Luis Manuel Pires Ramalhete. works in the field(s) of Medical Sciences and Health with emphasis on Medical Biotechnology with a focus on Technologies involving the Manipulation of Cells, Tissues, Organs, or the entire Organism, Engineering Sciences and Technologies with an emphasis on Medical Engineering with a focus on Laboratory Technology (Histocompatibility and immunogenetics), and Medical Sciences and Health with an emphasis on Health Sciences. In curriculum Vitae, the most frequent terms in the context of scientific, technological, production are Histocompatibility, Machine Learning, Infrared spectroscopy. In the field Histocompatibility and immunogenetics provides or provided support in: On-call solid organ emergency team CSTL-T, performing all the immunological studies necessary to choose the best donor/recipient pair. FLOW CYTOMETRY LAB, Immunophenotyping in peripheral blood and bone marrow, Crossmatch, among others. IMMUNOGENETICS LAB, PCR-SSP, PCR-SSOP Luminex based assays, PCR-SSP with endpoint fluorescence detection, RT-PCR, and NGS for bone marrow donor’s registry and solid organ transplantation. CELL-MEDIATED IMMUNITY LAB, assessment of cellular responses between donor / recipient pairs in hematopoietic progenitors’ transplantation. HLA SEROLOGY LAB, Lab supervisor. As CSTL-T Histocompatibility and Immunogenetics Lab Director the main duties are: To define, in agreement with the guidelines from the Portuguese Transplantation Office the general operating policies of the laboratory for support of the transplantation programs. To be aware of and employ National Legislation and Guidelines on all stages of laboratory activity and management. To provide leadership and manage day-to-day operations of the H&I Lab. Responsible for ensuring the lab maintains the highest quality standards and compliance with regulatory bodies. To define the procedures and workflows to be used at each stage of histocompatibility testing as SOPs. Planning of a customized LIS for the different histocompatibility laboratories. To direct, train, supervise and evaluate all grades of laboratory staff including technical competences. To assign specific tasks to the technical staff. To decide in the public proposals for procurement of equipment and reagents for H&I testing and other procedures of the laboratory. To assign space and location to the technical staff, equipment, and distribute working areas according to requirement and GLP and EFI regulations. To improve methodologies in use and to introduce new methodologies. To review, validate and sign final reports. In absence, these are reviewed by technical supervisors. To provide advice and guidance to clinicians in the interpretation of HLA typing and alloreactivity profile results in the context of transplantation and diagnosis, providing them with sufficient information on test results to enable effective patient care. Provide information and advice to patients regarding transplant options. To supervise the performance of H&I testing including internal and external quality controls. To participate in risk management through error reporting and subsequent investigation through audit procedures. To review quality assurance and quality control data and take corrective action as needed. To decide the participation of the laboratory in collaborative schemes for quality control, reagent exchange and research on immunobiology and oncogenomics among others (Laboratório Engenharia & Saúde (ISEL) and Research Group on Stem Cell Engineering of the Institute of Bioengineering and Biosciences). To conceive and initiate research and development projects relevant to H&I. Establishing internal, national, and international professional relationships. Upon solicitation assist public and governmental organizations as expert in the field of transplantation, immunology.