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In my PhD in the lab of Prof. Yves Barral, ETH, Zurich, I discovered a new checkpoint, the NoCut checkpoint. I then moved on to understand neuroepithelial development in zebrafish at the University of Cambridge, UK in the lab of Prof. William Harris. I got mechanistic insights on how nuclei move within tissues and how this ensures proper tissue development and maturation. This work was essential to secure my position as PI at the MPI-CBG in Dresden, Germany in 2010. Here I expanded my research portfolio and started cross-disciplinary collaborations. After my tenure ended in 2019, I moved to the Instituto Gulbenkian de Ciência in Oeiras, PT, where I am a group leader served as Deputy Director of Science. Since 2010, my lab has made significant headway in dissecting cell biological phenomena that shape retinogenesis. In all our studies we implemented quantitative approaches and combined experimental work with computer science and theory. We found that rim cell migration is an important driver of this tissue rearrangement during optic cup formation and elucidated of how these cells move and interact with the underlying extracellular matrix. At the neuroepithelial stage, we extracted the mechanisms that drive interkinetic nuclear migration (IKNM) and made progress in understanding the biological relevance of this widespread phenomenon. We further showed that tissue architecture can influence apical positioning of nuclei. We further dissected phenomena of retinal neuronal migration and ensuing lamination. We investigated the migration modes of diverse retinal neurons, which were understudied until then, including retinal ganglion cell migration, horizontal cell migration and emerging photoreceptor cell migration. In addition, we revealed the division patterns of retinal linages over three divisions. Overall, this led to 17 publications as a senior author in international peer-reviewed journals. I also contributed to collaborative papers and 12 review articles. I serve as ad-hoc reviewer for many international journals, including Development, Developmental Cell, Current Biology, Nature, among others, and review grants for diverse agencies among which are ERC, Wellcome Trust, National Science Foundation, HFSP and EMBO, to name a few. I taught two undergraduate modules in the Dresden Master program. In Portugal, I teach Master’s and PhD students twice a year. I was and am part of 36 Thesis advisory and 17 defence committees six of them international. I served as a member of the habilitation committee of Shahad Albadri at the Paris Sorbonne University. In the last decade, I have been invited as a speaker to 53 international conferences and workshops including prestigious hosts like EMBO, Gordon and ‘The Company of Biologists’ and many more. I could secure an HFSP Career Development Award, four grants funded by the German Research Foundation and an ERC consolidator grant in 2019. Furthermore, I was awarded the José A. Campos-Ortega Young Scientist Award of the German Society for Developmental Biology. I became a member of the EMBO Young Investigator Network in 2015 and a full EMBO member in 2020.
Ler resumo completo ↓
Identificação

Identificação pessoal

Nome completo
Caren Norden

Nomes de citação

  • Norden, Caren

Identificadores de autor

Ciência ID
A91F-57DD-5CC4
ORCID iD
0000-0001-8835-1451

Endereços de correio eletrónico

  • cnorden@igc.gulbenkian.pt (Profissional)

Moradas

  • Rua da Quinta Grande, 6, 2780-156, Oeiras, Oeiras, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia do Desenvolvimento

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Alemão (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2006 - 2010
Concluído
 Postdoctoral fellow with Prof. William A. Harris (Pós-doutoramento)
Cambridge University - Institute of Physiology, Development and Neuroscience, , Reino Unido
2002 - 2006
Concluído
 Biology (Doctor of Philosophy)
Eidgenössische Technische Hochschule Zürich, Suiça
"`Investigating spatial and temporal coordination of cytokinesis with spindle function´ - PhD Dissertation Thesis, under supervision of Prof. Yves Barral" (TESE/DISSERTAÇÃO)
1996 - 2002
Concluído
 Biochemistry (Master)
Especialização em Diplom Biochemiker
Leibniz Universität Hannover, Alemanha
""Investigating Neuronal Polarity" - Diploma Thesis at the Mount Sinai School of Medicine, New York, USA, under supervision of Prof. Bettina Winckler" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/10/01 - Atual Investigador Coordenador (carreira) (Investigação) Instituto Gulbenkian de Ciência, Portugal
2016 - 2019 Investigador Coordenador (carreira) (Investigação) Max-Planck-Institut für molekulare Zellbiologie und Genetik, Alemanha
2010 - 2015 Investigador principal (carreira) (Investigação) Max-Planck-Institut für molekulare Zellbiologie und Genetik, Alemanha
2006 - 2010 Pós-doutorado (Investigação) Cambridge University - Institute of Physiology, Development and Neuroscience, , Reino Unido

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2019 - Atual Subdirector de Unidade Orgânica Fundação Calouste Gulbenkian, Portugal
Instituto Gulbenkian de Ciência, Portugal
Projetos

Bolsa

Designação Financiadores
2019/01 - 2022/01 Shaping of the optic cup in vivo: interplay of cellular dynamics and the extracellular matrix
NA
Investigador responsável
Em curso
2017 - 2017 EMBO small grant for transcriptomics project
NA
Investigador responsável
Concluído

