| Artigo em revista |
- Soraia Silva; Carla Fonseca; Joana Bicker; Amílcar Falcão; Ana Fortuna. "Intranasal administration of sertraline ensures sustained
brain delivery and antidepressant effect in a mouse model of depression". European Journal of Pharmaceutics and Biopharmaceutics
(2024): https://doi.org/10.1016/j.ejpb.2023.12.002.
10.1016/j.ejpb.2023.12.002
- Flores-Felix, Jose David; Goncalves, Ana Carolina; Meirinho, Sara; Nunes, Ana Raquel; Alves, Gilberto; Garcia-Viguera, Cristina;
Moreno, Diego A.; Silva, Luis R.. "Differential response of blueberry to the application of bacterial inoculants to improve
yield, organoleptic qualities and concentration of bioactive compounds". Microbiological Research (2024): https://publons.com/wos-op/publon/64406946/.
10.1016/J.MICRES.2023.127544
- Catarina Candeias; Jorge Gama; Márcio Rodrigues; Amílcar Falcão; Gilberto Alves. "Patients’ Characterization, Pattern of Medication
Use, and Factors Associated with Polypharmacy: A Cross-Sectional Study Focused on Eight Units of the Portuguese National Network
for Long-Term Integrated Care". Healthcare (2023): https://doi.org/10.3390/healthcare12010057.
10.3390/healthcare12010057
- Ana C. Gonçalves; Amílcar Falcão; Gilberto Alves; Luís R. Silva; José D. Flores-Félix. "Diversity of Culture Microorganisms
from Portuguese Sweet Cherries". Life (2023): https://doi.org/10.3390/life13122323.
10.3390/life13122323
- Rui Silva; Helena Colom; Joana Bicker; Anabela Almeida; Ana Silva; Francisco Sales; Isabel Santana; Amílcar Falcão; Ana Fortuna.
"Population Pharmacokinetic Analysis of Perampanel in Portuguese Patients Diagnosed with Refractory Epilepsy". Pharmaceutics
(2023): https://doi.org/10.3390/pharmaceutics15061704.
10.3390/pharmaceutics15061704
- Ivanna Hrynchak; Diana Cocioaba; Alexandra I. Fonseca; Radu Leonte; Sérgio J. C. do Carmo; Roxana Cornoiu; Amílcar Falcão;
Dana Niculae; Antero J. Abrunhosa. "Antibody and Nanobody Radiolabeling with Copper-64: Solid vs. Liquid Target Approach".
Molecules (2023): https://doi.org/10.3390/molecules28124670.
10.3390/molecules28124670
- Sara Meirinho; Márcio Rodrigues; Adriana O. Santos; Amílcar Falcão; Gilberto Alves. "Intranasal Microemulsion as an Innovative
and Promising Alternative to the Oral Route in Improving Stiripentol Brain Targeting". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15061641.
10.3390/pharmaceutics15061641
- Ana C. Gonçalves; Ana R. Nunes; Sara Meirinho; Miguel Ayuso-Calles; Rocío Roca-Couso; Raúl Rivas; Amílcar Falcão; et al. "Exploring
the Antioxidant, Antidiabetic, and Antimicrobial Capacity of Phenolics from Blueberries and Sweet Cherries". Applied Sciences
(2023): https://doi.org/10.3390/app13106348.
10.3390/app13106348
- Maria Aquino; Maria Tinoco; Joana Bicker; Amílcar Falcão; Marília Rocha; Ana Fortuna. "Therapeutic Drug Monitoring of Amikacin
in Neutropenic Oncology Patients". Antibiotics (2023): https://doi.org/10.3390/antibiotics12020373.
10.3390/antibiotics12020373
- Meirinho, Sara; Rodrigues, Marcio; Santos, Adriana O.; Falcao, Amilcar; Alves, Gilberto. "Nose-to-brain delivery of perampanel
formulated in a self-microemulsifying drug delivery system improves anticonvulsant and anxiolytic activity in mice". International
Journal of Pharmaceutics (2023): https://publons.com/wos-op/publon/62149279/.
10.1016/J.IJPHARM.2023.123145
- Matias, Mariana; Santos, Adriana O. O.; Silvestre, Samuel; Alves, Gilberto. "Fighting Epilepsy with Nanomedicines-Is This
the Right Weapon?". Pharmaceutics (2023): https://publons.com/wos-op/publon/56668178/.
10.3390/PHARMACEUTICS15020306
- Nunes, Ana R. R.; Costa, Elisabete C. C.; Alves, Gilberto; Silva, Luis R.. "Nanoformulations for the Delivery of Dietary Anthocyanins
for the Prevention and Treatment of Diabetes Mellitus and Its Complications". Pharmaceuticals (2023): https://publons.com/wos-op/publon/57401784/.
10.3390/PH16050736
- Brito, Vanessa; Marques, Mariana; Esteves, Marta; Serra-Almeida, Catarina; Alves, Gilberto; Almeida, Paulo; Bernardino, Liliana;
Silvestre, Samuel. "Synthesis, In Vitro Biological Evaluation of Antiproliferative and Neuroprotective Effects and In Silico
Studies of Novel 16E-Arylidene-5 alpha,6 alpha-epoxyepiandrosterone Derivatives". Biomedicines (2023): https://publons.com/wos-op/publon/60105202/.
10.3390/BIOMEDICINES11030812
- Pires, Patricia C.; Fernandes, Mariana; Nina, Francisca; Gama, Francisco; Gomes, Maria F.; Rodrigues, Lina E.; Meirinho, Sara;
et al. "Innovative Aqueous Nanoemulsion Prepared by Phase Inversion Emulsification with Exceptional Homogeneity". Pharmaceutics
(2023): https://publons.com/wos-op/publon/60961448/.
10.3390/PHARMACEUTICS15071878
- Ana R. Nunes; José D. Flores-Félix; Ana C. Gonçalves; Amílcar Falcão; Gilberto Alves; Luís R. Silva. "Anti-Inflammatory and
Antimicrobial Activities of Portuguese Prunus avium L. (Sweet Cherry) By-Products Extracts". Nutrients (2022): https://doi.org/10.3390/nu14214576.
10.3390/nu14214576
- Ana C. Gonçalves; Amílcar Falcão; Gilberto Alves; João A. Lopes; Luís R. Silva. "Employ of Anthocyanins in Nanocarriers for
Nano Delivery: In Vitro and In Vivo Experimental Approaches for Chronic Diseases". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14112272.
10.3390/pharmaceutics14112272
- Rui Silva; Joana Bicker; Anabela Almeida; Andreia Carona; Ana Silva; Francisco Sales; Isabel Santana; Amílcar Falcão; Ana
Fortuna. "Clinical Application of Pharmacokinetics to Appraise Adherence to Levetiracetam in Portuguese Epileptic Patients".
Biomedicines (2022): https://doi.org/10.3390/biomedicines10092127.
10.3390/biomedicines10092127
- Sara Meirinho; Márcio Rodrigues; Adriana O. Santos; Amílcar Falcão; Gilberto Alves. "Self-Emulsifying Drug Delivery Systems:
An Alternative Approach to Improve Brain Bioavailability of Poorly Water-Soluble Drugs through Intranasal Administration".
Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14071487.
10.3390/pharmaceutics14071487
- Ana C. Gonçalves; Dário Gaspar; José David Flores-Félix; Amílcar Falcão; Gilberto Alves; Luís R. Silva. "Effects of Functional
Phenolics Dietary Supplementation on Athletes’ Performance and Recovery: A Review". International Journal of Molecular
Sciences (2022): https://doi.org/10.3390/ijms23094652.
10.3390/ijms23094652
- Catarina Canário; Mariana Matias; Vanessa Brito; Patrícia Pires; Adriana O. Santos; Amílcar Falcão; Samuel Silvestre; Gilberto
Alves. "C-Ring Oxidized Estrone Acetate Derivatives: Assessment of Antiproliferative Activities and Docking Studies". Applied
Sciences 12 7 (2022): 3579-3579. https://doi.org/10.3390/app12073579.
10.3390/app12073579
- Ana R. Nunes; Ana C. Gonçalves; Edgar Pinto; Filipa Amaro; José D. Flores-Félix; Agostinho Almeida; Paula Guedes de Pinho;
et al. "Mineral Content and Volatile Profiling of Prunus avium L. (Sweet Cherry) By-Products from Fundão Region (Portugal)".
Foods 11 5 (2022): 751-751. https://doi.org/10.3390/foods11050751.
10.3390/foods11050751
- Gonçalves, Ana C.; Costa, AR; Jose David Flores Felix; Amílcar Falcão; Gilberto Alves; Luís Rodrigues da Silva. "Anti-Inflammatory
and Antiproliferative Properties of Sweet Cherry Phenolic-Rich Extracts". Molecules (2022): https://www.mdpi.com/1420-3049/27/1/268.
10.3390/molecules27010268
- Goncalves, Ana. C; Falcao, Amilcar; Alves, Gilberto; Lopes, Joao A.; Silva, Luis R.. "Employ of Anthocyanins in Nanocarriers
for Nano Delivery: In Vitro and In Vivo Experimental Approaches for Chronic Diseases". Preprints.org (2022): https://publons.com/wos-op/publon/55384669/.
10.20944/PREPRINTS202210.0142
- Goncalves, Ana C.; Sanchez-Juanes, Fernando; Meirinho, Sara; Silva, Luis R.; Alves, Gilberto; Flores-Felix, Jose David. "Insight
into the Taxonomic and Functional Diversity of Bacterial Communities Inhabiting Blueberries in Portugal". Microorganisms
(2022): https://publons.com/wos-op/publon/54782519/.
10.3390/MICROORGANISMS10112193
- Canario, Catarina; Matias, Mariana; de Brito, Vanessa; Cruz-Vicente, Pedro; Soeiro, Pedro; Santos, Adriana O.; Falcao, Amilcar;
Silvestre, Samuel; Alves, Gilberto. "10 beta-Hydroxyestra-1,4-diene-3,17-dione as potential antiproliferative agent: in vitro
biological evaluation and in silico studies". Natural Product Research (2022): https://publons.com/wos-op/publon/52576558/.
10.1080/14786419.2022.2039136
- Meirinho, Sara; Rodrigues, Marcio; Ferreira, Catarina L.; Oliveira, Rui Caetano; Fortuna, Ana; Santos, Adriana O.; Falcao,
Amilcar; Alves, Gilberto. "Intranasal delivery of lipid-based nanosystems as a promising approach for brain targeting of the
new-generation antiepileptic drug perampanel". International Journal of Pharmaceutics (2022): https://publons.com/wos-op/publon/53241174/.
10.1016/J.IJPHARM.2022.121853
- Goncalves, Ana C.; Nunes, Ana R.; Flores-Felix, Jose D.; Alves, Gilberto; Silva, Luis R.. "Cherries and Blueberries-Based
Beverages: Functional Foods with Antidiabetic and Immune Booster Properties". Molecules (2022): https://publons.com/wos-op/publon/52399331/.
10.3390/MOLECULES27103294
- Pires, Patricia C.; Rodrigues, Marcio; Alves, Gilberto; Santos, Adriana O.. "Strategies to Improve Drug Strength in Nasal
Preparations for Brain Delivery of Low Aqueous Solubility Drugs". Pharmaceutics (2022): https://publons.com/wos-op/publon/51553107/.
