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Maria João Arez completed her bachelor’s degree in biology at Faculdade de Ciências da Universidade de Lisboa in 2016. She then pursued an MSc in Molecular Genetics and Biomedicine at the Faculdade de Ciências e Tecnologia da Universidade Nova de Lisboa, completed in 2018. During her thesis year at the Instituto de Medicina Molecular | João Lobo Antunes (iMM|JLA), she gained her first experience in DNA methylation, Genomic Imprinting, and Stem Cells. Following her master's, she was awarded a research fellowship to continue her project as a research technician, further deepening her knowledge in this field. In 2020, she undertook a four-month internship in Prof. Simon Hippenmeyer Lab at the Institute of Science and Technology Austria (IST Austria), where she established an in vitro model of cortical neurons derived from Cdkn1c conditional knockout mouse embryonic stem cells, an experience that reinforced her decision to pursue a PhD. In 2021, she returned to Portugal to continue her research on Genomic Imprinting and Stem Cells and began her PhD in Bioengineering, specialization in Cellular Therapy and Regenerative Medicine at the Institute for Bioengineering and Biosciences (iBB) at Instituto Superior Técnico (IST Lisbon). Her research has yielded significant findings, leading to a first-author publication in Nature Communications in 2022, where she reported key results on Genomic Imprinting fidelity in mouse stem cells. Currently, her PhD work focuses on Genomic Imprinting in human stem cells. In the final year of her PhD, she was awarded the Prémio Maria de Sousa to support her first independent project, which aims to develop a novel reprogramming strategy to generate human induced pluripotent stem cells (iPSCs) free of imprinting defects. Throughout her PhD, Maria has actively participated in national and international conferences, presenting her work through oral presentations and posters. Notably, she recently presented her latest findings at the largest stem cell conference, where established key collaborations with researchers in the field.
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Identificação

Identificação pessoal

Nome completo
Maria João Arez

Nomes de citação

  • Arez, Maria

Identificadores de autor

Ciência ID
F71B-A234-1AA7
ORCID iD
0000-0001-5564-3490

Endereços de correio eletrónico

  • maria.arez@tecnico.ulisboa.pt (Profissional)

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador independente (B1) Utilizador proficiente (C1) Utilizador independente (B2) Utilizador independente (B2)
Formação
Grau Classificação
2021/04/05 - 2024
Em curso
 PhD in Bioengeneering - Specialty of Cellular Therapy and Regenerative Medicine (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico Campus Taguspark, Portugal
2019/09/26 - 2019/12/31
Concluído
 Scientific Writing "Structuring and writing a hypothesis-driven research paper" (Outros)
Instituto de Medicina Molecular, Portugal
 97%
2019/06/17 - 2019/07/31
Concluído
 CONGENTO Course on Laboratory Animal Science (EU, Function A) (Diploma de especialização)
Instituto de Medicina Molecular, Portugal
 Aproved
2016/09/06 - 2018/10/23
Concluído
 Genética Molecular e Biomedicina (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Comprehensive Evaluation of Genomic Imprinting Stability in Mouse iPSCs" (TESE/DISSERTAÇÃO)
 17
2013/09/06 - 2016/07/06
Concluído
 Biologia (Licenciatura)
Especialização em Biologia Molecular e Genética
Universidade de Lisboa Faculdade de Ciências, Portugal
 16
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/04/05 - Atual Investigador (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Lisboa Instituto Superior Técnico Campus Taguspark, Portugal
2021/01/01 - 2021/03/31 Investigador (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
Instituto de Medicina Molecular, Portugal
2020/09/15 - 2020/12/31 Estagiário de Investigação (Investigação) Institute of Science and Technology Austria, Áustria
Institute of Science and Technology Austria, Áustria
2019/01/07 - 2020/08/31 Investigador (Investigação) Fundação para a Ciência e a Tecnologia, Portugal
Instituto de Medicina Molecular, Portugal
2017/09/23 - 2018/10/23 Estagiário de Investigação (Investigação) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Instituto de Medicina Molecular, Portugal
2016/02/20 - 2016/07/06 Estagiário de Investigação (Investigação) Universidade de Lisboa Faculdade de Ciências, Portugal
Universidade de Lisboa - Tec Labs Centro de Inovação, Portugal
Projetos

