Cecília Maria Pereira Rodrigues (DC18-39A7-F287)

Curriculum Vitae

Cecília Maria Pereira Rodrigues

Cecilia M.P. Rodrigues completed her degree in Pharmaceutical Sciences at the University of Lisbon in 1992, and later obtained her PhD in Pharmacy (Biochemistry) in 1996 from the same institution, after completing PhD training at the University of Cincinnati, OH, USA under the guidance of K.D.R. Setchell. She then pursued postdoctoral work at the University of Minnesota, MN, USA with C.J. Steer. Since 2009, she has held the position of Full Professor at the Faculty of Pharmacy, University of Lisbon. Rodrigues has published close to 300 indexed peer-reviewed papers, 20 book chapters and 4 global coverage patents (h-index 70 and ca. 24,000 citations in Scopus). Her research interests are discovering novel mechanism-based molecular targets for therapeutic intervention and diagnosis in inflammatory, neurodegenerative and oncogenic diseases. Rodrigues leads a laboratory that focuses on signalling pathways involved in cell death, differentiation and proliferation, as well as interorgan communication by bile acids and other biomolecules. She uses relevant experimental models and patient samples, and employs genetic and pharmacological strategies to interrogate transcriptomics and proteomics profiles. Her research has developed promising technologies protected by global patents and explored by spin-offs that have moved to clinical trials worldwide. Rodrigues has held leadership positions, including founder and Head of Department (2021; 2011-18) at the Faculty of Pharmacy, University of Lisbon, and Director of the Research Institute for Medicines (2013-20). Currently, she is vice-rector for Research and Innovation at the University of Lisbon (2021-25). She created and currently directs the PhD Programme in Medicines and Pharmaceutical Innovation (2015-present) and the Master Course in Biopharmaceutical Sciences (2010-present). She has supervised close to 100 PhD students and postdoctoral scientists, and 80 MSc students. Rodrigues has received awards, including the EASL Sheila Sherlock Award in 2000 and most recently the Krebs Medal FENS in 2022. She has been invited to speak at international conferences and has served on various national and international editorial (Hepatology, Journal of Hepatology) and grant review (FCT Portugal, A3ES Portugal, BMBF Germany, MRC UK, ARN and CNRS France, ISCIII Spain, MOH Italy, and SFI Ireland) boards. Rodrigues has secured independent funding from public competitive sources and/or through private investment, amounting to ca. 20 M€. She has a background in technology transfer, technology commercialization and academic-industrial collaborations, including with AstraZeneca Open Innovation, UK. ORCID ID: 0000-0002-4829-754X; Scopus Author ID: 7202508239; Researcher ID: M-3572-2013; Ciência ID DC18-39A7-F287.

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Identificação

Identificação pessoal

Nome completo: Cecília Maria Pereira Rodrigues

Nomes de citação

Rodrigues, CMP
Rodrigues, CM
Rodrigues, C

Identificadores de autor

Ciência ID: DC18-39A7-F287
ORCID iD: 0000-0002-4829-754X
Researcher Id: M-3572-2013
Scopus Author Id: 7202508239

Endereços de correio eletrónico

cmprodrigues@ff.ulisboa.pt (Profissional)

Telefones

Fax

217946491 (Profissional)

Telefone

217946490 (Profissional)

Moradas

iMed.ULisboa, Faculdade de Farmácia, Universidade de Lisboa. Av. Prof. Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Profissional)

Websites

https://imed.ulisboa.pt/cv/cecilia-maria-pereira-rodrigues/ (Académico)
http://www.imed.ulisboa.pt/ (Académico)
http://www.ff.ul.pt/ (Académico)

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Francês	Utilizador independente (B1)	Utilizador independente (B2)	Utilizador independente (B1)	Utilizador independente (B2)	Utilizador independente (B1)
Espanhol; Castelhano	Utilizador independente (B2)	Utilizador independente (B2)	Utilizador independente (B1)	Utilizador independente (B2)	Utilizador independente (B2)

Formação

	Grau	Classificação
2005/09/13 Concluído	Pharmacy (Título de Agregado) Especialização em Biological Sciences Universidade de Lisboa Faculdade de Farmácia, Portugal "Modulation of Apoptosis by Bile Acids. Lição de síntese apresentada em provas de habilitação ao título de Agregada no 2º Grupo de Ciências Biológicas da Faculdade de Farmácia da Universidade de Lisboa" (TESE/DISSERTAÇÃO)	Approved
1996/03/01 Concluído	Pharmacy (Doutoramento) Especialização em Biochemistry Universidade de Lisboa Faculdade de Farmácia, Portugal "The metabolism of ursodeoxycholic acid: basic and clinical studies" (TESE/DISSERTAÇÃO)	Approved with Distinction and Honor
1992 Concluído	Pharmaceutical Sciences (Licenciatura) Universidade de Lisboa Faculdade de Farmácia, Portugal "n/a" (TESE/DISSERTAÇÃO)	Excellent: Eighteen (18/20)

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
1996 - 1999	Pós-doutorado (Investigação)	University of Minnesota, Estados Unidos
	University of Minnesota, Estados Unidos
1992 - 1995	Investigador (Investigação)	University of Cincinnati, Estados Unidos

Docência no Ensino Superior

	Categoria Profissional Instituição de acolhimento	Empregador
2009 - Atual	Professor Catedrático (Docente Universitário)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal
2006 - 2009	Professor Associado (Docente Universitário)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal
2004 - 2006	Professor Auxiliar (Docente Universitário)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal
1999 - 2004	Assistente (Docente Universitário)	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal

Cargos e Funções

	Categoria Profissional Instituição de acolhimento	Empregador
2021/10/01 - 2025/09/30	Vice-Reitor	Universidade de Lisboa, Portugal
	Universidade de Lisboa, Portugal
2021/01/01 - 2021/10/01	Presidente de Unidade Orgânica	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2020	Director de Unidade Orgânica	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2007 - 2020	Dirigente de laboratório, instituto, museu, centro ou observatório	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2011 - 2018	Presidente de Unidade Orgânica	Universidade de Lisboa Faculdade de Farmácia, Portugal
	Universidade de Lisboa Faculdade de Farmácia, Portugal

Projetos

Bolsa

	Designação	Financiadores
1996 - 1999	Molecular Studies of Ursodeoxycholic Acid Therapeutic Effects, University of Minnesota, Minneapolis, MN, USA Bolsa BPD FCT Bolseiro de Pós-Doutoramento University of Minnesota, Estados Unidos	Fundação para a Ciência e a Tecnologia Concluído
1992 - 1995	The Metabolism of Ursodeoxycholic Acid: Basic and Clinical Studies, University of Cincinnati, Cincinnati, OH, USA Bolsa BD FCT Bolseiro de Doutoramento University of Cincinnati Academic Health Center, Estados Unidos	Fundação para a Ciência e a Tecnologia Concluído
1990 - 1992	Centro de Metabolismos e Genética, University of Lisbon, Lisbon, Portugal Bolsa BII Instituto Nacional de Investigação Científica (INIC) Bolseiro de Iniciação Científica Universidade de Lisboa Faculdade de Farmácia, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Projeto

	Designação	Financiadores
2024/01/01 - Atual	Total of ca. 70 projects (Principal Investigator in >35, generating ca. 20M Euro) Investigador responsável
2022/01/01 - 2024/12/31	Translating RIPK3 Signalling into Application in Metabolic Liver Disease PTDC/MED-FAR/3492/2021 Investigador responsável Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal	Em curso
2021/11/01 - 2024/10/30	RIPK3 Biology and Targeting in Metabolic Liver Disease LCF/PR/HR21/52410028 Investigador responsável Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2017 - 2024	LITMUS - Liver Investigation: Testing Marker Utility in Steatohepatitis IMI2 116125-2 H2020 Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	European Commission Em curso
2017/01 - 2021/12	FOIE GRAS - Bioenergetic remodeling in the pathophysiology and treatment of non-alcoholic fatty liver disease H2020 MSCA-ITN-ETN 2016 European Commission Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	European Commission Em curso
2018 - 2021	LiverBTT - Non-alcoholic Fatty Liver Disease: Emerging Biomarkers, Targets and Therapies PTDC/MED-FAR/29097/2017 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e Tecnologia Em curso
2018 - 2021	Exosomal Fat-Liver Axis in Non-Alcoholic Fatty Liver Disease: Function and Modulation PTDC/MED-PAT/31882/2017 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018 - 2021	Metabolic Control of Neural Repair by Diet and Gut Microbiome during Aging PTDC/MED-NEU/29650/2017 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018 - 2021	Nanoformulated Hybrid Molecules For Specific Targeting Melanoma Metastasis PTDC/MED-QUI/31721/2017 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018 - 2021	Drug discovery for p53 PPi-targets PTDC/QUI-QOR/29664/2017 Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018 - 2021	Targeting aquaporin-3 as a novel therapeutic approach for melanoma PTDC/BTM-SAL/28977/2017 Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2018 - 2021	Tricks or Treats? Toward Selective Organoruthenium(II) Glycoconjugated Anticancer Agents PTDC/MED-QUI/31468/2017 Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2017 - 2021	mitoFOIE GRAS - Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease H2020-MSCA-RISE-2016 734719 Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	H2020-MSCA-RISE-2016 Em curso
2017 - 2020	POINT4PAC - Precision Oncology by Innovative Therapies and Technologies COMPETE 2020 SAICTPAC/0019/2015 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2017 - 2019	Targeting the NAFLD-HCC continuum with bile acid-activated receptor agonists and microRNAs Intercept 2017 Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Intercept Pharmaceuticals Concluído
2016 - 2019	New Drugs to Treat Non-alcoholic Fatty Liver and Progression to Cancer PTDC/BIM-MEC/0895/2014 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2015 - 2018	High Throughput Screening With AstraZeneca's Compound library AZ HTS 2015 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	AstraZeneca UK Ltd Concluído
2015 - 2017	Role of Mitofusin 2 in Non-Alcoholic Fatty Liver Disease and Targeting by microRNAs Gilead Science International 2015 Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Gilead Sciences International Ltd Concluído
2013 - 2016	Treat Liver Disease by Targenting Hepatocyte Necroptosis HMSP-ICT/0018/2011 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Harvard Medical School Fundação para a Ciência e a Tecnologia Concluído
2013 - 2015	New Therapeutic Targets to Control Viral Hepatitis Gilead Science 2013 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Gilead Sciences Lda Concluído
2013 - 2015	Driving Mitochondrial Effectors of Apoptosis Toward Neural Differentiation info:eu-repo/grantAgreement/FCT/3599-PPCDT/124457/PT Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2012 - 2015	NecroPT - Targeting Hepatocyte Necroptosis to Treat Liver Diseases 119842 Provided by PTCRIS: 119842 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2012 - 2015	Interaction of bile acids with lipid membranes: creating a shield or bursting the bubble. info:eu-repo/grantAgreement/FCT/3599-PPCDT/119494/PT Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2012 - 2015	Oceanic Treasures - Oceanic sediments from the Madeira Archipelago: a new source of innovative and bioactive compounds PTDC/QUI-QUI/119116/2010 Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2012 - 2015	Functional compatibility of the replication complex as determinant of virulence in influenza virus info:eu-repo/grantAgreement/FCT/3599-PPCDT/122780/PT Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2012 - 2015	Aiming at microRNA-21 and bile acid activated receptors in non-alcoholic fatty liver disease pathogenesis: two bullets for one murder? PTDC/BIM-MEC/0873/2012 Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2012 - 2014	Preventing Memory Loss in Alzheimer's Disease: Underlying Mechanisms and Therapeutic Targets of Tauroursodeoxycholic Acid 117877 Provided by PTCRIS: 117877 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2011 - 2014	Modulation of amyloid beta-induced neuronal toxicity via JNK: a novel role for tauroursodeoxycholic acid info:eu-repo/grantAgreement/FCT/3599-PPCDT/112636/PT Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2011 - 2013	Targeting microRNA-34, a Potential Link between Apoptosis and Nonalcoholic Fatty Liver Disease Pathogenesis info:eu-repo/grantAgreement/FCT/3599-PPCDT/111930/PT Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2010 - 2013	The influence of bile acids in malaria hepatic infection PTDC/SAU-MII/099118/2008 Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2010 - 2012	Prevalence and severity of fatty liver in morbid obesity: correlation and mechanisms related with the role of ectopic fat in insulin resistance info:eu-repo/grantAgreement/FCT/3599-PPCDT/100878/PT Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2009 - 2012	Understanding microRNA Profiles and Cellular Functions in Colorectal Cancer 99162 Provided by PTCRIS: 99162 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2009 - 2012	Exploring New Roles for Endogenous Bile Acids and microRNAs in Modulating Liver Regeneration info:eu-repo/grantAgreement/FCT/3599-PPCDT/102099/PT Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2009 - 2011	Advancing the field of drug delivery - combined targeted treatments against human breast cancer and human leukemia (The OncotargetNanoMed network) 109361 Provided by PTCRIS: 109361 Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2009 - 2011	Modulation of liver regeneration by bile acids: role of miRNAs SPG 2008 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Sociedade Portuguesa de Gastrenterologia Concluído
2008 - 2011	Linking Fibrillogenesis and the Apoptosis Induced by Amyloid-beta Mutant Peptides 67922 Provided by PTCRIS: 67922 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2008 - 2011	Membrane receptors and mediators involved in plastic changes induced by neuronal insults: implications for neuroprotection Provided by PTCRIS: 68607 68607 Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2007 - 2010	Neurodegeneration in Alzheimer’s Disease Transgenic Mice: Role of Apoptosis and its Modulation 67912 Provided by PTCRIS: 67912 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2007 - 2009	Evaluation of the protective role of Glutathione S-Transferase pi against MPTP neurotoxicity Provided by PTCRIS: 82406 82406 Investigador Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2007 - 2009	Studies on genetic and physiological characterization of sheep adaptation to food restriction Provided by PTCRIS: 82574 82574 Investigador Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal	Universidade de Coimbra Concluído
2007 - 2009	Correlation between aggregation, fibril formation and apoptosis induced by APP missense mutations Pfizer 2007 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Pfizer Biofarmacêutica Sociedade Unipessoal Lda Concluído
2007 - 2009	Isolation, characterization and application of a unique population of liver derived stem cells ROCHE 2017 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Roche Farmaceutica Quimica Lda Concluído
2004 - 2009	Apoptosis and inflammatory response in colorectal carcinogenesis: interaction between p53, ß-catenin and TGFß pathways in prognosis and resistance to therapy FCG/68796/2004 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação Calouste Gulbenkian Concluído
2007 - 2008	Tauroursodeoxycholic Acid Protection of Compression Spinal Cord Injury: Targeting Cell Survival Cascades 82487 Provided by PTCRIS: 82487 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2005 - 2008	Bile Acid Mediated Inhibition of Neuronal Apoptosis 82322 Provided by PTCRIS: 82322 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2006 - 2007	Basic cellular mechanisms of anti-apoptotic signaling by bile acids FCG Estímulo 2005 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação Calouste Gulbenkian Concluído
2005 - 2007	Basic mechanisms of apoptosis in cells expressing an Alzheimer’s disease-associated double mutation FLAD/L-V-595/2004 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação Luso-Americana Concluído
2003 - 2007	Signaling events in tauroursodeoxycholic acid protection of amyloid ß-peptide-induced neuronal death POCTI/BCI/44929/2002 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído
2003 - 2005	Colorectal cancer and apoptosis: nutrition and cellular metabolism as risk factors SPG2002 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Sociedade Portuguesa de Gastrenterologia Concluído
2002 - 2004	Pathogenic mechanisms of injury in human alcoholic and non-alcoholic steatohepatitis: from oxidative stress to cell death by apoptosis SPGG2001 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Sociedade Portuguesa de Gastrenterologia Concluído
2000 - 2002	Role of mitochondria in bile acid-, bilirubin- and amyloid ß-peptide-induced apoptosis and protective effect of ursodeoxycholic acid and its conjugates EASLFellow2000 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	European Association for the Study of the Liver Concluído
1999 - 2001	Mechanisms of cell injury by glycochenodeoxycholic acid, bilirubin, and ß-amyloid. Role of ursodeoxycholic acid in preventing apoptosis by inhibiting mitochondrial cytochrome c release and caspase activation PRAXIS/C/SAU/14311/98 Investigador responsável Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal	Fundação para a Ciência e a Tecnologia Concluído

