko; Maija Mutikainen; Anastasia Shakirzyanova; Sarah Sczelecki; Jennifer L. Estall; Jorge L. Ruas; Pasi Tavi. "PGC-1a4 Interacts with REST to Upregulate Neuronal Genes and Augment Energy Consumption in Developing Cardiomyocytes". Cells (2022): https://doi.org/10.3390/cells11192944.
    10.3390/cells11192944
  9. Hannes Schihada; Thomas Maarten Klompstra; Laura Humphrys; Igor Cervenka; Shamim Dadvar; Peter Kolb; Jorge L. Ruas; Gunnar Schulte. "Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer coupling and mediate intracellular pathway bias". Journal of Biological Chemistry 298 9 (2022): 102328-102328. http://dx.doi.org/10.1016/j.jbc.2022.102328.
    10.1016/j.jbc.2022.102328
  10. Shuijie Li; Wenyu Li; Juan Yuan; Petra Bullova; Jieyu Wu; Xuepei Zhang; Yong Liu; et al. "Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome". Nature Metabolism 4 6 (2022): 739-758. http://dx.doi.org/10.1038/s42255-022-00593-x.
    10.1038/s42255-022-00593-x
  11. "SnapShot: Regulation and biology of PGC-1a.". Cell (2022): https://doi.org/10.1016/j.cell.2022.03.027.
    10.1016/j.cell.2022.03.027
  12. Erwin Ilegems; Galyna Bryzgalova; Jorge Correia; Burcak Yesildag; Edurne Berra; Jorge L. Ruas; Teresa S. Pereira; Per-Olof Berggren. "HIF-1a inhibitor PX-478 preserves pancreatic ß cell function in diabetes". Science Translational Medicine 14 638 (2022): https://doi.org/10.1126/scitranslmed.aba9112.
    10.1126/scitranslmed.aba9112
  13. Oehler, D; Spychala, A; Gödecke, A; Lang, A; Gerdes, N; Ruas, J; Kelm, M; Szendroedi, J; Westenfeld, R. "Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1a promoters and isoforms regulated distinctly in myocardial ischemia and obesity". BMC Biol (2022): http://www.ncbi.nlm.nih.gov/pubmed/35907957.
    10.1186/s12915-022-01360-w
  14. "Mitochondrial NDUFA4L2 is a novel regulator of skeletal muscle mass and force.". FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2021): https://doi.org/10.1096/fj.202100066R.
    10.1096/fj.202100066r
  15. "Changes in plasma concentration of kynurenine following intake of branched-chain amino acids are not caused by alterations in muscle kynurenine metabolism.". American journal of physiology. Cell physiology (2021): https://doi.org/10.1152/ajpcell.00285.2021.
    10.1152/ajpcell.00285.2021
  16. "Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism.". Nature communications (2021): https://europepmc.org/articles/PMC8511155.
    10.1038/s41467-021-26095-0
  17. "Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity.". Cell metabolism (2021): https://doi.org/10.1016/j.cmet.2021.09.003.
    10.1016/j.cmet.2021.09.003
  18. "The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?". Trends in molecular medicine (2021): https://doi.org/10.1016/j.molmed.2021.07.006.
    10.1016/j.molmed.2021.07.006
  19. Paula Valente-Silva; Igor Cervenka; Duarte M. S. Ferreira; Jorge C. Correia; Sebastian Edman; Oscar Horwath; Ruiwen Benjamin Heng; et al. "Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans". Metabolites (2021): https://www.mdpi.com/2218-1989/11/8/508.
    10.3390/metabo11080508
  20. Nikolay Naumenko; Maija Mutikainen; Lari Holappa; Jorge L Ruas; Tomi Tuomainen; Pasi Tavi. "PGC-1a deficiency reveals sex-specific links between cardiac energy metabolism and EC-coupling during development of heart failure in mice". Cardiovascular Research (2021): https://doi.org/10.1093/cvr/cvab188.
    10.1093/cvr/cvab188
  21. "Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling.". BMC biology (2021): https://europepmc.org/articles/PMC7989211.
    10.1186/s12915-021-00979-5
  22. "High-intensity leg cycling alters the molecular response to resistance exercise in the arm muscles.". Scientific reports (2021): https://europepmc.org/articles/PMC7979871.
