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Rui Moreira is a medicinal chemist by training, with a Master in Pharmaceutical Sciences and Industrial Pharmacy (1986) and a PhD degree in Pharmacy/Medicinal Chemistry (1991) from the University of Lisbon. After completing the compulsory military service in 1992, he visited the Department of Chemistry at The Open University UK, as a postdoctoral researcher. He joined the Faculty of Pharmacy at the University of Lisbon (FFUL) in 1992 as an assistant professor and went up the ranks to be a Full Professor in 2006. From 2010 to 2013, Rui Moreira was the coordinator of the Research Institute for Medicines (iMed.ULisboa), and since 2022 he is the president of the Department of Pharmaceutical Sciences and Medicines at FFUL, overseeing the activities of ca. 100 professors, lecturers, researchers, and technicians. He is a co-founder and board member of PT-OPENSCREEN, a national infrastructure for chemical biology and genetics, which recently joined the ERIC EU-OPENSCREEN (EU-OS). Rui Moreira is the leader of iMed.ULisboa’s Medicinal Chemistry Partner Site at EU-OS since 2022. He was the President the European Federation for Medicinal Chemistry and Chemical Biology (EFMC) from 2021 to 2023, being currently its Past President. Rui Moreira leads the medicinal chemistry research group at iMed.ULisboa, which comprises 3 associate researchers, 2 postdocs, and 10 PhD students, and 4 MSc students. He published 180 papers, including in high impact journals such as J Amer Chem Soc, Angew Chem, Proc Natl Acad Sci and J Med Chem, and has delivered more than 60 talks. He successfully (co)supervised >50 PhD/MSc students and postdocs and has been funded through competitive projects and grants from national and EU programs.
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Identificação

Identificação pessoal

Nome completo
Rui Moreira

Nomes de citação

  • Moreira, Rui

Identificadores de autor

Ciência ID
8B11-E8C0-DFD0
ORCID iD
0000-0003-0727-9852
Researcher Id
G-7485-2011
Scopus Author Id
7102554088

Endereços de correio eletrónico

  • rmoreira@ff.ul.pt (Profissional)

Moradas

  • Faculty of Pharmacy, University of Lisbon, Av. Professor Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Profissional)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Medicina Básica - Química Médica
  • Ciências Exatas - Química - Química Orgânica
  • Ciências Médicas e da Saúde - Ciências da Saúde - Doenças Infeciosas
  • Ciências Médicas e da Saúde - Medicina Básica - Farmacologia e Farmácia
  • Ciências Naturais - Ciências Biológicas - Bioquímica

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Francês Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1) Utilizador independente (B1)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2004
Concluído
 Pharmaceutical Sciences (Título de Agregado)
Especialização em Medicinal Chemistry
Universidade de Lisboa Faculdade de Farmácia, Portugal
1991/06
Concluído
 Farmácia (Doutoramento)
Especialização em Pharmaceutical and Medicinal Chemistry
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Contribution to the development of prodrugs for several anticancer agents" (TESE/DISSERTAÇÃO)
1980 - 1985/07
Concluído
 Ciências Farmacêuticas (Licenciatura)
Especialização em Industrial Pharmacy
Universidade de Lisboa Faculdade de Farmácia, Portugal
 18/20
Percurso profissional

Docência no Ensino Superior

Categoria Profissional
Instituição de acolhimento 		Empregador
2006/10/01 - Atual Professor Catedrático (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
(...)
2002/10/01 - 2006/10/31 Professor Associado (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
1991/10/01 - 2002/09/30 Professor Auxiliar (Docente Universitário) Universidade de Lisboa Faculdade de Farmácia, Portugal
Projetos

Bolsa

Designação Financiadores
2018/10/01 - 2021/09/30 Tricks or Treats? Toward Selective Organoruthenium(II) Glycoconjugated Anticancer Agents RuGly
PTDC/MED-QUI/31468/2017
Investigador
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Universidade Nova de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/10 - 2021/09 NPSTEENSBRAIN. New Psychoactive Substances - A Platform for Risk Assessment of Teens Brain Exposure
PTDC/SAU-TOX/32515/2017
Investigador
Fundação para a Ciência e a Tecnologia
Em curso
2014/01 - 2015/12 Incentive - UI 4013 - 2014
Provided by PTCRIS: 137395
Investigador responsável
Fundação para a Ciência e a Tecnologia

