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Identificação

Identificação pessoal

Nome completo
Alessandro Prigione

Identificadores de autor

Ciência ID
D11D-C356-1CE5
ORCID iD
0000-0001-9457-1952
Formação
Grau Classificação
2004/03/01 - 2008/02/28
Concluído
PhD in Molecular Medicine (Postgraduate Certificate)
Especialização em Section Neuroscience
Università Vita Salute San Raffaele, Itália
"Pathogenetic pathways of Parkinson’s disease: the role of oxidative stress, autophagy, and mitochondrial DNA deletions" (TESE/DISSERTAÇÃO)
1996/09/01 - 2002/07/20
Concluído
Medicine (Bachelor)
Università degli Studi di Milano Facoltà di Medicina e Chirurgia, Itália
"The retrograde memory: standardization of a new test for media-mediated events" (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2019/08/01 - Atual Investigador principal (carreira) (Investigação) Heinrich-Heine-Universität Düsseldorf Medizinische Fakultät, Alemanha
Projetos

Bolsa

Designação Financiadores
2023/06/01 - 2028/05/31 Accelerating drug repurposing for rare neurological, neurometabolic and neuromuscular disorders by exploiting SIMilarities in clinical and molecular PATHology
101080249
Investigador responsável
2022/03/01 - 2025/02/28 Mitochondrial remodeling in human neurons, astrocytes, and brain organoids under metabolic failure
PR1527/6-1
Co-Investigador Responsável (Co-IR)
Em curso
2021/06/01 - 2024/12/31 CureMILS: A reprogramming-based strategy for drug repositioning in patients with mitochondrial DNA-associated Leigh syndrome
01GM2002A
Investigador responsável
Em curso
Produções

Publicações

Artigo em revista
  1. Stephanie Le; Carmen Menacho; Alessandro Prigione. "Balancing neuronal activity to fight neurodevelopmental disorders". Trends in Neurosciences (2024): https://doi.org/10.1016/j.tins.2024.03.002.
    10.1016/j.tins.2024.03.002
  2. Isabella Tolle; Valeria Tiranti; Alessandro Prigione. "Modeling mitochondrial DNA diseases: from base editing to pluripotent stem-cell-derived organoids". EMBO reports (2023): https://doi.org/10.15252/embr.202255678.
    10.15252/embr.202255678
  3. Alessandro Prigione; Carlo Viscomi. "How to mitigate neurological and cardiac decompensation in Leigh syndrome: Can nicotinamide riboside be an answer?". Clinical and Translational Discovery (2022): https://doi.org/10.1002/ctd2.124.
    10.1002/ctd2.124
  4. Dario Brunetti; Werner Dykstra; Stephanie Le; Annika Zink; Alessandro Prigione. "Mitochondria in Neurogenesis: Implications for Mitochondrial Diseases". Stem Cells 39 10 (2021): 1289-1297. https://doi.org/10.1002/stem.3425.
    10.1002/stem.3425
  5. Prigione, A.. "Stem cell research moving forward". Stem Cell Research 55 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85113262627&partnerID=MN8TOARS.
    10.1016/j.scr.2021.102503
  6. Le, S.; Petersilie, L.; Inak, G.; Menacho-Pando, C.; Kafitz, K.W.; Rybak-Wolf, A.; Rajewsky, N.; Rose, C.R.; Prigione, A.. "Generation of human brain organoids for mitochondrial disease modeling". Journal of Visualized Experiments 2021 172 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85110822384&partnerID=MN8TOARS.
    10.3791/62756
  7. Zink, A.; Lisowski, P.; Prigione, A.. "Generation of human iPSC-derived neural progenitor cells (NPCs) as drug discovery model for neurological and mitochondrial disorders". Bio-protocol 11 5 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85116289031&partnerID=MN8TOARS.
    10.21769/BioProtoc.3939
  8. Palombo, F.; Peron, C.; Caporali, L.; Iannielli, A.; Maresca, A.; Di Meo, I.; Fiorini, C.; et al. "The relevance of mitochondrial DNA variants fluctuation during reprogramming and neuronal differentiation of human iPSCs". Stem Cell Reports 16 8 (2021): 1953-1967. http://www.scopus.com/inward/record.url?eid=2-s2.0-85111992064&partnerID=MN8TOARS.
