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Identificação

Identificação pessoal

Nome completo
John Howl

Nomes de citação

  • Howl, John

Identificadores de autor

Ciência ID
8E1D-B154-2364
ORCID iD
0000-0001-9341-3717

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
1988/01
Concluído
 Molecular Pathology (Doctor)
University of Birmingham School of Biosciences, Reino Unido
"Calcium-mobilizing drugs an pathological changes in vertebrate skeletal muscle" (TESE/DISSERTAÇÃO)
 Pass
1984/06
Concluído
 BSc (Hons) Biological Sciences (Bachelor)
University of Birmingham School of Biosciences, Reino Unido
"N/A" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
1997/10/01 - Atual Investigador (Investigação) University of Birmingham School of Biosciences, Reino Unido
1993 - 1997 Investigador (Investigação) University of Birmingham School, Reino Unido
1988/10/01 - 1993/09/30 Investigador Auxiliar (carreira) (Investigação) University of Birmingham School, Reino Unido

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2006/08/01 - Atual Professor Catedrático (Docente Universitário) University of Wolverhampton Faculty of Science and Engineering, Reino Unido

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2011/01 - Atual Elected British Council Member of European Peptide Society European Peptide Society, Reino Unido
2007/01 - 2016/05 Managing Director of PanTechnia PLC University of Wolverhampton, Reino Unido
2005/03 - 2007/09 Enterprise Fellowship Scheme Honorary Fellow University of Wolverhampton, Reino Unido
2001/11/01 - 2006/07/31 Reader in Molecular Pharmacology University of Wolverhampton, Reino Unido
1997/09/01 - 2001/10/31 Senior lecturer in physiology/pharmacology. University of Wolverhampton, Reino Unido
Projetos

Bolsa

Designação Financiadores
2017/06/01 - 2017/08/31 Design, synthesis and evaluation of novel analogues of [Ser14]mitoparan, a new class of broad-spectrum antibiotic
Vacation scholarship
Orientador
University of Wolverhampton, Reino Unido
Concluído
2015/07/01 - 2017/06/30 The design and synthesis of rationally-designed cell penetrating modulators of signal transduction events in cancer cells.
Newton-Mosharafa Scholarship Fund
Orientador
University of Wolverhampton, Reino Unido
 British Council - Newton-Masharafa Fund
Concluído
2011/08/01 - 2012/07/31 Evaluation of LRRK2-derived bioportides as functional protein modulators and potential therapeutics
LRRK2 Challenge
Investigador responsável
University of Wolverhampton, Reino Unido
 Michael J Fox Foundation for Parkinson's Research
Concluído

Projeto

Designação Financiadores
2023 - Atual Physicochemical Optimization of STOPSPERM Bioportides for Clinical Utility
MCI Sokal Application
Investigador responsável
University of Wolverhampton, Reino Unido
Em curso
Produções