10.3390/PHARMACEUTICS14030588
- Meirinho, Sara; Rodrigues, Marcio; Fortuna, Ana; Falcao, Amilcar; Alves, Gilberto. "Study of the metabolic stability profiles
of perampanel, rufinamide and stiripentol and prediction of drug interactions using HepaRG cells as an in vitro
human model". Toxicology in Vitro (2022): https://publons.com/wos-op/publon/53241173/.
10.1016/J.TIV.2022.105389
- Goncalves, Ana C.; Campos, Goncalo; Pinto, Edgar; Oliveira, Ana Sofia; Almeida, Agostinho; de Pinho, Paula Guedes; Alves,
Gilberto; Silva, Luis R.. "Essential and non-essential elements, and volatile organic compounds for the discrimination of
twenty-three sweet cherry cultivars from Fundao, Portugal". Food Chemistry (2022): https://publons.com/wos-op/publon/50902117/.
10.1016/J.FOODCHEM.2021.130503
- Monteiro, Cristina; Silvestre, Samuel; Duarte, Ana Paula; Alves, Gilberto. "Safety of Non-Steroidal Anti-Inflammatory Drugs
in the Elderly: An Analysis of Published Literature and Reports Sent to the Portuguese Pharmacovigilance System". International
Journal of Environmental Research and Public Health (2022): https://publons.com/wos-op/publon/51636981/.
10.3390/IJERPH19063541
- Goncalves, Ana C.; Rodrigues, Marcio; Flores-Felix, Jose David; Campos, Goncalo; Nunes, Ana R.; Ribeiro, Alessandra Braga;
Silva, Luis R.; Alves, Gilberto. "Sweet cherry phenolics revealed to be promising agents in inhibiting P-glycoprotein activity
and increasing cellular viability under oxidative stress conditions: in vitro and in silico study". Journal of Food Science
(2022): https://publons.com/wos-op/publon/50902118/.
10.1111/1750-3841.16001
- Rodrigues, Marcio; Ali, Javed; Alves, Gilberto. "Editorial: Intranasal Delivery of Central Nervous System Active Drugs: Opportunities
and Challenges". Frontiers in Pharmacology (2022): https://publons.com/wos-op/publon/54170811/.
10.3389/FPHAR.2022.927812
- Brito, Vanessa; Santos, Adriana Oliveira; Alves, Gilberto; Almeida, Paulo; Silvestre, Samuel. "Novel 4-Azapregnene Derivatives
as Potential Anticancer Agents: Synthesis, Antiproliferative Activity and Molecular Docking Studies". Molecules (2022):
https://publons.com/wos-op/publon/53864623/.
10.3390/MOLECULES27186126
- Jesus, Fabio; Goncalves, Ana C.; Alves, Gilberto; Silva, Luis R.. "Health Benefits of Prunus avium Plant Parts: An
Unexplored Source Rich in Phenolic Compounds". Food Reviews International (2022): https://publons.com/wos-op/publon/34899857/.
10.1080/87559129.2020.1854781
- Goncalves, Ana C.; Flores-Felix, Jose David; Coutinho, Paula; Alves, Gilberto; Silva, Luis R.. "Zimbro (Juniperus communis
L.) as a Promising Source of Bioactive Compounds and Biomedical Activities: A Review on Recent Trends". International Journal
of Molecular Sciences (2022): https://publons.com/wos-op/publon/51861124/.
10.3390/IJMS23063197
- Nunes, Ana R.; Sanchez-Juanes, Fernando; Goncalves, Ana C.; Alves, Gilberto; Silva, Luis R.; Flores-Felix, Jose David. "Evaluation
of Raw Cheese as a Novel Source of Biofertilizer with a High Level of Biosecurity for Blueberry". Agronomy (2022):
https://publons.com/wos-op/publon/52438621/.
10.3390/AGRONOMY12051150
- Soraia Silva; Joana Bicker; Amílcar Falcão; Ana Fortuna. "Antidepressants and Circadian Rhythm: Exploring Their Bidirectional
Interaction for the Treatment of Depression". Pharmaceutics (2021): https://doi.org/10.3390/pharmaceutics13111975.
10.3390/pharmaceutics13111975
- Ana C. Gonçalves; José D. Flores-Félix; Ana R. Costa; Amílcar Falcão; Gilberto Alves; Luís R. Silva. "Hepatoprotective Effects
of Sweet Cherry Extracts (cv. Saco)". Foods (2021): https://doi.org/10.3390/foods10112623.
10.3390/foods10112623
- Ivanna Hrynchak; Liliana Santos; Amílcar Falcão; Célia M. Gomes; Antero J. Abrunhosa. "Nanobody-Based Theranostic Agents for
HER2-Positive Breast Cancer: Radiolabeling Strategies". International Journal of Molecular Sciences 22 19 (2021): 10745-10745.
https://doi.org/10.3390/ijms221910745.
10.3390/ijms221910745
- Ana R. Nunes; Ana C. Gonçalves; Amílcar Falcão; Gilberto Alves; Luís R. Silva. "Prunus avium L. (Sweet Cherry) By-Products:
A Source of Phenolic Compounds with Antioxidant and Anti-Hyperglycemic Properties—A Review". Applied Sciences 11 18
(2021): 8516-8516. https://doi.org/10.3390/app11188516.
10.3390/app11188516
- Ana R. Nunes; Ana C. Gonçalves; Gilberto Alves; Amílcar Falcão; Cristina Garcia-Viguera; Diego A. Moreno; Luís R. Silva. "Valorisation
of Prunus avium L. By-Products: Phenolic Composition and Effect on Caco-2 Cells Viability". Foods 10 6 (2021): 1185-1185.
https://doi.org/10.3390/foods10061185.
10.3390/foods10061185
- Catarina Canário; Mariana Matias; Vanessa Brito; Adriana O. Santos; Amílcar Falcão; Samuel Silvestre; Gilberto Alves. "New
Estrone Oxime Derivatives: Synthesis, Cytotoxic Evaluation and Docking Studies". Molecules (2021): https://doi.org/10.3390/molecules26092687.
10.3390/molecules26092687
- Silva, Soraia; Bicker, Joana; Fonseca, Carla; Ferreira, Nuno R.; Vitorino, Carla; Alves, Gilberto; Falcao, Amilcar; Fortuna,
Ana. "Encapsulated Escitalopram and Paroxetine Intranasal Co-Administration: In Vitro/In Vivo Evaluation". Frontiers
in Pharmacology (2021): https://publons.com/wos-op/publon/53155798/.
10.3389/FPHAR.2021.751321
- Lahlou, Radhia Aitfella; Bounechada, Mustapha; Mohammedi, Arezki; Silva, Luis R.; Alves, Gilberto. "Dietary use of Rosmarinus
officinalis and Thymus vulgaris as anticoccidial alternatives in poultry". Animal Feed Science and Technology
(2021): https://publons.com/wos-op/publon/36475344/.
10.1016/J.ANIFEEDSCI.2021.114826
- Goncalves, Ana C.; Campos, Goncalo; Alves, Gilberto; Garcia-Viguera, Cristina; Moreno, Diego A.; Silva, Luis R.. "Physical
and phytochemical composition of 23 Portuguese sweet cherries as conditioned by variety (or genotype)". Food Chemistry
(2021): https://publons.com/wos-op/publon/37776173/.
10.1016/J.FOODCHEM.2020.127637
- Monteiro, Cristina; Duarte, Ana Paula; Alves, Gilberto. "Adverse drug reactions in elderly: a five-year review of spontaneous
reports to the Portuguese pharmacovigilance system". Expert Opinion on Drug Safety (2021): https://publons.com/wos-op/publon/31881632/.
10.1080/14740338.2020.1849137
- Candeias, Catarina; Gama, Jorge; Rodrigues, Marcio; Falcao, Amilcar; Alves, Gilberto. "Potentially Inappropriate Medications
and Potential Prescribing Omissions in Elderly Patients Receiving Post-Acute and Long-Term Care: Application of Screening
Tool of Older People's Prescriptions/Screening Tool to Alert to Right Treatment Criteria". Frontiers in Pharmacology
(2021): https://publons.com/wos-op/publon/55384670/.
10.3389/FPHAR.2021.747523
- Goncalves, Ana C.; Nunes, Ana R.; Falcao, Amilcar; Alves, Gilberto; Silva, Luis R.. "Dietary Effects of Anthocyanins in Human
Health: A Comprehensive Review". Pharmaceuticals (2021): https://publons.com/wos-op/publon/45753537/.
10.3390/PH14070690
- Flores-Felix, Jose David; Goncalves, Ana C.; Alves, Gilberto; Silva, Luis R.. "Consumption of Phenolic-Rich Food and Dietary
Supplements as a Key Tool in SARS-CoV-19 Infection". Foods (2021): https://publons.com/wos-op/publon/49132843/.
10.3390/FOODS10092084
- Goncalves, Ana C.; Lahlou, Radhia Aitfella; Alves, Gilberto; Garcia-Viguera, Cristina; Moreno, Diego A.; Silva, Luis R.. "Potential
Activity of Abrantes Pollen Extract: Biochemical and Cellular Model Studies". Foods (2021): https://publons.com/wos-op/publon/49938752/.
10.3390/FOODS10112804
- Eusebio, Dalinda; Neves, Ana R.; Costa, Diana; Biswas, Swati; Alves, Gilberto; Cui, Zhengrong; Sousa, Angela. "Methods to
improve the immunogenicity of plasmid DNA vaccines". Drug Discovery Today (2021): https://publons.com/wos-op/publon/48174093/.
10.1016/J.DRUDIS.2021.06.008
- Meirinho, Sara; Rodrigues, Marcio; Fortuna, Ana; Falcao, Amilcar; Alves, Gilberto. "Liquid chromatographic methods for determination
of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review". Journal
of Pharmaceutical Analysis (2021): https://publons.com/wos-op/publon/53241181/.
10.1016/J.JPHA.2020.11.005
- Monteiro, Cristina; Silvestre, Samuel; Duarte, Ana Paula; Alves, Gilberto. "Assessment of suspected adverse drug reactions
in elderly patients with diabetes mellitus based on a Portuguese spontaneous reporting database: analysis of reporting from
2008 to 2018". Expert Opinion on Drug Safety (2021): https://publons.com/wos-op/publon/38801702/.
10.1080/14740338.2021.1928072
- Falch, Catharine; Alves, Gilberto. "Pharmacists' Role in Older Adults' Medication Regimen Complexity: A Systematic Review".
International Journal of Environmental Research and Public Health (2021): https://publons.com/wos-op/publon/55384671/.
10.3390/IJERPH18168824
- Brito, Vanessa; Alves, Gilberto; Almeida, Paulo; Silvestre, Samuel. "Highlights on Steroidal Arylidene Derivatives as a Source
of Pharmacologically Active Compounds: A Review". Molecules (2021): https://publons.com/wos-op/publon/43110775/.
10.3390/MOLECULES26072032
- Pires, Patricia C.; Fazendeiro, Ana C.; Rodrigues, Marcio; Alves, Gilberto; Santos, Adriana O.. "Nose-to-brain delivery of
phenytoin and its hydrophilic prodrug fosphenytoin combined in a microemulsion-formulation development and in vivo pharmacokinetics".
European Journal of Pharmaceutical Sciences (2021): https://publons.com/wos-op/publon/42322304/.
10.1016/J.EJPS.2021.105918
- Goncalves, Joana; Silva, Soraia; Gouveia, Filipa; Bicker, Joana; Falcao, Amilcar; Alves, Gilberto; Fortuna, Ana. "A combo-strategy
to improve brain delivery of antiepileptic drugs: Focus on BCRP and intranasal administration". International Journal of
Pharmaceutics (2021): https://publons.com/wos-op/publon/37112702/.
