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Domingos Manuel Pinto Henrique. É Investigador Auxiliar (carreira) no(a) Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina da Universidade de Lisboa, assim como investigador do Instituto de Medicina Molecular. Publicou 83 artigos em revistas especializadas. Atua na(s) área(s) de Ciências Naturais com ênfase em Ciências Biológicas e em particular na Biologia do Desenvolvimento. Nas suas atividades profissionais interagiu com 284 colaborador(es) em coautorias de trabalhos científicos. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Notch signaling; Stem Cell; Neurogenesis; Neural development; Gene regulation; .
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Identificação

Identificação pessoal

Nome completo
Domingos Manuel Pinto Henrique

Nomes de citação

  • Henrique, Domingos

Identificadores de autor

Ciência ID
C111-5D28-EC65
ORCID iD
0000-0001-8869-1894
Google Scholar ID
https://scholar.google.com/citations?user=GoogleScholarID=en&authuser=1&user=K8mZSYQAAAAJ

Telefones

Telemóvel
  • 969413059 (Pessoal)

Moradas

  • Faculdade de Medicina da Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028, Lisboa, Lisboa, Portugal (Profissional)

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia do Desenvolvimento

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português (Idioma materno)
Francês Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Espanhol; Castelhano Utilizador independente (B2) Utilizador independente (B2) Utilizador independente (B1) Utilizador independente (B2) Utilizador proficiente (C1)
Formação
Grau Classificação
1991
Concluído
 Ciências Farmacêuticas (Licenciatura)
Especialização em Bioquímica
Universidade de Lisboa Faculdade de Farmácia, Portugal
1985
Concluído
 Ciências Farmacêuticas (Mestrado integrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2004 - Atual Investigador Auxiliar (carreira) (Investigação) Universidade de Lisboa Faculdade de Medicina, Portugal
Projetos

Bolsa

Designação Financiadores
2012 - 2016 The V2 domain of the spinal cord as a model to study neuronal fate decisions
PTDC/SAU-BID/121846/2010
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2012 - 2016 The V2 domain of the spinal cord as a model to study neuronal fate decisions
PTDC/SAU-BID/121846/2010
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
2010/03/01 - 2013/08/31 The dialetics of "Stemness": from biology to mathematics
PTDC/SAU-OBD/100664/2008
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007 - 2011 Stem cell based therapy for inner ear hair cell regeneration
PTDC/SAU-NEU/71310/2006
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2000/04/01 - 2004/06/30 THE ROLE OF NOTCH SIGNALLING IN GENERATING NEURONAL DIVERSITY IN THE VERTEBRATE NEURAL RETINA
POCTI/NSE/34622/2000
Investigador responsável
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
1997/06/01 - 1997/09/30 MOLECULAR MECHANISMS REGULATING VERTEBRATE NEURAL DEVELOPMENT: IMPLICATIONS FOR PATHOGENESIS AND THERAPY OF HUMAN NEUROLOGICAL DISEASES
PRAXIS XXI/BPD/14678/97
 Fundação para a Ciência e a Tecnologia
Concluído

Projeto

Designação Financiadores
2019/01/01 - 2019/12/31 Instituto de Medicina Molecular
UID/BIM/50005/2019
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2013/04/08 - 2016/10/07 Animal models of human disease: refinement of strategies and implementation of new technologies
RECI/BIM-MEC/0161/2012
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010/03/01 - 2013/08/31 The dialetics of "Stemness": from biology to mathematics
PTDC/SAU-OBD/100664/2008
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

