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Dr. Carsten Ehrhardt is Professor in Pharmaceutics and Biopharmaceutics at the School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin. He was elected Fellow of Trinity College Dublin in 2013. Carsten has obtained his Ph.D. degree in Biopharmaceutics from Saarland University in 2003. His research is focused on lung drug disposition, pulmonary epithelial transport and molecular origins of airways disease. He has edited 1 book and (co-)authored 113 peer-reviewed publications, 12 book chapters and more than 250 abstracts and conference proceedings. Carsten has given over 150 invited oral presentations at research institutions, international conferences and workshops. He is a member of Gesellschaft für Wehrmedizin und Wehrpharmazie (VdSO), Deutsche Pharmazeutische Gesellschaft (DPhG), American Association of Pharmaceutical Scientists (AAPS), International Society for Aerosols in Medicine (ISAM), American Physiological Society (APS) and Japanese Society for the Study of Xenobiotics (JSSX). Carsten is the proud recipient of honours and awards from DPhG, APS and Galenus Foundation. He is Section Editor of European Journal of Pharmaceutical Sciences and Associate Editor of Journal of Aerosol Medicine and Pulmonary Drug Delivery. He actively serves on the Editorial Boards of European Journal of Pharmaceutics and Biopharmaceutics, Pharmaceutical Research, and Pharmaceutics.
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Identificação

Identificação pessoal

Nome completo
Carsten Ehrhardt

Nomes de citação

  • Ehrhardt, Carsten

Identificadores de autor

Ciência ID
AB10-196F-2313
ORCID iD
0000-0003-0730-1829
Formação
Grau Classificação
2000/01/04 - 2003/03/26
Concluído
 Department of Biopharmaceutics and Pharmaceutical Technology, Doctor rerum naturalium (Doctor)
Universität des Saarlandes, Alemanha
 summa cum laude
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2008/10 - 2012/07 Gestão de Ciência e Tecnologia Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
2003/09 - 2006/09 Investigador Coordenador (carreira) (Investigação) Universität des Saarlandes, Alemanha
Universität des Saarlandes, Alemanha
2003/03 - 2003/09 Pós-doutorado (Investigação) Universität des Saarlandes, Alemanha
Universität des Saarlandes, Alemanha
2000/01 - 2003/03 Assistente de Investigação (carreira) (Investigação) Universität des Saarlandes, Alemanha
Universität des Saarlandes, Alemanha

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2017/10 - Atual Professor Catedrático (Docente Universitário) Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
2017/07 - 2022/06 Professor Associado Convidado (Docente Universitário) University of Southern California Department of Pharmacology and Pharmaceutical Sciences, Estados Unidos
University of Southern California Department of Pharmacology and Pharmaceutical Sciences, Estados Unidos
2011/08 - 2017/09 Professor Associado (Docente Universitário) Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
2008/02 - 2017/01 Professor Associado Convidado (Docente Universitário) University of Southern California Department of Pharmacology and Pharmaceutical Sciences, Estados Unidos
University of Southern California Department of Pharmacology and Pharmaceutical Sciences, Estados Unidos
2010/03 - 2014/07 Professor Catedrático Convidado (Docente Universitário) Université Claude Bernard Lyon 1 Institut des Sciences Pharmaceutiques et Biologiques Faculté de Pharmacie de Lyon, França
Université Claude Bernard Lyon 1 Institut des Sciences Pharmaceutiques et Biologiques Faculté de Pharmacie de Lyon, França
2008/10 - 2011/08 Leitor (Docente Universitário) Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
2004/08 - 2008/09 Leitor (Docente Universitário) Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
Projetos

Bolsa

Designação Financiadores
2022/09 - Atual Development of ergothioneine-containing liposomes for aerosol therapy of chronic obstructive pulmonary disease
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Investigador responsável
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences
Em curso
2023/08 - 2026/08 Studying the influence of organic cation transporters on the pulmonary disposition of inhaled drugs with PET imaging in rats
P36738
Co-Investigador Responsável (Co-IR)
Fonds zur Förderung der wissenschaftlichen Forschung
2022/09 - 2026/08 STOP SPREAD BAD BUGS
101073263
Co-Investigador Responsável (Co-IR)
European Commission Marie Sklodowska-Curie Actions
2021/09 - 2025/08 Mechanistic and targeting studies on orellanine as a potential treatment of clear cell renal cell carcinoma
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Co-Investigador Responsável (Co-IR)
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences
2021/01 - 2022/12 Evaluation of the impact of membrane efflux transporters in the selective lung distribution of inhaled drugs
IP/2020/0959
Investigador responsável
Enterprise Ireland
