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During her PhD (2022, MCBiology PhD Program, University of Porto) Joana Nogueira-Rodrigues established the conditions to perform severe spinal cord injury in a new mammalian model- Acomys, and to study regeneration in this species from the functional and molecular standpoints. Joana’s findings were recently published in Developmental Cell (1st author; Dev Cell. 2022; doi: 10.1016/j.devcel.2021.12.008), where she showed for the first time that a mammal can regenerate after CNS injury, overturning a dogma in the field. Joana’s results were selected for presentation in prestigious meetings including Wings for Life (2021), Gordon Research Conference on CNS Injury and Repair (2019) and Wings for Life Summer School (2018). Since 2017, Joana has been lecturing on the subject of spinal cord injury in PhD Programs including the Graduate Program in Basic and Applied Biology (GABBA) and the MSc/PhD Program in Neuroscience - Faculty of Medicine, Univ Porto. Additionally, while doing her PhD, Joana supervised two MSc students. Throughout her training, Joana has been involved in the organization of institutional meetings, such as the annual Symposium of the PhD Program in Molecular and Cellular Biology – Univ Porto (2018) and the 3rd i3S PhD Day (2020). At the international level, she was a staff member (volunteer) at the European Meeting on Glial Cells in Health and Disease. (2019, Porto), and the responsible for neuronal cell culture in the FENS CAJAL Advanced Neuroscience Training Program on Neuronal Cell Biology (2016, Bordeaux). Beyond her expertise in CNS regeneration, during her MSc (Cellular and Molecular Biology, University of Aveiro Aveiro) Joana developed important skills in neuronal cell biology. Her work was focused in understanding the role of two actin-binding proteins (adducin and profilin) in regulating axonal cytoskeleton dynamics. In this respect she contributed to two publications (co-author: Journal of Clinical Investigation 2020 - doi: 10.1172/JCI125771; Cell Reports 2016 - doi: 10.1016/j.celrep.2016.03.047). Her interest in axon regeneration started during her MSc, while collaborating in a project in this field (2nd author, Cerebral Cortex 2017; doi: 10.1093/cercor/bhx023). Joana now wants to deepen her PhD discoveries and move her career forward as a junior postdoctoral fellow at the Nerve Regeneration group- i3S, based on her unique combined expertise in Acomys biology, basic neurobiology and CNS regeneration.
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Identificação

Identificação pessoal

Nome completo
Joana Nogueira Rodrigues

Nomes de citação

  • Nogueira-Rodrigues, Joana

Identificadores de autor

Ciência ID
FD19-6BD5-B69D
ORCID iD
0000-0001-8918-7753

Endereços de correio eletrónico

  • joanrodrigues@live.com.pt (Profissional)
  • Joanrodrigues@live.com.pt (Pessoal)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Português (Idioma materno)
Formação
Grau Classificação
2017/10 - 2022/04
Concluído
 Cellular and Molecular Biology (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
"Identifying molecules and mechanisms enhancing axon growth: Acomys cahirinus as a model of mammalian regeneration" (TESE/DISSERTAÇÃO)
2015
Concluído
 Cellular and Molecular Biology (Mestrado)
Universidade de Aveiro, Portugal
"Dissecting the role of adducin in the axonal cytoskeleton" (TESE/DISSERTAÇÃO)
 17
2014 - 2014
Concluído
 Felasa (category B) Laboratory Animal Science course (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Direcção-Geral de Alimentação e Veterinária, Portugal
2013
Concluído
 Microbiology (Licenciatura)
Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
"Development of inoculation conditions using a viral vector for expression of recombinant proteins in Nicotiana tabacum" (TESE/DISSERTAÇÃO)
 14
2010
Concluído
 Biotecnology (Ensino secundário)
Colégio Internato dos Carvalhos, Portugal
 17
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/05 - Atual Pós-doutorado (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/08/01 - 2017/09/30 Investigador Contratado (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/07/01 - 2016/07/31 Investigador (Investigação) Bordeaux School of Neuroscience, University of Bordeaux, França
Bordeaux School of Neuroscience, University of Bordeaux, França
2015/06/01 - 2016/06/30 Investigador Contratado (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014/09/01 - 2015/07/31 Estagiário de Investigação (Investigação) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
(...)
Projetos

Bolsa

Designação Financiadores
2020/09/30 - 2023/09 SPINY: Characterizing Functional Recovery and Axon Regeneration of the Injured Acomys Spinal Cord
MC-39-2019
Investigador
Instituto de Biologia Molecular e Celular, Portugal
 Santa Casa da Misericórdia de Lisboa