Publicações

Artigo em conferência
  1. Howl, John; Jones, S. "Regulated exocytosis of CPP-delivered cargoes from mast cells: A novel cell-mediated therapy?". Trabalho apresentado em Proceedings of the 34th European Peptide Symposium, 2017.
    No prelo
  2. Howl, John; Lukanowska, M.; Jones, S.. "Bioportide: A versatile class of bioactive cell penetrating peptide". Trabalho apresentado em PEPTIDES-2014: Proceedings of the 33rd European Peptide Symposium, 2015.
    Publicado
  3. Jones, S.; Lukanowska, M.; Howl, John. "Penetrating the impenetrable". Trabalho apresentado em PEPTIDES-2014: Proceedings of the 33rd European Peptide Symposium, 2015.
    Publicado
  4. Jones, S.; Lukanowska, M.; Howl, John. "Bioportides". Trabalho apresentado em Peptides 2012: Proceedings of the Thirty-Second European peptide Symposium, 2013.
    Publicado
  5. Howl, John; Jones, S.. "Anti-angiogenic properties of a rhegnylogically-organised cell penetrating peptide derived from endothelial nitric oxide synthase". Trabalho apresentado em Breaking Away: Proceedings of the 21st American Peptide Symposium, 2009.
  6. Jones, S.; Howl, John. "Targeting the nuclear pore complex with cell penetrating peptides: A novel therapeutic strategy". Trabalho apresentado em Breaking Away: Proceedings of the 21st American Peptide Symposium, 2009.
    Publicado
  7. Jones, S.; Martel, C.; Belzacq-Casagrande, A.; Brenner, Catherine; Howl, J.. "Mitoparans: mitochondriotoxic cell penetrating peptides and novel inducers of apoptosis". Trabalho apresentado em Proceedings of the 4th International Peptide Symposium, 2008.
    Publicado
  8. Jones, S.; Ostlund, P; Langel, U.; Zorko, M.I.; Nicholl, I.; Howl, John. "A Rhegnylogic Strategy for the Synthesis of Signal Transduction Modulatory, Cell Penetrating Peptides". Trabalho apresentado em Peptides 2006, 2007.
    Publicado
  9. Mall, J.; Howl, J; Darling, J.. "Peptide-conjugated nanoparticles for tumour-selective imaging and drug delivery". Trabalho apresentado em Peptides 2006, 2007.
    Publicado
  10. Baker, R.D.; Howl, John; Nicholl, I.D.. "Sensitivity of human carcinoma cell lines to a cytotoxic cell penetrant mimetic of P21". Trabalho apresentado em Peptides 2004, 2005.
    Publicado
  11. Jones, S.; Howl, John. "Amphiphilic peptide engineering: charge delocalization and the design of novel mastoparan analogues". Trabalho apresentado em Peptides 2004, 2005.
    Publicado
  12. Farquhar, M.J.; Soomets, Ursel; Brown, C.; Martin, A; Bates, R.; Langel, U.. "Venomous chimeric secretagogues". Trabalho apresentado em Peptides 2000, 2001.
    Publicado
  13. Brown, J.; Howl, John; Martin, A.; Langel, U.; Soomets, Ursel; Brown, C.. "Single amino-acid substitutions in a mimetic tertadecapeptide agonist of the human P2Y2 receptor prevent second messenger activation". Trabalho apresentado em Peptides 2000, 2001.
    Publicado
  14. Reading, Sarah J; Jones, S.; Howl, John; Martin, A.; Alexander, B.; Benjamini, I.S.; Brown, C.A.. "Functional responses to kinins in a novel hepatic artery cell line". Trabalho apresentado em Peptides 2000, 2001.
    Publicado
Artigo em revista
  1. Matos, Bárbara; Howl, John; Jerónimo, Carmen; Fardilha, Margarida. "Modulation of serine/threonine-protein phosphatase 1 (PP1) complexes: A promising approach in cancer treatment". Drug Discovery Today 26 11 (2021): 2680-2698. http://dx.doi.org/10.1016/j.drudis.2021.08.001.
    10.1016/j.drudis.2021.08.001
  2. Santiago, Joana; Silva, Joana V; Howl, John; Santos, Manuel A S; Fardilha, Margarida. "All you need to know about sperm RNAs". Human Reproduction Update 28 1 (2021): 67-91. http://dx.doi.org/10.1093/humupd/dmab034.
    10.1093/humupd/dmab034
  3. John Howl; Sarah Jones. "A new biology of cell penetrating peptides". Peptide Science 113 1 (2021): https://doi.org/10.1002/pep2.24154.
    10.1002/pep2.24154
  4. Matos, Bárbara; Patrício, Daniela; Henriques, Magda C.; Freitas, Maria J.; Vitorino, Rui; Duarte, Iola F.; Howl, John; et al. "Chronic exercise training attenuates prostate cancer-induced molecular remodelling in the testis". Cellular Oncology (2020): http://dx.doi.org/10.1007/s13402-020-00567-9.
  5. Silva, Joana Vieira; Freitas, Maria João; Santiago, Joana; Jones, Sarah; Guimarães, Sofia; Vijayaraghavan, Srinivasan; Publicover, Steven; et al. "Disruption of protein phosphatase 1 complexes with the use of bioportides as a novel approach to target sperm motility". Fertility and Sterility 115 2 (2020): 348-362. http://dx.doi.org/10.1016/j.fertnstert.2020.08.013.
  6. Matos, Bárbara; Howl, John; Jerónimo, Carmen; Fardilha, Margarida. "The disruption of protein-protein interactions as a therapeutic strategy for prostate cancer". Pharmacological Research 161 (2020): http://dx.doi.org/10.1016/j.phrs.2020.105145.
  7. Howl, John; Jones, Sarah. "A new biology of cell penetrating peptides". Peptide Science 113 1 (2020): http://dx.doi.org/10.1002/pep2.24154.
  8. Osman, Shaimaa; Jones, Sarah; Zewail, Mohamed; Rabie, Abdelgawad; Shalaby, Ahmed; Howl, John. "Microwave Assisted Peptide Synthesis of Some Rationally Designed Cell Penetrating Peptides from C-Kit Receptor". Egyptian Journal of Chemistry 0 0 (2019): 0-0. http://dx.doi.org/10.21608/ejchem.2019.7119.1611.
    Publicado • 10.21608/ejchem.2019.7119.1611
  9. Jones, Sarah; Osman, Shaimaa; Howl, John. "The planarian Schmidtea mediterranea as a model system for the discovery and characterization of cell-penetrating peptides and bioportides". Chemical Biology & Drug Design 93 6 (2019): 1036-1049. http://dx.doi.org/10.1111/cbdd.13483.
    Publicado • 10.1111/cbdd.13483
  10. Matos, Bárbara; Howl, John; Ferreira, Rita; Fardilha, Margarida. "Exploring the effect of exercise training on testicular function". European Journal of Applied Physiology 119 1 (2018): 1-8. http://dx.doi.org/10.1007/s00421-018-3989-6.
    Publicado • 10.1007/s00421-018-3989-6
  11. Howl, John; Howl, Lewis; Jones, Sarah. "The cationic tetradecapeptide mastoparan as a privileged structure for drug discovery: Enhanced antimicrobial properties of mitoparan analogues modified at position-14". Peptides 101 (2018): 95-105. http://dx.doi.org/10.1016/j.peptides.2018.01.007.
    Publicado • 10.1016/j.peptides.2018.01.007
  12. Jones, Sarah; Osman, Shaimaa; Howl, John. "A High-Throughput Synthetic Platform Enables the Discovery of Proteomimetic Cell Penetrating Peptides and Bioportides". International Journal of Peptide Research and Therapeutics 25 1 (2018): 1-8. http://dx.doi.org/10.1007/s10989-018-9681-1.
    Publicado • 10.1007/s10989-018-9681-1
  13. Richardson, Adam; Muir, Lewis; Mousdell, Sasha; Sexton, Darren; Jones, Sarah; Howl, John; Ross, Kehinde. "Modulation of mitochondrial activity in HaCaT keratinocytes by the cell penetrating peptide Z-Gly-RGD(DPhe)-mitoparan". BMC Research Notes 11 1 (2018): http://dx.doi.org/10.1186/s13104-018-3192-1.
    Publicado • 10.1186/s13104-018-3192-1
