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In recent years, my primary research focus has been neuroimmunology, specifically exploring the intricate interplay between the immune system, neuropsychiatric disorders, and cognitive function. To gain deeper insights into the etiology of psychiatric conditions, immune disorders, and cognitive function, I am actively engaged in research projects investigating factors influencing fetal and infant development, including iodine supplementation and microbiome alterations. Utilizing human samples and animal models, I aim to contribute to our understanding of these complex relationships. Currently, I am doing my General Medicine internship (Unidade Local de Saúde de Coimbra). Over the past four years, I have served as a Junior Researcher at the Life and Health Sciences Research Institute, University of Minho. My academic background includes a degree in Biochemistry, a Master's in Clinical Immunology, a PhD in Health Sciences, and an Integrated Master's in Medicine. Throughout my research journey, I have actively participated in 15 projects, resulting in 41 publications, where I held the first authorship in 9. These publications collectively boast a cumulative impact factor of 196, with 1052 citations and an H-index 16 (update in January 2024 on Web of Science).
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Identificação

Identificação pessoal

Nome completo
SUSANA CRISTINA ROQUE DE OLIVEIRA

Identificadores de autor

Ciência ID
9C1A-90D1-18C9
ORCID iD
0000-0002-6512-996X
Researcher Id
F-1400-2010
Scopus Author Id
23029107200
Formação
Grau Classificação
2022/09
Concluído
 Medicina (Mestrado integrado)
Universidade do Porto Faculdade de Medicina, Portugal
2011
Concluído
 PhD in Health Sciences (Doutoramento)
Universidade do Minho Escola de Medicina, Portugal
"INFECTION AND MOOD DISORDERS: A BIDIRECTIONAL INTERACTION?" (TESE/DISSERTAÇÃO)
 Unanimously Approved
2007
Concluído
 Clinical Immunology (Mestrado)
Universidade da Beira Interior, Portugal
"Interleukin-10 production underlies distinct susceptibility of BALB/c and C57BL/6 mice to Mycobacterium avium infection and influences efficacy of antibiotic therapy" (TESE/DISSERTAÇÃO)
 Muito Bom
2003
Concluído
 Bioquímica (Licenciatura)
Universidade da Beira Interior, Portugal
"Study of the cytokine profile of peripheral blood mononuclear cells short-term primary cultures, from patients with house dust mite allergy." (TESE/DISSERTAÇÃO)
 15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/08/01 - Atual Investigador Contratado (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018/01 - 2019/07/31 Investigador Auxiliar (carreira) (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2011/06/01 - 2017/09/30 Pós-doutorado (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2006/02 - 2006/06 Assistente Convidado (Docente Universitário) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2006/11/01 - 2011/05/09 PhD Student with a FCT fellowship in the research project: Infection and Mood disorders: A bidirectional interaction? Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2006/01/01 - 2006/10/01 Fellowship researcher in the research project: Characterization of the iodine status of Portuguese women in fertile age and its relation with the psychomotor performance of the newborn Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2004/04/01 - 2006/10/01 Master student in the research project: Manipulation of interleukin-10 activity to improve the efficacy of antimycobacterial therapy. Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2002/09/01 - 2003/08/01 Scientific trainee as part of the Biochemistry Degree in the research project: Study of the cytokine profile of peripheral blood mononuclear cells short-term primary cultures, from patients with house Universidade da Beira Interior, Portugal
Projetos

Bolsa

Designação Financiadores
2023/01/02 - Atual Sorting out the interplay between stress and the proteostasis regulator SNX27 on the reward circuit
2022.04850.PTDC
Team member
Fundação para a Ciência e a Tecnologia
2011 - 2017 Interleukin-10 as a modulator of the hypothalamic-pituitary-adrenal axis in depression and cognition
SFRH/BPD/72710/2010
SFRH/BPD/72710/2010
Bolseiro de Pós-Doutoramento
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 N/A
Concluído
2006 - 2011 Infection and Mood disorders: A bidirectional interaction?
SFRH/BD/24539/2005
Bolseiro de Doutoramento
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Concluído