    10.1016/j.stemcr.2021.06.016
  9. Göttle, P.; Schichel, K.; Reiche, L.; Werner, L.; Zink, A.; Prigione, A.; Küry, P.. "TLR4 Associated Signaling Disrupters as a New Means to Overcome HERV-W Envelope-Mediated Myelination Deficits". Frontiers in Cellular Neuroscience 15 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85120877625&partnerID=MN8TOARS.
    10.3389/fncel.2021.777542
  10. Ravindran, E.; De Velazco, C.G.; Ghazanfar, A.; Kraemer, N.; Waheed, A.; Hanif, M.; Mughal, S.; et al. "Homozygous mutation in MCM7 causes autosomal recessive primary microcephaly and intellectual disability". Journal of Medical Genetics (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85107286315&partnerID=MN8TOARS.
    10.1136/jmedgenet-2020-107518
  11. Inak, G.; Rybak-Wolf, A.; Lisowski, P.; Pentimalli, T.M.; Jüttner, R.; Glažar, P.; Uppal, K.; et al. "Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome". Nature Communications 12 1 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85103394405&partnerID=MN8TOARS.
    10.1038/s41467-021-22117-z
  12. Scior, A.; Arnsburg, K.; Iburg, M.; Juenemann, K.; Lucia Pigazzini, M.; Mlody, B.; Puchkov, D.; et al. "Corrigendum to: Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex (The EMBO Journal, (2018), 37, 2, (282-299), 10.15252/embj.201797212)". EMBO Journal 40 19 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85116103567&partnerID=MN8TOARS.
    10.15252/embj.2021109413
  13. Stephen C. Cunnane; Eugenia Trushina; Cecilie Morland; Alessandro Prigione; Gemma Casadesus; Zane B. Andrews; M. Flint Beal; et al. "Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing". Nature Reviews Drug Discovery 19 9 (2020): 609-633. https://doi.org/10.1038/s41573-020-0072-x.
    10.1038/s41573-020-0072-x
  14. Akrivi Asimakopoulou; Ioannis Gkekas; Georgia Kastrinaki; Alessandro Prigione; Vasileios T. Zaspalis; Spyros Petrakis. "Biocompatibility of a-Al2O3 Ceramic Substrates with Human Neural Precursor Cells". Journal of Functional Biomaterials (2020): https://doi.org/10.3390/jfb11030065.
    10.3390/jfb11030065
  15. Carmen Menacho; Alessandro Prigione. "Tackling mitochondrial diversity in brain function: from animal models to human brain organoids". The International Journal of Biochemistry & Cell Biology 123 (2020): 105760-105760. https://doi.org/10.1016/j.biocel.2020.105760.
    10.1016/j.biocel.2020.105760
  16. Delgado-Benito, V.; Berruezo-Llacuna, M.; Altwasser, R.; Winkler, W.; Sundaravinayagam, D.; Balasubramanian, S.; Caganova, M.; et al. "PDGFA-associated protein 1 protects mature B lymphocytes from stress-induced cell death and promotes antibody gene diversification". Journal of Experimental Medicine 217 10 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85087532009&partnerID=MN8TOARS.
    10.1084/JEM.20200137
  17. Bottani, E.; Lamperti, C.; Prigione, A.; Tiranti, V.; Persico, N.; Brunetti, D.. "Therapeutic approaches to treat mitochondrial diseases: “One-size-fits-all” and “precision medicine” strategies". Pharmaceutics 12 11 (2020): 1-63. http://www.scopus.com/inward/record.url?eid=2-s2.0-85096017834&partnerID=MN8TOARS.
    10.3390/pharmaceutics12111083
  18. Zink, A.; Conrad, J.; Telugu, N.S.; Diecke, S.; Heinz, A.; Wanker, E.; Priller, J.; Prigione, A.. "Assessment of Ethanol-Induced Toxicity on iPSC-Derived Human Neurons Using a Novel High-Throughput Mitochondrial Neuronal Health (MNH) Assay". Frontiers in Cell and Developmental Biology 8 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85096228853&partnerID=MN8TOARS.
    10.3389/fcell.2020.590540
  19. Laidou, S.; Alanis-Lobato, G.; Pribyl, J.; Raskó, T.; Tichy, B.; Mikulasek, K.; Tsagiopoulou, M.; et al. "Nuclear inclusions of pathogenic ataxin-1 induce oxidative stress and perturb the protein synthesis machinery". Redox Biology 32 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85080931281&partnerID=MN8TOARS.
