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Bruno Silva-Santos is a Full Professor and Director of Immuno-Oncology at the Faculty of Medicine of the University of Lisbon, and Group Leader and Vice-Director of the Instituto de Medicina Molecular (iMM) in Lisbon, Portugal. He got his PhD in Immunology from University College London in 2002 for work developed at Cancer Research UK (The London Research Institute), and then trained as a post-doc at King’s College London, before establishing his own group at iMM in 2006. His research, which has been funded, among others, by the European Research Council (ERC) and the la Caixa Foundation, is mostly dedicated to gamma-delta T cells, having dissected novel molecular mechanisms of their differentiation and tumor cell recognition, published in over 100 papers in top international peer-reviewed journals. In 2019, Bruno Silva-Santos was elected Member of European Molecular Organization (EMBO) in recognition of his scientific contributions. His translational work on Immuno-Oncology was further recognized with awards from Pfizer, AstraZeneca, Janssen and Bial; and the nomination as Honorary Member of the European Academy of Tumor Immunology. His patented work also constituted the basis for a start-up company focused on cancer immunotherapy, Lymphact, whose proprietary technology has been acquired by Takeda Pharmaceutical and is currently under clinical testing in 3 centers the USA (NCT05886491).
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Identificação

Identificação pessoal

Nome completo
Bruno Miguel de Carvalho Silva Santos

Nomes de citação

  • SILVA-SANTOS, Bruno

Identificadores de autor

Ciência ID
D51E-6517-BE6A
ORCID iD
0000-0003-4141-9302

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia
  • Ciências Médicas e da Saúde - Medicina Básica - Imunologia

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B1)
Alemão Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Espanhol; Castelhano Utilizador independente (B1) Utilizador proficiente (C1) Utilizador elementar (A1) Utilizador independente (B1)
Italiano Utilizador independente (B1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador independente (B1)
Português Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Formação
Grau Classificação
2002
Concluído
 Immunology (Doctor of Philosophy)
University of London, Reino Unido
"T cell development and lineage commitment" (TESE/DISSERTAÇÃO)
 Excellent
1996/09/26
Concluído
 Bioquímica (Doutoramento)
Universidade de Lisboa Faculdade de Ciências, Portugal
 18.4/20
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2006/01/01 - Atual Investigador principal (carreira) (Investigação) Instituto de Medicina Molecular, Portugal
2002/10/01 - 2005/10/31 Pós-doutorado (Investigação) King's College London Division of Immunology Infection and Inflammatory Disease, Reino Unido
1998/10/01 - 2002/09/30 Investigador (Investigação) University College London Division of Infection and Immunity, Reino Unido

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/09/01 - Atual Professor Catedrático (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal
Universidade de Lisboa Faculdade de Medicina, Portugal
2013 - 2022 Professor Associado (Docente Universitário) Instituto de Medicina Molecular, Portugal
2005/03/15 - 2013/11/30 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Medicina, Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2013/12/01 - 2022/08/31 Associate Professor (with Habilitation) Universidade de Lisboa Faculdade de Medicina, Portugal
Projetos

Bolsa

Designação Financiadores
2014/01 - 2014/12 Deciphering the outside-in mechanisms of human γδ T cell differentiation
Provided by PTCRIS: 133192
133192
 Fundação para a Ciência e a Tecnologia, I.P.
2013/04 - 2014/03 Development of a novel adoptive cell therapy for leukemia: characterization and optimization of gamma-delta T lymphocytes for clinical application.
Provided by PTCRIS: 126020
126020
 Fundação para a Ciência e a Tecnologia, I.P.
2010/02 - 2013/11 Relevance of Cholesterol - rich diet on protection from experimental cerebral malaria
99724
Provided by PTCRIS: 99724
 Fundação para a Ciência e a Tecnologia, I.P.
2008/08 - 2011/07 Cellular and molecular mechanisms of action of carbon monoxide in protection from severe malaria
64125
Provided by PTCRIS: 64125
 Fundação para a Ciência e a Tecnologia, I.P.