  14. Jones, Sarah; Uusna, Julia; Langel, Ülo; Howl, John. "Intracellular Target-Specific Accretion of Cell Penetrating Peptides and Bioportides: Ultrastructural and Biological Correlates". Bioconjugate Chemistry 27 1 (2015): 121-129. http://dx.doi.org/10.1021/acs.bioconjchem.5b00529.
    Publicado • 10.1021/acs.bioconjchem.5b00529
  15. Morris, Jennifer; Jones, Sarah; Howl, John; Lukanowska, Monika; Lefievre, Linda; Publicover, Stephen. "Cell-penetrating peptides, targeting the regulation of store-operated channels, slow decay of the progesterone-induced [Ca2+]isignal in human sperm". Molecular Human Reproduction 21 7 (2015): 563-570. http://dx.doi.org/10.1093/molehr/gav019.
    Publicado • 10.1093/molehr/gav019
  16. Howl, John; Jones, Sarah. "Cell penetrating peptide-mediated transport enables the regulated secretion of accumulated cargoes from mast cells". Journal of Controlled Release 202 (2015): 108-117. http://dx.doi.org/10.1016/j.jconrel.2015.02.005.
    Publicado • 10.1016/j.jconrel.2015.02.005
  17. Howl, John; Jones, Sarah. "Insights into the molecular mechanisms of action of bioportides: a strategy to target protein-protein interactions". Expert Reviews in Molecular Medicine 17 (2015): http://dx.doi.org/10.1017/erm.2014.24.
    Publicado • 10.1017/erm.2014.24
  18. Lukanowska, Monika; Howl, John; Jones, Sarah. "Bioportides: Bioactive cell-penetrating peptides that modulate cellular dynamics". Biotechnology Journal 8 8 (2013): 918-930. http://dx.doi.org/10.1002/biot.201200335.
    Publicado • 10.1002/biot.201200335
  19. Jones, S.; Lukanowska, M.; Suhorutsenko, J.; Oxenham, S.; Barratt, C.; Publicover, S.; Copolovici, D. M.; Langel, U.; Howl, J.. "Intracellular translocation and differential accumulation of cell-penetrating peptides in bovine spermatozoa: evaluation of efficient delivery vectors that do not compromise human sperm motility". Human Reproduction 28 7 (2013): 1874-1889. http://dx.doi.org/10.1093/humrep/det064.
    Publicado • 10.1093/humrep/det064
  20. Eriste, Elo; Kurrikoff, Kaido; Suhorutšenko, Julia; Oskolkov, Nikita; Copolovici, Dana Maria; Jones, Sarah; Laakkonen, Pirjo; Howl, John; Langel, Ülo. "Peptide-Based Glioma-Targeted Drug Delivery Vector gHoPe2". Bioconjugate Chemistry 24 3 (2013): 305-313. http://dx.doi.org/10.1021/bc300370w.
    Publicado • 10.1021/bc300370w
  21. Mehta, A.; Shervington, L.; Kurrikoff, K.; Howl, John; Jones, S.; Langel, U.; Shervington, A. "Can sihsp90a/CPP complex concomitant with 17-AAG be a therapy for cancer". FEBS Open Bio 3 (2013): 271-278.
    Publicado
  22. Howl, John; Matou-Nasri, Sabine; West, David C.; Farquhar, Michelle; Slaninová, Jirina; Östenson, Claes-Göran; Zorko, Matjaz; et al. "Bioportide: an emergent concept of bioactive cell-penetrating peptides". Cellular and Molecular Life Sciences 69 17 (2012): 2951-2966. http://dx.doi.org/10.1007/s00018-012-0979-4.
    Publicado • 10.1007/s00018-012-0979-4
  23. Jones, Sarah; Howl, John. "Enantiomer-Specific Bioactivities of Peptidomimetic Analogues of Mastoparan and Mitoparan: Characterization of Inverso Mastoparan as a Highly Efficient Cell Penetrating Peptide". Bioconjugate Chemistry 23 1 (2012): 47-56. http://dx.doi.org/10.1021/bc2002924.
    Publicado • 10.1021/bc2002924
  24. Jones, S.; Lukanowska, M.; Howl, John. "Bioportides". J. Pept. Sci. 18 S53 (2012):
    Publicado
  25. Jones, Sarah; Holm, Tina; Mäger, Imre; Langel, Ülo; Howl, John. "Characterization of Bioactive Cell Penetrating Peptides from Human Cytochrome c: Protein Mimicry and the Development of a Novel Apoptogenic Agent". Chemistry & Biology 17 7 (2010): 735-744. http://dx.doi.org/10.1016/j.chembiol.2010.05.018.
    Publicado • 10.1016/j.chembiol.2010.05.018
  26. Howl, John; Jones, Sarah. "Transport molecules using reverse sequence HIV-Tat polypeptides: not just any old Tat? (WO200808225)". Expert Opinion on Therapeutic Patents 19 9 (2009): 1329-1333. http://dx.doi.org/10.1517/17530050902824829.
    Publicado • 10.1517/17530050902824829
  27. Howl, John; Jones, S.. "Anti-angiogenic properties of a rhegnylogically-organised cell penetrating peptide derived from endothelial nitric oxide synthase". Bioploymers 92 362 (2009):
    Publicado
  28. Jones, S.; Howl, John. "Targeting the nuclear pore complex with cell penetrating peptides". Biopolymers (2009):
    Publicado
  29. Howl, John; Jones, Sarah. "Proteomimetic Cell Penetrating Peptides". International Journal of Peptide Research and Therapeutics 14 4 (2008): 359-366. http://dx.doi.org/10.1007/s10989-008-9135-2.
    Publicado • 10.1007/s10989-008-9135-2
  30. Farquhar, M. J.; Harris, H. J.; Diskar, M.; Jones, S.; Mee, C. J.; Nielsen, S. U.; Brimacombe, C. L.; et al. "Protein Kinase A-Dependent Step(s) in Hepatitis C Virus Entry and Infectivity". Journal of Virology 82 17 (2008): 8797-8811. http://dx.doi.org/10.1128/jvi.00592-08.
    Publicado • 10.1128/jvi.00592-08
  31. Jones, Sarah; Martel, Cecile; Belzacq-Casagrande, Anne-Sophie; Brenner, Catherine; Howl, John. "Mitoparan and target-selective chimeric analogues: Membrane translocation and intracellular redistribution induces mitochondrial apoptosis". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1783 5 (2008): 849-863. http://dx.doi.org/10.1016/j.bbamcr.2008.01.009.
    Publicado • 10.1016/j.bbamcr.2008.01.009
  32. Howl, John; Jones, S.. "A Modular Strategy for the Design of Apoptogenic Cell Penetrating Peptides.". J. Pept. Sci (2008):
    Publicado
  33. Howl, John; Jones, S.. "Modulating Biology with Cryptic Cell Penetrating Peptides". J. Pept. Sci. 14 16 (2008):
    Publicado
  34. Howl, J.; Nicholl, I.D.; Jones, S.. "The many futures for cell-penetrating peptides: how soon is now?". Biochemical Society Transactions 35 4 (2007): 767-769. http://dx.doi.org/10.1042/bst0350767.
    Publicado • 10.1042/bst0350767
  35. Baker, Rachael D.; Howl, John; Nicholl, Iain D.. "A sychnological cell penetrating peptide mimic of p21WAF1/CIP1 is pro-apoptogenic". Peptides 28 4 (2007): 731-740. http://dx.doi.org/10.1016/j.peptides.2006.12.013.
    Publicado • 10.1016/j.peptides.2006.12.013
  36. Jones, Sarah; Howl, John. "Biological Applications of the Receptor Mimetic Peptide Mastoparan". Current Protein & Peptide Science 7 6 (2006): 501-508. http://dx.doi.org/10.2174/138920306779025585.
    Publicado • 10.2174/138920306779025585
  37. Jones, Sarah; Farquhar, Michelle; Martin, Ashley; Howl, John. "Intracellular translocation of the decapeptide carboxyl terminal of Gi3a induces the dual phosphorylation of p42/p44 MAP kinases". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1745 2 (2005): 207-214. http://dx.doi.org/10.1016/j.bbamcr.2005.05.006.
    Publicado • 10.1016/j.bbamcr.2005.05.006
  38. Foreman, Megan A.; Gu, Yuchun; Howl, John D.; Jones, Sarah; Publicover, Stephen J.. "Group III metabotropic glutamate receptor activation inhibits Ca2+ influx and nitric oxide synthase activity in bone marrow stromal cells". Journal of Cellular Physiology 204 2 (2005): 704-713. http://dx.doi.org/10.1002/jcp.20353.
