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Jaakko Pohjoismäki. Completed the Doktor (PhD) in PhD, Molecular biology in 2008/02/14 by Tampereen yliopisto and Maisteri in Master of Science, Biology in 2002 by Itä-Suomen yliopisto. Is Senior researcher in University of Eastern Finland - Department of Environmental and Biological Sciences. Published 33 articles in journals. Supervised 1 PhD thesis(es). Has received 1 awards and/or honors. Participates and/or participated as Principal investigator in 3 project(s). Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Molecular Biology, Natural sciences with emphasis on Biological Sciences with emphasis on Cell Biology, Natural sciences with emphasis on Biological Sciences with emphasis on Genetics and Heredity, Natural sciences with emphasis on Biological Sciences with emphasis on Entomology and Natural sciences with emphasis on Biological Sciences with emphasis on Evolutionary Biology.
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Identificação

Identificação pessoal

Nome completo
Jaakko Pohjoismäki

Nomes de citação

  • Pohjoismäki, Jaakko

Identificadores de autor

Ciência ID
E71A-A6C7-0012
ORCID iD
0000-0002-1185-3610

Telefones

Telemóvel
  • (+358) 505744745 (Pessoal)

Moradas

  • Yliopistokatu 7, 80130, Joensuu, Joensuu, Finlândia (Profissional)

Websites

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Biologia Molecular
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Naturais - Ciências Biológicas - Genética e Hereditariedade
  • Ciências Naturais - Ciências Biológicas - Entomologia
  • Ciências Naturais - Ciências Biológicas - Biologia da Evolução das Espécies

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Finlandês (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Alemão Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B2) Utilizador independente (B1)
Sueco Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B1) Utilizador independente (B2) Utilizador independente (B1)
Formação
Grau Classificação
2008/02/14
Concluído
 PhD, Molecular biology (Doktor (PhD))
Tampereen yliopisto, Finlândia
2002
Concluído
 Master of Science, Biology (Maisteri)
Especialização em Ecology, minor in molecular biology and biochemistry
Itä-Suomen yliopisto, Finlândia
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2010/05/01 - 2012/07/31 Pós-doutorado (Investigação) Max-Planck-Institut für Herz- und Lungenforschung W G Kerckhoff-Institute, Alemanha
2008/04/01 - 2010/04/30 Pós-doutorado (Investigação) Tampereen yliopisto Lääketieteen yksikkö, Finlândia
2002/04/01 - 2008/03/31 Investigador (Investigação) Tampereen yliopisto Biolääketieteellisen teknologian yksikkö, Finlândia

Cargos e Funções

Categoria Profissional
Instituição de acolhimento 		Empregador
2012/08/01 - Atual Senior researcher University of Eastern Finland - Department of Environmental and Biological Sciences, Finlândia
University of Eastern Finland - Department of Environmental and Biological Sciences, Finlândia
Projetos

Bolsa

Designação Financiadores
2020/01 - 2023/12 Genomic compatibility as the backstop at the species boundary
329264
 Suomen Akatemia
2019/09 - 2021/08 True love can wait: Breaking genetic abstinence to repair mitochondrial DNA using recombination
325015
 Suomen Akatemia
2016/10/01 - 2019/09/30 Mitochondrial hormesis in the maintenance of cell health
1-2016
Investigador responsável
Itä-Suomen yliopisto, Finlândia
Concluído
2018/09/01 - 2019/08/31 The Polluted Brain: Interaction of Air Pollution and Mitochondrial Function in Alzheimer’s disease
-
Investigador responsável
Itä-Suomen yliopisto Biologian laitos, Finlândia
Concluído
2017/09/01 - 2018/09/01 Elucidating the species boundaries in the highly diverse genus Gymnosoma (Diptera: Tachinidae) using ddRAD.
SUB.2017.05.09
Investigador responsável
Concluído
2013/10/01 - 2016/09/30 The molecular mechanisms of mtDNA recombination and their role in oxidative damage response in mammalian heart mitochondria
1-2013
Investigador responsável
2010/04 - 2012/05 Mitochondrial DNA recombination in mammalian heart muscle
ALTF 1125-2009
 Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH
Produções