Outro

Designação Financiadores
2021/04/05 - Atual Assessing the impact of imprinting defects in human iPSCs: Is cell therapy safe?
UI/BD/151251/2021
Bolseiro de Doutoramento
Em curso
2019/01/07 - 2021/03/31 The aging epigenetic barriers in cell reprogramming
PTDC/BIA-MOL/29320/2017
Bolseiro de Mestrado
Instituto de Medicina Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
Produções

Publicações

Artigo em revista
  1. Raposo, Ana Cláudia; Caldas, Paulo; Arez, Maria; Jeremias, Joana; Barbosa, Pedro; Rui Sousa-Luís; Água, Frederico; et al. "Erosion of X-Chromosome Inactivation in female hiPSCs is heterogeneous and persists during differentiation". BioRvix (2025):
    Em revisão • https://doi.org/10.1101/2024.03.15.585169
  2. Arez, Maria; Eckersley-Maslin, Melanie; Klobucar, Tajda; von Gilsa Lopes, João; Krueger, Felix; Mupo, Annalisa; Raposo, Ana Cláudia; et al. "Imprinting fidelity in mouse iPSCs depends on sex of donor cell and medium formulation". Nature Communications 13 1 (2022): https://doi.org/10.1038/s41467-022-33013-5.
    Publicado • 10.1038/s41467-022-33013-5
  3. Silva, Teresa P.; Pereira, Carolina A.; Raposo, Ana Cláudia; Oliveira, Ana Rita; Arez, Maria; Cabral, Joaquim M.S.; Milagre, Inês; Carmo-Fonseca, Maria; Rocha, Simão Teixeira da. "Generation and characterization of induced pluripotent stem cells heterozygous for the Portuguese BRCA2 founder mutation". Stem Cell Research 53 (2021): 102364. http://dx.doi.org/10.1016/j.scr.2021.102364.
    Publicado • 10.1016/j.scr.2021.102364
  4. Silva, Teresa P.; Pereira, Carolina A.; Oliveira, Ana Rita; Raposo, Ana Cláudia; Arez, Maria; Cabral, Joaquim M.S.; Milagre, Inês; Carmo-Fonseca, Maria; da Rocha, Simão T.. "Generation and characterization of induced pluripotent stem cells from a family carrying the BRCA1 mutation c.3612delA". Stem Cell Research 52 (2021): 102242. http://dx.doi.org/10.1016/j.scr.2021.102242.
    Publicado • 10.1016/j.scr.2021.102242
  5. Klobucar, Tajda; Kreibich, Elisa; Krueger, Felix; Arez, Maria; Pólvora-Brandão, Duarte; von Meyenn, Ferdinand; da Rocha, Simão Teixeira; Eckersley-Maslin, Melanie. "IMPLICON: an ultra-deep sequencing method to uncover DNA methylation at imprinted regions". Nucleic Acids Research 48 16 (2020): e92-e92. http://dx.doi.org/10.1093/nar/gkaa567.
    Publicado • 10.1093/nar/gkaa567
Poster em conferência
  1. Arez, Maria; Caldas, Paulo; Sansone, Melissa; Oxley, David; da Rocha, Simão T.. "How do imprints cope during reprogramming of female and male human iPSCs?". Trabalho apresentado em ISSCR 2024 Annual Meeting, 2024.
  2. Arez, Maria; Gouveia, Maria; Raposo, Ana Cláudia; Krueger, Felix; Mupo, Annalisa; Eckersley-Maslin, Melanie; da Rocha, Simão T.. "Why is genomic imprinting dysregulated during reprogramming of iPSCs?". Trabalho apresentado em Genomic Imprinting 2023, 2023.
  3. Arez, Maria; Eckersley-Maslin, Melanie; Klobucar, Tajda; von Gilsa Lopes, João; Krueger, Felix; Mupo, Annalisa; Raposo, Ana Cláudia; et al. "Sex of donor cell and medium formulation as predictors of imprinting disruption in mouse iPSCs". Trabalho apresentado em 6th Max Planck Epigenetics Meeting 2022, 2022.
  4. Arez, Maria; Eckersley-Maslin, Melanie; Von Gilsa, João; GENDREL, ANNE-VALERIE; Raposo, Ana; Bernardes de Jesus, Bruno; da Rocha, Simão T.. "Comprehensive Evaluation of Genomic Imprinting Stability in Mouse iPSCs". Trabalho apresentado em 11th Edition of the International Meeting of the Portuguese Society for Stem Cells & Cell Therapies, 2019.
