Francisco Corzana (B31F-8B04-31AC)

Curriculum Vitae

Francisco Corzana

Dr Francisco Corzana obtained his PhD in Chemistry from the University of La Rioja in 2001, with the main aim of producing enantioreins quaternary amino acids. He then completed 2 post-doctoral stays; one at the University of Copenhagen with Prof. Engelsen, where he worked on the study of the conformational behavior of starch-derived carbohydrates through Molecular Dynamics (MD) simulations, and another at the Centro de Investigaciones Biológicas (CSIC) in Madrid under the supervision of Prof. Jesús Jiménez Barbero and Juan Luis Asensio. During this post-doc, he carried out the synthesis of modified aminoglycoside antibiotics and performed their conformational analysis in solution, combining NMR experiments and MD simulations. In 2005, he returned to the University of La Rioja as a "Ramon y Cajal" researcher and has a permanent position at this university as an associate professor. His research focuses on the synthesis and structure of glycopeptides and their use in clinical applications, such as tumor detection and design of therapeutic vaccines for the treatment of cancer. Dr. Corzana is the PI of a European project at the University of La Rioja (DIRNANO. Curie ITN (H2020-MSCA-ITN-2020), reference: 956544). The main objective of this project is to develop a new generation of therapeutic vaccines. He was also the PI at the University of La Rioja of ProteinCojungates project (MSCA-ITN-2015-ETN. Reference: 675007). The main objective of this project was to develop a new generation of antibody-drug conjugates for the selective treatment of tumors. He has undertaken three short stays, one at the University of Oxford in 2012, with Prof. Ben Davis, to synthesize antifreeze-like glycopeptides and two stays at the University of Cambridge in 2014 and 2016, with Dr Bernardes, to work on selective protein chemical modifications. He has published more than 120 papers, including one Chem. Soc. Rev, 20 JACS, 8 ACIE, 4 Nat. Commun., 5 Chem. Sci. and 2 Nat. Chem. Biol. and one Chem, among others. Dr Corzana has given more than 20 invited talks at national and international conferences. He is currently a visiting professor at the University of Cambridge. He has 3 research periods of six years and has supervised 8 dissertations in the last 10 years. He is currently supervising 3 dissertations. He is the Administrator of Chemical Biology Group of Spanish Royal Society of Chemistry (2016-2019). He was recently highlighted as a "New Investigator in Glycoscience" in the journal Carbohydrate Research (Carbohydrate Research 2017, 445, 117-122.). He is the CTQ QMC Area Director of Science and Technical Coordination, Evaluation and Monitoring Division (2020-2023).

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Identificação

Identificação pessoal

Nome completo: Francisco Corzana

Nomes de citação

Corzana, Francisco

Identificadores de autor

Ciência ID: B31F-8B04-31AC
ORCID iD: 0000-0001-5597-8127

Endereços de correio eletrónico

francisco.corzana@unirioja.es (Profissional)

Moradas

Departamento de Química, Área de Química Orgánica; Facultad de Ciencia y Tecnología, Universidad de La Rioja; Madre de Dios, 51, 26006, Logroño, La Rioja, Espanha (Profissional)

Websites

https://www.francisco-corzana.com (Profissional)

Domínios de atuação

Ciências Exatas - Química - Química Orgânica
Ciências Exatas - Ciências da Computação e da Informação - Bioinformática

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Espanhol; Castelhano (Idioma materno)
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Alemão	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)	Utilizador proficiente (C1)

Formação

	Grau	Classificação
2001 Concluído	Doctorado en Química (Doctor of Philosophy) Universidad de la Rioja, Espanha
1996 Concluído	Licenciatura en Química (Bachelor) Universidad de la Rioja, Espanha

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2016/06/01 - 2016/08/31	Investigador (Investigação)	University of Cambridge Department of Chemistry, Reino Unido

2014/06/23 - 2014/08/31	Investigador (Investigação)	University of Cambridge Department of Chemistry, Reino Unido

2012/06/01 - 2012/08/31	Investigador (Investigação)	University of Cambridge Department of Chemistry, Reino Unido

2005 - 2009	Investigador (Investigação)	Universidad de la Rioja, Espanha

2003 - 2004	Pós-doutorado (Investigação)	Instituto de Química Orgánica General, Espanha

2001 - 2003	Pós-doutorado (Investigação)	Københavns Universitet - Frederiksberg Campus, Dinamarca

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2017 - Atual	Professor Catedrático (Docente Universitário)	Universidad de la Rioja, Espanha

2014 - Atual	Professor Visitante (Docente Universitário)	University of Cambridge, Reino Unido

2009 - 2017	Professor Catedrático (Docente Universitário)	Universidad de la Rioja, Espanha

2002 - 2003	Professor Auxiliar (Docente Universitário)	Københavns Universitet - Frederiksberg Campus, Dinamarca

Projetos

Bolsa

	Designação	Financiadores
2020/10/01 - 2024/10/10	Directing the immune response through designed nanomaterials. DIRNANO. Funding: 2,542,765E, reference: 956544. H2020-MSCA-ITN-2020 Investigador
2021/03/01 - 2024/02/29	Targeting human macrophage galactose C-type lectin towards the development of innovative and alternative cancer therapies PTDC/QUI-OUT/2586/2020 Investigador	Fundação para a Ciência e a Tecnologia
2020 - 2024	A training network for the chemical site-selective modification of proteins: Preparation of the next generation of therapeutic chemically defined protein conjugates. ProteinConjugates. Funding 4,027,501.44E (MSCA-ITN-2015-ETN), reference: 675007 Investigador
2019/01/01 - 2021/12/31	"Diseño estructural de (glico)peptidos y proteínas para terapia y diagnostico"; Funding 242K€ RTI2018-099592-B-C21 Investigador responsável Universidad de la Rioja, Espanha	Gobierno de España Ministerio de Ciencia e Innovación Em curso
2019 - 2021	Exploiting the use of unnatural glycopeptide-based antigens to detect and fight cancer. Ministerio de Ciencia, Innovación y Universidades. RTI2018-099592-B-C21. Funding 240.00K RTI2018-099592-B-C21 Investigador responsável
2018 - 2021	Design of new biosensors for early detection of cancer. Spanish Association against Cancer (AECC) 15/03/2018-31/01/2021 Investigador responsável
2015/10/01 - 2019/10/01	"A training network for the chemical site-selective modification of proteins: Preparation of the next generation of therapeutic chemically defined protein conjugates."; Funding 2.542.765€ MSCA-ITN-2015-ETN; 675007 Investigador responsável Universidad de la Rioja, Espanha	European Commission Concluído
2016/01/01 - 2018/12/31	"Diseño estructural de glicopéptidos de tipo mucina que incorporan miméticos del antígeno Tn para desarrollar biomarcadores y vacunas contra el cáncer"; Funding 168K€ CTQ2015-67727-R Investigador responsável Universidad de la Rioja, Espanha	Gobierno de España Ministerio de Economía y Empresa Concluído
2016/01/05 - 2018/06/05	"Espectroscopia RMN como herramienta de control de calidad y mejora en embutido curado"; Funding 75.914,33€ 2014-I-IDD-00142 Investigador Universidad de la Rioja, Espanha	Gobierno de La Rioja Agencia de Desarrollo Económico de la Rioja Concluído
2016 - 2018	Structural design of mucin-like glycopeptides incorporating mimicry of the antigen Tn to develop biomarkers and cancer vaccines. Funding 168K (MINECO)/FEDER. CTQ2015-67727-R Investigador responsável
2013/12/01 - 2015/12/31	"Sostenibilidad y mejora del equipamiento científico del centro de investigación en síntesis química (CISQ)"; Funding 404.872,70€ (MINECO)/FEDER. UNLR13-4E-1931 Investigador Universidad de la Rioja, Espanha	Gobierno de España Ministerio de Economía y Empresa Concluído
2013/01/01 - 2015/12/31	"Diseño racional de glicopéptidos con aplicaciones en Química Biológica"; Funding 182.520€ CTQ2012-36365 Investigador Universidad de la Rioja, Espanha	Gobierno de España Ministerio de Economía y Empresa Concluído
2010/01/01 - 2012/12/31	"Síntesis y análisis conformacional en agua de O-glicoaminoácidos y O-glicopéptidos modelo de interés biológico"; Funding 193.600,00€ CTQ2009-13814 Investigador Universidad de la Rioja, Espanha	Gobierno de España Ministerio de Ciencia e Innovación Concluído
1999 - 2012	More 20 projects as Researcher with the total Funding of 203.365 € and 12.338.563 pts. CTQ2006-05825/BQU CTQ2005-06235 CTQ2004-04494/BQU PB97-0998-C02-02 API-99/B02 API-00/B02 ACPI-2000 ANGI-2001/30 API-01/B02 API-05/B01 ANGI-2005/01 COLABORA 2007/18 EGI07/06 COLABORA 2008/18 EGI08/06 EGI10/65 COLABORA 2010/05 Investigador Universidad de la Rioja, Espanha	Concluído