Projeto

Designação Financiadores
2021/06/01 - 2024/05/31 Regulation of gamma-delta T cells in the tumor microenvironment and their manipulation towards immunotherapy of solid cancers
PTDC/MED-ONC/6829/2020
Investigador responsável
Instituto de Medicina Molecular, Portugal
Em curso
2019/09/16 - 2022/09/15 Next generation CAR-T cells for adoptive immunotherapy of acute myeloid leukemia
HR00069
Investigador responsável
Obra Social La Caixa
Em curso
2015/07/01 - 2020/12/31 MicroRNA-mediated regulation of the balance between effector and regulatory T cell subsets in vivo
ERC_CoG_646701
Investigador responsável
European Research Council
Em curso
2016/06/01 - 2018/05/31 Cancer immunotherapy based on the adoptive transfer of Delta1 T cells
PTDC/DTP-PIC/4931/2014
Investigador responsável
Fundação para a Ciência e a Tecnologia
Concluído
2013/04 - 2016/04 Animal models of human disease: refinement of strategies and implementation of new technologies
Provided by PTCRIS: 125967
125967
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2010/07/01 - 2015/06/30 Molecular mechanisms of differentiation of pro-inflammatory T cell subsets in vivo
StG_260352
Investigador responsável
European Research Council
Concluído
2014/01 - 2014/12 Quantitative analysis of clonal evolution and characterization of tumor escape variants in relapsing Acute Myeloid Leukemia
134681
Provided by PTCRIS: 134681
Investigador
Fundação para a Ciência e a Tecnologia, I.P.
2010/02 - 2012/01 Regulation of T cell differentiation and activation by CD27-CD70 receptor-ligand interactions in the thymus and in the periphery
Provided by PTCRIS: 104158
104158
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2007/01/01 - 2011/12/31 Innate mechanisms of tutor immune surveillance
IG_63
Investigador responsável
European Molecular Biology Laboratory
Concluído
2008/01 - 2010/12 Identification of ligands for γδ T cell receptors: a genomics/ transcriptomics approach.
71663
Provided by PTCRIS: 71663
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
2007/07 - 2010/01 Molecular mechanisms of tumor antigen recognition and cellular activation of γδ T lymphocytes.
71662
Provided by PTCRIS: 71662
Investigador responsável
Fundação para a Ciência e a Tecnologia, I.P.
Produções