Massachusetts Institute of Technology, Estados Unidos
Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2013/02/17 Strategic Project - LA 5 - 2011-2012
PEst-OE/SAU/LA0005/2011
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007/09/01 - 2010/12/31 Notch signaling and regulatory mechanisms during mammalian neurogenesis
PTDC/SAU-OBD/75106/2006
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2007/08/27 - 2010/12/31 NEURAL TALK - Scaffold-driven stem-cell regenerative therapy for the spinal cord injury. Biomimeting neurogenesis in the CNS.
PTDC/SAU-BEB/65328/2006
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007/07/01 - 2010/12/31 Uncovering the potential neurodevelopmental deficits in common neonatal conditions such as hyperbilirubinemia and inflammation
PTDC/SAU-NEU/64385/2006
Instituto Politécnico de Coimbra Centro de Estudos de Recursos Naturais Ambiente e Sociedade, Portugal

University of Minnesota Twin Cities Department of Neuroscience, Estados Unidos
Fundação para a Ciência e a Tecnologia
Concluído
2005/09/15 - 2008/06/30 Acute and long-term injury of bilirubin to nerve cells - Looking for sensors, susceptibilities and modulators
POCI/SAU-MMO/55955/2004
Instituto Politécnico de Coimbra Centro de Estudos de Recursos Naturais Ambiente e Sociedade, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em revista
  1. Isabel Alcobia; CARVALHO, Margarida; Henrique, Domingos; Neves, Hélia. Autor correspondente: Neves, Hélia. "Thymus formation in uncharted embryonic territories". BioRxiv (2022): https://doi.org/10.1101/2022.03.09.483697.
    Acesso aberto • No prelo • https://doi.org/10.1101/2022.03.09.483697
  2. Henrique, Domingos; Schweisguth, François. "Mechanisms of Notch signaling: a simple logic deployed in time and space". Development 146 3 (2019): http://dx.doi.org/10.1242/dev.172148.
    10.1242/dev.172148
  3. Henrique, Domingos. "Notch signaling in the epididymal epithelium regulates sperm motility and is transferred at a distance within epididymosomes.". Andrology (2016): http://europepmc.org/abstract/med/26825631.
    10.1111/andr.12144
  4. Henrique, Domingos. "Dissecting Transcriptional Heterogeneity in Pluripotency: Single Cell Analysis of Mouse Embryonic Stem Cells.". Methods in molecular biology (Clifton, N.J.) (2016): http://europepmc.org/abstract/med/27106496.
    10.1007/7651_2016_356
  5. Pezzarossa A; Guedes AM; Henrique D; Abranches E. "Imaging Pluripotency: Time-Lapse Analysis of Mouse Embryonic Stem Cells.". Methods Mol Biol. (2016): http://europepmc.org/abstract/med/26162772.
    10.1007/7651_2015_255
  6. Costa A; Henrique D. "Transcriptome profiling of induced hair cells (iHCs) generated by combined expression of Gfi1, Pou4f3 and Atoh1 during embryonic stem cell differentiation.". (2015): http://europepmc.org/abstract/med/26697340.
    10.1016/j.gdata.2015.08.017
  7. Fernandes TG; Duarte ST; Ghazvini M; Gaspar C; Santos DC; Porteira AR; Rodrigues GM; et al. "Neural commitment of human pluripotent stem cells under defined conditions recapitulates neural development and generates patient-specific neural cells.". (2015): http://europepmc.org/abstract/med/26123315.
    10.1002/biot.201400751
  8. Henrique D; Abranches E; Verrier L; Storey KG. "Neuromesodermal progenitors and the making of the spinal cord.". Development 142 17 (2015): 2864-2875. http://europepmc.org/abstract/med/26329597.
    Acesso aberto • Publicado • 10.1242/dev.119768
  9. Preuße K; Tveriakhina L; Schuster-Gossler K; Gaspar C; Rosa AI; Henrique D; Gossler A; Stauber M. "Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo.". (2015): http://europepmc.org/abstract/med/26114479.