Produções

Publicações

Artigo em revista

Lima, Carlos D. L.; Coelho, Helena; Gimeno, Ana; Trovão, Filipa; Diniz, Ana; Dias, Jorge S; Jiménez-Barbero, Jesús; et al. "Structural insights into the molecular recognition mechanism of the cancer and pathogenic epitope, LacdiNAc by immune-related lectins". Chemistry European Journal (2021):
Aceite para publicação
Adele Gabba; Agnieszka Bogucka; John G. Luz; Ana Diniz; Helena Coelho; Francisco Corzana; Francisco Javier Cañada; et al. "Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen". Biochemistry (2021): https://doi.org/10.1021/acs.biochem.1c00009.
10.1021/acs.biochem.1c00009
Díaz-Casado, Laura; Serrano-Chacón, Israel; Montalvillo-Jiménez, Laura; Corzana, Francisco; Bastida, Agatha; Santana, Andrés G.; González, Carlos; Asensio, Juan Luis. "De Novo Design of Selective Quadruplex–Duplex Junction Ligands and Structural Characterisation of Their Binding Mode: Targeting the G4 Hot-Spot". Chemistry – A European Journal (2021): http://dx.doi.org/10.1002/chem.202100456.
10.1002/chem.202100456
Aran Insausti; Elena R. Alonso; Belen Tercero; José I. Santos; Camilla Calabrese; Natalja Vogt; Francisco Corzana; et al. "Laboratory Observation of, Astrochemical Search for, and Structure of Elusive Erythrulose in the Interstellar Medium". The Journal of Physical Chemistry Letters (2021): 1352-1359. https://doi.org/10.1021/acs.jpclett.0c03050.
10.1021/acs.jpclett.0c03050
José, Maria; Faustino, Hélio; Coelho, Jaime; Vaz Pinto, Maria; Fernandes, Adelaide; companon, ismael; Corzana, Francisco; et al. "Efficient Amino-Sulfhydryl Stapling on Peptides and Proteins Using Bifunctional NHS-Activated Acrylamides". Angewandte Chemie International Edition (2021): http://dx.doi.org/10.1002/anie.202016936.
10.1002/anie.202016936
Díaz-Casado, Laura; Serrano-Chacón, Israel; Montalvillo-Jiménez, Laura; Corzana, Francisco; Bastida, Agatha; Santana, Andrés G.; González, Carlos; Asensio, Juan Luis. "De Novo Design of Selective Quadruplex–Duplex Junction Ligands and Structural Characterisation of Their Binding Mode: Targeting the G4 Hot-Spot". Chemistry – A European Journal (2021): http://dx.doi.org/10.1002/chem.202005026.
10.1002/chem.202005026
Sastre Toraño, Javier; Aizpurua-Olaizola, Oier; Wei, Na; Li, Tiehai; Unione, Luca; Jiménez-Osés, Gonzalo; Corzana, Francisco; et al. "Identification of Isomeric N -Glycans by Conformer Distribution Fingerprinting using Ion Mobility Mass Spectrometry". Chemistry – A European Journal 27 6 (2021): 2149-2154. http://dx.doi.org/10.1002/chem.202004522.
10.1002/chem.202004522
Kyle C. Martin; Jacopo Tricomi; Francisco Corzana; Ana García-García; Laura Ceballos-Laita; Thomas Hicks; Serena Monaco; et al. "Fucosyltransferase-specific inhibition via next generation of fucose mimetics". Chemical Communications (2021): https://doi.org/10.1039/D0CC04847J.
10.1039/D0CC04847J
Paula Oroz; Claudio D. Navo; Alberto Avenoza; Jesús H. Busto; Francisco Corzana; Gonzalo Jiménez-Osés; Jesús M. Peregrina. "Toward Enantiomerically Pure ß-Seleno-a-amino Acids via Stereoselective Se-Michael Additions to Chiral Dehydroalanines". Organic Letters (2020): https://doi.org/10.1021/acs.orglett.0c03832.
10.1021/acs.orglett.0c03832
Ana García-García; Laura Ceballos-Laita; Sonia Serna; Raik Artschwager; Niels C. Reichardt; Francisco Corzana; Ramon Hurtado-Guerrero. "Structural basis for substrate specificity and catalysis of a1,6-fucosyltransferase". Nature Communications (2020): https://doi.org/10.1038/s41467-020-14794-z.
10.1038/s41467-020-14794-z
Russo, Roberto; Padanha, Rita; Fernandes, Fábio; Veiros, Luis F.; Corzana, Francisco; Gois, Pedro M. P.. "Engineering Boron Hot Spots for the Site-Selective Installation of Iminoboronates on Peptide Chains". Chemistry – A European Journal 26 66 (2020): 15226-15231. http://dx.doi.org/10.1002/chem.202002675.
10.1002/chem.202002675
Jobst Liebau; Montse Tersa; Beatriz Trastoy; Joan Patrick; Ane Rodrigo-Unzueta; Francisco Corzana; Tobias Sparrman; Marcelo E. Guerin; Lena Mäler. "Unveiling the activation dynamics of a fold-switch bacterial glycosyltransferase by 19F NMR". Journal of Biological Chemistry 295 29 (2020): 9868-9878. https://doi.org/10.1074/jbc.RA120.014162.
10.1074/jbc.RA120.014162
Andrés G. Santana; Laura Montalvillo-Jiménez; Laura Díaz-Casado; Francisco Corzana; Pedro Merino; Francisco J. Cañada; Gonzalo Jiménez-Osés; et al. "Dissecting the Essential Role of Anomeric ß-Triflates in Glycosylation Reactions". Journal of the American Chemical Society (2020): https://doi.org/10.1021/jacs.0c05525.
10.1021/jacs.0c05525
Amedei, Amedeo; Asadzadeh, Fatemeh; Papi, Francesco; Vannucchi, Maria Giuliana; Ferrucci, Veronica; Bermejo, Iris A.; Fragai, Marco; et al. "A Structurally Simple Vaccine Candidate Reduces Progression and Dissemination of Triple-Negative Breast Cancer". iScience 23 6 (2020): 101250. http://dx.doi.org/10.1016/j.isci.2020.101250.
10.1016/j.isci.2020.101250
Mahú, Inês; Barateiro, Andreia; Rial-Pensado, Eva; Martinéz-Sánchez, Noelia; Vaz, Sandra H.; Cal, Pedro M.S.D.; Jenkins, Benjamin; et al. "Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects". Cell Metabolism 31 6 (2020): 1120-1135.e7. http://dx.doi.org/10.1016/j.cmet.2020.04.013.
10.1016/j.cmet.2020.04.013
Claudio D. Navo; Nuria Mazo; Paula Oroz; Marta I. Gutiérrez-Jiménez; Javier Marín; Juan Asenjo; Alberto Avenoza; et al. "Synthesis of Nß-Substituted a,ß-Diamino Acids via Stereoselective N-Michael Additions to a Chiral Bicyclic Dehydroalanine". The Journal of Organic Chemistry 85 5 (2020): 3134-3145. https://doi.org/10.1021/acs.joc.9b03020.
10.1021/acs.joc.9b03020
Camilla Calabrese; Iciar Uriarte; Aran Insausti; Montserrat Vallejo-López; Francisco J. Basterretxea; Stephen A. Cochrane; Benjamin G. Davis; Francisco Corzana; Emilio J. Cocinero. "Observation of the Unbiased Conformers of Putative DNA-Scaffold Ribosugars". ACS Central Science (2020): https://doi.org/10.1021/acscentsci.9b01277.
10.1021/acscentsci.9b01277
Enrique Gil de Montes; Alena Istrate; Claudio D. Navo; Ester Jiménez-Moreno; Emily A. Hoyt; Francisco Corzana; Inmaculada Robina; et al. "Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation". Angewandte Chemie International Edition (2020): https://doi.org/10.1002/anie.201914529.
10.1002/anie.201914529
Enrique Gil de Montes; Alena Istrate; Claudio D. Navo; Ester Jiménez-Moreno; Emily A. Hoyt; Francisco Corzana; Inmaculada Robina; et al. "Stable Pyrrole-Linked Bioconjugates through Tetrazine-Triggered Azanorbornadiene Fragmentation". Angewandte Chemie (2020): https://doi.org/10.1002/ange.201914529.
10.1002/ange.201914529
de las Rivas, Matilde; Paul Daniel, Earnest James; Narimatsu, Yoshiki; Compañón, Ismael; Kato, Kentaro; Hermosilla, Pablo; Thureau, Aurélien; et al. "Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3". Nature Chemical Biology 16 3 (2020): 351-360. http://dx.doi.org/10.1038/s41589-019-0444-x.
Publicado • 10.1038/s41589-019-0444-x
Mattia Ghirardello; Ane Ruiz-de-Angulo; Nagore Sacristan; Diego Barriales; Jesús Jiménez-Barbero; Ana Poveda; Francisco Corzana; Juan Anguita; Alberto Fernández-Tejada. "Exploiting structure–activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants". Chemical Communications (2020): https://doi.org/10.1039/C9CC07781B.
10.1039/C9CC07781B
Macías-León, Javier; Bermejo, Iris A.; Asín, Alicia; García-García, Ana; Compañón, Ismael; Jiménez-Moreno, Ester; Coelho, Helena; et al. "Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody". Chemical Communications 56 96 (2020): 15137-15140. http://dx.doi.org/10.1039/d0cc06349e.
10.1039/d0cc06349e
Diniz, Ana; Coelho, Helena; Dias, Jorge S.; Vliet, Sandra J.; Jiménez-Barbero, Jesús; Corzana, Francisco; Cabrita, Eurico J.; Marcelo, Filipa. "The Plasticity of the Carbohydrate Recognition Domain Dictates the Exquisite Mechanism of Binding of Human Macrophage Galactose-Type Lectin". Chemistry – A European Journal 25 61 (2019): 13945-13955. http://dx.doi.org/10.1002/chem.201902780.
Publicado • 10.1002/chem.201902780