    Publicado • 10.1002/jcp.20353
  39. Jones, S.; Mall, J.; Howl, John. "Peptidyl-based delivery systems as a strategy for the therapeutic intervention of human astrocytoma and medulloblastoma". Biopolymers 80 (2005): 563-564.
    Publicado
  40. Howl, John; Farquhar, M. J.; Baker, R.; Nicholl, I.; Jones, S.. "Design, synthesis and applications of cell-penetrant peptides as signal transduction modulators". Biopolymers 80 555 (2005):
    Publicado
  41. Jones, S.; Howl, John. "Chimeric peptides as tumor-selective delivery systems". Neuro-oncology 7 373 (2005):
    Publicado
  42. Jones, Sarah; Howl, John. "Charge delocalisation and the design of novel mastoparan analogues: enhanced cytotoxicity and secretory efficacy of [Lys5, Lys8, Aib10]MP". Regulatory Peptides 121 1-3 (2004): 121-128. http://dx.doi.org/10.1016/j.regpep.2004.04.015.
    Publicado • 10.1016/j.regpep.2004.04.015
  43. Jones, Sarah; Howl, John. "Cannabinoid receptor systems: therapeutic targets for tumour intervention". Expert Opinion on Therapeutic Targets 7 6 (2003): 749-758. http://dx.doi.org/10.1517/14728222.7.6.749.
    Publicado • 10.1517/14728222.7.6.749
  44. Howl, John; Jones, Sarah; Farquhar, Michelle. "Intracellular Delivery of Bioactive Peptides to RBL-2H3 Cells Induces ß-Hexosaminidase Secretion and Phospholipase D Activation". ChemBioChem 4 12 (2003): 1312-1316. http://dx.doi.org/10.1002/cbic.200300694.
    Publicado • 10.1002/cbic.200300694
  45. Howl, John; Payne, Sarah J. "Bradykinin receptors as a therapeutic target". Expert Opinion on Therapeutic Targets 7 2 (2003): 277-285. http://dx.doi.org/10.1517/14728222.7.2.277.
    Publicado • 10.1517/14728222.7.2.277
  46. Farquhar, Michelle; Soomets, Ursel; Bates, Ruth L.; Martin, Ashley; Langel, Ülo; Howl, John. "Novel Mastoparan Analogs Induce Differential Secretion from Mast Cells". Chemistry & Biology 9 1 (2002): 63-70. http://dx.doi.org/10.1016/s1074-5521(01)00098-9.
    Publicado • 10.1016/s1074-5521(01)00098-9
  47. Gu, Y; Preston, M.R; El Haj, A.J; Howl, J.D; Publicover, S.J. "Three types of K+ currents in murine osteocyte-like cells (MLO-Y4)". Bone 28 1 (2001): 29-37. http://dx.doi.org/10.1016/s8756-3282(00)00439-7.
    Publicado • 10.1016/s8756-3282(00)00439-7
  48. Farquhar, M.J.; Martin, A; Bates, R.L.; Howl, John. "Experimental modulation of the facilitated uptake and constitutive exocytosis of 5-hydroxytryptamine in RBL-2H3 cells". Biogenic Amines 16 (2001): 593-604.
    Publicado
  49. Brown, Julia; Reading, Sarah J; Jones, Sarah; Fitchett, Caroline J; Howl, John; Martin, Ashley; Longland, Clare L; et al. "Critical Evaluation of ECV304 as a Human Endothelial Cell Model Defined by Genetic Analysis and Functional Responses: A Comparison with the Human Bladder Cancer Derived Epithelial Cell Line T24/83". Laboratory Investigation 80 1 (2000): 37-45. http://dx.doi.org/10.1038/labinvest.3780006.
    Publicado • 10.1038/labinvest.3780006
  50. Howl, John; Prochazka, Zdenko; Wheatley, Mark; Slaninová, Jirina. "Novel strategies for the design of receptor-selective vasopressin analogues: Aib-substitution and retro-inverso transformation". British Journal of Pharmacology 128 3 (1999): 647-652. http://dx.doi.org/10.1038/sj.bjp.0702857.
    Publicado • 10.1038/sj.bjp.0702857
  51. Gu, Y.; Preston, M.R.; El Haj, A.J.; Hamid, J.; Zamponi, G.W.; Howl, J.; Publicover, S.J.. "Osteoblasts derived from load-bearing bones of the rat express both L- and T-like voltage-operated calcium channels and mRNA for a1C, a1D and a1G subunits". Pflügers Archiv - European Journal of Physiology 438 4 (1999): 553-560. http://dx.doi.org/10.1007/s004249900083.
    Publicado • 10.1007/s004249900083
  52. Hällbrink, Mattias; Saar, Külliki; Östenson, Claes-Göran; Soomets, Ursel; Efendic, Suad; Howl, John; Wheatley, Mark; Zorko, Matjaz; Langel, Ülo. "Effects of vasopressin–mastoparan chimeric peptides on insulin release and G-protein activity". Regulatory Peptides 82 1-3 (1999): 45-51. http://dx.doi.org/10.1016/s0167-0115(99)00034-8.
    Publicado • 10.1016/s0167-0115(99)00034-8
  53. Howl, John. "Fluorescent and biotinylated probes for B2 bradykinin receptors: Agonists and antagonists". Peptides 20 4 (1999): 515-518. http://dx.doi.org/10.1016/s0196-9781(99)00033-9.
    Publicado • 10.1016/s0196-9781(99)00033-9
  54. Howl, John. "Chimeric ligands for G protein-coupled receptors". Collection Symposium Series 3 (1999): 9-12.
    Publicado
  55. Kuncarová, P.; Nazarov, E.; Howl, John; Slaninová, I.. "Full biological characterization of two linear vasopressin analogues _ [Phaa,D-Tyr(Et)2,Aib4,Arg6,Tyr(NH2)9]AVP and [Phaa,D-Tyr(Et)2,Arg6, Aib7,Tyr(NH2)9]AVP". Collection Symposium Series 3 (1999): 41-43.
    Publicado
  56. Longland, Clare L.; Mezna, Mokdad; Langel, Ülo; Hällbrink, Mattias; Soomets, Ursel; Wheatley, Mark; Michelangeli, Francesco; Howl, John. "Biochemical mechanisms of calcium mobilisation induced by mastoparan and chimeric hormonewmastoparan constructs". Cell Calcium 24 1 (1998): 27-34. http://dx.doi.org/10.1016/s0143-4160(98)90086-0.
    Publicado • 10.1016/s0143-4160(98)90086-0
  57. Sermasi, E.; Howl, J.; Wheatley, M.; Coote, J. H.. "Localisation of arginine vasopressin V 1a receptors on sympatho-adrenal preganglionic neurones". Experimental Brain Research 119 1 (1998): 85-91. http://dx.doi.org/10.1007/s002210050322.
    Publicado • 10.1007/s002210050322
  58. Howl, John; Mondszein, Richard M.; Wheatley, Mark. "Characterization of G Protein-Coupled Receptors Expressed by ECV304 Human Endothelial Cells". Endothelium 6 1 (1998): 23-32. http://dx.doi.org/10.3109/10623329809053402.
    Publicado • 10.3109/10623329809053402
  59. Howl, John; Wheatley, Mark. "Biochemical pharmacology of total retro-inverso analogues of bradykinin and angiotensin II: Molecular recognition by G protein-coupled receptors and angiotensin converting enzyme". Letters in Peptide Science 5 1 (1998): 1-5. http://dx.doi.org/10.1023/a:1008836814805.
    Publicado • 10.1023/a:1008836814805
  60. Howl, John; Langel, ülo; Wheatley, Mark. "Chimeric Hormones and Neuropeptides". Clinical Science 93 6 (1997): 605-606. http://dx.doi.org/10.1042/cs0930605.
    Publicado • 10.1042/cs0930605
  61. Wheatley, M.; Howl, J.; Yarwood, N. J.; Hawtin, S. R.; Davies, A. R. L.; Matthews, G.; Parslow, R. A.. "Structure and function of neurohypophysial hormone receptors". Biochemical Society Transactions 25 3 (1997): 1046-1051. http://dx.doi.org/10.1042/bst0251046.
    Publicado • 10.1042/bst0251046
  62. HOWL, JOHN. "Biotinylated and fluorescent analogues of bradykinin". Biochemical Society Transactions 25 3 (1997): 431S-431S. http://dx.doi.org/10.1042/bst025431s.
    Publicado • 10.1042/bst025431s
  63. YARWOOD, NICOLA. J.; HOWL, JOHN; LENG, GARETH; WHEATLEY, MARK. "Visualization of oxytocin receptors using selective biotinylated probes". Biochemical Society Transactions 25 3 (1997): 438S-438S. http://dx.doi.org/10.1042/bst025438s.