Projeto

Designação Financiadores
2020 - Atual Principal Researcher Biological Sciences AR, PR and CR: Cell Biology of Tissue Morphogenesis
CEECIND/03268/2018
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2019/10 - Atual makingtheretina
819046
819046
Investigador responsável
Instituto Gulbenkian de Ciência, Portugal
 European Research Council
Em curso
2018/12/01 - Atual Investigating lineage decisions of cone photoreceptors in the developing zebrafish retina
Investigador responsável
Max-Planck-Institut für molekulare Zellbiologie und Genetik, Alemanha
 Deutsche Forschungsgemeinschaft
Em curso
2017/03/01 - 2020/03 Investigating the impact of centrosome number on neuroepithelial maturation and proliferative compensation
Investigador responsável
Max-Planck-Institut für molekulare Zellbiologie und Genetik, Alemanha
 Deutsche Forschungsgemeinschaft
Concluído
2014 - 2018 EMBO Young Investigator grant: "Retinal morphogenesis" (€15.000)
Investigador responsável
Max-Planck-Institut für molekulare Zellbiologie und Genetik, Alemanha
 European Molecular Biology Organization (EMBO)
Concluído
2014/08/01 - 2017/07/01 A quantitative analysis of forces and mechanics during interkinetic nuclear migration in the developing zebrafish embryo
Investigador responsável
Max-Planck-Institut für molekulare Zellbiologie und Genetik, Alemanha
 Deutsche Forschungsgemeinschaft
Concluído
2013/07/01 - 2017/07/01 ‘Towards a morphological and evolutionary understanding of non-apical progenitors in the zebrafish retina’
Investigador
Max-Planck-Institut für molekulare Zellbiologie und Genetik, Alemanha
 Deutsche Forschungsgemeinschaft
Concluído
2012/02/01 - 2016/02/01 ‘The retina: A model to extract kinetics, mechanics and cellular interactions in neuronal migration’
Investigador responsável
Max-Planck-Institut für molekulare Zellbiologie und Genetik, Alemanha
 Human Frontier Science Program
Concluído
Produções