10.1016/J.IJPHARM.2020.120161
- Gonsalves, Joana; Alves, Gilberto; Fonseca, Carla; Carona, Andreia; Bicker, Joana; Falcao, Amilcar; Fortuna, Ana. "Is intranasal
administration an opportunity for direct brain delivery of lacosamide?". European Journal of Pharmaceutical Sciences
(2021): https://publons.com/wos-op/publon/36792415/.
10.1016/J.EJPS.2020.105632
- Pires, Patricia C.; Santos, Liliana T.; Rodrigues, Marcio; Alves, Gilberto; Santos, Adriana O.. "Intranasal fosphenytoin:
The promise of phosphate esters in nose-to-brain delivery of poorly soluble drugs". International Journal of Pharmaceutics
(2021): https://publons.com/wos-op/publon/36852580/.
10.1016/J.IJPHARM.2020.120040
- Goncalves, Ana C.; Nunes, Ana R.; Alves, Gilberto; Silva, Luis R.. "Serotonin and Melatonin: Plant Sources, Analytical Methods,
and Human Health Benefits". Revista Brasileira de Farmacognosia (2021): https://publons.com/wos-op/publon/45020411/.
10.1007/S43450-021-00141-W
- Carla Fonseca; Joana Bicker; Gilberto Alves; Amílcar Falcão; Ana Fortuna. "Cystic fibrosis: Physiopathology and the latest
pharmacological treatments". Pharmacological Research (2020): 105267-105267. https://doi.org/10.1016/j.phrs.2020.105267.
10.1016/j.phrs.2020.105267
- Rui Silva; Anabela Almeida; Joana Bicker; Joana Gonçalves; Andreia Carona; Ana Silva; Isabel Santana; et al. "Pharmacokinetic
Monitoring of Levetiracetam in Portuguese Refractory Epileptic Patients: Effect of Gender, Weight and Concomitant Therapy".
Pharmaceutics 12 10 (2020): 943-943. https://doi.org/10.3390/pharmaceutics12100943.
10.3390/pharmaceutics12100943
- Sarah Pousinho; Manuel Morgado; Ana I. Plácido; Fátima Roque; Amílcar Falcão; Gilberto Alves. "Clinical pharmacists´ interventions
in the management of type 2 diabetes mellitus: a systematic review". Pharmacy Practice (2020): https://doi.org/10.18549/PharmPract.2020.3.2000.
10.18549/PharmPract.2020.3.2000
- Joana Bicker; Gilberto Alves; Amílcar Falcão; Ana Fortuna. "Timing in drug absorption and disposition: The past, present,
and future of chronopharmacokinetics". British Journal of Pharmacology (2020): https://doi.org/10.1111/bph.15017.
10.1111/bph.15017
- Joana Bicker; Ana Fortuna; Gilberto Alves; Amílcar Falcão. "Nose-to-brain Delivery of Natural Compounds for the Treatment
of Central Nervous System Disorders". Current Pharmaceutical Design 26 (2020): https://doi.org/10.2174/1381612826666200115101544.
10.2174/1381612826666200115101544
- Kirkham, F.; Auvin, S.; Moreira, J.; Gama, H.; Falcão, A.C.; Rocha, J.-F.; Soares-da-Silva, P.. "Efficacy and safety of eslicarbazepine
acetate as adjunctive therapy for refractory focal-onset seizures in children: A double-blind, randomized, placebo-controlled,
parallel-group, multicenter, phase-III clinical trial". Epilepsy and Behavior 105 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85080994312&partnerID=MN8TOARS.
10.1016/j.yebeh.2020.106962
- Calmeiro, J.; Carrascal, M.A.; Tavares, A.R.; Ferreira, D.A.; Gomes, C.; Falcão, A.; Cruz, M.T.; Neves, B.M.. "Dendritic cell
vaccines for cancer immunotherapy: The role of human conventional type 1 dendritic cells". Pharmaceutics 12 2 (2020):
http://www.scopus.com/inward/record.url?eid=2-s2.0-85079682158&partnerID=MN8TOARS.
10.3390/pharmaceutics12020158
- Gouveia, F.; Bicker, J.; Santos, J.; Rocha, M.; Alves, G.; Falcão, A.; Fortuna, A.. "Development, validation and application
of a new HPLC-DAD method for simultaneous quantification of apixaban, dabigatran, edoxaban and rivaroxaban in human plasma".
Journal of Pharmaceutical and Biomedical Analysis 181 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078513077&partnerID=MN8TOARS.
10.1016/j.jpba.2020.113109
- Goncalves, Joana; Silva, Soraia; Vitorino, Carla; Alves, Gilberto; Fortuna, Ana. "HOW DOES THE DEVICE DETERMINE NOSE-TO-BRAIN
DRUG DELIVERY TO MICE?". Journal of Aerosol Medicine and Pulmonary Drug Delivery (2020): https://publons.com/wos-op/publon/53241183/.
- Rodrigues, Marcio; Lopes, Ana Clara; Vaz, Filipa; Filipe, Melanie; Alves, Gilberto; Ribeiro, Maximiano P.; Coutinho, Paula;
Araujo, Andre R. T. S.. "Thymus mastichina: Composition and Biological Properties with a Focus on Antimicrobial Activity".
Pharmaceuticals (2020): https://publons.com/wos-op/publon/35839676/.
10.3390/PH13120479
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of lamotrigine given as a single-dose in Wistar rats". Food and Chemical Toxicology 128 (2019): 61-67. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063732494&partnerID=MN8TOARS.
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to improve antibiotic-prescribing behaviour in primary care: A controlled, interrupted time-series study". Journal of Antimicrobial
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polymer-lipid hybrid nanoparticles". International Journal of Pharmaceutics 554 (2019): 352-365. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056766454&partnerID=MN8TOARS.
10.1016/j.ijpharm.2018.11.028
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in mouse plasma and tissues using HPLC-UV: A tool to support pharmacokinetic studies". Journal of Chromatography B: Analytical
Technologies in the Biomedical and Life Sciences 1124 (2019): 340-348. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068216980&partnerID=MN8TOARS.
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reductions of vancomycin required in neonates with patent ductus arteriosus receiving indomethacin versus ibuprofen". Antimicrobial
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and HPLC-MS methods for the determination of exenatide in biological and biotechnology-based formulation matrices". Journal
of Pharmaceutical Analysis 9 3 (2019): 143-155. http://www.scopus.com/inward/record.url?eid=2-s2.0-85065783299&partnerID=MN8TOARS.
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for Propofol Anesthesia Guided by the Bispectral Index (BIS)". Journal of Clinical Pharmacology (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85076153415&partnerID=MN8TOARS.
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inhibitor with impact on the pharmacokinetics of carbamazepine, oxcarbazepine and phenytoin in rats". Drug and Chemical
Toxicology (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85065181492&partnerID=MN8TOARS.
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A.J.. "First-time oral administration of resveratrol-loaded layer-by-layer nanoparticles to rats-a pharmacokinetics study".
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Treated With Antidepressant Drugs Focused on (Non-)Genetic Factors, Pharmacokinetics, and Clinical Outcomes: GnG-PK/PD-AD
Study". Experimental and Clinical Psychopharmacology (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85065972663&partnerID=MN8TOARS.
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Characterization, and Health Benefits". Studies in Natural Products Chemistry (2019): https://publons.com/wos-op/publon/38384979/.
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- Gonçalo Campos; Ana Fortuna; Amílcar Falcão; Gilberto Alves. "In vitro and in vivo experimental models employed in the discovery
and development of antiepileptic drugs for pharmacoresistant epilepsy". Epilepsy Research 146 (2018): 63-86. https://doi.org/10.1016/j.eplepsyres.2018.07.008.
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- A. R. Pinho; M. J. Rocha; G. Alves; A. C. Falcão; A. C. Fortuna. "Development and validation of an HPLC-FLD technique for
colistin quantification and its plasma monitoring in hospitalized patients". Analytical Methods (2018): https://doi.org/10.1039/C7AY02585H.
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of new drug candidates: Focus on in vivo pharmaco-toxicological assays based on the rotarod performance test". Journal
of Pharmacy and Pharmaceutical Sciences 21 1 (2018): 110-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044151077&partnerID=MN8TOARS.
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colistin quantification and its plasma monitoring in hospitalized patients". Analytical Methods 10 3 (2018): 389-396.
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- Ferreira, A.; Rodrigues, M.; Fortuna, A.; Falcão, A.; Alves, G.. "Flavonoid compounds as reversing agents of the P-glycoprotein-mediated
multidrug resistance: An in vitro evaluation with focus on antiepileptic drugs". Food Research International 103 (2018):
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10.1016/j.foodres.2017.10.010
- Ventura, S.; Rodrigues, M.; Falcão, A.; Alves, G.. "Evaluation of the effects of Citrus aurantium (bitter orange) extract
on lamotrigine pharmacokinetics: Insights from in vivo studies in rats". Food and Chemical Toxicology 121 (2018): 166-172.
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10.1016/j.fct.2018.08.069
- Gidal, B.E.; Jacobson, M.P.; Ben-Menachem, E.; Carreño, M.; Blum, D.; Soares-da-Silva, P.; Falcão, A.; et al. "Exposure-safety
and efficacy response relationships and population pharmacokinetics of eslicarbazepine acetate". Acta Neurologica Scandinavica
138 3 (2018): 203-211. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046404680&partnerID=MN8TOARS.
10.1111/ane.12950
- Gonçalves, J.; Alves, G.; Bicker, J.; Falcão, A.; Fortuna, A.. "Development and full validation of an innovative HPLC-diode
array detection technique to simultaneously quantify lacosamide, levetiracetam and zonisamide in human plasma". Bioanalysis
10 8 (2018): 541-557. http://www.scopus.com/inward/record.url?eid=2-s2.0-85046784180&partnerID=MN8TOARS.
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- Ventura, S.; Rodrigues, M.; Falcão, A.; Alves, G.. "Effects of Paullinia cupana extract on lamotrigine pharmacokinetics in
rats: A herb-drug interaction on the gastrointestinal tract with potential clinical impact". Food and Chemical Toxicology
115 (2018): 170-177. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043505393&partnerID=MN8TOARS.
10.1016/j.fct.2018.03.011
- Bicker, J.; Alves, G.; Fortuna, A.; Soares-da-Silva, P.; Falcão, A.. "In vitro assessment of the interactions of dopamine
ß-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein". European Journal of Pharmaceutical
Sciences 117 (2018): 35-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041551169&partnerID=MN8TOARS.
10.1016/j.ejps.2018.02.006
- Ventura, S.; Rodrigues, M.; Falcão, A.; Alves, G.. "Safety evidence on the administration of Fucus vesiculosus L. (bladderwrack)
extract and lamotrigine: data from pharmacokinetic studies in the rat". Drug and Chemical Toxicology (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85055292875&partnerID=MN8TOARS.
10.1080/01480545.2018.1518454
- Gonçalves, J.; Bicker, J.; Alves, G.; Fortuna, A.; Falcão, A.. "Relevance of breast cancer resistance protein to brain distribution
and central acting drugs: A pharmacokinetic perspective". Current Drug Metabolism 19 12 (2018): 1021-1041. http://www.scopus.com/inward/record.url?eid=2-s2.0-85055614533&partnerID=MN8TOARS.