    10.1016/j.redox.2020.101458
  20. Malgorzata Rydzanicz; Malgorzata Wachowska; Erik C. Cook; Pawel Lisowski; Bozena Kuzniewska; Krystyna Szymanska; Sebastian Diecke; et al. "Novel calcineurin A (PPP3CA) variant associated with epilepsy, constitutive enzyme activation and downregulation of protein expression". European Journal of Human Genetics 27 1 (2019): 61-69. https://doi.org/10.1038/s41431-018-0254-8.
    10.1038/s41431-018-0254-8
  21. Wang, J.; Singh, M.; Sun, C.; Besser, D.; Prigione, A.; Ivics, Z.; Hurst, L.D.; Izsvák, Z.. "Author Correction: Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression (Nature Protocols, (2016), 11, 2, (327-346), 10.1038/nprot.2016.016)". Nature Protocols 14 8 (2019): 2596-2596. http://www.scopus.com/inward/record.url?eid=2-s2.0-85055700402&partnerID=MN8TOARS.
    10.1038/s41596-018-0086-6
  22. Iannetti, E.F.; Prigione, A.; Smeitink, J.A.M.; Koopman, W.J.H.; Beyrath, J.; Renkema, H.. "Live-imaging readouts and cell models for phenotypic profiling of mitochondrial function". Frontiers in Genetics 10 MAR (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85066612022&partnerID=MN8TOARS.
    10.3389/fgene.2019.00131
  23. Pawel Lisowski; Preethi Kannan; Barbara Mlody; Alessandro Prigione. "Mitochondria and the dynamic control of stem cell homeostasis". EMBO reports 19 5 (2018): https://doi.org/10.15252/embr.201745432.
    10.15252/embr.201745432
  24. Jadasz, J.J.; Tepe, L.; Beyer, F.; Samper Agrelo, I.; Akkermann, R.; Spitzhorn, L.-S.; Silva, M.E.; et al. "Human mesenchymal factors induce rat hippocampal- and human neural stem cell dependent oligodendrogenesis". GLIA 66 1 (2018): 145-160. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030175741&partnerID=MN8TOARS.
    10.1002/glia.23233
  25. Zink, A.; Priller, J.; Prigione, A.. "Pluripotent Stem Cells for Uncovering the Role of Mitochondria in Human Brain Function and Dysfunction". Journal of Molecular Biology 430 7 (2018): 891-903. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042606177&partnerID=MN8TOARS.
    10.1016/j.jmb.2018.02.005
  26. Scior, A.; Buntru, A.; Arnsburg, K.; Ast, A.; Iburg, M.; Juenemann, K.; Pigazzini, M.L.; et al. "Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex". EMBO Journal 37 2 (2018): 282-299. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040768856&partnerID=MN8TOARS.
    10.15252/embj.201797212
  27. Gizem Inak; Carmen Lorenz; Pawel Lisowski; Annika Zink; Barbara Mlody; Alessandro Prigione. "Concise Review: Induced Pluripotent Stem Cell-Based Drug Discovery for Mitochondrial Disease". STEM CELLS 35 7 (2017): 1655-1662. https://doi.org/10.1002/stem.2637.
    10.1002/stem.2637
  28. Lorenz, C.; Lesimple, P.; Bukowiecki, R.; Zink, A.; Inak, G.; Mlody, B.; Singh, M.; et al. "Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders". Cell Stem Cell 20 5 (2017): 659-674.e9. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010918121&partnerID=MN8TOARS.
    10.1016/j.stem.2016.12.013
  29. Lorenz, C.; Prigione, A.. "Mitochondrial metabolism in early neural fate and its relevance for neuronal disease modeling". Current Opinion in Cell Biology 49 (2017): 71-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-85038848844&partnerID=MN8TOARS.
    10.1016/j.ceb.2017.12.004
  30. Mlody, B.; Prigione, A.. "A Glycolytic Solution for Pluripotent Stem Cells". Cell Stem Cell 19 4 (2016): 419-420. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992379141&partnerID=MN8TOARS.
    10.1016/j.stem.2016.09.005
  31. Prigione, A.. "A mitochondrial view of cell fate". Seminars in Cell and Developmental Biology 52 (2016): 66-67. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961242005&partnerID=MN8TOARS.