Laura Montalvillo-Jiménez; Andrés G. Santana; Francisco Corzana; Gonzalo Jiménez-Osés; Jesús Jiménez-Barbero; Ana M. Gómez; Juan Luis Asensio. "Impact of Aromatic Stacking on Glycoside Reactivity: Balancing CH/p and Cation/p Interactions for the Stabilization of Glycosyl-Oxocarbenium Ions". Journal of the American Chemical Society (2019): https://doi.org/10.1021/jacs.9b03285.
10.1021/jacs.9b03285
Lindstedt, Philip R.; Aprile, Francesco A.; Matos, Maria J.; Perni, Michele; Bertoldo, Jean B.; Bernardim, Barbara; Peter, Quentin; et al. "Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification". ACS Central Science 5 8 (2019): 1417-1424. http://dx.doi.org/10.1021/acscentsci.9b00467.
Publicado • 10.1021/acscentsci.9b00467
Calabrese, Camilla; Écija, Patricia; Compañón, Ismael; Vallejo-López, Montserrat; Cimas, Álvaro; Parra, Maider; Basterretxea, Francisco J.; et al. "Conformational Behavior of d-Lyxose in Gas and Solution Phases by Rotational and NMR Spectroscopies". The Journal of Physical Chemistry Letters 10 12 (2019): 3339-3345. http://dx.doi.org/10.1021/acs.jpclett.9b00978.
Publicado • 10.1021/acs.jpclett.9b00978
Matos, Maria J.; Navo, Claudio D.; Hakala, Tuuli; Ferhati, Xhenti; Guerreiro, Ana; Hartmann, David; Bernardim, Barbara; et al. "Quaternization of Vinyl/Alkynyl Pyridine Enables Ultrafast Cysteine-Selective Protein Modification and Charge Modulation". Angewandte Chemie International Edition 58 20 (2019): 6640-6644. http://dx.doi.org/10.1002/anie.201901405.
Publicado • 10.1002/anie.201901405
José García-Jiménez, M.; Corzana, Francisco; De Paz, José L.; Nieto, Pedro M.. "Langerin-Heparin Interaction: Analysis of the Binding to the Non-Lectin Site". Natural Product Communications 14 5 (2019): 1934578X1985159. http://dx.doi.org/10.1177/1934578x19851597.
Publicado • 10.1177/1934578x19851597
Akkapeddi, Padma; Fragoso, Rita; Hixon, Julie A.; Ramalho, Ana Sofia; Oliveira, Mariana L.; Carvalho, Tânia; Gloger, Andreas; et al. "A fully human anti-IL-7Ra antibody promotes antitumor activity against T-cell acute lymphoblastic leukemia". Leukemia 33 9 (2019): 2155-2168. http://dx.doi.org/10.1038/s41375-019-0434-8.
Publicado • 10.1038/s41375-019-0434-8
Compañón, Ismael; Guerreiro, Ana; Mangini, Vincenzo; Castro-López, Jorge; Escudero-Casao, Margarita; Avenoza, Alberto; Busto, Jesús H.; et al. "Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage". Journal of the American Chemical Society 141 9 (2019): 4063-4072. http://dx.doi.org/10.1021/jacs.8b13503.
Publicado • 10.1021/jacs.8b13503
Filipa Marcelo; Nitin Supekar; Francisco Corzana; Joost C. van der Horst; Ilona M. Vuist; David Live; Geert-Jan P. H. Boons; David F. Smith; Sandra J. van Vliet. "Identification of a secondary binding site in human macrophage galactose-type lectin by microarray studies: Implications for the molecular recognition of its ligands". Journal of Biological Chemistry (2019): jbc.RA118.004957-jbc.RA118.004957. https://doi.org/10.1074/jbc.RA118.004957.
10.1074/jbc.RA118.004957
Barbara Bernardim; Maria J. Matos; Xhenti Ferhati; Ismael Compañón; Ana Guerreiro; Padma Akkapeddi; Antonio C. B. Burtoloso; et al. "Efficient and irreversible antibody–cysteine bioconjugation using carbonylacrylic reagents". Nature Protocols 14 1 (2019): 86-99. https://doi.org/10.1038/s41596-018-0083-9.
10.1038/s41596-018-0083-9
Corzana, Francisco. "Structure-Based Design of Potent Tumor-Associated Antigens: Modulation of Peptide Presentation by Single-Atom O/S or O/Se Substitutions at the Glycosidic Linkage". Journal of the American Chemical Society 141 9 (2019): 4063-4072. https://doi.org/10.1021/jacs.8b13503.
10.1021/jacs.8b13503
Navo, Claudio D.; Bermejo, Iris A.; Oroz, Paula; Tovillas, Pablo; Compañón, Ismael; Matías, Cristina; Avenoza, Alberto; et al. "Oxygen by Carbon Replacement at the Glycosidic Linkage Modulates the Sugar Conformation in Tn Antigen Mimics". ACS Omega 3 12 (2018): 18142-18152. http://dx.doi.org/10.1021/acsomega.8b02576.
Publicado • 10.1021/acsomega.8b02576
de las Rivas, Matilde; Paul Daniel, Earnest James; Coelho, Helena; Lira-Navarrete, Erandi; Raich, Lluis; Compañón, Ismael; Diniz, Ana; et al. "Structural and Mechanistic Insights into the Catalytic-Domain-Mediated Short-Range Glycosylation Preferences of GalNAc-T4". ACS Central Science 4 9 (2018): 1274-1290. http://dx.doi.org/10.1021/acscentsci.8b00488.
Publicado • 10.1021/acscentsci.8b00488
Latorre-Muro, Pedro; Baeza, Josue; Armstrong, Eric A.; Hurtado-Guerrero, Ramón; Corzana, Francisco; Wu, Lindsay E.; Sinclair, David A.; et al. "Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions". Molecular Cell 71 5 (2018): 718-732.e9. http://dx.doi.org/10.1016/j.molcel.2018.07.031.
Publicado • 10.1016/j.molcel.2018.07.031
Calloni, Ilaria; Unione, Luca; Jiménez-Osés, Gonzalo; Corzana, Francisco; Del Bino, Linda; Corrado, Alessio; Pitirollo, Olimpia; et al. "The Conformation of the Mannopyranosyl Phosphate Repeating Unit of the Capsular Polysaccharide of Neisseria meningitidis Serogroup A and Its Carba-Mimetic". European Journal of Organic Chemistry 2018 33 (2018): 4548-4555. http://dx.doi.org/10.1002/ejoc.201801003.
Publicado • 10.1002/ejoc.201801003
Claudio D. Navo; Alicia Asín; Eva Gómez-Orte; Marta I. Gutiérrez-Jiménez; Ismael Compañón; Begoña Ezcurra; Alberto Avenoza; et al. "Cell-Penetrating Peptides Containing Fluorescent d -Cysteines". Chemistry - A European Journal (2018): https://doi.org/10.1002/chem.201800603.
10.1002/chem.201800603
de las Rivas, Matilde; Coelho, Helena; Diniz, Ana; Lira-Navarrete, Erandi; Compañón, Ismael; Jiménez-Barbero, Jesús; Schjoldager, Katrine T.; et al. "Structural Analysis of a GalNAc-T2 Mutant Reveals an Induced-Fit Catalytic Mechanism for GalNAc-Ts". Chemistry - A European Journal 24 33 (2018): 8382-8392. http://dx.doi.org/10.1002/chem.201800701.
Publicado • 10.1002/chem.201800701
Pablo Tovillas; Iván García; Paula Oroz; Nuria Mazo; Alberto Avenoza; Francisco Corzana; Gonzalo Jiménez-Osés; Jesús H. Busto; Jesús M. Peregrina. "Tn Antigen Mimics by Ring-Opening of Chiral Cyclic Sulfamidates with Carbohydrate C1-S- and C1-O-Nucleophiles". The Journal of Organic Chemistry 83 9 (2018): 4973-4980. https://doi.org/10.1021/acs.joc.7b03225.
10.1021/acs.joc.7b03225
Matos, Maria J.; Oliveira, Bruno L.; Martínez-Sáez, Nuria; Guerreiro, Ana; Cal, Pedro M. S. D.; Bertoldo, Jean; Maneiro, María; et al. "Chemo- and Regioselective Lysine Modification on Native Proteins". Journal of the American Chemical Society 140 11 (2018): 4004-4017. http://dx.doi.org/10.1021/jacs.7b12874.
Publicado • 10.1021/jacs.7b12874
Shuang Sun; Ismael Compañón; Nuria Martínez-Sáez; João D. Seixas; Omar Boutureira; Francisco Corzana; Gonçalo J. L. Bernardes. "Enhanced Permeability and Binding Activity of Isobutylene-Grafted Peptides". ChemBioChem (2018): https://doi.org/10.1002/cbic.201700586.
10.1002/cbic.201700586
Corzana, Francisco. "Water Sculpts the Distinctive Shapes and Dynamics of the Tumor-Associated Carbohydrate Tn Antigens: Implications for Their Molecular Recognition". Journal of the American Chemical Society 140 31 (2018): 9952-9960. https://doi.org/10.1021/jacs.8b04801.
10.1021/jacs.8b04801
Tiago Rodrigues; Markus Werner; Jakob Roth; Eduardo H. G. da Cruz; Marta C. Marques; Padma Akkapeddi; Susana A. Lobo; et al. "Machine intelligence decrypts ß-lapachone as an allosteric 5-lipoxygenase inhibitor". Chemical Science 9 34 (2018): 6899-6903. https://doi.org/10.1039/C8SC02634C.
10.1039/C8SC02634C
Allyson M. Freedy; Maria J. Matos; Omar Boutureira; Francisco Corzana; Ana Guerreiro; Padma Akkapeddi; Víctor J. Somovilla; et al. "Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation". Journal of the American Chemical Society 139 50 (2017): 18365-18375. https://doi.org/10.1021/jacs.7b10702.
10.1021/jacs.7b10702
Matilde de las Rivas; Erandi Lira-Navarrete; Earnest James Paul Daniel; Ismael Compañón; Helena Coelho; Ana Diniz; Jesús Jiménez-Barbero; et al. "The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences". Nature Communications 8 1 (2017): https://doi.org/10.1038/s41467-017-02006-0.
10.1038/s41467-017-02006-0