    10.1371/journal.pgen.1005328
  10. Costa A; Sanchez-Guardado L; Juniat S; Gale JE; Daudet N; Henrique D. "Generation of sensory hair cells by genetic programming with a combination of transcription factors.". (2015): http://europepmc.org/abstract/med/26015538.
    10.1242/dev.119149
  11. Nair G; Abranches E; Guedes AM; Henrique D; Raj A. "Heterogeneous lineage marker expression in naive embryonic stem cells is mostly due to spontaneous differentiation.". (2015): http://europepmc.org/abstract/med/26292941.
    10.1038/srep13339
  12. Abranches, Elsa; Guedes, Ana M. V.; Moravec, Martin; Maamar, Hedia; Svoboda, Petr; Raj, Arjun; Henrique, Domingos. "Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency". Development (Cambridge, England) 141 14 (2014): 2770-9. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:25005472&KeyUID=MEDLINE:25005472.
    10.1242/dev.108910
  13. Abranches, E.; Bekman, E.; Henrique, D.. "Generation and Characterization of a Novel Mouse Embryonic Stem Cell Line with a Dynamic Reporter of Nanog Expression". PLoS ONE 8 3 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84875117561&partnerID=MN8TOARS.
    10.1371/journal.pone.0059928
  14. Sanchez-Ripoll, Y.; Bone, H.K.; Owen, T.; Guedes, A.M.V.; Abranches, E.; Kumpfmueller, B.; Spriggs, R.V.; Henrique, D.; Welham, M.J.. "Glycogen Synthase Kinase-3 Inhibition Enhances Translation of Pluripotency-Associated Transcription Factors to Contribute to Maintenance of Mouse Embryonic Stem Cell Self-Renewal". PLoS ONE 8 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84875920551&partnerID=MN8TOARS.
    10.1371/journal.pone.0060148
  15. Vilas-Boas, F.; Fior, R.; Swedlow, J.R.; Storey, K.G.; Henrique, D.. "A novel reporter of notch signalling indicates regulated and random notch activation during vertebrate neurogenesis". BMC Biology 9 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80052185692&partnerID=MN8TOARS.
    10.1186/1741-7007-9-58
  16. Vilas-Boas, F.; Henrique, D.. "HES6-1 and HES6-2 function through different mechanisms during neuronal differentiation". PLoS ONE 5 12 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-78649950965&partnerID=MN8TOARS.
    10.1371/journal.pone.0015459
  17. Henrique, D.; Bally-Cuif, L.. "A cross-disciplinary approach to understanding neural stem cells in development and disease". Development 137 12 (2010): 1933-1938. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953040859&partnerID=MN8TOARS.
    10.1242/dev.052621
  18. Ramos, C.; Rocha, S.; Gaspar, C.; Henrique, D.. "Two notch ligands, Dll1 and Jag1, are differently restricted in their range of action to control neurogenesis in the mammalian spinal cord". PLoS ONE 5 11 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-78649673809&partnerID=MN8TOARS.
    10.1371/journal.pone.0015515
  19. Schulz, H.; Kolde, R.; Adler, P.; Aksoy, I.; Anastassiadis, K.; Bader, M.; Billon, N.; et al. "The FunGenES database: A genomics resource for mouse embryonic stem cell differentiation". PLoS ONE 4 9 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-70249116787&partnerID=MN8TOARS.
    10.1371/journal.pone.0006804
  20. Fior, R.; Henrique, D.. ""Notch-Off": A perspective on the termination of Notch signalling". International Journal of Developmental Biology 53 8-10 (2009): 1379-1384. http://www.scopus.com/inward/record.url?eid=2-s2.0-73949116951&partnerID=MN8TOARS.
    10.1387/ijdb.072309rf
  21. Abranches, E.; Silva, M.; Pradier, L.; Schulz, H.; Hummel, O.; Henrique, D.; Bekman, E.. "Neural differentiation of embryonic stem cells in vitro: A road map to neurogenesis in the embryo". PLoS ONE 4 7 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-67651243800&partnerID=MN8TOARS.