Publicações

Artigo em revista
  1. Gonçalo Palrão Costa; Sofia Mensurado; Bruno Silva-Santos. "Therapeutic avenues for ¿d T cells in cancer". Journal for ImmunoTherapy of Cancer (2023): https://doi.org/10.1136/jitc-2023-007955.
    10.1136/jitc-2023-007955
  2. Bruno Silva-Santos; Julie C. Ribot; Erin J. Adams; Benjamin E. Willcox; Matthias Eberl. "¿d T cell explorations seek terra firma". Nature Immunology (2023): https://doi.org/10.1038/s41590-023-01606-x.
    10.1038/s41590-023-01606-x
  3. Sofia Mensurado; Rafael Blanco-Domínguez; Bruno Silva-Santos. "The emerging roles of ¿d T cells in cancer immunotherapy". Nature Reviews Clinical Oncology (2023): https://doi.org/10.1038/s41571-022-00722-1.
    10.1038/s41571-022-00722-1
  4. Bruno Silva-Santos; Sofia Mensurado. "¿d T cells maintain sensitivity to immunotherapy in MHC-I-deficient tumors". Nature Immunology (2023): https://doi.org/10.1038/s41590-023-01429-w.
    10.1038/s41590-023-01429-w
  5. Chora, Ângelo Ferreira; Marques, Sofia; Gonçalves, Joana Lisboa; Lima, Priscila; Gomes da Costa, Daniel; Fernandez-Ruiz, Daniel; Marreiros, Maria Inês; et al. "Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via ¿d T cells and IL-17-promoted stress erythropoiesis". Immunity 56 3 (2023): 592-605.e8. http://dx.doi.org/10.1016/j.immuni.2023.01.031.
    10.1016/j.immuni.2023.01.031
  6. Papotto, Pedro H.; Yilmaz, Bahtiyar; Pimenta, Gonçalo; Mensurado, Sofia; Cunha, Carolina; Fiala, Gina J.; Gomes da Costa, Daniel; et al. "Maternal ¿d T cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner". Cell Reports 42 2 (2023): 112074. http://dx.doi.org/10.1016/j.celrep.2023.112074.
    10.1016/j.celrep.2023.112074
  7. Sofia Mensurado; Bruno Silva-Santos. "Battle of the ¿d T cell subsets in the gut". Trends in Cancer (2022): https://doi.org/10.1016/j.trecan.2022.08.006.
    10.1016/j.trecan.2022.08.006
  8. Sánchez Martínez, Diego; Tirado, Néstor; Mensurado, Sofia; Martínez-Moreno, Alba; Romecín, Paola; Gutiérrez Agüera, Francisco; Correia, Daniel V; Silva-Santos, Bruno; Menéndez, Pablo. "Generation and proof-of-concept for allogeneic CD123 CAR-Delta One T (DOT) cells in acute myeloid leukemia". Journal for ImmunoTherapy of Cancer 10 9 (2022): e005400. http://dx.doi.org/10.1136/jitc-2022-005400.
    10.1136/jitc-2022-005400
  9. Gisela Gordino; Sara Costa-Pereira; Patrícia Corredeira; Patrícia Alves; Luís Costa; Anita Q Gomes; Bruno Silva-Santos; Julie C Ribot. "MicroRNA-181a restricts human ¿d T cell differentiation by targeting Map3k2 and Notch2". EMBO reports (2022): https://doi.org/10.15252/embr.202052234.
    10.15252/embr.202052234
  10. Oh, David Y.; Fong, Lawrence; Newell, Evan W.; Turk, Mary Jo; Chi, Hongbo; Chang, Howard Y.; Satpathy, Ansuman T.; et al. "Toward a better understanding of T cells in cancer". Cancer Cell 39 12 (2021): 1549-1552. http://dx.doi.org/10.1016/j.ccell.2021.11.010.
    10.1016/j.ccell.2021.11.010
  11. Pedro H. Papotto; Bahtiyar Yilmaz; Bruno Silva-Santos. "Crosstalk between ¿d T cells and the microbiota". Nature Microbiology (2021): https://doi.org/10.1038/s41564-021-00948-2.
    10.1038/s41564-021-00948-2
  12. Brigas, Helena C.; Ribeiro, Miguel; Coelho, Joana E.; Gomes, Rui; Gomez-Murcia, Victoria; Carvalho, Kevin; Faivre, Emilie; et al. "IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer’s disease". Cell Reports 36 9 (2021): 109574. http://dx.doi.org/10.1016/j.celrep.2021.109574.
    10.1016/j.celrep.2021.109574
  13. Ana Pamplona; Bruno Silva-Santos. "¿d T cells in malaria: a double-edged sword". The FEBS Journal (2021): https://doi.org/10.1111/febs.15494.
    10.1111/febs.15494
  14. Lopes, Noella; McIntyre, Claire; Martin, Stefania; Raverdeau, Mathilde; Sumaria, Nital; Kohlgruber, Ayano C.; Fiala, Gina J.; et al. "Distinct metabolic programs established in the thymus control effector functions of ¿d T cell subsets in tumor microenvironments". Nature Immunology 22 2 (2021): 179-192. http://dx.doi.org/10.1038/s41590-020-00848-3.
    10.1038/s41590-020-00848-3
  15. Lopes, Noëlla; Silva-Santos, Bruno. "Functional and metabolic dichotomy of murine ¿d T cell subsets in cancer immunity". European Journal of Immunology 51 1 (2020): 17-26. http://dx.doi.org/10.1002/eji.201948402.
    10.1002/eji.201948402
  16. Bonavita, Eduardo; Bromley, Christian P.; Jonsson, Gustav; Pelly, Victoria S.; Sahoo, Sudhakar; Walwyn-Brown, Katherine; Mensurado, Sofia; et al. "Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade". Immunity 53 6 (2020): 1215-1229.e8. http://dx.doi.org/10.1016/j.immuni.2020.10.020.
    10.1016/j.immuni.2020.10.020
  17. Gina J. Fiala; Anita Q. Gomes; Bruno Silva-Santos. "From thymus to periphery: Molecular basis of effector ¿d-T cell differentiation". Immunological Reviews (2020): https://doi.org/10.1111/imr.12918.
    10.1111/imr.12918
  18. Julie C. Ribot; Noëlla Lopes; Bruno Silva-Santos. "¿d T cells in tissue physiology and surveillance". Nature Reviews Immunology (2020): https://doi.org/10.1038/s41577-020-00452-4.