    Publicado • 10.1042/bst025438s
  64. HOWL, JOHN; MONDSZEIN, RICHARD; YARWOOD, NICOLA; WHEATLEY, MARK. "Chimeric analogues of vasopressin and bradykinin". Biochemical Society Transactions 25 3 (1997): 432S-432S. http://dx.doi.org/10.1042/bst025432s.
    Publicado • 10.1042/bst025432s
  65. MEZNA, MOKDAD; LANGEL, ÜLO; HÄLLBRINK, MATTIAS; WHEATLEY, MARK; MICHELANGELI, FRANCESCO; HOWL, JOHN. "Calcium-mobilizing actions of chimeric hormone-mastoparan peptides". Biochemical Society Transactions 25 3 (1997): 450S-450S. http://dx.doi.org/10.1042/bst025450s.
    Publicado • 10.1042/bst025450s
  66. YARWOOD, NICOLA. J.; HOWL, JOHN; WHEATLEY, MARK. "Characterization of the human oxytocin receptor ligand binding site". Biochemical Society Transactions 25 3 (1997): 436S-436S. http://dx.doi.org/10.1042/bst025436s.
    Publicado • 10.1042/bst025436s
  67. Howl, J; Langel, U; Hawtin, S R; Valkna, A; Yarwood, N J; Saar, K; Wheatley, M. "Chimeric strategies for the rational design of bioactive analogs of small peptide hormones.". The FASEB Journal 11 7 (1997): 582-590. http://dx.doi.org/10.1096/fasebj.11.7.9212082.
    Publicado • 10.1096/fasebj.11.7.9212082
  68. Howl, John; Yarwood, Nicola J.; Davies, Andrew R.L.; Wheatley, Mark. "Renal bradykinin and vasopressin receptors: Ligand selectivity and classification". Kidney International 50 2 (1996): 586-592. http://dx.doi.org/10.1038/ki.1996.353.
    Publicado • 10.1038/ki.1996.353
  69. HOWL, John; WHEATLEY, Mark. "Molecular recognition of peptide and non-peptide ligands by the extracellular domains of neurohypophysial hormone receptors". Biochemical Journal 317 2 (1996): 577-582. http://dx.doi.org/10.1042/bj3170577.
    Publicado • 10.1042/bj3170577
  70. Howl, J; Yarwood, N.J; Stock, D; Wheatley, M. "Probing the V1a vasopressin receptor binding site with pyroglutamate-substituted linear antagonists". Neuropeptides 30 1 (1996): 73-79. http://dx.doi.org/10.1016/s0143-4179(96)90058-x.
    Publicado • 10.1016/s0143-4179(96)90058-x
  71. Howl, John; Hawtin, S.R.; Mondszein, R.M.; Parslow, R. A.; Wheatley, M. "Chimeric and retro-inverso synthetic strategies for neuropeptides and peptide hormones: Pseudopeptidic analogues of bradykinin and vasopressin". Neurobiology 4 147 (1996):
    Publicado
  72. Wheatley, M; Yarwood, N.J; Parslow, R.A.; Hare, K.J.; Howl, John. "Biotinylated analogues of oxytocin and vasopressin: Probes for visualizing receptors at the cellular level in the CNS". Neurobiology 4 180 (1996):
    Publicado
  73. Howl, John; Wheatley, Mark. "Molecular pharmacology of V1a vasopressin receptors". General Pharmacology: The Vascular System 26 6 (1995): 1143-1152. http://dx.doi.org/10.1016/0306-3623(95)00016-t.
    Publicado • 10.1016/0306-3623(95)00016-t
  74. Howl, J; Rudge, S A; Lavis, R A; Davies, A R; Parslow, R A; Hughes, P J; Kirk, C J; Michell, R H; Wheatley, M. "Rat testicular myoid cells express vasopressin receptors: receptor structure, signal transduction, and developmental regulation.". Endocrinology 136 5 (1995): 2206-2213. http://dx.doi.org/10.1210/endo.136.5.7536665.
    Publicado • 10.1210/endo.136.5.7536665
  75. Howl, J.; Parslow, R. A.; Wheatley, M.. "Defining the ligand-binding site for vasopressin receptors: a peptide mimetic approach". Biochemical Society Transactions 23 1 (1995): 103-108. http://dx.doi.org/10.1042/bst0230103.
    Publicado • 10.1042/bst0230103
  76. Sermasi, Edoardo; Howl, John; Pyner, Susan; Wheatley, Mark; Coote, John H.. "Intramedullary Blood Vessels of the Spinal Cord Express V1a Vasopressin Receptors: Visualization by a Biotinylated Ligand". Neuroendocrinology 62 6 (1995): 634-639. http://dx.doi.org/10.1159/000127060.
    Publicado • 10.1159/000127060
  77. Howl, John; Filer, Andrew D.J.; Parslow, Rosemary A.; Kirk, Christopher J.; Jurzak, Mirek; Smith, A.Ian; Wheatley, Mark. "Pharmacological characterization of linear analogues of vasopressin generated by the systematic substitution of positions 1 and 6 by l-amino acids". Biochemical Pharmacology 47 9 (1994): 1497-1501. http://dx.doi.org/10.1016/0006-2952(94)90523-1.
    Publicado • 10.1016/0006-2952(94)90523-1
  78. Wheatley, Mark; Howl, John; Davies, Andrew R. L.; Parslow, Rosemary A.. "The study of neurohypophyseal hormone receptors by ligand binding". Biochemical Society Transactions 22 1 (1994): 113-118. http://dx.doi.org/10.1042/bst0220113.
    Publicado • 10.1042/bst0220113
  79. Wheatley, M; Howl, J; Morel, A; Davies, A R L. "Homology between neurohypophyseal hormone receptors". Biochemical Journal 296 2 (1993): 519-519. http://dx.doi.org/10.1042/bj2960519.
    Publicado • 10.1042/bj2960519
  80. Howl, John; Wheatley, Mark. "Hepatic vasopressin receptors (VPRs) exhibit species heterogeneity—absence of VPRs in sheep liver". Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 105 2 (1993): 247-250. http://dx.doi.org/10.1016/0742-8413(93)90202-v.
    Publicado • 10.1016/0742-8413(93)90202-v
  81. HOWL, John; WANG, Xianghong; KIRK, Christopher J.; WHEATLEY, Mark. "Fluorescent and biotinylated linear peptides as selective bifunctional ligands for the V1a vasopressin receptor". European Journal of Biochemistry 213 2 (1993): 711-719. http://dx.doi.org/10.1111/j.1432-1033.1993.tb17811.x.
    Publicado • 10.1111/j.1432-1033.1993.tb17811.x
  82. Sermasi, E.; Howl, John; Wheatley, M.; Coote, J. H.. "Colocalization of vasopressin V1a receptors and sympatho-adrenal preganglionic neurones in the neonate rat spinal cord". J. Physiol 467 (1993): 347P.
    Publicado
  83. Sermasi, E.; Howl, John; Wheatley, M; Pyner, S.; Coote, J. H.. "Arginine vasopressin V1a receptors are distributed on blood vessels of the spinal cord of the rat". J. Physiol 473 (1993): 251P.
    Publicado
  84. Howl, J.; New, D. C.; Wheatley, M.. "Design and synthesis of heterofunctional V1a-selective vasopressin receptor ligands with lysine at position 9". Journal of Molecular Endocrinology 9 2 (1992): 123-129. http://dx.doi.org/10.1677/jme.0.0090123.
    Publicado • 10.1677/jme.0.0090123
  85. Ismail, Tariq; Howl, John; Wheatley, Mark; McMaster, Paul; Neuberger, James M.; Strain, Alastair J.. "Growth of normal human hepatocytes in primary culture: Effect of hormones and growth factors on DNA synthesis". Hepatology 14 6 (1991): 1076-1082. http://dx.doi.org/10.1002/hep.1840140622.
    Publicado • 10.1002/hep.1840140622
  86. Howl, John; Strain, Alastair J.; Wheatley, Mark. "Human liver vasopressin receptors". Clinica Chimica Acta 200 2-3 (1991): 221-222. http://dx.doi.org/10.1016/0009-8981(91)90093-r.
    Publicado • 10.1016/0009-8981(91)90093-r
  87. Howl, J; Ismail, T; Strain, A J; Kirk, C J; Anderson, D; Wheatley, M. "Characterization of the human liver vasopressin receptor. Profound differences between human and rat vasopressin-receptor-mediated responses suggest only a minor role for vasopressin in regulating human hepatic function". Biochemical Journal 276 1 (1991): 189-195. http://dx.doi.org/10.1042/bj2760189.
    Publicado • 10.1042/bj2760189