2019/02 - 2022/03 Establishment and validation of an isolated and perfused porcine lung model for inhalation biopharmaceutical investigations
IP/2019/0797
Investigador responsável
Enterprise Ireland
2020/02 - 2021/08 Effect of tobacco smoke on the locations of vitamin C carrier proteins in chronic obstructive lung disease
TSA-2020-34968, TRY 39,400
Co-Investigador Responsável (Co-IR)
Istanbul Teknik Üniversitesi Bilimsel Arastirma Projeleri Koordinasyon Birimi
2018/09 - 2021/08 PET/MR imaging to assess the role of membrane transporters in pulmonary disposition of inhaled drugs
LSC17-009
Co-Investigador Responsável (Co-IR)
2018/01 - 2020/12 Development of a Biopharmaceutics Classification System for Inhalation Based Drug Products (iBCS)
-
Co-Investigador Responsável (Co-IR)
Product Quality Research Institute
2015/09 - 2018/08 Mesenchymal stem cells in emphysema: finding the right niche for alveolar repair
-
Co-Investigador Responsável (Co-IR)
Longfonds
2015/09 - 2018/08 Development of broad-spectrum anti-viral agents
DKK6,500,000
Co-Investigador Responsável (Co-IR)
Danmarks Frie Forskningsfond
2014/09 - 2018/08 Drug transporter effects in smoke-related lung diseases
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Investigador responsável
Republic of Iraq Ministry of Higher Education and Scientific Research
2014/07 - 2018/06 Role of OCTN1 in tobacco-related COPD
-
Investigador responsável
Flight Attendant Medical Research Institute
2015/04 - 2016/09 Role of vitamin C transporters in tobacco-related chronic obstructive pulmonary disease
3001 Project Grant 115S156, TRY 86,855
Co-Investigador Responsável (Co-IR)
Türkiye Bilimsel ve Teknolojik Arastirma Kurumu
2014/07 - 2015/06 Formulation and characterisation of Trojan systems for inhalation therapy based on budesonide containing nanoparticles
-
Investigador responsável
Ministério da Educação
2012/07 - 2015/06 Modeling of COPD by novel RAGE transgenic mice
-
Co-Investigador Responsável (Co-IR)
Flight Attendant Medical Research Institute
2013/12 - 2014/11 Establishment of NCI-H441 cells as an in vitro model for pulmonary drug disposition studies
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Investigador responsável
Chiesi Farmaceutici SpA
2011/12 - 2014/04 Characterisation of absorption pathways of CPZEN-45 across respiratory epithelial barrier
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Investigador responsável
Access to Advanced Health Institute
2007/12 - 2012/12 Oesophageal cancer - towards new therapies
TRA/2007/11
Co-Investigador Responsável (Co-IR)
Health Research Board
2009/10 - 2012/09 Functional expression of the key ion channels within different alveolar epithelial cell types
-
Investigador responsável
Irish Research Council
2007/10 - 2010/09 Role of PKC in inflammatory processes in the lung and bowel diseases
-
Investigador responsável
Irish Research Council
2006/05 - 2010/04 Nanopharmacology in platelet research: focus on nitric oxide and matrix metalloproteinases
-
Co-Investigador Responsável (Co-IR)
Science Foundation Ireland
2007/10 - 2008/10 Liposomal drug carrier systems for inhalation chemotherapy of lung cancer
PC/2007/081
Investigador responsável
Enterprise Ireland
2004/10 - 2008/09 Galenos Euro-PhD: Towards a European PhD in Advanced Drug Delivery
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Investigador responsável
2007/06 - 2007/09 Development of a spray-dried instant liposome formulation
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Investigador responsável
2006/10 - 2007/09 Establishment of a primary culture of human alveolar epithelial cells
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Investigador responsável
The University of Dublin Trinity College
2007/07 - 2007/07 Development and characterisation of biopharmaceutical models for practised and novel drug delivery routes
-
Investigador responsável
Pfizer Inc
2006/01 - 2006/07 Studies on absorption of salbutamol across the respiratory epithelium
-
Investigador responsável
Sumitomo Pharma America Inc
2002/08 - 2005/07 Development characterisation of an in vitro model based on human cornea and conjunctiva epithelial cells
-
Co-Investigador Responsável (Co-IR)
Ursapharm Arzneimittel GmbH
2004/02 - 2004/09 Absorption mechanisms and pathways for serum proteins and peptide drugs via pulmonary alveolar epithelium cells
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Investigador responsável
Novo Nordisk A/S Global Research
2002/06 - 2004/05 Assessment of telomerase inhibitors for the inhalation treatment of lung cancer
-
Co-Investigador Responsável (Co-IR)
Deutsche Hautkrebs-Stiftung
2000/01 - 2002/08 Establishment and characterisation of in vitro models for the assessment of pulmonary drug absorption
-
Co-Investigador Responsável (Co-IR)
Bundesinstitut für Risikobewertung
Produções

Publicações

Artigo em revista
  1. Falade, Balikis; Ehrhardt, Carsten. "In vitro dissolution testing methods for inhaled drugs". Istanbul Journal of Pharmacy 53 2 (2023): 239-250. http://dx.doi.org/10.26650/istanbuljpharm.2023.1005069.