    10.1038/s41577-020-00452-4
  19. Santos, Bruno. "A population of proinflammatory T cells coexpresses aß and ¿d T cell receptors in mice and humans.". The Journal of Experimental Medicine (2020): https://doi.org/10.1084/jem.20190834.
    10.1084/jem.20190834
  20. Zsolt Sebestyen; Immo Prinz; Julie Déchanet-Merville; Bruno Silva-Santos; Jurgen Kuball. "Translating gammadelta (¿d) T cells and their receptors into cancer cell therapies". Nature Reviews Drug Discovery 19 3 (2020): 169-184. https://doi.org/10.1038/s41573-019-0038-z.
    10.1038/s41573-019-0038-z
  21. Santos, Bruno. "MicroRNA-181a regulates IFN-¿ expression in effector CD8+ T cell differentiation.". Journal of Molecular Medicine (2020): https://europepmc.org/articles/PMC7007887.
    10.1007/s00109-019-01865-y
  22. Santos, Bruno. "NKp46-expressing human gut-resident intraepithelial Vd1 T cell subpopulation exhibits high antitumor activity against colorectal cancer.". JCI insight (2019): https://europepmc.org/articles/PMC6975269.
    10.1172/jci.insight.125884
  23. Biagio Di Lorenzo; Sarina Ravens; Bruno Silva-Santos. "High-throughput analysis of the human thymic Vd1+ T cell receptor repertoire". Scientific Data (2019): https://doi.org/10.1038/s41597-019-0118-2.
    10.1038/s41597-019-0118-2
  24. Santos, Bruno. "Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection.". Nature communications (2019): https://europepmc.org/articles/PMC6825213.
    10.1038/s41467-019-12983-z
  25. Santos, Bruno. "Meningeal ¿d T cell-derived IL-17 controls synaptic plasticity and short-term memory.". Science immunology (2019): https://doi.org/10.1126/sciimmunol.aay5199.
    10.1126/sciimmunol.aay5199
  26. Bruno Silva-Santos; Sofia Mensurado; Seth B. Coffelt. "¿d T cells: pleiotropic immune effectors with therapeutic potential in cancer". Nature Reviews Cancer (2019): https://doi.org/10.1038/s41568-019-0153-5.
    10.1038/s41568-019-0153-5
  27. Santos, Bruno. "Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ V¿6+ T Cells to Skin Residency as Activated Effector Cells.". Cell reports (2019): https://doi.org/10.1016/j.celrep.2019.05.064.
    10.1016/j.celrep.2019.05.064
  28. Santos, Bruno. "¿d-T cells promote IFN-¿-dependent Plasmodium pathogenesis upon liver-stage infection.". PNAS - Proceedings of the National Academy of Sciences of the United States of America (2019): https://europepmc.org/articles/PMC6525508.
    10.1073/pnas.1814440116
  29. Santos, Bruno. "Broad Cytotoxic Targeting of Acute Myeloid Leukemia by Polyclonal Delta One T Cells.". Cancer immunology research (2019): https://doi.org/10.1158/2326-6066.CIR-18-0647.
    10.1158/2326-6066.cir-18-0647
  30. Santos, Bruno. "Tumor-associated neutrophils suppress pro-tumoral IL-17+ ¿d T cells through induction of oxidative stress.". PLoS Biology (2018): https://europepmc.org/articles/PMC5965901.
    10.1371/journal.pbio.2004990
  31. Santos, Bruno. "MicroRNA-146a controls functional plasticity in ¿d T cells by targeting NOD1.". Science immunology (2018): https://doi.org/10.1126/sciimmunol.aao1392.
    10.1126/sciimmunol.aao1392
  32. Santos, Bruno. "Got my ¿d17 T cells to keep me warm.". Nature immunology (2018): https://doi.org/10.1038/s41590-018-0090-6.
    10.1038/s41590-018-0090-6
  33. Santos, Bruno. "Molecular Determinants of Target Cell Recognition by Human ¿d T Cells.". Frontiers in Immunology (2018): https://europepmc.org/articles/PMC5934422.
    10.3389/fimmu.2018.00929
  34. Santos, Bruno. "Working in "NK Mode": Natural Killer Group 2 Member D and Natural Cytotoxicity Receptors in Stress-Surveillance by ¿d T Cells.". Frontiers in immunology (2018): https://europepmc.org/articles/PMC5928212.
    10.3389/fimmu.2018.00851
  35. Santos, Bruno. "The Emerging Complexity of ¿dT17 Cells.". Frontiers in Immunology (2018): https://europepmc.org/articles/PMC5919943.
    10.3389/fimmu.2018.00796
  36. Santos, Bruno. "Control of T cell effector functions by miRNAs.". Cancer letters (2018): https://doi.org/10.1016/j.canlet.2018.04.011.
    10.1016/j.canlet.2018.04.011
  37. Pedro H. Papotto; Annika Reinhardt; Immo Prinz; Bruno Silva-Santos. "Innately versatile: ¿d17 T cells in inflammatory and autoimmune diseases". Journal of Autoimmunity 87 (2018): 26-37. https://doi.org/10.1016/j.jaut.2017.11.006.
    10.1016/j.jaut.2017.11.006
  38. Santos, Bruno. "Low-Density Lipoprotein Uptake Inhibits the Activation and Antitumor Functions of Human V¿9Vd2 T Cells.". Cancer immunology research (2018): https://doi.org/10.1158/2326-6066.CIR-17-0327.
    10.1158/2326-6066.cir-17-0327
  39. Santos, Bruno. "VEGFR2-Mediated Reprogramming of Mitochondrial Metabolism Regulates the Sensitivity of Acute Myeloid Leukemia to Chemotherapy.". Cancer research (2017): https://doi.org/10.1158/0008-5472.CAN-17-1166.
    10.1158/0008-5472.can-17-1166
  40. Pedro H Papotto; Natacha Gonçalves-Sousa; Nina Schmolka; Andrea Iseppon; Sofia Mensurado; Brigitta Stockinger; Julie C Ribot; Bruno Silva-Santos. "IL -23 drives differentiation of peripheral ¿d17 T cells from adult bone marrow-derived precursors". EMBO reports 18 11 (2017): 1957-1967. https://doi.org/10.15252/embr.201744200.