  88. Howl, John; Kerr, Ian D.; Chan, Conrad H.W.; Wheatley, Mark. "A selective biotinylated probe for V1a vasopressin receptors". Molecular and Cellular Endocrinology 77 1-3 (1991): 123-131. http://dx.doi.org/10.1016/0303-7207(91)90066-2.
    Publicado • 10.1016/0303-7207(91)90066-2
  89. Howl, John; Kerr, Ian; Chan, Conrad H W; Wheatley, Mark. "Novel vasopressin receptor ligands". Biochemical Society Transactions 19 2 (1991): 87S-87S. http://dx.doi.org/10.1042/bst019087s.
    Publicado • 10.1042/bst019087s
  90. HOWL, JOHN; ISMAIL, TARIQ; STRAIN, ALASTAIR; WHEATLEY, MARK. "Do vasopressin receptors have a significant role in the hormonal regulation of human liver function?". Biochemical Society Transactions 18 3 (1990): 399-400. http://dx.doi.org/10.1042/bst0180399.
    Publicado • 10.1042/bst0180399
  91. Howl, J. D.; Publicover, S. J.. "Permeabilisation of the sarcolemma in mouse diaphragm exposed to Bay K 8644 in vitro: time course, dependence on Ca2+ and effects of enzyme inhibitors". Acta Neuropathologica 79 4 (1990): 438-443. http://dx.doi.org/10.1007/bf00308721.
    Publicado • 10.1007/bf00308721
  92. Howl, J.D.; Publicover, S.J.. "Lipidic mitochondrial inclusions in experimentally-induced in vitro myopathy of mouse diphragm". Comparative Biochemistry and Physiology Part B: Comparative Biochemistry 95 4 (1990): 833-837. http://dx.doi.org/10.1016/0305-0491(90)90325-n.
    Publicado • 10.1016/0305-0491(90)90325-n
  93. Howl, J. D.; Publicover, S. J.. "Bay K 8644 induced necrosis in murine skeletal muscle in vitro: myofibre breakdown precedes significant alterations of intracellular [Ca] or pH". Acta Neuropathologica 77 6 (1989): 634-644. http://dx.doi.org/10.1007/bf00687892.
    Publicado • 10.1007/bf00687892
  94. Howl, J. D.; von Sicard, N. A. E.; Publicover, S. J.; Anderson, M.. "A method for the manufacture of single barrel liquid ion-selective microelectrodes: an in situ study of ant venom pH". Pflügers Archiv 411 2 (1988): 212-215. http://dx.doi.org/10.1007/bf00582317.
    Publicado • 10.1007/bf00582317
  95. Howl, John; Publicover, S.J.. "Induction of myopathy in mammalian skeletal muscle in vitro by Bay K 8644". Neurosci. Lett. Suppl 29 (1987): S32.
    Publicado
  96. Howl, John; Publicover, S.J. "Induction of ultrastructural damage in mammalian cardiac and skeletal muscle by Bay K 8644". J. Physiol. 373 (1986): 61P.
    Publicado
Capítulo de livro
  1. Howl, John; Silva, Joana Vieira; Fardilha, Margarida; Jones, Sarah. "Protein Mimicry and the Design of Bioactive Cell-Penetrating Peptides: The Genesis of STOPSPERM Bioportides". In Methods in Molecular Biology, 293-306. Springer US, 2021.
    10.1007/978-1-0716-1752-6_20
  2. Howl, John; Jones, Sarah. "Protein Mimicry and the Design of Bioactive Cell-Penetrating Peptides". In Cell-penetrating peptides. Methods and Protocols, 177-190. Springer Press, 2015.
    Publicado • 10.1007/978-1-4939-2806-4_12
  3. Jones, Sarah; Howl, John. "Applications of Cell-Penetrating Peptides as Signal Transduction Modulators for the Selective Induction of Apoptosis". In Cell Penetrating Peptides: Methods and Protocols, 291-303. Springer Press, 2010.
    Publicado • 10.1007/978-1-60761-919-2_21
  4. Howl, John; Jones, S.. "Mastoparans". In Bioactive Peptides, 429-445. 2009.
    Publicado
  5. Jones, S.; Howl, John. "Modulating Biology with Cryptic Cell Penetrating Peptides". In Chemistry of Peptides in Life Science, Technology and Medicine. 2009.
    Publicado
  6. Howl, John; Farquhar, Michelle; Jones, Sarah. "Design, Synthesis and Applications of Cell-penetrant Peptides as Signal Transduction Modulators". In Understanding Biology Using Peptides, 397-398. Springer New York, 2006.
    Publicado • 10.1007/978-0-387-26575-9_164
  7. Jones, Sarah; Howl, John. "Peptidyl-based Delivery Systems as a Strategy for the Therapeutic Intervention of Human Astrocytoma and Medulloblastoma". In Understanding Biology Using Peptides, 453-454. Springer New York, 2006.
    Publicado • 10.1007/978-0-387-26575-9_192
  8. Jones, S; Howl, J. "Cell penetrating peptides as signal transduction modulators". In Handbook of cell-penetrating peptides, 273-291. CRC Press, 2006.
    Publicado
  9. Howl, John. "Chimerism: A strategy to expand the utility and applications of peptides". In Peptide Synthesis and Applications, 25-41. Humana Press, 2005.
    Publicado • 10.1385/1-59259-877-3:025
  10. Farquhar, Michelle; Soomets, Ursel; Martin, Ashley; Langel, Ülo; Howl, John. "Chimeric Mastoparans: Biological Probes and Designer Secretagogues". In Peptides: The Wave of the Future, 750-751. Springer Netherlands, 2002.
    Publicado • 10.1007/978-94-010-0464-0_350
  11. Slaninová, J.; Machová, A.; Kuncarová, P.; Malentinská, L.; Howl, John. "Receptor affinity and biological activity of chimeric peptides combining bradykinin with arginine vasopressin or fibronectin-related ‘RGD’ sequences". In 2nd Hellenic Forum on Bioactive Peptides, 359-365. 2001.
    Publicado
  12. Broown, J.; Brown, Colin A; Martin, A.; Langel, U.; Howl, John. "Peptide mimetics of receptor extracellular domains modulate signal transduction by P2Y2 receptors". In Peptides for the New Millennium, 594-596. Kluwer Academic Publisher, 2000.
    Publicado
  13. Wheatley, Mark. "Multifunctional chimeric analogs of small peptide hormones: Agonists and receptor-selective antagonists". In Peptides: Frontiers of Peptide Science, 601-602. Mayflower Scientific Ltd, 1999.
    Publicado
  14. Wheatley, Mark; Howl, John; Yarwood, Nicola J.; Davies, Andrew R. L.; Parslow, Rosemary A.. "Preparation of a Membrane Fraction for Receptor Studies and Solubilization of Receptor Proteins with Retention of Biological Activity". In Methods in Molecular Biology: Neuropeptide Protocols, 305-322. Humana Press, 1996.
    Publicado • 10.1385/0-89603-399-6:305
  15. Wheatley, M.. "Direct interaction of ligands with extracellular domains of neurohypophysial hormone receptors". In Peptides: Chemistry, Structure & Biology, 400-402. Mayflower Scientific Ltd, 1996.
    Publicado
  16. Howl, John; Wheatley, Mark. "V1a Vasopressin Receptors: Selective Biotinylated Probes". In Methods in Neurosciences, 281-296. Elsevier, 1993.
    Publicado • 10.1016/b978-0-12-185275-7.50022-6
Livro
  1. Howl, John; Jones, S.. Bioactive Peptides. CRC Press. 2009.
    Publicado
  2. Howl, John. Peptide Synthesis and Applications. Humana Press. 2005.
    Publicado
Resumo em conferência
  1. Howl, J.; Jones, S.. "Identification and biological applications of rhegnylogically-organised cell penetrating peptides". Trabalho apresentado em 4th International Peptide Symposium, 2007.
    Publicado • 10.1135/css201113004
  2. Jones, S.; Martel, C.; Belzacq-Casagrande, A.; Brenner, Catherine; Howl, John. "Mitoparans: mitochondriotoxic cell penetrating peptides and novel inducers of apoptosis". Trabalho apresentado em 4th International peptide Symposium, 2007.
    Publicado