Martínez-Sáez, Nuria; Sun, Shuang; Oldrini, Davide; Sormanni, Pietro; Boutureira, Omar; Carboni, Filippo; Compañón, Ismael; et al. "Oxetane Grafts Installed Site-Selectively on Native Disulfides to Enhance Protein Stability and Activity In Vivo". Angewandte Chemie International Edition 56 47 (2017): 14963-14967. http://dx.doi.org/10.1002/anie.201708847.
Publicado • 10.1002/anie.201708847
Bertoldo, Jean B.; Rodrigues, Tiago; Dunsmore, Lavinia; Aprile, Francesco A.; Marques, Marta C.; Rosado, Leonardo A.; Boutureira, Omar; et al. "A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases". Chem 3 4 (2017): 665-677. http://dx.doi.org/10.1016/j.chempr.2017.07.009.
Publicado • 10.1016/j.chempr.2017.07.009
Omar Boutureira; Nuria Martínez-Sáez; Kevin M. Brindle; André A. Neves; Francisco Corzana; Gonçalo J. L. Bernardes. "Site-Selective Modification of Proteins with Oxetanes". Chemistry - A European Journal (2017): https://doi.org/10.1002%2Fchem.201700745.
10.1002/chem.201700745
Omar Boutureira; Nuria Martínez-Sáez; Kevin M. Brindle; André A. Neves; Francisco Corzana; Gonçalo J. L. Bernardes. "Frontispiece: Site-Selective Modification of Proteins with Oxetanes". Chemistry - A European Journal (2017):
10.1002/chem.201782762
Nuria Martínez-Sáez; Jesús M. Peregrina; Francisco Corzana. "Principles of mucin structure: implications for the rational design of cancer vaccines derived from MUC1-glycopeptides". Chemical Society Reviews (2017): https://doi.org/10.1039/C6CS00858E.
10.1039/C6CS00858E
Corzana, Francisco. "The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer". Journal of the American Chemical Society 139 50 (2017): 18255-18261. https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038620553&doi=10.1021%2fjacs.7b09447&partnerID=40&md5=b2b908599014f443f3f573bf6c92de29.
10.1021/jacs.7b09447
Barbara Bernardim; Pedro M.S.D. Cal; Maria J. Matos; Bruno L. Oliveira; Nuria Martínez-Sáez; Inês S. Albuquerque; Elizabeth Perkins; et al. "Stoichiometric and irreversible cysteine-selective protein modification using carbonylacrylic reagents". Nature Communications 7 1 (2016): https://doi.org/10.1038/ncomms13128.
10.1038/ncomms13128
Colomer, Juan P.; Fernández de Toro, Beatriz; Cañada, F. Javier; Corzana, Francisco; Jiménez Barbero, Jesús; Canales, Ángeles; Varela, Oscar. "Diastereomeric Glycosyl Sulfoxides Display Different Recognition Features versusE. coliß-Galactosidase". European Journal of Organic Chemistry 2016 30 (2016): 5117-5122. http://dx.doi.org/10.1002/ejoc.201600835.
Publicado • 10.1002/ejoc.201600835
Rodrigues, Tiago; Sieglitz, Florian; Somovilla, Víctor J.; Cal, Pedro M. S. D.; Galione, Antony; Corzana, Francisco; Bernardes, Gonçalo J. L.. "Unveiling (-)-Englerin A as a Modulator of L-Type Calcium Channels". Angewandte Chemie International Edition 55 37 (2016): 11077-11081. http://dx.doi.org/10.1002/anie.201604336.
Publicado • 10.1002/anie.201604336
Rojas-Ocáriz, Víctor; Compañón, Ismael; Aydillo, Carlos; Castro-Lo¿ez, Jorge; Jiménez-Barbero, Jesús; Hurtado-Guerrero, Ramón; Avenoza, Alberto; et al. "Design of a-S-Neoglycopeptides Derived from MUC1 with a Flexible and Solvent-Exposed Sugar Moiety". The Journal of Organic Chemistry 81 14 (2016): 5929-5941. http://dx.doi.org/10.1021/acs.joc.6b00833.
Publicado • 10.1021/acs.joc.6b00833
Rojas-Ocáriz, V.; Compañón, I.; Aydillo, C.; Castro-Lo¿ez, J.; Jiménez-Barbero, J.; Hurtado-Guerrero, R.; Avenoza, A.; et al. "Design of a-S-Neoglycopeptides Derived from MUC1 with a Flexible and Solvent-Exposed Sugar Moiety". Journal of Organic Chemistry 81 14 (2016): 5929-5941. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978517876&partnerID=MN8TOARS.
10.1021/acs.joc.6b00833
Martínez Sáez, Nuria; Supekar, NT; Wolfert, MA; Bermejo Ruiz, Iris Alicia; Hurtado-Guerrero, R; Asensio, JL; Jimenez-Barbero, J; et al. "Mucin architecture behind the immune response: design, evaluation and conformational analysis of an antitumor vaccine derived from an unnatural MUC1 fragment". Chemical Science 7 3 (2016): 2294-2301.
10.1039/c5sc04039f
Jiménez-Moreno, E.; Montalvillo-Jiménez, L.; Santana, A.G.; Gómez, A.M.; Jiménez-Osés, G.; Corzana, F.; Bastida, A.; et al. "Finding the Right Candidate for the Right Position: A Fast NMR-Assisted Combinatorial Method for Optimizing Nucleic Acids Binders". Journal of the American Chemical Society 138 20 (2016): 6463-6474. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971432370&partnerID=MN8TOARS.
10.1021/jacs.6b00328
Navo, C.D.; Corzana, F.; Sánchez-Fernández, E.M.; Busto, J.H.; Avenoza, A.; Zurbano, M.M.; Nanba, E.; et al. "Conformationally-locked C-glycosides: Tuning aglycone interactions for optimal chaperone behaviour in Gaucher fibroblasts". Organic and Biomolecular Chemistry 14 4 (2016): 1473-1484. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955485276&partnerID=MN8TOARS.
10.1039/c5ob02281a
Unione, L.; Ortega, G.; Mallagaray, A.; Corzana, F.; Pérez-Castells, J.; Canales, A.; Jiménez-Barbero, J.; Millet, O.. "Unraveling the Conformational Landscape of Ligand Binding to Glucose/Galactose-Binding Protein by Paramagnetic NMR and MD Simulations". ACS Chemical Biology 11 8 (2016): 2149-2157. http://www.scopus.com/inward/record.url?eid=2-s2.0-84983315198&partnerID=MN8TOARS.
10.1021/acschembio.6b00148
Valero-González, J.; Leonhard-Melief, C.; Lira-Navarrete, E.; Jiménez-Osés, G.; Hernández-Ruiz, C.; Pallarés, M.C.; Yruela, I.; et al. "A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2". Nature Chemical Biology 12 4 (2016): 240-246. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957678805&partnerID=MN8TOARS.
10.1038/nchembio.2019
Solera, C.; Macchione, G.; Maza, S.; Kayser, M.M.; Corzana, F.; de Paz, J.L.; Nieto, P.M.. "Chondroitin Sulfate Tetrasaccharides: Synthesis, Three-Dimensional Structure and Interaction with Midkine". Chemistry (Weinheim an der Bergstrasse, Germany) 22 7 (2016): 2356-2369. http://www.scopus.com/inward/record.url?eid=2-s2.0-84977454908&partnerID=MN8TOARS.
10.1002/chem.201504440
Walkowicz, W.E.; Fernández-Tejada, A.; George, C.; Corzana, F.; Jiménez-Barbero, J.; Ragupathi, G.; Tan, D.S.; Gin, D.Y.. "Quillaja saponin variants with central glycosidic linkage modifications exhibit distinct conformations and adjuvant activities". Chemical Science 7 3 (2016): 2371-2380. http://www.scopus.com/inward/record.url?eid=2-s2.0-84959422760&partnerID=MN8TOARS.
10.1039/c5sc02978c
Fernández, E.M.S.; Navo, C.D.; Martínez-Sáez, N.; Gonçalves-Pereira, R.; Somovilla, V.J.; Avenoza, A.; Busto, J.H.; et al. "Tn Antigen Mimics Based on sp²-Iminosugars with Affinity for an anti-MUC1 Antibody". Organic Letters 18 15 (2016): 3890-3893. http://www.scopus.com/inward/record.url?eid=2-s2.0-84981232791&partnerID=MN8TOARS.
10.1021/acs.orglett.6b01899
Gutiérrez-Jiménez, M.I.; Aydillo, C.; Navo, C.D.; Avenoza, A.; Corzana, F.; Jiménez-Osés, G.; Zurbano, M.M.; Busto, J.H.; Peregrina, J.M.. "Bifunctional Chiral Dehydroalanines for Peptide Coupling and Stereoselective S-Michael Addition". Organic Letters 18 12 (2016): 2796-2799. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975317301&partnerID=MN8TOARS.
10.1021/acs.orglett.6b00840
Jiménez-Moreno, E.; Jiménez-Osés, G.; Gómez, A.M.; Santana, A.G.; Corzana, F.; Bastida, A.; Jiménez-Barbero, J.; Asensio, J.L.. "A thorough experimental study of CH/p interactions in water: quantitative structure-stability relationships for carbohydrate/aromatic complexes". Chemical Science 6 11 (2015): 6076-6085. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944238673&partnerID=MN8TOARS.
10.1039/c5sc02108a
Madariaga, D.; Martinez-Sáez, N.; Somovilla, V.J.; Coelho, H.; Valero-González, J.; Castro-Lopez, J.; Asensio, J.L.; et al. "Detection of tumor-associated glycopeptides by Lectins: The peptide context modulates carbohydrate recognition". ACS Chemical Biology 10 3 (2015): 747-756. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925352558&partnerID=MN8TOARS.
10.1021/cb500855x
García-González, I.; Mata, L.; Corzana, F.; Jiménez-Osés, G.; Avenoza, A.; Busto, J.H.; Peregrina, J.M.. "Synthesis and conformational analysis of hybrid a/ß-dipeptides incorporating S-glycosyl-ß^2,2-amino acids". Chemistry - A European Journal 21 3 (2015): 1156-1168. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920829521&partnerID=MN8TOARS.