10.2174/1389200219666180629121033
- Amílcar Falcão. "Pharmacokinetics of opicapone, a third-generation COMT inhibitor, after single and multiple oral administration:
A comparative study in the rat". Toxicology and applied pharmacology (2017): https://doi.org/10.1016/j.taap.2017.03.013.
10.1016/j.taap.2017.03.013
- Amílcar Falcão. "Early preclinical evaluation of dihydropyrimidin(thi)ones as potential anticonvulsant drug candidates". European
journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2017): https://doi.org/10.1016/j.ejps.2017.03.014.
10.1016/j.ejps.2017.03.014
- Amílcar Falcão. "Intranasal delivery of ciprofloxacin to rats: A topical approach using a thermoreversible in situ gel". European
journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2017): https://doi.org/10.1016/j.ejps.2016.10.033.
10.1016/j.ejps.2016.10.033
- Amílcar Falcão. "Effect of opicapone multiple-dose regimens on levodopa pharmacokinetics". British journal of clinical
pharmacology (2017): https://doi.org/10.1111/bcp.13156.
10.1111/bcp.13156
- Amílcar Falcão. "A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone,
a novel COMT inhibitor, in rat". Neuropharmacology (2017): https://doi.org/10.1016/j.neuropharm.2017.07.019.
10.1016/j.neuropharm.2017.07.019
- Amílcar Falcão. "Determination of catecholamines and endogenous related compounds in rat brain tissue exploring their native
fluorescence and liquid chromatography". Journal of chromatography. B, Analytical technologies in the biomedical and life
sciences (2017): https://doi.org/10.1016/j.jchromb.2017.02.028.
10.1016/j.jchromb.2017.02.028
- Amílcar Falcão. "In vitro screening of dual flavonoid combinations for reversing P-glycoprotein-mediated multidrug resistance:
Focus on antiepileptic drugs". Food and chemical toxicology : an international journal published for the British Industrial
Biological Research Association (2017): https://doi.org/10.1016/j.fct.2017.11.004.
10.1016/j.fct.2017.11.004
- Amílcar Falcão. "On ciprofloxacin concentration in chronic rhinosinusitis". Acta otorrinolaringologica espanola (2017):
https://doi.org/10.1016/j.otorri.2017.06.008.
10.1016/j.otorri.2017.06.008
- Amílcar Falcão. "Steroidal oximes: useful compounds with antitumor activities". Current medicinal chemistry (2017):
https://doi.org/10.2174/0929867324666171003115400.
10.2174/0929867324666171003115400
- Amílcar Falcão. "Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders". Mini reviews
in medicinal chemistry (2017): https://doi.org/10.2174/1389557517666161111110121.
10.2174/1389557517666161111110121
- Amílcar Falcão. "Screening of pharmacokinetic properties of fifty dihydropyrimidin(thi)one derivatives using a combo of in
vitro and in silico assays". European journal of pharmaceutical sciences : official journal of the European Federation
for Pharmaceutical Sciences (2017): https://doi.org/10.1016/j.ejps.2017.08.023.
10.1016/j.ejps.2017.08.023
- Amílcar Falcão. "Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution
of Catechol-O-Methyltransferase Inhibitors". Drug metabolism and disposition: the biological fate of chemicals (2017):
https://doi.org/10.1124/dmd.117.077883.
10.1124/dmd.117.077883
- Amílcar Falcão. "Influence of the dual combination of silymarin and (-)-epigallocatechin gallate, natural dietary flavonoids,
on the pharmacokinetics of oxcarbazepine in rats". Food and chemical toxicology : an international journal published for
the British Industrial Biological Research Association (2017): https://doi.org/10.1016/j.fct.2017.06.015.
10.1016/j.fct.2017.06.015
- Amílcar Falcão. "Dendritic cell-based immunotherapy: a basic review and recent advances". Immunologic research (2017):
https://doi.org/10.1007/s12026-017-8931-1.
10.1007/s12026-017-8931-1
- Amílcar Falcão. "Intranasal Delivery of Topically-Acting Levofloxacin to Rats: a Proof-of-Concept Pharmacokinetic Study".
Pharmaceutical research (2017): https://doi.org/10.1007/s11095-017-2232-1.
10.1007/s11095-017-2232-1
- Amílcar Falcão. "Calprotectin and the Magnitude of Antibodies to Infliximab in Clinically-stable Ulcerative Colitis Patients
are More Relevant Than Infliximab Trough Levels and Pharmacokinetics for Therapeutic Escalation". EBioMedicine (2017):
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10.1016/j.ebiom.2017.06.004
- Amílcar Falcão. "Reliability of body-weight scalars on the assessment of propofol induction dose in obese patients". Acta
anaesthesiologica Scandinavica (2017): https://doi.org/10.1111/aas.13039.
10.1111/aas.13039
- Amílcar Falcão. "Therapeutic Drug Monitoring of Fluoxetine, Norfluoxetine and Paroxetine: A New Tool Based on Microextraction
by Packed Sorbent Coupled to Liquid Chromatography". Journal of analytical toxicology (2017): https://doi.org/10.1093/jat/bkx043.
10.1093/jat/bkx043
- Ventura, S.; Rodrigues, M.; Pousinho, S.; Falcão, A.; Alves, G.. "Determination of lamotrigine in human plasma and saliva
using microextraction by packed sorbent and high performance liquid chromatography–diode array detection: An innovative bioanalytical
tool for therapeutic drug monitoring". Microchemical Journal 130 (2017): 221-228. http://www.scopus.com/inward/record.url?eid=2-s2.0-84991000716&partnerID=MN8TOARS.
10.1016/j.microc.2016.09.007
- Joana Bicker; Gilberto Alves; Ana Fortuna; Patrício Soares-da-Silva; Amílcar Falcão. "A new PAMPA model using an in-house
brain lipid extract for screening the blood–brain barrier permeability of drug candidates". International Journal of Pharmaceutics
501 1-2 (2016): 102-111. https://doi.org/10.1016%2Fj.ijpharm.2016.01.074.
10.1016/j.ijpharm.2016.01.074
- Rodrigues, A.T.; Ferreira, M.; Piñeiro-Lamas, M.; Falcão, A.; Figueiras, A.; Herdeiro, M.T.. "Determinants of physician antibiotic
prescribing behavior: A 3 year cohort study in Portugal". Current Medical Research and Opinion 32 5 (2016): 949-957.
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10.1185/03007995.2016.1154520
- Teixeira Rodrigues, A.; Ferreira, M.; Roque, F.; Falcão, A.; Ramalheira, E.; Figueiras, A.; Herdeiro, M.T.. "Physicians' attitudes
and knowledge concerning antibiotic prescription and resistance: Questionnaire development and reliability". BMC Infectious
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10.1186/s12879-015-1332-y
- Ferreira, A.; Rodrigues, M.; Falcão, A.; Alves, G.. "HPLC–DAD Method for the Quantification of Carbamazepine, Oxcarbazepine
and their Active Metabolites in HepaRG Cell Culture Samples". Chromatographia 79 9-10 (2016): 581-590. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961208349&partnerID=MN8TOARS.
10.1007/s10337-016-3063-7
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ex vivo fosphenytoin nasal bioconversion/permeability evaluation method". European Journal of Pharmaceutical Sciences
89 (2016): 61-72. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964613921&partnerID=MN8TOARS.
10.1016/j.ejps.2016.04.018
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"Treatment with subcutaneous and transdermal fentanyl: Results from a population pharmacokinetic study in cancer patients".
European Journal of Clinical Pharmacology 72 4 (2016): 459-467. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954317744&partnerID=MN8TOARS.
10.1007/s00228-015-2005-x
- Amílcar Falcão. "An easy-to-use liquid chromatography assay for the analysis of lamotrigine in rat plasma and brain samples
using microextraction by packed sorbent: Application to a pharmacokinetic study". Journal of chromatography. B, Analytical
technologies in the biomedical and life sciences (2016): https://doi.org/10.1016/j.jchromb.2016.09.032.
10.1016/j.jchromb.2016.09.032
- Amílcar Falcão. "Gastrodia elata and epilepsy: Rationale and therapeutic potential". Phytomedicine : international journal
of phytotherapy and phytopharmacology (2016): https://doi.org/10.1016/j.phymed.2016.09.001.
10.1016/j.phymed.2016.09.001
- Amílcar Falcão. "Pharmacist Interventions in the Management of Type 2 Diabetes Mellitus: A Systematic Review of Randomized
Controlled Trials". Journal of managed care & specialty pharmacy (2016): https://doi.org/10.18553/jmcp.2016.22.5.493.
10.18553/jmcp.2016.22.5.493
- Ferreira, A.; Rodrigues, M.; Fortuna, A.; Falcão, A.; Alves, G.. "Huperzine A from Huperzia serrata: a review of its sources,
chemistry, pharmacology and toxicology". Phytochemistry Reviews 15 1 (2016): 51-85. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957433866&partnerID=MN8TOARS.
10.1007/s11101-014-9384-y
- Amílcar Falcão. "Drug-metabolizing Enzymes and Efflux Transporters in Nasal Epithelium: Influence on the Bioavailability of
Intranasally Administered Drugs". Current drug metabolism (2016): https://doi.org/10.2174/1389200217666160406120509.
10.2174/1389200217666160406120509
- Amílcar Falcão. "Can the CEIBA Cocktail Designed for Human Cytochrome P450 Enzymes be Used in the Rat for Drug Interaction
Studies?". Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences,
Societe canadienne des sciences pharmaceutiques (2016): https://doi.org/10.18433/J3D313.
10.18433/j3d313
- Amílcar Falcão. "A Rapid and Sensitive HPLC-DAD Assay to Quantify Lamotrigine, Phenytoin and Its Main Metabolite in Samples
of Cultured HepaRG Cells". Journal of chromatographic science (2016): https://doi.org/10.1093/chromsci/bmw088.
10.1093/chromsci/bmw088
- Magalhães, P.; De Andrés, F.; Falcão, A.; Llerena, A.; Alves, G.. "Can the CEIBA cocktail designed for human cytochrome P450
enzymes be used in the rat for drug interaction studies?". Journal of Pharmacy and Pharmaceutical Sciences 19 4 (2016):
520-529. http://www.scopus.com/inward/record.url?eid=2-s2.0-85009895634&partnerID=MN8TOARS.
- Matias, M.; Campos, G.; Santos, A.O.; Falcão, A.; Silvestre, S.; Alves, G.. "Potential antitumoral 3,4-dihydropyrimidin-2-(1:
H)-ones: synthesis, in vitro biological evaluation and QSAR studies". RSC Advances 6 88 (2016): 84943-84958. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987657546&partnerID=MN8TOARS.
10.1039/c6ra14596e
- Constantino J; Gomes C; Falcão A; Cruz MT; Neves BM. "Antitumor dendritic cell-based vaccines: lessons from 20 years of clinical
trials and future perspectives.". (2015): http://europepmc.org/abstract/med/26297944.
10.1016/j.trsl.2015.07.008
- José-Francisco Rocha; Joaquim J. Ferreira; Amílcar Falcão; Ana Santos; Roberto Pinto; Teresa Nunes; Luis Almeida; Patrício
Soares-da-Silva. "Effect of three single-dose regimens of opicapone on levodopa pharmacokinetics, catechol- O -methyltransferase
activity and motor response in patients with Parkinson's disease". Clinical Pharmacology in Drug Development (2015):
n/a-n/a. http://dx.doi.org/10.1002/cpdd.217.