    10.15252/embr.201744200
  41. Santos, Bruno. "Primary Tumors Limit Metastasis Formation through Induction of IL15-Mediated Cross-Talk between Patrolling Monocytes and NK Cells.". Cancer immunology research (2017): https://doi.org/10.1158/2326-6066.CIR-17-0082.
    10.1158/2326-6066.cir-17-0082
  42. Santos, Bruno. "Peripheral clonal selection shapes the human ¿d T-cell repertoire.". Cellular & molecular immunology (2017): https://europepmc.org/articles/PMC5596248.
    10.1038/cmi.2017.51
  43. Santos, Bruno. "Strong TCR¿d Signaling Prohibits Thymic Development of IL-17A-Secreting ¿d T Cells.". Cell reports (2017): https://europepmc.org/articles/PMC5489697.
    10.1016/j.celrep.2017.05.071
  44. Santos, Bruno. "IL-17+ ¿d T cells as kick-starters of inflammation.". Nature immunology (2017): https://doi.org/10.1038/ni.3726.
    10.1038/ni.3726
  45. Santos, Bruno. "Thymic Determinants of ¿d T Cell Differentiation.". Trends in immunology (2017): https://doi.org/10.1016/j.it.2017.01.007.
    10.1016/j.it.2017.01.007
  46. Santos, Bruno. "¿d T cells get adaptive.". Nature immunology (2017): https://doi.org/10.1038/ni.3705.
    10.1038/ni.3705
  47. Ribot JC; Serre K; Silva-Santos B. "Developmental and Functional Assays to Study Murine and Human ¿d T Cells.". (2017): http://europepmc.org/abstract/med/27787805.
  48. Almeida AR; Correia DV; Fernandes-Platzgummer A; da Silva CL; da Silva MG; Anjos DR; Silva-Santos B. "Delta One T Cells for Immunotherapy of Chronic Lymphocytic Leukemia: Clinical-Grade Expansion/Differentiation and Preclinical Proof of Concept.". (2016): http://europepmc.org/abstract/med/27307596.
  49. Henriques A; Silva C; Santiago M; Henriques MJ; Martinho A; Trindade H; da Silva JA; Silva-Santos B; Paiva A. "Subset-specific alterations in frequencies and functional signatures of ¿d T cells in systemic sclerosis patients.". (2016): http://europepmc.org/abstract/med/27576328.
  50. Ribeiro ST; Tesio M; Ribot JC; Macintyre E; Barata JT; Silva-Santos B. "Casein kinase 2 controls the survival of normal thymic and leukemic ¿d T cells via promotion of AKT signaling.". (2016): http://europepmc.org/abstract/med/27899804.
    10.1038/leu.2016.363
  51. Silva-Santos B; Di Santo J; Reis E Sousa C. "Immunology's Twinning Triangle.". (2016): http://europepmc.org/abstract/med/27726145.
    10.1002/eji.201670106
  52. Caiado F; Silva-Santos B; Norell H. "Intra-tumour heterogeneity - going beyond genetics.". (2016): http://europepmc.org/abstract/med/26945550.
    10.1111/febs.13705
  53. Muñoz-Ruiz M; Ribot JC; Grosso AR; Gonçalves-Sousa N; Pamplona A; Pennington DJ; Regueiro JR; Fernández-Malavé E; Silva-Santos B. "TCR signal strength controls thymic differentiation of discrete proinflammatory ¿d T cell subsets.". (2016): http://europepmc.org/abstract/med/27043412.
    10.1038/ni.3424
  54. Barros-Martins J; Schmolka N; Fontinha D; Pires de Miranda M; Simas JP; Brok I; Ferreira C; et al. "Effector ¿d T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors.". (2016): http://europepmc.org/abstract/med/26994218.
    10.4049/jimmunol.1501921
  55. Silva-Santos B; Serre K; Norell H. "¿d T cells in cancer.". (2015): http://europepmc.org/abstract/med/26449179.
    10.1038/nri3904
  56. Bonneville M; Chen ZW; Déchanet-Merville J; Eberl M; Fournié JJ; Jameson JM; Lopez RD; Massaia M; Silva-Santos B. "Chicago 2014--30 years of ¿d T cells.". (2015): http://europepmc.org/abstract/med/25468804.
    10.1016/j.cellimm.2014.11.001
  57. Amado T; Schmolka N; Metwally H; Silva-Santos B; Gomes AQ. "Cross-regulation between cytokine and microRNA pathways in T cells.". (2015): http://europepmc.org/abstract/med/25865116.
    10.1002/eji.201545487
  58. Rei M; Pennington DJ; Silva-Santos B. "The emerging Protumor role of ¿d T lymphocytes: implications for cancer immunotherapy.". (2015): http://europepmc.org/abstract/med/25660949.
    10.1158/0008-5472.can-14-3228
  59. Schmolka N; Wencker M; Hayday AC; Silva-Santos B. "Epigenetic and transcriptional regulation of ¿d T cell differentiation: Programming cells for responses in time and space.". (2015): http://europepmc.org/abstract/med/25726512.
    10.1016/j.smim.2015.01.001
  60. Ribeiro ST; Ribot JC; Silva-Santos B. "Five Layers of Receptor Signaling in ¿d T-Cell Differentiation and Activation.". (2015): http://europepmc.org/abstract/med/25674089.
    10.3389/fimmu.2015.00015
  61. Galluzzi L; Vacchelli E; Bravo-San Pedro JM; Buqué A; Senovilla L; Baracco EE; Bloy N; et al. "Classification of current anticancer immunotherapies.". (2014): http://europepmc.org/abstract/med/25537519.
  62. Rei M; Gonçalves-Sousa N; Lança T; Thompson RG; Mensurado S; Balkwill FR; Kulbe H; Pennington DJ; Silva-Santos B. "Murine CD27(-) V¿6(+) ¿d T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.". (2014): http://europepmc.org/abstract/med/25114209.