Produções

Publicações

Artigo em conferência	Condelipes, P.G.M.; Fontes, P.M.; Nikolaidou, K.; Marques, V.; Bras, E.J.S.; Afonso, M.B.; Rodrigues, C.M.P.; et al. "Development of a Microfluidic Colorectal Cancer Cell Culture System with Integrated Optical Sensors for Rapid Phage Selection". 2020. 10.1109/SENSORS47125.2020.9278738 Brás, E.J.S.; Condelipes, P.G.M.; Fontes, P.M.; Serrão, R.F.; Marques, V.; Afonso, M.B.; Rodrigues, C.M.P.; et al. "Development of a microfluidic platform for targeted phage selection: In pursuit of personalized colorectal cancer treatments". 2019.
Artigo em revista	Rodrigues, CMP. "Total of ca. 300 indexed peer-reviewed publications (300 papers; 20 book chapters; 1 book; 6 patents; Google Scholar: h-index 85; ca. 44000 citations; Scopus: h-index 70; ca. 24000 citations)". (2024): Duarte-Silva, Sara; Da Silva, Jorge Diogo; Monteiro-Fernandes, Daniela; Costa, Marta Daniela; Neves-Carvalho, Andreia; Raposo, Mafalda; Soares-Cunha, Carina; et al. "Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of spinocerebellar ataxia type 3". Journal of Clinical Investigation 134 5 (2024): http://dx.doi.org/10.1172/jci162246. 10.1172/jci162246 Nunes, Maria João; Carvalho, Andreia Neves; Reis, Joana; Costa, Daniela; Moutinho, Miguel; Mateus, Joana; Mendes de Almeida, Rita; et al. "Cholesterol redistribution triggered by CYP46A1 gene therapy improves major hallmarks of Niemann-Pick type C disease but is not sufficient to halt neurodegeneration". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870 3 (2024): 166993. http://dx.doi.org/10.1016/j.bbadis.2023.166993. 10.1016/j.bbadis.2023.166993 Nunes, M.J.; Carvalho, A.N.; Sá-Lemos, C.; Colaço, M.; Cervenka, I.; Ciraci, V.; Santos, S.G.; et al. "Sustained PGC-1a2 or PGC-1a3 expression induces astrocyte dysfunction and degeneration". European Journal of Cell Biology 103 1 (2024): 151377. http://dx.doi.org/10.1016/j.ejcb.2023.151377. 10.1016/j.ejcb.2023.151377 Caria, Inês; Nunes, Maria João; Ciraci, Viviana; Carvalho, Andreia Neves; Ranito, Catarina; Santos, Susana G.; Gama, Maria João; et al. "NPC1-like phenotype, with intracellular cholesterol accumulation and altered mTORC1 signaling in models of Parkinson's disease". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1870 2 (2024): 166980. http://dx.doi.org/10.1016/j.bbadis.2023.166980. 10.1016/j.bbadis.2023.166980 Despoina Varamogianni-Mamatsi; Maria João Nunes; Vanda Marques; Thekla I. Anastasiou; Eirini Kagiampaki; Emmanouela Vernadou; Thanos Dailianis; et al. "Comparative Chemical Profiling and Antimicrobial/Anticancer Evaluation of Extracts from Farmed versus Wild Agelas oroides and Sarcotragus foetidus Sponges". Marine Drugs (2023): https://doi.org/10.3390/md21120612. 10.3390/md21120612 André, Ana S.; Dias, Joana N. R.; Aguiar, Sandra I.; Leonardo, Ana; Nogueira, Sara; Amaral, Joana D.; Fernandes, Célia; et al. "Panobinostat-loaded folate targeted liposomes as a promising drug delivery system for treatment of canine B-cell lymphoma". Frontiers in Veterinary Science 10 (2023): http://dx.doi.org/10.3389/fvets.2023.1236136. 10.3389/fvets.2023.1236136 Vanda Marques; Fabiola Arella; Marta B. Afonso; André A. Santos; Cecília M.P. Rodrigues. "Decoding the role of leptin and adiponectin in obesity-related gastrointestinal cancer". Clinical Science (2023): https://doi.org/10.1042/CS20230411. 10.1042/CS20230411 Rodrigues PM; Afonso MB; Simão AL; Islam T; Gaspar MM; O'Rourke CJ; Lewinska M; et al. "miR-21-5p promotes NASH-related hepatocarcinogenesis.". Liver international : official journal of the International Association for the Study of the Liver (2023): http://europepmc.org/abstract/med/37534739. 10.1111/liv.15682 Mózes, Ferenc E; Lee, Jenny A; Vali, Yasaman; Alzoubi, Osama; Staufer, Katharina; Trauner, Michael; Paternostro, Rafael; et al. "Performance of non-invasive tests and histology for the prediction of clinical outcomes in patients with non-alcoholic fatty liver disease: an individual participant data meta-analysis". The Lancet Gastroenterology & Hepatology 8 8 (2023): 704-713. http://dx.doi.org/10.1016/s2468-1253(23)00141-3. 10.1016/s2468-1253(23)00141-3 Matos, Ana I.; Peres, Carina; Carreira, Barbara; Moura, Liane I. F.; Acúrcio, Rita C.; Vogel, Theresa; Wegener, Erik; et al. "Polyoxazoline-Based Nanovaccine Synergizes with Tumor-Associated Macrophage Targeting and Anti-PD-1 Immunotherapy against Solid Tumors". Advanced Science 10 25 (2023): http://dx.doi.org/10.1002/advs.202300299. 10.1002/advs.202300299 Einer, Claudia; Munk, Ditte Emilie; Park, Eok; Akdogan, Banu; Nagel, Judith; Lichtmannegger, Josef; Eberhagen, Carola; et al. "ARBM101 (Methanobactin SB2) Drains Excess Liver Copper via Biliary Excretion in Wilson’s Disease Rats". Gastroenterology 165 1 (2023): 187-200.e7. http://dx.doi.org/10.1053/j.gastro.2023.03.216. 10.1053/j.gastro.2023.03.216 Pinho, Jacinta O.; Matias, Mariana; Godinho-Santos, Ana; Amaral, Joana D.; Mendes, Eduarda; Perry, Maria Jesus; Francisco, Ana Paula; Rodrigues, Cecília M.P.; Gaspar, M. Manuela. "A step forward on the in vitro and in vivo assessment of a novel nanomedicine against melanoma". International Journal of Pharmaceutics 640 (2023): 123011. http://dx.doi.org/10.1016/j.ijpharm.2023.123011. 10.1016/j.ijpharm.2023.123011 Vitale, Ilio; Pietrocola, Federico; Guilbaud, Emma; Aaronson, Stuart A.; Abrams, John M.; Adam, Dieter; Agostini, Massimiliano; et al. "Apoptotic cell death in disease—Current understanding of the NCCD 2023". Cell Death & Differentiation 30 5 (2023): 1097-1154. http://dx.doi.org/10.1038/s41418-023-01153-w. 10.1038/s41418-023-01153-w Fernando Capela e Silva; Cecília M. P. Rodrigues. "Apoptosis—50 Years after Its Discovery". Biomedicines (2023): https://doi.org/10.3390/biomedicines11041196. 10.3390/biomedicines11041196 Cristiana Domingues; Pedro Mendes Fontes; Pedro G. M. Condelipes; Vanda Marques; Marta B. Afonso; Virginia Chu; Cecília M. P. Rodrigues; João Pedro Conde. "Microfluidic Detection of Adenylate Kinase as a Cell Damage Biomarker". Chemosensors (2023): https://doi.org/10.3390/chemosensors11040220. 10.3390/chemosensors11040220 Joana Lopes; Tânia Ferreira-Gonçalves; Lia Ascensão; Ana S. Viana; Lina Carvalho; José Catarino; Pedro Faísca; et al. "Safety of Gold Nanoparticles: From In Vitro to In Vivo Testing Array Checklist". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15041120. 10.3390/pharmaceutics15041120 Marta Clariano; Vanda Marques; João Vaz; Salma Awam; Marta B. Afonso; Maria Jesus Perry; Cecília MP Rodrigues. "Monocarbonyl Analogs of Curcumin with Potential to Treat Colorectal Cancer". Chemistry & Biodiversity (2023): https://doi.org/10.1002/cbdv.202300222. 10.1002/cbdv.202300222 Lee, Jenny; Westphal, Max; Vali, Yasaman; Boursier, Jerome; Petta, Salvatorre; Ostroff, Rachel; Alexander, Leigh; et al. "Machine learning algorithm improves the detection of NASH (NAS-based) and at-risk NASH: A development and validation study". Hepatology 78 1 (2023): 258-271. http://dx.doi.org/10.1097/hep.0000000000000364. 10.1097/hep.0000000000000364 Afonso, Marta B.; Marques, Vanda; van Mil, Saskia W. C.; Rodrigues, Cecilia M. P.. "Human liver organoids: From generation to applications". Hepatology Publish Ah (2023): http://dx.doi.org/10.1097/hep.0000000000000343. 10.1097/hep.0000000000000343 Gnocchi, Davide; Afonso, Marta B.; Cavalluzzi, Maria Maddalena; Lentini, Giovanni; Ingravallo, Giuseppe; Sabbà, Carlo; Rodrigues, Cecilia M. P.; Mazzocca, Antonio. "Inhibition of lysophosphatidic acid receptor 6 upregulated by the choline-deficient l-amino acid-defined diet prevents hepatocarcinogenesis in mice". Molecular Carcinogenesis 62 5 (2023): 577-582. http://dx.doi.org/10.1002/mc.23516. 10.1002/mc.23516 Santos A; Delgado TC; Marques V; Moncayo CR; Alonso C; Vidal-Puig A; Hall Z; Martínez-Chantar ML; Rodrigues CMP. "Spatial metabolomics and its application in the liver.". Hepatology (Baltimore, Md.) (2023): http://europepmc.org/abstract/med/36811413. 10.1097/hep.0000000000000341 Pinho, Jacinta O.; Matias, Mariana; Marques, Vanda; Eleutério, Carla; Fernandes, Célia; Gano, Lurdes; Amaral, Joana D.; et al. "Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management". Biomedicine & Pharmacotherapy 157 (2023): 114021. http://dx.doi.org/10.1016/j.biopha.2022.114021. 10.1016/j.biopha.2022.114021 Gnocchi, D.; Afonso, M.B.; Cavalluzzi, M.M.; Lentini, G.; Ingravallo, G.; Sabbà, C.; Rodrigues, C.M.P.; Mazzocca, A.. "Inhibition of lysophosphatidic acid receptor 6 upregulated by the choline-deficient l-amino acid-defined diet prevents hepatocarcinogenesis in mice". Molecular Carcinogenesis (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85147505019&partnerID=MN8TOARS. 10.1002/mc.23516 Pinho, J.O.; Matias, M.; Marques, V.; Eleutério, C.; Fernandes, C.; Gano, L.; Amaral, J.D.; et al. "Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management". Biomedicine and Pharmacotherapy 157 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85141996153&partnerID=MN8TOARS. 10.1016/j.biopha.2022.114021 Rodrigues, Cecília M. P.. "Modulation of rectal cancer stemness, patient outcome and therapy response by adipokines". Journal of Physiology and Biochemistry 79 2 (2023): 261-272. doi: 10.1007/s13105-022-00936-y. Publicado Vanda Marques; Susana Ourô; Marta B. Afonso; Cecília M. P. Rodrigues. "Modulation of rectal cancer stemness, patient outcome and therapy response by adipokines". Journal of Physiology and Biochemistry (2022): https://doi.org/10.1007/s13105-022-00936-y. 10.1007/s13105-022-00936-y Afonso, Marta B.; Islam, Tawhidul; Magusto, Julie; Amorim, Ricardo; Lenoir, Véronique; Simões, Rui F.; Teixeira, José; et al. "RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease". Hepatology 77 4 (2022): 1319-1334. http://dx.doi.org/10.1002/hep.32756. 10.1002/hep.32756 Joana Lopes; Cecília M. P. Rodrigues; Maria Manuela Gaspar; Catarina Pinto Reis. "Melanoma Management: From Epidemiology to Treatment and Latest Advances". Cancers (2022): https://doi.org/10.3390/cancers14194652. 10.3390/cancers14194652 Joana Lopes; Cecília M. P. Rodrigues; Maria Manuela Gaspar; Catarina Pinto Reis. "How to Treat Melanoma? The Current Status of Innovative Nanotechnological Strategies and the Role of Minimally Invasive Approaches like PTT and PDT". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14091817. 10.3390/pharmaceutics14091817 Natália Aniceto; Vanda Marques; Joana D. Amaral; Patrícia A. Serra; Rui Moreira; Cecília M. P. Rodrigues; Rita C. Guedes. "Harnessing Protein-Ligand Interaction Fingerprints to Predict New Scaffolds of RIPK1 Inhibitors". Molecules (2022): https://doi.org/10.3390/molecules27154718. 10.3390/molecules27154718 Tawhidul Islam; Marta B. Afonso; Cecília M. P. Rodrigues. "The role of RIPK3 in liver mitochondria bioenergetics and function". European Journal of Clinical Investigation 52 3 (2022): https://doi.org/10.1111/eci.13648. 10.1111/eci.13648 Tânia Ferreira-Gonçalves; Maria Manuela Gaspar; João M. P. Coelho; Vanda Marques; Ana S. Viana; Lia Ascensão; Lina Carvalho; et al. "The Role of Rosmarinic Acid on the Bioproduction of Gold Nanoparticles as Part of a Photothermal Approach for Breast Cancer Treatment". Biomolecules (2022): https://www.mdpi.com/2218-273X/12/1/71. 10.3390/biom12010071 Alves, C.; Silva, J.; Afonso, M.B.; Guedes, R.A.; Guedes, R.C.; Alvariño, R.; Pinteus, S.; et al. "Disclosing the antitumour potential of the marine bromoditerpene sphaerococcenol A on distinct cancer cellular models". Biomedicine and Pharmacotherapy 149 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85127165182&partnerID=MN8TOARS. 10.1016/j.biopha.2022.112886 Magusto, J.; Beaupère, C.; Afonso, M.B.; Auclair, M.; Delaunay, J.-L.; Soret, P.-A.; Courtois, G.; et al. "The necroptosis-inducing pseudokinase mixed lineage kinase domain-like regulates the adipogenic differentiation of pre-adipocytes". iScience 25 10 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85139065321&partnerID=MN8TOARS. 10.1016/j.isci.2022.105166 Espadinha, M.; Lopes, E.A.; Marques, V.; Amaral, J.D.; dos Santos, D.J.V.A.; Mori, M.; Daniele, S.; et al. "Discovery of MDM2-p53 and MDM4-p53 protein-protein interactions small molecule dual inhibitors". European Journal of Medicinal Chemistry 241 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85135699740&partnerID=MN8TOARS. 10.1016/j.ejmech.2022.114637 Afonso, M.B.; Islam, T.; Magusto, J.; Amorim, R.; Lenoir, V.; F. Simões, R.; Teixeira, J.; et al. "RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease". Hepatology (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85139673348&partnerID=MN8TOARS. 10.1002/hep.32756 Condelipes, P.G.M.; Fontes, P.M.; Godinho-Santos, A.; Brás, E.J.S.; Marques, V.; Afonso, M.B.; Rodrigues, C.M.P.; et al. "Towards personalized antibody cancer therapy: development of a microfluidic cell culture device for antibody selection". Lab on a Chip 22 23 (2022): 4717-4728. http://www.scopus.com/inward/record.url?eid=2-s2.0-85142444651&partnerID=MN8TOARS. 10.1039/d2lc00918h Diana Alves; Sidónio Duarte; Pedro Arsénio; Joana Gonçalves; Rodrigues CMP; Ana Lourenço; Patrícia Máximo. "Exploring the Phytochemicals of Acacia melanoxylon R. Br.". Plants (2021): https://www.mdpi.com/2223-7747/10/12/2698. 10.3390/plants10122698 Sara Oliveira; Pedro A. Dionísio; Gaspar MM; Maria B. T. Ferreira; Catarina A. B. Rodrigues; Rita Pereira; Mónica S. Estevão; et al. "Discovery of a Necroptosis Inhibitor Improving Dopaminergic Neuronal Loss after MPTP Exposure in Mice". International Journal of Molecular Sciences (2021): https://www.mdpi.com/1422-0067/22/10/5289. 10.3390/ijms22105289 Jacinta O. Pinho; Inês V. da Silva; Joana D. Amaral; Cecília M.P. Rodrigues; Angela Casini; Graça Soveral; M. Manuela Gaspar. "Therapeutic potential of a copper complex loaded in pH-sensitive long circulating liposomes for colon cancer management". International Journal of Pharmaceutics 599 (2021): 120463-120463. https://doi.org/10.1016/j.ijpharm.2021.120463. 10.1016/j.ijpharm.2021.120463 Joana Lopes; Tânia Ferreira-Gonçalves; Isabel V. Figueiredo; Rodrigues CMP; Hugo Ferreira; David Alves Ferreira; Ana S. Viana; et al. "Proof-of-Concept Study of Multifunctional Hybrid Nanoparticle System Combined with NIR Laser Irradiation for the Treatment of Melanoma". Biomolecules (2021): https://www.mdpi.com/2218-273X/11/4/511. 10.3390/biom11040511 Rosa Couto; Constantino Coelho; Bassim Mounssef; Sara F. de A. Morais; Camila D. Lima; Wallans Torres Pio dos Santos; Félix Carvalho; et al. "3,4-Methylenedioxypyrovalerone (MDPV) Sensing Based on Electropolymerized Molecularly Imprinted Polymers on Silver Nanoparticles and Carboxylated Multi-Walled Carbon Nanotubes". Nanomaterials (2021): https://www.mdpi.com/2079-4991/11/2/353. 10.3390/nano11020353 Dionísio, PA; Amaral, JD; Rodrigues, CMP. "Oxidative stress and regulated cell death in Parkinson’s disease". Ageing Research Reviews (2021): 101263. http://dx.doi.org/10.1016/j.arr.2021.101263. Acesso aberto • Publicado • 10.1016/j.arr.2021.101263 Marin, J.J.G.; Prete, M.G.; Lamarca, A.; Tavolari, S.; Landa-Magdalena, A.; Brandi, G.; Segatto, O.; et al. "Correction: Current and novel therapeutic opportunities for systemic therapy in biliary cancer (British Journal of Cancer, (2020), 123, 7, (1047-1059), 10.1038/s41416-020-0987-3)". British Journal of Cancer 125 6 (2021): 904-904. http://www.scopus.com/inward/record.url?eid=2-s2.0-85110149465&partnerID=MN8TOARS. 10.1038/s41416-020-01243-3 Fernández-Tussy, P.; Rodríguez-Agudo, R.; Fernández-Ramos, D.; Barbier-Torres, L.; Zubiete-Franco, I.; Davalillo, S.L.; Herraez, E.; et al. "Anti-miR-518d-5p overcomes liver tumor cell death resistance through mitochondrial activity". Cell Death and Disease 12 6 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85107003939&partnerID=MN8TOARS. 10.1038/s41419-021-03827-0 Mózes, F.E.; Lee, J.A.; Selvaraj, E.A.; Jayaswal, A.N.A.; Trauner, M.; Boursier, J.; Fournier, C.; et al. "Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD: An individual patient data meta-analysis". Gut (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85106947127&partnerID=MN8TOARS. 10.1136/gutjnl-2021-324243 Selvaraj, E.A.; Mózes, F.E.; Jayaswal, A.N.A.; Zafarmand, M.H.; Vali, Y.; Lee, J.A.; Levick, C.K.; et al. "Diagnostic accuracy of elastography and magnetic resonance imaging in patients with NAFLD: A systematic review and meta-analysis". Journal of Hepatology 75 4 (2021): 770-785. http://www.scopus.com/inward/record.url?eid=2-s2.0-85108940286&partnerID=MN8TOARS. 10.1016/j.jhep.2021.04.044 Oliveira, S.R.; Dionísio, P.A.; Gaspar, M.M.; Correia Guedes, L.; Coelho, M.; Rosa, M.M.; Ferreira, J.J.; Amaral, J.D.; Rodrigues, C.M.P.. "miR-335 Targets LRRK2 and Mitigates Inflammation in Parkinson’s Disease". Frontiers in Cell and Developmental Biology 9 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85108989747&partnerID=MN8TOARS. 10.3389/fcell.2021.661461 Marques, V.; Afonso, M.B.; Bierig, N.; Duarte-Ramos, F.; Santos-Laso, Á.; Jimenez-Agüero, R.; Eizaguirre, E.; et al. "Adiponectin, Leptin, and IGF-1 Are Useful Diagnostic and Stratification Biomarkers of NAFLD". Frontiers in Medicine 8 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85109172986&partnerID=MN8TOARS. 10.3389/fmed.2021.683250 Mendes, M.O.; Rosa, A.I.; Carvalho, A.N.; Nunes, M.J.; Dionísio, P.; Rodrigues, E.; Costa, D.; et al. "Corrigendum to “Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy” [Mol. Cell. Neurosci., Volume 96, April 2019, Pages 1–9.] (Molecular and Cellular Neuroscience (2019) 96 (1–9), (S1044743118303907), (10.1016/j.mcn.2019.01.003))". Molecular and Cellular Neuroscience 114 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85105752069&partnerID=MN8TOARS. 10.1016/j.mcn.2021.103626 Afonso, Marta B; Rodrigues, Pedro M; Mateus-Pinheiro, Miguel; Simão, André L; Gaspar, Maria M; Majdi, Amine; Arretxe, Enara; et al. "RIPK3 acts as a lipid metabolism regulator contributing to inflammation and carcinogenesis in non-alcoholic fatty liver disease". Gut (2020): gutjnl-2020. http://dx.doi.org/10.1136/gutjnl-2020-321767. Acesso aberto • Publicado • 10.1136/gutjnl-2020-321767 Santos, André A.; Afonso, Marta B.; Ramiro, Ricardo S.; Pires, David; Pimentel, Madalena; Castro, Rui E.; Rodrigues, Cecília M.P.. "Host miRNA-21 promotes liver dysfunction by targeting small intestinal Lactobacillus in mice". Gut Microbes 12 1 (2020): 1840766. http://dx.doi.org/10.1080/19490976.2020.1840766. Publicado • 10.1080/19490976.2020.1840766 Ourô, Susana; Mourato, Cláudia; Velho, Sónia; Cardador, André; Ferreira, Marisa P.; Albergaria, Diogo; Castro, Rui E.; Maio, Rui; Rodrigues, Cecília M. P.. "Potential of miR-21 to Predict Incomplete Response to Chemoradiotherapy in Rectal Adenocarcinoma". Frontiers in Oncology 10 (2020): http://dx.doi.org/10.3389/fonc.2020.577653. Publicado • 10.3389/fonc.2020.577653 Susana Ourô; Cláudia Mourato; Marisa P. Ferreira; Diogo Albergaria; André Cardador; Rui E Castro; Rui Maio; Rodrigues CMP. "Evaluation of Tissue and Circulating miR-21 as Potential Biomarker of Response to Chemoradiotherapy in Rectal Cancer". Pharmaceuticals (2020): https://www.mdpi.com/1424-8247/13/9/246. 10.3390/ph13090246 Sara Oliveira; Pedro A. Dionísio; Leonor Correia Guedes; Nilza Gonçalves; Miguel Coelho; Mário M. Rosa; Joana D. Amaral; Joaquim J. Ferreira; Rodrigues CMP. "Circulating Inflammatory miRNAs Associated with Parkinson’s Disease Pathophysiology". Biomolecules (2020): https://www.mdpi.com/2218-273X/10/6/945. 10.3390/biom10060945 Tudor Mocan; André Simão; Rui E Castro; Rodrigues CMP; Artur Slomka; Bingduo Wang; Christian Strassburg; et al. "Liquid Biopsies in Hepatocellular Carcinoma: Are We Winning?". Journal of Clinical Medicine (2020): https://www.mdpi.com/2077-0383/9/5/1541. 10.3390/jcm9051541 Cotas, João; Marques, Vanda; Afonso, Marta B.; Rodrigues, Cecília M. P.; Pereira, Leonel. "Antitumour Potential of Gigartina pistillata Carrageenans against Colorectal Cancer Stem Cell-Enriched Tumourspheres". Marine Drugs 18 1 (2020): 50. http://dx.doi.org/10.3390/md18010050. 10.3390/md18010050 Balasubramanian, L.; Zuzarte-Luís, V.; Syed, T.; Mullick, D.; Deb, S.; Ranga-Prasad, H.; Meissner, J.; et al. "Association of Plasmodium berghei With the Apical Domain of Hepatocytes Is Necessary for the Parasite's Liver Stage Development". Frontiers in Cellular and Infection Microbiology 9 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078863463&partnerID=MN8TOARS. 10.3389/fcimb.2019.00451 Majdi, A.; Aoudjehane, L.; Ratziu, V.; Islam, T.; Afonso, M.B.; Conti, F.; Mestiri, T.; et al. "Inhibition of receptor-interacting protein kinase 1 improves experimental non-alcoholic fatty liver disease". Journal of Hepatology (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85078466129&partnerID=MN8TOARS. 10.1016/j.jhep.2019.11.008 Dionísio, P.A.; Amaral, J.D.; Rodrigues, C.M.P.. "Molecular mechanisms of necroptosis and relevance for neurodegenerative diseases". (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85079271604&partnerID=MN8TOARS. 