    10.1371/journal.pone.0006286
  22. Fernandes, A.; Falcão, A.S.; Abranches, E.; Bekman, E.; Henrique, D.; Lanier, L.M.; Brites, D.. "Bilirubin as a determinant for altered neurogenesis, neuritogenesis, and synaptogenesis". Developmental Neurobiology 69 9 (2009): 568-582. http://www.scopus.com/inward/record.url?eid=2-s2.0-67749127695&partnerID=MN8TOARS.
    10.1002/dneu.20727
  23. Rocha, S.F.; Lopes, S.S.; Gossler, A.; Henrique, D.. "Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity". Developmental Biology 328 1 (2009): 54-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-61349199483&partnerID=MN8TOARS.
    10.1016/j.ydbio.2009.01.011
  24. Benedito, R.; Trindade, A.; Hirashima, M.; Henrique, D.; Da Costa, L.L.; Rossant, J.; Gill, P.S.; Duarte, A.. "Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli". BMC Developmental Biology 8 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-59649084735&partnerID=MN8TOARS.
    10.1186/1471-213X-8-117
  25. Diogo, M.M.; Henrique, D.; Cabral, J.M.S.. "Optimization and integration of expansion and neural commitment of mouse embryonic stem cells". Biotechnology and Applied Biochemistry 49 2 (2008): 105-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-38749092143&partnerID=MN8TOARS.
    10.1042/BA20070011
  26. Fernandes, A.M.; Fernandes, T.G.; Diogo, M.M.; da Silva, C.L.; Henrique, D.; Cabral, J.M.S.. "Mouse embryonic stem cell expansion in a microcarrier-based stirred culture system". Journal of Biotechnology 132 2 (2007): 227-236. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348996645&partnerID=MN8TOARS.
    10.1016/j.jbiotec.2007.05.031
  27. Abranches, E.; Bekman, E.; Henrique, D.; Cabral, J.M.S.. "Expansion of mouse embryonic stem cells on microcarriers". Biotechnology and Bioengineering 96 6 (2007): 1211-1221. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247101508&partnerID=MN8TOARS.
    10.1002/bit.21191
  28. Afonso, C.; Henrique, D.. "PAR3 acts as a molecular organizer to define the apical domain of chick neuroepithelial cells". Journal of Cell Science 119 20 (2006): 4293-4304. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751165897&partnerID=MN8TOARS.
    10.1242/jcs.03170
  29. Roszko, I.; Afonso, C.; Henrique, D.; Mathis, L.. "Key role played by RhoA in the balance between planar and apico-basal cell divisions in the chick neuroepithelium". Developmental Biology 298 1 (2006): 212-224. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748760345&partnerID=MN8TOARS.
    10.1016/j.ydbio.2006.06.031
  30. Fior, R.; Henrique, D.. "A novel hes5/hes6 circuitry of negative regulation controls Notch activity during neurogenesis". Developmental Biology 281 2 (2005): 318-333. http://www.scopus.com/inward/record.url?eid=2-s2.0-19344373750&partnerID=MN8TOARS.
    10.1016/j.ydbio.2005.03.017
  31. Alsina, B.; Abelló, G.; Ulloa, E.; Henrique, D.; Pujades, C.; Giraldez, F.. "FGF signaling is required for determination of otic neuroblasts in the chick embryo". Developmental Biology 267 1 (2004): 119-134. http://www.scopus.com/inward/record.url?eid=2-s2.0-1242340461&partnerID=MN8TOARS.
    10.1016/j.ydbio.2003.11.012
  32. Duarte, A.; Hirashima, M.; Benedito, R.; Trindade, A.; Diniz, P.; Bekman, E.; Costa, L.; Henrique, D.; Rossant, J.. "Dosage-sensitive requirement for mouse Dll4 in artery development". Genes and Development 18 20 (2004): 2474-2478. http://www.scopus.com/inward/record.url?eid=2-s2.0-5444261424&partnerID=MN8TOARS.
    10.1101/gad.1239004