Projeto

Designação Financiadores
2018 - Atual Assessing the effectiveness of iodine supplementation in preconception, pregnancy and lactation, on the mother and newborn’s endocrine status and on the child’s psychomotor development
na
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Em curso
2016 - Atual Role of IL10 in depression and cognition
na
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Em curso
2021/01/01 - 2025/12/31 ICVS/3B¿s - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos
LA/P/0050/2020
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2019/08/01 - 2025/07/31 Identification of new immunomodulators: the next generation of antidepressant therapy
DL 57/2016/CP1377/CT0128
10.54499/DL57/2016/CP1377/CT0128
Outra
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2020 - 2023 SARS-CoV-2 phenotypes of infection: integrated analysis of a longitudinal cohort to generate a prognostic predictive model
Research4COVID19 - 441
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2020/04/27 - 2020/07/27 Which, when and for who? Serodiagnosis as a tool to complement diagnosis and evaluate population immunity against SARS-CoV-2
596694995
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Em curso
2017 - 2020 A novel multimodal predictive approach of the effects of antidepressants in the recovery, remission and relapse of depression (participation as a team member analysing the immune system of the patients with depression).
n/a
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Concluído
2019/01/01 - 2019/12/31 ICVS/3B¿s - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group
UID/Multi/50026/2019
Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2015/10 - 2018/09 Impact of a novel vaccine candidate against Group B Streptococcus-induced neonatal diseases on commensal microbiota
Provided by PTCRIS: 139674
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Institut Pasteur, França
Fundação para a Ciência e a Tecnologia, I.P.
Concluído
2016 - 2018 Studies on thoracic and peritoneal CO2-insufflation in neonatal rats: implications for minimally invasive neonatal surgery (participation as a team member).
na
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014/03 - 2015/08 Multiple Sclerosis: Studying lipocalin 2 as a novel player in the pathophysiology of the disease.
Provided by PTCRIS: 135221
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
2010/03 - 2013/02 Multimodal analysis of the neurobiology of depression
Provided by PTCRIS: 105180
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
2007/07 - 2010/06 New perspectives in the neurobiology of depression: beyond the “neurochemical hypothesis”
Provided by PTCRIS: 72699
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
2004/10 - 2005/09 Manipulation of interleukin-10 activity to improve the efficacy of antimycobacterial therapy
Provided by PTCRIS: 45491
Investigador
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Fundação para a Ciência e a Tecnologia, I.P.
Produções

