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Throughout my academic journey, I have continuously strived to advance my knowledge and skills in the field of Biotechnology. In 2017 I started my master's degree in industrial biotechnology at Milano-Bicocca, which is broadly recognized as one of the top 3 universities for biotechnology science in Italy. During my studies, I excelled in the nanotechnology class, which earned me an internship at Mario Negri Institute (IT), a leading research institution in northern Italy. Here, I worked on the topic of NPs for oral delivery in an animal model. My work resulted in a master's thesis and my first publication. Overall, I gained valuable laboratory experience in the synthesis, biodistribution, accumulation, and clearance of NPs in living systems (both cells and mice) leveraging techniques for cellular and molecular biology and animal model handling. Active participation in various research group projects and international collaborations, including those with the Flemish Institute for Technological Research (BE) and Pharmazentrum Frankfurt/ZAFES (DE), resulted in 2 additional publications. Alongside this, I mentored 2 bachelor students, honing my supervision skills, and presented my work at conferences hosted by Politecnico of Milan (IT) and the University of Turin (IT). Finally, I was involved in the collaboration between Mario Negri and Bracco company which aimed to investigate the neuro-nanotoxicity of TiO2 NPs. This experience allowed me to expand my knowledge and abilities in line with both the research group's and the company's goals. Driven by the desire for international exposure and personal growth, I applied for a Ph.D. in Portugal and received the FCT Ph.D. grant under the Tissue Engineering, Regenerative Medicine, and Stem Cells program from 3B's Research Group (University of Minho). In the context of my Ph.D. project, I developed and implemented an innovative technology in the research institute, based on microfluidic micromixing for the controlled synthesis of NPs. This groundbreaking approach had not been explored by any researcher at 3B's Research Group before and has opened multiple new possibilities for investigation. Overall, the work developed resulted in 5 original scientific works and 1 comprehensive review paper, all as first author. Furthermore, I took part in the Laboratory Animal Science course at the University of Minho, which I successfully completed. As a result, I obtained the Federation of European Laboratory Animal Science Associations (FELASA). This certification is essential for my experimental approach as it enables me to conduct experiments on models with increasing levels of complexity, ranging from in-vitro to in-vivo studies. In addition, I played an active role in various group projects that entailed collaborations with both internal and external partners such as the University of Porto and the University of Coimbra. These endeavors led to the creation of 4 original works (2 under revision). Moreover, I supervised 2 master's students and I participated in 15+ international conferences which improved both my mentoring and communicational skills. I then concluded my path in April 2023 when I defended my Ph.D. thesis entitled "Development of Polymeric Nanoparticles by Microfluidic Technologies as Functional Drug Delivery Devices", being unanimously approved as a Ph.D. with the maximum grade of Very Good. Shortly after, by the end of 2023, I was awarded a six-years grant for a junior researcher position (CEEC-Ind, Individual Call to Scientific Employment Stimulus from Fundação para a Ciência e a Tecnologia).
Identificação

Identificação pessoal

Nome completo
Sara Gimondi
Data de nascimento
1993/09/04

Nomes de citação

  • Gimondi, Sara

Identificadores de autor

Ciência ID
F812-6E8A-16E8
ORCID iD
0000-0002-6660-0477
Researcher Id
Q-3738-2018
Scopus Author Id
60029411

Endereços de correio eletrónico

  • sara.gimondi@i3bs.uminho.pt (Profissional)

Moradas

  • AvePark - Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Guimarães, Guimarães, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências da Engenharia e Tecnologias - Biotecnologia Industrial - Biotecnologia Industrial
  • Ciências da Engenharia e Tecnologias - Nanotecnologia - Nanomateriais
  • Ciências da Engenharia e Tecnologias - Nanotecnologia - Nanoprocessos
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Italiano (Idioma materno)
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Português Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2018/09/01 - 2023/04/20
Concluído
Tissue Engineering, Regenerative Medicine and Stem Cells (Doutoramento)
Universidade do Minho, Portugal
"Development of Polymeric Nanoparticles by Microfluidic Technologies as Functional Drug Delivery Devices" (TESE/DISSERTAÇÃO)
Very good
2015/10/01 - 2018/02/28
Concluído
Industrial Biotechnology (Laurea Magistrale)
Universita degli Studi di Milano-Bicocca Dipartimento di Biotecnologie e Bioscienze, Itália
"Stability and biodistribution of poly(lactic-co-glycolic acid) nanoparticles (PLGA) after oral administration in healthy mice" (TESE/DISSERTAÇÃO)
19
2012/10/01 - 2015/04/01
Concluído
Biotechnology (Bachelor)
Universita degli Studi di Milano-Bicocca Dipartimento di Biotecnologie e Bioscienze, Itália
"Glyco-functionalized nanoparticles for glioma treatment " (TESE/DISSERTAÇÃO)
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento
Empregador
2018/09/01 - Atual Investigador (Investigação) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Biomaterials Biodegradables and Biomimetics, Portugal
Projetos