    10.26650/istanbuljpharm.2023.1005069
  2. Mairinger, Severin; Hernández-Lozano, Irene; Zachhuber, Lena; Filip, Thomas; Löbsch, Mathilde; Zeitlinger, Markus; Hacker, Marcus; Ehrhardt, Carsten; Langer, Oliver. "Effect of budesonide on pulmonary activity of multidrug resistance-associated protein 1 assessed with PET imaging in rats". European Journal of Pharmaceutical Sciences 184 (2023): 106414. http://dx.doi.org/10.1016/j.ejps.2023.106414.
    10.1016/j.ejps.2023.106414
  3. Mairinger, Severin; Hernández-Lozano, Irene; Filip, Thomas; Löbsch, Mathilde; Stanek, Johann; Zeitlinger, Markus; Hacker, Marcus; et al. "Influence of P-glycoprotein on pulmonary disposition of the model substrate [11C]metoclopramide assessed by PET imaging in rats". European Journal of Pharmaceutical Sciences 183 (2023): 106404. http://dx.doi.org/10.1016/j.ejps.2023.106404.
    10.1016/j.ejps.2023.106404
  4. Johannes A. Sake; Mohammed Ali Selo; Lyubomyr Burtnyak; Henriette E. Dähnhardt; Camelia Helbet; Severin Mairinger; Oliver Langer; Vincent P. Kelly; Carsten Ehrhardt. "Knockout of ABCC1 in NCI-H441 cells reveals CF to be a suboptimal substrate to study MRP1 activity in organotypic in vitro models". European Journal of Pharmaceutical Sciences (2023): https://doi.org/10.1016/j.ejps.2022.106364.
    10.1016/j.ejps.2022.106364
  5. Tundisi, Louise Lacalendola; Ataide, Janaína Artem; Costa, Juliana Souza Ribeiro; Coêlho, Diego de Freitas; Liszbinski, Raquel Bester; Lopes, André Moreni; Oliveira-Nascimento, Laura; et al. "Nanotechnology as a tool to overcome macromolecules delivery issues". Colloids and Surfaces B: Biointerfaces 222 (2023): 113043. http://dx.doi.org/10.1016/j.colsurfb.2022.113043.
    10.1016/j.colsurfb.2022.113043
  6. Severin Mairinger; Irene Hernández-Lozano; Markus Zeitlinger; Carsten Ehrhardt; Oliver Langer. "Nuclear medicine imaging methods as novel tools in the assessment of pulmonary drug disposition". Expert Opinion on Drug Delivery (2022): https://doi.org/10.1080/17425247.2022.2137143.
    10.1080/17425247.2022.2137143
  7. Julia Cedran Coco; Janaína Artem Ataide; Johannes A. Sake; Elias Basile Tambourgi; Carsten Ehrhardt; Priscila Gava Mazzola. "In vitro antioxidant and wound healing properties of baru nut extract (Dipteryx alata Vog.) in pulmonary epithelial cells for therapeutic application in chronic pulmonary obstructive disease (COPD)". Natural Product Research (2022): https://doi.org/10.1080/14786419.2021.1984909.
    10.1080/14786419.2021.1984909
  8. Mairinger, Severin; Hernández-Lozano, Irene; Filip, Thomas; Sauberer, Michael; Löbsch, Mathilde; Stanek, Johann; Wanek, Thomas; et al. "Impact of P-gp and BCRP on pulmonary drug disposition assessed by PET imaging in rats". Journal of Controlled Release 349 (2022): 109-117. http://dx.doi.org/10.1016/j.jconrel.2022.06.065.
    10.1016/j.jconrel.2022.06.065
  9. Menzel, Viktoria; Ziegler, Matthias; Hante, Nadhim; Sake, Johannes A.; Santos-Martinez, Maria Jose; Ehrhardt, Carsten; Kasper, Michael; Barth, Kathrin. "Fyn-kinase and caveolin-1 in the alveolar epithelial junctional adherence complex contribute to the early stages of pulmonary fibrosis". European Journal of Pharmaceutical Sciences 175 (2022): 106236. http://dx.doi.org/10.1016/j.ejps.2022.106236.