    10.1073/pnas.1403424111
  63. Ribot JC; Ribeiro ST; Correia DV; Sousa AE; Silva-Santos B. "Human ¿d thymocytes are functionally immature and differentiate into cytotoxic type 1 effector T cells upon IL-2/IL-15 signaling.". (2014): http://europepmc.org/abstract/med/24489097.
    10.4049/jimmunol.1303119
  64. Serre K; Silva-Santos B. "Molecular Mechanisms of Differentiation of Murine Pro-Inflammatory ¿d T Cell Subsets.". (2013): http://europepmc.org/abstract/med/24367369.
    10.3389/fimmu.2013.00431
  65. Norell H; Moretta A; Silva-Santos B; Moretta L. "At the bench: Preclinical rationale for exploiting NK cells and ¿d T lymphocytes for the treatment of high-risk leukemias.". (2013): http://europepmc.org/abstract/med/24108703.
    10.1189/jlb.0613312
  66. Schmolka N; Serre K; Grosso AR; Rei M; Pennington DJ; Gomes AQ; Silva-Santos B. "Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory ¿d T cell subsets.". (2013): http://europepmc.org/abstract/med/23995235.
    10.1038/ni.2702
  67. Lança T; Silva-Santos B. "Recruitment of ¿d T lymphocytes to tumors: A new role for the pleiotropic chemokine CCL2.". (2013): http://europepmc.org/abstract/med/24179705.
    10.4161/onci.25461
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  78. Hudspeth K; Fogli M; Correia DV; Mikulak J; Roberto A; Della Bella S; Silva-Santos B; Mavilio D. "Engagement of NKp30 on Vd1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication.". (2012): http://europepmc.org/abstract/med/22403253.
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  79. Silva-Santos B. "¿d cells making IL-17.". (2011): http://europepmc.org/abstract/med/21737606.
    10.1182/blood-2011-05-351726
  80. Correia DV; Fogli M; Hudspeth K; da Silva MG; Mavilio D; Silva-Santos B. "Differentiation of human peripheral blood Vd1+ T cells expressing the natural cytotoxicity receptor NKp30 for recognition of lymphoid leukemia cells.". (2011): http://europepmc.org/abstract/med/21633088.
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  81. Ribot JC; debarros A; Silva-Santos B. "Searching for "signal 2": costimulation requirements of ¿d T cells.". (2011): http://europepmc.org/abstract/med/21541698.
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  82. DeBarros A; Chaves-Ferreira M; d'Orey F; Ribot JC; Silva-Santos B. "CD70-CD27 interactions provide survival and proliferative signals that regulate T cell receptor-driven activation of human ¿d peripheral blood lymphocytes.". (2011): http://europepmc.org/abstract/med/21182090.
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  83. Mahtani-Patching J; Neves JF; Pang DJ; Stoenchev KV; Aguirre-Blanco AM; Silva-Santos B; Pennington DJ. "PreTCR and TCR¿d signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization.". (2011): http://europepmc.org/abstract/med/21775286.
    10.1126/scisignal.2001765
  84. Douradinha B; van Dijk M; van Gemert GJ; Khan SM; Janse CJ; Waters AP; Sauerwein RW; et al. "Immunization with genetically attenuated P52-deficient Plasmodium berghei sporozoites induces a long-lasting effector memory CD8+ T cell response in the liver.". (2011): http://europepmc.org/abstract/med/22004696.
    10.1186/1476-8518-9-6
  85. Gomes AQ; Martins DS; Silva-Santos B. "Targeting ¿d T lymphocytes for cancer immunotherapy: from novel mechanistic insight to clinical application.". (2010): http://europepmc.org/abstract/med/21159627.
    10.1158/0008-5472.CAN-10-3236
  86. Ribot JC; Chaves-Ferreira M; d'Orey F; Wencker M; Gonçalves-Sousa N; Decalf J; Simas JP; Hayday AC; Silva-Santos B. "Cutting edge: adaptive versus innate receptor signals selectively control the pool sizes of murine IFN-¿- or IL-17-producing ¿d T cells upon infection.". (2010): http://europepmc.org/abstract/med/21037088.
    10.4049/jimmunol.1002283
  87. Monteiro M; Almeida CF; Caridade M; Ribot JC; Duarte J; Agua-Doce A; Wollenberg I; Silva-Santos B; Graca L. "Identification of regulatory Foxp3+ invariant NKT cells induced by TGF-beta.". (2010): http://europepmc.org/abstract/med/20639482.
    10.4049/jimmunol.1000359
  88. Gomes AQ; Correia DV; Grosso AR; Lança T; Ferreira C; Lacerda JF; Barata JT; Silva MG; Silva-Santos B. "Identification of a panel of ten cell surface protein antigens associated with immunotargeting of leukemias and lymphomas by peripheral blood gammadelta T cells.". (2010): http://europepmc.org/abstract/med/20220060.
    10.3324/haematol.2009.020602
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Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2020/02/20 . Differentiation of effector gamma-delta T cell subsets: implications for Neuro- and Onco-Immunology. Karolinska Institute, Stockholm, Sweden, April 2, 2020. . Differentiation of effector gamma-delta T cell subsets: focus on metabolic programming. EMBO Investigator Meeting, Malaga, Spain, February 20, 2020. . Differentiation of effector T cell subsets: microRNAs and metabolic programming. University of Toulouse, Toulouse, France, January 23, 2020.