Publicações

Artigo em revista
  1. Joana Ferreira; Adhemar Longatto-Filho; Julieta Afonso; Susana Roque; Alexandre Lima Carneiro; Isabel Vila; Cristina Silva; et al. "Inflammatory Cells in Adipose Tissue and Skeletal Muscle of Patients with Peripheral Arterial Disease or Chronic Venous Disease: A Prospective, Observational, and Histological Study". Journal of Cardiovascular Development and Disease (2024): https://doi.org/10.3390/jcdd11040121.
    10.3390/jcdd11040121
  2. Maria José Costeira; Patrício Costa; Susana Roque; Ivone Carvalho; Laura Vilarinho; Joana Almeida Palha. "History of Neonatal Screening of Congenital Hypothyroidism in Portugal". International Journal of Neonatal Screening (2024): https://doi.org/10.3390/ijns10010016.
    10.3390/ijns10010016
  3. Joana Ferreira; Julieta Afonso; Adhemar Longatto-Filho; Susana Roque; Alexandre Carneiro; Isabel Vila; Cristina Silva; et al. "Inflammation Is a Histological Characteristic of Skeletal Muscle in Chronic Limb Threatening Ischemia". Annals of Vascular Surgery (2024): https://doi.org/10.1016/j.avsg.2023.09.094.
    10.1016/j.avsg.2023.09.094
  4. Joana Almeida Palha; Maria Lopes-Pereira; Susana Roque; Sarai Isabel Machado; Tim I M Korevaar; Anna Quialheiro; Ana Machado; et al. "IODINEMINHO STUDY: IODINE SUPPLEMENTATION AND PREVALENCE OF IODINE DEFICIENCY IN PREGNANT WOMEN". J Clinical Endocrinology and Metabolism (2024): https://doi.org/10.1210/clinem/dgae041.
    No prelo • 10.1210/clinem/dgae041
  5. Joana Ferreira; Julieta Afonso; Alexandre Lima Carneiro; Isabel Vila; Cristina Cunha; Susana Roque; Cristina Silva; et al. "Exploring the Diversity of Visceral, Subcutaneous and Perivascular Adipose Tissue in a Vascular Surgery Population". Journal of Cardiovascular Development and Disease (2023): https://doi.org/10.3390/jcdd10070271.
    10.3390/jcdd10070271
  6. Roque S; de Sá-Calçada D; Cerqueira-Rodrigues B; Susana Monteiro; Guerreiro SG; Palha JA; Correia-Neves M. "Chronic Mycobacterium avium infection differentially affects the cytokine expression profile of three mouse strains, but has no effect on behavior.". Scientific reports (2023): https://europepmc.org/articles/PMC10110542.
    10.1038/s41598-023-33121-2
  7. Sarai Isabel Machado; Maria Lopes Pereira; Susana Roque; Maria José Costeira; Adriano A. Bordalo; André Miranda; Patrício Costa; Nuno Borges; Joana Almeida Palha. "Iodine Availability through Iodized Salt in Portugal: 2010–2021 Sales Evolution and Distribution". Nutrients (2023): https://doi.org/10.3390/nu15061324.
    10.3390/nu15061324
  8. Bevilacqua Rolfsen Ferreira da Silva, Gisela; Pereira das Neves, Sofia; Roque Oliveira, Susana Cristina; Marques, Fernanda; Gomes de Oliveira, Anselmo; de Lima Leite, Fábio; Cerqueira, João José. "Comparative effectiveness of preventive treatment with dimethyl fumarate-loaded solid lipid nanoparticles and oral dimethyl fumarate in a mouse model of multiple sclerosis". Journal of Autoimmunity 132 (2022): 102893. http://dx.doi.org/10.1016/j.jaut.2022.102893.
    10.1016/j.jaut.2022.102893
  9. Bonifácio Andrade, Elva; Lorga, Inês; Roque, Susana; Geraldo, Rafaela; Mesquita, Pedro; Castro, Rogério; Simões-Costa, Luísa; et al. "Maternal vaccination against group B Streptococcus glyceraldehyde-3-phosphate dehydrogenase leads to gut dysbiosis in the offspring". Brain, Behavior, and Immunity 103 (2022): 186-201. http://dx.doi.org/10.1016/j.bbi.2022.04.004.
    10.1016/j.bbi.2022.04.004
  10. Gallo, Valentina; Reis, Ana; Miranda, André; Martins, Carolina; Serre-Miranda, Cláudia; Nobrega, Claudia; Silva, Carolina S.; et al. "Increased Gal-3BP plasma levels in hospitalized patients infected with SARS-CoV-2". Clinical and Experimental Medicine (2022): http://dx.doi.org/10.1007/s10238-021-00788-8.
    10.1007/s10238-021-00788-8
  11. Lopes Pereira Maria; Abreu, Anna Quialheiro; Costa, Patrício; Susana Roque; Correia, Nadine; Correia-Neves, Margarida; Goios, Ana; et al. Autor correspondente: Palha, Joana Almeida. "Iodine supplementation: compliance and association with adverse obstetric and neonatal outcomes". European Thyroid Journal (2022): https://etj.bioscientifica.com/view/journals/etj/aop/etj-21-0035/etj-21-0035.xml.
  12. Serre-Miranda, Cláudia ; Susana Roque; Barreira-Silva, Palmira; Nobrega, Claudia; Vieira, Neide; Costa, Patrício; Palha, Joana Almeida; Correia-Neves, Margarida. "Age-related sexual dimorphism on the longitudinal progression of blood immune cells in BALB/cByJ mice.". The journals of gerontology. Series A, Biological sciences and medical sciences (2021): https://doi.org/10.1093/gerona/glab330.
    10.1093/gerona/glab330