Publicações

Artigo em revista
  1. Rubén Torregrosa-Muñumer; Anu Hangas; Steffi Goffart; Daniel Blei; Gábor Zsurka; Jack Griffith; Wolfram S. Kunz; Jaakko L. O. Pohjoismäki. "Replication fork rescue in mammalian mitochondria". Scientific Reports (2019): https://doi.org/10.1038/s41598-019-45244-6.
    10.1038/s41598-019-45244-6
  2. Pohjoismäki, Jaakko. "Twist and Turn—Topoisomerase Functions in Mitochondrial DNA Maintenance". International Journal of Molecular Sciences (2019): http://dx.doi.org/10.3390/ijms20082041.
    10.3390/ijms20082041
  3. Anu Hangas; Koit Aasumets; Nina J Kekäläinen; Mika Paloheinä; Jaakko L Pohjoismäki; Joachim M Gerhold; Steffi Goffart. "Ciprofloxacin impairs mitochondrial DNA replication initiation through inhibition of Topoisomerase 2". Nucleic Acids Research 46 18 (2018): 9625-9636. https://doi.org/10.1093%2Fnar%2Fgky793.
    10.1093/nar/gky793
  4. Jaakko L. O. Pohjoismäki; Arnar Palsson; Sara Lampi; Jonas Donner; Heidi Anderson. "Origins and wanderings of the Finnish hunting spitzes". PLOS ONE (2018): https://doi.org/10.1371/journal.pone.0199992.
    10.1371/journal.pone.0199992
  5. Riikka Levänen; Riccardo Castiglia; Carl-Gustaf Thulin; Göran Spong; Jaakko L. O. Pohjoismäki. "Widespread introgression of mountain hare genes into Fennoscandian brown hare populations". PLOS ONE (2018): https://doi.org/10.1371/journal.pone.0191790.
    10.1371/journal.pone.0191790
  6. Elena Herbers; Nina J. Kekäläinen; Anu Hangas; Jaakko L. Pohjoismäki; Steffi Goffart. "Tissue specific differences in mitochondrial DNA maintenance and expression". Mitochondrion (2018): https://doi.org/10.1016%2Fj.mito.2018.01.004.
    10.1016/j.mito.2018.01.004
  7. Rubén Torregrosa-Muñumer; Josefin M. E. Forslund; Steffi Goffart; Annika Pfeiffer; Gorazd Stojkovic; Gustavo Carvalho; Natalie Al-Furoukh; et al. "PrimPol is required for replication reinitiation after mtDNA damage". Proceedings of the National Academy of Sciences 114 43 (2017): 11398-11403. https://doi.org/10.1073/pnas.1705367114.
    10.1073/pnas.1705367114
  8. M. Kumpulainen; H. Anderson; T. Svevar; I. Kangasvuo; J. Donner; J. Pohjoismäki. "Founder representation and effective population size in old versus young breeds-genetic diversity of Finnish and Nordic Spitz". Journal of Animal Breeding and Genetics 134 5 (2017): 422-433. https://doi.org/10.1111%2Fjbg.12262.
    10.1111/jbg.12262
  9. Jaakko L. Pohjoismäki; Steffi Goffart. "The role of mitochondria in cardiac development and protection". Free Radical Biology and Medicine 106 (2017): 345-354. https://doi.org/10.1016%2Fj.freeradbiomed.2017.02.032.
    10.1016/j.freeradbiomed.2017.02.032
  10. Diego J. Inclán; Giuseppe Lo Giudice; John O. Stireman III; Pierfilippo Cerretti; Hiroshi Shima; James E. O’Hara; Jaakko Pohjoismäki. "The monophyly of the Glaurocarini (Diptera: Tachinidae: Tachininae) with the description of a new species of Semisuturia from Australia". Insect Systematics & Evolution (2017): https://doi.org/10.1163%2F1876312x-48022157.
    10.1163/1876312x-48022157
  11. Jaakko L. O. Pohjoismäki; Claude Wicker-Thomas; Jere Kahanpää; Marko Mutanen. "DNA Barcodes for the Northern European Tachinid Flies (Diptera: Tachinidae)". PLOS ONE 11 11 (2016): e0164933-e0164933. https://doi.org/10.1371%2Fjournal.pone.0164933.
    10.1371/journal.pone.0164933
  12. Torregrosa-Muñumer R; Goffart S; Haikonen JA; Pohjoismäki JL. "Low doses of ultraviolet radiation and oxidative damage induce dramatic accumulation of mitochondrial DNA replication intermediates, fork regression, and replication initiation shift.". (2015): http://europepmc.org/abstract/med/26399294.
    10.1091/mbc.E15-06-0390
  13. Wirta H; Várkonyi G; Rasmussen C; Kaartinen R; Schmidt NM; Hebert PD; Barták M; et al. "Establishing a community-wide DNA barcode library as a new tool for arctic research.". (2015): http://europepmc.org/abstract/med/26602739.
  14. R. Torregrosa-Munumer; S. Goffart; J. A. Haikonen; J. L. O. Pohjoismaki. "Low doses of ultraviolet radiation and oxidative damage induce dramatic accumulation of mitochondrial DNA replication intermediates, fork regression, and replication initiation shift". Molecular Biology of the Cell 26 23 (2015): 4197-4208. https://doi.org/10.1091%2Fmbc.e15-06-0390.
    10.1091/mbc.e15-06-0390
  15. Pohjoismäki J; Haarto A. "Linnaemya bergstroemi n. sp. (Diptera: Tachinidae)-a new parasitoid fly from the Finnish Lapland.". (2015): http://europepmc.org/abstract/med/26701580.
    10.11646/zootaxa.4059.3.9
  16. Pohjoismäki J; Kahanpää J. "Checklist of the superfamilies Oestroidea and Hippoboscoidea of Finland (Insecta, Diptera).". (2014): http://europepmc.org/abstract/med/25337034.
    10.3897/zookeys.441.7252