    10.1016/j.semcdb.2016.03.008
  32. Lorenz, C.; Prigione, A.. "Aging vs. rejuvenation: Reprogramming to iPSCs does not turn back the clock for somatic mitochondrial DNA mutations". Stem Cell Investigation 2016 SEP (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84995467626&partnerID=MN8TOARS.
    10.21037/sci.2016.08.09
  33. Wang, J.; Singh, M.; Sun, C.; Besser, D.; Prigione, A.; Ivics, Z.; Hurst, L.D.; Izsvák, Z.. "Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression". Nature Protocols 11 2 (2016): 327-346. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956513843&partnerID=MN8TOARS.
    10.1038/nprot.2016.016
  34. Rohwer, N.; Bindel, F.; Grimm, C.; Lin, S.J.; Wappler, J.; Klinger, B.; Blüthgen, N.; et al. "Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A". Oncotarget 7 6 (2016): 6693-6710. http://www.scopus.com/inward/record.url?eid=2-s2.0-84981223986&partnerID=MN8TOARS.
    10.18632/oncotarget.6793
  35. Schottmann, G.; Sarpong, A.; Lorenz, C.; Weinhold, N.; Gill, E.; Teschner, L.; Ferdinandusse, S.; et al. "A movement disorder with dystonia and ataxia caused by a mutation in the HIBCH gene". Movement Disorders 31 11 (2016): 1733-1739. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979270645&partnerID=MN8TOARS.
    10.1002/mds.26704
  36. Mlody, B.; Lorenz, C.; Inak, G.; Prigione, A.. "Energy metabolism in neuronal/glial induction and in iPSC models of brain disorders". Seminars in Cell and Developmental Biology 52 (2016): 102-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961197513&partnerID=MN8TOARS.
    10.1016/j.semcdb.2016.02.018
  37. Bukowiecki, Raul; Lesimple, Pierre; Lorenz, Carmen; Leong, Megan; Singh, Manvendra; Auré, Karine; Semtner, Marcus; et al. "iPSC-derived neural progenitors carrying a MT-ATP6 mutation exhibit mitochondrial hyperpolarization and calcium-related defects". Mitochondrion 24 (2015): S28-S29. http://dx.doi.org/10.1016/j.mito.2015.07.082.
    10.1016/j.mito.2015.07.082
  38. Stincone, A.; Prigione, A.; Cramer, T.; Wamelink, M.M.C.; Campbell, K.; Cheung, E.; Olin-Sandoval, V.; et al. "The return of metabolism: Biochemistry and physiology of the pentose phosphate pathway". Biological Reviews 90 3 (2015): 927-963. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937115913&partnerID=MN8TOARS.
    10.1111/brv.12140
  39. Prigione, A.; Ruiz-Pérez, M.V.; Bukowiecki, R.; Adjaye, J.. "Metabolic restructuring and cell fate conversion". Cellular and Molecular Life Sciences 72 9 (2015): 1759-1777. http://www.scopus.com/inward/record.url?eid=2-s2.0-84931331009&partnerID=MN8TOARS.
    10.1007/s00018-015-1834-1
  40. Hossini, A.M.; Megges, M.; Prigione, A.; Lichtner, B.; Toliat, M.R.; Wruck, W.; Schröter, F.; et al. "Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks". BMC Genomics 16 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84924303131&partnerID=MN8TOARS.
    10.1186/s12864-015-1262-5
  41. Hossini, A.M.; Megges, M.; Prigione, A.; Lichtner, B.; Toliat, M.R.; Wruck, W.; Schröter, F.; et al. "Erratum: Induced pluripotent stem cell-derived neuronal cells from a sporadic Alzheimer's disease donor as a model for investigating AD-associated gene regulatory networks [BMC Genomics (2015), 16:84] doi:10.1186/s12864-015-1262-5.". BMC Genomics 16 1 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84938962343&partnerID=MN8TOARS.
    10.1186/s12864-015-1537-x
  42. Bukowiecki, R.; Adjaye, J.; Prigione, A.. "Mitochondrial function in pluripotent stem cells and cellular reprogramming". Gerontology 60 2 (2014): 174-182. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896306292&partnerID=MN8TOARS.
    10.1159/000355050
  43. Prigione, A.; Adjaye, J.. "A mitochondrial strategy for safeguarding the reprogrammed genome". Cell Regeneration 3 1 (2014): 3:5-3:5. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988239965&partnerID=MN8TOARS.