    10.1038/s41598-021-85733-1
  23. Song, Ki-Young; Correia, Jorge; Ruas, Jorge L.; Teixeira, Ana I.. "Effects of topological constraints on the alignment and maturation of multinucleated myotubes". Biotechnology and Bioengineering (2021): http://dx.doi.org/10.1002/bit.27731.
    10.1002/bit.27731
  24. Wu, Haohao; Petitpré, Charles; Fontanet, Paula; Sharma, Anil; Bellardita, Carmelo; Quadros, Rolen M.; Jannig, Paulo R.; et al. "Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice". Nature Communications 12 1 (2021): http://dx.doi.org/10.1038/s41467-021-21173-9.
    10.1038/s41467-021-21173-9
  25. Ruas, JL. "Comparative Analysis of Skeletal Muscle Transcriptional Signatures Associated With Aerobic Exercise Capacity or Response to Training in Humans and Rats.". Frontiers in endocrinology (2020): https://europepmc.org/articles/PMC7649134.
    10.3389/fendo.2020.591476
  26. Ruas, JL. "Topologically selective islet vulnerability and self-sustained downregulation of markers for ß-cell maturity in streptozotocin-induced diabetes.". Communications biology (2020): https://europepmc.org/articles/PMC7527346.
    10.1109/tmi.2011.2161590
  27. Martin, Kyle; Azzolini, Michele; Ruas, Jorge L.. "The Kynurenine connection: how exercise shifts muscle tryptophan metabolism and affects energy homeostasis, the immune system, and the brain.". American Journal of Physiology-Cell Physiology (2020): http://dx.doi.org/10.1152/ajpcell.00580.2019.
    10.1152/ajpcell.00580.2019
  28. Hermes Taylor-Weiner; Christopher L. Grigsby; Duarte M. S. Ferreira; José M. Dias; Molly M. Stevens; Jorge L. Ruas; Ana I. Teixeira. "Modeling the transport of nuclear proteins along single skeletal muscle cells". Proceedings of the National Academy of Sciences 117 6 (2020): 2978-2986. https://doi.org/10.1073/pnas.1919600117.
    10.1073/pnas.1919600117
  29. Léveillé, M; Besse-Patin, A; Jouvet, N; Gunes, A; Sczelecki, S; Jeromson, S; Khan, NP; et al. "PGC-1a isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments". Mol Metab (2020): http://www.ncbi.nlm.nih.gov/pubmed/32180561.
    10.1016/j.molmet.2020.01.004
  30. Peleli, M; Ferreira, DMS; Tarnawski, L; McCann Haworth, S; Xuechen, L; Zhuge, Z; Newton, PT; et al. "Dietary nitrate attenuates high-fat diet-induced obesity via mechanisms involving higher adipocyte respiration and alterations in inflammatory status". Redox Biol (2020): http://www.ncbi.nlm.nih.gov/pubmed/31765889.
    10.1016/j.redox.2019.101387
  31. Correia, JC; Ruas, JL. "Exercised cytokines promote endurance". Science (2020): http://www.ncbi.nlm.nih.gov/pubmed/32355018.
    10.1126/science.abb4116
  32. Cronfalk, BS; Akesson, E; Nygren, J; Nystrom, A; Strandell, AM; Ruas, J; von Euler, M. "A qualitative study-Patient experience of tactile massage after stroke". NURS. OPEN (2020):
    10.1002/nop2.515
  33. Alves, CRR; Neves, WD; de Almeida, NR; Eichelberger, EJ; Jannig, PR; Voltarelli, VA; Tobias, GC; et al. "Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN". Mol Metab (2020): http://www.ncbi.nlm.nih.gov/pubmed/32408015.
    10.1016/j.molmet.2020.101012
  34. Ruas, Jorge. "Skeletal muscle PGC-1a1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance". Nature Communications (2019): http://dx.doi.org/10.1038/s41467-019-10712-0.
    10.1038/s41467-019-10712-0
  35. Ferreira, DMS; Cheng, AJ; Agudelo, LZ; Cervenka, I; Chaillou, T; Correia, JC; Porsmyr-Palmertz, M; et al. "LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force". Skelet Muscle (2019): http://www.ncbi.nlm.nih.gov/pubmed/31666122.