  33. Henrique, D.; Schweisguth, F.. "Cell polarity: The ups and downs of the Par6/aPKC complex". Current Opinion in Genetics and Development 13 4 (2003): 341-350. http://www.scopus.com/inward/record.url?eid=2-s2.0-0042346345&partnerID=MN8TOARS.
    10.1016/S0959-437X(03)00077-7
  34. Bekman, E.; Henrique, D.. "Erratum: Embryonic expression of three mouse genes with homology to the Drosophila melanogaster prickle gene (Gene Expression Patterns (2002) vol. 2 (73-77))". Gene Expression Patterns 3 4 (2003): http://www.scopus.com/inward/record.url?eid=2-s2.0-0043199557&partnerID=MN8TOARS.
    10.1016/S0925-4773(02)00379-9
  35. Kawakami, Y.; Rodríguez-León, J.; Koth, C.M.; Büscher, D.; Itoh, T.; Raya, Á.; Ng, J.K.; et al. "MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb". Nature Cell Biology 5 6 (2003): 513-519. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038713378&partnerID=MN8TOARS.
    10.1038/ncb989
  36. ABRANCHES, E; BEKMAN, E; HENRIQUE, D; CABRAL, JMS; Albranches, E.; Bekman, E.; Henrique, D.; Cabral, J.M.S.. "Expansion and neural differentiation of embryonic stem cells in adherent and suspension cultures". Biotechnology Letters 25 9 (2003): 725-730. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000182445200012&KeyUID=WOS:000182445200012.
    10.1023/A:1023462832608
  37. Abranches, E.; Bekman, E.; Henrique, D.; Cabral, J.M.S.. "Erratum: Expansion and neural differentiation of embryonic stem cells in adherent and suspension cultures (Biotechnology letters (2003) 25 (725-730))". Biotechnology Letters 25 12 (2003): http://www.scopus.com/inward/record.url?eid=2-s2.0-0037742397&partnerID=MN8TOARS.
  38. BEKMAN, E; HENRIQUE, D. "Embryonic expression of three mouse genes with homology to the Drosophila melanogaster prickle gene". Mechanisms of Development 119 (2002): S77-S81. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000202950500011&KeyUID=WOS:000202950500011.
  39. Jaleco, A.C.; Neves, H.; Hooijberg, E.; Gameiro, P.; Clode, N.; Haury, M.; Henrique, D.; Parreira, L.. "Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation". Journal of Experimental Medicine 194 7 (2001): 991-1001. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035476891&partnerID=MN8TOARS.
    10.1084/jem.194.7.991
  40. PASINI, A; HENRIQUE, D; WILKINSON, DG; Pasini, A.; Henrique, D.; Wilkinson, D.G.. "The zebrafish Hairy/Enhancer-of-split-related gene her6 is segmentally expressed during the early development of hindbrain and somites". Mechanisms of Development 100 2 (2001): 317-321. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000166837600016&KeyUID=WOS:000166837600016.
    10.1016/S0925-4773(00)00538-4
  41. HIRSINGER, E; MALAPERT, P; DUBRULLE, J; DELFINI, MC; DUPREZ, D; HENRIQUE, D; ISH-HOROWICZ, D; et al. "Notch signalling acts in postmitotic avian myogenic cells to control MyoD activation". Development 128 1 (2001): 107-116. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000166452100011&KeyUID=WOS:000166452100011.
  42. CAMPOS, LS; DUARTE, AJ; BRANCO, T; HENRIQUE, D; Campos, L.S.; Duarte, A.J.; Branco, T.; Henrique, D.. "mDll1 and mDll3 expression in the developing mouse brain: Role in the establishment of the early cortex". Journal of Neuroscience Research 64 6 (2001): 590-598. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000169032800005&KeyUID=WOS:000169032800005.
    10.1002/jnr.1111
  43. Jouve, C.; Palmeirim, I.; Henrique, D.; Beckers, J.; Gossler, A.; Ish-Horowicz, D.; Pourquié, O.; et al. "Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesoderm". Development 127 7 (2000): 1421-1429. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034098483&partnerID=MN8TOARS.