10.1002/chem.201405318
Mazo, N.; García-González, I.; Navo, C.D.; Corzana, F.; Jiménez-Osés, G.; Avenoza, A.; Busto, J.H.; Peregrina, J.M.. "Synthesis of Mixed a/ß^2,2-Peptides by Site-Selective Ring-Opening of Cyclic Quaternary Sulfamidates". Organic Letters 17 23 (2015): 5804-5807. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948798274&partnerID=MN8TOARS.
10.1021/acs.orglett.5b02927
Jiménez-Moreno, E.; Gómez, A.M.; Bastida, A.; Corzana, F.; Jiménez-Oses, G.; Jiménez-Barbero, J.; Asensio, J.L.. "Modulating Weak Interactions for Molecular Recognition: A Dynamic Combinatorial Analysis for Assessing the Contribution of Electrostatics to the Stability of CH-p Bonds in Water". Angewandte Chemie - International Edition (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84922569902&partnerID=MN8TOARS.
10.1002/anie.201411733
Ester Jiménez-Moreno; Gonzalo Jiménez-Osés; Ana M. Gómez; Andrés G. Santana; Francisco Corzana; Agatha Bastida; Jesus Jiménez-Barbero; Juan Luis Asensio. "A thorough experimental study of CH/p interactions in water: quantitative structure–stability relationships for carbohydrate/aromatic complexes". Chemical Science 6 11 (2015): 6076-6085. https://doi.org/10.1039/C5SC02108A.
10.1039/C5SC02108A
Lira-Navarrete, E.; De Las Rivas, M.; Compañón, I.; Pallarés, M.C.; Kong, Y.; Iglesias-Fernández, J.; Bernardes, G.J.L.; et al. "Dynamic interplay between catalytic and lectin domains of GalNAc-transferases modulates protein O-glycosylation". Nature Communications 6 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84929208855&partnerID=MN8TOARS.
10.1038/ncomms7937
Martínez-Sáez, N.; Castro-Lõpez, J.; Valero-González, J.; Madariaga, D.; Compañõn, I.; Somovilla, V.J.; Salvadõ, M.; et al. "Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody". Angewandte Chemie - International Edition 54 34 (2015): 9830-9834. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939000734&partnerID=MN8TOARS.
10.1002/anie.201502813
Rodríguez, F.; Corzana, F.; Avenoza, A.; Busto, J.H.; Peregrina, J.M.; Del Zurbano, M.M.. "Conformational preferences of Chiral acyclic homooligomeric ß2,2-Peptides". Current Topics in Medicinal Chemistry 14 10 (2014): 1225-1234. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903735778&partnerID=MN8TOARS.
10.2174/1568026614666140423101226
Lira-Navarrete, E.; Iglesias-Fernández, J.; Zandberg, W.F.; Compañón, I.; Kong, Y.; Corzana, F.; Pinto, B.M.; et al. "Substrate-guided front-face reaction revealed by combined structural snapshots and metadynamics for the polypeptide N-acetylgalactosaminyltransferase 2". Angewandte Chemie - International Edition 53 31 (2014): 8206-8210. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905366680&partnerID=MN8TOARS.
10.1002/anie.201402781
Somovilla, V.J.; Martínez-Sáez, N.; Fernández-Tejada, A.; De La Torre, B.G.; Andreu, D.; Jiménez-Barbero, J.; Asensio, J.L.; et al. "Conformational analysis of peptides and glycopeptides derived from the consensus sequence for ß-O-glucosylation". Current Topics in Medicinal Chemistry 14 23 (2014): 2712-2721. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926315516&partnerID=MN8TOARS.
Madariaga, D.; Martínez-Sáez, N.; Somovilla, V.J.; García-García, L.; Berbis, M.Á.; Valero-Gónzalez, J.; Martín-Santamaría, S.; et al. "Serine versus threonine glycosylation with a-o-GalNac: Unexpected selectivity in their molecular recognition with lectins". Chemistry - A European Journal 20 39 (2014): 12616-12627. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922568971&partnerID=MN8TOARS.
10.1002/chem.201403700
Aydillo, C.; Compañón, I.; Avenoza, A.; Busto, J.H.; Corzana, F.; Peregrina, J.M.; Zurbano, M.M.. "S-Michael additions to chiral dehydroalanines as an entry to glycosylated cysteines and a sulfa-tn antigen mimic". Journal of the American Chemical Society 136 2 (2014): 789-800. http://www.scopus.com/inward/record.url?eid=2-s2.0-84892712061&partnerID=MN8TOARS.
10.1021/ja411522f
Rojas, V.; Carreras, J.; Corzana, F.; Avenoza, A.; Busto, J.H.; Peregrina, J.M.. "Synthesis and conformational analysis of neoglycoconjugates derived from O- and S-glucose". Carbohydrate Research 373 (2013): 1-8. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875403673&partnerID=MN8TOARS.
10.1016/j.carres.2013.02.013
Santana, A.G.; Jiménez-Moreno, E.; Gómez, A.M.; Corzana, F.; González, C.; Jiménez-Oses, G.; Jiménez-Barbero, J.; Asensio, J.L.. "A dynamic combinatorial approach for the analysis of weak carbohydrate/aromatic complexes: Dissecting facial selectivity in CH/p stacking interactions". Journal of the American Chemical Society 135 9 (2013): 3347-3350. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874871838&partnerID=MN8TOARS.
10.1021/ja3120218
Muñoz-García, J.C.; Corzana, F.; De Paz, J.L.; Angulo, J.; Nieto, P.M.. "Conformations of the iduronate ring in short heparin fragments described by time-averaged distance restrained molecular dynamics". Glycobiology 23 11 (2013): 1220-1229. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885974880&partnerID=MN8TOARS.
10.1093/glycob/cwt058
Aydillo, C.; Navo, C.D.; Busto, J.H.; Corzana, F.; Zurbano, M.M.; Avenoza, A.; Peregrina, J.M.. "A double diastereoselective michael-type addition as an entry to conformationally restricted Tn antigen mimics". Journal of Organic Chemistry 78 21 (2013): 10968-10977. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887108285&partnerID=MN8TOARS.
10.1021/jo4019396
Jiménez-Moreno, E.; Gómez-Pinto, I.; Corzana, F.; Santana, A.G.; Revuelta, J.; Bastida, A.; Jiménez-Barbero, J.; González, C.; Asensio, J.L.. "Chemical interrogation of drug/RNA complexes: From chemical reactivity to drug design". Angewandte Chemie - International Edition 52 11 (2013): 3148-3151. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874863550&partnerID=MN8TOARS.
10.1002/anie.201209434
Corzana, F.; Monge, M.; Sánchez-Forcada, E.. "Size and shape assessment of organometallic gold(I) metallodendrimers through PGSE-NMR and molecular dynamics simulations". Inorganica Chimica Acta 380 1 (2012): 31-39. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856217663&partnerID=MN8TOARS.
10.1016/j.ica.2011.10.006
Rodríguez, F.; Somovilla, V.J.; Corzana, F.; Busto, J.H.; Avenoza, A.; Peregrina, P.J.M.. "Cyclohexane ring as a tool to select the presentation of the carbohydrate moiety in glycosyl amino acids". Chemistry - A European Journal 18 16 (2012): 5096-5104. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859589651&partnerID=MN8TOARS.
10.1002/chem.201103089
Matesanz, R.; Diaz, J.F.; Corzana, F.; Santana, A.G.; Bastida, A.; Asensio, J.L.. "Multiple keys for a single lock: The unusual structural plasticity of the nucleotidyltransferase (4')/kanamycin complex". Chemistry - A European Journal 18 10 (2012): 2875-2889. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857521070&partnerID=MN8TOARS.
10.1002/chem.201101888
Mata, L.; Avenoza, A.; Busto, J.H.; Corzana, F.; Peregrina, J.M.. "Quaternary chiral ß2,2-amino acids with pyridinium and imidazolium substituents". Chemistry - A European Journal 18 49 (2012): 15822-15830. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870038619&partnerID=MN8TOARS.
10.1002/chem.201202096
Corzana, F.; Busto, J.H.; Marcelo, F.; Garcíadeluis, M.; Asensio, J.L.; Martín-Santamaría, S.; Jiménez-Barbero, J.; Avenoza, A.; Peregrina, J.M.. "Engineering O-glycosylation points in non-extended peptides: Implications for the molecular recognition of short tumor-associated glycopeptides". Chemistry - A European Journal 17 11 (2011): 3105-3110. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952126046&partnerID=MN8TOARS.
10.1002/chem.201003124
Jiménez-Osés, G.; García, J.I.; Corzana, F.; Elguero, J.. "Accurate calculation of chemical shifts in highly dynamic H 2@C60 through an integrated quantum mechanics/molecular dynamics scheme". Organic Letters 13 10 (2011): 2528-2531. http://www.scopus.com/inward/record.url?eid=2-s2.0-79956106721&partnerID=MN8TOARS.
10.1021/ol2004116