  13. Lopes-Pereira, Maria; Roque, Susana; Costa, Patrício; Quialheiro, Anna; Santos, Nadine Correia; Goios, Ana; Vilarinho, Laura; Correia-Neves, Margarida; Palha, Joana Almeida. "Impact of iodine supplementation during preconception, pregnancy and lactation on maternal thyroid homeostasis and offspring psychomotor development: protocol of the IodineMinho prospective study". BMC Pregnancy and Childbirth 20 1 (2020): http://dx.doi.org/10.1186/s12884-020-03376-y.
    10.1186/s12884-020-03376-y
  14. Serre-Miranda, Cláudia; Roque, Susana; Santos, Nadine Correia; Costa, Patrício; Sousa, Nuno; Palha, Joana Almeida; Correia-Neves, Margarida. "Cognition Is Associated With Peripheral Immune Molecules in Healthy Older Adults: A Cross-Sectional Study". Frontiers in Immunology 11 (2020): http://dx.doi.org/10.3389/fimmu.2020.02045.
    10.3389/fimmu.2020.02045
  15. Miranda, Alice; Roque, Susana; Serre-Miranda, Cláudia; Pêgo, José Miguel; Correia-Pinto, Jorge. "Inflammatory response and long-term behavioral assessment after neonatal CO 2 -pneumothorax: study in a rodent model". Journal of Pediatric Surgery 53 7 (2018): 1318-1325. http://dx.doi.org/10.1016/j.jpedsurg.2017.08.016.
    10.1016/j.jpedsurg.2017.08.016
  16. Miranda, Alice; Roque, Susana; Pêgo, José M.; Correia-Pinto, Jorge. "Neurodevelopment impact of CO 2 -pneumoperitoneum in neonates: experimental study in a rat model". Journal of Surgical Research 221 (2018): 293-303. http://dx.doi.org/10.1016/j.jss.2017.09.014.
    10.1016/j.jss.2017.09.014
  17. Das Neves, S.P.; Serre-Miranda, C.; Nobrega, C.; Roque, S.; Cerqueira, J.J.; Correia-Neves, M.; Marques, F.. "Immune thymic profile of the MOG-induced experimental autoimmune encephalomyelitis mouse model". Frontiers in Immunology 9 OCT (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85055341963&partnerID=MN8TOARS.
    10.3389/fimmu.2018.02335
  18. Monteiro S; Roque S; Marques F; Correia-Neves M; Cerqueira JJ. "Brain interference: revisiting the role of IFN¿ in the central nervous system.". (2017): http://europepmc.org/abstract/med/28528956.
    10.1016/j.pneurobio.2017.05.003
  19. Ashley Novais*; Susana Roque*; Susana Monteiro*; Margarida Correia-Neves; Nuno Sousa. "How age, sex and genotype shape the stress response". Neurobiology of Stress 6 (2017): 44-56. https://doi.org/10.1016%2Fj.ynstr.2016.11.004.
    10.1016/j.ynstr.2016.11.004
  20. Lobo-Silva, D.; Carriche, G.M.; Castro, A.G.; Roque, S.; Saraiva, M.; Lobo-Silva D; Carriche GM; et al. "Interferon-ß regulates the production of IL-10 by toll-like receptor-activated microglia". GLIA 65 9 (2017): 1439-1451. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021258982&partnerID=MN8TOARS.
    10.1002/glia.23172
  21. S Monteiro; F M Ferreira; V Pinto; S Roque; M Morais; D de Sá-Calçada; C Mota; M Correia-Neves; J J Cerqueira. "Absence of IFN¿ promotes hippocampal plasticity and enhances cognitive performance". Translational Psychiatry 6 1 (2016): e707-e707. https://doi.org/10.1038/tp.2015.194.
    10.1038/tp.2015.194
  22. Lobo-Silva, D.; Carriche, G.M.; Castro, A.G.; Roque, S.; Saraiva, M.; Lobo-Silva D; Carriche GM; et al. "Balancing the immune response in the brain: IL-10 and its regulation". Journal of Neuroinflammation 13 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84997106994&partnerID=MN8TOARS.
    10.1186/s12974-016-0763-8
  23. Serre-Miranda C*; Roque S*; Santos NC; Portugal-Nunes C; Costa P; Palha JA; Sousa N; Correia-Neves M. "Effector memory CD4(+) T cells are associated with cognitive performance in a senior population.". (2015): http://europepmc.org/abstract/med/25566544.
    10.1212/NXI.0000000000000054
  24. Monteiro, S.; Roque, S.; de Sá-Calçada, D.; Sousa, N.; Correia-Neves, M.; Cerqueira, J.J.. "An efficient chronic unpredictable stress protocol to induce stress-related responses in C57BL/6 mice". Frontiers in Psychiatry 6 FEB (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84926682006&partnerID=MN8TOARS.
    10.3389/fpsyt.2015.00006
  25. de Sá-Calçada D*; Roque S*; Branco C; Monteiro S; Cerqueira-Rodrigues B; Sousa N; Palha JA; Correia-Neves M. "Exploring Female Mice Interstrain Differences Relevant for Models of Depression.". (2015): http://europepmc.org/abstract/med/26696854.
    10.3389/fnbeh.2015.00335
  26. Cláudia Miranda; Susana Roque; Nadine Santos; Carlos Portugal-nunes; Patrício Costa; Joana Palha; Nuno Sousa; Margarida Correia-neves. "Cognitive performance among older individuals associated with the peripheral effector memory CD4+ T cells". Journal of Neuroimmunology 275 1-2 (2014): 203-203. http://dx.doi.org/10.1016/j.jneuroim.2014.08.545.
    10.1016/j.jneuroim.2014.08.545
  27. Roque, S.; Mesquita, A.R.; Palha, J.A.; Sousa, N.; Correia-Neves, M.. "The behavioral and immunological impact of maternal separation: A matter of timing". Frontiers in Behavioral Neuroscience 8 MAY (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84901460930&partnerID=MN8TOARS.