Bolsa

Designação Financiadores
2022/11/01 - 2023/01/31 FCT COVID19 Grant
COVID/BD/152016/2021
Bolseiro de Doutoramento
2018/12/01 - 2022/10/31 FCT PhD Scholarship
PD/BD/135253/2017
Bolseiro de Doutoramento
2018/09/01 - 2022/08/31 PATH (FCT Doctoral Program on Advanced Therapies for Health)
Bolseiro de Doutoramento
Biomaterials Biodegradables and Biomimetics, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal
Em curso
2018/09 - 2018/12 FLEXPOL
721062
Bolseiro de Investigação
Concluído

Projeto

Designação Financiadores
2024 - 2030 CEEC Individual - A Multi-Organ-on-a-Chip Platform for Comprehensive Study of Colorectal Cancer Metastasis and Screening of Targeted Nanoparticles
2023.06754.CEECIND
Bolseiro de Pós-Doutoramento
Em curso
2023/11 - 2024/11 APTADEGRAD - A novel, pioneering aptamer-based LYTACs to address the unmet clinical needs of diabetic wounds
Bolseiro de Pós-Doutoramento
Biomaterials Biodegradables and Biomimetics, Portugal
Horizon Europe
Em curso
Produções

Publicações

Artigo em revista
  1. Sara Gimondi; Helena Ferreira; Rui L. Reis; Nuno M. Neves. "Intracellular Trafficking of Size-Tuned Nanoparticles for Drug Delivery". International Journal of Molecular Sciences (2023): http://dx.doi.org/10.3390/ijms25010312.
    10.3390/ijms25010312
  2. D. Mendanha; S. Gimondi; B.M. Costa; H. Ferreira; N.M. Neves. "Microfluidic-derived docosahexaenoic acid liposomes for glioblastoma therapy". Nanomedicine: Nanotechnology, Biology and Medicine (2023): 102704-102704. http://dx.doi.org/10.1016/j.nano.2023.102704.
    10.1016/j.nano.2023.102704
  3. Sara Gimondi; Helena Ferreira; Rui L. Reis; Nuno M. Neves. "Microfluidic Devices: A Tool for Nanoparticle Synthesis and Performance Evaluation". ACS Nano (2023): https://doi.org/10.1021/acsnano.3c01117.
    10.1021/acsnano.3c01117
  4. Sara Gimondi; Joana Vieira de Castro; Rui L. Reis; Helena Ferreira; Nuno M. Neves. "On the size-dependent internalization of sub-hundred polymeric nanoparticles". Colloids and Surfaces B: Biointerfaces 225 (2023): 113245-113245. http://dx.doi.org/10.1016/j.colsurfb.2023.113245.
    10.1016/j.colsurfb.2023.113245
  5. Sara Gimondi; Helena Ferreira; Rui L. Reis; Nuno M. Neves. "Size-Dependent Polymeric Nanoparticle Distribution in a Static versus Dynamic Microfluidic Blood Vessel Model: Implications for Nanoparticle-Based Drug Delivery". ACS Applied Nano Materials (2023): https://doi.org/10.1021/acsanm.3c00481.
    10.1021/acsanm.3c00481
  6. D. Mendanha; J. Vieira de Castro; M.R. Casanova; S. Gimondi; H. Ferreira; N.M. Neves. "Macrophage cell membrane infused biomimetic liposomes for glioblastoma targeted therapy". Nanomedicine: Nanotechnology, Biology and Medicine 49 (2023): 102663-102663. http://dx.doi.org/10.1016/j.nano.2023.102663.
    10.1016/j.nano.2023.102663
  7. Sara Gimondi; Rui L. Reis; Helena Ferreira; Nuno M. Neves. "Microfluidic-driven mixing of high molecular weight polymeric complexes for precise nanoparticle downsizing". Nanomedicine: Nanotechnology, Biology and Medicine 43 (2022): 102560-102560. http://dx.doi.org/10.1016/j.nano.2022.102560.
    10.1016/j.nano.2022.102560
  8. Gimondi, Sara. "Microfluidic mixing system for precise PLGA-PEG nanoparticles size control". Nanomedicine: Nanotechnology, Biology and Medicine 40 (2021): 102482-102482. http://dx.doi.org/10.1016/j.nano.2021.102482.
    10.1016/j.nano.2021.102482
  9. Morelli, Lucia; Gimondi, Sara; Sevieri, Marta; Salvioni, Lucia; Guizzetti, Maria; Colzani, Barbara; Palugan, Luca; et al. "Monitoring the Fate of Orally Administered PLGA Nanoformulation for Local Delivery of Therapeutic Drugs". Pharmaceutics 11 12 (2019): 658. http://dx.doi.org/10.3390/pharmaceutics11120658.