Publicações

Artigo em conferência
  1. "Particle-based segmentation of extended objects on curved biological membranes". Trabalho apresentado em Symposium on Biomedical Imaging (ISBI), 2021.
Artigo em revista
  1. Norden, Caren. "A Fish Eye View: Retinal Morphogenesis from Optic Cup to Neuronal Lamination". Annual Review of Cell and Developmental Biology 39 1 (2023): 175-196. http://dx.doi.org/10.1146/annurev-cellbio-012023-013036.
    10.1146/annurev-cellbio-012023-013036
  2. Mauricio Rocha-Martins; Elisa Nerli; Jenny Kretzschmar; Martin Weigert; Jaroslav Icha; Eugene W. Myers; Caren Norden. "Neuronal migration prevents spatial competition in retinal morphogenesis". Nature (2023): https://doi.org/10.1038/s41586-023-06392-y.
    10.1038/s41586-023-06392-y
  3. Elisa Nerli; Jenny Kretzschmar; Tommaso Bianucci; Mauricio Rocha-Martins; Christoph Zechner; Caren Norden. "Deterministic and probabilistic fate decisions co-exist in a single retinal lineage". The EMBO Journal (2023): https://doi.org/10.15252/embj.2022112657.
    10.15252/embj.2022112657
  4. Wu, Qian; Sacomboio, Euclides; Valente de Souza, Lara; Martins, Rui; Kitoko, Jamil; Cardoso, Sílvia; Ademolue, Temitope W.; et al. "Renal control of life-threatening malarial anemia". Cell Reports 42 2 (2023): 112057. http://dx.doi.org/10.1016/j.celrep.2023.112057.
    10.1016/j.celrep.2023.112057
  5. Soans, Karen G.; Ramos, Ana Patricia; Sidhaye, Jaydeep; Krishna, Abhijeet; Solomatina, Anastasia; Hoffmann, Karl B.; Schlüßler, Raimund; et al. "Collective cell migration during optic cup formation features changing cell-matrix interactions linked to matrix topology". Current Biology 32 22 (2022): 4817-4831.e9. http://dx.doi.org/10.1016/j.cub.2022.09.034.
    10.1016/j.cub.2022.09.034
  6. Indrischek, Henrike; Hammer, Juliane; Machate, Anja; Hecker, Nikolai; Kirilenko, Bogdan; Roscito, Juliana; Hans, Stefan; et al. "Vision-related convergent gene losses reveal SERPINE3’s unknown role in the eye". eLife 11 (2022): http://dx.doi.org/10.7554/elife.77999.
    10.7554/elife.77999
  7. Rana Amini; Archit Bhatnagar; Raimund Schlüßler; Stephanie Möllmert; Jochen Guck; Caren Norden. "Amoeboid-like migration ensures correct horizontal cell layer formation in the developing vertebrate retina". eLife 11 (2022): https://doi.org/10.7554/eLife.76408.
    10.7554/eLife.76408
  8. Vignes, Hélène; Vagena-Pantoula, Christina; Prakash, Mangal; Fukui, Hajime; Norden, Caren; Mochizuki, Naoki; Jug, Florian; Vermot, Julien. "Extracellular mechanical forces drive endocardial cell volume decrease during zebrafish cardiac valve morphogenesis". Developmental Cell (2022): http://dx.doi.org/10.1016/j.devcel.2022.02.011.
    Publicado • 10.1016/j.devcel.2022.02.011
  9. Karen G. Soans; Caren Norden; Soans, Karen G.; Norden, Caren. "Shining a light on extracellular matrix dynamics in vivo". Seminars in Cell & Developmental Biology 120 (2021): 85-93. https://doi.org/10.1016/j.semcdb.2021.05.008.
    10.1016/j.semcdb.2021.05.008
  10. Elisa Nerli; Mauricio Rocha-Martins; Caren Norden. "Asymmetric neurogenic commitment of retinal progenitors involves Notch through the endocytic pathway". eLife (2020): https://doi.org/10.7554/eLife.60462.
    Publicado • 10.7554/eLife.60462
  11. Christoph Zechner; Elisa Nerli; Caren Norden; Zechner, Christoph; Nerli, Elisa; Norden, Caren. "Stochasticity and determinism in cell fate decisions". Development 147 14 (2020): https://doi.org/10.1242/dev.181495.
    Publicado • 10.1242/dev.181495
  12. Iskra Yanakieva; Anna Erzberger; Marija Matejcic; Carl D. Modes; Caren Norden. "Tissue shape determines actin-dependent nuclear migration mechanisms in neuroepithelia". The Journal of Cell Biology 218 10 (2019): 3272-3289. https://doi.org/10.1083/jcb.201901077.
    Publicado • 10.1083/jcb.201901077
  13. Maurício Rocha-Martins; Beatriz C. de Toledo; Pedro L. Santos-França; Viviane M. Oliveira-Valença; Carlos H. Vieira-Vieira; Gabriel E. Matos-Rodrigues; Rafael Linden; et al. "De novo genesis of retinal ganglion cells by targeted expression of Klf4 in vivo". Development (2019): https://doi.org/10.1242/dev.176586.
    Publicado • 10.1242/dev.176586
  14. Norden, Caren; Lecaudey, Virginie. "Collective cell migration: general themes and new paradigms". Current Opinion in Genetics & Development 57 (2019): 54-60. http://dx.doi.org/10.1016/j.gde.2019.06.013.
    Publicado • 10.1016/j.gde.2019.06.013
  15. Adrià Voltes; Covadonga F. Hevia; Carolyn Engel-Pizcueta; Chaitanya Dingare; Simone Calzolari; Javier Terriente; Caren Norden; Virginie Lecaudey; Cristina Pujades. "YAP/TAZ-TEAD Activity Links Mechanical Cues To Specific Cell Fate Within The Hindbrain Boundaries". Development (2019): https://doi.org/10.1242/dev.176735.
    Publicado • 10.1242/dev.176735
  16. Rana Amini; Anastasia A. Labudina; Caren Norden. "Stochastic single cell migration leads to robust horizontal cell layer formation in the vertebrate retina". Development 146 (2019): https://doi.org/10.1242/dev.173450.
    Publicado • 10.1242/dev.173450
  17. Katrin Daniel; Jaroslav Icha; Cindy Horenburg; Doris Müller; Caren Norden; Jörg Mansfeld. "Conditional control of fluorescent protein degradation by an auxin-dependent nanobody". Nature Communications 9 1 (2018): https://doi.org/10.1038/s41467-018-05855-5.
    Publicado • 10.1038/s41467-018-05855-5
  18. Weigert, Martin; Schmidt, Uwe; Boothe, Tobias; Müller, Andreas; Dibrov, Alexandr; Jain, Akanksha; Wilhelm, Benjamin; et al. "Content-aware image restoration: pushing the limits of fluorescence microscopy". Nature Methods 15 12 (2018): 1090-1097. http://dx.doi.org/10.1038/s41592-018-0216-7.
    Publicado • 10.1038/s41592-018-0216-7
  19. Marija Matejcic; Guillaume Salbreux; Caren Norden. "A non-cell-autonomous actin redistribution enables isotropic retinal growth". PLOS Biology 16 8 (2018): e2006018-e2006018. https://doi.org/10.1371/journal.pbio.2006018.
    Publicado • 10.1371/journal.pbio.2006018
  20. Norden, Caren; Maurício Rocha-Martins; Rana Amini. "Neuronal Migration and Lamination in the Vertebrate Retina". Frontiers in Neuroscience (2018): https://www.frontiersin.org/articles/10.3389/fnins.2017.00742/full.
    Publicado • 10.3389/fnins.2017.00742
  21. Iskra Yanakieva; Marija Matejcic; Norden, Caren. "Choosing the right microscope to image mitosis in zebrafish embryos: A practical guide". Methods Cell Biology 145 (2018): 107-127. https://pubmed.ncbi.nlm.nih.gov/29957200/.
    Publicado • 10.1016/bs.mcb.2018.03.017
  22. Jaroslav Icha; Michael Weber; Jennifer C. Waters; Caren Norden. "Phototoxicity in live fluorescence microscopy, and how to avoid it". BioEssays 39 8 (2017): 1700003-1700003. https://doi.org/10.1002/bies.201700003.
    Publicado • 10.1002/bies.201700003
  23. Norden, Caren; Caren Norden. "Pseudostratified epithelia – cell biology, diversity and roles in organ formation at a glance". Journal of Cell Science 130 11 (2017): 1859-1863. http://dx.doi.org/10.1242/jcs.192997.
    Publicado • 10.1242/jcs.192997