Projeto

Designação Financiadores
2024/02/01 - 2027/01/31 IMPULSE. IMProving User experience, Long-term sustainability and Services of EU-OPENSCREEN
DLV-101132028
Investigador
Universidade de Lisboa Faculdade de Farmácia, Portugal
Em curso
2023/03/01 - 2026/02/28 FRAGMENT-SCREEN
101094131
Investigador
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Horizon 2020
Em curso
2022 - 2026 OncoProTools
101073231
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
 EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
Em curso
2023/01/01 - 2025/12 Ferrous Iron-Activable Drug Conjugates: Targeting Iron Metabolism in the Era of Precision Oncology
2022.07857.PTDC
Investigador responsável
Associação da Faculdade de Farmácia para a Investigação e Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia
2022/06 - 2024/06 Iron-triggered technologies as a novel targeted therapy for cancer
LCF/TR/CI22/52660003
Co-Investigador Responsável (Co-IR)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação 'la Caixa'
2018/10/01 - 2021/09/30 A multitarget strategy to hit all stages of the Plasmodium life-cycle
PTDC/MED-QUI/30021/2017
Investigador responsável
Universidade Nova de Lisboa, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal

Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/08/10 - 2021/08/09 Dialysis membranes by design: targeting neutrophil elastase to reduce inflammation/oxidative stress in end-stage renal disease
PTDC/MEC-CAR/31322/2017
PTDC/MED-CAR/31322/2017
POCI-01-0145-FEDER-031322
POCI-01-0145-FEDER-031322
Investigador
Universidade de Coimbra, Portugal

Universidade do Porto, Portugal

Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/06/01 - 2021/05/31 Fígado Gordo Não-alcoólico: Biomarcardores, Alvos e Terapias Emergentes
PTDC/MED-FAR/29097/2017
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2018/06/01 - 2021/05/31 Target@TB. Exploring a novel chemical tool to unveil new therapies and molecular targets for tuberculosis
PTDC/MED-FAR/30266/2017
Investigador
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2017/01/01 - 2020/12/31 PRECISION ONCOLOGY BY INNOVATIVE THERAPIES AND TECHNOLOGIES
SAICTPAC/0019/2015
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Instituto Politécnico de Leiria, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2016/07/01 - 2020/06/30 Small-molecule inhibitors of human proteasome: a step forward in anticancer drug discovery
PTDC/QEQ-MED/7042/2014
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Universidade da Beira Interior, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2016/06/01 - 2019/12/31 Exploring TOR/PI3K kinases as targets for treating protozoan neglected tropical diseases
PTDC/QEQ-MED/7097/2014
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/06/01 - 2019/12/31 ProbeCOPD. Protease activity-based probes for Chronic Obstructive Pulmonary Disease diagnostics
PTDC/BBB-BEP/2463/2014
Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2016/07/01 - 2019/06/30 New Drugs to Treat Non-alcoholic Fatty Liver and Progression to Cancer
PTDC/BIM-MEC/0895/2014
Centro Hospitalar de Lisboa Central EPE, Portugal

Centro Hospitalar Universitário Lisboa Norte EPE, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2014/04/15 - 2015/10/14 BioClick@LSMal. Bioorthogonal clickable probes to target the liver stage of malaria
EXPL/QEQ-MED/1574/2013
Investigador
Fundação para a Ciência e a Tecnologia
Concluído
2012/03/01 - 2015/08/31 Towards malaria eradication. A novel approach for multi-targeting the parasite´s life cycle
PTDC/SAU-FAR/118459/2010
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2013/06/24 - 2014/12/25 Exploring a new approach to target KRAS oncogene
EXPL/QEQ-MED/0502/2012
 Fundação para a Ciência e a Tecnologia
Concluído
2011/03/01 - 2014/08/31 TARGETING HEMOZOIN CRYSTAL STRUCTURE: A RATIONAL APPROACH TO THE DESIGN OF NOVEL ANTIMALARIALS
PTDC/SAU-FAR/114864/2009
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2011/01/01 - 2013/12/31 Strategic Project - UI 4013 - 2011-2012
PEst-OE/SAU/UI4013/2011
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2010/04/01 - 2013/09/30 New drugs for treating and eradicating malaria
HMSP-CT/SAU-ICT/0068/2009
Instituto de Medicina Molecular João Lobo Antunes, Portugal