10.1002/cpdd.217
- Gonçalves D; Alves G; Fortuna A; Soares-da-Silva P; Falcão A. "Development of a liquid chromatography assay for the determination
of opicapone and BIA 9-1079 in rat matrices.". (2015): http://europepmc.org/abstract/med/26147707.
10.1002/bmc.3550
- Amílcar Falcão; José Francisco Rocha; Ana Santos; Teresa Nunes; Patrício Soares-da-Silva. "Opicapone pharmacokinetics and
pharmacodynamics comparison between healthy Japanese and matched Caucasian subjects". Clinical Pharmacology in Drug Development
(2015): n/a-n/a. http://dx.doi.org/10.1002/cpdd.213.
10.1002/cpdd.213
- Ferreira, A.; Pousinho, S.; Fortuna, A.; Falcão, A.; Alves, G.. "Flavonoid compounds as reversal agents of the P-glycoprotein-mediated
multidrug resistance: biology, chemistry and pharmacology". Phytochemistry Reviews 14 2 (2015): 233-272. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939874562&partnerID=MN8TOARS.
10.1007/s11101-014-9358-0
- Amílcar Falcão. "Assessment of the efficacy and safety of eslicarbazepine acetate in acute mania and prevention of recurrence:
experience from multicentre, double-blind, randomised phase II clinical studies in patients with bipolar disorder I". Journal
of affective disorders (2015): https://doi.org/10.1016/j.jad.2014.11.013.
10.1016/j.jad.2014.11.013
- Amílcar Falcão. "Direct nose-to-brain delivery of lamotrigine following intranasal administration to mice". International
journal of pharmaceutics (2015): https://doi.org/10.1016/j.ijpharm.2015.05.021.
10.1016/j.ijpharm.2015.05.021
- Amílcar Falcão. "Effect of opicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity and motor fluctuations
in patients with Parkinson's disease". European journal of neurology (2015): https://doi.org/10.1111/ene.12666.
10.1111/ene.12666
- Pinto, R.; l'Hostis, P.; Patat, A.; Homery, M..-C.; Falcão, A.; Nunes, T.; Rocha, J.-F.; Soares-da-Silva, P.. "Evaluation
of opicapone on cardiac repolarization in a thorough QT/QTc study". Clinical Pharmacology in Drug Development 4 6 (2015):
454-462. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954396335&partnerID=MN8TOARS.
10.1002/cpdd.188
- Vaz-da-Silva, M.; Rocha, J.-F.; Lacroix, P.; Falcão, A.; Almeida, L.; Soares-da-Silva, P.. "Cardiac safety profile of etamicastat,
a novel peripheral selective dopamine-ß-hydroxylase inhibitor in non-human primates, human young and elderly healthy volunteers
and hypertensive patients". IJC Metabolic and Endocrine 7 (2015): 10-24. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928249727&partnerID=MN8TOARS.
10.1016/j.ijcme.2015.03.002
- Fortuna, Ana; Tavares, Ana; Couceiro, Paula; Alves, Gilberto; Falcao, Amilcar. "Medication regimen complexity evaluation in
a hypertensive portuguese population". International Journal of Clinical Pharmacy (2015): https://publons.com/wos-op/publon/53241197/.
- Fortuna, Ana; Magalhaes, Paulo; Rodrigues, Marcio; Llerena, Adrian; Alves, Gilberto; Falcao, Amilcar. "A new MEPS/HPLC assay
to quantify venlafaxine and its main metabolite in human plasma". International Journal of Clinical Pharmacy (2015):
https://publons.com/wos-op/publon/28270670/.
- Grunze H; Kotlik E; Costa R; Nunes T; Falcão A; Almeida L; Soares-da-Silva P. "Assessment of the efficacy and safety of eslicarbazepine
acetate in acute mania and prevention of recurrence: Experience from multicentre, double-blind, randomised phase II clinical
studies in patients with bipolar disorder I.". (2014): http://europepmc.org/abstract/med/25484179.
- Magalhães J; Rodrigues AT; Roque F; Figueiras A; Falcão A; Herdeiro MT. "Use of off-label and unlicenced drugs in hospitalised
paediatric patients: a systematic review.". (2014): http://europepmc.org/abstract/med/25318905.
10.1007/s00228-014-1768-9
- Magalhães P; Alves G; LLerena A; Falcão A. "Clinical drug-drug interactions: focus on venlafaxine.". (2014): http://europepmc.org/abstract/med/24964257.
10.1515/dmdi-2014-0011
- Amílcar Falcão. "Intranasal delivery of systemic-acting drugs: small-molecules and biomacromolecules". European journal
of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
(2014): https://doi.org/10.1016/j.ejpb.2014.03.004.
10.1016/j.ejpb.2014.03.004
- Amílcar Falcão. "Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems:
a review". European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische
Verfahrenstechnik e.V (2014): https://doi.org/10.1016/j.ejpb.2014.03.012.
10.1016/j.ejpb.2014.03.012
- Amílcar Falcão. "HepaRG cell line as an in vitro model for screening drug-drug interactions mediated by metabolic induction:
amiodarone used as a model substance". Toxicology in vitro : an international journal published in association with BIBRA
(2014): https://doi.org/10.1016/j.tiv.2014.08.004.
10.1016/j.tiv.2014.08.004
- Amílcar Falcão. "Liquid chromatographic assay based on microextraction by packed sorbent for therapeutic drug monitoring of
carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin and the active metabolites carbamazepine-10,11-epoxide
and licarbazepine". Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (2014):
https://doi.org/10.1016/j.jchromb.2014.09.010.
10.1016/j.jchromb.2014.09.010
- Sousa J; Alves G; Fortuna A; Falcão A. "Third and fourth generation fluoroquinolone antibacterials: a systematic review of
safety and toxicity profiles.". (2014): http://europepmc.org/abstract/med/24410307.
- Rodrigues M; Alves G; Francisco J; Fortuna A; Falcão A. "Herb-drug pharmacokinetic interaction between carica papaya extract
and amiodarone in rats.". (2014): http://europepmc.org/abstract/med/25224345.
- Sousa, J.; Alves, G.; Fortuna, A.; Falcão, A.. "Third and fourth generation fluoroquinolone antibacterials: A systematic review
of safety and toxicity profiles". Current Drug Safety 9 2 (2014): 89-105. http://www.scopus.com/inward/record.url?eid=2-s2.0-84904717224&partnerID=MN8TOARS.
- Amílcar Falcão. "Venlafaxine pharmacokinetics focused on drug metabolism and potential biomarkers". Drug metabolism and
drug interactions (2014): https://doi.org/10.1515/dmdi-2013-0053.
10.1515/dmdi-2013-0053
- Amílcar Falcão. "Effect of moderate liver impairment on the pharmacokinetics of opicapone". European journal of clinical
pharmacology (2014): https://doi.org/10.1007/s00228-013-1602-9.
10.1007/s00228-013-1602-9
- Amílcar Falcão. "Effect of opicapone and entacapone upon levodopa pharmacokinetics during three daily levodopa administrations".
European journal of clinical pharmacology (2014): https://doi.org/10.1007/s00228-014-1701-2.
10.1007/s00228-014-1701-2
- Amílcar Falcão. "Intranasal administration of carbamazepine to mice: a direct delivery pathway for brain targeting". European
journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences (2014): https://doi.org/10.1016/j.ejps.2014.04.019.
10.1016/j.ejps.2014.04.019
- Amílcar Falcão. "First MEPS/HPLC assay for the simultaneous determination of venlafaxine and O-desmethylvenlafaxine in human
plasma". Bioanalysis (2014): https://doi.org/10.4155/bio.14.222.
10.4155/bio.14.222
- Amílcar Falcão. "Chiral chromatographic resolution of antiepileptic drugs and their metabolites: a challenge from the optimization
to the application". Biomedical chromatography : BMC (2014): https://doi.org/10.1002/bmc.3004.
10.1002/bmc.3004
- Amílcar Falcão. "Third and fourth generation fluoroquinolone antibacterials: a systematic review of safety and toxicity profiles".
Current drug safety (2014): https://doi.org/10.2174/1574886308666140106154754.
10.2174/1574886308666140106154754
- Rodrigues, M.; Alves, G.; Francisco, J.; Fortunaa, A.; Falcão, A.. "Herb-drug pharmacokinetic interaction between carica papaya
extract and amiodarone in rats". Journal of Pharmacy and Pharmaceutical Sciences 17 3 (2014): 302-315. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905030569&partnerID=MN8TOARS.
- Amílcar Falcão. "Efficacy and safety of eslicarbazepine acetate as add-on treatment in patients with focal-onset seizures:
integrated analysis of pooled data from double-blind phase III clinical studies". Epilepsia (2013): https://doi.org/10.1111/j.1528-1167.2012.03605.x.
10.1111/j.1528-1167.2012.03605.x
- Amílcar Falcão. "First liquid chromatography method for the simultaneous determination of levofloxacin, pazufloxacin, gatifloxacin,
moxifloxacin and trovafloxacin in human plasma". Journal of chromatography. B, Analytical technologies in the biomedical
and life sciences (2013): https://doi.org/10.1016/j.jchromb.2013.04.036.
10.1016/j.jchromb.2013.04.036
- Amílcar Falcão. "Long-term safety and efficacy of eslicarbazepine acetate as adjunctive therapy in the treatment of partial-onset
seizures in adults with epilepsy: results of a 1-year open-label extension study". Epilepsy research (2013): https://doi.org/10.1016/j.eplepsyres.2012.07.014.
10.1016/j.eplepsyres.2012.07.014
- Amílcar Falcão. "A rapid HPLC method for the simultaneous determination of amiodarone and its major metabolite in rat plasma
and tissues: a useful tool for pharmacokinetic studies". Journal of chromatographic science (2013): https://doi.org/10.1093/chromsci/bms149.
10.1093/chromsci/bms149
- Amílcar Falcão. "Bioequivalence of eslicarbazepine acetate from two different sources of its active product ingredient in
healthy subjects". Drugs in R&D (2013): http://europepmc.org/articles/PMC3689905.
10.1007/s40268-013-0016-6
- Amílcar Falcão. "A critical review of microextraction by packed sorbent as a sample preparation approach in drug bioanalysis".
Bioanalysis (2013): https://doi.org/10.4155/bio.13.92.
10.4155/bio.13.92
- Amílcar Falcão. "Effect of eslicarbazepine acetate on the pharmacokinetics of a combined ethinylestradiol/levonorgestrel oral
contraceptive in healthy women". Epilepsy research (2013): https://doi.org/10.1016/j.eplepsyres.2013.02.020.
10.1016/j.eplepsyres.2013.02.020
- Amílcar Falcão. "First liquid chromatographic method for the simultaneous determination of amiodarone and desethylamiodarone
in human plasma using microextraction by packed sorbent (MEPS) as sample preparation procedure". Journal of chromatography.
B, Analytical technologies in the biomedical and life sciences (2013): https://doi.org/10.1016/j.jchromb.2012.11.028.
10.1016/j.jchromb.2012.11.028
- Amílcar Falcão. "Pharmacokinetics, pharmacodynamics and tolerability of opicapone, a novel catechol-O-methyltransferase inhibitor,
in healthy subjects: prediction of slow enzyme-inhibitor complex dissociation of a short-living and very long-acting inhibitor".
Clinical pharmacokinetics (2013): https://doi.org/10.1007/s40262-012-0024-7.