10.1016/bs.ircmb.2019.12.006 Gautheron, Jérémie; Gores, Gregory J.; Rodrigues, Cecília M.P.. "Lytic cell death in metabolic liver disease". Journal of Hepatology 73 2 (2020): 394-408. http://dx.doi.org/10.1016/j.jhep.2020.04.001. Publicado • 10.1016/j.jhep.2020.04.001 Brito, H.; Marques, V.; Afonso, M.B.; Brown, D.G.; Börjesson, U.; Selmi, N.; Smith, D.M.; et al. "Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition". Cell Death Discovery 6 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85079729058&partnerID=MN8TOARS. Publicado • 10.1038/s41420-020-0240-0 Pereira, D.M.; Rodrigues, C.M.P.. "Targeted Avenues for Cancer Treatment: The MEK5–ERK5 Signaling Pathway". Trends in Molecular Medicine 26 (2020): 394-407. http://www.scopus.com/inward/record.url?eid=2-s2.0-85079379227&partnerID=MN8TOARS. Publicado • 10.1016/j.molmed.2020.01.006 Couto, Rosa A.S.; Mounssef, Bassim; Carvalho, Félix; Rodrigues, Cecília M.P.; Braga, Ataualpa A.C.; Aldous, Leigh; Gonçalves, Luís Moreira; Quinaz, M. Beatriz. "Methylone screening with electropolymerized molecularly imprinted polymer on screen-printed electrodes". Sensors and Actuators B: Chemical (2020): 128133. http://dx.doi.org/10.1016/j.snb.2020.128133. 10.1016/j.snb.2020.128133 Rodrigues, CMP; Fernandes, MB; Costa, M; Ribeiro, MF; Siquenique, S; Santos, SS; Martins, J; et al. "Reprograming of lipid metabolism as a new driving force behind tauroursodeoxycholic acid-induced neural stem cell proliferation". Frontiers Cell and Developmental Biology 8 335 (2020): Rodrigues, CMP; Mocan, T; Simão, AL; Castro, RE; Wang, B.; Wohler, A; Willms, A; Kornek, M. "Liquid biopsies in hepatocellular carcinoma: are we winning?". Journal of Clinical Medicine (2020): No prelo Rodrigues, CMP; Marín, J.J.G.; Prete, MG; Tavolari, S; Lamarca, A; Landa Magdalena, A; Bridgewater, J; et al. "Current and novel therapeutic opportunities in biliary cancer". British Journal of Cancer (2020): No prelo Ribeiro, Maria F; Santos, André A; Afonso, Marta B; Rodrigues, Pedro M; Sá Santos, Sónia; Castro, Rui E; Rodrigues, Cecília M P; Solá, Susana. "Diet-dependent gut microbiota impacts on adult neurogenesis through mitochondrial stress modulation". Brain Communications 2 2 (2020): http://dx.doi.org/10.1093/braincomms/fcaa165. Acesso aberto • Publicado • 10.1093/braincomms/fcaa165 Marin, J.J.G.; Prete, M.G.; Lamarca, A.; Tavolari, S.; Landa-Magdalena, A.; Brandi, G.; Segatto, O.; et al. "Current and novel therapeutic opportunities for systemic therapy in biliary cancer". British Journal of Cancer 123 7 (2020): 1047-1059. http://www.scopus.com/inward/record.url?eid=2-s2.0-85088295268&partnerID=MN8TOARS. 10.1038/s41416-020-0987-3 Fernandes, M.B.; Costa, M.; Ribeiro, M.F.; Siquenique, S.; Sá Santos, S.; Martins, J.; Coelho, A.V.; et al. "Reprogramming of Lipid Metabolism as a New Driving Force Behind Tauroursodeoxycholic Acid-Induced Neural Stem Cell Proliferation". Frontiers in Cell and Developmental Biology 8 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85086594829&partnerID=MN8TOARS. 10.3389/fcell.2020.00335 Hernández-Alvarez, M.I.; Sebastián, D.; Vives, S.; Ivanova, S.; Bartoccioni, P.; Kakimoto, P.; Plana, N.; et al. "Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease". Cell 177 4 (2019): 881-895.e17. http://www.scopus.com/inward/record.url?eid=2-s2.0-85064698279&partnerID=MN8TOARS. 10.1016/j.cell.2019.04.010 Oliveira, I.; Nunes, A.; Lima, A.; Borralho, P.; Rodrigues, C.; Ferreira, R.B.; Ribeiro, A.C.. "New lectins from mediterranean flora. Activity against ht29 colon cancer cells". International Journal of Molecular Sciences 20 12 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85068756845&partnerID=MN8TOARS. 10.3390/ijms20123059 Mendes, M.O.; Rosa, A.I.; Carvalho, A.N.; Nunes, M.J.; Dionísio, P.; Rodrigues, E.; Costa, D.; et al. "Neurotoxic effects of MPTP on mouse cerebral cortex: Modulation of neuroinflammation as a neuroprotective strategy". Molecular and Cellular Neuroscience 96 (2019): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062101670&partnerID=MN8TOARS. 10.1016/j.mcn.2019.01.003 Fouassier, L.; Marzioni, M.; Afonso, M.B.; Dooley, S.; Gaston, K.; Giannelli, G.; Rodrigues, C.M.P.; et al. "Signalling networks in cholangiocarcinoma: Molecular pathogenesis, targeted therapies and drug resistance". Liver International 39 S1 (2019): 43-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-85066016848&partnerID=MN8TOARS. 10.1111/liv.14102 Mendes, E.; Cadoni, E.; Carneiro, F.; Afonso, M.B.; Brito, H.; Lavrado, J.; dos Santos, D.J.V.A.; et al. "Combining 1,3-Ditriazolylbenzene and Quinoline to Discover a New G-Quadruplex-Interactive Small Molecule Active against Cancer Stem-Like Cells". ChemMedChem 14 14 (2019): 1325-1328. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067367035&partnerID=MN8TOARS. 10.1002/cmdc.201900243 Florindo, P.R.; Pereira, D.M.; Borralho, P.M.; Piedade, M.F.M.; Oliveira, M.C.; Dias, A.M.; Rodrigues, C.M.P.; Fernandes, A.C.. "Organoruthenium(ii) nucleoside conjugates as colon cytotoxic agents". New Journal of Chemistry 43 3 (2019): 1195-1201. http://www.scopus.com/inward/record.url?eid=2-s2.0-85060024038&partnerID=MN8TOARS. 10.1039/c8nj04515a Amaral, J.; Silva, D.; Rodrigues, C.M.; Solá, S.; Santos, M.M.. "Correction: A novel small molecule p53 stabilizer for brain cell differentiation [Front. Chem. 7, (2019) 15]doi: 10.3389/fchem.2019.00015". Frontiers in Chemistry 7 APR (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85064633645&partnerID=MN8TOARS. 10.3389/fchem.2019.00282 Amaral, J.D.; Silva, D.; Rodrigues, C.M.P.; Solá, S.; Santos, M.M.M.. "A novel small molecule p53 stabilizer for brain cell differentiation". Frontiers in Chemistry 7 JAN (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85061214972&partnerID=MN8TOARS. 10.3389/fchem.2019.00015 Couto, R.A.S.; Costa, S.S.; Mounssef, B.; Pacheco, J.G.; Fernandes, E.; Carvalho, F.; Rodrigues, C.M.P.; et al. "Electrochemical sensing of ecstasy with electropolymerized molecularly imprinted poly(o-phenylenediamine) polymer on the surface of disposable screen-printed carbon electrodes". Sensors and Actuators, B: Chemical 290 (2019): 378-386. http://www.scopus.com/inward/record.url?eid=2-s2.0-85064001772&partnerID=MN8TOARS. 10.1016/j.snb.2019.03.138 Santos-Rebelo, A.; Kumar, P.; Pillay, V.; Choonara, Y.E.; Eleutério, C.; Figueira, M.; Viana, A.S.; et al. "Development and mechanistic insight into the enhanced cytotoxic potential of parvifloron D albumin nanoparticles in EGFR-overexpressing pancreatic cancer cells". Cancers 11 11 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074759328&partnerID=MN8TOARS. 10.3390/cancers11111733 Dionísio, P.E.A.; Oliveira, S.R.; Amaral, J.S.J.D.; Rodrigues, C.M.P.. "Loss of Microglial Parkin Inhibits Necroptosis and Contributes to Neuroinflammation". Molecular Neurobiology 56 4 (2019): 2990-3004. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051233538&partnerID=MN8TOARS. 10.1007/s12035-018-1264-9 Pereira, D.M.; Gomes, S.E.; Borralho, P.M.; Rodrigues, C.M.P.. "MEK5/ERK5 activation regulates colon cancer stem-like cell properties". Cell Death Discovery 5 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071118850&partnerID=MN8TOARS. 10.1038/s41420-019-0150-1 Simão, A.L.; Afonso, M.B.; Rodrigues, P.M.; Gama-Carvalho, M.; Machado, M.V.; Cortez-Pinto, H.; Rodrigues, C.M.P.; Castro, R.E.. "Skeletal muscle miR-34a/SIRT1:AMPK axis is activated in experimental and human non-alcoholic steatohepatitis". Journal of Molecular Medicine 97 8 (2019): 1113-1126. http://www.scopus.com/inward/record.url?eid=2-s2.0-85066507444&partnerID=MN8TOARS. 10.1007/s00109-019-01796-8 Dionísio, P.A.; Oliveira, S.R.; Gaspar, M.M.; Gama, M.J.; Castro-Caldas, M.; Amaral, J.D.; Rodrigues, C.M.P.. "Ablation of RIP3 protects from dopaminergic neurodegeneration in experimental Parkinson’s disease". Cell Death and Disease 10 11 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85074563105&partnerID=MN8TOARS. 10.1038/s41419-019-2078-z Ribeiro, M.F.; Genebra, T.; Rego, A.C.; Rodrigues, C.M.P.; Solá, S.. "Amyloid ß Peptide Compromises Neural Stem Cell Fate by Irreversibly Disturbing Mitochondrial Oxidative State and Blocking Mitochondrial Biogenesis and Dynamics". Molecular Neurobiology 56 6 (2019): 3922-3936. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053603434&partnerID=MN8TOARS. 10.1007/s12035-018-1342-z Afonso, M.B.; Castro, R.E.; Rodrigues, C.M.P.. "Processes exacerbating apoptosis in non-alcoholic steatohepatitis". Clinical Science 133 22 (2019): 2245-2264. http://www.scopus.com/inward/record.url?eid=2-s2.0-85075206882&partnerID=MN8TOARS. 10.1042/CS20190068 Pinho, J.O.; Amaral, J.D.; Castro, R.E.; Rodrigues, C.M.P.; Casini, A.; Soveral, G.; Gaspar, M.M.. "Copper complex nanoformulations featuring highly promising therapeutic potential in murine melanoma models". Nanomedicine 14 7 (2019): 835-850. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063769714&partnerID=MN8TOARS. 10.2217/nnm-2018-0388 Afonso, M.B.; Rodrigues, P.M.; Simão, A.L.; Gaspar, M.M.; Carvalho, T.; Borralho, P.; Bañales, J.M.; Castro, R.E.; Rodrigues, C.M.P.. "MiRNA-21 ablation protects against liver injury and necroptosis in cholestasis". Cell Death and Differentiation 25 5 (2018): 857-872. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037678048&partnerID=MN8TOARS. 10.1038/s41418-017-0019-x Torres, J.; Palmela, C.; Gomes De Sena, P.; Santos, M.P.C.; Gouveia, C.; Oliveira, M.H.; Henriques, A.R.; et al. "Farnesoid X Receptor Expression in Microscopic Colitis: A Potential Role in Disease Etiopathogenesis". GE Portuguese Journal of Gastroenterology 25 1 (2018): 30-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-85031418668&partnerID=MN8TOARS. 10.1159/000481197 Mueller, M.; Castro, R.E.; Thorell, A.; Marschall, H.-U.; Auer, N.; Herac, M.; Rodrigues, C.M.P.; Trauner, M.. "Ursodeoxycholic acid: Effects on hepatic unfolded protein response, apoptosis and oxidative stress in morbidly obese patients". Liver International 38 3 (2018): 523-531. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030123543&partnerID=MN8TOARS. 10.1111/liv.13562 Soares, R.; Ribeiro, F.F.; Xapelli, S.; Genebra, T.; Ribeiro, M.F.; Sebastião, A.M.; Rodrigues, C.M.P.; Solá, S.. "Tauroursodeoxycholic Acid Enhances Mitochondrial Biogenesis, Neural Stem Cell Pool, and Early Neurogenesis in Adult Rats". Molecular Neurobiology 55 5 (2018): 3725-3738. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019966070&partnerID=MN8TOARS. 10.1007/s12035-017-0592-5 Augusto, T.V.; Georgina, C.-D.-S.; Rodrigues, C.M.P.; Teixeira, N.; Amaral, C.. "Acquired resistance to aromatase inhibitors: Where we stand!". Endocrine-Related Cancer 25 5 (2018): R283-R301. http://www.scopus.com/inward/record.url?eid=2-s2.0-85047336627&partnerID=MN8TOARS. 10.1530/ERC-17-0425 Afonso, M.B.; Rodrigues, C.M.P.. "MicroRevolution in understanding primary biliary cholangitis pathophysiology". Hepatology 67 4 (2018): 1213-1215. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044270541&partnerID=MN8TOARS. 10.1002/hep.29653 Couto, R.A.S.; Gonçalves, L.M.; Carvalho, F.; Rodrigues, J.A.; Rodrigues, C.M.P.; Quinaz, M.B.. "The Analytical Challenge in the Determination of Cathinones, Key-Players in the Worldwide Phenomenon of Novel Psychoactive Substances". Critical Reviews in Analytical Chemistry 48 5 (2018): 372-390. http://www.scopus.com/inward/record.url?eid=2-s2.0-85044210002&partnerID=MN8TOARS. 10.1080/10408347.2018.1439724 Dias, J.N.R.; Aguiar, S.I.; Pereira, D.M.; André, A.S.; Gano, L.; Correia, J.D.G.; Carrapiço, B.; et al. "The histone deacetylase inhibitor panobinostat is a potent antitumor agent in canine diffuse large B-cell lymphoma". Oncotarget 9 47 (2018): 28586-28598. http://www.scopus.com/inward/record.url?eid=2-s2.0-85048750657&partnerID=MN8TOARS. 10.18632/oncotarget.25580 Gomes, A.; da Silva, I.V.; Rodrigues, C.M.; Castro, R.E.; Soveral, G.. "The emerging role of microRNAs in aquaporin regulation". Frontiers in Chemistry 6 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85049204790&partnerID=MN8TOARS. 10.3389/fchem.2018.00238 Torres, J.; Palmela, C.; Brito, H.; Bao, X.; Ruiqi, H.; Moura-Santos, P.; Pereira da Silva, J.; et al. "The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease". United European Gastroenterology Journal 6 1 (2018): 112-122. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041113739&partnerID=MN8TOARS. 10.1177/2050640617708953 Gomes, S.E.; Pereira, D.M.; Roma-Rodrigues, C.; Fernandes, A.R.; Borralho, P.M.; Rodrigues, C.M.P.. "Convergence of MIR-143 overexpression, oxidative stress and cell death in HCT116 human colon cancer cells". PLoS ONE 13 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85040986423&partnerID=MN8TOARS. 10.1371/journal.pone.0191607 Rosa, A.I.; Duarte-Silva, S.; Silva-Fernandes, A.; Nunes, M.J.; Carvalho, A.N.; Rodrigues, E.; Gama, M.J.; et al. "Tauroursodeoxycholic Acid Improves Motor Symptoms in a Mouse Model of Parkinson’s Disease". Molecular Neurobiology (2018): 1-17. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045271175&partnerID=MN8TOARS. 10.1007/s12035-018-1062-4 Rodrigues, P.M.; Rodrigues, C.M.P.; Castro, R.E.. "Modulation of liver steatosis by miR-21/PPARa". Cell Death Discovery 4 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071006296&partnerID=MN8TOARS. 10.1038/s41420-018-0076-z Galluzzi, L.; Vitale, I.; Aaronson, S.A.; Abrams, J.M.; Adam, D.; Agostinis, P.; Alnemri, E.S.; et al. "Molecular mechanisms of cell death: Recommendations of the Nomenclature Committee on Cell Death 2018". Cell Death and Differentiation 25 3 (2018): 486-541. http://www.scopus.com/inward/record.url?eid=2-s2.0-85036533976&partnerID=MN8TOARS. 10.1038/s41418-017-0012-4 Cruz, S.; Gomes, S.E.; Borralho, P.M.; Rodrigues, C.M.P.; Gaudêncio, S.P.; Pereira, F.. "In silico HCT116 human colon cancer cell-based models en route to the discovery of lead-like anticancer drugs". Biomolecules 8 3 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85050362659&partnerID=MN8TOARS. 10.3390/biom8030056 Oliveira, S.R.; Amaral, J.D.; Rodrigues, C.M.P.. "Mechanism and disease implications of necroptosis and neuronal inflammation". Cell Death and Disease 9 9 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85052847266&partnerID=MN8TOARS. 10.1038/s41419-018-0872-7 Oliveira, S.R.; Dionísio, P.A.; Brito, H.; Franco, L.; Rodrigues, C.A.B.; Guedes, R.C.; Afonso, C.A.M.; Amaral, J.D.; Rodrigues, C.M.P.. "Phenotypic screening identifies a new oxazolone inhibitor of necroptosis and neuroinflammation". Cell Death Discovery 4 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85052872041&partnerID=MN8TOARS. 10.1038/s41420-018-0067-0 Mahmoudi, J.; Majdi, A.; Lattanzi, S.; Di Napoli, M.; Bershad, E.M.; Rodrigues, C.M.P.; Divani, A.A.. "Imidazoline receptor agonists for managing hypertension may hold promise for treatment of intracerebral hemorrhage". Current Molecular Medicine 18 4 (2018): 241-251. http://www.scopus.com/inward/record.url?eid=2-s2.0-85056503355&partnerID=MN8TOARS. 10.2174/1566524018666180926163712 Marques, C.C.; Santos-Silva, C.; Rodrigues, C.; Matos, J.E.; Moura, T.; Baptista, M.C.; Horta, A.E.M.; et al. "Bovine oocyte membrane permeability and cryosurvival: Effects of different cryoprotectants and calcium in the vitrification media". Cryobiology 81 (2018): 4-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043402900&partnerID=MN8TOARS. 10.1016/j.cryobiol.2018.03.003 Couto, R.A.S.; Gonçalves, L.M.; Góes, M.S.; Rodrigues, C.M.P.; Quinaz, M.B.; Rodrigues, J.A.. "SAM-based immunosensor for the analysis of thyroxine (T4)". Journal of the Electrochemical Society 164 4 (2017): B103-B106. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020671584&partnerID=MN8TOARS. 10.1149/2.0561704jes Rodrigues, P.M.; Afonso, M.B.; Simaõ, A.L.; Carvalho, C.C.; Trindade, A.; Duarte, A.; Borralho, P.M.; et al. "MiR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice". Cell Death and Disease 8 4 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85017474560&partnerID=MN8TOARS. 10.1038/cddis.2017.172 Nunes, R.C.; Ribeiro, C.J.A.; Monteiro, Â.; Rodrigues, C.M.P.; Amaral, J.D.; Santos, M.M.M.. "In vitro targeting of colon cancer cells using spiropyrazoline oxindoles". European Journal of Medicinal Chemistry 139 (2017): 168-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-85026814888&partnerID=MN8TOARS. 10.1016/j.ejmech.2017.07.057 Branco, V.; Coppo, L.; Solá, S.; Lu, J.; Rodrigues, C.M.P.; Holmgren, A.; Carvalho, C.. "Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury". Redox Biology 13 (2017): 278-287. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020255964&partnerID=MN8TOARS. 10.1016/j.redox.2017.05.024 Moreira, S.; Fonseca, I.; Nunes, M.J.; Rosa, A.; Lemos, L.; Rodrigues, E.; Carvalho, A.N.; et al. "Nrf2 activation by tauroursodeoxycholic acid in experimental models of Parkinson's disease". Experimental Neurology 295 (2017): 77-87. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020310862&partnerID=MN8TOARS. 10.1016/j.expneurol.2017.05.009 da Costa, M.; Bernardi, J.; Costa, L.; Fiuza, T.; Brandão, R.; Ribeiro, M.F.; Amaral, J.D.; Rodrigues, C.M.P.; Pereira, M.E.. "N-acetylcysteine treatment attenuates the cognitive impairment and synaptic plasticity loss induced by streptozotocin". Chemico-Biological Interactions 272 (2017): 37-46. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019180713&partnerID=MN8TOARS. 10.1016/j.cbi.2017.05.008 Fonseca, I.; Gordino, G.; Moreira, S.; Nunes, M.J.; Azevedo, C.; Gama, M.J.; Rodrigues, E.; Rodrigues, C.M.P.; Castro-Caldas, M.. "Erratum to: Tauroursodeoxycholic Acid Protects Against Mitochondrial Dysfunction and Cell Death via Mitophagy in Human Neuroblastoma Cells (Molecular Neurobiology, (2017), 54, 8, (6107-6119), 10.1007/s12035-016-0145-3)". Molecular Neurobiology 54 8 (2017): 6120-6120. http://www.scopus.com/inward/record.url?eid=2-s2.0-84992146179&partnerID=MN8TOARS. 10.1007/s12035-016-0228-1 Ribeiro, C.J.A.; Nunes, R.C.; Amaral, J.D.; Gonçalves, L.M.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties". European Journal of Medicinal Chemistry 140 (2017): 494-509. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030537870&partnerID=MN8TOARS. Publicado • 10.1016/j.ejmech.2017.09.037 Castro, R.E.; Rodrigues, C.M.P.. "Cell death and microRNAs in cholestatic liver diseases: Update on potential therapeutic applications". Current Drug Targets 18 8 (2017): 921-931. http://www.scopus.com/inward/record.url?eid=2-s2.0-85020402293&partnerID=MN8TOARS. 10.2174/1389450116666151019102358 Fonseca, I.; Gordino, G.; Moreira, S.; Nunes, M.J.; Azevedo, C.; Gama, M.J.; Rodrigues, E.; Rodrigues, C.M.P.; Castro-Caldas, M.. "Tauroursodeoxycholic Acid Protects Against Mitochondrial Dysfunction and Cell Death via Mitophagy in Human Neuroblastoma Cells". Molecular Neurobiology 54 8 (2017): 6107-6119. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989831585&partnerID=MN8TOARS. 10.1007/s12035-016-0145-3 Rosa, A.I.; Fonseca, I.; Nunes, M.J.; Moreira, S.; Rodrigues, E.; Carvalho, A.N.; Rodrigues, C.M.P.; Gama, M.J.; Castro-Caldas, M.. "Novel insights into the antioxidant role of tauroursodeoxycholic acid in experimental models of Parkinson's disease". Biochimica et Biophysica Acta - Molecular Basis of Disease 1863 9 (2017): 2171-2181. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021192126&partnerID=MN8TOARS. 10.1016/j.bbadis.2017.06.004 Santos, T.; Ferreira, R.; Quartin, E.; Boto, C.; Saraiva, C.; Bragança, J.; Peça, J.; et al. "Blue light potentiates neurogenesis induced by retinoic acid-loaded responsive nanoparticles". Acta Biomaterialia 59 (2017): 293-302. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021825481&partnerID=MN8TOARS. 10.1016/j.actbio.2017.06.044 Paterna, A.; Gomes, S.E.; Borralho, P.M.; Mulhovo, S.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "Vobasinyl-Iboga Alkaloids from Tabernaemontana elegans: Cell Cycle Arrest and Apoptosis-Inducing Activity in HCT116 Colon Cancer Cells". Journal of Natural Products 79 10 (2016): 2624-2634. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994056083&partnerID=MN8TOARS. 10.1021/acs.jnatprod.6b00552 Afonso, M.B.; Rodrigues, P.M.; Simão, A.L.; Ofengeim, D.; Carvalho, T.; Amaral, J.D.; Gaspar, M.M.; et al. "Activation of necroptosis in human and experimental cholestasis". Cell Death and Disease 7 9 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-85019011199&partnerID=MN8TOARS. 10.1038/cddis.2016.280 Gronbeck, K.R.; Rodrigues, C.M.P.; Mahmoudi, J.; Bershad, E.M.; Ling, G.; Bachour, S.P.; Divani, A.A.. "Application of Tauroursodeoxycholic Acid for Treatment of Neurological and Non-neurological Diseases: Is There a Potential for Treating Traumatic Brain Injury?". Neurocritical Care 25 1 (2016): 153-166. http://www.scopus.com/inward/record.url?eid=2-s2.0-84954324409&partnerID=MN8TOARS. 10.1007/s12028-015-0225-7 Prieto-Davï¿½, A.; Dias, T.; Gomes, S.E.; Rodrigues, S.; Parera-Valadez, Y.; Borralho, P.M.; Pereira, F.; et al. "The madeira archipelago as a significant source of marine-derived actinomycete diversity with anticancer and antimicrobial potential". Frontiers in Microbiology 7 OCT (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84996867996&partnerID=MN8TOARS. 10.3389/fmicb.2016.01594 Morgado, A.L.; Rodrigues, C.M.P.; Solá, S.. "MicroRNA-145 Regulates Neural Stem Cell Differentiation Through the Sox2-Lin28/let-7 Signaling Pathway". Stem Cells 34 5 (2016): 1386-1395. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964924272&partnerID=MN8TOARS. 10.1002/stem.2309 Rodrigues, C.M.P.; Moshage, H.. "Targeting TGR5 in cholangiocyte proliferation: Default topic". Gut 65 3 (2016): 369-370. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960316557&partnerID=MN8TOARS. 10.1136/gutjnl-2015-310812 Simões, A.E.S.; Rodrigues, C.M.P.; Borralho, P.M.. "The MEK5/ERK5 signalling pathway in cancer: a promising novel therapeutic target". Drug Discovery Today 21 10 (2016): 1654-1663. http://www.scopus.com/inward/record.url?eid=2-s2.0-84977590135&partnerID=MN8TOARS. 10.1016/j.drudis.2016.06.010 Paterna, A.; Gomes, S.E.; Borralho, P.M.; Mulhovo, S.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "(3'R)-hydroxytabernaelegantine C: A bisindole alkaloid with potent apoptosis inducing activity in colon (HCT116, SW620) and liver (HepG2) cancer cells". Journal of Ethnopharmacology 194 (2016): 236-244. http://www.scopus.com/inward/record.url?eid=2-s2.0-84987934442&partnerID=MN8TOARS. 10.1016/j.jep.2016.09.020 Moutinho, M.; Nunes, M.J.; Correia, J.C.; Gama, M.J.; Castro-Caldas, M.; Cedazo-Minguez, A.; Rodrigues, C.M.P.; et al. "Neuronal cholesterol metabolism increases dendritic outgrowth and synaptic markers via a concerted action of GGTase-I and Trk". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84981276916&partnerID=MN8TOARS. 10.1038/srep30928 Ribeiro, C.J.A.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Chemical variations on the p53 reactivation theme". Pharmaceuticals 9 2 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84973316044&partnerID=MN8TOARS. 10.3390/ph9020025 Nave, M.; Castro, R.E.; Rodrigues, C.M.P.; Casini, A.; Soveral, G.; Gaspar, M.M.. "Nanoformulations of a potent copper-based aquaporin inhibitor with cytotoxic effect against cancer cells". Nanomedicine 11 14 (2016): 1817-1830. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978525644&partnerID=MN8TOARS. 10.2217/nnm-2016-0086 Gomes, S.E.; Simões, A.E.S.; Pereira, D.M.; Castro, R.E.; Rodrigues, C.M.P.; Borralho, P.M.. "miR-143 or miR-145 overexpression increases cetuximab-mediated antibody-dependent cellular cytotoxicity in human colon cancer cells". Oncotarget 7 8 (2016): 9368-9387. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961590034&partnerID=MN8TOARS. 10.18632/oncotarget.7010 Pereira, D.M.; Simões, A.E.S.; Gomes, S.E.; Castro, R.E.; Carvalho, T.; Rodrigues, C.M.P.; Borralho, P.M.. "MEK5/ERK5 signaling inhibition increases colon cancer cell sensitivity to 5-fluorouracil through a p53-dependent mechanism". Oncotarget 7 23 (2016): 34322-34340. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973664372&partnerID=MN8TOARS. 10.18632/oncotarget.9107 Xavier, J.M.; Rodrigues, C.M.P.; Solá, S.. "Mitochondria: Major Regulators of Neural Development". Neuroscientist 22 4 (2016): 346-358. http://www.scopus.com/inward/record.url?eid=2-s2.0-84978997768&partnerID=MN8TOARS. 10.1177/1073858415585472 Florindo, Pedro R.; Pereira, Diane M.; Borralho, Pedro M.; Costa, Paulo J.; Piedade, M. F. M.; Rodrigues, Cecília M. P.; Fernandes, Ana C.. "New [(¿5-C5H5)Ru(N–N)(PPh3)][PF6] compounds: colon anticancer activity and GLUT-mediated cellular uptake of carbohydrate-appended complexes". Dalton Transactions 45 30 (2016): 11926-11930. http://dx.doi.org/10.1039/c6dt01571a. 10.1039/c6dt01571a Ribeiro, C.J.A.; Amaral, J.D.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Spirooxadiazoline oxindoles with promising in vitro antitumor activities". MedChemComm 7 3 (2016): 420-425. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961801651&partnerID=MN8TOARS. 10.1039/c5md00450k Rodrigues, P.M.; Afonso, M.B.; Simão, A.L.; Borralho, P.M.; Rodrigues, C.M.P.; Castro, R.E.. "Erratum: Inhibition of NF-kB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis (Scientific Reports (2016) 5 (17528) DOI: 10.1038/srep17528)". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84976303150&partnerID=MN8TOARS. 10.1038/srep27828 Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; et al. "Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356". Autophagy 12 2 (2016): 443-443. http://www.scopus.com/inward/record.url?eid=2-s2.0-84975859238&partnerID=MN8TOARS. 10.1080/15548627.2016.1147886 Klionsky, D.J.; Abdelmohsen, K.; Abe, A.; Abedin, M.J.; Abeliovich, H.; Arozena, A.A.; Adachi, H.; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)". Autophagy 12 1 (2016): 1-222. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013763791&partnerID=MN8TOARS. 10.1080/15548627.2015.1100356 Rodrigues, Cecília. "Ursodeoxycholic acid may slow progression of amyotrophic lateral sclerosis". Annals of Neurodegenerative Disorders 1 (2016): 1013. Sainz, V.; Peres, C.; Ciman, T.; Rodrigues, C.; Viana, A.S.; Afonso, C.A.M.; Barata, T.; et al. "Optimization of protein loaded PLGA nanoparticle manufacturing parameters following a quality-by-design approach". RSC Advances 6 106 (2016): 104502-104512. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994416030&partnerID=MN8TOARS. 10.1039/c6ra19092h Brito, H.; Martins, A.C.; Lavrado, J.; Mendes, E.; Francisco, A.P.; Santos, S.A.; Ohnmacht, S.A.; et al. "Targeting KRAS oncogene in colon cancer cells with 7-carboxylate Indolo[3,2-b] quinoline tri-alkylamine derivatives". PLoS ONE 10 5 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84934910595&partnerID=MN8TOARS. 10.1371/journal.pone.0126891 Afonso, M.B.; Rodrigues, P.M.; Carvalho, T.; Caridade, M.; Borralho, P.; Cortez-Pinto, H.; Castro, R.E.; Rodrigues, C.M.P.. "Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis". Clinical Science 129 8 (2015): 721-739. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942872734&partnerID=MN8TOARS. 10.1042/CS20140732 Galluzzi, L.; Bravo-San Pedro, J.M.; Vitale, I.; Aaronson, S.A.; Abrams, J.M.; Adam, D.; Alnemri, E.S.; et al. "Essential versus accessory aspects of cell death: Recommendations of the NCCD 2015". Cell Death and Differentiation 22 1 (2015): 58-73. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939986310&partnerID=MN8TOARS. 10.1038/cdd.2014.137 Morgado, A.L.; Xavier, J.M.; Dionísio, P.A.; Ribeiro, M.F.C.; Dias, R.B.; Sebastião, A.M.; Solá, S.; Rodrigues, C.M.P.. "MicroRNA-34a Modulates Neural Stem Cell Differentiation by Regulating Expression of Synaptic and Autophagic Proteins". Molecular Neurobiology 51 3 (2015): 1168-1183. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939874676&partnerID=MN8TOARS. 10.1007/s12035-014-8794-6 Moutinho, M.; Nunes, M.J.; Gomes, A.Q.; Gama, M.J.; Cedazo-Minguez, A.; Rodrigues, C.M.P.; Björkhem, I.; Rodrigues, E.. "Cholesterol 24S-Hydroxylase Overexpression Inhibits the Liver X Receptor (LXR) Pathway by Activating Small Guanosine Triphosphate-Binding Proteins (sGTPases) in Neuronal Cells". Molecular Neurobiology 51 3 (2015): 1489-1503. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939872953&partnerID=MN8TOARS. 10.1007/s12035-014-8828-0 Santos, L.A.; Solá, S.; Rodrigues, C.M.P.; Rebelo-de-Andrade, H.. "Distinct kinetics and pathways of apoptosis in influenza A and B virus infection". Virus Research 205 (2015): 33-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930857794&partnerID=MN8TOARS. 10.1016/j.virusres.2015.05.008 Sousa, T.; Castro, R.E.; Pinto, S.N.; Coutinho, A.; Lucas, S.D.; Moreira, R.; Rodrigues, C.M.P.; Prieto, M.; Fernandes, F.. "Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties". Journal of Lipid Research 56 11 (2015): 2158-2171. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948844490&partnerID=MN8TOARS. 10.1194/jlr.M062653 Florindo, P.R.; Pereira, D.M.; Borralho, P.M.; Rodrigues, C.M.P.; Piedade, M.F.M.; Fernandes, A.C.. "Cyclopentadienyl-ruthenium(II) and iron(II) organometallic compounds with carbohydrate derivative ligands as good colorectal anticancer agents". Journal of Medicinal Chemistry 58 10 (2015): 4339-4347. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930640155&partnerID=MN8TOARS. 10.1021/acs.jmedchem.5b00403 Lavrado, J.; Brito, H.; Borralho, P.M.; Ohnmacht, S.A.; Kim, N.-S.; Leitão, C.; Pisco, S.; et al. "KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines". Scientific Reports 5 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84927944758&partnerID=MN8TOARS. 10.1038/srep09696 Paterna, A.; Borralho, P.M.; Gomes, S.E.; Mulhovo, S.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "Monoterpene indole alkaloid hydrazone derivatives with apoptosis inducing activity in human HCT116 colon and HepG2 liver carcinoma cells". Bioorganic and Medicinal Chemistry Letters 25 17 (2015): 3556-3559. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938292387&partnerID=MN8TOARS. 10.1016/j.bmcl.2015.06.084 Dionísio, P.A.; Amaral, J.D.; Ribeiro, M.F.; Lo, A.C.; D'Hooge, R.; Rodrigues, C.M.P.. "Amyloid-ß pathology is attenuated by tauroursodeoxycholic acid treatment in APP/PS1 mice after disease onset". Neurobiology of Aging 36 1 (2015): 228-240. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920453379&partnerID=MN8TOARS. 10.1016/j.neurobiolaging.2014.08.034 Rodrigues, P.M.; Afonso, M.B.; Simaõ, A.L.; Borralho, P.M.; Rodrigues, C.M.P.; Castro, R.E.. "Inhibition of NF-kB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocelular apoptosis". Scientific Reports 5 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84949257807&partnerID=MN8TOARS. 10.1038/srep17528 Simões, A.; Pereira, D.M.; Gomes, S.E.; Brito, H.; Carvalho, T.; French, A.; Castro, R.E.; et al. "Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-kB activation". Cell Death and Disease 6 4 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84989924728&partnerID=MN8TOARS. 10.1038/cddis.2015.83 Ribeiro, C.J.A.; Amaral, J.D.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents". Bioorganic and Medicinal Chemistry 22 1 (2014): 577-584. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891490447&partnerID=MN8TOARS. 10.1016/j.bmc.2013.10.048 Xavier, J.M.; Morgado, A.L.; Rodrigues, C.M.P.; Solá, S.. "Tauroursodeoxycholic acid increases neural stem cell pool and neuronal conversion by regulating mitochondria-cell cycle retrograde signaling". Cell Cycle 13 22 (2014): 3576-3589. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920152844&partnerID=MN8TOARS. 10.4161/15384101.2014.962951 Xavier, J.M.; Morgado, A.L.; Solá, S.; Rodrigues, C.M.P.. "Mitochondrial translocation of p53 modulates neuronal fate by preventing differentiation-induced mitochondrial stress". Antioxidants and Redox Signaling 21 7 (2014): 1009-1024. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905661973&partnerID=MN8TOARS. 10.1089/ars.2013.5417 Ferreira, D.M.S.; Simão, A.L.; Rodrigues, C.M.P.; Castro, R.E.. "Revisiting the metabolic syndrome and paving the way for microRNAs in non-alcoholic fatty liver disease". FEBS Journal 281 11 (2014): 2503-2524. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901944989&partnerID=MN8TOARS. 10.1111/febs.12806 Luís, D.V.; Silva, J.; Tomaz, A.I.; De Almeida, R.F.M.; Larguinho, M.; Baptista, P.V.; Martins, L.M.D.R.S.; et al. "Insights into the mechanisms underlying the antiproliferative potential of a Co(II) coordination compound bearing 1,10-phenanthroline-5,6-dione: DNA and protein interaction studies". Journal of Biological Inorganic Chemistry 19 6 (2014): 787-803. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905814418&partnerID=MN8TOARS. 10.1007/s00775-014-1110-0 Ferreira, D.M.S.; Afonso, M.B.; Rodrigues, P.M.; Simão, A.L.; Pereira, D.M.; Borralho, P.M.; Rodrigues, C.M.P.; Castro, R.E.. "c-jun N-terminal kinase 1/c-jun activation of the p53/microRNA 34a/sirtuin 1 pathway contributes to apoptosis induced by deoxycholic acid in rat liver". Molecular and Cellular Biology 34 6 (2014): 1100-1120. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894244461&partnerID=MN8TOARS. 10.1128/MCB.00420-13 Mansoor, T.A.; Borralho, P.M.; Luo, X.; Mulhovo, S.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "6-Acetonyldihydrochelerythrine is a potent inducer of apoptosis in HCT116 and SW620 colon cancer cells". Journal of Natural Products 77 8 (2014): 1825-1830. http://www.scopus.com/inward/record.url?eid=2-s2.0-84906678560&partnerID=MN8TOARS. 10.1021/np500161n Borralho, P.M.; Rodrigues, C.M.P.; Steer, C.J.. "Mitochondrial MicroRNAs and Their Potential Role in Cell Function". Current Pathobiology Reports 2 3 (2014): 123-132. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940378400&partnerID=MN8TOARS. 10.1007/s40139-014-0047-x Diethmaier, C.; Newman, J.A.; Kovács, Á.T.; Kaever, V.; Herzberg, C.; Rodrigues, C.; Boonstra, M.; et al. "The YmdB phosphodiesterase is a global regulator of late adaptive responses in bacillus subtilis". Journal of Bacteriology 196 2 (2014): 265-275. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890926407&partnerID=MN8TOARS. 10.1128/JB.00826-13 Bugalho, A.; Ferreira, D.; Barata, R.; Rodrigues, C.; Dias, S.S.; Medeiros, F.; Carreiroa, E.L.. "Endobronchial ultrasound-guided transbronchial needle aspiration for lung cancer diagnosis and staging in 179 patients,Punção aspirativa transbrônquica guiada por ecoendoscopia brônquica no diagnóstico e estadiamento de cancro do pulmão em 179 doentes". Revista Portuguesa de Pneumologia 19 5 (2013): 192-199. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888151528&partnerID=MN8TOARS. 10.1016/j.rppnen.2013.10.005 Dosa, P.I.; Ward, T.; Castro, R.E.; Rodrigues, C.M.P.; Steer, C.J.. "Synthesis and Evaluation of Water-Soluble Prodrugs of Ursodeoxycholic Acid (UDCA), an Anti-apoptotic Bile Acid". ChemMedChem 8 6 (2013): 1002-1011. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878372256&partnerID=MN8TOARS. 10.1002/cmdc.201300059 Silva, A.; Luís, D.; Santos, S.; Silva, J.; Mendo, A.S.; Coito, L.; Silva, T.F.S.; et al. "Biological characterization of the antiproliferative potential of Co(II) and Sn(IV) coordination compounds in human cancer cell lines: A comparative proteomic approach". Drug Metabolism and Drug Interactions 28 3 (2013): 167-176. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888103842&partnerID=MN8TOARS. 10.1515/dmdi-2013-0015 Mansoor, T.A.; Borralho, P.M.; Luo, X.; Mulhovo, S.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "Apoptosis inducing activity of benzophenanthridine-type alkaloids and 2-arylbenzofuran neolignans in HCT116 colon carcinoma cells". Phytomedicine 20 10 (2013): 923-929. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879888690&partnerID=MN8TOARS. 10.1016/j.phymed.2013.03.026 Gaspar, J.M.; Martins, A.; Cruz, R.; Rodrigues, C.M.P.; Ambrósio, A.F.; Santiago, A.R.. "Tauroursodeoxycholic acid protects retinal neural cells from cell death induced by prolonged exposure to elevated glucose". Neuroscience 253 (2013): 380-389. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885227952&partnerID=MN8TOARS. 10.1016/j.neuroscience.2013.08.053 Simões, A.E.S.; Pereira, D.M.; Amaral, J.D.; Nunes, A.F.; Gomes, S.E.; Rodrigues, P.M.; Lo, A.C.; et al. "Efficient recovery of proteins from multiple source samples after trizol^®or trizol^®LS RNA extraction and long-term storage". BMC Genomics 14 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874944258&partnerID=MN8TOARS. 10.1186/1471-2164-14-181 Silva, T.F.S.; Smolenski, P.; Martins, L.M.D.R.S.; Guedes Da Silva, M.F.C.; Fernandes, A.R.; Luis, D.; Silva, A.; et al. "Cobalt and zinc compounds bearing 1,10-phenanthroline-5,6-dione or 1,3,5-triaza-7-phosphaadamantane derivatives - Synthesis, characterization, cytotoxicity, and cell selectivity studies". European Journal of Inorganic Chemistry 21 (2013): 3651-3658. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880155550&partnerID=MN8TOARS. 10.1002/ejic.201300197 Fonseca, M.B.; Solá, S.; Xavier, J.M.; Dionísio, P.A.; Rodrigues, C.M.P.. "Amyloid ß peptides promote autophagy-dependent differentiation of mouse neural stem cells: Aß-mediated neural differentiation". Molecular Neurobiology 48 3 (2013): 829-840. http://www.scopus.com/inward/record.url?eid=2-s2.0-84887988306&partnerID=MN8TOARS. 10.1007/s12035-013-8471-1 Ramalho, R.M.; Nunes, A.F.; Dias, R.B.; Amaral, J.D.; Lo, A.C.; D'Hooge, R.; Sebastião, A.M.; Rodrigues, C.M.P.. "Tauroursodeoxycholic acid suppresses amyloid ß-induced synaptic toxicity in vitro and in APP/PS1 mice". Neurobiology of Aging 34 2 (2013): 551-561. http://www.scopus.com/inward/record.url?eid=2-s2.0-84869091863&partnerID=MN8TOARS. 10.1016/j.neurobiolaging.2012.04.018 Amaral, J.D.; Herrera, F.; Rodrigues, P.M.; Dionísio, P.A.; Outeiro, T.F.; Rodrigues, C.M.P.. "Live-cell imaging of p53 interactions using a novel Venus-based bimolecular fluorescence complementation system". Biochemical Pharmacology 85 6 (2013): 745-752. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874114339&partnerID=MN8TOARS. 10.1016/j.bcp.2012.12.009 Pereira, D.M.; Rodrigues, P.M.; Borralho, P.M.; Rodrigues, C.M.P.. "Delivering the promise of miRNA cancer therapeutics". Drug Discovery Today 18 5-6 (2013): 282-289. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874722125&partnerID=MN8TOARS. 10.1016/j.drudis.2012.10.002 Lavrado, J.; Borralho, P.M.; Ohnmacht, S.A.; Castro, R.E.; Rodrigues, C.M.P.; Moreira, R.; Dos Santos, D.J.V.A.; Neidle, S.; Paulo, A.. "Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains". ChemMedChem 8 10 (2013): 1648-1661. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884950457&partnerID=MN8TOARS. 10.1002/cmdc.201300288 Castro, R.E.; Ferreira, D.M.S.; Afonso, M.B.; Borralho, P.M.; MacHado, M.V.; Cortez-Pinto, H.; Rodrigues, C.M.P.. "MiR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease". Journal of Hepatology 58 1 (2013): 119-125. http://www.scopus.com/inward/record.url?eid=2-s2.0-84871221881&partnerID=MN8TOARS. 10.1016/j.jhep.2012.08.008 Solá, S.; Morgado, A.L.; Rodrigues, C.M.P.. "Death receptors and mitochondria: Two prime triggers of neural apoptosis and differentiation". Biochimica et Biophysica Acta - General Subjects 1830 1 (2013): 2160-2166. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868246871&partnerID=MN8TOARS. 10.1016/j.bbagen.2012.09.021 Mello-Vieira, J.; Sousa, T.; Coutinho, A.; Fedorov, A.; Lucas, S.D.; Moreira, R.; Castro, R.E.; et al. "Cytotoxic bile acids, but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations". Biochimica et Biophysica Acta - Biomembranes 1828 9 (2013): 2152-2163. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879241584&partnerID=MN8TOARS. 10.1016/j.bbamem.2013.05.021 Pinton, S.; Sampaio, T.B.; Ramalho, R.M.; Rodrigues, C.M.P.; Nogueira, C.W.. "p,p^'-methoxyl-diphenyl diselenide prevents neurodegeneration and glial cell activation induced by streptozotocin in rats". Journal of Alzheimer's Disease 33 1 (2013): 133-144. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872464751&partnerID=MN8TOARS. 10.3233/JAD-2012-121150 Nunes, M.J.; Moutinho, M.; Gama, M.J.; Rodrigues, C.M.P.; Rodrigues, E.. "Histone Deacetylase Inhibition Decreases Cholesterol Levels in Neuronal Cells by Modulating Key Genes in Cholesterol Synthesis, Uptake and Efflux". PLoS ONE 8 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84872249052&partnerID=MN8TOARS. 10.1371/journal.pone.0053394 Newman, J.A.; Rodrigues, C.; Lewis, R.J.. "Molecular basis of the activity of SinR Protein, the master regulator of biofilm formation in bacillus subtilis". Journal of Biological Chemistry 288 15 (2013): 10766-10778. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876256819&partnerID=MN8TOARS. 10.1074/jbc.M113.455592 Mansoor, T.A.; Borralho, P.M.; Dewanjee, S.; Mulhovo, S.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "Monoterpene bisindole alkaloids, from the African medicinal plant Tabernaemontana elegans, induce apoptosis in HCT116 human colon carcinoma cells". Journal of Ethnopharmacology 149 2 (2013): 463-470. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883183604&partnerID=MN8TOARS. 10.1016/j.jep.2013.06.051 Santos, D.M.; Santos, M.M.M.; Moreira, R.; Solá, S.; Rodrigues, C.M.P.. "Synthetic condensed 1,4-naphthoquinone derivative shifts neural stem cell differentiation by regulating redox state". Molecular Neurobiology 47 1 (2013): 313-324. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872501397&partnerID=MN8TOARS. 10.1007/s12035-012-8353-y Lo, A.C.; Callaerts-Vegh, Z.; Nunes, A.F.; Rodrigues, C.M.P.; D'Hooge, R.. "Tauroursodeoxycholic acid (TUDCA) supplementation prevents cognitive impairment and amyloid deposition in APP/PS1 mice". Neurobiology of Disease 50 1 (2013): 21-29. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867741036&partnerID=MN8TOARS. 10.1016/j.nbd.2012.09.003 Santos, D.M.; Xavier, J.M.; Morgado, A.L.; Solá, S.; Rodrigues, C.M.P.. "Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation". PLoS ONE 7 3 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84858216332&partnerID=MN8TOARS. 10.1371/journal.pone.0033468 Newman, J.A.; Hewitt, L.; Rodrigues, C.; Solovyova, A.S.; Harwood, C.R.; Lewis, R.J.. "Dissection of the network of interactions that links RNA processing with glycolysis in the bacillus subtilis degradosome". Journal of Molecular Biology 416 1 (2012): 121-136. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856462779&partnerID=MN8TOARS. 10.1016/j.jmb.2011.12.024 Viana, R.J.S.; Nunes, A.F.; Rodrigues, C.M.P.. "Endoplasmic reticulum enrollment in Alzheimer's disease". Molecular Neurobiology 46 2 (2012): 522-534. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868154665&partnerID=MN8TOARS. 10.1007/s12035-012-8301-x Fonseca, M.B.; Nunes, A.F.; Morgado, A.L.; Solá, S.; Rodrigues, C.M.P.. "TAp63¿ Demethylation Regulates Protein Stability and Cellular Distribution during Neural Stem Cell Differentiation". PLoS ONE 7 12 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84871262127&partnerID=MN8TOARS. 10.1371/journal.pone.0052417 Gupta, S.; Li, S.; Abedin, M.J.; Noppakun, K.; Wang, L.; Kaur, T.; Najafian, B.; Rodrigues, C.M.P.; Steer, C.J.. "Prevention of Acute Kidney Injury by Tauroursodeoxycholic Acid in Rat and Cell Culture Models". PLoS ONE 7 11 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84869049949&partnerID=MN8TOARS. 10.1371/journal.pone.0048950 Castro-Caldas, M.; Carvalho, A.N.; Rodrigues, E.; Henderson, C.J.; Wolf, C.R.; Rodrigues, C.M.P.; Gama, M.J.. "Tauroursodeoxycholic acid prevents MPTP-induced dopaminergic cell death in a mouse model of Parkinson's disease". Molecular Neurobiology 46 2 (2012): 475-486. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868089556&partnerID=MN8TOARS. 10.1007/s12035-012-8295-4 Silva, T.F.S.; Martins, L.M.D.R.S.; Guedes Da Silva, M.F.C.; Fernandes, A.R.; Silva, A.; Borralho, P.M.; Santos, S.; Rodrigues, C.M.P.; Pombeiro, A.J.L.. "Cobalt complexes bearing scorpionate ligands: Synthesis, characterization, cytotoxicity and DNA cleavage". Dalton Transactions 41 41 (2012): 12888-12897. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867319657&partnerID=MN8TOARS. 10.1039/c2dt11577h Mansoor, T.A.; Ramalho, R.M.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "Dibenzylbutane- and butyrolactone-type lignans as apoptosis inducers in human hepatoma HuH-7 cells". Phytotherapy Research 26 5 (2012): 692-696. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859911852&partnerID=MN8TOARS. 10.1002/ptr.3629 Fonseca, M.B.; Nunes, A.F.; Rodrigues, C.M.P.. "C-Jun regulates the stability of anti-apoptotic ¿Np63 in amyloid-ß-induced apoptosis". Journal of Alzheimer's Disease 28 3 (2012): 685-694. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858016001&partnerID=MN8TOARS. 10.3233/JAD-2011-111547 Castro, R.E.; Rodrigues, C.M.P.. "Targeting miR-506 in primary biliary cirrhosis to support the HCO3^-umbrella". Clinics and Research in Hepatology and Gastroenterology 36 5 (2012): 402-404. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868354954&partnerID=MN8TOARS. 10.1016/j.clinre.2012.05.019 Nunes, A.F.; Amaral, J.D.; Lo, A.C.; Fonseca, M.B.; Viana, R.J.S.; Callaerts-Vegh, Z.; D'Hooge, R.; Rodrigues, C.M.P.. "TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-ß deposition in APP/PS1 mice". Molecular Neurobiology 45 3 (2012): 440-454. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867485621&partnerID=MN8TOARS. 10.1007/s12035-012-8256-y Solá, S.; Aranha, M.M.; Rodrigues, C.M.P.. "Driving apoptosis-relevant proteins toward neural differentiation". Molecular Neurobiology 46 2 (2012): 316-331. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868140124&partnerID=MN8TOARS. 10.1007/s12035-012-8289-2 Machado, M.V.; Ferreira, D.M.S.; Castro, R.E.; Silvestre, A.R.; Evangelista, T.; Coutinho, J.; Carepa, F.; et al. "Liver and muscle in morbid obesity: The interplay of fatty liver and insulin resistance". PLoS ONE 7 2 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84857127273&partnerID=MN8TOARS. 10.1371/journal.pone.0031738 Ferreira, D.M.S.; Castro, R.E.; MacHado, M.V.; Evangelista, T.; Silvestre, A.; Costa, A.; Coutinho, J.; et al. "Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease". Diabetologia 54 7 (2011): 1788-1798. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959755613&partnerID=MN8TOARS. 10.1007/s00125-011-2130-8 Newman, J.A.; Hewitt, L.; Rodrigues, C.; Solovyova, A.; Harwood, C.R.; Lewis, R.J.. "Unusual, dual endo- and exonuclease activity in the degradosome explained by crystal structure analysis of RNase J1". Structure 19 9 (2011): 1241-1251. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052458661&partnerID=MN8TOARS. 10.1016/j.str.2011.06.017 Solá, S.; Xavier, J.M.; Santos, D.M.; Aranha, M.M.; Morgado, A.L.; Jepsen, K.; Rodrigues, C.M.P.. "p53 interaction with JMJD3 results in its nuclear distribution during mouse neural stem cell differentiation". PLoS ONE 6 3 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79953666919&partnerID=MN8TOARS. 10.1371/journal.pone.0018421 Borralho, P.M.; Simões, A.E.S.; Gomes, S.E.; Lima, R.T.; Carvalho, T.; Ferreira, D.M.S.; Vasconcelos, M.H.; Castro, R.E.; Rodrigues, C.M.P.. "MiR-143 overexpression impairs growth of human colon carcinoma xenografts in mice with induction of apoptosis and inhibition of proliferation". PLoS ONE 6 8 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80052061782&partnerID=MN8TOARS. 10.1371/journal.pone.0023787 Lopes, P.A.; Martins, S.V.; Viana, R.S.J.; Ramalho, R.M.; Alfaia, C.M.; Pinho, M.S.; Jerónimo, E.; et al. "Contrasting apoptotic responses of conjugated linoleic acid in the liver of obese Zucker rats fed palm oil or ovine fat". Prostaglandins Leukotrienes and Essential Fatty Acids 85 2 (2011): 89-96. http://www.scopus.com/inward/record.url?eid=2-s2.0-79959619771&partnerID=MN8TOARS. 10.1016/j.plefa.2011.04.026 Mansoor, T.A.; Ramalho, R.M.; Luo, X.; Ramalhete, C.; Rodrigues, C.M.P.; Ferreira, M.-J.U.. "Isoflavones as apoptosis inducers in human hepatoma HuH-7 cells". Phytotherapy Research 25 12 (2011): 1819-1824. http://www.scopus.com/inward/record.url?eid=2-s2.0-82155183108&partnerID=MN8TOARS. 10.1002/ptr.3498 Viana, R.J.S.; Steer, C.J.; Rodrigues, C.M.P.. "Amyloid-ß peptide-induced secretion of endoplasmic reticulum chaperone glycoprotein GRP94". Journal of Alzheimer's Disease 27 1 (2011): 61-73. http://www.scopus.com/inward/record.url?eid=2-s2.0-80155190242&partnerID=MN8TOARS. 10.3233/JAD-2011-100395 Lehnik-Habrink, M.; Newman, J.; Rothe, F.M.; Solovyova, A.S.; Rodrigues, C.; Herzberg, C.; Commichau, F.M.; Lewis, R.J.; Stülke, J.. "RNase Y in Bacillus subtilis: A natively disordered protein that is the functional equivalent of RNase E from Escherichia coli". Journal of Bacteriology 193 19 (2011): 5431-5441. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053594659&partnerID=MN8TOARS. 10.1128/JB.05500-11 Parry, G.J.; Rodrigues, C.M.P.; Aranha, M.M.; Hilbert, S.J.; Davey, C.; Kelkar, P.; Low, W.C.; Steer, C.J.. "Safety, tolerability, and cerebrospinal fluid penetration of ursodeoxycholic acid in patients with amyotrophic lateral sclerosis". Clinical Neuropharmacology 33 1 (2010): 17-21. http://www.scopus.com/inward/record.url?eid=2-s2.0-76749123407&partnerID=MN8TOARS. 10.1097/WNF.0b013e3181c47569 Amaral, J.D.; Xavier, J.M.; Steer, C.J.; Rodrigues, C.M.. "The role of p53 in apoptosis.". Discovery medicine 9 45 (2010): 145-152. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952554792&partnerID=MN8TOARS. Aranha, M.M.; Santos, D.M.; Xavier, J.M.; Low, W.C.; Steer, C.J.; Solá, S.; Rodrigues, C.M.P.. "Apoptosis-associated microRNAs are modulated in mouse, rat and human neural differentiation". BMC Genomics 11 1 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956937548&partnerID=MN8TOARS. 10.1186/1471-2164-11-514 Amaral, J.D.; Xavier, J.M.; Steer, C.J.; Rodrigues, C.M.P.. "Targeting the p53 pathway of apoptosis". Current Pharmaceutical Design 16 22 (2010): 2493-2503. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955630266&partnerID=MN8TOARS. 10.2174/138161210791959818 Amaral, J.D.; Castro, R.E.; Solá, S.; Steer, C.J.; Rodrigues, C.M.P.. "Ursodeoxycholic acid modulates the ubiquitin-proteasome degradation pathway of p53". Biochemical and Biophysical Research Communications 400 4 (2010): 649-654. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957258575&partnerID=MN8TOARS. 10.1016/j.bbrc.2010.08.121 Amaral, J.D.; Correia, A.R.; Steer, C.J.; Gomes, C.M.; Rodrigues, C.M.P.. "No evidence of direct binding between ursodeoxycholic acid and the p53 DNA-binding domain". Bioscience Reports 30 5 (2010): 359-364. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954733196&partnerID=MN8TOARS. 10.1042/BSR20090107 Castro, R.E.; Santos, M.M.M.; Glória, P.M.C.; Ribeiro, C.J.A.; Ferreira, D.M.S.; Xavier, J.M.; Moreira, R.; Rodrigues, C.M.P.. "Cell death targets and potential modulators in alzheimer's disease". Current Pharmaceutical Design 16 25 (2010): 2851-2864. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957958533&partnerID=MN8TOARS. Castro, R.E.; Ferreira, D.M.S.; Zhang, X.; Borralho, P.M.; Sarver, A.L.; Zeng, Y.; Steer, C.J.; Kren, B.T.; Rodrigues, C.M.P.. "Identification of microRNAs during rat liver regeneration after partial hepatectomy and modulation by ursodeoxycholic acid". American Journal of Physiology - Gastrointestinal and Liver Physiology 299 4 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77957350904&partnerID=MN8TOARS. 10.1152/ajpgi.00216.2010 Viana, R.J.S.; Fonseca, M.B.; Ramalho, R.M.; Nunes, A.F.; Rodrigues, C.M.P.. "Organelle stress sensors and cell death mechanisms in neurodegenerative diseases". CNS and Neurological Disorders - Drug Targets 9 6 (2010): 679-692. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649287483&partnerID=MN8TOARS. Gunka, K.; Newman, J.A.; Commichau, F.M.; Herzberg, C.; Rodrigues, C.; Hewitt, L.; Lewis, R.J.; Stülke, J.. "Functional dissection of a trigger enzyme: Mutations of the bacillus subtilis glutamate dehydrogenase RocG that affect differentially its catalytic activity and regulatory properties". Journal of Molecular Biology 400 4 (2010): 815-827. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954383542&partnerID=MN8TOARS. 10.1016/j.jmb.2010.05.055 Viana, R.J.S.; Ramalho, R.M.; Nunes, A.F.; Steer, C.J.; Rodrigues, C.M.P.. "Modulation of amyloid-ß peptide-induced toxicity through inhibition of JNK nuclear localization and caspase-2 activation". Journal of Alzheimer's Disease 22 2 (2010): 557-568. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650814490&partnerID=MN8TOARS. 10.3233/JAD-2010-100909 Ravasco, P.; Aranha, M.M.; Borralho, P.M.; Moreira da Silva, I.B.; Correia, L.; Fernandes, A.; Rodrigues, C.M.P.; Camilo, M.. "Colorectal cancer: Can nutrients modulate NF-¿B and apoptosis?". Clinical Nutrition 29 1 (2010): 42-46. http://www.scopus.com/inward/record.url?eid=2-s2.0-75949095938&partnerID=MN8TOARS. 10.1016/j.clnu.2009.06.006 Santos, D.M.; Santos, M.M.M.; Viana, R.J.S.; Castro, R.E.; Moreira, R.; Rodrigues, C.M.P.. "Naphtho[2,3-d]isoxazole-4,9-dione-3-carboxylates: Potent, non-cytotoxic, antiapoptotic agents". Chemico-Biological Interactions 180 2 (2009): 175-182. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349174541&partnerID=MN8TOARS. 10.1016/j.cbi.2009.03.007 Borralho, P.M.; Kren, B.T.; Castro, R.E.; Moreira Da Silva, I.B.; Steer, C.J.; Rodrigues, C.M.P.. "MicroRNA-143 reduces viability and increases sensitivity to 5-fluorouracil in HCT116 human colorectal cancer cells". FEBS Journal 276 22 (2009): 6689-6700. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350433121&partnerID=MN8TOARS. 10.1111/j.1742-4658.2009.07383.x Amaral, J.D.; Castro, R.E.; Steer, C.J.; Rodrigues, C.M.P.. "p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis". Trends in Molecular Medicine 15 11 (2009): 531-541. http://www.scopus.com/inward/record.url?eid=2-s2.0-70449109071&partnerID=MN8TOARS. 10.1016/j.molmed.2009.09.005 Sarver, A.L.; French, A.J.; Borralho, P.M.; Thayanithy, V.; Oberg, A.L.; Silverstein, K.A.T.; Morlan, B.W.; et al. "Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states". BMC Cancer 9 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-71549125896&partnerID=MN8TOARS. 10.1186/1471-2407-9-401 Amaral, J.D.; Viana, R.J.S.; Ramalho, R.M.; Steer, C.J.; Rodrigues, C.M.P.. "Bile acids: Regulation of apoptosis by ursodeoxycholic acid". Journal of Lipid Research 50 9 (2009): 1721-1734. http://www.scopus.com/inward/record.url?eid=2-s2.0-70350417325&partnerID=MN8TOARS. 10.1194/jlr.R900011-JLR200 Amaral, J.D.; Solá, S.; Steer, C.J.; Rodrigues, C.M.P.. "Role of nuclear steroid receptors in apoptosis". Current Medicinal Chemistry 16 29 (2009): 3886-3902. http://www.scopus.com/inward/record.url?eid=2-s2.0-70450193159&partnerID=MN8TOARS. 10.2174/092986709789178028 Aranha, M.M.; Solá, S.; Low, W.C.; Steer, C.J.; Rodrigues, C.M.P.. "Caspases and p53 modulate FOXO3A/Id1 signaling during mouse neural stem cell differentiation". Journal of Cellular Biochemistry 107 4 (2009): 748-758. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650084412&partnerID=MN8TOARS. 10.1002/jcb.22172 Galluzzi, L.; Aaronson, S.A.; Abrams, J.; Alnemri, E.S.; Andrews, D.W.; Baehrecke, E.H.; Bazan, N.G.; et al. "Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes". Cell Death and Differentiation 16 8 (2009): 1093-1107. http://www.scopus.com/inward/record.url?eid=2-s2.0-67650751080&partnerID=MN8TOARS. 10.1038/cdd.2009.44 Mansoor, T.A.; Ramalho, R.M.; Mulhovo, S.; Rodrigues, C.M.P.; Ferreira, M.J.U.. "Induction of apoptosis in HuH-7 cancer cells by monoterpene and ß-carboline indole alkaloids isolated from the leaves of Tabernaemontana elegans". Bioorganic and Medicinal Chemistry Letters 19 15 (2009): 4255-4258. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649949958&partnerID=MN8TOARS. 10.1016/j.bmcl.2009.05.104 Viana, R.J.S.; Nunes, A.F.; Castro, R.E.; Ramalho, R.M.; Meyerson, J.; Fossati, S.; Ghiso, J.; Rostagno, A.; Rodrigues, C.M.P.. "Tauroursodeoxycholic acid prevents E22Q Alzheimer's Aß toxicity in human cerebral endothelial cells". Cellular and Molecular Life Sciences 66 6 (2009): 1094-1104. http://www.scopus.com/inward/record.url?eid=2-s2.0-62349110126&partnerID=MN8TOARS. 10.1007/s00018-009-8746-x Ramalho, R.M.; Viana, R.J.S.; Low, W.C.; Steer, C.J.; Rodrigues, C.M.P.. "Bile acids and apoptosis modulation: an emerging role in experimental Alzheimer's disease". Trends in Molecular Medicine 14 2 (2008): 54-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-39149099114&partnerID=MN8TOARS. 10.1016/j.molmed.2007.12.001 Ramalho, R.M.; Viana, R.J.S.; Castro, R.E.; Steer, C.J.; Low, W.C.; Rodrigues, C.M.P.. "Apoptosis in transgenic mice expressing the P301L mutated form of human tau". Molecular Medicine 14 5-6 (2008): 309-317. http://www.scopus.com/inward/record.url?eid=2-s2.0-44649156233&partnerID=MN8TOARS. 10.2119/2007-00133.Ramalho Aranha, M.M.; Cortez-Pinto, H.; Costa, A.; Da Silva, I.B.M.; Camilo, M.E.; De Moura, M.C.; Rodrigues, C.M.P.. "Bile acid levels are increased in the liver of patients with steatohepatitis". European Journal of Gastroenterology and Hepatology 20 6 (2008): 519-525. http://www.scopus.com/inward/record.url?eid=2-s2.0-43449094989&partnerID=MN8TOARS. 10.1097/MEG.0b013e3282f4710a Castro, R.E.; Solá, S.; Steer, C.J.; Rodrigues, C.M.P.. "Bile Acids as Modulators of Apoptosis". Hepatotoxicity: From Genomics to in vitro and in vivo Models (2008): 391-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-84889333062&partnerID=MN8TOARS. 10.1002/9780470516751.ch15 Ferreira-Dias, G.; Mateus, L.; Costa, A.S.; Solá, S.; Ramalho, R.M.; Castro, R.E.; Rodrigues, C.M.P.. "Progesterone and caspase-3 activation in equine cyclic corpora lutea". Reproduction in Domestic Animals 42 4 (2007): 380-386. http://www.scopus.com/inward/record.url?eid=2-s2.0-34447251468&partnerID=MN8TOARS. 10.1111/j.1439-0531.2006.00795.x Rivard, A.L.; Steer, C.J.; Kren, B.T.; Rodrigues, C.M.P.; Castro, R.E.; Bianco, R.W.; Low, W.C.. "Administration of Tauroursodeoxycholic Acid (TUDCA) reduces apoptosis following myocardial infarction in rat". American Journal of Chinese Medicine 35 2 (2007): 279-295. http://www.scopus.com/inward/record.url?eid=2-s2.0-34147220621&partnerID=MN8TOARS. 10.1142/S0192415X07004813 Borralho, P.M.; Moreira da Silva, I.B.; Aranha, M.M.; Albuquerque, C.; Nobre Leitão, C.; Steer, C.J.; Rodrigues, C.M.P.. "Inhibition of Fas expression by RNAi modulates 5-fluorouracil-induced apoptosis in HCT116 cells expressing wild-type p53". Biochimica et Biophysica Acta - Molecular Basis of Disease 1772 1 (2007): 40-47. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845626186&partnerID=MN8TOARS. 10.1016/j.bbadis.2006.09.005 Aranha, M.M.; Matos, A.R.; Teresa Mendes, A.; Vaz Pinto, V.; Rodrigues, C.M.P.; Arrabaça, J.D.. "Dinitro-o-cresol induces apoptosis-like cell death but not alternative oxidase expression in soybean cells". Journal of Plant Physiology 164 6 (2007): 675-684. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247847605&partnerID=MN8TOARS. 10.1016/j.jplph.2006.09.010 Aranha, M.M.; Borralho, P.M.; Ravasco, P.; Moreira Da Silva, I.B.; Correia, L.; Fernandes, A.; Camilo, M.E.; Rodrigues, C.M.P.. "NF-¿B and apoptosis in colorectal tumourigenesis". European Journal of Clinical Investigation 37 5 (2007): 416-424. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247496831&partnerID=MN8TOARS. 10.1111/j.1365-2362.2007.01801.x Castro, R.E.; Amaral, J.D.; Solá, S.; Kren, B.T.; Steer, C.J.; Rodrigues, C.M.P.. "Differential regulation of cyclin D1 and cell death by bile acids in primary rat hepatocytes". American Journal of Physiology - Gastrointestinal and Liver Physiology 293 1 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-34547109141&partnerID=MN8TOARS. 10.1152/ajpgi.00093.2007 Solá, S.; Aranha, M.M.; Steer, C.J.; Rodrigues, C.M.P.. "Game and players: Mitochondrial apoptosis and the therapeutic potential of ursodeoxycholic acid". Current Issues in Molecular Biology 9 2 (2007): 123-138. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247181117&partnerID=MN8TOARS. Amaral, J.D.; Castro, R.E.; Solá, S.; Steer, C.J.; Rodrigues, C.M.P.. "p53 is a key molecular target of ursodeoxycholic acid in regulating apoptosis". Journal of Biological Chemistry 282 47 (2007): 34250-34259. http://www.scopus.com/inward/record.url?eid=2-s2.0-36348941176&partnerID=MN8TOARS. 10.1074/jbc.M704075200 Amaral, J.D.; Solá, S.; Steer, C.J.; Rodrigues, C.P.. "Function of nuclear steroid receptors in apoptosis: Role of ursodeoxycholic acid". Expert Review of Endocrinology and Metabolism 2 4 (2007): 487-501. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547549183&partnerID=MN8TOARS. 10.1586/17446651.2.4.487 Zhang, W.; Steer, C.J.; Douglas, K.T.; Rodrigues, C.M.P.. "Binding studies of bile acids using the native fluorescence of the tryptophan residue of bax protein". Bioscience Reports 26 3 (2006): 245-250. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747464019&partnerID=MN8TOARS. 10.1007/s10540-006-9019-7 Ramalho, R.M.; Cortez-Pinto, H.; Castro, R.E.; Solá, S.; Costa, A.; Moura, M.C.; Camilo, M.E.; Rodrigues, C.M.P.. "Apoptosis and Bcl-2 expression in the livers of patients with steatohepatitis". European Journal of Gastroenterology and Hepatology 18 1 (2006): 21-29. http://www.scopus.com/inward/record.url?eid=2-s2.0-29344441053&partnerID=MN8TOARS. 10.1097/00042737-200601000-00005 Steer, C.; Rodrigues, C.M.P.. "Fooling the Fas ligand in death". Hepatology 44 2 (2006): 314-317. http://www.scopus.com/inward/record.url?eid=2-s2.0-33747064112&partnerID=MN8TOARS. 10.1002/hep.21320 Solá, S.; Garshelis, D.L.; Amaral, J.D.; Noyce, K.V.; Coy, P.L.; Steer, C.J.; Iaizzo, P.A.; Rodrigues, C.M.P.. "Plasma levels of ursodeoxycholic acid in black bears, Ursus americanus: Seasonal changes". Comparative Biochemistry and Physiology - C Toxicology and Pharmacology 143 2 (2006): 204-208. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646196447&partnerID=MN8TOARS. 10.1016/j.cbpc.2006.02.002 Solá, S.; Amaral, J.D.; Aranha, M.M.; Steer, C.J.; Rodrigues, C.M.P.. "Modulation of hepatocyte apoptosis: Cross-talk between bile acids and nuclear steroid receptors". Current Medicinal Chemistry 13 25 (2006): 3039-3051. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749433408&partnerID=MN8TOARS. 10.2174/092986706778521823 Ramalho, R.M.; Borralho, P.M.; Castro, R.E.; Solá, S.; Steer, C.J.; Rodrigues, C.M.P.. "Tauroursodeoxycholic acid modulates p53-mediated apoptosis in Alzheimer's disease mutant neuroblastoma cells". Journal of Neurochemistry 98 5 (2006): 1610-1618. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746862168&partnerID=MN8TOARS. 10.1111/j.1471-4159.2006.04007.x Boatright, J.H.; Moring, A.G.; McElroy, C.; Phillips, M.J.; Do, V.T.; Chang, B.; Hawes, N.L.; et al. "Tool from ancient pharmacopoeia prevents vision loss". Molecular Vision 12 (2006): 1706-1714. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846145693&partnerID=MN8TOARS. Solá, S.; Amaral, J.D.; Borralho, P.M.; Ramalho, R.M.; Castro, R.E.; Aranha, M.M.; Steer, C.J.; Rodrigues, C.M.P.. "Functional modulation of nuclear steroid receptors by tauroursodeoxycholic acid reduces amyloid ß-peptide-induced apoptosis". Molecular Endocrinology 20 10 (2006): 2292-2303. http://www.scopus.com/inward/record.url?eid=2-s2.0-33749332011&partnerID=MN8TOARS. 10.1210/me.2006-0063 Castro, R.E.; Solá, S.; Ma, X.; Ramalho, R.M.; Kren, B.T.; Steer, C.J.; Rodrigues, C.M.P.. "A distinct microarray gene expression profile in primary rat hepatocytes incubated with ursodeoxycholic acid". Journal of Hepatology 42 6 (2005): 897-906. http://www.scopus.com/inward/record.url?eid=2-s2.0-18844397275&partnerID=MN8TOARS. 10.1016/j.jhep.2005.01.026 Wachs, F.