  24. Jaydeep Sidhaye; Caren Norden. "Concerted action of neuroepithelial basal shrinkage and active epithelial migration ensures efficient optic cup morphogenesis". eLife 6 (2017): https://doi.org/10.7554/eLife.22689.
    Publicado • 10.7554/eLife.22689
  25. Jaroslav Icha; Christiane Kunath; Mauricio Rocha-Martins; Caren Norden. "Independent modes of ganglion cell translocation guide correct lamination in the zebrafish retina". The Journal of Cell Biology 215 2 (2016): 259-275. https://doi.org/10.1083/jcb.201604095.
    Publicado • 10.1083/jcb.201604095
  26. Icha, Jaroslav; Schmied, Christopher; Sidhaye, Jaydeep; Tomancak, Pavel; Preibisch, Stephan; Norden, Caren. "Using Light Sheet Fluorescence Microscopy to Image Zebrafish Eye Development". Journal of Visualized Experiments 110 (2016): http://dx.doi.org/10.3791/53966.
    Publicado • 10.3791/53966
  27. Taverna, E.; Mora-Bermúdez, F.; Strzyz, P.J.; Florio, M.; Icha, J.; Haffner, C.; Norden, C.; Wilsch-Braüninger, M.; Huttner, W.B.. "Non-canonical features of the Golgi apparatus in bipolar epithelial neural stem cells". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84958267539&partnerID=MN8TOARS.
    Publicado • 10.1038/srep21206
  28. Norden, Caren; Strzyz, P.J.; Marija Matejcic. "Heterogeneity, cell biology and tissue mechanics of pseudostratified epithelia: How to coordinate cell divisions and growth in tightly packed tissues". International Review Cell Molecular Biology 325 (2016): 89-118. https://pubmed.ncbi.nlm.nih.gov/27241219/.
    Publicado • 10.1016/bs.ircmb.2016.02.004
  29. Chow, R.W.; Almeida, A.D.; Randlett, O.; Norden, C.; Harris, W.A.. "Inhibitory neuron migration and IPL formation in the developing zebrafish retina". Development 142 15 (2015): 2665-2677. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938631747&partnerID=MN8TOARS.
    Publicado • 10.1242/dev.122473
  30. Strzyz, P.J.; Lee, H.O.; Sidhaye, J.; Weber, I.P.; Leung, L.C.; Norden, C.. "Interkinetic Nuclear Migration Is Centrosome Independent and Ensures Apical Cell Division to Maintain Tissue Integrity". Developmental Cell 32 2 (2015): 203-219. http://www.scopus.com/inward/record.url?eid=2-s2.0-84921614530&partnerID=MN8TOARS.
    Publicado • 10.1016/j.devcel.2014.12.001
  31. Dzafic, E.; Strzyz, P.J.; Wilsch-Bräuninger, M.; Norden, C.. "Centriole Amplification in Zebrafish Affects Proliferation and Survival but Not Differentiation of Neural Progenitor Cells". Cell Reports 13 1 (2015): 168-182. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943241820&partnerID=MN8TOARS.
    Publicado • 10.1016/j.celrep.2015.08.062
  32. Weber, I.; Ramos, A.; Strzyz, P.; Leung, L.; Young, S.; Norden, C.. "Mitotic Position and Morphology of Committed Precursor Cells in the Zebrafish Retina Adapt to Architectural Changes upon Tissue Maturation". Cell Reports 7 2 (2014): 386-397. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899633714&partnerID=MN8TOARS.
    Publicado • 10.1016/j.celrep.2014.03.014
  33. Norden, Caren; Icha, Jaroslav. "Neuronal Migration: An Overview of Modes, Molecular Mechanisms and Model Systems". eLS (2014): 1-10. https://onlinelibrary.wiley.com/doi/abs/10.1002/9780470015902.0000796.pub2.
    Publicado • https://doi.org/10.1002/9780470015902.0000796.pub2
  34. Lee, H.O.; Norden, C.. "Mechanisms controlling arrangements and movements of nuclei in pseudostratified epithelia". Trends in Cell Biology 23 3 (2013): 141-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874260628&partnerID=MN8TOARS.
    Publicado • 10.1016/j.tcb.2012.11.001
  35. Wong, G.K.W.; Baudet, M.-L.; Norden, C.; Leung, L.; Harris, W.A.. "Slit1b-Robo3 signaling and N-cadherin regulate apical process retraction in developing retinal ganglion cells". Journal of Neuroscience 32 1 (2012): 223-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855946761&partnerID=MN8TOARS.
    Publicado • 10.1523/JNEUROSCI.2596-11.2012
  36. Leung, L.; Klopper, A.V.; Grill, S.W.; Harris, W.A.; Norden, C.. "Apical migration of nuclei during G2 is a prerequisite for all nuclear motion in Zebrafish Neuroepithelia". Development 138 22 (2011): 5003-5013. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054903456&partnerID=MN8TOARS.
    Publicado • 10.1242/dev.071522
  37. Randlett, O.; Norden, C.; Harris, W.A.. "The vertebrate retina: A model for neuronal polarization in vivo". Developmental Neurobiology 71 6 (2011): 567-583. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955708659&partnerID=MN8TOARS.
    Publicado • 10.1002/dneu.20841
  38. Mendoza, M.; Norden, C.; Durrer, K.; Rauter, H.; Uhlmann, F.; Barral, Y.. "A mechanism for chromosome segregation sensing by the NoCut checkpoint". Nature Cell Biology 11 4 (2009): 477-483. http://www.scopus.com/inward/record.url?eid=2-s2.0-64049116968&partnerID=MN8TOARS.
    Publicado • 10.1038/ncb1855
  39. Norden, C.; Young, S.; Link, B.A.; Harris, W.A.. "Actomyosin Is the Main Driver of Interkinetic Nuclear Migration in the Retina". Cell 138 6 (2009): 1195-1208. http://www.scopus.com/inward/record.url?eid=2-s2.0-70149124068&partnerID=MN8TOARS.
    Publicado • 10.1016/j.cell.2009.06.032
  40. Boiko, T.; Vakulenko, M.; Ewers, H.; Yap, C.C.; Norden, C.; Winckler, B.. "Ankyrin-dependent and -independent mechanisms orchestrate axonal compartmentalization of L1 family members neurofascin and L1/neuron-glia cell adhesion molecule". Journal of Neuroscience 27 3 (2007): 590-603. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846441246&partnerID=MN8TOARS.
    Publicado • 10.1523/JNEUROSCI.4302-06.2007
  41. Norden, C.; Mendoza, M.; Dobbelaere, J.; Kotwaliwale, C.V.; Biggins, S.; Barral, Y.. "The NoCut Pathway Links Completion of Cytokinesis to Spindle Midzone Function to Prevent Chromosome Breakage". Cell 125 1 (2006): 85-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645968660&partnerID=MN8TOARS.
    Publicado • 10.1016/j.cell.2006.01.045
  42. Chang, M.C.; Wisco, D.; Ewers, H.; Norden, C.; Winckler, B.. "Inhibition of sphingolipid synthesis affects kinetics but not fidelity of L1/NgCAM transport along direct but not transcytotic axonal pathways". Molecular and Cellular Neuroscience 31 3 (2006): 525-538. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644816561&partnerID=MN8TOARS.
    Publicado • 10.1016/j.mcn.2005.11.006
  43. Mendoza, M.; Norden, C.; Barral, Y.. "Division-plane positioning: Microtubules strike back". Current Biology 15 15 (2005): http://www.scopus.com/inward/record.url?eid=2-s2.0-23244441818&partnerID=MN8TOARS.
    10.1016/j.cub.2005.07.040
  44. Norden, C.; Liakopoulos, D.; Barral, Y.. "Dissection of septin actin interactions using actin overexpression in Saccharomyces cerevisiae". Molecular Microbiology 53 2 (2004): 469-483. http://www.scopus.com/inward/record.url?eid=2-s2.0-3242877719&partnerID=MN8TOARS.
    Publicado • 10.1111/j.1365-2958.2004.04148.x
  45. Wisco, D.; Anderson, E.D.; Chang, M.C.; Norden, C.; Boiko, T.; Fölsch, H.; Winckler, B.. "Uncovering multiple axonal targeting pathways in hippocampal neurons". Journal of Cell Biology 162 7 (2003): 1317-1328. http://www.scopus.com/inward/record.url?eid=2-s2.0-0141530006&partnerID=MN8TOARS.
    Publicado • 10.1083/jcb.200307069