10.1007/s40262-012-0024-7
- Amílcar Falcão. "Understanding physician antibiotic prescribing behaviour: a systematic review of qualitative studies". International
journal of antimicrobial agents (2013): https://doi.org/10.1016/j.ijantimicag.2012.09.003.
10.1016/j.ijantimicag.2012.09.003
- Amílcar Falcão. "Herb-drug interaction of Fucus vesiculosus extract and amiodarone in rats: a potential risk for reduced bioavailability
of amiodarone in clinical practice". Food and chemical toxicology : an international journal published for the British
Industrial Biological Research Association (2013): https://doi.org/10.1016/j.fct.2012.11.012.
10.1016/j.fct.2012.11.012
- Amílcar Falcão. "Investigating herb-drug interactions: the effect of Citrus aurantium fruit extract on the pharmacokinetics
of amiodarone in rats". Food and chemical toxicology : an international journal published for the British Industrial Biological
Research Association (2013): https://doi.org/10.1016/j.fct.2013.07.041.
10.1016/j.fct.2013.07.041
- Amílcar Falcão. "Opicapone: a short lived and very long acting novel catechol-O-methyltransferase inhibitor following multiple
dose administration in healthy subjects". British journal of clinical pharmacology (2013): http://europepmc.org/articles/PMC3853535.
10.1111/bcp.12081
- Amílcar Falcão. "Pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine at steady state in healthy
volunteers". Epilepsia (2013): https://doi.org/10.1111/epi.12242.
10.1111/epi.12242
- Amílcar Falcão. "Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: new
set of data for predictive in silico ADME models". Epilepsy research (2013): https://doi.org/10.1016/j.eplepsyres.2013.08.013.
10.1016/j.eplepsyres.2013.08.013
- Amílcar Falcão. "Liquid chromatographic methods for the quantification of catecholamines and their metabolites in several
biological samples--a review". Analytica chimica acta (2013): https://doi.org/10.1016/j.aca.2012.12.030.
10.1016/j.aca.2012.12.030
- Amílcar Falcão. "Effect of repeated administration of eslicarbazepine acetate on the pharmacokinetics of simvastatin in healthy
subjects". Epilepsy research (2013): https://doi.org/10.1016/j.eplepsyres.2013.04.009.
10.1016/j.eplepsyres.2013.04.009
- Duarte, S.C.; Almeida, A.M.; Teixeira, A.S.; Pereira, A.L.; Falcão, A.C.; Pena, A.; Lino, C.M.. "Aflatoxin M1 in marketed
milk in Portugal: Assessment of human and animal exposure". Food Control 30 2 (2013): 411-417. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867590060&partnerID=MN8TOARS.
10.1016/j.foodcont.2012.08.002
- Amílcar Falcão. "Steady-state plasma and cerebrospinal fluid pharmacokinetics and tolerability of eslicarbazepine acetate
and oxcarbazepine in healthy volunteers". Epilepsia (2013): https://doi.org/10.1111/j.1528-1167.2012.03595.x.
10.1111/j.1528-1167.2012.03595.x
- Amílcar Falcão. "First HPLC-UV method for rapid and simultaneous quantification of phenobarbital, primidone, phenytoin, carbamazepine,
carbamazepine-10,11-epoxide, 10,11-trans-dihydroxy-10,11-dihydrocarbamazepine, lamotrigine, oxcarbazepine and licarbazepine
in human plasma". Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (2013):
https://doi.org/10.1016/j.jchromb.2013.02.026.
10.1016/j.jchromb.2013.02.026
- Amílcar Falcão. "An HPLC-DAD method for the simultaneous quantification of opicapone (BIA 9-1067) and its active metabolite
in human plasma". The Analyst (2013): https://doi.org/10.1039/c3an36671e.
10.1039/c3an36671e
- Herdeiro MT; Ribeiro-Vaz I; Ferreira M; Polónia J; Falcão A; Figueiras A. "Workshop- and telephone-based interventions to
improve adverse drug reaction reporting: a cluster-randomized trial in Portugal.". (2012): http://europepmc.org/abstract/med/22788235.
10.2165/11599750-000000000-00000
- Serralheiro, A.; Alves, G.; Falcão, A.. "Bioanalysis of small-molecule drugs in nasal and paranasal tissues and secretions:
Current status and perspectives". Central European Journal of Chemistry 10 3 (2012): 686-702. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867098752&partnerID=MN8TOARS.
10.2478/s11532-012-0021-6
- Amílcar Falcão. "Analytical methods for determination of new fluoroquinolones in biological matrices and pharmaceutical formulations
by liquid chromatography: a review". Analytical and bioanalytical chemistry (2012): https://doi.org/10.1007/s00216-011-5706-8.
10.1007/s00216-011-5706-8
- Amílcar Falcão. "Single-dose tolerability, pharmacokinetics, and pharmacodynamics of etamicastat (BIA 5-453), a new dopamine
ß-hydroxylase inhibitor, in healthy subjects". Journal of clinical pharmacology (2012): https://doi.org/10.1177/0091270010390805.
10.1177/0091270010390805
- Amílcar Falcão. "Optimization of a parallel artificial membrane permeability assay for the fast and simultaneous prediction
of human intestinal absorption and plasma protein binding of drug candidates: application to dibenz[b,f]azepine-5-carboxamide
derivatives". Journal of pharmaceutical sciences (2012): https://doi.org/10.1002/jps.22796.
10.1002/jps.22796
- Amílcar Falcão. "Pharmacokinetics, drug interactions and exposure-response relationship of eslicarbazepine acetate in adult
patients with partial-onset seizures: population pharmacokinetic and pharmacokinetic/pharmacodynamic analyses". CNS drugs
(2012): https://doi.org/10.2165/11596290-000000000-00000.
10.2165/11596290-000000000-00000
- Amílcar Falcão. "A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine,
R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain". Biomedical
chromatography : BMC (2012): https://doi.org/10.1002/bmc.1670.
10.1002/bmc.1670
- Amílcar Falcão. "Bioanalytical chromatographic methods for the determination of catechol-O-methyltransferase inhibitors in
rodents and human samples: a review". Analytica chimica acta (2012): https://doi.org/10.1016/j.aca.2011.10.026.
10.1016/j.aca.2011.10.026
- Amílcar Falcão. "Evaluation of the permeability and P-glycoprotein efflux of carbamazepine and several derivatives across
mouse small intestine by the Ussing chamber technique". Epilepsia (2012): https://doi.org/10.1111/j.1528-1167.2012.03409.x.
10.1111/j.1528-1167.2012.03409.x
- Amílcar Falcão. "Workshop- and telephone-based interventions to improve adverse drug reaction reporting: a cluster-randomized
trial in Portugal". Drug safety (2012): https://doi.org/10.2165/11599750-000000000-00000.
10.1007/bf03261962
- Sousa, J.; Alves, G.; Abrantes, J.; Fortuna, A.; Falcão, A.. "Erratum: Analytical methods for determination of new fluoroquinolones
in biological matrices and pharmaceutical formulations by liquid chromatography: A review (Analytical and Bioanalytical Chemistry
DOI: 10.1007/s00216-011-5706-8)". Analytical and Bioanalytical Chemistry 403 5 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84861233835&partnerID=MN8TOARS.
10.1007/s00216-012-5913-y
- Amílcar Falcão. "Herb-Drug Interaction of Paullinia cupana (Guarana) Seed Extract on the Pharmacokinetics of Amiodarone in
Rats". Evidence-based Complementary and Alternative Medicine : eCAM (2012): http://europepmc.org/articles/PMC3523151.
10.1155/2012/428560
- Amílcar Falcão. "Pharmacokinetics and tolerability of etamicastat following single and repeated administration in elderly
versus young healthy male subjects: an open-label, single-center, parallel-group study". Clinical therapeutics (2011):
https://doi.org/10.1016/j.clinthera.2011.05.048.
10.1016/j.clinthera.2011.05.048
- Amílcar Falcão. "Pharmacokinetics of eslicarbazepine acetate at steady-state in adults with partial-onset seizures". Epilepsy
research (2011): https://doi.org/10.1016/j.eplepsyres.2011.05.013.
10.1016/j.eplepsyres.2011.05.013
- Amílcar Falcão. "In-vivo evaluation of prolonged release bilayer tablets of anti-Parkinson drugs in Göttingen minipigs". The
Journal of pharmacy and pharmacology (2011): https://doi.org/10.1111/j.2042-7158.2011.01278.x.
10.1111/j.2042-7158.2011.01278.x
- Amílcar Falcão. "A chiral HPLC-UV method for the quantification of dibenz[b,f]azepine-5-carboxamide derivatives in mouse plasma
and brain tissue: eslicarbazepine acetate, carbamazepine and main metabolites". Journal of separation science (2011):
https://doi.org/10.1002/jssc.201100099.
10.1002/jssc.201100099
- Amílcar Falcão. "Development and validation of a fast isocratic liquid chromatography method for the simultaneous determination
of norfloxacin, lomefloxacin and ciprofloxacin in human plasma". Biomedical chromatography : BMC (2011): https://doi.org/10.1002/bmc.1480.
10.1002/bmc.1480
- Ana Fortuna; Gilberto Alves; Amílcar Falcão. "In vitro and In vivo Relevance of the P-glycoprotein Probe Substrates in Drug
Discovery and Development: Focus on Rhodamine 123, Digoxin and Talinolol". JBB 01 02 (2011): http://dx.doi.org/10.4172/jbb.s2-001.
10.4172/jbb.s2-001
- Amílcar Falcão. "Effect of food on the pharmacokinetic profile of etamicastat (BIA 5-453)". Drugs in R&D (2011): http://europepmc.org/articles/PMC3585837.
10.2165/11587080-000000000-00000
- Amílcar Falcão. "Enantioselective assay for therapeutic drug monitoring of eslicarbazepine acetate: no interference with carbamazepine
and its metabolites". Therapeutic drug monitoring (2010): https://doi.org/10.1097/FTD.0b013e3181e5c855.
10.1097/ftd.0b013e3181e5c855
- Amílcar Falcão. "Pharmacokinetic interaction study between eslicarbazepine acetate and topiramate in healthy subjects". Current
medical research and opinion (2010): https://doi.org/10.1185/03007991003740861.
10.1185/03007991003740861
- Amílcar Falcão. "Binding of licarbazepine enantiomers to mouse and human plasma proteins". Biopharmaceutics & drug disposition
(2010): https://doi.org/10.1002/bdd.716.
10.1002/bdd.716
- Amílcar Falcão. "Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine,
eslicarbazepine acetate and their main metabolites in human plasma". Analytical and bioanalytical chemistry (2010):
https://doi.org/10.1007/s00216-010-3673-0.
10.1007/s00216-010-3673-0
- Amílcar Falcão. "Chronopharmacology of nebicapone, a new catechol-O-methyltransferase inhibitor". Current medical research
and opinion (2010): https://doi.org/10.1185/03007991003694472.
10.1185/03007991003694472
- Amílcar Falcão. "Usefulness of factor II and factor X as therapeutic markers in patients under chronic warfarin therapy".
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie (2010): https://doi.org/10.1016/j.biopha.2009.09.020.
10.1016/j.biopha.2009.09.020
- Amílcar Falcão. "Safety, tolerability, and pharmacokinetics of etamicastat, a novel dopamine-ß-hydroxylase inhibitor, in a
rising multiple-dose study in young healthy subjects". Drugs in R&D (2010): http://europepmc.org/articles/PMC3585840.