Fundação Calouste Gulbenkian, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2010/01/01 - 2013/06/30 Targeting the mitochondrial electron transport chain of malaria parasites: computer-assisted design and synthesis of bc1 complex inhibitors as antimalarial agents
PTDC/SAU-FCF/098734/2008
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluído
2009/07/01 - 2011/12/31 Advancing the field of drug delivery - combined targeted treatments against human breast cancer and human leukemia (The OncotargetNanoMed network)
NANO/NMed-AT/0042/2007
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Aveiro, Portugal

Universidade do Minho, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2008/01/01 - 2011/12/30 Rhodium catalysed C-H bond activation and C-C bond formation in water and bio-compatible solvents - An expeditious way to prepare biologically active heterocycles
PTDC/QUI/66695/2006
Universidade de Lisboa Centro de Química-Física Molecular, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2007/11/02 - 2011/10/31 Chemical reactivity as a tool in drug design: modification of the beta-lactam scaffold to improve serine protease inhibition
PTDC/QUI/64056/2006
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
2005/08/01 - 2007/09/30 Biochemical characterization and inhibition studies of recombinant cysteine proteases of Plasmodium chabaudi, an animal model for human malaria.
POCI/SAU-ESP/57696/2004
Universidade Nova de Lisboa Instituto de Higiene e Medicina Tropical, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluído
Produções