2019/11/28 . Differentiation of gamma-delta T cell subsets and key roles in severe malaria. University of Edinburgh, Edinburgh, UK, November 28, 2019. . (Patho)physiological roles of gamma-delta T cells in tissues. Annual Meeting of the Spanish Society for Immunology, Seville, Spain, May 30, 2019. . Unantecipated roles for tissue-resident gamma-delta T cells in infection and beyond. Lydia Becker Institute, University of Manchester, Manchester, UK, May 23, 2019.
2019/05/01 . Unantecipated links between gamma-delta T cells and the brain: cerebral malaria and working memory. Harvard Medical School, Boston, USA, May 2, 2019 . Unexpected roles for tissue-resident gamma-delta T cells. Rockefeller Institute, New York, USA, May 1, 2019. . Gamma-delta T cells: new roles for old cells. Stony Brook Symposium, Stony Brook (New York), USA, April 29, 2019.
2019/03/27 . Meningeal gamma-delta T cells producing IL-17 promote short-term memory. 13th World Immune Regulation Meeting, Davos, Switzerland, April 9, 2019. . Gamma-delta T cells: pleiotropic roles and therapeutic potential. Cancer Immunotherapy Workshop, Champalimaud Centre for the Unknown, Lisbon, Portugal, March 27-29, 2019. . Gamma-delta T cell differentiation and roles in immunity. First Symposium of Jinan University-iMM, Guangzhou, China, January 12, 2019.
2018/10/25 . Innovative cell therapy in cancer – Delta One T cells, European Society of Immunodeficiencies Meeting, Lisbon, October 25, 2018 . Silva-Santos B., Regulation of gamma-delta T cell functions in the tumor microenvironment. Reunião Anual da Sociedade Brasileira de Imunologia, Ouro Preto, Brazil, October 2, 2018 . Silva-Santos B., Gamma-delta T cell differentiation and cancer immunity. European Congress of Immunology. Amesterdam, The Netherlands, September 3, 2018
2018/07/28 . The atypical life of unconventional T cells. University of Zurich Hospital, Zurique (Suiça), 6 de julho de 2018 . ?d T cells as main source of (patho)physiological IL-17 in non-lymphoid tissues. Institut Pasteur, Paris (França), 18 de junho de 2018 . Pleiotropic roles of IL-17+ ?d T cells: host defense, cognition, tumor progression. Hannover Medical School, Hanover (Alemanha), 11 de abril de 2018 . From Onco to Neuro: unantecipated findings on tissue-resident ?d T cells. Instituto Gulbenkian de Ciência, Oeiras, 16 de fevereiro de 2018
2017/08/29 . Atypical functions and regulation of IL-17+ ?d T cells in tissues. 2nd Interdisciplinary Congress on IL-17, Munich (Germany), 25 November 2017. . IL-17+ gd T cells in health and disease. Basel Immunology Symposium, Basel (Switzerland), 29 August 2017. . Atypical roles for IL-17+ gamma-delta T cells in peripheral tissues. Francis Crick Institute, London (UK), 7 de julho de 2017 . Regulating and manipulating gamma-delta T cells in cancer immunotherapy. King’s College London, London (Reino Unido), 27 de junho de 2017
2016/12/09 . Differentiation and functions of pro-inflammatory gamma-delta T cells. Medical School, University of Toronto (Canada), 13 April 2017. . Development of pro-inflammatory gamma-delta T cell subsets. CS&D Masterclass, University Medical Center Utrecht (The Netherlands), 9 December 2016. . Gamma-delta T cells and leukaemia. Cancer Research UK – Manchester Research Institute (United Kingdom), 10 November 2016. . Development and functions of pro-inflammatory gamma-delta T cell subsets. Université de Toulouse (France), 10 October 2016.
2016/08/21 . Immunomodulation of Plasmodium pathogenicity by hepatic gamma-delta T cells in experimental cerebral malaria. 16th International Congress of Immunology, Melbourne (Australia), 21-26 August 2016. . Vdelta1 T cells expressing natural cytotoxicity receptors for adoptive cell therapy of leukemia. 16th International Congress of Immunology, Melbourne (Australia), 21-26 August 2016. . Gamma-delta T cells dictate Plasmodium pathogenicity in experimental cerebral malaria. 7th International Gamma-delta T Cell Conference, London (UK), 16-19 June 2016.
2016/01/11 . Gamma-delta T cells and leukemia. The Netherlands Cancer Institute, Amsterdam (The Netherlands), 20 May 2016. . Gamma-delta T lymphocytes in the tumour environment: from oncoimmunology to aoptive immunotherapy. 2nd International Congress of ASPIC - Associação Portuguesa de Investigação sobre o Cancro, Porto, 28 April 2016. . Gamma-delta T cells in Tumor Immunology. Institut fur Immunologie und Virologie, Wurzburg (Germany), 11 January 2016. . Pro-inflammatory gamma-delta T cells: differentiation and tumor targeting. Karolinska Institute
2015/07/16 . Pro-finflammatory gamma-delta T cells: differentiation and tumor targeting. Zing Conference – The immune system for therapeutic benefit. Oropesa (Spain), 3 October 2015. . Functional differntiation and tumor targeting by gamma-delta T cells. Institut Necker Enfants Malades, Paris (France3), 18 September 2015. . Molecular determinants of gamma-delta T cell differentiation. Institut fur Immunologie, Ludwig-Maximilian University, Munich (Germany), 16 July 2015. . Functional subsets of gamma-delta T lymphocytes defined by flow cytometry analy