10.2165/11586310-000000000-00000
- Vaz-da-Silva, M.; Almeida, L.; Falcão, A.; Soares, E.; Maia, J.; Nunes, T.; Soares-da-Silva, P.. "Effect of eslicarbazepine
acetate on the steady-state pharmacokinetics and pharmacodynamics of warfarin in healthy subjects during a three-stage, open-label,
multiple-dose, single-period study.". Clinical therapeutics 32 1 (2010): 179-192. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952294567&partnerID=MN8TOARS.
- Amílcar Falcão. "Effect of eslicarbazepine acetate on the steady-state pharmacokinetics and pharmacodynamics of warfarin in
healthy subjects during a three-stage, open-label, multiple-dose, single-period study". Clinical therapeutics (2010):
https://doi.org/10.1016/j.clinthera.2010.01.014.
10.1016/j.clinthera.2010.01.014
- Amílcar Falcão. "Pharmacokinetic interaction study between eslicarbazepine acetate and lamotrigine in healthy subjects". Acta
neurologica Scandinavica (2010): https://doi.org/10.1111/j.1600-0404.2009.01233.x.
10.1111/j.1600-0404.2009.01233.x
- Alves, G.; Fortuna, A.; Sousa, J.; Direito, R.; Almeida, A.; Rocha, M.; Falcão, A.; Soares-Da-Silva, P.. "Enantioselective
assay for therapeutic drug monitoring of eslicarbazepine acetate: No interference with carbamazepine and its metabolites".
Therapeutic Drug Monitoring 32 4 (2010): 512-516. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955173774&partnerID=MN8TOARS.
10.1097/FTD.0b013e3181e5c855
- Rocha JF; Vaz-da-Silva M; Almeida L; Falcão A; Nunes T; Santos AT; Martins F; et al. "Effect of eslicarbazepine acetate on
the pharmacokinetics of metformin in healthy subjects.". (2009): http://europepmc.org/abstract/med/19356391.
- Pires, A.; Fortuna, A.; Alves, G.; Falcão, A.. "Intranasal drug delivery: How, why and what for?". Journal of Pharmacy
and Pharmaceutical Sciences 12 3 (2009): 288-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950358719&partnerID=MN8TOARS.
- Rocha, J.-F.; Vaz-da-Silva, M.; Almeida, L.; Falcão, A.; Nunes, T.; Santos, A.-T.; Martins, F.; et al. "Effect of eslicarbazepine
acetate on the pharmacokinetics of metformin in healthy subjects". International Journal of Clinical Pharmacology and Therapeutics
47 4 (2009): 255-261. http://www.scopus.com/inward/record.url?eid=2-s2.0-65549151370&partnerID=MN8TOARS.
- Pires A; Fortuna A; Alves G; Falcão A. "Intranasal drug delivery: how, why and what for?". (2009): http://europepmc.org/abstract/med/20067706.
- Amílcar Falcão. "Pharmacokinetic-pharmacodynamic interaction between nebicapone and controlled-release levodopa/benserazide:
a single-center, Phase I, double-blind, randomized, placebo-controlled, four-way crossover study in healthy subjects". Clinical
therapeutics (2009): https://doi.org/10.1016/j.clinthera.2009.10.019.
10.1016/j.clinthera.2009.10.019
- Amílcar Falcão. "Effect of eslicarbazepine acetate on the pharmacokinetics of digoxin in healthy subjects". Fundamental
& clinical pharmacology (2009): https://doi.org/10.1111/j.1472-8206.2009.00691.x.
10.1111/j.1472-8206.2009.00691.x
- Amílcar Falcão. "Pharmacokinetics of trans-resveratrol following repeated administration in healthy elderly and young subjects".
Journal of clinical pharmacology (2009): https://doi.org/10.1177/0091270009339191.
10.1177/0091270009339191
- Amílcar Falcão. "Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers".
Molecular nutrition & food research (2009): https://doi.org/10.1002/mnfr.200800177.
10.1002/mnfr.200800177
- Amílcar Falcão. "The maximal electroshock seizure (MES) model in the preclinical assessment of potential new antiepileptic
drugs". Methods and findings in experimental and clinical pharmacology (2009): https://doi.org/10.1358/mf.2009.31.2.1338414.
10.1358/mf.2009.31.2.1338414
- Alves, Gilberto; Nunes, Teresa; Fortuna, Ana; Serralheiro, Ana; Rodrigues, Marcio; Falcao, Amilcar; Soares-da-Silva, P.. "METABOLISM
AND LIVER PHARMACOKINETICS OF S- AND R-LICARBAZEPINE IN MICE AT THE STEADY-STATE". The Journal of Clinical Pharmacology
(2009): https://publons.com/wos-op/publon/7685906/.
- Alves, Gilberto; Nunes, Teresa; Fortuna, Ana; Serralheiro, Ana; Rodrigues, Marcio; Falcao, Amilcar; Soares-da-Silva, P.. "KIDNEY
DRUG EXPOSURE AFTER MULTIPLE-DOSE ADMINISTRATION OF S- AND R-LICARBAZEPINE TO MICE". The Journal of Clinical Pharmacology
(2009): https://publons.com/wos-op/publon/7685907/.
- Luis Almeida; Amílcar Falcão; Rui Coelho; António Albino-Teixeira; Patrício Soares-da-Silva. "The Role of Socioeconomic Conditions
and Psychological Factors in the Willingness to Volunteer for Phase I Studies". Pharm Med 22 6 (2008): 367-374. http://dx.doi.org/10.1007/bf03256734.
10.1007/bf03256734
- Almeida L; Falcão A; Vaz-da-Silva M; Coelho R; Albino-Teixeira A; Soares-da-Silva P. "Personality characteristics of volunteers
in Phase 1 studies and likelihood of reporting adverse events.". (2008): http://europepmc.org/abstract/med/18793588.
- Maia J; Almeida L; Falcão A; Soares E; Mota F; Potgieter MA; Potgieter JH; Soares-da-Silva P. "Effect of renal impairment
on the pharmacokinetics of eslicarbazepine acetate.". (2008): http://europepmc.org/abstract/med/18397682.
- Amílcar Falcão. "Disposition of eslicarbazepine acetate in the mouse after oral administration". Fundamental & clinical
pharmacology (2008): https://doi.org/10.1111/j.1472-8206.2008.00617.x.
10.1111/j.1472-8206.2008.00617.x
- Amílcar Falcão. "Effect of nebicapone on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects". European
journal of clinical pharmacology (2008): https://doi.org/10.1007/s00228-008-0534-2.
10.1007/s00228-008-0534-2
- Amílcar Falcão. "Pharmacokinetics, efficacy, and tolerability of eslicarbazepine acetate in children and adolescents with
epilepsy". Journal of clinical pharmacology (2008): https://doi.org/10.1177/0091270008319706.
10.1177/0091270008319706
- Amílcar Falcão. "Stereoselective disposition of S- and R-licarbazepine in mice". Chirality (2008): https://doi.org/10.1002/chir.20546.
10.1002/chir.20546
- Amílcar Falcão. "Pharmacokinetic-pharmacodynamic interaction between nebicapone, a novel catechol-o-methyltransferase inhibitor,
and controlled-release levodopa/carbidopa 200 mg/50 mg : randomized, double-blind, placebo-controlled, crossover study in
healthy subjects". Drugs in R&D (2008): https://doi.org/10.2165/0126839-200809060-00006.
10.2165/0126839-200809060-00006
- Amílcar Falcão. "Dosage form proportionality and food effect of the final tablet formulation of eslicarbazepine acetate: randomized,
open-label, crossover, single-centre study in healthy volunteers". Drugs in R&D (2008): https://doi.org/10.2165/0126839-200809060-00007.
10.2165/0126839-200809060-00007
- Mano, A.; Falcão, A.; Godinho, I.; Santos, J.; Leitão, F.; de Oliveira, C.; Caramona, M.. "CA-125 AUC as a predictor for epithelial
ovarian cancer relapse". Cancer Biomarkers 4 2 (2008): 73-81. http://www.scopus.com/inward/record.url?eid=2-s2.0-44049091669&partnerID=MN8TOARS.
- Amílcar Falcão. "Effects of nebicapone on levodopa pharmacokinetics, catechol-O-methyltransferase activity, and motor fluctuations
in patients with Parkinson disease". Clinical neuropharmacology (2008): https://doi.org/10.1097/wnf.0b013e3180645cb0.
10.1097/wnf.0b013e3180645cb0
- Almeida, L.; Falcão, A.; Coelho, R.; Albino-Teixeira, A.; Soares-Da-Silva, P.. "The role of socioeconomic conditions and psychological
factors in the willingness to volunteer for phase I studies". Pharmaceutical Medicine 22 6 (2008): 367-374. http://www.scopus.com/inward/record.url?eid=2-s2.0-69549116806&partnerID=MN8TOARS.
10.2165/1317117-200822060-00007
- Almeida, L.; Falcão, A.; Vaz-da-Silva, M.; Coelho, R.; Albino-Teixeira, A.; Soares-da-Silva, P.. "Personality characteristics
of volunteers in phase 1 studies and likelihood of reporting adverse events". International Journal of Clinical Pharmacology
and Therapeutics 46 7 (2008): 340-348. http://www.scopus.com/inward/record.url?eid=2-s2.0-47549084636&partnerID=MN8TOARS.
- Maia, J.; Almeida, L.; Falcão, A.; Soares, E.; Mota, F.; Potgieter, M.A.; Potgieter, J.H.; Soares-da-Silva, P.. "Effect of
renal impairment on the pharmacokinetics of eslicarbazepine acetate". International Journal of Clinical Pharmacology and
Therapeutics 46 3 (2008): 119-130. http://www.scopus.com/inward/record.url?eid=2-s2.0-44249105976&partnerID=MN8TOARS.
- Vaz-da-Silva, M.; Loureiro, A.I.; Falcao, A.; Nunes, T.; Rocha, J.-F.; Fernandes-Lopes, C.; Soares, E.; et al. "Effect of
food on the pharmacokinetic profile of trans-resveratrol". International Journal of Clinical Pharmacology and Therapeutics
46 11 (2008): 564-570. http://www.scopus.com/inward/record.url?eid=2-s2.0-56749153720&partnerID=MN8TOARS.
- Mano A; Falcão A; Godinho I; Santos J; Leitão F; de Oliveira C; Caramona M. "CA-125 AUC as a predictor for epithelial ovarian
cancer relapse.". (2008): http://europepmc.org/abstract/med/18503158.
- Amílcar Falcão. "Cyclodextrin multicomponent complexation and controlled release delivery strategies to optimize the oral
bioavailability of vinpocetine". Journal of pharmaceutical sciences (2007): https://doi.org/10.1002/jps.20294.
10.1002/jps.20294
- Amílcar Falcão. "Enantioselective HPLC-UV method for determination of eslicarbazepine acetate (BIA 2-093) and its metabolites
in human plasma". Biomedical chromatography : BMC (2007): https://doi.org/10.1002/bmc.858.
10.1002/bmc.858
- Amílcar Falcão. "Simultaneous and enantioselective liquid chromatographic determination of eslicarbazepine acetate, S-licarbazepine,
R-licarbazepine and oxcarbazepine in mouse tissue samples using ultraviolet detection". Analytica chimica acta (2007):
https://doi.org/10.1016/j.aca.2007.05.056.