Outros

Outra produção
  1. Matrix topology guides collective cell migration in vivo. BioRxiv: doi: 10.1101/2022.01.31.478442. 2022. https://www.biorxiv.org/content/10.1101/2022.01.31.478442v1.
  2. Bidirectional neuronal migration coordinates retinal morphogenesis by preventing spatial competition. 2021. Norden, Caren. https://doi.org/10.1101/2021.02.08.430189.
    10.1101/2021.02.08.430189
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024 Keynote Speaker Physical Biology Circle meeting Physical Biology Circle meeting
(Oeiras, Portugal)
2023 Invited speaker at Functional Microscopy for Biology SBCF Symposium
(Giens, França)
2023 Invited speaker at the ‘Imaging Cell Dynamics’, Journal of Cell Science meeting
(Lisbon, Portugal)
2023 Invited speaker at the ‘Building Bridges in Biology’ symposium
(Oeiras, Portugal)
2022 Invited speaker at the 2nd Crick Beddington Developmental Biology symposium
(London, Reino Unido)
2022 Invited speaker at ‘Developmental Biology’ meeting
(Santa Cruz, Estados Unidos)
2022 Invited speaker and organizer ‘EMBO 3D developmental imaging’ workshop
(Oeiras, Portugal)
2022 Invited speaker at ‘Fostering Quantitative Modelling and Experimentation in Developmental Biology’ workshop
(Buxton, Reino Unido)
2022 Selected talk, Zebrafish PI meeting The European Zebrafish PI meeting
(Dresden, Alemanha)
2021/11/20 Amoeboid-like migration ensures correct horizontal cell layer formation in the developing vertebrate retina Development presents
Development, the journal (virtual)
2021/11/06 Making the retina: a tale of cell tissue interactions SPAOM (Spanish Portuguese imaging meeting)
SPAOM (virtual)
2021/10/14 The role of matrix topology for collective cell migration in vivo ‘EMBO members meeting’
EMBO (Heidelberg, Alemanha)
2021/06/19 Making the retina: from cells to tissue and back again Microscience Microscopy Congress 2021 (mmc2021)’
MMC (virtual)
2021/05/03 Optic cup formation: The role of cell-matrix interactions EMBO cell polarity and membrane dynamics
EMBO (virtual)
2021/02/15 Matrix topology guides collective cell migration in vivo: Example of the optic cup ‘Mechanics of epithelia symposium’ series, Cambridge University, UK
Cambridge University, UK
2021 Invited speaker at the Thirsting for Theoretical Biology series (virtual) Thirsting for Theoretical Biology
Tata Institute of Fundamental Research
2021 Invited Speaker at the Cambridge Morphogenesis Series (virtual) Cambridge Morphogenesis Series
2021 Invited Speaker at the ‘Cambridge Morphogenesis Series’, Cambridge University Cambridge Morphogenesis Series
((virtual))
2021 Invited speaker at the ‘Thirsting for Theoretical Biology’ series Thirsting for Theoretical Biology
Tata Institute of Fundamental Research ((virtual))
2021 Invited speaker at the ‘Mechanics of epithelia symposium’ series ¿Mechanics of epithelia symposium¿ series, Cambridge University, UK
((virtual))
2021 Invited speaker at the ‘EMBO cell polarity and membrane dynamics’ conference EMBO cell polarity and membrane dynamics
((virtual))
2021 Invited plenary speaker at the ‘Microscience Microscopy Congress 2021 (mmc2021)’ conference Microscience Microscopy Congress 2021 (mmc2021)¿
((virtual))
2021 Invited speaker at ‘EMBO members meeting’ ¿EMBO members meeting¿
(Heidelberg, Alemanha)
2021 Invited speaker at SPAOM (Spanish Portuguese imaging meeting) SPAOM (Spanish Portuguese imaging meeting)
((virtual))
2021 Invited speaker at ‘Development presents’ online event celebrating 25 years of zebrafish research Development presents
((virtual))
2020 Invited keynote speaker at Australian New Zealand Zebrafish meeting: Generating the vertebrate retina Australian New Zealand Zebrafish meeting
Australien zebrafish society (Yara Valley, Austrália)
2019 Invited speaker at Catalyzing Progress Symposium: Marking the retina - The interplay of single cell biology and tissue-wide phenomena Catalyzing Progress Symposium
Max F. Perutz Laboratories (Vienna, Áustria)
2019 Invited Speaker LS2 Life Science Switzerland Meeting: Marking the retina - The interplay of single cell biology and tissue-wide phenomena LS2 Life Science Switzerland Meeting
Life Science Switzerland (Zurich, Suiça)
2019 Invited speaker at EMBO workshop Mechanical forces in development: How tissue shape influences nuclear movement in neuroepithelia EMBO workshop Mechanical forces in development Heidelberg, Germany
EMBO (Heidelberg, Alemanha)
2019 Invited Speaker Morphogenesis in Animals and Plants, Search for Principles workshop: Eye development in vertebrates Morphogenesis in Animals and Plants: Search for Principles workshop Santa Barbara, USA
Kavli Institute (Santa Barbara, Estados Unidos)
2019 Selected Speaker: Tissue environment in health and disease conference: Marking the retina - The interplay of single cell biology and tissue-wide phenomena Tissue environment in health and disease, Lisbon, Portugal.
Champalimaud (Lisbon, Portugal)
2019 Invited speaker at Symposium - Dynamics of morphogenesis in cells, tissues and organisms ASCB/EMBO meeting
(Estados Unidos)
2019 Invited speaker at Physics of Life EMBO workshop Physics of Life EMBO workshop
(Território Palestiniano)
2019 Invited Speaker at session led by European Research Council: The dos and donts when applying for ERC grants EMBO workshop Mechanical forces in development
2018 Invited Speaker at 5th European Zebrafish Principal Investigators Meeting: Organoids as model tissue - opportunity, threat, hoax or all of the above for zebrafish research? The European Zebrafish PI meeting
(Trento, Itália)
2018 Invited speaker at 10th Light Sheet Fluorescence Microscopy Conference: Photoreceptors catching the light(sheet) - Fate, movements and lamination 10th Light Sheet Fluorescence Microscopy Conference
(Dresden, Alemanha)
2018 Invited speaker at FSER meeting Cell Polarity and Morphogenesis: Vertebrate eye development from epithelium to lamination FSER meeting Cell Polarity and Morphogenesis
(Les Treille, França)
2018 Invited speaker at the German Cell Biology Society Meeting: Retinal formation - From cells to tissue German Cell Biology Society Meeting
(Leipzig, Alemanha)
2018 Invited speaker at Visual System Development Gordon Research conference: Lamination in the Vertebrate Retina Visual System Development Gordon Research conference
(Barga, Itália)
2018 Invited speaker at the 2nd Sino-German Symposium on Development and Maintenance of Brain Function - From Basic Mechanisms to Disease: The cell biology of retinal Lamination 2nd Sino-German Symposium: Development and Maintenance of Brain Function: From Basic Mechanisms to Disease
(Berlin, Alemanha)
2017 Invited plenary speaker at Till and McCulloch Stem Cell network meeting: Actin dependent mechanisms for apical interkinetic nuclear migration vary depending on tissue architecture Till and McCulloch Stem Cell network meeting
(Mont Tremblant, Canadá)
2017 Invited speaker at Engineering life conference: Actin dependent mechanisms for apical interkinetic nuclear migration vary depending on tissue architecture Engineering life conference
(Dresden, Alemanha)
2017 Invited speaker at the 10th European Zebrafish meeting: How tissue shape influences nuclear migration in different zebrafish neuroepithelia 10th European Zebrafish meeting
(Budapest, Hungria)
2017 Invited speaker at EMBO Conference Cell biology of the neuron: Neuronal lamination in the vertebrate retina - From cells to tissue EMBO Conference Cell biology of the neuron
(Heraklion, Grécia)
2017 Invited EMBO YIP lecture at ETH Biochemistry Department Symposium: The making of the zebrafish retina: from simple epithelium to laminated tissue EMBO YIP lecture at ETH Biochemistry Department Symposium
(Zurich, Suiça)
2017 Invited speaker at Physics of Biology conference: Mechanics of retinal development Physics of Biology conference
(Geneva, Suiça)
2017 Invited Speaker at ‘Retina Informationstag’, public event for patients and their relatives about basic science of retinal development at CRTD Dresden
2016 Invited speaker at the Physics of Biology conference: Retinal shape maintenance during development Physics of Biology conference
(Geneva, Suiça)
2016 Invited speaker at EMBO Young Scientist Forum: Cell biology and morphogenesis of the vertebrate eye - from epithelia to neuronal lamination EMBO Young Scientist Forum
(Lisbon, Portugal)
2016 Invited speaker at SBBC 2016 - XVIII Congress of the Brazilian Society for Cell Biology: The making of the vertebrate retina from cell to tissue SBBC 2016 - XVIII Congress of the Brazilian Society for Cell Biology
(Sao Paulo, Brasil)
2016 Invited speaker at 18th Winter Neuroscience Conference: Retinal Ganglion Cell migratio - the first step in vertebrate retinal lamination 18th Winter Neuroscience Conference
(Soelden, Áustria)
2015 Quantitative analysis of retinal neuroepithelial growth EMBO YIP lecture: 17th EMBL PhD symposium
(Heidelberg, Alemanha)
2015 Interkinetic nuclear migration is centrosome independent and ensures apical cell division to maintain tissue integrity 9th Cilia, flagella and centrosomes congress, 8th interregional Fish Meeting, Award ceremony at joint meeting German and French Societies for Developmental Biology
-- (--)
2015 Cell Biology and Mechanics that drive Proliferation in the Retinal Neuroepithelium Women in Science Series
University of Münster
2015 Interkinetic nuclear migration is centrosome independent but important for successful tissue maturation 9th Cilia, flagella and centrosomes congress
(Strasbourg, França)
2015 The development of the zebrafish retina from cells to tissue 8th interregional Fish Meeting
(Klingenmünster, Alemanha)
2015 How to build a retina: From cells to tissue, from epithelium to laminated structure Award ceremony at joint meeting German and French Societies for Developmental Biology
(Nürnberg, Alemanha)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023 - Atual Investigating the cell biology and translocation patterns of bipolar cells' lamination in the developing vertebrate retina
Orientador
Universidade Nova de Lisboa, Portugal