Wings for Life Spinal Cord Research Foundation
Em curso
2020/05 - 2023/05/31 NG4Leuko-Exploring neuron-glia interactions in leukodystrophies using human iPSC-based models: implication for therapy
EJPRD/0002/2020
Investigador
Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
2016/12 - 2018/12/31 PARES- Pairing rehabilitation and Axonal REgenerative therapies towards promoting Spinal cord repair
N/A
Investigador
Santa Casa da Misericórdia de Lisboa, Portugal
 Santa Casa da Misericórdia de Lisboa
Concluído
2017/04 - 2018/04/01 ProREGEN- Constitutively Active Profilin1: The key to Axon Growth and Regeneration
N/A
Investigador
Instituto de Biologia Molecular e Celular, Portugal
 Comissao de Coordenacao e Desenvolvimento Regional do Norte
Concluído
2014/04 - 2016/04 Testing HDAC inhibitors as a therapeutic option to prevent early axonal loss in leukodystrophies
N/A
Bolseiro de Investigação
Instituto de Biologia Molecular e Celular, Portugal
Concluído

Outro

Designação Financiadores
2014/09 - 2015/07 Modulating Actin Dynamics during axonal regeneration: the role of adducin and profilin-1.
P140
Investigador
Concluído
Produções

Publicações

Artigo em revista
  1. Vitorino, Marta; Simão, Sónia; Moreira, João B.; Nogueira-Rodrigues, Joana; Silva, Joana; Lourenço, Ana Sofia; Fernandes, Vítor; et al. "Coronal brain atlas in stereotaxic coordinates of the African spiny mouse, Acomys cahirinus". Journal of Comparative Neurology (2022): http://dx.doi.org/10.1002/cne.25329.
    Publicado • 10.1002/cne.25329
  2. Nogueira-Rodrigues, Joana; Leite, Sérgio C.; Pinto-Costa, Rita; Sousa, Sara C.; Luz, Liliana L.; Sintra, Maria A.; Oliveira, Raquel; et al. "Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection". Developmental Cell (2022): http://dx.doi.org/10.1016/j.devcel.2021.12.008.
    Publicado • 10.1016/j.devcel.2021.12.008
  3. Pinto-Costa, Rita; Castro Sousa, Sara; Leite, Sérgio C.; Nogueira-Rodrigues, Joana; Ferreira da Silva, Tiago; Machado, Diana; Marques, Joana Beatriz Moreira; et al. "Profilin1 delivery tunes cytoskeleton dynamics towards CNS axon regeneration". Journal of Clinical Investigation (2020): http://dx.doi.org/10.1172/jci125771.
    10.1172/jci125771
  4. Franquinho, Filipa; Nogueira-Rodrigues, Joana; Duarte, Joana M.; Esteves, Sofia S.; Carter-Su, Christin; Monaco, Anthony P.; Molnár, Zoltán; et al. "The Dyslexia-susceptibility Protein KIAA0319 Inhibits Axon Growth Through Smad2 Signaling". Cerebral Cortex 27 3 (2017): 1732-1747. http://dx.doi.org/10.1093/cercor/bhx023.
    10.1093/cercor/bhx023
  5. Nogueira-Rodrigues, Joana; Brites, Pedro; Sousa, Mónica Mendes. "Axonal pathology in Krabbe's disease: The cytoskeleton as an emerging therapeutic target". Journal of Neuroscience Research 94 11 (2016): 1037-1041. http://dx.doi.org/10.1002/jnr.23771.
    10.1002/jnr.23771
  6. Leite, Sérgio Carvalho; Sampaio, Paula; Sousa, Vera Filipe; Nogueira-Rodrigues, Joana; Pinto-Costa, Rita; Peters, Luanne Laurel; Brites, Pedro; Sousa, Mónica Mendes. "The Actin-Binding Protein a-Adducin Is Required for Maintaining Axon Diameter". Cell Reports 15 3 (2016): 490-498. http://dx.doi.org/10.1016/j.celrep.2016.03.047.
    10.1016/j.celrep.2016.03.047
Tese / Dissertação
  1. "Identifying molecules and mechanisms enhancing axon growth: Acomys cahirinus as a model of mammalian regeneration". Doutoramento, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2022.
  2. Rodrigues, Joana Nogueira. "Dissecting the role of adducin in the axonal cytoskeleton". Mestrado, 2015. http://hdl.handle.net/10773/14771.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2022/06/13 Translating Acomys to Mus: identifying the roadmap that enables axon regeneration in mammals 2nd International meeting of Portuguese spinal cord injury researchers
FMUP (Porto, Portugal)
2021/04/14 SPINY: Identifying and Modulating the Mechanisms Responsible for Functional Recovery and Axon Regeneration of the Injured Acomys Spinal Cord Wings for Life - scientific meeting
Wings for Life (Virtual meeting)
2018/11/29 The African Spiny Mouse regenerates after complete spinal cord injury. I3S ANNUAL MEETING
I3S (Póvoa do Varzim, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2021/09 - 2022 MSc thesis: Dissecting the role of B3gnt7 as an enhancer of axon regeneration
Coorientador
 Neuroscience (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
2017 - 2018 MSc thesis: New molecules and mechanisms enhancing axon growth after spinal cord injury (Co-supervisor)
Coorientador
 Bioengenharia (Mestrado)
Universidade do Porto Faculdade de Engenharia, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2019/07/10 - 2019/07/13 Staff Volunteer, European Meeting on Glial Cells in Health and Disease. (2019/07/10 - 2019/07/13)
Congresso