    10.1186/s13395-019-0214-1
  36. Ruas, Jorge. "Transcriptomic analysis of the development of skeletal muscle atrophy in cancer-cachexia in tumor-bearing mice". Physiological Genomics (2018): http://dx.doi.org/10.1152/physiolgenomics.00061.2018.
    10.1152/physiolgenomics.00061.2018
  37. S. Dadvar; D. M. S. Ferreira; I. Cervenka; J. L. Ruas. "The weight of nutrients: kynurenine metabolites in obesity and exercise". Journal of Internal Medicine 284 5 (2018): 519-533. https://doi.org/10.1111/joim.12830.
    10.1111/joim.12830
  38. Agudelo, LZ; Ferreira, DMS; Cervenka, I; Bryzgalova, G; Dadvar, S; Jannig, PR; Pettersson-Klein, AT; et al. "Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation". Cell Metab. (2018): http://www.ncbi.nlm.nih.gov/pubmed/29414686.
    10.1016/j.cmet.2018.01.004
  39. Pettersson-Klein, AT; Izadi, M; Ferreira, DMS; Cervenka, I; Correia, JC; Martinez-Redondo, V; Southern, M; et al. "Small molecule PGC-1a1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration". Mol Metab (2018): http://www.ncbi.nlm.nih.gov/pubmed/29428596.
    10.1016/j.molmet.2018.01.017
  40. Mills, R; Taylor-Weiner, H; Correia, JC; Agudelo, LZ; Allodi, I; Kolonelou, C; Martinez-Redondo, V; et al. "Neurturin is a PGC-1a1-controlled myokine that promotes motor neuron recruitment and neuromuscular junction formation". Mol Metab (2018): http://www.ncbi.nlm.nih.gov/pubmed/29157948.
    10.1016/j.molmet.2017.11.001
  41. Bayindir-Buchhalter, I; Wolff, G; Lerch, S; Sijmonsma, T; Schuster, M; Gronych, J; Billeter, AT; et al. "Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors". EMBO Mol Med (2018): http://www.ncbi.nlm.nih.gov/pubmed/29973382.
    10.15252/emmm.201708613
  42. Kärkkäinen, O; Tuomainen, T; Mutikainen, M; Lehtonen, M; Ruas, JL; Hanhineva, K; Tavi, P. "Heart specific PGC-1a deletion identifies metabolome of cardiac restricted metabolic heart failure". Cardiovasc. Res. (2018): http://www.ncbi.nlm.nih.gov/pubmed/29931052.
    10.1093/cvr/cvy155
  43. Igor Cervenka; Leandro Z. Agudelo; Jorge L. Ruas. "Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health". Science 357 6349 (2017): eaaf9794-eaaf9794. https://doi.org/10.1126/science.aaf9794.
    10.1126/science.aaf9794
  44. Ruby MA; Massart J; Hunerdosse DM; Schönke M; Correia JC; Louie SM; Ruas JL; et al. "Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance.". (2017): http://europepmc.org/abstract/med/28099843.
    10.1016/j.celrep.2016.12.070
  45. Jannig PR; Ruas JL. "Targeting mitochondrial mRNA translation to tackle obesity-induced insulin resistance: thumbs up for exercise.". (2017): http://europepmc.org/abstract/med/27419811.
    10.1111/apha.12752
  46. Mutikainen M; Tuomainen T; Naumenko N; Huusko J; Smirin B; Laidinen S; Kokki K; et al. "Peroxisome proliferator-activated receptor-¿ coactivator 1 a1 induces a cardiac excitation-contraction coupling phenotype without metabolic remodelling.". (2016): http://europepmc.org/abstract/med/27716916.
    10.1113/JP272847
  47. Cipriano M; Correia JC; Camões SP; Oliveira NG; Cruz P; Cruz H; Castro M; et al. "The role of epigenetic modifiers in extended cultures of functional hepatocyte-like cells derived from human neonatal mesenchymal stem cells.". (2016): http://europepmc.org/abstract/med/27909741.
    10.1007/s00204-016-1901-x
  48. Zepf FD; Stewart RM; Guillemin G; Ruas JL. "Inflammation, immunology, stress and depression: a role for kynurenine metabolism in physical exercise and skeletal muscle.". (2016): http://europepmc.org/abstract/med/26832995.
    10.1017/neu.2015.69
  49. Salah H; Li M; Cacciani N; Gastaldello S; Ogilvie H; Akkad H; Namuduri AV; et al. "The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction.". (2016): http://europepmc.org/abstract/med/27488897.