  17. Pohjoismäki JL; Williams SL; Boettger T; Goffart S; Kim J; Suomalainen A; Moraes CT; Braun T. "Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species.". (2013): http://europepmc.org/abstract/med/24218554.
    10.1073/pnas.1303046110
  18. Pohjoismäki JL; Krüger M; Al-Furoukh N; Lagerstedt A; Karhunen PJ; Braun T. "Postnatal cardiomyocyte growth and mitochondrial reorganization cause multiple changes in the proteome of human cardiomyocytes.". (2013): http://europepmc.org/abstract/med/23459711.
    10.1039/c3mb25556e
  19. Pohjoismäki JL; Boettger T; Liu Z; Goffart S; Szibor M; Braun T. "Oxidative stress during mitochondrial biogenesis compromises mtDNA integrity in growing hearts and induces a global DNA repair response.". (2012): http://europepmc.org/abstract/med/22508755.
    10.1093/nar/gks301
  20. J. L. O. Pohjoismaki. "Letter by Pohjoismaki Regarding Article, "Impaired Mitochondrial Biogenesis Precedes Heart Failure in Right Ventricular Hypertrophy in Congenital Heart Disease"". Circulation: Heart Failure 5 1 (2012): e15-e15. https://doi.org/10.1161%2Fcircheartfailure.111.964502.
    10.1161/circheartfailure.111.964502
  21. Pohjoismäki JL. "Letter by Pohjoismaki regarding article, "Impaired mitochondrial biogenesis precedes heart failure in right ventricular hypertrophy in congenital heart disease".". (2012): http://europepmc.org/abstract/med/22253409.
    10.1161/CIRCHEARTFAILURE.111.964502
  22. Pohjoismäki JL; Goffart S; Spelbrink JN. "Replication stalling by catalytically impaired Twinkle induces mitochondrial DNA rearrangements in cultured cells.". (2011): http://europepmc.org/abstract/med/21540127.
    10.1016/j.mito.2011.04.002
  23. Pohjoismäki JL; Goffart S. "Of circles, forks and humanity: Topological organisation and replication of mammalian mitochondrial DNA.". (2011): http://europepmc.org/abstract/med/21290399.
    10.1002/bies.201000137
  24. Hyvärinen AK; Pohjoismäki JL; Holt IJ; Jacobs HT. "Overexpression of MTERFD1 or MTERFD3 impairs the completion of mitochondrial DNA replication.". (2011): http://europepmc.org/abstract/med/20577816.
    10.1007/s11033-010-0233-9
  25. Pohjoismäki JL; Karhunen PJ; Goebeler S; Saukko P; Sääksjärvi IE. "Indoors forensic entomology: colonization of human remains in closed environments by specific species of sarcosaprophagous flies.". (2010): http://europepmc.org/abstract/med/20304573.
    10.1016/j.forsciint.2010.02.033
  26. Pohjoismäki JL; Holmes JB; Wood SR; Yang MY; Yasukawa T; Reyes A; Bailey LJ; et al. "Mammalian mitochondrial DNA replication intermediates are essentially duplex but contain extensive tracts of RNA/DNA hybrid.". (2010): http://europepmc.org/abstract/med/20184890.
    10.1016/j.jmb.2010.02.029
  27. J. Bradley Holmes; Jaakko L.O. Pohjoismäki; Ming-Yao Yang; Takehiro Yasukawa; Tricia J. Cluett; Aurelio Reyes; Steffi Goffart; et al. "89 Analysis of extensive RNA/DNA hybrids in the replicating mammalian mitochondrial genome". Mitochondrion 10 2 (2010): 225-225. https://doi.org/10.1016%2Fj.mito.2009.12.082.
    10.1016/j.mito.2009.12.082
  28. Pohjoismäki JL; Goffart S; Taylor RW; Turnbull DM; Suomalainen A; Jacobs HT; Karhunen PJ. "Developmental and pathological changes in the human cardiac muscle mitochondrial DNA organization, replication and copy number.". (2010): http://europepmc.org/abstract/med/20454654.
    10.1371/journal.pone.0010426
  29. Pohjoismäki JL; Goffart S; Tyynismaa H; Willcox S; Ide T; Kang D; Suomalainen A; et al. "Human heart mitochondrial DNA is organized in complex catenated networks containing abundant four-way junctions and replication forks.". (2009): http://europepmc.org/abstract/med/19525233.
    10.1074/jbc.M109.016600
  30. Jaakko L. O. Pohjoismäki; Steffi Goffart; Henna Tyynismaa; Smaranda Willcox; Tomomi Ide; Dongchon Kang; Anu Suomalainen; et al. "Human Heart Mitochondrial DNA Is Organized in Complex Catenated Networks Containing Abundant Four-way Junctions and Replication Forks". Journal of Biological Chemistry 284 32 (2009): 21446-21457. https://doi.org/10.1074%2Fjbc.m109.016600.
    10.1074/jbc.m109.016600
  31. Wanrooij S; Goffart S; Pohjoismäki JL; Yasukawa T; Spelbrink JN. "Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes.". (2007): http://europepmc.org/abstract/med/17452351.
    10.1093/nar/gkm215
  32. Hyvärinen AK; Pohjoismäki JL; Reyes A; Wanrooij S; Yasukawa T; Karhunen PJ; Spelbrink JN; Holt IJ; Jacobs HT. "The mitochondrial transcription termination factor mTERF modulates replication pausing in human mitochondrial DNA.". (2007): http://europepmc.org/abstract/med/17884915.
    10.1093/nar/gkm676
  33. Pohjoismäki JL; Wanrooij S; Hyvärinen AK; Goffart S; Holt IJ; Spelbrink JN; Jacobs HT. "Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells.". (2006): http://europepmc.org/abstract/med/17062618.
    10.1093/nar/gkl703