    10.1016/j.ejps.2022.106236
  10. Hernández-Lozano, Irene; Mairinger, Severin; Filip, Thomas; Sauberer, Michael; Wanek, Thomas; Stanek, Johann; Sake, Johannes A.; et al. "PET imaging to assess the impact of P-glycoprotein on pulmonary drug delivery in rats". Journal of Controlled Release 342 (2022): 44-52. http://dx.doi.org/10.1016/j.jconrel.2021.12.031.
    10.1016/j.jconrel.2021.12.031
  11. Selo, Mohammed Ali; Sake, Johannes A.; Kim, Kwang-Jin; Ehrhardt, Carsten. "In vitro and ex vivo models in inhalation biopharmaceutical research — advances, challenges and future perspectives". Advanced Drug Delivery Reviews 177 (2021): 113862. http://dx.doi.org/10.1016/j.addr.2021.113862.
    10.1016/j.addr.2021.113862
  12. Selo, Mohammed Ali; Sake, Johannes A.; Ehrhardt, Carsten; Salomon, Johanna J.; Mohammed Ali Selo; Johannes A. Sake; Carsten Ehrhardt; Johanna J. Salomon. "Organic Cation Transporters in the Lung—Current and Emerging (Patho)Physiological and Pharmacological Concepts". International Journal of Molecular Sciences 21 23 (2020): 9168-9168. http://dx.doi.org/10.3390/ijms21239168.
    10.3390/ijms21239168
  13. Ayca Yildiz-Peköz; Carsten Ehrhardt. "Advances in Pulmonary Drug Delivery". Pharmaceutics (2020): https://doi.org/10.3390/pharmaceutics12100911.
    10.3390/pharmaceutics12100911
  14. Selo, Mohammed Ali; Delmas, Anne-Sophie; Springer, Lisa; Zoufal, Viktoria; Sake, Johannes A.; Clerkin, Caoimhe G.; Huwer, Hanno; et al. "Tobacco Smoke and Inhaled Drugs Alter Expression and Activity of Multidrug Resistance-Associated Protein-1 (MRP1) in Human Distal Lung Epithelial Cells in vitro". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.01030.
    10.3389/fbioe.2020.01030
  15. Mairinger, Severin; Sake, Johannes A.; Lozano, Irene Hernández; Filip, Thomas; Sauberer, Michael; Stanek, Johann; Wanek, Thomas; Ehrhardt, Carsten; Langer, Oliver. "Assessing the Activity of Multidrug Resistance–Associated Protein 1 at the Lung Epithelial Barrier". Journal of Nuclear Medicine 61 11 (2020): 1650-1657. http://dx.doi.org/10.2967/jnumed.120.244038.
    10.2967/jnumed.120.244038
  16. Johanna J. Salomon; Julia C. Gausterer; Mohammed Ali Selo; Ken-ichi Hosoya; Hanno Huwer; Nicole Schneider-Daum; Claus-Michael Lehr; Carsten Ehrhardt. "OCTN2-Mediated Acetyl-l-Carnitine Transport in Human Pulmonary Epithelial Cells In Vitro". Pharmaceutics (2019): https://doi.org/10.3390/pharmaceutics11080396.
    10.3390/pharmaceutics11080396
  17. Lili Duse; Michael Rene Agel; Shashank Reddy Pinnapireddy; Jens Schäfer; Mohammed A. Selo; Carsten Ehrhardt; Udo Bakowsky. "Photodynamic Therapy of Ovarian Carcinoma Cells with Curcumin-Loaded Biodegradable Polymeric Nanoparticles". Pharmaceutics (2019): https://doi.org/10.3390/pharmaceutics11060282.
    10.3390/pharmaceutics11060282
  18. Alhayali, Amani; Selo, Mohammed Ali; Ehrhardt, Carsten; Velaga, Sitaram. "Investigation of supersaturation and in vitro permeation of the poorly water soluble drug ezetimibe". European Journal of Pharmaceutical Sciences 117 (2018): 147-153. http://dx.doi.org/10.1016/j.ejps.2018.01.047.
    10.1016/j.ejps.2018.01.047
  19. Carsten Ehrhardt. "Inhalation Biopharmaceutics: Progress Towards Comprehending the Fate of Inhaled Medicines". Pharmaceutical Research 34 12 (2017): 2451-2453. https://doi.org/10.1007/s11095-017-2304-2.
