I am a full professor in the Computer Science and Engineering department (CSE) at Instituto Superior Técnico (IST), conducting scientific research in combinatorial algorithms, machine learning, and computational biology. Within the department, I coordinate the scientific area of programming methodology and technology. Additionally, I serve as the Chairwoman of the School Assembly at IST, an advisory body with 60 representatives. During my 33-year career at IST, I spent the first two decades as a professor in the Department of Electrical and Computer Engineering, conducting research in microelectronics and magneto-optics. During this time, I contributed to the development of the Quickchips project, enabling the establishment of Portugal's first clean room for integrated circuit manufacturing at the Institute of Systems and Computer Engineering (INESC). In 2010, I completed my habilitation exams in computational biology. This project marked the start of my research career at INESC around 36 years ago. After earning my Ph.D. in Electrical and Computer Engineering, I shifted to bioinformatics and computational biology. Over 22 years in this field, I co-founded the Knowledge Discovery and Bioinformatics (KDBIO) research group in 2002. Leading a team of 10 Ph.D. professors and around 25 master's, doctoral, and post-doc students from 2009 to 2014, we became Portugal's largest computational biology research group. In 2011, after a decade in genomics algorithm development, I ventured into technology transfer, founding HeartGenetics, Genetics and Biotechnology SA, a genetic and digital health startup. Serving as CEO for a decade, the company, co-founded in 2013, grew to 30 employees and expanded operations across the EU and Latin America. In 2020, Italian laboratory TOMALAB acquired HeartGenetics after securing over €8 million in funding, marking TOMALAB's first internationalization step. In these years, I pursued advanced training in management and entrepreneurship at the Católica Business School of Lisbon. Between 2012 and 2016, I was a member of the scientific council at IST and served on the Executive Board at the CSE Department. On the European level, I represented Portugal as a Board member (2010-2016) at the European Research Infrastructure for life data, ELIXIR, and served as Vice-chair of the Board in 2017. Currently, I am the Head of Node for ELIXIR Portugal, overseeing the country's participation in the EU’s Genomic Data Infrastructure project valued at €40 million. As a researcher at INESC-ID, I lead the Life and Health Technology thematic line, which brings together 9 research groups and over 50 researchers. In 2023, I became the coordinator for Lisbon in the new European Digital Innovation Hub ATTRACT, focusing on Artificial Intelligence and High-Performance Computing. I have authored and co-authored more than 120 papers in international journals and conferences in the areas of computational biology, bioinformatics, computer aided design and magneto-optics. I have participated in a number of programs and scientific committees of international conferences and I am a permanent reviewer of the main journals in the Computational Biology field, like Nucleic Acid Research, Bioinformatics Oxford journal, PlosOne and BMC Bioinformatics. In March 2023, I received the career award from the Order of Engineers of the Madeira region, for my contributions to the development of technologies in the field of digital health and preventive medicine. In my career I received 8 awards. In my professional activities, I have interacted with over 195 collaborators in co-authoring scientific papers. Currently, my main research focus is in the area of federated learning in healthcare and genomics medicine, where I am developing a collaboration with the Technical University of Science and Technology of Macau and with the National Cancer Center at NIH in Washington DC (where I am currently on sabbatical leave).