Resumo em conferência
  1. Arez, Maria. "Comprehensive Evaluation of Genomic Imprinting Stability in Mouse iPSCs". Trabalho apresentado em SPCE-TC 2019 – 11th Edition of the International Meeting of the Portuguese Society for Stem Cells & Cell Therapies, Lisbon, 2019.
    Publicado
Tese / Dissertação
  1. Arez, Maria. "Comprehensive Evaluation of Genomic Imprinting Stability in Mouse iPSCs". Mestrado, Instituto de Medicina Molecular, 2018.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022/03/10 Systematic analysis of imprinting defects in murine iPSCs 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
SPCE-TC (Braga, Portugal)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2025/01/24 - 2025/01/24 Workshop on LaTeX
Oficina (workshop)
 Workshop of LaTeX
Universidade de Lisboa Instituto Superior Técnico, Portugal
2024/04/23 - 2024/04/23 Workshop on "How to design a graphical abstract"
Oficina (workshop)
 How to design a graphical abstract
Universidade de Lisboa Instituto Superior Técnico, Portugal
2024/04/15 - 2024/04/16 Course on Scientific Communication. Included 56h of theoretical and practical classes.
Universidade de Lisboa, Portugal
2019/09/26 - 2019/12/31 Scientific Writing Course. I wrote a full hypothesis-driven research paper according to the IMRAD (Introduction, Material and Methods, Results and Discussion) format. I also learnt the steps involved in producing and publishing a research paper and how to use the language (English) in order to produce an article that effectively conveys its message.
Outro
 Scientific Writing “Structuring and writing a hypothesis-driven research paper”
Instituto de Medicina Molecular, Portugal
2019/12/02 - 2019/12/05 EMBL Course: Enzymatic Methyl-seq: Bisulfite-Free Methylation Analysis. Prepared and analysed "bisulfite-free" methylome libraries for Illumina sequencing using a novel enzymatic approach to detect 5-methyl cytosines that results in longer reads and higher coverage of genomic features at lower minimum coverage thresholds when compared to Illumina bisulfite libraries.
Outro
 EMBL Course: Enzymatic Methyl-seq: Bisulfite-Free Methylation Analysis
EMBL Heidelberg Genome Biology, Alemanha
2019/06/17 - 2019/07/31 CONGENTO Course on Laboratory Animal Science. Included 20h of theoretical course in laboratory animal science as recommended by FELASA (category B) which was complemented with pratical training of rodents and zebrafish.
Outro
 CONGENTO Course on Laboratory Animal Science (EU, Function A)
Instituto de Medicina Molecular, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2024/03/01 - 2024/05/01 Engenharia de Células e Tecidos. Teaching of practical classes Engenharia de Células e Tecidos (Licenciatura) Universidade de Lisboa Instituto Superior Técnico, Portugal

Tutoria

Tópico Nome do aluno
2024/03/12 - 2024/07/12 Laboratorial Supervision João Severino
2023/02/01 - 2023/07/28 Laboratorial Supervision Melissa Sansone
2019/05/07 - 2019/08/07 Laboratorial Supervision Tajda Klobucar
2018/07/10 - 2018/08/10 Techniques teaching Patrícia Quelhas
Distinções

Prémio

2024 Prémio Maria de Sousa Award
Fundação Bial, Portugal

Ordem dos Médicos, Portugal