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2022/09 - 2022/09 Pitch and poster presentation at EMBO workshop - "Translating Acomys to Mus: identifying the roadmap that enables axon regeneration in mammals"
Oficina (workshop)
 The molecular and cellular basis of regeneration and tissue repair
2019/11/28 - 2019/11/29 Poster presentation at I3S Annual Meeting (poster 1st author). Poster entitled "Acomys, the African Spiny Mouse, displays axon regeneration and gain of motor and bladder function after complete spinal cord injury".
Encontro
 I3S ANNUAL MEETING
2019/06/16 - 2019/06/21 Poster presentation at GRC on Central Nervous System Injury and Repair: Spinal Cord Injury and Repair: From Molecules to Function, Waterville Valley, New Hampshire, United States (poster 1st author). Poster entitled "Acomys, the African Spiny Mouse, displays axon regeneration and gain of motor and bladder function after complete spinal cord injury".
Conferência
 Gordon Research Conference on Central Nervous System Injury and Repair: Spinal Cord Injury and Repair: From Molecules to Function
2018/07/01 - 2018/07/06 Poster presentation at Wings for Life Neurotrauma and Spinal Cord Injury Summer School, Glasgow, Scotland (poster 1st author). Poster entitled "The African Spiny Mouse regenerates after complete spinal cord injury".
Congresso
 Neurotrauma and Spinal Cord Injury Summer School
2016/11/03 - 2016/11/04 Poster presentation at i3S Fifth Annual Meeting, Povoa de Varzim, Portugal. Poster entitled "The dyslexia-susceptibility protein KIAA0319 inhibits axon growth through Smad2 signaling".
Encontro
 I3S ANNUAL MEETING

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2018 - Atual Lecturer on module of Nerve Regeneration- Neuroscience PhD/MSc Program (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2018/05/28 - 2018/06/01 In vitro cultures of neurons and glia and animal models of nerve and spinal cord injury and neurolipids in axon growth, myelination, degeneration and regeneration Graduate Program in Areas of Basic and Applied Biology (GABBA) (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/05/15 - 2017/05/19 In vitro cultures of neurons and glia and animal models of nerve and spinal cord injury Graduate Program in Areas of Basic and Applied Biology (GABBA) (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016/07/01 - 2016/07/31 Cell culture monitor in the FENS Cajal 2016 summer course on Neuronal Cell Biology: Cytoskeleton and Trafficking, The CAJAL Advanced Neuroscience Training Programme. Bordeaux School of Neuroscience, University of Bordeaux, França

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2020/01/01 - 2020/10/01 Member of the Organizing Committee of 3rd PhDay | Back to the Future - i3S
Membro
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/11/22 - 2018/11/22 Member of the Organizing Committee of Symposium - The Secret Life of the Cell - PhD Program MCBiology Symposium
Membro
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Distinções

Prémio

2020 Wings for Life Spinal Cord Research Foundation. SPINY: Identifying and Modulating the Mechanisms Responsible for Functional Recovery and Axon Regeneration of the Injured Acomys Spinal Cord
Wings for Life Spinal Cord Research Foundation, Reino Unido
2019 Prémio Melo e Castro - SPINY: Characterizing Functional Recovery and Axon Regeneration of the Injured Acomys Spinal Cord
Santa Casa da Misericórdia de Lisboa, Portugal
2016 Prémio Melo e Castro - COMBINE Combinatorial regenerative strategy to potentiate axon regeneration and improve functional recovery after spinal cord injury.
Santa Casa da Misericórdia de Lisboa, Portugal