Instituto Gulbenkian de Ciência, Portugal
2023 - Atual Cellular mechanisms of compensatory proliferation in the developing vertebrate retina
Orientador
Instituto Gulbenkian de Ciência, Portugal

Universidade Nova de Lisboa, Portugal
2020/03 - 2024/02 Investigating the influence of nuclear and tissue properties in pseudostratified neuroepithelia maturation
Orientador
Universidade Nova de Lisboa, Portugal

Instituto Gulbenkian de Ciência, Portugal
2020/03 - 2024 Investigating the influence of pseudostratification for neuroepithelial development
Orientador
Universidade Nova de Lisboa, Portugal

Instituto Gulbenkian de Ciência, Portugal
2018 - 2022 Investigating progenitor cell lineages and their regulation during zebrafish retinal neurogenesis
Orientador
Technische Universität Dresden, Alemanha
2017 - 2022 The role of extracellular matrix topology on collective cell migration during zebrafish optic cup formation
Orientador
Technische Universität Dresden, Alemanha
2020/09 - 2021/03 Investigating the robustness and plasticity of photoreceptor lineages during retinal development
Orientador
 Regenerative Biology and Medicine (Mestrado)
Technische Universität Dresden, Alemanha

Instituto Gulbenkian de Ciência, Portugal
2020/02 - 2020/10 Temporal characterization of invagination during optic cup formation
Orientador
École Normale Supérieure, França