    10.3389/fnbeh.2014.00192
  28. Nobrega, C.; Cláudio Nunes-Alves; Cerqueira-Rodrigues, B.; Roque, S.; Barreira-Silva, P.; Behar, S.M.; Correia-Neves, M.. "T cells home to the thymus and control infection". Journal of Immunology 190 4 (2013): 1646-1658. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873543205&partnerID=MN8TOARS.
    10.4049/jimmunol.1202412
  29. Duarte, R.; Afonso, A.; Ferreira, C.; Roque, S.; Vasconcelos, O.; Sarmento-Castro, R.; Tavares, M.; et al. "A case-control study on the diagnostic potential of multi-antigen serological tests for tuberculosis". Archives of Clinical Microbiology 3 2 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84872006782&partnerID=MN8TOARS.
    10.3823/249
  30. Pereira, V.H.; Salgado, A.J.; Oliveira, J.M.; Cerqueira, S.R.; Frias, A.M.; Fraga, J.S.; Roque, S.; et al. "In vivo biodistribution of carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles in rats". Journal of Bioactive and Compatible Polymers 26 6 (2011): 619-627. http://www.scopus.com/inward/record.url?eid=2-s2.0-81555220089&partnerID=MN8TOARS.
    10.1177/0883911511425567
  31. Roque, S.; Oliveira, T.G.; Nobrega, C.; Barreira-Silva, P.; Nunes-Alves, C.; Sousa, N.; Palha, J.A.; Correia-Neves, M.. "Interplay between depressive-like behavior and the immune system in an animal model of prenatal dexamethasone administration". Frontiers in Behavioral Neuroscience FEBRUARY (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-84855237730&partnerID=MN8TOARS.
    10.3389/fnbeh.2011.00004
  32. Costeira, M.J.; Oliveira, P.; Ares, S.; Roque, S.; De Escobar, G.M.; Palha, J.A.. "Parameters of thyroid function throughout and after pregnancy in an iodine-deficient population". Thyroid 20 9 (2010): 995-1001. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956582669&partnerID=MN8TOARS.
    10.1089/thy.2009.0356
  33. Olsson, I.A.S.; Costa, A.; Nobrega, C.; Roque, S.; Correia-Neves, M.. "Environmental enrichment does not compromise the immune response in mice chronically infected with mycobacterium avium". Scandinavian Journal of Immunology 71 4 (2010): 249-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950019243&partnerID=MN8TOARS.
    10.1111/j.1365-3083.2010.02371.x
  34. Nobrega, C.; Roque, S.; Nunes-Alves, C.; Coelho, A.; Medeiros, I.; Castro, A.G.; Appelberg, R.; Correia-Neves, M.. "Dissemination of mycobacteria to the thymus renders newly generated T cells tolerant to the invading pathogen". Journal of Immunology 184 1 (2010): 351-358. http://www.scopus.com/inward/record.url?eid=2-s2.0-73949157248&partnerID=MN8TOARS.
    10.4049/jimmunol.0902152
  35. Roque, S.; Correia-Neves, M.; Mesquita, A. R.; Palha, J. A.; Sousa, N.. "Interleukin-10: a key cytokine in depression?". Cardiovasc Psychiatry Neurol 2009 (2009): 187894-187894.
    10.1155/2009/187894
  36. Margarida, Correia-Neves. "Mice chronically infected with mycobacterium avium show no signs of depressive/anxiety-like behaviour". Frontiers in Neuroscience 3 (2009): http://dx.doi.org/10.3389/conf.neuro.01.2009.11.036.
    10.3389/conf.neuro.01.2009.11.036
  37. Mesquita, A.R.; Correia-Neves, M.; Roque, S.; Castro, A.G.; Vieira, P.; Pedrosa, J.; Palha, J.A.; Sousa, N.. "IL-10 modulates depressive-like behavior". Journal of Psychiatric Research 43 2 (2008): 89-97. http://www.scopus.com/inward/record.url?eid=2-s2.0-45849117677&partnerID=MN8TOARS.
    10.1016/j.jpsychires.2008.02.004
  38. Roque S; Nobrega C; Appelberg R; Correia-Neves M. "IL-10 underlies distinct susceptibility of BALB/c and C57BL/6 mice to Mycobacterium avium infection and influences efficacy of antibiotic therapy.". (2007): http://europepmc.org/abstract/med/17548640.
    10.4049/jimmunol.178.12.8028
  39. Nobrega, C.; Cardona, P.-J.; Roque, S.; Pinto do Ó, P.; Appelberg, R.; Correia-Neves, M.. "The thymus as a target for mycobacterial infections". Microbes and Infection 9 14-15 (2007): 1521-1529. http://www.scopus.com/inward/record.url?eid=2-s2.0-36749031173&partnerID=MN8TOARS.
    10.1016/j.micinf.2007.08.006
Poster em conferência
  1. Neide Vieira; Ana Margarida Cunha; Marco Rafael Guimarães; Susana Roque; Claúdia Miranda; Wanjin Hong; Armando Almeida; Margarida Correia-Neves; Hugo Leite-Almeida. "Exploring Sorting Nexin 27 role in Pain". Trabalho apresentado em 15th Neuroscience Portuguese Society meeting, 2017.
Pré-impressão
  1. Joana Ferreira; Susana Roque; Alexandre Lima Carneiro; Adhemar Longatto-Filho; Isabel Vila; Cristina Cunha; Cristina Silva; et al. "Reversion of the inflammatory markers in patients with chronic limb threatening ischaemia". 2023. https://doi.org/10.1101/2023.07.25.23293181.
    10.1101/2023.07.25.23293181