  44. PISSARRA, L; HENRIQUE, D; DUARTE, A; Pissarra, L.; Henrique, D.; Duarte, A.. "Expression of hes6, a new member of the Hairy/Enhancer-of-split family, in mouse development". Mechanisms of Development 95 1-2 (2000): 275-278. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000088607200032&KeyUID=WOS:000088607200032.
    10.1016/S0925-4773(00)00348-8
  45. Gray, G.E.; Mann, R.S.; Mitsiadis, E.; Henrique, D.; Carcangiu, M.-L.; Banks, A.; Leiman, J.; et al. "Human ligands of the Notch receptor". American Journal of Pathology 154 3 (1999): 785-794. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032996755&partnerID=MN8TOARS.
  46. PALMEIRIM, I; DUBRULLE, J; HENRIQUE, D; ISH-HOROWICZ, D; POURQUIE, O; Palmeirim, I.; Dubrulle, J.; et al. "Uncoupling segmentation and somitogenesis in the chick presomitic mesoderm". Developmental Genetics 23 1 (1998): 77-85. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000075132000008&KeyUID=WOS:000075132000008.
    10.1002/(SICI)1520-6408(1998)23:1<77::AID-DVG8>3.0.CO;2-3
  47. HADDON, C; SMITHERS, L; SCHNEIDER-MAUNOURY, S; COCHE, T; HENRIQUE, D; LEWIS, J; Haddon, C.; et al. "Multiple delta genes and lateral inhibition in zebrafish primary neurogenesis". Development 125 3 (1998): 359-370. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000072350300003&KeyUID=WOS:000072350300003.
  48. Adam, J.; Myat, A.; Le Roux, I.; Eddison, M.; Henrique, D.; Ish-Horowicz, D.; Lewis, J.; et al. "Cell fate choices and the expression of Notch, Delta and Serrate homologues in the chick inner ear: Parallels with Drosophila sense-organ development". Development 125 23 (1998): 4645-4654. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032427792&partnerID=MN8TOARS.
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Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021 - 2021 Toward Chromosome 6 Replacement in hPSCs by Editing Nucleases and Microcell Mediated Chromosome Transfer (MMCT)
Orientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019 - 2019 Studies on the proneural factor Ascl1 in the context of mitotic bookmarking
Coorientador
 Neurociências (Mestrado)
Universidade de Lisboa Faculdade de Medicina, Portugal
2015 - 2015 Analysis of the Gene Regulatory Network underlying pluripotenciality in mouse Embryonic Stem cells
Orientador
 Bioengenharia (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2010 - 2014 From Embryonic Stem Cells to Sensory Hair Cells: a Programming Approach
Orientador
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2010 - 2010 Investigating Cell Fate Decisions of the Intestinal Stem Cell
Coorientador
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa, Portugal
2005 - 2009 The role of multiple DSL ligands Dll1, Dll4 and Jag1 - in vertebrate neurogenesis
Orientador
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2003 - 2007 The role of HES genes in the controlled production of neurons
Orientador
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa Faculdade de Medicina, Portugal
2006 - 2006 Ex Vivo Expansion and Neural Differentiation of Mouse Embryonic Stem Cells
Coorientador
 Biotecnologia (Doutoramento)
2002 - 2006 Cell polarity in the embryonic chick neuroepithelium: role of the PAR polarity complex
Orientador
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa, Portugal
2005 - 2005 Functional Analysis of the Notch Signaling Cascade in Neural Progenitors
Orientador
 Ciências Biomédicas (Doutoramento)
Universidade de Lisboa, Portugal
Distinções

Prémio

1997 Gulbenkian Prize of Science
Fundação Calouste Gulbenkian, Portugal