  3. Howl, John. "Chimeric cell penetrating peptides as signal transduction modulators". Trabalho apresentado em Chemistry and Biology of Peptides, 2006.
    Publicado
  4. Mall, J.; Howl, John; Darling, J.. "Peptide-conjugated nanoparticles for tumour-selective imaging and drug delivery". Trabalho apresentado em 29th European Peptide Symposium, 2006.
    Publicado
  5. Jones, S; Ostlund, P; Langel, U.; Zorko, M.I.; Nicholl, I.; Howl, John. "A rhegnylogic strategy for the synthesis of signal transduction modulatory, cell penetrating peptides". Trabalho apresentado em 29th European Peptide Symposium, 2006.
    Publicado
  6. Howl, John; Farquhar, M.J.; Jones, S.. "Applications of cell-penetrating peptides as signal transduction modulators". Trabalho apresentado em Cell-penetrating Peptides and Applications, 2005.
    Publicado
  7. Howl, John; Farquhar, M. J.; Jones, S.. "Design, synthesis and applications of cell-penetrant peptides as signal transduction modulators". Trabalho apresentado em 19th American Peptide Symposium, 2005.
    Publicado
  8. Jones, S.; Howl, John. "Peptidyl-based delivery systems as a strategy for the therapeutic intervention of human astrocytoma and medulloblastoma". Trabalho apresentado em 19th American Peptide Symposium, 2005.
    Publicado
  9. Jones, S.; Howl, John. "Chimeric strategies for the delivery of cytotoxic peptides to astrocytoma". Trabalho apresentado em 28th European Peptide Symposium, 2004.
    Publicado
  10. Baker, R.; Howl, John; Nicholl, I.. "Sensitivity of human carcinoma cell lines to a cytotoxic cell penetrant mimetic of P21". Trabalho apresentado em 28th European Peptide Symposium, 2004.
    Publicado
  11. Howl, John; Jones, S.. "Amphiphilic peptide engineering: charge delocalization and the design of novel mastoparan analogues". Trabalho apresentado em 28th European Peptide Symposium, 2004.
    Publicado
  12. Baker, R.D.; Howl, John; Nicholl, I.. "Human glioblastoma cell lines, U373 MG and U251 MG, show sensitivity to a cytotoxic cell penetrant mimetic of p21". Trabalho apresentado em British Neuro-Oncology Society Annual Meeting, 2004.
    Publicado
  13. Jones, S.; Howl, John. "Chimeric strategies for the delivery of cytotoxic peptides to astrocytoma". Trabalho apresentado em British Neuro-Oncology Society Annual Meeting, 2004.
    Publicado
  14. Jones, S.; Howl, J.. "Amphiphilic peptide engineering: Rediscovering the wheel". Trabalho apresentado em British Neuro-Oncology Society Annual Meeting, 2004.
    Publicado
  15. Payne, S.J; Jones, S.; Farquhar, M.J.; Brown, C.A.; Alexander, B.; Howl, John. "Functional responses to neurohypophysial peptides and kinins in a novel endothelial cell line". Trabalho apresentado em Signalling the Future, Biochemistry Society, 2002.
    Publicado
  16. Jones, S; Howl, John. "Elucidation of CB1 mediated signal transduction using proteomics and peptidomimetic probes". Trabalho apresentado em Signalling the Future, Biochemistry Society, 2002.
    Publicado
  17. Jones, S.; Martin, A; Howl, John. "Elucidation of cannabinoid receptor (CB1)-mediated signal transduction pathways using proteomics and peptidomimetics". Trabalho apresentado em 3rd International Conference on Signal Transduction, 2002.
    Publicado
  18. Farquhar, M.J.; Soomets, U.; Martin, A.; Langel, U.; Howl, John. "Chimeric mastoparans: biological probes and designer secretagogues". Trabalho apresentado em 17th American peptide Symposium, 2001.
    Publicado
  19. Farquhar, M.J.; Soomets, U.; Bron, C.; Martin, A.; Bates, R.; Langel, U; Howl, John. "Venmus Chimeric Secretagogues". Trabalho apresentado em 26th European peptide Symposium, 2000.
    Publicado
  20. Brown, J.; Howl, John; Martin, A.; Soomets, U.; Langel, U. "Single amino-acid substitutions in a mimetic tetradecapeptide agonist of the human P2Y2 receptor prevent second messenger activation". Trabalho apresentado em 26th European peptide Symposium, 2000.
    Publicado
  21. Reading, S.; Jones, S.; Howl, John; Martin, A.; Alexander, B.; Benjamin, I.; Brown, C.. "Functional responses to kinins in a novel bovine hepatic artery endothelial cell line". Trabalho apresentado em 26th European peptide Symposium, 2000.
    Publicado
  22. Brown, J.; Brown, C.A.; Martin, A,; Langel, U.; Howl, John. "Peptide mimetics of receptor extracellular domains modulate signal transduction by P2Y2 receptors". Trabalho apresentado em 16th American Peptide Symposium, 1999.
    Publicado
  23. Howl, John. "Chimeric analogues of vasopressin and bradykinin". Trabalho apresentado em Bioactive Peptides VI, 1999.
    Publicado
  24. Howl, John. "Multifunctional chimeric analogs of small peptide hormones: Agonists and receptor-selective antagonists". Trabalho apresentado em 15th American Peptide Symposium, 1997.
    Publicado
  25. Yarwood, N.J; Howl, John; Wheatley, M.. "Selective biotinylated probes for oxytocin receptors". Trabalho apresentado em Peptide Receptors, 1996.
    Publicado
  26. Howl, John; Wheatley, M.. "Recognition of ligands by the V1a vasopressin receptor". Trabalho apresentado em 14th American Peptide Symposium, 1995.
    Publicado
  27. Howl, John. "Vasopressin receptors - Heterogeneity and homogeneity". Trabalho apresentado em Medical Research Society, 1994.
    Publicado
  28. Howl, John; Parslow, R.A.; Wheatley, M.. "Defining the ligand binding site of vasopressin receptors: a peptide mimetic approach". Trabalho apresentado em 652nd Biochemical Society Meeting, 1994.
  29. Howl, John; Wheatley, M. "Cyclic and linear heterofunctional V1a-selective vasopressin receptor ligands". Trabalho apresentado em Neurohypophysial Peptide Systems Symposium, 1993.
    Publicado
  30. Sermasi, E.; Howl, John; Wheatley, M.; Coote, J.H. "Electrophysiological and histochemical evidence for the presence of vasopressin V1a, but not oxytocin, receptors on sympathetic preganglionic neurones". Trabalho apresentado em 32nd International Congress of Physiological Sciences, 1993.
    Publicado
  31. Wheatley, M.; Howl, John; Davies, A. R. L.; Parslow, R.A.. "The study of neuropeptide receptors". Trabalho apresentado em 648th Biochemical Society Meeting, 1993.
    Publicado
  32. Howl, John; Wheatley, M.. "Molecular approaches to the study of vasopressin receptors". Trabalho apresentado em Twelfth Summer Symposium in Molecular Biology, 1993.
    Publicado
  33. Wheatley, M; Parslow, R.A.; Lavis, R.; Hughes, P.; Rudge, S.; Michell, R.H.; Kirk, C.J.; Howl, John. "Molecular biological and pharmacological characterisation of vasopressin receptor expression in rat testis peritubular myoid cells". Trabalho apresentado em Twelfth Summer Symposium in Molecular Biology, 1993.
    Publicado
  34. Wheatley, M; Howl, John. "A high affinity biotinylated vasopressin analogue". Trabalho apresentado em 20th FEBS Meeting, 1991.
    Publicado
  35. Howl, John; Wheatley, M. "Design and synthesis of bi-functional vasopressin ligands". Trabalho apresentado em Proc. 15th Int. Cong. Biochem, 1991.