Outros

Outra produção
  1. IFN¿ and iNOS-mediated alterations in the bone marrow and thymus and its impact on Mycobacterium avium-induced thymic atrophy. 2021. Palmira Barreira-Silva; Rita Melo-Miranda; Claudia Nobrega; Susana Roque; Cláudia Serre-Miranda; Margarida Borges; Daniela de Sá Calçada; et al. https://doi.org/10.1101/2021.02.23.432464.
    10.1101/2021.02.23.432464
  2. Performance assessment of 11 commercial serological tests for SARS-CoV-2 on hospitalized COVID-19 patients. International Journal of Infectious Diseases. 2020. C Serre-Miranda; C Nobrega; S Roque; J Canto-Gomes; CS Silva; N Vieira; P Barreira-Silva; et al. https://doi.org/10.1101/2020.08.06.20168856.
    10.1101/2020.08.06.20168856
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2015 Serre-Miranda, Claudia; Roque, Susana; Santos, Nadine C; Portugal-Nunes, Carlos; Costa, Patricio; Palha, Joana A; Sousa, Nuno; Correia-Neves, Margarida. Effector memory CD4+ T cells are associated with cognitive performance in a senior population. (Oral Presentation ) 29º Reunião do Grupo de Estudos de Envelhecimento Cerebral e Demencia
2013 Teles, Diogo; Calçada, Daniela; Sousa, Nuno; Palha, Joana A.; Correia-Neves, Margarida; Roque, Susana; “IL-10: A key molecule in antidepressant therapy resistance". (Oral Communication) Fundação Astrazeneca Innovate Competition, an initiative included in iMed 5.0 Conference, Lisbon
2013 Miranda, Cláudia; Santos, Nadine; Sousa, Nuno; Correia-Neves, Margarida; Roque, Susana. “Can distinct cognitive performances among aged individuals be related with distinct immune system profiles?”. (Oral Comunication). Portuguese Society of Neurocience Meeting, 30 May – 1 June 2013, Luso
2011 Teles, Diogo; Monteiro, Susana; Quintas, Filipe; Rodrigues, Bruno; Calçada, Daniela; Sousa, Nuno; Palha, Joana A.; Correia-Neves, Margarida; Roque, Susana. “IL-10 plays a role in the several behavioral dimensions of depression”. (Oral communication) VI YES Meeting, 16-18 September 2011, Porto
2011 Quintas, Filipe; Monteiro, Susana; Branco, Carlos; Sousa, Nuno; Palha, Joana A.; Correia-Neves, Margarida; Roque, Susana. IL-10 is a key molecule in different behavioral domains present in depression. (Oral communication).
Leiden International Medical Students' Conference (LIMSC), Leiden, 16-20 March 2011
2008 Roque, Susana; Oliveira, Tiago G; Leão, Pedro; Oliveira, Mário; Palha, Joana A; Sousa, Nuno; Correia-Neves, Margarida. Antenatal dexamethasone administration induces alteration of the immune system in adulthood, (Oral communication). XXXIV Annual Meeting of the Portuguese Society for Immunology, September 26-28, Porto
2007 Roque, Susana; Nobrega, Claudia; Palha, Joana A; Sousa, Nuno; Correia-Neves, Margarida. Mice chronically infected with Mycobacterium avium show no signs of depressive/anxiety-like behavior (oral communication) Workshop Drug Treatment of Psychiatric and Neurological Disorders, November 26-29, Cologne

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2020 - 2021 Characterization of the mechanisms underlying behavioral alterations in interleukin-10 KO mice
Orientador de Sónia Gomes
 Master program in Health Sciences (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2019 - 2021 Deciphering the mechanisms underlying the role of interleukin-10 in cognitive function
Orientador de Rogério Cristiano Rocha de Castro
 Master program in Health Sciences (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
2018 - 2018 Cognitive performance: exploring the role of Interleukin -10 in male mice
Orientador de Ângela Sofia Gerós Mesquita
 Master in Health Sciences (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
2018 - 2018 The role of IL-10 in cognition
Orientador de Rogério Castro
 Bioquímica (Licenciatura/Bacharelato)
Universidade do Minho, Portugal
2017 - 2017 Dissecting SNX27 role in the Brain: Implications for cognition
Coorientador de Liliana Ferreira
 Master in Health Sciences (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
2016 - 2016 Behavioral characterization of C57BL/6 TCR-alpha knock-out mice.
Orientador de João Pacheco
 Integrated Master in Medicine (Outra)
Universidade do Minho Escola de Medicina, Portugal
2015 - 2015 The role of IL-10 in cognitive, anxious, depressive-like behaviors in C57BL/6 mice.
Orientador de Sofia Oliveira
 Bioquímica (Licenciatura/Bacharelato)
Universidade do Minho, Portugal
2012 - 2012 Could the immunosenescence profile among aged individuals be related with their distinct cognitive performances?
Orientador de Cláudia Miranda
 Master in Health Sciences (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
2012 - 2012 Towards the molecular understanding of BACE-1 and Aß physiological role in thymus differentiation and function
Coorientador de Ana Claudia Ribeiro
 Master in Health Sciences (Mestrado)
Universidade do Minho Escola de Medicina, Portugal
2012 - 2012 Aged and healthy brain: a study of the relation between cognitive decline and the immunosenescence profile
Orientador de José Gomes
 Bioquímica (Licenciatura/Bacharelato)
Universidade do Minho, Portugal
2010 - 2010 The role of anti-inflammatory cytokines in cognitive behaviors
Orientador de Filipe Quintas
 Integrated Master in Medicine (Outra)
Universidade do Minho Escola de Medicina, Portugal
2010 - 2010 Behavior Disorders in CD1 Mice Chronically Infected with Mycobacterium avium
Orientador de Carlos Branco
 Integrated Master in Medicine (Outra)
Universidade do Minho Escola de Medicina, Portugal