2015/03/04 . Gamma-delta T cell differentiation and tumor targeting. University of Lund (Sweden), 4 May 2015. . Of Mice and Men: Gamma-delta T cell responses to tumors. University of Palermo (Italy), 4 March 2015. . Molecular mechanisms of differentiation of effector gamma-delta T cell subsets. The 43rd Annual Meeting of the Japanese Society for Immunology, Kyoto (Japan), 11 December 2014. . Unconventional mechanisms of effector gamma-delta T cell differentiation. The British Society for Immunology Annual Congress, Brighton (United Kingdom), 3 Decembe
2013/08/26 . Molecular mechanisms of differentiation of immunoregulatory T cell subsets. Annual Meeting of the French Society of Immunology, Paris (France), 4-7 November 2013. . Activation of gamma-delta T cells for targeting of human tumours. Symposium of the Tumour Infiltrating Myeloid Cells Consortium, London (UK), 7 October 2013. . Molecular mechanisms of differentiation of gamma-delta T lymphocytes. 15th International Congress of Immunology, Milan (Italy), 26 August 2013. . Molecular mechanisms of differentiation of effector and regulatory T cell
2012/11/25 . Molecular determinants of T lymphocyte differentiation. Blizard Institute, Queen Mary College London (UK), 18 December 2012. . Differentiation of IL-17-producing gamma-delta T cells. Masterclass of the 7th European Workshop on Immune-Mediated Inflammatory Diseases, Noordwijk an Zee (The Netherlands), 27-28 November 2012. . gd T cells within tumors: recruitment, recognition and functions. XXXVIII Annual Meeting of the Portuguese Society of Immunology (Porto), 25-27 November 2012.
2012/02/07 . Natural killer receptors in tumor cell recognition by human gd T cells. 2nd International Conference of Translational Medicine on Immune-Mediated Diseases, Milan (Italy), 5-8 November 2012. . "Molecular mechanisms of differentiation of IL-17-producing gamma-delta T cells". International Cytokine Society meeting on IL-17 and related cytokines. Dublin (Ireland), 20 June 2012. . "In vivo differentiation and expansion of gamma-delta T cells". Keystone Symposium on Th17 cells in health and disease. Keystone (USA), 7 February 2012.
2011/05/16 . "Education at birth: the development of gamma-delta T cells". European Research Council, Brussels (Belgium). 9 December 2011. . "Activation and expansion of Th17- or Th1-like gd cell subsets are controlled by distinct receptors associated with innate or adaptive immunity". 4th Angean Conference on Innate and Adaptive Immunity. Mykonos (Greece), 12 September 2011. . "Molecular mechanisms of tumor cell recognition by human gd T lymphocytes". Institut Necker, Faculté de Médecine, Université Paris Descartes, Paris (France). 16 May 2011
2009/10/05 . "Differentiation and activation of gd T lymphocytes", Universidade Federal do Rio de Janeiro (Brazil), 28/2/2011. . "CD70-CD27 costimulation in gd T cell differentiation and activation. College of Life Sciences, University of Dundee (United Kingdom), 1/7/2010. . "gd T cell differentiation and activation: the role of the CD27 receptor". Institut Pasteur, Paris (France), 26/10/2009. . "Critical receptors in gd T cell differentiation and activation". Instituto Clinico Humanitas, Milan (Italy), 5/10/2009.
2009/05/14 . "Critical receptors for gd T cell differentiation and activation". XXXV Annual Meeting of the Portuguese Society of Immunology, Lisbon (Portugal), 28-30/9/2009. . "The role of CD27 in gd T cell differentiation", The Netherlands Cancer Institute, Amsterdam, 8/6/2009. . "Functional T cell differentiation during thymocyte development", EMBO Young Investigator Meeting, Istanbul (Turkey), 14/5/2009. . "To make Interferon-gamma or Interleukin-17: functional T cell differentiation begins in the thymus", King's College London, UK, 2/12/2008
Distinções

Prémio

2021 Prémio Científico Universidade de Lisboa - Saúde
Universidade de Lisboa, Portugal
2020 Prémio Pfizer em Investigação Básica
2019 Prémio FAZ Ciência 2019
AstraZeneca AB, Suécia
2009 Pfizer Award in Clinical Research
2005 Young Researcher of the Year
King's College London, Reino Unido

Título

2019 EMBO Member
European Molecular Biology Laboratory, Alemanha

Outra distinção

2018 Prémio Janssen de Inovação
2016 Prémio Científico Universidade de Lisboa - Saúde
Universidade de Lisboa, Portugal
2016 Grande Prémio BIAL de Medicina - 2º lugar (Menção Honrosa)
Fundação Bial, Portugal
2012 Member of the European Academy of Tumor Immunology
2010 International Award – 5th Edition (2nd Prize)
Cooperativa de Ensino Superior Politécnico e Universitário, Portugal
2010 EMBO Young Investigator
European Molecular Biology Laboratory, Alemanha
2009 Young Investigator Award
2007 EMBO Installation Grantee
European Molecular Biology Laboratory, Alemanha
2007 FCT representative at the Lindau-Nobel Laureates Meeting (Physiology and Medicine)
Fundação para a Ciência e a Tecnologia, Portugal