    10.1126/scitranslmed.aaf7099
  50. Moutinho M; Nunes MJ; Correia JC; Gama MJ; Castro-Caldas M; Cedazo-Minguez A; Rodrigues CM; et al. "Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk.". (2016): http://europepmc.org/abstract/med/27491694.
    10.1038/srep30928
  51. Corpeno Kalamgi R; Salah H; Gastaldello S; Martinez-Redondo V; Ruas JL; Fury W; Bai Y; et al. "Mechano-signalling pathways in an experimental intensive critical illness myopathy model.". (2016): http://europepmc.org/abstract/med/26990577.
    10.1113/jp271973
  52. Martínez-Redondo V; Jannig PR; Correia JC; Ferreira DM; Cervenka I; Lindvall JM; Sinha I; et al. "Peroxisome Proliferator-activated Receptor ¿ Coactivator-1 a Isoforms Selectively Regulate Multiple Splicing Events on Target Genes.". (2016): http://europepmc.org/abstract/med/27231350.
    10.1074/jbc.m115.705822
  53. Schlittler M; Goiny M; Agudelo LZ; Venckunas T; Brazaitis M; Skurvydas A; Kamandulis S; et al. "Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans.". (2016): http://europepmc.org/abstract/med/27030575.
    10.1152/ajpcell.00053.2016
  54. Place N; Ivarsson N; Venckunas T; Neyroud D; Brazaitis M; Cheng AJ; Ochala J; et al. "Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca2+ leak after one session of high-intensity interval exercise.". (2015): http://europepmc.org/abstract/med/26575622.
    10.1073/pnas.1507176112
  55. Correia JC; Massart J; de Boer JF; Porsmyr-Palmertz M; Martínez-Redondo V; Agudelo LZ; Sinha I; et al. "Bioenergetic cues shift FXR splicing towards FXRa2 to modulate hepatic lipolysis and fatty acid metabolism.". (2015): http://europepmc.org/abstract/med/26909306.
    10.1016/j.molmet.2015.09.005
  56. Martínez-Redondo V; Pettersson AT; Ruas JL. "The hitchhiker's guide to PGC-1a isoform structure and biological functions.". (2015): http://europepmc.org/abstract/med/26109214.
    10.1007/s00125-015-3671-z
  57. Ruas, JL. "Intercellular: local and systemic actions of skeletal muscle PGC-1s". (2015):
    10.1016/j.tem.2015.03.010
  58. White JP; Wrann CD; Rao RR; Nair SK; Jedrychowski MP; You JS; Martínez-Redondo V; et al. "G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy.". (2014): http://europepmc.org/abstract/med/25336758.
    10.1073/pnas.1417898111
  59. Agudelo, Leandro Z.; Femenía, Teresa; Orhan, Funda; Porsmyr-Palmertz, Margareta; Goiny, Michel; Martinez-Redondo, Vicente; Correia, Jorge C.; et al. "Skeletal Muscle PGC-1a1 Modulates Kynurenine Metabolism and Mediates Resilience to Stress-Induced Depression". Cell 159 1 (2014): 33-45. http://dx.doi.org/10.1016/j.cell.2014.07.051.
    10.1016/j.cell.2014.07.051
  60. Aesoy R; Gradin K; Aasrud KS; Hoivik EA; Ruas JL; Poellinger L; Bakke M. "Regulation of CDKN2B expression by interaction of Arnt with Miz-1 - a basis for functional integration between the HIF and Myc gene regulatory pathways.". (2014): http://europepmc.org/abstract/med/24618291.
    10.1186/1476-4598-13-54
  61. Sczelecki S; Besse-Patin A; Abboud A; Kleiner S; Laznik-Bogoslavski D; Wrann CD; Ruas JL; Haibe-Kains B; Estall JL. "Loss of Pgc-1a expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation.". (2014): http://europepmc.org/abstract/med/24280126.
    10.1152/ajpendo.00578.2013
  62. Rao, RR; Long, JZ; White, JP; Svensson, KJ; Lou, J; Lokurkar, I; Jedrychowski, MP; et al. "Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis". Cell (2014): http://www.ncbi.nlm.nih.gov/pubmed/24906147.