Corzana, F.; Busto, J.H.; Marcelo, F.; García De Luis, M.; Asensio, J.L.; Martín-Santamaría, S.; Sáenz, Y.; et al. "Rational design of a Tn antigen mimic". Chemical Communications 47 18 (2011): 5319-5321. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954580576&partnerID=MN8TOARS.
10.1039/c1cc10192g
Corzana, F.; Fernández-Tejada, A.; Busto, J.H.; Joshi, G.; Davis, A.P.; Jiménez-Barbero, J.; Avenoza, A.; Peregrina, J.M.. "Molecular recognition of ß-O-GlcNAc glycopeptides by a lectin-like receptor: Binding modulation by the underlying ser or thr amino acids". ChemBioChem 12 1 (2011): 110-117. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650710694&partnerID=MN8TOARS.
10.1002/cbic.201000526
Vacas, T.; Corzana, F.; Jiménez-Osés, G.; González, C.; Gómez, A.M.; Bastida, A.; Revuelta, J.; Asensio, J.L.. "Role of aromatic rings in the molecular recognition of aminoglycoside antibiotics: Implications for drug design". Journal of the American Chemical Society 132 34 (2010): 12074-12090. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956071603&partnerID=MN8TOARS.
10.1021/ja1046439
Hendrickx, P.M.S.; Corzana, F.; Depraetere, S.; Tourwe, D.A.; Augustyns, K.; Martins, J.C.. "The use of time-averaged 3JHH Restrained molecular dynamics (tar-MD) simulations for the conformational analysis of five-membered ring systems: Methodology and applications". Journal of Computational Chemistry 31 3 (2010): 561-572. http://www.scopus.com/inward/record.url?eid=2-s2.0-75649102865&partnerID=MN8TOARS.
10.1002/jcc.21345
Avenoza, A.; Busto, J.H.; Canal, N.; Corzana, F.; Peregrina, J.M.; Pérez-Fernández, M.; Rodríguez, F.. "Cyclobutane amino acid analogues of furanomycin obtained by a formal [2 + 2] cycloaddition strategy promoted by methylaluminoxane". Journal of Organic Chemistry 75 3 (2010): 545-552. http://www.scopus.com/inward/record.url?eid=2-s2.0-75749129442&partnerID=MN8TOARS.
10.1021/jo9025258
Revuelta, J.; Corzana, F.; Bastida, A.; Asensio, J.L.. "The unusual nucleotide recognition properties of the resistance enzyme ANT(4'): Inorganic Tri/polyphosphate as a substrate for aminoglycoside inactivation". Chemistry - A European Journal 16 29 (2010): 8635-8640. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955144385&partnerID=MN8TOARS.
10.1002/chem.201000641
Díaz, M.D.; Palomino-Schätzlein, M.; Corzana, F.; Andreu, C.; Carbajo, R.J.; Del Olmo, M.; Canales-Mayordomo, A.; et al. "Antimicrobial Peptides and Their Superior Fluorinated Analogues: Structure-Activity Relationships as Revealed by NMR Spectroscopy and MD Calculations". ChemBioChem 11 17 (2010): 2424-2432. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649261564&partnerID=MN8TOARS.
10.1002/cbic.201000424
Corzana, F.; Busto, J.H.; De Luis, M.G.; Fernández-Tejada, A.; Rodríguez, F.; Jiménez-Barbero, J.; Avenoza, A.; Peregrina, J.M.. "Dynamics and hydration properties of small antifreeze-like glycopeptides containing non-natural amino acids". European Journal of Organic Chemistry 18 (2010): 3525-3542. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953284506&partnerID=MN8TOARS.
10.1002/ejoc.201000375
Revuelta, J.; Vacas, T.; Corzana, F.; Gonzalez, C.; Bastida, A.; Asensio, J.L.. "Structure-based design of highly crowded ribostamycin/kanamycin hybrids as a new family of antibiotics". Chemistry - A European Journal 16 10 (2010): 2986-2991. http://www.scopus.com/inward/record.url?eid=2-s2.0-77649222388&partnerID=MN8TOARS.
10.1002/chem.200903003
Torrado, M.; Revuelta, J.; Gonzalez, C.; Corzana, F.; Bastida, A.; Asensio, J.L.. "Role of conserved salt bridges in homeodomain stability and DNA binding". Journal of Biological Chemistry 284 35 (2009): 23765-23779. http://www.scopus.com/inward/record.url?eid=2-s2.0-69949155029&partnerID=MN8TOARS.
10.1074/jbc.M109.012054
Fernández-Tejada, A.; Corzana, F.; Busto, J.H.; Avenoza, A.; Peregrina, J.M.. "Stabilizing unusual conformations in small peptides and glucopeptides using a hydroxylated cyclobutane amino acid". Organic and Biomolecular Chemistry 7 14 (2009): 2885-2893. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650456422&partnerID=MN8TOARS.
10.1039/b907091p
Fernández-Tejada, A.; Corzana, F.; Busto, J.H.; Jiménez-Osés, G.; Jiménez-Barbero, J.; Avenoza, A.; Peregrina, J.M.. "Insights into the geometrical features underlying ß-O-GIcNAc glycosylation: Water pockets drastically modulate the interactions between the carbohydrate and the peptide backbone". Chemistry - A European Journal 15 30 (2009): 7297-7301. http://www.scopus.com/inward/record.url?eid=2-s2.0-67651033651&partnerID=MN8TOARS.
10.1002/chem.200901204
Corzana, F.; Busto, J.H.; De Luis, M.G.; Jiménez-Barbero, J.; Avenoza, A.; Peregrina, J.M.. "The nature and sequence of the amino acid aglycone strongly modulates the conformation and dynamics effects of Tn antigen's clusters". Chemistry - A European Journal 15 15 (2009): 3863-3874. http://www.scopus.com/inward/record.url?eid=2-s2.0-63849158824&partnerID=MN8TOARS.
10.1002/chem.200801777
Fernández-Tejada, A.; Corzana, F.; Busto, J.H.; Avenoza, A.; Peregrina, J.M.. "Conformational effects of the non-natural a-methylserine on small peptides and glycopeptides". Journal of Organic Chemistry 74 24 (2009): 9305-9313. http://www.scopus.com/inward/record.url?eid=2-s2.0-73149103487&partnerID=MN8TOARS.
10.1021/jo901988w
Zhang, Z.; McCallum, S.A.; Xie, J.; Nieto, L.; Corzana, F.; Jiménez-Barbero, J.; Chen, M.; Liu, J.; Linhardt, R.J.. "Solution structures of chemoenzymatically synthesized heparin and its precursors". Journal of the American Chemical Society 130 39 (2008): 12998-13007. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149158096&partnerID=MN8TOARS.
10.1021/ja8026345
Fernández-Tejada, A.; Corzana, F.; Busto, J.H.; Jiménez-Osés, G.; Peregrina, J.M.; Avenoza, A.. "Non-natural amino acids as modulating agents of the conformational space of model glycopeptides.". Chemistry (Weinheim an der Bergstrasse, Germany) 14 23 (2008): 7042-7058. http://www.scopus.com/inward/record.url?eid=2-s2.0-54749083043&partnerID=MN8TOARS.
10.1002/chem.200800460
Revuelta, J.; Vacas, T.; Torrado, M.; Corzana, F.; Gonzalez, C.; Jiménez-Barbero, J.; Menendez, M.; Bastida, A.; Asensio, J.L.. "NMR-based analysis of aminoglycoside recognition by the resistance enzyme ANT(4'): The pattern of OH/NH3+ substitution determines the preferred antibiotic binding mode and is critical for drug inactivation". Journal of the American Chemical Society 130 15 (2008): 5086-5103. http://www.scopus.com/inward/record.url?eid=2-s2.0-42149169026&partnerID=MN8TOARS.
10.1021/ja076835s
Corzana, F.; Busto, J.H.; Jiménez-Osés, G.; De Luis, M.G.; Asensio, J.L.; Jiménez-Barbero, J.; Peregrina, J.M.; Avenoza, A.. "Serine versus threonine glycosylation: The methyl group causes a drastic alteration on the carbohydrate orientation and on the surrounding water shell". Journal of the American Chemical Society 129 30 (2007): 9458-9467. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547683219&partnerID=MN8TOARS.
10.1021/ja072181b
Corzana, F.; Cuesta, I.; Freire, F.; Revuelta, J.; Torrado, M.; Bastida, A.; Jiménez-Barbero, J.; Asensio, J.L.. "The pattern of distribution of amino groups modulates the structure and dynamics of natural aminoglycosides: Implications for RNA recognition". Journal of the American Chemical Society 129 10 (2007): 2849-2865. http://www.scopus.com/inward/record.url?eid=2-s2.0-33947197265&partnerID=MN8TOARS.
10.1021/ja066348x
Freire, F.; Cuesta, I.; Corzana, F.; Revuelta, J.; González, C.; Hricovini, M.; Bastida, A.; Jiménez-Barbero, J.; Asensio, J.L.. "A simple NMR analysis of the protonation equilibrium that accompanies aminoglycoside recognition: Dramatic alterations in the neomycin-B protonation state upon binding to a 23-mer RNA aptamer". Chemical Communications 2 (2007): 174-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845784390&partnerID=MN8TOARS.
10.1039/b611597g
Bastida, A.; Hidalgo, A.; Chiara, J.L.; Torrado, M.; Corzana, F.; Pérez-Cañadillas, J.M.; Groves, P.; et al. "Exploring the use of conformationally locked aminoglycosides as a new strategy to overcome bacterial resistance". Journal of the American Chemical Society 128 1 (2006): 100-116. http://www.scopus.com/inward/record.url?eid=2-s2.0-30844466867&partnerID=MN8TOARS.