    10.1186/2045-9769-3-5
  44. Prigione, A.; Rohwer, N.; Hoffmann, S.; Mlody, B.; Drews, K.; Bukowiecki, R.; Blümlein, K.; et al. "HIF1a modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2". Stem Cells 32 2 (2014): 364-376. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894554252&partnerID=MN8TOARS.
    10.1002/stem.1552
  45. Wang, J.; Xie, G.; Singh, M.; Ghanbarian, A.T.; Raskó, T.; Szvetnik, A.; Cai, H.; et al. "Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells". Nature 516 7531 (2014): 405-409. http://www.scopus.com/inward/record.url?eid=2-s2.0-84922115236&partnerID=MN8TOARS.
    10.1038/nature13804
  46. Al-Nbaheen, M.; vishnubalaji, R.; Ali, D.; Bouslimi, A.; Al-Jassir, F.; Megges, M.; Prigione, A.; et al. "Human Stromal (Mesenchymal) Stem Cells from Bone Marrow, Adipose Tissue and Skin Exhibit Differences in Molecular Phenotype and Differentiation Potential". Stem Cell Reviews and Reports 9 1 (2013): 32-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873730138&partnerID=MN8TOARS.
    10.1007/s12015-012-9365-8
  47. Vigone, G.; Merico, V.; Prigione, A.; Mulas, F.; Sacchi, L.; Gabetta, M.; Bellazzi, R.; et al. "Transcriptome based identification of mouse cumulus cell markers that predict the developmental competence of their enclosed antral oocytes". BMC Genomics 14 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84878646134&partnerID=MN8TOARS.
    10.1186/1471-2164-14-380
  48. Stachelscheid, H.; Wulf-Goldenberg, A.; Eckert, K.; Jensen, J.; Edsbagge, J.; Björquist, P.; Rivero, M.; et al. "Teratoma formation of human embryonic stem cells in three-dimensional perfusion culture bioreactors". Journal of Tissue Engineering and Regenerative Medicine 7 9 (2013): 729-741. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882249931&partnerID=MN8TOARS.
    10.1002/term.1467
  49. Zuccotti, M.; Merico, V.; Belli, M.; Mulas, F.; Sacchi, L.; Zupan, B.; Redi, C.A.; et al. "OCT4 and the acquisition of oocyte developmental competence during folliculogenesis". International Journal of Developmental Biology 56 10-12 (2012): 853-858. http://www.scopus.com/inward/record.url?eid=2-s2.0-84873722986&partnerID=MN8TOARS.
    10.1387/ijdb.120174mz
  50. Drews, K.; Jozefczuk, J.; Prigione, A.; Adjaye, J.. "Human induced pluripotent stem cells-from mechanisms to clinical applications". Journal of Molecular Medicine 90 7 (2012): 735-745. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865142720&partnerID=MN8TOARS.
    10.1007/s00109-012-0913-0
  51. Prigione, A.; Lichtner, B.; Kuhl, H.; Struys, E.A.; Wamelink, M.; Lehrach, H.; Ralser, M.; Timmermann, B.; Adjaye, J.. "Human induced pluripotent stem cells harbor homoplasmic and heteroplasmic mitochondrial DNA mutations while maintaining human embryonic stem cell-like metabolic reprogramming". Stem Cells 29 9 (2011): 1338-1348. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052015415&partnerID=MN8TOARS.
    10.1002/stem.683
  52. Mah, N.; Wang, Y.; Liao, M.-C.; Prigione, A.; Jozefczuk, J.; Lichtner, B.; Wolfrum, K.; et al. "Molecular insights into reprogramming-initiation events mediated by the OSKM gene regulatory network". PLoS ONE 6 8 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80052314331&partnerID=MN8TOARS.
    10.1371/journal.pone.0024351
  53. Zuccotti, M.; Merico, V.; Bellone, M.; Mulas, F.; Sacchi, L.; Rebuzzini, P.; Prigione, A.; et al. "Gatekeeper of pluripotency: A common Oct4 transcriptional network operates in mouse eggs and embryonic stem cells". BMC Genomics 12 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79959837836&partnerID=MN8TOARS.
    10.1186/1471-2164-12-345
  54. Prigione, A.; Adjaye, J.. "Modulation of mitochondrial biogenesis and bioenergetic metabolism upon in vitro and in vivo differentiation of human ES and iPS cells". International Journal of Developmental Biology 54 11-12 (2011): 1729-1741. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960012954&partnerID=MN8TOARS.