Publicações

Artigo em conferência
  1. Inês Moranguinho; Pedro Borrego; João Lavrado; Rui Moreira; Nuno Taveira. "New Compound Combining an Integrase-Targeting Aptamer and a Small Interfering RNA Targeting the Trans-Activation Response/Poly A Region of HIV-1 Potently Suppresses HIV-1 Replication". 2023.
    10.3390/msf2023022023
  2. Rocha, Susana; Morgo¿ová, Kristína; Valente, Maria João; Amorim, Célia; Araújo, Alberto; Santos-Silva, Alice; Moreira, Rui; Branco da Silva Montenegro, Maria Conceição. "DOPING POLYSULFONE DIALYSIS MEMBRANES WITH HUMAN NEUTROPHIL ELASTASE INHIBITORS - A PILOT STUDY". Trabalho apresentado em Nephrology Dialysis Transplantation, 2021.
    10.1093/ndt/gfab113.002
Artigo em revista
  1. Joana Gonçalves; Joana D. Amaral; Rita Capela; Maria de Jesus Perry; Cláudia Braga; Maria Manuela Gaspar; Fátima M. Piedade; et al. "Necroptosis induced by ruthenium (II) complexes as mitochondrial disruptors". Cell Death Discovery (2024): http://dx.doi.org/10.1038/s41420-024-02033-z.
    10.1038/s41420-024-02033-z
  2. Leite, Debora I.; Campaniço, Andre; Costa, Pedro A. G.; Correa, Isadora A.; da Costa, Luciana J.; Bastos, Monica M.; Moreira, Rui; et al. "New azaaurone derivatives as potential multitarget agents in HIV-TB coinfection". Archiv der Pharmazie 357 2 (2023): http://dx.doi.org/10.1002/ardp.202300560.
    10.1002/ardp.202300560
  3. Campaniço, André; Harjivan, Shrika G.; Freitas, Elisabete; Serafini, Marco; Gaspar, M. Manuela; Capela, Rita; Gomes, Pedro; et al. "Structural Optimization of Antimycobacterial Azaaurones Towards Improved Solubility and Metabolic Stability". ChemMedChem 18 24 (2023): http://dx.doi.org/10.1002/cmdc.202300410.
    10.1002/cmdc.202300410
  4. Yang, Jian; Carvalho, Luís A. R.; Ji, Shanping; Chen, Suyuan; Moreira, Rui; Verhelst, Steven H. L.. "4-Oxo-ß-Lactams as Novel Inhibitors for Rhomboid Proteases". ChemBioChem 24 21 (2023): http://dx.doi.org/10.1002/cbic.202300418.
    10.1002/cbic.202300418
  5. da Silva, Gustavo; André F. S. Luz; Duarte, Denise; Fontinha, Diana; Silva, Vera L. M.; Almeida Paz, Filipe A.; Madureira, Ana M.; et al. Autor correspondente: da Silva, Gustavo. "Facile access to structurally diverse antimalarial indoles using a one-pot A3 coupling and domino cyclization approach". ChemMedChem (2023): http://dx.doi.org/10.1002/cmdc.202300264.
    10.1002/cmdc.202300264
  6. Debora Inacio Leite; Stefany de Castro Bazan Moura; Maria da Conceição Avelino Dias; Carolina Catta Preta Costa; Gustavo Peixoto Machado; Luiz Claudio Ferreira Pimentel; Frederico Silva Castelo Branco; et al. "A Review of the Development of Multitarget Molecules against HIV-TB Coinfection Pathogens". Molecules (2023): https://doi.org/10.3390/molecules28083342.
    10.3390/molecules28083342
  7. Susana Rocha; Rita Félix; Maria Valente; Andreia Bento-Silva; Rute Rebelo; Célia Amorim; Alberto Araújo; et al. "Polysulfone Membranes Doped with Human Neutrophil Elastase Inhibitors: Assessment of Bioactivity and Biocompatibility". Membranes (2023): https://doi.org/10.3390/membranes13010089.
    10.3390/membranes13010089
  8. Chiara Borsari; Brieuc Matagne; Kristina Goncharenko; Rui Moreira; Yves P. Auberson. "The Facets of Diversity: The EFMC Perspective**". ChemMedChem (2023): https://doi.org/10.1002/cmdc.202200245.
    10.1002/cmdc.202200245
  9. Yang, J.; Carvalho, L.A.R.; Ji, S.; Chen, S.; Moreira, R.; Verhelst, S.H.L.. "4-Oxo-ß-Lactams as Novel Inhibitors for Rhomboid Proteases". ChemBioChem 24 21 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85171262930&partnerID=MN8TOARS.
    10.1002/cbic.202300418
  10. Carvalho, Luís A. R.; Ross, Breyan; Fehr, Lorenz; Bolgi, Oguz; Wöhrle, Svenja; Lum, Kenneth M.; Podlesainski, David; et al. "Chemoproteomics-Enabled Identification of 4-Oxo-ß-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9". Angewandte Chemie International Edition 61 47 (2022): http://dx.doi.org/10.1002/anie.202210498.
    Publicado • 10.1002/anie.202210498
  11. Carvalho, Luís A. R.; Ross, Breyan; Fehr, Lorenz; Bolgi, Oguz; Wöhrle, Svenja; Lum, Kenneth M.; Podlesainski, David; et al. "Chemoproteomik-basierte Identifikation von 4-Oxo-ß-lactamen als Inhibitoren der Dipeptidylpeptidasen 8¿und 9". Angewandte Chemie 134 47 (2022): http://dx.doi.org/10.1002/ange.202210498.
    Publicado • 10.1002/ange.202210498