10.1021/ja0543144
Corzana, F.; Busto, J.H.; Jiménez-Osés, G.; Asensio, J.L.; Jiménez-Barbero, J.; Peregrina, J.M.; Avenoza, A.. "New insights into a-GalNAc-Ser motif: Influence of hydrogen bonding versus solvent interactions on the preferred conformation". Journal of the American Chemical Society 128 45 (2006): 14640-14648. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750970562&partnerID=MN8TOARS.
10.1021/ja064539u
Jiménez-Osés, G.; Corzana, F.; Busto, J.H.; Pérez-Fernández, M.; Peregrina, J.M.; Avenoza, A.. "Conformational analysis of 2-substituted cyclobutane-a-amino acid derivatives. A synergistic experimental and computational study". Journal of Organic Chemistry 71 5 (2006): 1869-1878. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644650028&partnerID=MN8TOARS.
10.1021/jo0521955
Corzana, F.; Busto, J.H.; Engelsen, S.B.; Jiménez-Barberó, J.; Asensio, J.L.; Peregrina, J.M.; Avenoza, A.. "Effect of ß-O-glucosylation on L-Ser and L-Thr diamides: A bias toward a-helical conformations". Chemistry - A European Journal 12 30 (2006): 7864-7871. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750374695&partnerID=MN8TOARS.
10.1002/chem.200600128
Corzana, F.; Cuesta, I.; Bastida, A.; Hidalgo, A.; Latorre, M.; González, C.; García-Junceda, E.; Jiménez-Barbero, J.; Asensio, J.L.. "Molecular recognition of aminoglycoside antibiotics by bacterial defence proteins: NMR study of the structural and conformational features of streptomycin inactivation by Bacillus subtilis aminoglycoside-6-adenyl transferase". Chemistry - A European Journal 11 17 (2005): 5102-5113. http://www.scopus.com/inward/record.url?eid=2-s2.0-24344463899&partnerID=MN8TOARS.
10.1002/chem.200400941
Martín-Pastor, M.; Canales, A.; Corzana, F.; Asensio, J.L.; Jiménez-Barbero, J.. "Limited flexibility of lactose detected from residual dipolar couplings using molecular dynamics simulations and steric alignment methods". Journal of the American Chemical Society 127 10 (2005): 3589-3595. http://www.scopus.com/inward/record.url?eid=2-s2.0-14944371866&partnerID=MN8TOARS.
10.1021/ja043445m
Avenoza, A.; Busto, J.H.; Corzana, F.; Peregrina, J.M.; Sucunza, D.; Zurbano, M.M.. "Diastereoselective synthesis of (S)- and (R)-a-phenylserine by a sulfinimine-mediated strecker reaction". Synthesis 4 (2005): 575-578. http://www.scopus.com/inward/record.url?eid=2-s2.0-15444379777&partnerID=MN8TOARS.
10.1055/s-2004-837308
Avenoza, A.; Busto, J.H.; Corzana, F.; Jiménez-Osés, G.; Peregrina, J.M.. "SN2 vs E2 on quaternary centers: An easy approach to chiral ß2,2-amino acids from cyclic sulfamidates". Phosphorus, Sulfur and Silicon and the Related Elements 180 5-6 (2005): 1459-1460. http://www.scopus.com/inward/record.url?eid=2-s2.0-27244458175&partnerID=MN8TOARS.
10.1080/10426500590913078
Asensio, J.L.; Hidalgo, A.; Bastida, A.; Torrado, M.; Corzana, F.; Chiara, J.L.; García-Junceda, E.; Cañada, J.; Jiménez-Barbero, J.. "A simple structural-based approach to prevent aminoglycoside inactivation by bacterial defense proteins. Conformational restriction provides effective protection against neomycin-B nucleotidylation by ANT4". Journal of the American Chemical Society 127 23 (2005): 8278-8279. http://www.scopus.com/inward/record.url?eid=2-s2.0-20444433905&partnerID=MN8TOARS.
10.1021/ja051722z
Avenoza, A.; Busto, J.H.; Corzana, F.; Peregrina, J.M.; Sucunza, D.; Zurbano, M.M.. "a-Methylserinals as an access to a-methyl-ß-hydroxyamino acids: Application in the synthesis of all stereoisomers of a- methylthreonine". Tetrahedron Asymmetry 15 4 (2004): 719-724. http://www.scopus.com/inward/record.url?eid=2-s2.0-1042275588&partnerID=MN8TOARS.
10.1016/j.tetasy.2003.12.001
Corzana, F.; Motawia, M.S.; Hervé du Penhoat, C.; Perez, S.; Tschampel, S.M.; Woods, R.J.; Engelsen, S.B.. "A Hydration Study of (1¿4) and (1¿6) Linked a-Glucans by Comparative 10 ns Molecular Dynamics Simulations and 500-MHz NMR". Journal of Computational Chemistry 25 4 (2004): 573-586. http://www.scopus.com/inward/record.url?eid=2-s2.0-1542285296&partnerID=MN8TOARS.
Avenoza, A.; Busto, J.H.; Corzana, F.; Jiménez-Osés, G.; París, M.; Peregrina, J.M.; Sucunza, D.; Zurbano, M.M.. "New syntheses of enantiopure 2-methyl isoserines". Tetrahedron Asymmetry 15 1 (2004): 131-137. http://www.scopus.com/inward/record.url?eid=2-s2.0-0346787777&partnerID=MN8TOARS.
10.1016/j.tetasy.2003.09.051
Avenoza, A.; Busto, J.H.; Corzana, F.; Jiménez-Osés, G.; Peregrina, J.M.. "SN2 vs. E2 on quaternary centres: An application to the synthesis of enantiopure ß2,2-amino acids". Chemical Communications 10 8 (2004): 980-981. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442473700&partnerID=MN8TOARS.
Corzana, F.; Motawia, M.S.; Hervé Du Penhoat, C.; Van Den Berg, F.; Blennow, A.; Perez, S.; Engelsen, S.B.. "Hydration of the amylopectin branch point. Evidence of restricted conformational diversity of the a-(1¿6) linkage". Journal of the American Chemical Society 126 40 (2004): 13144-13155. http://www.scopus.com/inward/record.url?eid=2-s2.0-5744228424&partnerID=MN8TOARS.
Avenoza, A.; Busto, J.H.; Corzana, F.; Peregrina, J.M.; Sucunza, D.; Zurbano, M.M.. "Diastereoselective synthesis of protected 4-epi-vancosamine from (S)-N-Boc-N,O-isopropylidene-a-methylserinal". Tetrahedron Asymmetry 14 8 (2003): 1037-1043. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037453330&partnerID=MN8TOARS.
10.1016/S0957-4166(03)00119-8
Avenoza, A.; Busto, J.H.; Corzana, F.; García, J.I.; Peregrina, J.M.. "Understanding the unusual regioselectivity in the nucleophilic ring-opening reactions of gem-disubstituted cyclic sulfates. Experimental and theoretical studies". Journal of Organic Chemistry 68 11 (2003): 4506-4513. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037764769&partnerID=MN8TOARS.
10.1021/jo034178q
Avenoza, A.; Busto, J.H.; Corzana, F.; Jiménez-Osés, G.; Peregrina, J.M.. "Conformational analysis of N-Boc-N,O-isopropylidene-a-serinals. A combined DFT and NMR study". Tetrahedron 59 30 (2003): 5713-5718. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037630621&partnerID=MN8TOARS.
10.1016/S0040-4020(03)00852-4
Corzana, F.; Bettler, E.; Du Penhoat, C.H.; Tyrtysh, T.V.; Bovin, N.V.; Imberty, A.. "Solution structure of two xenoantigens: aGal-LacNAc and aGal-Lewis X". Glycobiology 12 4 (2002): 241-250. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036019909&partnerID=MN8TOARS.
Avenoza, A.; Busto, J.H.; Cativiela, C.; Corzana, F.; Peregrina, J.M.; Zurbano, M.M.. "Asymmetric hetero Diels-Alder as an access to carbacephams". Journal of Organic Chemistry 67 2 (2002): 598-601. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037169120&partnerID=MN8TOARS.
10.1021/jo016186h
Avenoza, A.; Cativiela, C.; Corzana, F.; Peregrina, J.M.; Sucunza, D.; Zurbano, M.M.. "Enantioselective synthesis of (S)- and (R)-a-methylserines: Application to the synthesis of (S)- and (R)-N-Boc-N,O-isopropylidene-a-methylserinals". Tetrahedron Asymmetry 12 6 (2001): 949-957. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035902418&partnerID=MN8TOARS.
10.1016/S0957-4166(01)00159-8
Avenoza, A.; Cativiela, C.; Corzana, F.; Peregrina, J.M.; Zurbano, M.M.. "Asymmetric synthesis of all isomers of a-methyl-ß-phenylserine". Tetrahedron Asymmetry 11 10 (2000): 2195-2204. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034595642&partnerID=MN8TOARS.
10.1016/S0957-4166(00)00149-X
Avenoza, A.; Cativiela, C.; Corzana, F.; Peregrina, J.M.; Zurbano, M.M.. "Preparation and synthetic applications of (S)- and (R)-N-boc-N, O- isopropylidene-a-methylserinals: Asymmetric synthesis of (S)- and (R)-2- amino-2-methylbutanoic acids (Iva)". Journal of Organic Chemistry 64 22 (1999): 8220-8225. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033615484&partnerID=MN8TOARS.
10.1021/jo990957o
Avenoza, A.; Cativiela, C.; Corzana, F.; Peregrina, J.M.; Zurbano, M.M.. "Convenient procedures for the synthesis of N-BOC-D-serinal acetonide from L-serine". Synthesis 10 (1997): 1146-1150. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030818943&partnerID=MN8TOARS.