    10.1007/s11095-017-2304-2
  20. Sabrina Nickel; Mohammed Ali Selo; Juliane Fallack; Caoimhe G. Clerkin; Hanno Huwer; Nicole Schneider-Daum; Claus-Michael Lehr; Carsten Ehrhardt. "Expression and Activity of Breast Cancer Resistance Protein (BCRP/ABCG2) in Human Distal Lung Epithelial Cells In Vitro". Pharmaceutical Research 34 12 (2017): 2477-2487. https://doi.org/10.1007/s11095-017-2172-9.
    10.1007/s11095-017-2172-9
  21. de Kruijf, Wilbur; Ehrhardt, Carsten. "Inhalation delivery of complex drugs — the next steps". Current Opinion in Pharmacology 36 (2017): 52-57. http://dx.doi.org/10.1016/j.coph.2017.07.015.
    10.1016/j.coph.2017.07.015
  22. Gukasyan, Hovhannes J.; Uchiyama, Tomomi; Kim, Kwang-Jin; Ehrhardt, Carsten; Wu, Sharon K.; Borok, Zea; Crandall, Edward D.; Lee, Vincent H.L.. "Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2". Pharmaceutical Research 34 12 (2017): 2488-2497. http://dx.doi.org/10.1007/s11095-017-2234-z.
    10.1007/s11095-017-2234-z
  23. Hu, Xiao; Yang, Fei-Fei; Liu, Chun-Yu; Ehrhardt, Carsten; Liao, Yong-Hong. "In vitro uptake and transport studies of PEG-PLGA polymeric micelles in respiratory epithelial cells". European Journal of Pharmaceutics and Biopharmaceutics 114 (2017): 29-37. http://dx.doi.org/10.1016/j.ejpb.2017.01.004.
    10.1016/j.ejpb.2017.01.004
  24. Tega, Yuma; Yuzurihara, Chihiro; Kubo, Yoshiyuki; Akanuma, Shin-ichi; Ehrhardt, Carsten; Hosoya, Ken-ichi; Tega, Y.; et al. "Functional expression of nicotine influx transporter in A549 human alveolar epithelial cells". Drug Metabolism and Pharmacokinetics 31 1 (2016): 99-101. http://dx.doi.org/10.1016/j.dmpk.2015.11.006.
    10.1016/j.dmpk.2015.11.006
  25. Tewes, F.; Gobbo, O.L.; Ehrhardt, C.; Healy, A.M.. "Amorphous Calcium Carbonate Based-Microparticles for Peptide Pulmonary Delivery". ACS Applied Materials and Interfaces 8 2 (2016): 1164-1175. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955504269&partnerID=MN8TOARS.
    10.1021/acsami.5b09023
  26. Zelikin, A.N.; Ehrhardt, C.; Healy, A.M.. "Materials and methods for delivery of biological drugs". Nature Chemistry 8 11 (2016): 997-1007. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992374796&partnerID=MN8TOARS.
    10.1038/nchem.2629
  27. Nickel, S.; Clerkin, C.G.; Selo, M.A.; Ehrhardt, C.. "Transport mechanisms at the pulmonary mucosa: Implications for drug delivery". Expert Opinion on Drug Delivery 13 5 (2016): 667-690. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959064031&partnerID=MN8TOARS.
    10.1517/17425247.2016.1140144
  28. Salomon, J.J.; Gausterer, J.C.; Yahara, T.; Hosoya, K.-I.; Huwer, H.; Hittinger, M.; Schneider-Daum, N.; Lehr, C.-M.; Ehrhardt, C.. "Organic cation transporter function in different in vitro models of human lung epithelium". European Journal of Pharmaceutical Sciences 80 (2015): 82-88. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944515317&partnerID=MN8TOARS.
    10.1016/j.ejps.2015.08.007
  29. Schwagerus, E.; Sladek, S.; Buckley, S.T.; Armas-Capote, N.; de la Rosa, D.A.; Harvey, B.J.; Fischer, H.; et al. "Expression and function of the epithelial sodium channel d-subunit in human respiratory epithelial cells in vitro". Pflugers Archiv European Journal of Physiology 467 11 (2015): 2257-2273. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943816112&partnerID=MN8TOARS.
    10.1007/s00424-015-1693-5
  30. Holmes, M.S.; Seheult, J.N.; O'Connell, P.; D'Arcy, S.; Ehrhardt, C.; Healy, A.M.; Costello, R.W.; Reilly, R.B.. "An Acoustic-Based Method to Detect and Quantify the Effect of Exhalation into a Dry Powder Inhaler". Journal of Aerosol Medicine and Pulmonary Drug Delivery 28 4 (2015): 247-253. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938373001&partnerID=MN8TOARS.