    10.1387/ijdb.103198ap
  55. Krüger, R.; Sharma, M.; Riess, O.; Gasser, T.; Van Broeckhoven, C.; Theuns, J.; Aasly, J.; et al. "A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease". Neurobiology of Aging 32 3 (2011): 548.e9-548.e18. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952900158&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2009.11.021
  56. Prigione, A.; Hossini, A.M.; Lichtner, B.; Serin, A.; Fauler, B.; Megges, M.; Lurz, R.; et al. "Mitochondrial-Associated cell death mechanisms are reset to an Embryonic-Like state in aged Donor-Derived iPS cells harboring chromosomal aberrations". PLoS ONE 6 11 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-81055124788&partnerID=MN8TOARS.
    10.1371/journal.pone.0027352
  57. Jozefczuk, J.; Prigione, A.; Chavez, L.; Adjaye, J.. "Comparative analysis of human embryonic stem cell and induced pluripotent stem cell-derived hepatocyte-like cells reveals current drawbacks and possible strategies for improved differentiation". Stem Cells and Development 20 7 (2011): 1259-1275. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959820846&partnerID=MN8TOARS.
    10.1089/scd.2010.0361
  58. Prigione, A.; Fauler, B.; Lurz, R.; Lehrach, H.; Adjaye, J.. "The senescence-related mitochondrial/oxidative stress pathway is repressed in human induced pluripotent stem cells". Stem Cells 28 4 (2010): 721-733. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951002352&partnerID=MN8TOARS.
    10.1002/stem.404
  59. Wang, Y.; Mah, N.; Prigione, A.; Wolfrum, K.; Andrade-Navarro, M.A.; Adjaye, J.. "A transcriptional roadmap to the induction of pluripotency in somatic cells". Stem Cell Reviews and Reports 6 2 (2010): 282-296. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953916259&partnerID=MN8TOARS.
    10.1007/s12015-010-9137-2
  60. Prigione, A.; Piazza, F.; Brighina, L.; Begni, B.; Galbussera, A.; DiFrancesco, J.C.; Andreoni, S.; Piolti, R.; Ferrarese, C.. "Alpha-synuclein nitration and autophagy response are induced in peripheral blood cells from patients with Parkinson disease". Neuroscience Letters 477 1 (2010): 6-10. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952959227&partnerID=MN8TOARS.
    10.1016/j.neulet.2010.04.022
  61. Wolfrum, K.; Wang, Y.; Prigione, A.; Sperling, K.; Lehrach, H.; Adjaye, J.. "The LARGE principle of cellular reprogramming: Lost, acquired and retained gene expression in foreskin and amniotic fluid-derived human iPS cells". PLoS ONE 5 10 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-78149442366&partnerID=MN8TOARS.
    10.1371/journal.pone.0013703
  62. Di Stefano, B.; Buecker, C.; Ungaro, F.; Prigione, A.; Chen, H.-H.; Welling, M.; Eijpe, M.; et al. "An ES-Like pluripotent state in FGF-dependent murine iPS cells". PLoS ONE 5 12 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-78651245304&partnerID=MN8TOARS.
    10.1371/journal.pone.0016092
  63. Brighina, L.; Prigione, A.; Begni, B.; Galbussera, A.; Andreoni, S.; Piolti, R.; Ferrarese, C.. "Lymphomonocyte alpha-synuclein levels in aging and in Parkinson disease". Neurobiology of Aging 31 5 (2010): 884-885. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950535153&partnerID=MN8TOARS.
    10.1016/j.neurobiolaging.2008.06.010
  64. Prigione, A.; Isaias, I.U.; Galbussera, A.; Brighina, L.; Begni, B.; Andreoni, S.; Pezzoli, G.; Antonini, A.; Ferrarese, C.. "Increased oxidative stress in lymphocytes from untreated Parkinson's disease patients". Parkinsonism and Related Disorders 15 4 (2009): 327-328. http://www.scopus.com/inward/record.url?eid=2-s2.0-64249125448&partnerID=MN8TOARS.