Propriedade Intelectual

Patente
  1. Howl, John. 2018. "Peptides modulating sperm motility by modulating the phosphoprotein phosphatase 1 complex". Portugal.
  2. Howl, John. 2012. "Chimeric constructs between glioma-homing peptide and cell-penetrating peptides".
    Concedida/Emitida
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2019 - Atual Developing a new approach for PCa treatment: modulation of phosphoprotein phosphatase 1 complexes using bioportides
Coorientador
Universidade de Aveiro, Portugal
2015 - Atual The design and biomedical applications of bioactive cell penetrating peptides
Coorientador
University of Wolverhampton, Reino Unido
2016 - 2020 Bioportide technologies for the treatment of cancer
Orientador
Peptide Chemistry Department, Egipto
2012 - 2016 The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells
Coorientador
University of Wolverhampton, Reino Unido
2001 - 2005 Design Synthesis and Evaluation of Receptor Mimetic Peptides as Signal Transduction Modulators
Orientador
University of Wolverhampton, Reino Unido

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2019 - 2019 Chemistry and Biology of Peptides (2019 - 2019)
Conferência (Membro da Comissão Organizadora)
 University of Wolverhampton, Reino Unido
2018 - 2018 35th European Peptide Symposium (2018 - 2018)
Simpósio (Membro da Comissão Científica)
 University of Dublin Trinity College, Irlanda
2018 - 2018 Frontiers in the Delivery of Therapeutics (2018 - 2018)
Conferência (Membro da Comissão Científica)
 Tallinna Ülikooli Eesti Humanitaarinstituut, Estónia
2015 - 2015 3nd Annual International Conference on Pharmacology & Pharmaceutical Sciences (2015 - 2015)
Conferência (Membro da Comissão Organizadora)
 Navamindradhiraj University, Tailândia
2015 - 2015 11th Australian Peptide Symposium (2015 - 2015)
Simpósio (Membro da Comissão Científica)
2014 - 2014 2nd Annual International Conference on Pharmacology & Pharmaceutical Sciences (2014 - 2014)
Conferência (Membro da Comissão Científica)
 National University of Singapore, Singapura
2013 - 2013 Cell Penetrating Peptides: Design, Synthesis and Applications (2013 - 2013)
Outro (Presidente da Comissão Organizadora)
 The Royal Society, Reino Unido
2012 - 2012 Peptide Therapeutics (2012 - 2012)
Conferência (Presidente da Comissão Organizadora)
 Universidad de Lanzarote, Espanha
2011 - 2011 Peptide Vectors and Delivery of Therapeutics (2011 - 2011)
Conferência (Membro da Comissão Científica)
 Tartu Ülikool, Estónia
2011 - 2011 Peptide Development and Manufacturing (2011 - 2011)
Conferência (Membro da Comissão Organizadora)
 Humboldt-Universität zu Berlin, Alemanha
2008 - 2008 30th European Peptide Symposium - Homing peptides (2008 - 2008)
Simpósio (Membro da Comissão Científica)
 Università degli Studi di Firenze, Itália
2007/05 - 2007/05 Cell Penetrating Peptides, a Biochemical Society Focused Meeting (2007/05 - 2008/05)
Encontro (Presidente da Comissão Organizadora)
 University of Wolverhampton, Reino Unido
Distinções

Prémio

2018 Fellowship of the Higher Education Academy

Outra distinção

2010 European Peptide Society UK General Assembly Officer