10.1016/j.aca.2007.05.056
- Amílcar Falcão. "Performance of gentamicin population kinetic parameters in Portuguese neonates". Pharmacy world & science
: PWS (2007): https://doi.org/10.1007/s11096-007-9109-z.
10.1007/s11096-007-9109-z
- Fortuna, A.; Alves, G.; Falcão, A.. "The importance of permeability screening in drug discovery process: PAMPA, Caco-2 and
rat everted gut assays". Current Topics in Pharmacology 11 2 (2007): 63-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-56749128029&partnerID=MN8TOARS.
- Falcão, A.; Maia, J.; Almeida, L.; Mazur, D.; Gellert, M.; Soares-da-Silva, P.. "Effect of gender on the pharmacokinetics
of eslicarbazepine acetate (BIA 2-093), a new voltage-gated sodium channel blocker". Biopharmaceutics and Drug Disposition
28 5 (2007): 249-256. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547553692&partnerID=MN8TOARS.
10.1002/bdd.549
- Amílcar Falcão. "Lamotrigine pharmacokinetic evaluation in epileptic patients submitted to VEEG monitoring". European journal
of clinical pharmacology (2006): https://doi.org/10.1007/s00228-006-0144-9.
10.1007/s00228-006-0144-9
- Amílcar Falcão. "Effect of food on the pharmacokinetic profile of eslicarbazepine acetate (BIA 2-093)". Drugs in R&D
(2005): https://doi.org/10.2165/00126839-200506040-00002.
10.2165/00126839-200506040-00002
- Amílcar Falcão. "Lamotrigine pharmacokinetic/pharmacodynamic modelling in rats". Fundamental & clinical pharmacology
(2005): https://doi.org/10.1111/j.1472-8206.2005.00380.x.
10.1111/j.1472-8206.2005.00380.x
- Amílcar Falcão. "CA-125 AUC as a new prognostic factor for patients with ovarian cancer". Gynecologic oncology (2005):
https://doi.org/10.1016/j.ygyno.2005.01.040.
10.1016/j.ygyno.2005.01.040
- Amílcar Falcão. "Single-dose and steady-state pharmacokinetics of eslicarbazepine acetate (BIA 2-093) in healthy elderly and
young subjects". Journal of clinical pharmacology (2005): https://doi.org/10.1177/0091270005279364.
10.1177/0091270005279364
- Amílcar Falcão. "Bioavailability and bioequivalence of two enteric-coated formulations of omeprazole in fasting and fed conditions".
Clinical drug investigation (2005): https://doi.org/10.2165/00044011-200525060-00004.
10.2165/00044011-200525060-00004
- Amílcar Falcão. "CA 125 half-life breakpoint between a "good" and "poor" prognosis in patients with ovarian cancer". International
journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
(2005): https://doi.org/10.1016/j.ijgo.2004.12.028.
10.1016/j.ijgo.2004.12.028
- Amílcar Falcão. "Eslicarbazepine acetate (BIA 2-093) : relative bioavailability and bioequivalence of 50 mg/mL oral suspension
and 200mg and 800mg tablet formulations". Drugs in R&D (2005): https://doi.org/10.2165/00126839-200506050-00001.
10.2165/00126839-200506050-00001
- Castel-Branco, M.M.; Falcão, A.C.; Figueiredo, I.V.; Caramona, M.M.; Lanao, J.M.. "Neuropharmacokinetic characterization of
lamotrigine after its acute administration to rats". Methods and Findings in Experimental and Clinical Pharmacology
27 8 (2005): 539-545. http://www.scopus.com/inward/record.url?eid=2-s2.0-28444499339&partnerID=MN8TOARS.
10.1358/mf.2005.27.8.928299
- Amílcar Falcão. "Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/carbidopa".
Clinical neuropharmacology (2004): https://doi.org/10.1097/00002826-200401000-00007.
10.1097/00002826-200401000-00007
- Amílcar Falcão. "Lamotrigine kidney distribution in male rats following a single intraperitoneal dose". Fundamental & clinical
pharmacology (2004): https://doi.org/10.1046/j.0767-3981.2003.00210.x.
10.1046/j.0767-3981.2003.00210.x
- Rocha, M.J.; Almeida, A.M.; Afonso, E.; Martins, V.; Leitão, F.; Santos, J.; Falcão, A.C.. "Monitoring serum levels of gentamicin
in neonates | Recém-nascidos e monitorização sérica de gentamicina". Acta Medica Portuguesa 16 6 (2003): 389-394. http://www.scopus.com/inward/record.url?eid=2-s2.0-9644274017&partnerID=MN8TOARS.
- Marques Fernandes, C.; Ramos, P.; Celta Falcão, A.; Baptista Veiga, F.J.. "Hydrophilic and hydrophobic cyclodextrins in a
new sustained release oral formulation of nicardipine: In vitro evaluation and bioavailability studies in rabbits". Journal
of Controlled Release 88 1 (2003): 127-134. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037436015&partnerID=MN8TOARS.
10.1016/S0168-3659(02)00465-0
- Amílcar Falcão. "Relationship between plasma and brain levels and the anticonvulsant effect of lamotrigine in rats". European
journal of pharmacology (2003): https://doi.org/10.1016/j.ejphar.2003.09.065.
10.1016/j.ejphar.2003.09.065
- Amílcar Falcão. "Hydrophilic and hydrophobic cyclodextrins in a new sustained release oral formulation of nicardipine: in
vitro evaluation and bioavailability studies in rabbits". Journal of controlled release : official journal of the Controlled
Release Society (2003): https://doi.org/10.1016/S0168-3659(02)00465-0.
10.1016/s0168-3659(02)00465-0
- Rocha MJ; Almeida AM; Afonso E; Martins V; Leitão F; Santos J; Falcão AC. "[Monitoring serum levels of gentamicin in neonates]".
(2003): http://europepmc.org/abstract/med/15631849.
- Amílcar Falcão. "Pharmacokinetic-pharmacodynamic interaction between BIA 3-202, a novel COMT inhibitor, and levodopa/benserazide".
European journal of clinical pharmacology (2003): https://doi.org/10.1007/s00228-003-0680-5.
10.1007/s00228-003-0680-5
- Amílcar Falcão. "Influence of administration vehicles and drug formulations on the pharmacokinetic profile of lamotrigine
in rats". Fundamental & clinical pharmacology (2002): https://doi.org/10.1046/j.1472-8206.2002.00096.x.
10.1046/j.1472-8206.2002.00096.x
- Almeida, A.M.; Castel-Branco, M.M.; Falcão, A.C.. "Linear regression for calibration lines revisited: Weighting schemes for
bioanalytical methods". Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 774
2 (2002): 215-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037099575&partnerID=MN8TOARS.
10.1016/S1570-0232(02)00244-1
- Amílcar Falcão. "Population pharmacokinetics of digoxin in pediatric patients". Therapeutic drug monitoring (2002):
https://doi.org/10.1097/00007691-200212000-00010.
10.1097/00007691-200212000-00010
- Amílcar Falcão. "Linear regression for calibration lines revisited: weighting schemes for bioanalytical methods". Journal
of chromatography. B, Analytical technologies in the biomedical and life sciences (2002): https://doi.org/10.1016/S1570-0232(02)00244-1.
10.1016/s1570-0232(02)00244-1
- Castel-Branco, M.M.; Almeida, A.M.; Falcão, A.C.; Macedo, T.A.; Caramona, M.M.; Lopez, F.G.. "Lamotrigine analysis in blood
and brain by high-performance liquid chromatography". Journal of Chromatography B: Biomedical Sciences and Applications
755 1-2 (2001): 119-127. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035810756&partnerID=MN8TOARS.
10.1016/S0378-4347(01)00044-5
- Amílcar Falcão. "Population kinetics of tobramycin in neonates". Therapeutic drug monitoring (2001): https://doi.org/10.1097/00007691-200106000-00004.
10.1097/00007691-200106000-00004
- Amílcar Falcão. "Therapeutic monitoring of warfarin: the appropriate response marker". The Journal of pharmacy and pharmacology
(2000): https://doi.org/10.1211/0022357001777405.
10.1211/0022357001777405
- Amílcar Falcão. "The kinetic profile of gentamicin in premature neonates". The Journal of pharmacy and pharmacology
(2000): https://doi.org/10.1211/0022357001775010.
10.1211/0022357001775010
- Rocha, M.J.; Almeida, A.M.; Afonso, E.; Martins, V.; Santos, J.; Leitão, F.; Falcão, A.C.. "The kinetic profile of gentamicin
in premature neonates". Journal of Pharmacy and Pharmacology 52 9 (2000): 1091-1097. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033802504&partnerID=MN8TOARS.
- Amílcar Falcão. "Theophylline pharmacokinetics with concomitant steroid and gold therapy". Journal of clinical pharmacy
and therapeutics (2000): https://doi.org/10.1046/j.1365-2710.2000.00279.x.
10.1046/j.1365-2710.2000.00279.x
- Almeida, A.M.; Falcao, A.C.. "PKBase: A population approach-oriented database [4]". Annals of Pharmacotherapy 34 1
(2000): 123-124. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033966812&partnerID=MN8TOARS.
- Costa, I.M.; Soares, P.J.; Afonso, M.; Ratado, P.; Lanao, J.M.; Falcão, A.C.. "Therapeutic monitoring of warfarin: The appropriate
response marker". Journal of Pharmacy and Pharmacology 52 11 (2000): 1405-1410. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033658388&partnerID=MN8TOARS.
- Amílcar Falcão. "PKBase: a population approach-oriented database". The Annals of pharmacotherapy (2000): https://doi.org/10.1345/aph.19160.
10.1345/aph.19160
- Amílcar Falcão. "Predictive capacity of carbamazepine pharmacokinetic parameters in a Portuguese outpatient population". Therapeutic
drug monitoring (1999): https://doi.org/10.1097/00007691-199904000-00014.
10.1097/00007691-199904000-00014
- Silva, R.; Reis, E.; Bispo, M.A.; Almeida, A.M.; Costa, I.M.; Falcão, F.; Palminha, J.M.; Falcão, A.C.. "The kinetic profile
of vancomycin in neonates". Journal of Pharmacy and Pharmacology 50 11 (1998): 1255-1260. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031762993&partnerID=MN8TOARS.
- Amílcar Falcão. "Kinetic profile of carbamazepine in an adult Portuguese outpatient population". Journal of clinical pharmacy
and therapeutics (1998): https://doi.org/10.1046/j.1365-2710.1998.00166.x.
10.1046/j.1365-2710.1998.00166.x
- Amílcar Falcão. "The kinetic profile of vancomycin in neonates". The Journal of pharmacy and pharmacology (1998): https://doi.org/10.1111/j.2042-7158.1998.tb03342.x.
10.1111/j.2042-7158.1998.tb03342.x
- Amílcar Falcão. "Carbamazepine population pharmacokinetics in children: mixed-effect models". Therapeutic drug monitoring
(1997): https://doi.org/10.1097/00007691-199704000-00003.
10.1097/00007691-199704000-00003
- Amílcar Falcão. "Population pharmacokinetics of caffeine in premature neonates". European journal of clinical pharmacology
(1997): https://doi.org/10.1007/s002280050276.
10.1007/s002280050276
- Falcão AC; Caramona M. "Therapeutic monitoring of theophylline--a real need!". (1992): http://europepmc.org/abstract/med/1421662.
- Amílcar Falcão. "Therapeutic monitoring of theophylline--a real need!". The Annals of pharmacotherapy (1992): https://doi.org/10.1177/106002809202601025.
10.1177/106002809202601025
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