Outros

Outra produção
  1. Shortcutting evolution through adaptive hybridization in hares. 2019. Pohjoismäki, Jaakko. http://rgdoi.net/10.13140/RG.2.2.31899.92960.
    10.13140/RG.2.2.31899.92960
Atividades

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2020/03/01 - Atual Genomic compatibility as a backstop in species differentiation
Orientador
 Evolutionary genomics
2018/01/01 - Atual Adaptive introgression in brown hare
Orientador
University of Eastern Finland - Department of Environmental and Biological Sciences, Finlândia
2017/01/01 - Atual Resolving deep divergences and rapid radiations in the order Hymenoptera
Coorientador
University of Eastern Finland - Department of Environmental and Biological Sciences, Finlândia
2015/01/01 - Atual Topoisomerases 2 and 3 in mitochondrial DNA maintenance
Coorientador
 Molecular biology
2014/01/01 - 2019/03/31 Coexistence of northern hares : consequences of crossbreeding and changing climate
Orientador
 Ecological genetics
University of Eastern Finland - Department of Environmental and Biological Sciences, Finlândia
2013/10/01 - 2018/09/26 Replication stress and damage tolerance in mammalian mitochondria
Orientador
 Molecular biology (Doutoramento)
University of Eastern Finland - Department of Environmental and Biological Sciences, Finlândia
Distinções

Prémio

2016 Teacher of the year
University of Eastern Finland - Department of Environmental and Biological Sciences, Finlândia