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2020 - 2020 This course was given by Rosaria Galanti (Karolinska Institute)) Attendee (20-hours course)
Seminário
 Outcome evaluation of public health interventions
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018 - 2018 This course covered advanced flow cytometry topics . Atendee (18-hours course)
Oficina (workshop)
 2nd FLxFlow Course (Advanced Module)
Instituto Gulbenkian de Ciência, Portugal
2017 - 2017 Serre-Miranda, Cláudia; Sá-Calçada, Daniela; Monteiro, Susana; Sousa, Nuno; Palha, Joana A; Correia-Neves, Margarida; Roque, Susana. The lack of the anti-inflammatory interleukin 10 (IL 10) leads to cognitive impairment. (Poster)
Congresso
 XV Meeting of the Portuguese Society for Neurosciences, Braga.
2015 - 2015 Roque, Susana; de-Sá Calçada, Daniela; Serre-Miranda, Claudia; Rodrigues-Cerqueira, Bruno; Monteiro, Susana; Teles, Diogo; Branco, Carlos; Sousa, Nuno; Palha, Joana A; Correia-Neves, Margarida. The role of IL10 in depression and antidepressant therapy. (Poster)
Congresso
 XIV Meeting of the Portuguese Society for Neurosciences, Póvoa do Varzim
2013 - 2013 Roque, Susana; Calçada, Daniela; Monteiro, Susana; Branco, Carlos; Cerqueira-Rodrigues, Bruno; Palha, Joana A; Sousa, Nuno; Correia-Neves, Margarida. “Mycobacterium avium chronic infection induces alterations in the hippocampal cytokine profile”. (poster)
Congresso
 Portuguese Society of Neurocience Meeting, 30 May – 1 June 2013, Luso
2012 - 2012 post-graduation course. attendee (14 hours).
Oficina (workshop)
 Obesity and metabolic syndrome: an update
Universidade do Minho Escola de Medicina, Portugal
2011 - 2011 Roque, Susana; Rodrigues, Bruno; Monteiro, Susana; Branco, Carlos; Sousa, Nuno; Palha, Joana A; Correia-Neves, Margarida. “The effect of Mycobacterium avium chronic infection on depressive-like behavior is dependent on the mouse genetic background”. (Poster).
Congresso
 8th IBRO World Congress of Neuroscience: July 14-18, 2011, Florence.
2011 - 2011 Roque, Susana; Rodrigues, Bruno; Monteiro, Susana; Branco, Carlos; Sousa, Nuno; Palha, Joana A; Correia-Neves, Margarida. “Behavioral alterations caused by Mycobacterium avium chronic infection are mouse strain dependent. (Poster).
Congresso
 PNI Mechanisms of Disease: From Pathophysiology to Prevention and Treatment”. 18th Annual PNIRS Meeting: June 8-11, 2011, Chicago.
2010 - 2010 Roque, Susana; Rodrigues, Bruno; Monteiro, Susana; Nobrega, Claudia; Sousa, Nuno; Palha, Joana A; Correia-Neves, Margarida. Can peripheral chronic infection with Mycobacterium avium induce alterations in brain cytokine profile?,(Poster)
Congresso
 2nd International conference on neuroinfection and worldwide impact, 2-6t December 2010, Saint-Denis, Reunion Island
2010 - 2010 Branco, Carlos; Quintas, Filipe; Monteiro, Susana; Correia-Neves, Margarida; Roque, Susana. Chronic Mycobacterium avium infection reduces depressive-like behavior and improves cognitive performance of CD1 mice. (Poster)
Congresso
 XV JOCEM, organized by the National Association of Medical Students (ANEM), 19-21 November
2010 - 2010 Branco, Carlos; Quintas, Filipe; Monteiro, Susana; Correia-Neves, Margarida; Roque, Susana. Behavior Disorders in CD1 Mice Chronically Infected with Mycobacterium avium, (Poster).
Congresso
 V YES Meeting, 24-26 September, Porto
2010 - 2010 Roque, Susana; Oliveira, Tiago G; Nobrega, Claudia; Barreira-Silva, Palmira; Nunes-Alves, Cláudio; Sousa, Nuno; Palha, Joana A; Correia-Neves, Margarida. Depressive-like behavior in adult prenatally dexamethasone administered rats is accompanied by alterations in the immune system, (Poster
Congresso
 XXXVI Annual Meeting of the Portuguese Society for Immunology, 20-22 September, Braga
2009 - 2009 Roque, Susana; Nobrega, Claudia; Nunes-Alves, Cláudio; Sousa, Nuno; Palha, Joana A; Correia-Neves, Margarida. Chronic infection with Mycobacterium avium does not induce depressive-like behavior (Poster)
Congresso
 Neuroscience 2009, Society for Neuroscience's 39th annual meeting, Chicago
2009 - 2009 Roque, Susana; Nobrega, Claudia; Nunes-Alves, Cláudio; Palha, Joana A; Sousa, Nuno; Correia-Neves, Margarida. Does chronic infection increase vulnerability to mood disorder s induced by stress? (Poster).
Congresso
 Workshop Drugs and the Brain: an update in Psychopharmacology, February 9-13, Braga
2009 - 2009 Roque, Susana; Nobrega, Claudia; Nunes-Alves, Cláudio; Sousa, Nuno; Palha, Joana A; Correia-Neves, Margarida. Mice chronically infected with Mycobacterium avium show no signs of depressive/anxiety-like behavior, (Poster)
Congresso
 11th Meeting of the Portuguese Society for Neurosciences, 3-6 June, Braga
2009 - 2009 Post-graduation course. Attendee (35 hours)
Oficina (workshop)
 Fundamentals in Neurosciences: Morphological and Behavioral Approaches
Universidade do Minho Escola de Medicina, Portugal
2009 - 2009 Post-graduation course. Attendee (35 hours)
Oficina (workshop)
 Workshop Drugs and the Brain: an update in Psychopharmacology, European Graduate School of Neuroscience
2008 - 2008 Post-graduation course. Attendee (21 hours)
Oficina (workshop)
 Immunoregulation in Infectious Diseases: from immunity to bugs and back
Universidade do Minho Escola de Medicina, Portugal
2008 - 2008 Post-graduation course. Attendee (70 hours) - Certified by the Portuguese national authority for animal experimentation (DGAV) in 2011 as coordinator researcher.
Oficina (workshop)
 Laboratory Animal Science, 4th edition
Universidade do Minho Escola de Medicina, Portugal
2006 - 2006 Roque, Susana; Nobrega, Claudia; Appelberg, Rui; Correia-Neves, Margarida. Different IL-10 and IFN-gamma production underlies distinct susceptibilities of Balb/c and C57BL/6 mice to Mycobacterium avium, (Poster)
Congresso
 XXXII Annual Meeting of the Portuguese Society for Immunology, October 13-14, Braga
2005 - 2005 Roque, Susana; Nobrega, Claudia; Appelberg, Rui; Correia-Neves, Margarida. Distinct IL-10 production underlies differences in susceptibility to Mycobacterium avium infection, (Poster).
Congresso
 XXXI Annual Meeting of the Portuguese Society for Immunology, November 25-26, Lisbon
2005 - 2005 Roque, Susana; Nobrega, Claudia; Appelberg, Rui; Correia-Neves, Margarida. Improvement of antimycobacterial therapy due to IL-10 activity blockage is strain dependent (Poster).
Congresso
 FOCIS 5th Annual Meeting, May 12-16, Boston