    10.3390/pharmaceutics11120658
  10. Talamini, Laura; Gimondi, Sara; Violatto, Martina Bruna; Fiordaliso, Fabio; Pedica, Federica; Lan Tran, Ngoc ; Sitia, Giovanni; et al. "Repeated administration of the food additive E171 to mice results in accumulation in intestine and liver and promotes an inflammatory status". Nanotoxicology (2019): http://dx.doi.org/10.1080/17435390.2019.1640910.
    10.1080/17435390.2019.1640910
  11. Violatto, Martina Bruna; Casarin, Elisabetta; Talamini, Laura; Russo, Luca; Baldan, Simone; Tondello, Camilla; Messmer, Marie; et al. "Dexamethasone Conjugation to Biodegradable Avidin-Nucleic-Acid-Nano-Assemblies Promotes Selective Liver Targeting and Improves Therapeutic Efficacy in an Autoimmune Hepatitis Murine Model". (2019): http://dx.doi.org/10.1021/acsnano.8b09655.
    10.1021/acsnano.8b09655
Poster em conferência
  1. Gimondi, Sara. "Tailoring Nanoparticle Design for Enhanced Cell Targeting: The Impact of Size on Uptake Mechanisms". Trabalho apresentado em HEALTH-UNORTE -TERM STEM 2023, 2023.
  2. Gimondi, Sara. "Microfluidic synthesis of size-controlled nanoparticles for anti-inflammatory applications". Trabalho apresentado em TERM STEM 2022, 2022.
  3. Gimondi, Sara. "Microfluidic-driven synthesis of size-controlled nanoparticles for anti-inflammatory purposes". Trabalho apresentado em Third Achilles Workshop, 2021.
  4. Gimondi, Sara. "Fine Tuning Nanoparticle Precipitation with a Microfluidic Mixer for Modulating NSAIDs Delivery". Trabalho apresentado em Final FoReCaST Conference, 2021.
  5. Gimondi, Sara. "Fine Tuning Nanoparticle Precipitation with a Microfluidic Mixer for Modulating NSAIDs Delivery". Trabalho apresentado em TERM STEM 2021, 2021.
  6. Gimondi, Sara. "Microfluidic Mixing System for the Production of Tunable Nanoparticles". Trabalho apresentado em TERM STEM 2019, 2019.
  7. Gimondi, Sara. "Microfluidic Mixing System for the Production of Tunable Nanoparticles". Trabalho apresentado em Second Achilles Conference, 2019.
  8. Gimondi, Sara. "Tunable System for Nanoparticles Production Exploiting Microfluidic Mixing". Trabalho apresentado em 1st Discoveries Forum on Regenerative and Precision Medicine, 2019.
  9. Gimondi, Sara. "Exploiting Microfluidic Mixing to Produce Highly-Tunable Polymeric Nanoparticles". Trabalho apresentado em FoReCaST 2nd Workshop, 2019.
  10. Gimondi, Sara. "Exploiting Microfluidic Mixing to Produce Highly-Tunable Polymeric Nanoparticles". Trabalho apresentado em First Achilles Conference, 2019.
Atividades

Arbitragem científica em conferência

Nome da conferência Local da conferência
2023/09/20 - 2023/09/22 HEALTH-UNORTE Final Conference
2022/05/25 - 2022/05/27 Final Achilles Conference
2022/05/24 - 2022/05/25 TERM STEM 2022
2022/05/23 - 2022/05/24 Workshop MicSeaOnMed
2021/10/27 - 2021/10/29 Third Achilles Workshop
2021/10/25 - 2021/10/27 Final FoReCaST Conference
2021/06/15 - 2021/06/18 TERM STEM 2021
2021/06/14 - 2021/06/15 Third Forecast Workshop
2019/11/06 - 2019/11/08 TERM STEM 2019
2019/11/04 - 2019/11/08 20th Anniversary of the 3B’s Research Group.
2019/09/25 - 2019/09/27 1st Discoveries Forum on Regenerative and Precision Medicine
2019/07/11 - 2019/07/12 FoReCaST 2nd Workshop
2019/07/08 - 2019/07/11 1st Achilles Conference
2019/05/08 - 2019/05/08 Workshop “Translational science in musculoskeletal disorders”
2018/12/25 - 2018/12/26 Chem2Nature Workshop
2018/10/23 - 2018/10/24 Gene2Skin and Chem2Nature Final Conferences

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2020/01/27 - 2020/02/07 Laboratory Animal Science Training Course