Instituto Gulbenkian de Ciência, Portugal
2014 - 2019 Tissue shape determines actin-dependent nuclear migration mechanisms in neuroepithelia
Orientador
Technische Universität Dresden, Alemanha
2018/01/04 - 2018/09/01 Investigating horizontal cell migration in the developing zebrafish retina
Orientador
Technische Universität Dresden, Alemanha
2013/11/01 - 2018/04/15 Coordination of tissue shape and size in the developing zebrafish neuroepithelium
Orientador
Technische Universität Dresden, Alemanha
2013/09/01 - 2017/11/15 Cellular dynamics in zebrafish optic cup morphogenesis
Orientador
Technische Universität Dresden, Alemanha
2012/10/01 - 2017/01/15 Ganglion cell translocation across the retina and its importance for retinal lamination
Orientador
Technische Universität Dresden, Alemanha
2015/03/01 - 2015/09/01 Investigation of centrosome amplification in the developing zebrafish
Orientador
Technische Universität Dresden, Alemanha
2010/11/01 - 2015/01/15 The significance of bringing nuclei to the apical surface for division in the pseudostratified epithelium of the developing zebrafish retina
Orientador
Technische Universität Dresden, Alemanha
2010/01/10 - 2014/10/01 Committed precursor cells in zebrafish retinal development
Orientador
Technische Universität Dresden, Alemanha
2014/03/01 - 2014/09 Kinetics and Dynamics of Committed Precursors in the Developing Zebrafish Retina
Orientador
Technische Universität Dresden, Alemanha
2011/11/01 - 2012/11 Uderstanding emergence and cell cycle dynamics of non-apical progenitors in the zebrafish retina
Orientador
 developmental biology (Mestrado)
Universidade de Lisboa, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2022 - Atual Organizer of the practical course EMBO 3D developmental imaging Main organizer: Gaby Martins (2022)
Oficina (workshop) (Coorganizador)
2019 - Atual Organizer of the Symposium: Dynamics of morphogenesis in cells, tissues and organisms (ASCB/EMBO meeting) (2019)
Simpósio (Membro da Comissão Organizadora)
2015 - Atual Head of Research Group Leaders, initiating communication with directors, students and postdocs (2015 - 2015)
Outro (Presidente da Comissão Organizadora)
 Max-Planck-Institut für molekulare Zellbiologie und Genetik, Alemanha
2019 - 2019 Organizer of the EMBO YIP sectorial Meeting on Tissue Morphogenesis Co-organizer Kim Bak Jensen (2019 - 2019)
Oficina (workshop) (Coorganizador)
 European Molecular Biology Organization (EMBO), Alemanha
2018/03/20 - 2018/03/23 Workshop Organizer at the 5th European Zebrafish Principal Investigators Meeting: Morphogenesis Workshop (2018/03/21 - 2018/03/21)
Oficina (workshop) (Coorganizador)
 CIBIO-Centre for Integrative Biology University of Trento, Itália
2018 - 2018 Organiser of the EMBO YIP sectorial meeting on tissue morphogenesis Co-organizer: Frank Schnorrer (2018)
Encontro (Coorganizador)
2017 - 2017 Organiser at EMBO YIP sectorial meeting on tissue morphogenesis Co-organizer Yohanns Bellaiche (2017)
Encontro (Coorganizador)
2017 - 2017 Workshop Organizer: Imaging and Cell Tracking (2017 - 2017)
Oficina (workshop) (Membro da Comissão Organizadora)
 Medizinische Fakultät Carl Gustav Carus an der Technischen Universität Dresden, Alemanha
2016 - 2016 Organiser of EMBO YIP sectorial meeting on tissue morphogenesis Co-organizer Julien Vermot (2016 - 2016)
Encontro (Coorganizador)
2012 - 2014 Thursday seminar committee (International seminar series at MPI-CBG) (2012 - 2014)
Seminário (Presidente da Comissão Organizadora)
 Max-Planck-Institut für molekulare Zellbiologie und Genetik, Alemanha
2013 - 2013 MPI-CBG Research Group Leader retreat, Bad Schandau, Germany (2013 - 2013)
Encontro (Membro da Comissão Organizadora)
 Max-Planck-Institut für molekulare Zellbiologie und Genetik, Alemanha

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2019 - Atual Co-Chair at Symposium Dynamics of morphogenesis in cells, tissues and organisms
Simpósio
 Symposium Dynamics of morphogenesis in cells, tissues and organisms
2018 - Atual Workshop Chair at the 5th European Zebrafish Principal Investigators Meeting: Morphogenesis Workshop
Encontro
 5th European Zebrafish Principal Investigator meeting
2017 - Atual Invited Speaker forcSFB 655 Closing Symposium: Cells into Tissue
Encontro
 Cells into Tissue
Medizinische Fakultät Carl Gustav Carus an der Technischen Universität Dresden, Alemanha
2015 - Atual Speaker at ‘Science day’ in local secondary school (age 14-18) in Dresden
Festival
2011 - Atual Speaker at ‘Retina Informationstag’, public event for patients and their relatives about basic science of retinal development at CRTD Dresden
Exposição
2017 - 2017 Invited chair at the 10th European Zebrafish meeting
Encontro
 10th European Zebrafish meeting

Arbitragem científica em conferência

Nome da conferência Local da conferência
2016 - Atual EMBO YIP sectorial meeting on tissue morphogenesis Max-Planck-Institut für molekulareZellbiologie und Genetik, Dresden, Germany

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2010 - Atual Cell Reports, Development, Developmental Biology, Developmental Cell, Developmental Dynamics, eLife, EMBO Journal, Journal of Cell Biology, Molecular Biology of the Cell, Nature Communications, Open Biology, PLoS Biology, PLoS Genetics, Review Commons.
2015 - 2020 Scientific Reports Nature Publishing Group