Poster em conferência

Corzana, Francisco. "Tumor targeted therapy with granulysin based immunotoxins". Trabalho apresentado em Cell Press Symposium “Hallmarks of Cancer”, Seattle (EE. UU.), 2019.
Corzana, Francisco. "The use of Grob fragmentation in controlled drug release". Trabalho apresentado em 2nd PSL Chemical Biology Symposium, Paris, France, 2019.
Corzana, Francisco. "Anti-tumoral potential of granulysin-containing protein products directed against the Tn antigen". Trabalho apresentado em 5th European Congress of Immunology, Amsterdam, The Netherlands, 2018.
Corzana, Francisco. "Chemistry behind the Immune Response for the Tn Antigen: The Role of the Presentation and Chemical Nature of the Partners". Trabalho apresentado em XXXV Reunión Bienal RSEQ, A Coruña, Spain, 2015.
Corzana, Francisco. "28 posters in different conferences from 2000-2015". 2000.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2020	More than 45 Oral Communications where 19 were invited, 2 plenary and 1 keynote lecture.
2019/06/03	"Modeling of biological systems by molecular dynamics (MD) simulations"	Introductory Workshop on Biomedical Glycoscience (San Sebastián, Espanha)
2019/05	"Structure-based design of potent tumor-associated mucin-like antigens by O¿S/Se replacement at the glycosidic linkage"	XXXVII Reunión Bienal Real Sociedad Española de Química (San Sebastián, Espanha)
2018/10	"Molecular basis for antigen recognition: applications for the development of new anticancer vaccines"	NUEVOS RETOS EN SÍNTESIS QUÍMICA III (Máster en Química Sintética e Industrial) (San Sebastián, Espanha)
2018/06	"The Use of Fluoroproline in MUC1 Antigen Enables Efficient Detection of Antibodies in Patients with Prostate Cancer"	II Annual Meeting CINBIO (Vigo, Espanha)
2018/04/06	"Fluoroproline in MUC1 antigen opens a new via in the development of enhanced cancer diagnostic tools"	International Wageningen Symposium on Organic Chemistry (Wageningen, Países Baixos)
2018/03	"Molecular Modelling & Protein-Sugar Interactions"	Glycovax Training Event IV (Bilbao, Espanha)
2018/02/08	"Bases supramoleculares del reconocimiento de antígenos: aplicaciones al desarrollo de nuevas vacunas contra el cáncer"	“50 años de Química Supramolecular" Real Sociedad Española de Química-Sección Territorial Aragón (Zaragoza, Espanha)
2017/10	"Design of novel glycopeptide-based cancer vaccines"	XL SEBBM Congress. The Annual Congress of the SFBBM (Barcelona, Espanha)
2017/07	"Effect of Glycosylation on Mucin-Like Peptides and Implications for Molecular Recognition by Antibodies"	19th European Carbohydrate Symposium – EUROCARB (Barcelona, Espanha)
2017/06	"Conformational study of DNA sugars: from the gas phase to solution"	72nd International Symposium on Molecular Spectroscopy (Illinois, Estados Unidos)
2017/06	"Design of novel glycopeptide-based cancer vaccines"	16th Spanish Biophysical Society (SBE) Congress Spanish Biophysical Society (Seville, Espanha)
2017/03	"Design of novel glycopeptide-based cancer vaccines"	Gycovax—Training Event II (Lisbon, Portugal)
2016/10/06	"Nuevas estrategias para el diseño de fármacos basadas en reacciones Orgánicas Clásicas"	Fronteras de la Química Real Sociedad Española de Química (Valencia, Espanha)
2016/09	"Oxetanes as new handles for protein and peptide stapling"	6th EuCheMS Chemistry Congress (Seville, Espanha)
2016/07	"Design of novel glycopeptide-based cancer vaccines" Plenary Oral Communication	11th Spanish-Italian Symposium on Chemistry/ SISOC XI (San Sebastián, Espanha)
2016/04/22	"tar-MD simulations to Study Flexible Molecules in Solution" Plenary Oral Communication	One-day Symposium on Computational Chemical Biology Honoring Ken Houk (Logroño, Espanha)
2016/03	"Design of novel cancer vaccines based on MUC1"	III Biennial Meeting of Chemical Biology Group / XII Carbohydrate Symposium (Madrid, Espanha)
2016/02	"Design of novel cancer vaccines based on MUC1"	VII International Conference on Molecular Recognition (Zaragoza, Espanha)
2015/09	"Molecular Dynamics simulations and NMR to study flexible molecules in solution"	GlycoBiology Summer School (Braga, Portugal)
2015/09	"Bicyclic C-glycosides as selective beta-glucosidase inhibitors: a new pharmacological chaperone for Gaucher's disease"	11th International Meeting of the Portuguese Carbohydrate Group – GLUPOR 11 – and 6th Iberian Carbohydrate Meeting (Viseu, Portugal)
2015/07	"A Chiral Dehydroalanine as Michael Acceptor in the Synthesis of Sulfa-TN Antigen" Flash Oral Communication	XXXV Reunión Bienal Real Sociedad Española de Química (A Coruña, Espanha)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2018/11/01 - Atual	MUC1 glycosylation mechanism by ST6GalNAc-I and C1-GalT1 Coorientador de Ana Sofia Grosso	Chemistry (Doutoramento) Universidade Nova de Lisboa Departamento de Química, Portugal Universidad de la Rioja, Espanha
2016 - 2020	"Reconocimiento Molecular de Análogos de Antígenos Tn como Base para el Diseño de Vacunas Terapéuticas contra el Cáncer" Orientador de Ismael Compañón	Chemistry (Doutoramento) Universidad de la Rioja, Espanha
2016 - 2019	"Design of smart linkers and their applications in controlled-release drug delivery systems" Orientador de Xhenti Ferhati	Chemistry (Doutoramento) Universidad de la Rioja, Espanha
2014 - 2018	"Structure-based design of glycopeptides featuring unnatural Tn antigens and their applications to cancer vaccination and diagnosis" Orientador de Iris Alicia Bermejo Ruiz	Chemistry (Doutoramento) Universidad de la Rioja, Espanha
2011 - 2015	"New Insights into Molecular Recognition of Epitopes Related to MUC1 Human Mucin by Lectins" Orientador de David Madariaga Merino	Chemistry (Doutoramento) Universidad de la Rioja Facultad de Ciencias Estudios Agroalimentarios e Informática, Espanha
2010 - 2014	"Síntesis y análisis conformacional de glicopéptidos que incorporan beta-glucosa y alfa-N-acetilgalactosamina" Orientador de Víctor J. Somovilla Busto	Chemistry (Doutoramento) Universidad de la Rioja Facultad de Ciencias Estudios Agroalimentarios e Informática, Espanha
2009 - 2013	"Diseño racional de derivados de mucina como candidatos a vacunas contra el cáncer" Orientador de Nuria Martínez Sáez	Chemistry (Doutoramento) Universidad de la Rioja Facultad de Ciencias Estudios Agroalimentarios e Informática, Espanha
2006 - 2009	"beta-O-glicosilación de péptidos que incorporan aminoácidos no naturales" Orientador de Alberto Fernández-Tejada	Chemistry (Doutoramento) Universidad de la Rioja Facultad de Ciencias Estudios Agroalimentarios e Informática, Espanha
2004 - 2008	"Glicopéptidos Modelo que incorporan el antígeno Tn. Síntesis y análisis conformacional" Orientador de María Luisa García de Luis	Chemistry (Doutoramento) Universidad de la Rioja Facultad de Ciencias Estudios Agroalimentarios e Informática, Espanha

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2017/06/25 - 2017/06/29	Determinantes estructurales de los procesos de reconocimiento molecular en moléculas biológicas”, dentro de la “XXXVI Reunión Bienal de la RSEQ” (2017/06/25 - 2017/06/29) Congresso (Membro da Comissão Organizadora)	Real Sociedad Espanola de Quimica, Espanha
2016/11/08 - 2016/11/11	XIII Simposio de Investigadores Jóvenes de la Real Sociedad Española de Química (2016/11/08 - 2016/11/11) Simpósio (Presidente da Comissão Organizadora)	Real Sociedad Espanola de Quimica, Espanha
2014/05/28 - 2014/05/30	XI Jornadas de Carbohidratos / XI Carbohydrate Symposium (2014/05/28 - 2014/05/30) Simpósio (Membro da Comissão Organizadora)

Arbitragem científica em conferência

	Nome da conferência	Local da conferência
2016/11/08 - 2016/11/11	XIII Simposio de Investigadores Jóvenes de la Real Sociedad Española de Química	Real Sociedad Española de Química
2015/10/06 - 2015/10/10	11th International Meeting of Portuguese Carbohydrate Chemistry Group. 6th Iberian Carbohydrate Meeting	Real Sociedad Portuguesa de Química
2014/05/28 - 2014/05/30	XI Jornadas de Carbohidratos / XI Carbohydrate Symposium

Membro de associação

	Nome da associação	Tipo de participação
2016/03 - 2019/06	Real Sociedad Española de Química	Secretario del Grupo Especializado en Química Biológica
2014/05 - 2016/06	Real Sociedad Española de Química	Tesorero del Grupo Especializado de Carbohidratos

Membro de comissão

	Descrição da atividade Tipo de participação	Instituição / Organização
2020 - 2023	CTQ QMC Area Director of Science and Technical Coordination, Evaluation and Monitoring Division	Spanish State Research Agency, Espanha

Distinções

Prémio

2017	Scientific trajectory featured in Carbohydrate Research (Carbohydr. Res. 2017, 445, 117–122)
2015	Best Thesis Prize to the PhD dissertation of Víctor J. Somovilla Busto
2012	Best Flash Oral Communication in Organic Chemistry at the 26th International Carbohydrate Symposium
2012	Best Oral Communication in Organic Chesmistry at the 26th International Carbohydrate Symposium
2010	Chosen by Real Sociedad Española de Química as one of the Spanish representatives in the congress “2nd EUCHEMs Organic Division Young Investigator Workshop (ODYI)” in Regensburg Real Sociedad Espanola de Quimica, Espanha

Outra distinção

2015	Research Stay of 3 months at University of Cambridge
2014	Research Stay of 2 months at University of Cambridge
2011	Research Stay of 3 months at University of Oxford