-P.; Krieg, R.C.; Rodrigues, C.M.P.; Messmann, H.; Kullmann, F.; Knüchel-Clarke, R.; Schölmerich, J.; Rogler, G.; Schlottmann, K.. "Bile salt-induced apoptosis in human colon cancer cell lines involves the mitochondrial transmembrane potential but not the CD95 (Fas/Apo-1) receptor". International Journal of Colorectal Disease 20 2 (2005): 103-113. http://www.scopus.com/inward/record.url?eid=2-s2.0-13644249778&partnerID=MN8TOARS. 10.1007/s00384-004-0616-2 Ved, R.; Saha, S.; Westlund, B.; Perier, C.; Burnam, L.; Sluder, A.; Hoener, M.; et al. "Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of a-synuclein, parkin, and DJ-1 in Caenorhabditis elegans". Journal of Biological Chemistry 280 52 (2005): 42655-42668. http://www.scopus.com/inward/record.url?eid=2-s2.0-30044434872&partnerID=MN8TOARS. 10.1074/jbc.M505910200 Solá, S.; Amaral, J.D.; Castro, R.E.; Ramalho, R.M.; Borralho, P.M.; Kren, B.T.; Tanaka, H.; Steer, C.J.; Rodrigues, C.M.P.. "Nuclear translocation of UDCA by the glucocorticoid receptor is required to reduce TGF-ß1-induced apoptosis in rat hepatocytes". Hepatology 42 4 (2005): 925-934. http://www.scopus.com/inward/record.url?eid=2-s2.0-25844516609&partnerID=MN8TOARS. 10.1002/hep.20870 Ribeiro, P.S.; Cortez-Pinto, H.; Solá, S.; Castro, R.E.; Ramalho, R.M.; Baptista, A.; Moura, M.C.; Camilo, M.E.; Rodrigues, C.M.P.. "Hepatocyte apoptosis, expression of death receptors, and activation of NF-¿B in the liver of nonalcoholic and alcoholic steatohepatitis patients". American Journal of Gastroenterology 99 9 (2004): 1708-1717. http://www.scopus.com/inward/record.url?eid=2-s2.0-4544335155&partnerID=MN8TOARS. 10.1111/j.1572-0241.2004.40009.x Castro, R.E.; Solá, S.; Ramalho, R.M.; Steer, C.J.; Rodrigues, C.M.P.. "The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of Bad via phosphatidylinositol 3-kinase in glutamate-induced apoptosis of rat cortical neurons". Journal of Pharmacology and Experimental Therapeutics 311 2 (2004): 845-852. http://www.scopus.com/inward/record.url?eid=2-s2.0-6344279913&partnerID=MN8TOARS. 10.1124/jpet.104.070532 Solá, S.; Castro, R.E.; Kren, B.T.; Steer, C.J.; Rodrigues, C.M.P.. "Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-ß1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes". Biochemistry 43 26 (2004): 8429-8438. http://www.scopus.com/inward/record.url?eid=2-s2.0-3142580336&partnerID=MN8TOARS. 10.1021/bi049781x Fan, G.; Ma, X.; Wong, P.Y.; Rodrigues, C.M.P.; Steer, C.J.. "p53 dephosphorylation and p21Cip1/Waf1 translocation correlate with caspase-3 activation in TGF-ß1-induced apoptosis of HuH-7 cells". Apoptosis 9 2 (2004): 211-221. http://www.scopus.com/inward/record.url?eid=2-s2.0-3342982324&partnerID=MN8TOARS. 10.1023/B:APPT.0000018803.11260.02 Ramalho, R.M.; Ribeiro, P.S.; Solá, S.; Castro, R.E.; Steer, C.J.; Rodrigues, C.M.P.. "Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid ß-peptide-induced apoptosis of PC12 cells". Journal of Neurochemistry 90 3 (2004): 567-575. http://www.scopus.com/inward/record.url?eid=2-s2.0-3342885971&partnerID=MN8TOARS. 10.1111/j.1471-4159.2004.02517.x Solá, S.; Castro, R.E.; Laires, P.A.; Steer, C.J.; Rodrigues, C.M.P.. "Tauroursodeoxycholic acid prevents amyloid-ß peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway". Molecular Medicine 9 9-12 (2003): 226-234. http://www.scopus.com/inward/record.url?eid=2-s2.0-3042698849&partnerID=MN8TOARS. Rodrigues, C.M.P.; Solá, S.; Sharpe, J.C.; Moura, J.J.G.; Steer, C.J.. "Tauroursodeoxycholic acid prevents Bax-induced membrane perturbation and cytochrome c release in isolated mitochondria". Biochemistry 42 10 (2003): 3070-3080. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037452957&partnerID=MN8TOARS. 10.1021/bi026979d Rodrigues, C.M.P.; Solá, S.; Nan, Z.; Castro, R.E.; Ribeiro, P.S.; Low, W.C.; Steer, C.J.. "Tauroursodeoxycholic acid reduces apoptosis and protects against neurological injury after acute hemorrhagic stroke in rats". Proceedings of the National Academy of Sciences of the United States of America 100 10 (2003): 6087-6092. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038623782&partnerID=MN8TOARS. 10.1073/pnas.1031632100 Sola, S.; Ma, X.; Castro, R.E.; Kren, B.T.; Steer, C.J.; Rodrigues, C.M.. "Ursodeoxycholic acid modulates E2F-1 and p53 expression through a caspase-independent mechanism in transforming growth factor beta1-induced apoptosis of rat hepatocytes.". The Journal of biological chemistry 278 49 (2003): 48831-48838. http://www.scopus.com/inward/record.url?eid=2-s2.0-1542467261&partnerID=MN8TOARS. 10.1074/jbc.M300468200 Rodrigues, C.M.P.; Spellman, S.R.; Solá, S.; Grande, A.W.; Linehan-Stieers, C.; Low, W.C.; Steer, C.J.. "Neuroprotection by a bile acid in an acute stroke model in the rat". Journal of Cerebral Blood Flow and Metabolism 22 4 (2002): 463-471. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036203113&partnerID=MN8TOARS. 10.1097/00004647-200204000-00010 Solá, S.; Diógenes, M.J.; Brites, D.; Rodrigues, C.M.P.. "Bilirubin, amyloid ß-peptide, and glycochenodeoxycholate directly induce cytochrome c release from isolated mitochondria,Libertação de citocromo c por interacção da bilirrubina, do ß-amilóide e do glicoquenodesoxicolato com mitocôndrias isoladas". Acta Medica Portuguesa 15 4 (2002): 269-275. http://www.scopus.com/inward/record.url?eid=2-s2.0-1842835881&partnerID=MN8TOARS. Rodrigues, C.M.P.; Solá, S.; Brites, D.. "Bilirubin induces apoptosis via the mitochondrial pathway in developing rat brain neurons". Hepatology 35 5 (2002): 1186-1195. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036238782&partnerID=MN8TOARS. 10.1053/jhep.2002.32967 Sola, S.; Brito, M.A.; Brites, D.; Moura, J.J.G.; Rodrigues, C.M.P.. "Membrane structural changes support the involvement of mitochondria in the bile salt-induced apoptosis of rat hepatocytes". Clinical Science 103 5 (2002): 475-485. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036846834&partnerID=MN8TOARS. 10.1042/cs1030475 Keene, C.D.; Rodrigues, C.M.P.; Eich, T.; Chhabra, M.S.; Steer, C.J.; Low, W.C.. "Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic animal model of Huntington's disease". Proceedings of the National Academy of Sciences of the United States of America 99 16 (2002): 10671-10676. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036677435&partnerID=MN8TOARS. 10.1073/pnas.162362299 Duan, W.-M.; Rodrigues, C.M.P.; Zhao, L.-R.; Steer, C.J.; Low, W.C.. "Erratum: Tauroursodeoxycholic acid improves the survival and function of nigral transplants in a rat model of Parkinson's Disease (Cell Transplantation 11:3 (195-205))". Cell Transplantation 11 6 (2002): 619-619. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036414679&partnerID=MN8TOARS. Rodrigues, C.M.P.; Solá, S.; Castro, R.E.; Laires, P.A.; Brites, D.; Moura, J.J.G.. "Perturbation of membrane dynamics in nerve cells as an early event during bilirubin-induced apoptosis". Journal of Lipid Research 43 6 (2002): 885-894. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035988343&partnerID=MN8TOARS. Rodrigues, C.M.P; Solá, S.; Brito, M.A.; Brites, D.; Moura, J.J.G. "Bilirubin directly disrupts membrane lipid polarity and fluidity, protein order, and redox status in rat mitochondria". Journal of Hepatology 36 3 (2002): 335-341. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036191788&partnerID=MN8TOARS. 10.1016/S0168-8278(01)00279-3 Rodrigues, C.M.P.; Solá, S.; Silva, R.F.M.; Brites, D.. "Aging confers different sensitivity to the neurotoxic properties of unconjugated bilirubin". Pediatric Research 51 1 (2002): 112-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036134456&partnerID=MN8TOARS. 10.1203/00006450-200201000-00020 Silva, R.F.M.; Rodrigues, C.M.P.; Brites, D.. "Rat cultured neuronal and glial cells respond differently to toxicity of unconjugated bilirubin". Pediatric Research 51 4 I (2002): 535-541. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036202904&partnerID=MN8TOARS. 10.1203/00006450-200204000-00022 Silva, R.F.M.; Rodrigues, C.M.P.; Brites, D.. "Bilirubin-induced apoptosis in cultured rat neural cells is aggravated by chenodeoxycholic acid but prevented by ursodeoxycholic acid". Journal of Hepatology 34 3 (2001): 402-408. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035072101&partnerID=MN8TOARS. 10.1016/S0168-8278(01)00015-0 Kaemmerer, W.F.; Rodrigues, C.M.P.; J. Steer, C.; Low, W.C.. "Creatine-supplemented diet extends Purkinje cell survival in spinocerebellar ataxia type 1 transgenic mice but does not prevent the ataxic phenotype". Neuroscience 103 3 (2001): 713-724. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035925748&partnerID=MN8TOARS. 10.1016/S0306-4522(01)00017-3 Keene, C.Dirk; Rodrigues, C.M.P.; Eich, T.; Linehan-Stieers, C.; Abt, A.; Kren, B.T.; Steer, C.J.; Low, W.C.. "A bile acid protects against motor and cognitive deficits and reduces striatal degeneration in the 3-nitropropionic acid model of Huntington's disease". Experimental Neurology 171 2 (2001): 351-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034799214&partnerID=MN8TOARS. 10.1006/exnr.2001.7755 Rodrigues, C.M.P.; Steer, C.J.. "The therapeutic effects of ursodeoxycholic acid as an anti-apoptotic agent". Expert Opinion on Investigational Drugs 10 7 (2001): 1243-1253. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034942512&partnerID=MN8TOARS. 10.1517/13543784.10.7.1243 Kren, B.T.; Rodrigues, C.M.P.; Setchell, K.D.R.; Steer, C.J.. "Modulation of steady-state messenger RNA levels in the regenerating rat liver with bile acid feeding". Liver Transplantation 7 4 (2001): 321-334. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035054316&partnerID=MN8TOARS. 10.1053/jlts.2001.23062 Rodrigues, C.M.P.; Solá, S.; Brito, M.A.; Brondino, C.D.; Brites, D.; Moura, J.J.G.. "Amyloid ß-peptide disrupts mitochondrial membrane lipid and protein structure: Protective role of Tauroursodeoxycholate". Biochemical and Biophysical Research Communications 281 2 (2001): 468-474. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034812181&partnerID=MN8TOARS. 10.1006/bbrc.2001.4370 Rodrigues, C.M.; Solá, S.; Silva, R.; Brites, D.. "Bilirubin and amyloid-beta peptide induce cytochrome c release through mitochondrial membrane permeabilization.". Molecular medicine (Cambridge, Mass.) 6 11 (2000): 936-946. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034327232&partnerID=MN8TOARS. Rodrigues, C.M.P.; Brites, D.; Serejo, F.; Costa, A.; Ramalho, F.; Carneiro De Moura, M.. "Apoptotic cell death does not parallel other indicators of liver damage in chronic hepatitis c patients". Journal of Viral Hepatitis 7 3 (2000): 175-183. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034110523&partnerID=MN8TOARS. 10.1046/j.1365-2893.2000.00219.x Rodrigues, C.M.P.; Stieers, C.L.; Keene, C.D.; Ma, X.. "Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: Evidence for a mitochondrial pathway independent of the permeability transition". Journal of Neurochemistry 75 6 (2000): 2368-2379. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033769186&partnerID=MN8TOARS. 10.1046/j.1471-4159.2000.0752368.x Trembley, J.H.; Chen, Z.; Rodrigues, C.M.P.; Kren, B.T.; Steer, C.J.. "Genomic organization and promoter characterization of the rat cyclin B1 gene". Gene 255 1 (2000): 93-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034609436&partnerID=MN8TOARS. 10.1016/S0378-1119(00)00319-X Rodrigues, C.M.P.; Steer, C.J.. "Mitochondrial membrane perturbations in cholestasis". Journal of Hepatology 32 1 (2000): 135-141. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033985520&partnerID=MN8TOARS. 10.1016/S0168-8278(00)80200-7 Rodrigues, C.M.P.; Steer, C.J.. "Bile acids and hepatocyte apoptosis: Living/leaving life in the Fas lane". Gastroenterology 117 3 (1999): 732-736. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032820249&partnerID=MN8TOARS. 10.1016/S0016-5085(99)70469-5 Rodrigues, C.M.P.; Marín, J.J.G.; Brites, D.. "Bile acid patterns in meconium are influenced by cholestasis of pregnancy and not altered by ursodeoxycholic acid treatment". Gut 45 3 (1999): 446-452. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032775761&partnerID=MN8TOARS. 10.1136/gut.45.3.446 Rodrigues, C.M.P.; Ma, X.; Linehan-Stieers, C.; Fan, G.; Kren, B.T.; Steer, C.J.. "Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation". Cell Death and Differentiation 6 9 (1999): 842-854. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032846812&partnerID=MN8TOARS. 10.1038/sj.cdd.4400560 Rodrigues, C.M.P.; Fan, G.; Ma, X.; Kren, B.T.; Steer, C.J.. "A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation". Journal of Clinical Investigation 101 12 (1998): 2790-2799. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032525819&partnerID=MN8TOARS. 10.1172/JCI1325 Brites, D.; Rodrigues, C.M.P.; Cardoso, M.D.C.; Graça, L.M.. "Unusual case of severe cholestasis of pregnancy with early onset, improved by ursodeoxycholic acid administration". European Journal of Obstetrics Gynecology and Reproductive Biology 76 2 (1998): 165-168. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032007521&partnerID=MN8TOARS. 10.1016/S0301-2115(97)00185-1 Brites, D.; Rodrigues, C.M.P.; Van-Zeller, H.; Alexandra Brito; Silva, R.. "Relevance of serum bile acid profile in the diagnosis of intrahepatic cholestasis of pregnancy in an high incidence area: Portugal". European Journal of Obstetrics Gynecology and Reproductive Biology 80 1 (1998): 31-38. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032458943&partnerID=MN8TOARS. 10.1016/S0301-2115(98)00086-4 Brites, D.; Rodrigues, C.M.P.; Oliveira, N.; Cardoso, M.D.C.; Graça, L.M.. "Correction of maternal serum bile acid profile during ursodeoxycholic acid therapy in cholestasis of pregnancy". Journal of Hepatology 28 1 (1998): 91-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031952407&partnerID=MN8TOARS. 10.1016/S0168-8278(98)80207-9 Rodrigues, C.M.P.; Fan, G.; Wong, P.Y.; Kren, B.T.; Steer, C.J.. "Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production". Molecular Medicine 4 3 (1998): 165-178. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031950282&partnerID=MN8TOARS. Setchell, K.D.R.; Rodrigues, C.M.P.; Clerici, C.; Solinas, A.; Morelli, A.; Gartung, C.; Boyer, J.. "Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei". Gastroenterology 112 1 (1997): 226-235. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031024075&partnerID=MN8TOARS. 10.1016/S0016-5085(97)70239-7 Setchell, K.D.R.; Rodrigues, C.M.P.; Podda, M.; Crosignani, A.. "Metabolism of orally administered tauroursodeoxycholic acid in patients with primary biliary cirrhosis". Gut 38 3 (1996): 439-446. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029863605&partnerID=MN8TOARS. 10.1136/gut.38.3.439 Rodrigues, C.M.P.; Kren, B.T.; Steer, C.J.; Setchell, K.D.R.. "Formation of ¿22-bile acids in rats is not gender specific and occurs in the peroxisome". Journal of Lipid Research 37 3 (1996): 540-550. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029666426&partnerID=MN8TOARS. Crosignani, A.; Setchell, K.D.R.; Invernizzi, P.; Larghi, A.; Rodrigues, C.M.P.; Podda, M.. "Clinical pharmacokinetics of therapeutic bile acids". Clinical Pharmacokinetics 30 5 (1996): 333-358. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029922694&partnerID=MN8TOARS. 10.2165/00003088-199630050-00002 Rodrigues, C.M.P.; Setchell, K.D.R.. "Performance characteristics of reversed-phase bonded silica cartridges for serum bile acid extraction". Biomedical Chromatography 10 1 (1996): 1-5. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030028096&partnerID=MN8TOARS. 10.1002/(SICI)1099-0801(199601)10:1<1::AID-BMC536>3.0.CO;2-3 Kren, B.T.; Rodrigues, C.M.P.; Setchell, K.D.R.; Steer, C.J.. "Posttranscriptional regulation of mRNA levels in rat liver associated with deoxycholic acid feeding". American Journal of Physiology - Gastrointestinal and Liver Physiology 269 6 32-6 (1995): http://www.scopus.com/inward/record.url?eid=2-s2.0-0029558347&partnerID=MN8TOARS. Setchell, K.D.R.; Rodrigues, C.M.P.; O'Connell, N.C.; Yamashita, H.; Kren, B.T.; Steer, C.J.. "¿²²-Ursodeoxycholic Acid, a Unique Metabolite of Administered Ursodeoxycholic Acid in Rats, Indicating Partial ß-Oxidation as a Major Pathway for Bile Acid Metabolism". Biochemistry 34 13 (1995): 4169-4178. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028986129&partnerID=MN8TOARS. 10.1021/bi00013a004 Rodrigues, C.M.P.; Kren, B.T.; Steer, C.J.; Setchell, K.D.R.. "The site-specific delivery of ursodeoxycholic acid to the rat colon by sulfate conjugation". Gastroenterology 109 6 (1995): 1835-1844. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028842929&partnerID=MN8TOARS. 10.1016/0016-5085(95)90750-5 Rodrigues, C.M.P.; Kren, B.T.; Steer, C.J.; Setchell, K.D.R.. "Tauroursodeoxycholate increases rat liver ursodeoxycholate levels and limits lithocholate formation better than ursodeoxycholate". Gastroenterology 109 2 (1995): 564-572. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029098462&partnerID=MN8TOARS. 10.1016/0016-5085(95)90346-1 Brites, D.; Poeiras, J.; Rodrigues, C.. "Intrahepatic cholestasis in pregnancy. Its etiopathogenesis, prognosis and therapy \| Colestase intra-hepática da gravidez. Etiopatogénese, prognóstico e terapêutica.". Acta medica portuguesa 7 3 (1994): 181-188. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028391098&partnerID=MN8TOARS.
Capítulo de livro	Simão, A.L.; Borralho, P.M.; Steer, C.J.; Castro, R.E.; Rodrigues, C.M.P.. "Isolation of Mitochondria from Liver and Extraction of Total RNA and Protein: Analyses of miRNA and Protein Expression". 1-15. 2021. 10.1007/978-1-0716-1433-4_1 Simão, A.L.; Borralho, P.M.; Steer, C.J.; Castro, R.E.; Rodrigues, C.M.P. (DC18-39A7-F287). "Isolation of mitochondria from liver and extraction of total RNA and protein – analyses of miRNA and protein expression". In Mitochondrial Regulation: Methods and Protocols. Methods in Molecular Biology. Springer, 2020. No prelo Pinheiro, M.; Rodrigues, C.M.P. (DC18-39A7-F287). "Systems Medicine Overview: Metabolic and Cardiovascular Disease". In Systems Medicine: Integrative, Qualitative and Computational Approaches. Elsevier Science, 2020. No prelo Afonso, M.B.; Rodrigues, C.M.P.. "Necrosome formation and necroptosis in experimental cholestasis". In Methods in Molecular Biology, 149-162. Humana Press Inc., 2019. Publicado • 10.1007/978-1-4939-9420-5_10 Sousa, T.; Castro, R.E.; Coutinho, A.; Rodrigues, C.M.P.; Prieto, M.; Fernandes, F.. "Measuring the impact of bile acids on the membrane order of primary hepatocytes and isolated mitochondria by fluorescence imaging and spectroscopy". In Methods in Molecular Biology, 99-115. Humana Press Inc., 2019. Publicado • 10.1007/978-1-4939-9420-5_7 Solá, S.; Ribeiro, M.F.; Genebra, T.; Rodrigues, C.M.P.. "Modulation of cell fate by tauroursodeoxycholic acid: All paths lead to mitochondria". In Mitochondrial Biology and Experimental Therapeutics, 407-421. Springer, 2018. Publicado Pereira, D.M.; Rodrigues, C.M.P.. "miRNAs as modulators of EGFR therapy in colorectal cancer". In Targeted Therapy of Colorectal Cancer Subtypes. Advances in Experimental Medicine and Biology, 133-147. Springer, 2018. Publicado • 10.1007/978-3-030-02771-1_9 Machado, M.V.; Ferreira, D.M.S.; Castro, R.E.; Silvestre, A.R.; Evangelista, T.; Coutinho, J.; Carepa, F.; et al. "Liver and muscle in morbid obesity: The interplay of fatty liver and insulin resistance". In Obesity Epidemiology, Pathogenesis, and Treatment: A Multidisciplinary Approach, 145-173. Apple Academic Press, 2016. Publicado • 10.1371/journal.pone.0031738 Borralho, P.M.; Rodrigues, C.M.P.; Steer, C.J.. "microRNAs in mitochondria: An unexplored niche". In Advances in Experimental Medicine and Biology, 31-51. Springer, 2015. Publicado • 10.1007/978-3-319-22380-3_3 Borralho, P.M.; Steer, C.J.; Rodrigues, C.M.P.. "Isolation of mitochondria from liver and extraction of total RNA and protein: Analyses of microRNA and protein expressions". In Mitochondrial Regulation: Methods and Protocols, 9-12. Springer, 2015. 10.1007/978-1-4939-1875-1_2 Ramalho, R.M.; Viana, R.J.S.; Nunes, A.F.; Low, W.C.; Steer, C.J.; Rodrigues, C.M.P.. "Control of apoptosis in experimental alzheimer’s disease: Therapeutic opportunities for an ancient bile acid". In Neurochemistry: Molecular Aspects, Cellular Aspects and Clinical Applications, 103-131. Nova Science Publishers, 2010. Publicado Amaral, J.D.; Solá, S.; Steer, C.J.; Rodrigues, C.M.P.. "Nuclear steroid receptors in apoptosis". In Modern Insights Into Disease From Molecules to Man: Apoptosis, 113-129. Science Publishers, 2010. Publicado Castro, R.E.; Solá, S.; Steer, C.J.; Rodrigues, C.M.P.. "Bile Acids as Modulators of Apoptosis". In Hepatotoxicity: From Genomics to in-vitro and in-vivo, 391-419. Jonh Wiley & Sons, 2008. Publicado Rodrigues, C.M.P.; Castro, R.E.; Steer, C.J.. "The Role of Bile Acids in the Modulation of Apoptosis". In Principles of Medical Biology. The Liver in Biology and Disease, 119-146. Elsevier Science, 2004. Publicado • 10.1016/S1569-2582(04)15005-8
Livro	Rodrigues, CMP; Rodrigues, Cecília. Systems Medicine: Integrative, Qualitative and Computational Approaches (Olaf Wolkenhauer, Ed.; Cecilia Rodrigues, section Ed.). Elsevier Science. 2020. No prelo • Editor