    10.1089/jamp.2014.1169
  31. Takano, M.; Sugimoto, N.; Ehrhardt, C.; Yumoto, R.. "Functional Expression of PEPT2 in the Human Distal Lung Epithelial Cell Line NCl-H441". Pharmaceutical Research 32 12 (2015): 3916-3926. http://www.scopus.com/inward/record.url?eid=2-s2.0-84945909604&partnerID=MN8TOARS.
    10.1007/s11095-015-1751-x
  32. Salomon, J.J.; Hagos, Y.; Petzke, S.; Kühne, A.; Gausterer, J.C.; Hosoya, K.-I.; Ehrhardt, C.. "Beta-2 Adrenergic Agonists Are Substrates and Inhibitors of Human Organic Cation Transporter 1". Molecular Pharmaceutics 12 8 (2015): 2633-2641. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938335051&partnerID=MN8TOARS.
    10.1021/mp500854e
  33. Amaro, M.I.; Tewes, F.; Gobbo, O.; Tajber, L.; Corrigan, O.I.; Ehrhardt, C.; Healy, A.M.. "Formulation, stability and pharmacokinetics of sugar-based salmon calcitonin-loaded nanoporous/nanoparticulate microparticles (NPMPs) for inhalation". International Journal of Pharmaceutics 483 1-2 (2015): 6-18. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922587412&partnerID=MN8TOARS.
    10.1016/j.ijpharm.2015.02.003
  34. Tewes, F.; Ehrhardt, C.; Healy, A.M.. "Superparamagnetic iron oxide nanoparticles (SPIONs)-loaded Trojan microparticles for targeted aerosol delivery to the lung". European Journal of Pharmaceutics and Biopharmaceutics 86 1 (2014): 98-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896732597&partnerID=MN8TOARS.
    10.1016/j.ejpb.2013.09.004
  35. Salomon, J.J.; Muchitsch, V.E.; Gausterer, J.C.; Schwagerus, E.; Huwer, H.; Daum, N.; Lehr, C.-M.; Ehrhardt, C.. "The cell line NCl-H441 is a useful in vitro model for transport studies of human distal lung epithelial barrier". Molecular Pharmaceutics 11 3 (2014): 995-1006. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901743670&partnerID=MN8TOARS.
    10.1021/mp4006535
  36. Seheult, J.N.; O'Connell, P.; Tee, K.C.; Bholah, T.; Al Bannai, H.; Sulaiman, I.; MacHale, E.; et al. "The acoustic features of inhalation can be used to quantify aerosol delivery from a Diskus™ dry powder inhaler". Pharmaceutical Research 31 10 (2014): 2735-2747. http://www.scopus.com/inward/record.url?eid=2-s2.0-84931090361&partnerID=MN8TOARS.
    10.1007/s11095-014-1371-x
  37. Salomon, J.J.; Ehrhardt, C.; Hosoya, K.-I.. "The verapamil transporter expressed in human alveolar epithelial cells (A549) does not interact with ß2- receptor agonists". Drug Metabolism and Pharmacokinetics 29 1 (2014): 101-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898438269&partnerID=MN8TOARS.
    10.2133/dmpk.DMPK-13-SH-026
  38. Hu, X.; Yang, F.-F.; Quan, L.-H.; Liu, C.-Y.; Liu, X.-M.; Ehrhardt, C.; Liao, Y.-H.. "Pulmonary delivered polymeric micelles - Pharmacokinetic evaluation and biodistribution studies". European Journal of Pharmaceutics and Biopharmaceutics 88 3 (2014): 1064-1075. http://www.scopus.com/inward/record.url?eid=2-s2.0-84912525231&partnerID=MN8TOARS.
    10.1016/j.ejpb.2014.10.010
  39. Swaminathan, J.; Gobbo, O.L.; Tewes, F.; Healy, A.M.; Ehrhardt, C.. "Encapsulation into PEG-liposomes does not improve the bioavailability of pulmonary delivered salmon calcitonin". Journal of Aerosol Medicine and Pulmonary Drug Delivery 27 1 (2014): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-84893096818&partnerID=MN8TOARS.
    10.1089/jamp.2013.1049
  40. Swaminathan, J.; Ehrhardt, C.. "Effect of lyophilization on liposomal encapsulation of salmon calcitonin". Journal of Liposome Research 24 4 (2014): 297-303. http://www.scopus.com/inward/record.url?eid=2-s2.0-84911500743&partnerID=MN8TOARS.