    10.1016/j.cell.2014.03.065
  63. Ruas, Jorge L.; White, James P.; Rao, Rajesh R.; Kleiner, Sandra; Brannan, Kevin T.; Harrison, Brooke C.; Greene, Nicholas P.; et al. "A PGC-1a Isoform Induced by Resistance Training Regulates Skeletal Muscle Hypertrophy". Cell 151 6 (2012): 1319-1331. http://dx.doi.org/10.1016/j.cell.2012.10.050.
    10.1016/j.cell.2012.10.050
  64. Wu, Jun; Ruas, Jorge L.; Estall, Jennifer L.; Rasbach, Kyle A.; Choi, Jang Hyun; Ye, Li; Boström, Pontus; et al. "The Unfolded Protein Response Mediates Adaptation to Exercise in Skeletal Muscle through a PGC-1a/ATF6a Complex". Cell Metabolism 13 2 (2011): 160-169. http://dx.doi.org/10.1016/j.cmet.2011.01.003.
    10.1016/j.cmet.2011.01.003
  65. Lustig, Y.; Ruas, J. L.; Estall, J. L.; Lo, J. C.; Devarakonda, S.; Laznik, D.; Choi, J. H.; et al. "Separation of the gluconeogenic and mitochondrial functions of PGC-1  through S6 kinase". Genes & Development 25 12 (2011): 1232-1244. http://dx.doi.org/10.1101/gad.2054711.
    10.1101/gad.2054711
  66. Rasbach KA; Gupta RK; Ruas JL; Wu J; Naseri E; Estall JL; Spiegelman BM. "PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types.". (2010): http://europepmc.org/abstract/med/21106753.
    10.1073/pnas.1016089107
  67. Choi, Jang Hyun; Banks, Alexander S.; Estall, Jennifer L.; Kajimura, Shingo; Boström, Pontus; Laznik, Dina; Ruas, Jorge L.; et al. "Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPAR¿ by Cdk5". Nature 466 7305 (2010): 451-456. http://dx.doi.org/10.1038/nature09291.
    10.1038/nature09291
  68. Ruas JL; Berchner-Pfannschmidt U; Malik S; Gradin K; Fandrey J; Roeder RG; Pereira T; Poellinger L. "Complex regulation of the transactivation function of hypoxia-inducible factor-1 alpha by direct interaction with two distinct domains of the CREB-binding protein/p300.". (2010): http://europepmc.org/abstract/med/19880525.
    10.1074/jbc.M109.021824
  69. Ruas, JL. "Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons". (2010):
    10.1242/dev.053348
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Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2018 - 2018 Astrocyte-specific Transcriptomic Response to PGC-1a3 Isoform
Orientador
 Ciências Biofarmacêuticas (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2018 Structure and function relationships in the family of PGC-1 transcriptional coactivators
Orientador
 Medical Sciences (Doutoramento)
Karolinska Institutet, Suécia
2012 - 2017/02 Skeletal Muscle PGC-1a1 and KAT enzymes at the intersection between depression and metabolic disease
Orientador
 Medical Sciences (Doutoramento)
Karolinska Institutet, Suécia
2016 - 2016 Characterization of Zinc Finger Protein 697 (Zfp697) localization and function in mouse brain
Orientador
 Biomedicine (Mestrado)
Karolinska Institutet, Suécia
2014 - 2014 Regulation of IGF1 and Myostatin by PGC-1a4
Orientador
 Biomedicine (Mestrado)
Université de Lille, França
2009 - 2014 Transcriptional Control of Energy Metabolism: Studies on FXR and PGC-1a
Coorientador
 Ciências Biológicas (Doutoramento)
Universidade do Algarve, Portugal
Distinções

Prémio

2022 2022 – Med Dr. Axel Hirsch Prize 2022.
Karolinska Institutet, Suécia
2019 Novo Nordisk Foundation Ascending Investigator in Endocrinology and Metabolism
Novo Nordisk Fonden, Dinamarca
2017 The Leif C. Groop Prize for Outstanding Diabetes Research
Lund University Diabetes Centre, Suécia
2014 Human Frontiers Science Program Young Investigator Award
Human Frontiers Science Program, França
2013 Lennart Philipson Prize & Grant in Biomedical Research
2011 Young Investigator Award in Diabetes.

Título

2006 Wenner-Gren Fellow
Wenner-Gren Stiftelserna, Suécia