Propriedade Intelectual

Patente

Finch, M.D.; Low, W.C.; Steer, C.J.; Munshi, C.B.; Rodrigues, C.M.P. (DC18-39A7-F287); Lucas de Oliveira, S.D.. 2018. "Finch MD, Low W, Steer C, Munshi CB, Rodrigues CMP, Lucas de Oliveira SD, Deuterated Bile Acids. Publication number: Pub. Date: Feb. 1, 2018. Pub. No. US20180030084A1. Family: US(3) WO (1). 2014: US14520889; 2016 US15052221; 2017 US15651721; 2018 US20180030084A1.".
Finch, M.D.; Munshi, C.B.; Rodrigues, C.M.P. (DC18-39A7-F287); de Oliveira, S.D.L.. 2018. "Finch M, Munshi CB, Rodrigues CMP, de Oliveira SDL. Fluorinated and Alkylated Bile Acids. US Patent App. 15/556,768, 2018 US20180044373A1".
Rodrigues, Cecília. 2013. "Tauroursodeoxycholic Acid Attenuates or Abolishes Formation and Deposition of Amyloid-ß Peptide. Provisional. Pub. Date: September 23, 2013. Publication number: WO2013142490A2.".
Rodrigues, Cecília. 2008. "Methods for Treating Visual Disorders. Pub. Date: August 14, 2008. Pub. No. US20080194531 A1. Also published as EP1871385A1, WO2006086452A1.".
Rodrigues, Cecília. 2006. "Methods of Treating Injuries of the Nervous System Associated with Hemorrhage. Pub. Date: June 22, 2006. Pub. No. Serial No. US20060135494 A1. Also published as DE60330501D1, EP1575578A2, EP1575578A4, EP1575578B1, WO2004043342A2, WO2004043342A3.".
Steer, C.J.; Kren, B.T.; Fan, G.; Rodrigues, C.M (DC18-39A7-F287). 2003. "Methods of Limiting Apoptosis of Cells. Pub. Date: April 8, 2003. Publication No. US6544972 B1. Also published as WO1999015179A1, WO1999015179A8, WO1999015179A9, US2003044413A1.".
Concedida/Emitida

Outros

Outra produção

Microfluidic Detection of Adenylate Kinase as Cell Damage Biomarker and Integration with a Cell Chip. 2022. Domingues, C.; Fontes, P.M.; Condelipes, P.G.M.; Marques, V.; Afonso, M.B.; Chu, V.; Rodrigues, C.M.P.; Conde, J.P.. http://www.scopus.com/inward/record.url?eid=2-s2.0-85144138915&partnerID=MN8TOARS.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2020/01/01	Total of ca. 250 oral communications (> 100 international)
2020	Circulating miR-335 is reduced in Parkinson’s disease patients and its overexpression negatively regulates inflammatory events	AD/PD Meeting 2020 AD/PD (Viena, Alemanha)
2019	Diet-associated gut microbiota metabolites dictate mitochondrial stress as a key regulator of adult neurogenesis.	11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies Portuguese Society for Stem Cells and Cell Therapies (Lisboa, Portugal)
2019	Discovery of colon cancer stem cell inhibitors by high-throughput screening in a 3D spheroid model.	11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies Portuguese Society for Stem Cells and Cell Therapies (Lisboa, Portugal)
2019	Tuning cell death in neuroinflammation.	53rd Annual Scientific Meeting of the European Society for Clinical Investigation European Society for Clinical Investigation (Coimbra, Portugal)
2019	RIP3 deficiency remodels mitochondrial bioenergetics and function in experimental NAFLD	53rd Annual Scientific Meeting of the European Society for Clinical Investigation European Society for Clinical Investigation (Coimbra, Portugal)
2019	High-throughput phenotypic screening of colon cancer stem cell inhibitors using tumourspheres.	27th United European Gastroenterology Week United European Gastroenterology (Barcelona, Espanha)
2019	miRNA-21 signals through a gut-liver axis to regulate experimental cholestasis.	The International Liver Congress European Association for the Study of the Liver European Association for the Study of the Liver (Vienna, Alemanha)
2019	Genetic deletion of RIP3 abrogates dopaminergic neuronal death in the MPTP-mouse model of Parkinson’s disease	AD/PD 2019, 14th International Conference on Alzheimer's and Parkinson's DiseasesAD/PD 2019 AD/PD 2019 (Lisboa, Portugal)
2019	Nanoformulated hybrid molecules with high in vitro and in vivo potential against melanoma	EUFEPS Annual Meeting 2019 EUFEPS (Frankfurt, Alemanha)
2019	FXR mode of action dans le maladie chroniques du foie	85e Journées Scientifiques de l’APEF. 20e Journée de Formation Médicale Continue en Hétatologie APEF (Marselha, França)
2019	Metabolic liver disease	ICAN Series 2019. Cardiometabolic disease interfaces: defining new paradigms ICAN (Paris, França)
2019	Genetics and epigenetics of NAFLD progression	Symposium Molecular basis of non-alcoholic fatty liver disease progression V UIMP-IBIS School of Biomedicine (Sevilha, Espanha)
2018	Muscle miR-34a is activated during NAFLD progression, promoting insulin resistance and mitochondrial dynamics dysfunction	26th United European Gastroenterology Week United European Gastroenterology (Viena, Alemanha)
2018	Deregulation of small intestine permeability by miRNA-21 in liver disease.	9th biennial meeting for the Society for Free Radical Research International Society for Free Radical Research International (Lisboa, Portugal)
2017	miRNAs as biomarkers and targets.	European Association for the Study of the Liver, NAFLD Summit European Association for the Study of the Liver (Roma, Itália)
2017	miRNAs as biomarkers and regulators of liver disease.	51st Conference of the European Society for Clinical Investigation European Society for Clinical Investigation (Genova)
2017	Molecular markers in colorectal cancer: miRNAs and its clinical implications.	Leaping Forward Oncology – International Clinical Congress (Lisboa, Portugal)
2017	miR-21 ablation and obeticholic acid ameliorate NASH in mice	Keystone Symposium Bile Acid Receptors as Signal Integrators in Liver and Metabolism Keystone Symposia (Monterey, Estados Unidos)
2016	Selective targeting of FXRa isoforms by novel bile acid derivatives is associated with inhibition of lipotoxicity in liver cells	24th United European Gastroenterology Week United European Gastroenterology (Viena, Alemanha)
2016	Activation of necroptosis in human and experimental cholestasis	24th United European Gastroenterology Week United European Gastroenterology (Viena, Alemanha)
2016	The role of miRNA-145 in colon cancer stem cell-like cells.	24th United European Gastroenterology Week United European Gastroenterology (Viena, Alemanha)
2016	Improving metabolic parameters in NAFLD by targeting nuclear receptors	24th United European Gastroenterology Week United European Gastroenterology (Viena, Alemanha)
2016	RIP3 regulates acute cholestasis-associated necroptotic signaling and cell death.	The International Liver Congress European Association for the Study of the Liver European Association for the Study of the Liver (Barcelona, Espanha)
2015	Alcoholic and non-alcoholic steatohepatitis: Mechanisms of cell death and clinical relevance	XX Annual Conference “Hepatology Today 2015” EASL/RSLS Symposium RSLS/EASL (Moscovo, Rússia)
2015	Dual targeting of microRNA-21 and FXR ameliorates NAFLD pathogenesis in mice.	23rd United European Gastroenterology Week United European Gastroenterology (Barcelona, Espanha)
2015	MEK5/ERK5 signalling controls colon cancer cell sensitivity to 5-fluorouracil through a p53 dependent mechanism	23rd United European Gastroenterology Week United European Gastroenterology (Barcelona, Espanha)
2015	Contribution of miRNA-143 and miRNA-145 to cetuximab-mediated cellular cytotoxicity in colon cancer cells	23rd United European Gastroenterology Week United European Gastroenterology (Barcelona, Espanha)
2015	The dual role of necroptosis in cholestasis	23th Euroconference on Apoptosis “Death Pathways and Beyond” European Cell Death Organization (Genebra, Suiça)
2014	MEK5/ERK5 signalling activates NF-¿B and promotes a more aggressive phenotype in human colon cancer cells	22nd United European Gastroenterology Week United European Gastroenterology (Viena, Alemanha)
2014	Deoxycholic acid trigers primary rat hepatocyte apoptosis in a dose-dependent manner by hampering caspase-2/NF-¿¿-associated activation of miRNA-21	64th Annual Meeting of the American Association for the Study of Liver Diseases American Association for the Study of Liver Diseases (Washington, Estados Unidos)
2014	Moving Forward: Discussions on implications for patients from basic research, Joint Workshop EASL-I-PSC-G	The International Liver Congress European Association for the Study of the Liver European Association for the Study of the Liver (Londres, Reino Unido)
2013	Bile acids: hepatotoxicity and hepatoprotection.	The International Liver Congress European Association for the Study of the Liver European Association for the Study of the Liver (Londres, Reino Unido)
2013	miR-143 and miR-145 overexpression improve the response to cetuximab in HCT116 KRAS mutant colon cancer cells	21st United European Gastroenterology Week United European Gastroenterology (Berlim, Alemanha)
2013	MEK5/ERK5 signalling modulates cell proliferation and survival and influences sensitivity to 5-fluorouracil in colon cancer cells	21st United European Gastroenterology Week United European Gastroenterology (Berlim, Alemanha)
2013	MEK5/ERK5 expression is increased in colon cancer adenomas and adenocarcinomas, and MEK5/ERK5 signalling accelerates cell cycle progression and migration in SW620 colon cancer cells	21st United European Gastroenterology Week United European Gastroenterology (Berlim, Alemanha)
2013	Skeletal muscle miRNAs and correlation with liver miRNAs in non-alcoholic fatty liver disease, and targeting by tauroursodeoxycholic acid in vitro	21st United European Gastroenterology Week United European Gastroenterology (Berlim, Alemanha)
2013	JNK1-dependent modulation of miR-34a contributes to apoptosis induced by deoxycholic acid in primary rat hepatocytes	The International Liver Congress European Association for the Study of the Liver European Association for the Study of the Liver (Amsterdão)
2012	miR-34a/SIRT1/p53 signaling is activated in human non-alcoholic fatty liver disease and target by ursodeoxycholic acid in the rat liver via inhibition of p53 transactivation	20th United European Gastroenterology Week United European Gastroenterology (Amsterdão)
2012	Apoptotic miRNA-21/PDCD4 signaling in rat hepatocytes: dose-dependent effect of deoxycholic acid	The International Liver Congress European Association for the Study of the Liver European Association for the Study of the Liver (Barcelona, Espanha)
2011	Increased expression of miR-34 in NAFLD patients and targeting by ursodeoxycholic acid in rat liver	19th United European Gastroenterology Week United European Gastroenterology (Estocolmo, Suécia)
2009	Modulation of the p53-ubiquitin-proteasome degradation pathway by ursodeoxycholic acid	44th Annual Meeting of the European Association for the Study of the Liver European Association for the Study of the Liver (Copenhaga, Dinamarca)
2007	Antiapoptotic effect of ursodeoxycholic acid in hepatocytes.	Falk Research Workshop Falk Foundation (Goettingen, Alemanha)
2007	Differential regulation of cyclin D1 and apoptosis by bile acids in primary rat hepatocyte	42st Meeting of the European Association for the Study of Liver Diseases European Association for the Study of the Liver (Barcelona, Espanha)
2005	Targeting apoptosis in neurologic disorders.	4th International Congress on Vascular Dementia (Porto, Portugal)
2004	Tauroursodeoxycholic acid, a bile acid with in vivo anti-apoptotic and neuroprotective properties.	XVIII International Bile Acid Meeting Falk Foundation (Estocolmo, Suécia)
2004	Rodrigues CMP. Targeting apoptosis in human diseases.	26th European Society of Parental and Enteric Nutrition European Society of Parental and Enteric Nutrition (Lisboa, Portugal)
2004	Mechanisms of cell death in steatohepatitis – Apoptosis or necrosis?	EASL NASH Monothematic Conference European Association for the Study of the Liver (Lisboa, Portugal)
2004	Enhanced apoptosis and Bcl-2 protein production in the liver of patients with steatohepatitis	39th Meeting of the European Association for the Study of Liver Diseases European Association for the Study of the Liver (Berlim, Alemanha)
2003	Ursodeoxycholic acid prevents TGF-ß1-induced apoptosis through modulation of the glucocorticoid receptor in primary rat hepatocytes	54th Annual Meeting of the American Association for the Study of Liver Diseases American Association for the Study of Liver Diseases (Chicago, Estados Unidos)
2002	Tauroursodeoxycholic acid for the treatment of acute and chronic neurodegenerative diseases.	XVII International Bile Acid Meeting Falk Foundation (Freiburgo, Alemanha)
2000	Inhibition of apoptosis in a rat model of Huntington’s disease using tauroursodeoxycholate.	XVI International Bile Acid Meeting Falk Foundation (Haia, Países Baixos)
2000	Tauroursodeoxycholate prevents mitochondrial membrane perturbation induced by recombinant Bax protein	51st Annual Meeting of the American Association for the Study of Liver Diseases American Association for the Study of Liver Diseases (Chicago, Estados Unidos)
2000	Apoptosis induced by deoxycholic acid, unconjugated bilirubin and amyloid ß-peptide reflects mitochondrial perturbation which may be inhibited by ursodeoxycholic acid	35th Annual Meeting of the European Association for the Study of the Liver European Association for the Study of the Liver (Roterdão, Países Baixos)
1999	Ursodeoxycholic acid inhibits apoptosis by modulating depolarization and channel-forming activity of the mitochondrial membrane	34th Annual Meeting of the European Association for the Study of the Liver European Association for the Study of the Liver (Nápoles, Itália)
1998	Bile acid pattern in meconium is influenced by cholestasis of pregnancy and not altered after ursodeoxycholic acid therapy	49th Annual Meeting of the American Association for the Study of Liver Diseases American Association for the Study of Liver Diseases (Chicago, Estados Unidos)
1997	A novel role for ursodeoxycholic acid in modulating apoptosis in rat liver, isolated hepatocytes and human hepatoma cells	48th Annual Meeting of the American Association for the Study of Liver Diseases American Association for the Study of Liver Diseases (Chicago, Estados Unidos)
1994	Tauroursodeoxycholic acid (TUDCA) appears more effective than UDCA at displacing hydrophobic bile acids from the bile acid pool of patients with primary biliary cirrhosis	45th Annual Meeting of the American Association for the Study of Liver Diseases American Association for the Study of Liver Diseases (Chicago, Estados Unidos)