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2018 - 2018 Frontiers in Behavioral Neuroscience (1662-5153) Frontiers Media SA
2015 - 2015 Physiology & Behavior (0031-9384) Elsevier
2015 - 2015 Frontiers in Psychiatry (1664-0640) Frontiers Media SA
2013 - 2013 Brain Research Bulletin (0361-9230) Elsevier
2008 - 2008 European Neuropsychopharmacology (0924-977X) Elsevier

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2011 - 2020 Instructor on the postgraduate course (1 hour lecture) Fundamentals in Neuroscience (Pós-Graduação) Universidade do Minho Escola de Medicina, Portugal
2012 - 2012 Instructor of the flow cytometry practical module (4 hours) An integrative approach to cell analysis course (Pós-Graduação) Universidade do Minho Escola de Medicina, Portugal
2009 - 2009 Instructor of the practical module of flow cytometry at the postgraduate course (7 hours). Neuroimmune Interactions (Pós-Graduação) Universidade do Minho Escola de Medicina, Portugal
2005 - 2005 Instructor of the practical module of flow cytometry at the postgraduate course (5 hours) 1st Workshop on Advanced Light Microscopy and Flow Cytometry (Pós-Graduação) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2018 - 2021 ORBEA Member (Portuguese acronym for the internal Animal Welfare Body) of ICVS/3Bs Associated Laboratory
Membro
 Laboratório Associado ICVS 3B's, Portugal

Processo legal

Descrição da atividade Caso
2019/02/03 - 2019/07/04 Maternal leave (150 days according to the Portuguese Legislation).
2014/05/14 - 2014/09/11 Maternal leave (120 days according to the Portuguese Legislation)
Distinções

Prémio

2022 Best Communication award Porf. Doutor António Braga (team member)
Sociedade Portuguesa de Angiologia e Cirurgia Vascular, Portugal
2011 Honorable mention in Plenary Session Oral Presentations, VI YES Meeting
Universidade do Porto Faculdade de Medicina, Portugal
2010 Scientific Poster Honorable Mention, V YES Meeting
Universidade do Porto Faculdade de Medicina, Portugal
2010 Best Poster, XV JOCEM, National Association of Medical Students (ANEM).
2006 Honorable mention in the Ricardo Jorge Award in Public Health with the work ";The effect of IL-10 activity in Mycobacterium avium infection is dependent of the host genetic background"
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2000 Scholarship for Merit in the Degree in Biochemistry from the University of Beira Interior
Universidade da Beira Interior, Portugal

Outra distinção

2011 Travel Grant for the 2011 IBRO World Congress of Neuroscience in Florence, Italy.
International Brain Research Organization, França
2010 Fellowship for participation in IBRO/UNESCO School of Neuroscience:Neurobiology of Infectious Diseases: a view for Global Neuroscience, La Reunion, IBRO/UNESCO.
International Brain Research Organization, França
2009 Fellowship for participation in international meeting
Fundação Calouste Gulbenkian, Portugal