    10.1016/j.parkreldis.2008.05.013
  65. Di Stefano, B.; Prigione, A.; Broccoli, V.. "Efficient genetic reprogramming of unmodified somatic neural progenitors uncovers the essential requirement of Oct4 and Klf4". Stem Cells and Development 18 5 (2009): 707-715. http://www.scopus.com/inward/record.url?eid=2-s2.0-66249092408&partnerID=MN8TOARS.
    10.1089/scd.2008.0180
  66. Alemi, M.; Prigione, A.; Wong, A.; Schoenfeld, R.; DiMauro, S.; Hirano, M.; Taroni, F.; Cortopassi, G.. "Mitochondrial DNA deletions inhibit proteasomal activity and stimulate an autophagic transcript". Free Radical Biology and Medicine 42 1 (2007): 32-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751531893&partnerID=MN8TOARS.
    10.1016/j.freeradbiomed.2006.09.014
  67. Prigione, A.; Cortopassi, G.. "Mitochondrial DNA deletions and chloramphenicol treatment stimulate the autophagic transcript ATG12". Autophagy 3 4 (2007): 377-380. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250841750&partnerID=MN8TOARS.
    10.4161/auto.4239
  68. Prigione, A.; Cortopassi, G.. "Mitochondrial DNA deletions induce the adenosine monophosphate-activated protein kinase energy stress pathway and result in decreased secretion of some proteins". Aging Cell 6 5 (2007): 619-630. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548627144&partnerID=MN8TOARS.
    10.1111/j.1474-9726.2007.00323.x
  69. Prigione, A.; Begni, B.; Galbussera, A.; Beretta, S.; Brighina, L.; Garofalo, R.; Andreoni, S.; Piolti, R.; Ferrarese, C.. "Oxidative stress in peripheral blood mononuclear cells from patients with Parkinson's disease: Negative correlation with levodopa dosage". Neurobiology of Disease 23 1 (2006): 36-43. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745120510&partnerID=MN8TOARS.
    10.1016/j.nbd.2006.01.013
  70. Bizzozero, I.; Lucchelli, F.; Prigione, A.; Saetti, M.C.; Spinnler, H.. ""What do you remember about Chernobyl?" A new test of memory for media-mediated events". Neurological Sciences 25 4 (2004): 205-215. http://www.scopus.com/inward/record.url?eid=2-s2.0-8444249602&partnerID=MN8TOARS.
    10.1007/s10072-004-0323-3
  71. Chiapponi, R.; Prigione, A.; Bailo, G.; Piacentino, A.. "Omphalocele and labor,Onfalocele e modalità del parto.". Minerva Ginecologica 40 11 (1988): 667-670. http://www.scopus.com/inward/record.url?eid=2-s2.0-0024118151&partnerID=MN8TOARS.
Capítulo de livro
  1. Inak, G.; Henke, M.-T.; Prigione, A.. "Bioenergetic Profiling of Human Pluripotent Stem Cells". 391-403. 2021.
    10.1007/978-1-0716-1270-5_24
  2. Prigione, A.; Cortopassi, G.; Ferrarese, C.. "Genomics of Brain Aging: Nuclear and Mitochondrial Genomes". 695-701. 2009.
Livro
  1. Pfiffer, V.; Prigione, A.. Assessing the bioenergetic profile of human pluripotent stem cells. 2015.
    10.1007/978-1-4939-2257-4_25
  2. Prigione, A.. Induced pluripotent stem cells (iPSCs) for modeling mitochondrial DNA disorders. 2015.
    10.1007/978-1-4939-2288-8_24

Outros

Outra produção
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    10.1101/2021.05.19.444448
  2. Assessment of ethanol-induced toxicity on iPSC-derived human dopaminergic neurons using a novel high-throughput mitochondrial neuronal health (MNH) assay. 2020. Annika Zink; Josefin Conrad; Narasimha Swami Telugu; Sebastian Diecke; Andreas Heinz; Erich Wanker; Josef Priller; Alessandro Prigione. https://doi.org/10.1101/2020.08.12.237461.
    10.1101/2020.08.12.237461
  3. SURF1 mutations causative of Leigh syndrome impair human neurogenesis. 2019. Inak, G.; Rybak-Wolf, A.; Lisowski, P.; Jüttner, R.; Zink, A.; Mlody, B.; Glažar, P.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85095640296&partnerID=MN8TOARS.
    10.1101/551390
Atividades

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2016/01/01 - 2019/12/31 Modeling Leigh syndrome using patient-specific induced pluripotent stem cells
Orientador