    10.3109/08982104.2014.899366
  41. Paszko, E.; Vaz, G.M.F.; Ehrhardt, C.; Senge, M.O.. "Transferrin conjugation does not increase the efficiency of liposomal Foscan during in vitro photodynamic therapy of oesophageal cancer". European Journal of Pharmaceutical Sciences 48 1-2 (2013): 202-210. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870381703&partnerID=MN8TOARS.
    10.1016/j.ejps.2012.10.018
  42. Chadderton, N.; Palfi, A.; Millington-Ward, S.; Gobbo, O.; Overlack, N.; Carrigan, M.; O'Reilly, M.; et al. "Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy". European Journal of Human Genetics 21 1 (2013): 62-68. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871188632&partnerID=MN8TOARS.
    10.1038/ejhg.2012.112
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  50. Baginski, L.; Gobbo, O.L.; Tewes, F.; Salomon, J.J.; Healy, A.M.; Bakowsky, U.; Ehrhardt, C.. "In vitro and in vivo characterisation of PEG-lipid-based micellar complexes of salmon calcitonin for pulmonary delivery". Pharmaceutical Research 29 6 (2012): 1425-1434. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862684995&partnerID=MN8TOARS.
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  56. Salomon, J.J.; Endter, S.; Tachon, G.; Falson, F.; Buckley, S.T.; Ehrhardt, C.. "Transport of the fluorescent organic cation 4-(4-(dimethylamino)styryl)-N- methylpyridinium iodide (ASP+) in human respiratory epithelial cells". European Journal of Pharmaceutics and Biopharmaceutics 81 2 (2012): 351-359. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861624577&partnerID=MN8TOARS.
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  57. Tewes, F.; Gobbo, O.L.; Amaro, M.I.; Tajber, L.; Corrigan, O.I.; Ehrhardt, C.; Healy, A.M.. "Evaluation of HPßCD-PEG microparticles for salmon calcitonin administration via pulmonary delivery". Molecular Pharmaceutics 8 5 (2011): 1887-1898. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053542504&partnerID=MN8TOARS.
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  58. Buckley, S.T.; Medina, C.; Kasper, M.; Ehrhardt, C.. "Interplay between RAGE, CD44, and focal adhesion molecules in epithelial-mesenchymal transition of alveolar epithelial cells". American Journal of Physiology - Lung Cellular and Molecular Physiology 300 4 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79955069042&partnerID=MN8TOARS.
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  60. Paszko, E.; Ehrhardt, C.; Senge, M.O.; Kelleher, D.P.; Reynolds, J.V.. "Nanodrug applications in photodynamic therapy". Photodiagnosis and Photodynamic Therapy 8 1 (2011): 14-29. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951580228&partnerID=MN8TOARS.
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  63. Buckley, S.T.; Medina, C.; Ehrhardt, C.. "Differential susceptibility to epithelial-mesenchymal transition (EMT) of alveolar, bronchial and intestinal epithelial cells in vitro and the effect of angiotensin II receptor inhibition". Cell and Tissue Research 342 1 (2010): 39-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957705072&partnerID=MN8TOARS.
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  70. Passante, E.; Ehrhardt, C.; Sheridan, H.; Frankish, N.. "RBL-2H3 cells are an imprecise model for mast cell mediator release". Inflammation Research 58 9 (2009): 611-618. http://www.scopus.com/inward/record.url?eid=2-s2.0-68449097464&partnerID=MN8TOARS.
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  71. Doolan, P.; Clynes, M.; Kennedy, S.; Mehta, J.P.; Germano, S.; Ehrhardt, C.; Crown, J.; O'Driscoll, L.. "TMEM25, REPS2 and Meis 1: Favourable prognostic and predictive biomarkers for breast cancer". Tumor Biology 30 4 (2009): 200-209. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349258430&partnerID=MN8TOARS.
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  77. Becker, U.; Ehrhardt, C.; Schneider, M.; Muys, L.; Gross, D.; Eschmann, K.; Schaefer, U.F.; Lehr, C.-M.. "A comparative evaluation of corneal epithelial cell cultures for assessing ocular permeability". ATLA Alternatives to Laboratory Animals 36 1 (2008): 33-44. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149165232&partnerID=MN8TOARS.
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  80. Bakowsky, H.; Richter, T.; Kneuer, C.; Hoekstra, D.; Rothe, U.; Bendas, G.; Ehrhardt, C.; Bakowsky, U.. "Adhesion characteristics and stability assessment of lectin-modified liposomes for site-specific drug delivery". Biochimica et Biophysica Acta - Biomembranes 1778 1 (2008): 242-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-38349074292&partnerID=MN8TOARS.