Comissão de avaliação

Descrição da atividade
Tipo de assessoria 		Instituição / Organização Entidade financiadora
2010 - Atual PhD Thesis Reviewer and Jury member, since 2010, of 6 international students (iMM/Lisbon; Geneva University/Switzerland; Cambridge University/UK; UC/LMCB London/UK; INSERM SCBR Institute/France; UC/OD London/UK )
Avaliador
2010 - Atual Panel Member for Funding Agencies: Agence Nationale de la Recherche (ANF), LS3: Cell biology, developmental biology and evolution (France)
Avaliador
2010 - Atual Reviewer for Funding Agencies : Agence Nationale de la Recherche (ANF) (France), BBSRC (UK), Deutsche Forschungsgemeinschaft (DFG) (Germany), EMBO short-term and long-term fellowships (Europe), Horizon 2020 program (European Commission), MRC (UK), National Science Foundation (NSF) (USA), Vienna Science and Technology Fund (Austria), Wellcome Trust (UK).
Avaliador
2021/01/11 - 2021/06/20 Panel member: Agence Nationale de la Recherche (ANR), LS3: Cell biology, developmental biology and evolution (France).
Avaliador
 Agence nationale de la recherche, França Agence nationale de la recherche
2014 - 2019 Committee member of 11 PhD researchers, of DIGS-BB program
Membro
2010/11 - 2019 Advisory Committee member of 31 PhD theses, in the context of the DIGS-BB IMPRS PhD program
Membro
 Technical University Dresden, Alemanha
2010 - 2015 Otto Hahn medal for outstanding Max Planck PhD students
Membro
 Max-Planck-Institut für molekulare Zellbiologie und Genetik, Alemanha

Consultoria / Parecer

Descrição da atividade Instituição / Organização
2012 - Atual Guardian Angel (Ombudsperson) for PhD students of the DIGS-BB program, elected by students Max-Planck-Institut für molekulare Zellbiologie und Genetik, Alemanha

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2023 - Atual 14th course of Developmental Biology Institut Curie, França
2015/09/01 - Atual Module Organizer in Master Program Lecture series ‘Cell Biology’. Development and Regeneration (Mestrado) Technical University Dresden, Alemanha
2021 - 2023 Lecture in FCUL Masters course ‘Development and Evolution’ (Mestrado integrado) Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2019 - 2022 IBB PhD course organization of ‘Cell Biology of Development’ segment and lecture Cell Biology of Development (Doutoramento)
2013/09/01 - 2019/01/31 ‘Stem Cells, Development and Regeneration’: ‘Cytoskeleton’ and ‘Ectoderm’. Development and Regeneration (Mestrado) Technical University Dresden, Alemanha
2018 - 2018 9th course of Developmental Biology, Curie Institute, Paris, France
2010 - 2018 DIGS-BB Predoc course (Curso de doutoramento (conclusão de unidades curriculares))
2017 - 2017 8th course of Developmental Biology, Curie Institute, Paris, France
2015 - 2016 Dresden Summer School of Systems Biology, Dresden, Germany
2014 - 2016 EMBO Light Sheet Microscopy practical course, Dresden, Germany
2014 - 2014 EMBO practical course: 3D Developmental Imaging, Oeiras, Portugal
2011 - 2011 EMBO practical course: Imaging Infection, Pretoria, South Africa

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2023 - Atual Habilitation committee member HDR of Shahad Albadri
Membro
 Sorbonne Université, França
2017 - 2019 ‘Preparing for the academic job-market’ - Training for postdocs: from application to chalk talk.
Membro
 Max-Planck-Institut für molekulare Zellbiologie und Genetik, Alemanha
2012 - 2019 Guardian Angel (Ombudsperson
Coordenador
2010 - 2019 Committee member of 4 Master Thesis within different master programs.
Membro
2017 - 2017 Member of Organizing Committee of Workshop: Imaging and Cell Tracking
Membro
 Medizinische Fakultät Carl Gustav Carus an der Technischen Universität Dresden, Alemanha
2015 - 2015 Head of Research Group Leaders, initiating communication with directors, students and postdocs
Coordenador
2011 - 2014 Purchase Board
Membro
 Max-Planck-Institut für molekulare Zellbiologie und Genetik, Alemanha
2011 - 2014 Head of Thursday seminar committee (International seminar series at MPI-CBG)
Coordenador

Outro júri / avaliação

Descrição da atividade Instituição / Organização
2022 - Atual Guest Editor at eLife eLife Sciences Publications Ltd, Reino Unido
2015 - Atual Editorial Board Member for Scientific Reports (Nature Publishing Group) Nature Publishing Group, Reino Unido
2010 - Atual AD-HOC REVIEWER at the following international peer-reviewed Journals (16): BioEssays, Development, Developmental Biology, Developmental Cell, Developmental Dynamics, eLife, EMBO Journal, Frontiers in Cellular Neuroscience, Journal of Cell Biology, Journal of Visual Experiments, Molecular Biology of the Cell, Nature Chemistry, Nature Communications, Open Biology, PLoS Biology, PLoS Genetics
2010 - Atual AD-HOC REVIEWER for the following grant agencies (6): Agence Nationale de la Recherche (ANF) (France), Deutsche Forschungsgemeinschaft (DFG) (Germany), EMBO short-term and long-term fellowships (Europe), National Science Foundation (NSF) (USA), Vienna Science and Technology Fund (Austria), Horizon 2020 program (European Commission)

Tutoria

Tópico Nome do aluno
2021 - Atual Mentoring of young PIs Nicoletta Petridou
Distinções

Prémio

2015 EMBO Young Investigator Program (YIP)
European Molecular Biology Organization (EMBO), Alemanha
2015 José A. Campos-Ortega Young Scientist Award
German Society for Developmental Biology, Alemanha
2012 HFSP Career Development Award
Human Frontier Science Program, França
2007 HFSP Long Term Fellowship
Human Frontier Science Program, França
2007 EMBO Long Term Fellowship Award
European Molecular Biology Organization (EMBO), Alemanha

Título

2020 EMBO member
European Molecular Biology Organization (EMBO), Alemanha