Orientação

	Título / Tema Papel desempenhado	Curso (Tipo) Instituição / Organização
2020/01/01 - Atual	Total of ca. 150 postgraduate student and postdoc supervisions (50 PhD students; 80 MSc students; 13 Postdocs) Orientador
2020 - 2023	Targeting superficial tumors using a nanotechnological hybrid approach Coorientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020 - 2023	Development of new necroptosis inhibitors: targeting RIP1 kinase Coorientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2023	Emerging Biomarkers, Targets and Therapies for Non-alcoholic Fatty Liver Disease Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2022	Innovative Therapies and Technologies in Cancer Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2021	Emerging inflammatory mediators as predictors of oocyte quality and IVF ART (assisted reproduction techniques) treatment outcome: from biochemical markers to clinic Coorientador	Ciências Farmacêuticas (Doutoramento) Universidade do Porto Faculdade de Farmácia, Portugal
2017 - 2021	Aromatase inhibitors in breast cancer: drug discovery and strategies to overcome acquired resistance Coorientador	Ciências Farmacêuticas Universidade do Porto Faculdade de Farmácia, Portugal
2017 - 2021	New Drugs to Target Neurodegeneration and Neuroinflammation in Parkinson’s Disease Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2021	Design, synthesis and biological evaluation of novel p53 activators by targeting p53 protein-protein interactions Coorientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2021	Response to neoadjuvant chemoradiation in rectal cancer. A study on clinical and molecular predictors of response Coorientador	Medicina (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 - 2021	Tetraoxane-based tumor-activated prodrug strategy to target intracellular labile ferrous iron Coorientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2021	miRNA Markers and Cell Death in NAFLD Progression Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2020	Targeting of mitofusin-2 by microRNAs in non-alcoholic fatty liver disease Coorientador	Farmácia (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2020	Therapeutic targeting of microRNA-21 and bile acid-activated receptors in non-alcoholic fatty liver disease Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2020	Role of adipose tissue-derived extracellular vesicles on liver cells under steatogenic conditions”, sob orientação de Rui Castro. Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2020	Bioenergetic Regulation of Neural Stem Cell Secretome: a Novel Therapeutic Opportunity for Neurodegeneration Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2020	New Drugs to Treat Fatty Liver and Progression to Cancer Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2020	Development and application of an innovative disposable sensor for Novel Psychoactive Substances (NPSs) based on electrochemistry Coorientador	Ciências Farmacêuticas (Doutoramento) Universidade do Porto Faculdade de Farmácia, Portugal
2018 - 2019	Quality and Reporting of Clinical Practice Guidelines on the Management of Parkinson’s Disease Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2019	Probing and Targeting Mitochondria Bioenergetics in Neurodegeneration Coorientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2019	Role of Mitofusin 2 in Non-alcoholic Fatty Liver Disease and Targeting by microRNAs Coorientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2019	Systems Analysis of Inflammation and Neuronal Demise in Neurodegenerative Diseases Coorientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2019	Neuroprotection by histone acetyltransferase modulators: activation or inhibition? Coorientador	Ciências Farmacêuticas (Doutoramento) Universidade do Porto Faculdade de Farmácia, Portugal
2014 - 2019	Exploring MEK5-ERK5 Signaling in Colorectal Cancer: A Therapeutic Target for Chemosensitization Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018	Role of the miR-21/MAPK signaling pathway and bile acid-activated receptors in non-alcoholic fatty liver disease progression Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018	Biological effects of phytocannabinoids and endocannabinoids on ER+ breast cancer cells Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018	Discovering New Molecules for Non-toxic Differentiation Therapy in Cancer Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018	Evaluating alterations in adenosine metabolism and function responsible for brown adipose tissue deregulation: Implications in obesity Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018	High Throughput Screening of Cell Fate Modulators Using Colon Cancer Stem Cells: Assay Development Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018	Targeting mitochondria-nucleus communication to improve agEing-impaired neurogenesis Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2018	Programmed Cell Death in Influenza Virus Sub-types Coorientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2017	Necroptosis and mitochondrial dysfunction in NAFLD: potential novel modulators Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2017	The role of mitochondrial adaptations in the acquistion of the phenotype induced by LDL-cholesterol in breast cancer Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2017	Role of Mi-2/NuRD in chromatin regulation to regulate neural stem cell fate and life-span in Drosophila melanogaster Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2017	Lectins in Mediterranean flora. Evalutation of antitumor activity on HT29 colon cancer cells Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2017	Targeting Hepatocyte Necroptosis to Treat Liver Diseases Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2017	miR-143, -145 and -21 Modulation in Colon Cancer - from Anticancer Activity to Drug Sensitization Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2017	Targeting of miR-21 and Bile Acid Activated Receptors in Non-alcoholic Fatty Liver Disease Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016	Targeting microglia necroptosis to arrest neuroinflammation Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016	Screening of necroptosis modulators with potential therapeutic application Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016	Molecular insights into the role of alpha-synuclein phosphorylation in synucleinophathies Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016	Spirooxadiazoline oxindoles as potential anticancer agents Coorientador	Química Farmacêutica e Terapêutica (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2016	Targeting MicroRNAs for Modulation of the Anti-Tumor Human gd T Cell Differentiation Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2016	Efeitos do tratamento com N-acetilcisteina sob o défice cognitivo induzido por estreptozotocina em camundongos Coorientador	Universidade Federal de Santa Maria, Brasil
2012 - 2015	Novel Therapeutic Targets in Colon Cancer Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2015	Fine-Tuning Neurogenesis: miRNA Regulatory Networks Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2015	Control of Neuronal Signalling Pathways by CYP46A1, an Enzyme Involved in Brain Cholesterol Homeostasis Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 - 2015	Design and Synthesis of Small Molecule Modulators of p53 Coorientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2014	Using TUDCA to Treat AD Pathology in APP/PS1 Mice after Disease Onset Orientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2014	Inhibition of Mutant KRAS Transcription in Human Cancer Orientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2014	A New Regulatory Mechanism Involving p53 in JMJD3-mediated Neurogenesis Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2013	Exploring the Role of MEK5/ERK5 Signaling in Colon Cancer and Sensitivity to 5 Fluorouracil Orientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2009 - 2013	Avaliação do efeito neuroprotetor do p, p’-dimetoxil disseleneto de difenila em modelos de demência decorrentes da Doença de Alzheimer em roedores: Estudo dos mecanismos envolvidos Coorientador	Universidade Federal de Santa Maria, Brasil
2009 - 2013	Apoptosis and miRNAs in Non-Alcoholic Fatty Liver Disease Pathogenesis Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 - 2012	Creatine Protects Against Rotenone-induced Cell Death of Cerebellar Granule Neurons Coorientador	Ciências Biofarmacêuticas (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2009 - 2012	Amyloid ß Peptide and p63: Two Prime Triggers of Neural Apoptosis and Differentiation Orientador	Neurociências (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2008 - 2012	Regulation of Neural Stem Cell Proliferation by Apoptosis-relevant Factors Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2012	Endogenous Regulatory Circuits Controlled by CYP46A1: Role of 24S-hydroxycholestreol on Small GTPase Activity and its Relation to Neurodegenerative Disorders with Altered Brain Cholesterol Metabolism Coorientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2011	Exploring Antibody-mediated Small RNA Delivery as a Therapeutic Approach in Colon Cancer Orientador	Bioquímica (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2007 - 2011	Apoptosis Signaling Associated with Amyloid beta-induced Cellular Dysfunction and Degeneration: Relevance for Alzheimer's disease Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2006 - 2010	Role of Apoptosis Factors during Mouse Neural Stem Cell Differentiation Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2005 - 2009	Role of Apoptosis and miRNAs in Identifying Novel Therapeutic Targets in Colon Cancer Orientador	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2004 - 2008	p53, a Novel Molecular Target of Ursodeoxycholic Acid in Modulating Hepatocyte Apoptosis Orientador de Joana Amaral	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2006 - 2007	Potential Role of Apoptosis During Neural Stem Cell Differentiation Orientador	Università degli Studi di Milano-Bicocca, Itália
2003 - 2007	Signaling Events in Tauroursodeoxycholic Acid Protection of Amyloid beta-peptide-induced Neuronal Death Orientador de Rita Ramalho	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2002 - 2006	Tauroursodeoxycholic Acid Protection of Stroke: Targeting Cell Survival Cascades Orientador de Rui Castro	Farmácia (Doutoramento) Universidade de Lisboa Faculdade de Farmácia, Portugal
2001 - 2005	Modulation of Hepatocyte Apoptosis by Ursodeoxycholic Acid: Role of Nuclear Steroid Receptors Orientador de Susana Solá	Farmácia Universidade de Lisboa Faculdade de Farmácia, Portugal

Organização de evento

Júri de grau académico

	Tema Tipo de participação	Nome do candidato (Tipo de grau) Instituição / Organização
2020/01/01	Total of ca. 220 MSc juries (president in >175); 120 PhD juries (main opponent in >100); 15 Habilitation juries (main opponent in 14)	(Outro)
2020	Provas de Agregação em Biologia Experimental e Biomedicina, especialidade em Biologia Molecular, Celular e do Desenvolvimento Arguente principal	Paulo Oliveira (Agregação) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2020	Targeting metabolism for resolving Non-Alcoholic Steatohepatitis Arguente principal	Jorge Simon Espinosa (Doutoramento) Universidad del País Vasco, Espanha
2019	Provas de Agregação em Biociências, especialidade de Bioquímica Arguente principal	Rui Carvalho (Agregação) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019	Identification of a new genetic defect in bile acid synthesis: ACOX2 partial deficiency. Molecular bases, pathophysiology and implication in idiopathic hepatocellular disease Arguente principal	Marta Alonso Pena (Doutoramento) Universidad de Salamanca, Espanha
2019	Responses to liver damage: macrophage plasticity in tissue recovery and dysbiotic drifts Arguente principal	Inês Coelho (Doutoramento) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2019	Pathophysiology of doxorubicin cardiotoxicity: from mitochondrial homeostasis to biological clocks Arguente principal	Luciana Ferreira (Doutoramento) Universidade de Coimbra Faculdade de Farmácia, Portugal
2018	Molecular mechanisms of bile acid-induced apoptosis and cytoprotection Arguente principal	Tânia Sousa (Doutoramento) Universidade de Lisboa Instituto Superior Técnico, Portugal
2018	Phenotypes in Inflammatory Bowel Disease Arguente principal	Joana Torres (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2018	The Role of Post-Translational Modifications on the Oligomerization, Aggregation and Toxicity of Mutant Huntingtin Arguente principal	Joana Santos (Doutoramento) Universidade de Lisboa Faculdade de Medicina, Portugal
2018	Gold nanoparticles for nanotheranostics in leukemia – Addressing chronic myeloid leukemia Arguente principal	Raquel Vinhas (Doutoramento) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017	Provas de Agregação em Farmácia, especialidade de Biologia Celular e Molecular Arguente principal	Isabel Carvalho (Agregação) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017	Provas de Agregação em Farmácia, especialidade de Bioquímica Arguente principal	Liliana Silva (Agregação) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016	Provas de Agregação, em Biologia Celular e Molecular Arguente principal	Elsa Bronze (Agregação) Universidade do Porto Faculdade de Farmácia, Portugal
2013	Provas de Agregação em Bioquímica, na especialidade de Bioquímica Estrutural Arguente principal	Cláudio Gomes (Agregação) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2012	Provas de Agregação em Farmácia, na especialidade de Biologia Celular e Molecular Arguente principal	Alexandra Brito (Agregação) Universidade de Lisboa Faculdade de Farmácia, Portugal
2011	Provas de Agregação em Farmácia, na especialidade de Bioquímica Arguente principal	Graça Soveral (Agregação) Universidade de Lisboa Faculdade de Farmácia, Portugal
2010	Provas de Agregação em Ciências da Saúde, na especialidade de Ciências Biomédicas Arguente principal	Cristina Rego (Agregação) Universidade de Coimbra Faculdade de Medicina, Portugal

Comissão de avaliação

	Descrição da atividade Tipo de assessoria	Instituição / Organização	Entidade financiadora
2014 - Atual	Research projects, Agence Nationale de la Recherche Avaliador	Agence nationale de la recherche, França	Agence nationale de la recherche
2018 - 2020	Research Consortia and Projects (LiSyM – Systems Medicine of the Liver), Federal Ministry of Finance - BMBF, Germany Avaliador	Bundesministerium der Finanzen, Alemanha	Bundesministerium der Finanzen
2019 - 2019	Research Projects (Biological and Medical Sciences), Austrian Science Fund Avaliador	Fonds zur Förderung der wissenschaftlichen Forschung, Áustria	Fonds zur Förderung der wissenschaftlichen Forschung
2017 - 2017	ERC Consolidator Grants, EU European Comission H2020 Especialista	European Research Council, Bélgica	European Research Council
2009 - 2017	Postdoc and PhD fellowships, Fundação para a Ciência e a Tecnologia Avaliador	Fundação para a Ciência e Tecnologia, Portugal	Fundação para a Ciência e Tecnologia
2013 - 2016	Research fellowships (Post-doc, Physician Scientists, Entry-level, Short-term) and Mentorships, European Association for the Study of the Liver Avaliador	European Association for the Study of the Liver, Suiça	European Association for the Study of the Liver
2015 - 2015	Research Perojects, Worldwide Cancer Research, UK Avaliador	Worldwide Cancer Research, Reino Unido	Worldwide Cancer Research
2015 - 2015	Research Projects, Centres of Excellence in Neurodegenerative disease (CoEN) Initiative	Deutsches Zentrum für Neurodegenerative Erkrankungen, Alemanha	Deutsches Zentrum für Neurodegenerative Erkrankungen
2008 - 2015	Research projects, Wellcome Trust, UK Avaliador	Wellcome Trust, Reino Unido	Wellcome Trust
2014 - 2014	European research projects for Cross-Disease Analysis of Pathways related to Neurodegenerative Diseases, EU Joint Programme Neurodegenerative Disease Research (JPND) Avaliador	EU Joint Programme Neurodegenerative Disease Research, Alemanha	EU Joint Programme Neurodegenerative Disease Research
2012 - 2014	Research projects, Alzheimer's Association, USA Avaliador	Alzheimer's Association, Estados Unidos	Alzheimer's Association
2013 - 2013	European research projects on Genetic, Epigenetic and Environmental Risk Factors, European Joint Programme Neurodegenerative Disease Research Avaliador	EU Joint Programme Neurodegenerative Disease Research, Alemanha	EU Joint Programme Neurodegenerative Disease Research
2013 - 2013	Investigador FCT, Fundação para a Ciência e a Tecnologia Avaliador	Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia
2012 - 2012	Research projects, Research Foundation Flanders, Brussels	Fonds Wetenschappelijk Onderzoek Vlaanderen, Bélgica	Fonds Wetenschappelijk Onderzoek Vlaanderen

Consultoria / Parecer

	Descrição da atividade	Instituição / Organização
2014 - Atual	Scientific Committee on Biosciences member, Santa Casa da Misericórdia de Lisboa	Santa Casa da Misericórdia de Lisboa, Portugal
2011 - Atual	Scientific Advisory Board member, Metselex, Inc., USA
2014 - 2016	Basic Science Concerted Action Group chair, European Association for the Study of the Liver	European Association for the Study of the Liver, Suiça
2013 - 2014	Basic Science Concerted Action Group member, European Association for the Study of the Liver	European Association for the Study of the Liver, Suiça
2005 - 2011	Scientific Advisory Board member, SMG Therapeutics, Inc., USA

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2020 - Atual	Seminários/Seminars I - da Descoberta ao Uso do Medicamento	Ciências Farmacêuticas (Mestrado integrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - Atual	Coordenador, Doutoramento em Farmácia	Farmácia (Doutoramento)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - Atual	Biomarcadores e Tecnologias Moleculares/Molecular Biomarkers and Technologies	Farmácia (Doutoramento)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - Atual	Coordenador, Mestrado em Ciências Biofarmacêuticas	Ciências Biofarmacêuticas (Mestrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - Atual	Sinalização Celular/Cell Sinalling	Ciências Biofarmacêuticas (Mestrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - Atual	Oncobiologgia/Oncobiology	Ciências Biofarmacêuticas (Mestrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
1999 - Atual	Bioquímica II/Biochemistry II	Ciências Farmacêuticas (Mestrado integrado)	Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2022	Diretor, FCT PhD Programme in Medicines and Pharmaceutical Innovation (i3DU)	FCT PhD Programme in Medicines and Pharmaceutical Innovation (i3DU) (Doctor of Philosophy)	Universidade de Lisboa Faculdade de Farmácia, Portugal

Membro de associação

	Nome da associação	Tipo de participação
2013 - Atual	Vice-presidente, FARM-ID - Associação da Faculdade de Farmácia para I&D	Vice-Presidente
1999 - Atual	Member, American Association for the Study of Liver Diseases	Member
2013 - 2016	Governing Board, European Association Study of the Liver (EASL)	Governing Board Member (Scientific Committee)
2007 - 2011	Direção, Sociedade Portuguesa de Hepatologia	Membro da Direção
2003 - 2011	Direção, Sociedade Portuguesa de Neurociências	Membro da Direção

Membro de comissão

	Descrição da atividade Tipo de participação	Instituição / Organização
2009 - Atual	Membro, Conselho Científico da Faculdade de Farmácia, Universidade de Lisboa Membro	Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2016	Membro, Conselho Científico das Ciências da Vida e da Saúde, Fundação para a Ciência e a Tecnologia (FCT), Portugal Membro	Fundação para a Ciência e a Tecnologia, Portugal
2013 - 2016	Chair, Basic Science Concerted Action Group, European Association for the Study of the Liver Coordenador	European Association for the Study of the Liver, Suiça
2014 - 2015	Vice-presidente, Conselho Científico da Faculdade de Farmácia, Universidade de Lisboa Presidente / Vice-presidente	Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2013	Membro, Comissão Executiva, Instituto de Investigação do Medicamento e Ciências Farmacêuticas Membro	Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Distinções

Prémio

2023	Mulheres na Ciência 2023 Ciência Viva, Portugal
2022	2022 Sir Hans Krebs medal from FEBS
2016	University of Lisbon Scientific Prize (Biomedical Sciences)
2003	Francisco Pulido Valente Science Award (Neurosciences) Fundação para a Ciência e a Tecnologia, Portugal
2000	European Society for Pediatric Research Young Investigator Award
2000	European Association for the Study of the Liver Sheila Sherlock Award (Hepatology) European Association for the Study of the Liver, Suiça
1999	European Association for the Study of the Liver Young Investigator Award European Association for the Study of the Liver, Suiça
1992	Ordem dos Farmacêuticos Academic Merit Honour Ordem dos Farmaceuticos, Portugal

Outra distinção

2021	Associate editor, Hepatology
2019	Editorial Board member, Journal of Hepatology
2019	Editorial Board member, Biomolecules (Chemical Biology section)
2019	Executive Editor, Journal of Physiology and Biochemistry
2016	Editorial Board member, Frontiers in Neuroscience (Neurodegeneration section)
2014	Editorial Board member (Founding Editor), Cell Stress
2011	Editorial Board member, Frontiers in Pharmacology (Experimental Pharmacology section)
2010	Associate Editor, Clinics and Research in Hepatology and Gastroenterology
2010	Associate Editor, Journal of Alzheimer's Disease
2004	Portuguese Nomination for the European Young Investigator Award Fundação para a Ciência e a Tecnologia, Portugal

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2018 - 2018	Basic Science Seminar “Targetable pathways in liver disease”, International Liver Congress 2018, European Association for the Study of the Liver (EASL), Paris, France (2018 - 2018) Seminário	European Association for the Study of the Liver, Suiça
2016 - 2016	International Liver Congress 2016, European Association for the Study of the Liver (EASL), Barcelona, Spain (2016 - 2016) Congresso (Coorganizador)	European Association for the Study of the Liver, Suiça
2016 - 2016	Basic Science Seminar “Gut-liver Axis”, International Liver Congress 2016, European Association for the Study of the Liver (EASL), Barcelona, Spain (2016 - 2016) Seminário (Coorganizador)	European Association for the Study of the Liver, Suiça
2016 - 2016	Joint Workshop “EASL-Cochrane Hepato-Biliary Group”, International Liver Congress 2016, European Association for the Study of the Liver, Barcelona, Spain (2016 - 2016) Oficina (workshop) (Coorganizador)
2016 - 2016	XIX Congresso Nacional de Bioquímica, da Sociedade Portuguesa de Bioquímica, Guimarães, Portugal (2016 - 2016) Congresso (Membro da Comissão Científica)	Sociedade Portuguesa de Bioquímica, Portugal
2015 - 2015	The International Liver Congress 2015, European Association for the Study of the Liver (EASL), Vienna, Austria. (2015 - 2015) Congresso	European Association for the Study of the Liver, Suiça
2015 - 2015	EASL-FLIP Joint Workshop on Advances in pathogenesis, diagnosis and clinical hotspots, International Liver Congres 2015, European Association for the Study of the Liver. International Liver Congress, Vienna, Austria. (2015 - 2015) Oficina (workshop) (Coorganizador)
2015 - 2015	Seminar “Young Investigator Seminar – Liver Cell Death", International Liver Congress 2015, European Association for the Study of the Liver, Vienna, Austria. (2015 - 2015) Seminário (Coorganizador)	European Association for the Study of the Liver, Suiça
2014 - 2014	The International Liver Conggress, European Association for the Study of the Liver (EASL), London, UK, 2014 (2014 - 2014) Congresso (Coorganizador)	European Association for the Study of the Liver, Suiça
2014 - 2014	EASL-I-PSC-SG (International PSC Study Group) Joint Workshop, International Liver Congress 2014, European Association for the Study of the Liver., London, UK. (2014 - 2014) Oficina (workshop) (Coorganizador)	European Association for the Study of the Liver, Suiça
2013 - 2013	Translational Workshop “Modulation of Liver Injury and Metabolism Through Bile Acid Receptors”, International Liver Congress of the European Association for the Study of the Liver 2013, Amsterdam, Holland. (2013 - 2013) Oficina (workshop) (Coorganizador)	European Association for the Study of the Liver, Suiça
2010 - 2010	Simpósio “Redox, Stress and Cell Death”, XVII Congresso Nacional de Bioquímica 2010, Porto, Portugal (2010 - 2010) Simpósio (Membro da Comissão Científica)	Sociedade Portuguesa de Bioquímica, Portugal
2006 - 2006	Simpósio “Neurobiologia”, Congresso Nacional de Bioquímica 2006, Aveiro, Portugal (2006 - 2006) Simpósio (Membro da Comissão Científica)	Sociedade Portuguesa de Bioquímica, Portugal
2004 - 2004	Simpósio “Neuroquímica”, XIV Congresso Nacional de Bioquímica 2004, Vilamoura, Portugal (2004 - 2004) Simpósio (Membro da Comissão Científica)	Sociedade Portuguesa de Bioquímica, Portugal
1998 - 1998	Symposium “Update on bilirubin errors and new therapies”, 33rd Annual Meeting of the European Association for the Study of the Liver 1998, Lisbon, Portugal (1998 - 1998) Simpósio (Membro da Comissão Organizadora)	European Association for the Study of the Liver, Suiça