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  81. Sheridan, H.; Hook, I.; Nestor, C.; Coppins, J.; Ehrhardt, C.; Frankish, N.. "Inhibition of LFA-1 mediated T-cell motility by naphthoquinones". Planta Medica 74 11 (2008): 1383-1387. http://www.scopus.com/inward/record.url?eid=2-s2.0-52949099535&partnerID=MN8TOARS.
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  82. Steimer, A.; Franke, H.; Haltner-Ukomado, E.; Laue, M.; Ehrhardt, C.; Lehr, C.-M.. "Monolayers of porcine alveolar epithelial cells in primary culture as an in vitro model for drug absorption studies". European Journal of Pharmaceutics and Biopharmaceutics 66 3 (2007): 372-382. http://www.scopus.com/inward/record.url?eid=2-s2.0-34248526070&partnerID=MN8TOARS.
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  83. Endter, S.; Becker, U.; Daum, N.; Huwer, H.; Lehr, C.-M.; Gumbleton, M.; Ehrhardt, C.. "P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers". Cell and Tissue Research 328 1 (2007): 77-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947104217&partnerID=MN8TOARS.
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  88. Kneuer, G.; Ehrhardt, C.; Bakowsky, H.; Kumar, M.N.V.R.; Oberle, V.; Lehr, C.M.; Hoekstra, D.; Bakowsky, U.. "The influence of physicochemical parameters on the efficacy of non-viral DNA transfection complexes: A comparative study". Journal of Nanoscience and Nanotechnology 6 9-10 (2006): 2776-2782. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750077293&partnerID=MN8TOARS.
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  92. Ehrhardt, C.; Collnot, E.-M.; Baldes, C.; Becker, U.; Laue, M.; Kim, K.-J.; Lehr, C.-M.. "Towards an in vitro model of cystic fibrosis small airway epithelium: Characterisation of the human bronchial epithelial cell line CFBE41o-". Cell and Tissue Research 323 3 (2006): 405-415. http://www.scopus.com/inward/record.url?eid=2-s2.0-32444436992&partnerID=MN8TOARS.
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  96. Becker, U.; Ehrhardt, C.; Schaefer, U.F.; Gukasyan, H.J.; Kim, K.-J.; Lee, V.H.L.; Lehr, C.-M.. "Tissue distribution of moxaverine-hydrochloride in the rabbit eye and plasma". Journal of Ocular Pharmacology and Therapeutics 21 3 (2005): 210-216. http://www.scopus.com/inward/record.url?eid=2-s2.0-21644467787&partnerID=MN8TOARS.
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Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2019/03 - 2023 Exploring membrane transporters in lung epithelial cells: drug-transporter interaction analyses in different in vitro models
Orientador
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
2014/09 - 2018/09 The role of drug transporters in chronic obstructive pulmonary disease
Orientador
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
2014/09 - 2018/09 Characterisation of the functional role of OCTN1 in the pathogenesis of COPD
Orientador
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
2012/04 - 2016/08 Desenvolvimento de sistemas particulados contendo fármacos para administração pulmonar preparados por spray-drying
Coorientador
Universidade Federal do Rio Grande do Sul, Brasil
2008/04 - 2013/04 Investigation of novel photosensitisers for photodynamic cancer therapy
Coorientador
Trinity College Dublin School of Chemistry, Irlanda
2009/04 - 2012/10 Functional expression of the epithelial sodium channel d-subunit in human respiratory epithelial cells
Orientador
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
2009/03 - 2012/10 Drug transport across the human respiratory epithelial cell barrier
Orientador
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
2008/08 - 2011/12 Liposomes as carriers for systemic delivery of salmon calcitonin by inhalation
Orientador
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
2007/10 - 2010/09 Optimisation of pulmonary drug delivery of the model peptide drug salmon calcitonin
Orientador
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
2007/10 - 2010/09 Cytokine-induced epithelial-mesenchymal transition: mechanisms and implications for fibrotic diseases of respiratory and intestinal epithelia
Orientador
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
2005/10 - 2010/01 Characterisation of drug transporters in human respiratory epithelial cells
Orientador
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
2004/10 - 2009/10 In vitro investigation of the potential anti-inflammatory properties of novel compounds with respect to LFA-1 mediated T cell motility and cytotoxicity profiling
Coorientador
Trinity College Dublin School of Pharmacy and Pharmaceutical Sciences, Irlanda
2002/08 - 2006/12 Examination of the penetration behaviour of pharmaceuticals in the eye and establishment of an in vitro cell culture model for ocular drug delivery
Orientador
Universität des Saarlandes, Alemanha
2002/08 - 2006/09 Liposomal drug carrier systems for inhalation treatment of lung cancer
Orientador
Universität des Saarlandes, Alemanha