  12. Natália Aniceto; Vanda Marques; Joana D. Amaral; Patrícia A. Serra; Rui Moreira; Cecília M. P. Rodrigues; Rita C. Guedes. "Harnessing Protein-Ligand Interaction Fingerprints to Predict New Scaffolds of RIPK1 Inhibitors". Molecules (2022): https://doi.org/10.3390/molecules27154718.
    10.3390/molecules27154718
  13. Rafael F. A. Gomes; Joao M. J. M. Ravasco; Késsia H. S. Andrade; Jaime A. S. Coelho; Rui Moreira; Rafael Oliveira; Fátima Nogueira; Carlos A. M. Afonso. "Tandem Thio-Michael Addition/Remote Lactone Activation of 5-Hydroxymethylfurfural-Derived d-Lactone-Fused Cyclopentenones". ChemSusChem (2022): https://doi.org/10.1002/cssc.202102204.
    10.1002/cssc.202102204
  14. Solida Long; Denise Duarte; Carla Carvalho; Rafael Oliveira; Nuno Santarém; Andreia Palmeira; Diana I. S. P. Resende; et al. "Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones Active against Plasmodium and Trypanosomatids". ACS Medicinal Chemistry Letters (2022): https://doi.org/10.1021/acsmedchemlett.1c00589.
    10.1021/acsmedchemlett.1c00589
  15. Liu, X.; Kalogeropulou, A.F.; Domingos, S.; Makukhin, N.; Nirujogi, R.S.; Singh, F.; Shpiro, N.; et al. "Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2". Journal of the American Chemical Society 144 37 (2022): 16930-16952. http://www.scopus.com/inward/record.url?eid=2-s2.0-85137398154&partnerID=MN8TOARS.
    10.1021/jacs.2c05499
  16. Sara R. Oliveira; Pedro A. Dionísio; Maria M. Gaspar; Maria B. T. Ferreira; Catarina A. B. Rodrigues; Rita G. Pereira; Mónica S. Estevão; et al. "Discovery of a Necroptosis Inhibitor Improving Dopaminergic Neuronal Loss after MPTP Exposure in Mice". International Journal of Molecular Sciences 22 10 (2021): 5289-5289. https://doi.org/10.3390/ijms22105289.
    10.3390/ijms22105289
  17. Almeida, A.F.; Ataíde, F.A.P.; Loureiro, R.M.S.; Moreira, R.; Rodrigues, T.. "Augmenting Adaptive Machine Learning with Kinetic Modeling for Reaction Optimization". Journal of Organic Chemistry 86 20 (2021): 14192-14198. http://www.scopus.com/inward/record.url?eid=2-s2.0-85110973936&partnerID=MN8TOARS.
    10.1021/acs.joc.1c01038
  18. Miethke, M.; Pieroni, M.; Weber, T.; Brönstrup, M.; Hammann, P.; Halby, L.; Arimondo, P.B.; et al. "Towards the sustainable discovery and development of new antibiotics". Nature Reviews Chemistry 5 10 (2021): 726-749. http://www.scopus.com/inward/record.url?eid=2-s2.0-85110714419&partnerID=MN8TOARS.
    10.1038/s41570-021-00313-1
  19. Barbosa, M.; Gomes, C.; Sequeira, C.; Gonçalves-Ribeiro, J.; Pina, C.C.; Carvalho, L.A.; Moreira, R.; et al. "Recovery of Depleted miR-146a in ALS Cortical Astrocytes Reverts Cell Aberrancies and Prevents Paracrine Pathogenicity on Microglia and Motor Neurons". Frontiers in Cell and Developmental Biology 9 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85105432735&partnerID=MN8TOARS.
    10.3389/fcell.2021.634355
  20. Gomes-Alves, A.G.; Duarte, M.; Cruz, T.; Castro, H.; Lopes, F.; Moreira, R.; Ressurreição, A.S.; Tomás, A.M.. "Biological evaluation and mechanistic studies of quinolin-(1H)-imines as a new chemotype against leishmaniasis". Antimicrobial Agents and Chemotherapy 65 7 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85108296688&partnerID=MN8TOARS.
    10.1128/AAC.01513-20
  21. André Campaniço; Shrika G. Harjivan; Digby F. Warner; Rui Moreira; Francisca Lopes. "Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds". International Journal of Molecular Sciences 21 22 (2020): 8854-8854. https://doi.org/10.3390/ijms21228854.
    10.3390/ijms21228854
  22. Brito, H.; Marques, V.; Afonso, M.B.; Brown, D.G.; Börjesson, U.; Selmi, N.; Smith, D.M.; et al. "Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition". Cell Death Discovery 6 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85079729058&partnerID=MN8TOARS.
    10.1038/s41420-020-0240-0
  23. de Mello-Sampayo, C.; Vaz, A.R.; Henriques, S.C.; Fernandes, A.; Paradinha, F.; Florindo, P.; Faria, P.; et al. "Designer Cathinones N-Ethylhexedrone and Buphedrone Show Different In Vitro Neurotoxicity and Mice Behaviour Impairment". Neurotoxicity Research (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85086428280&partnerID=MN8TOARS.
    10.1007/s12640-020-00229-6
  24. Carvalho, L.A.R.; Almeida, V.T.; Brito, J.A.; Lum, K.M.; Oliveira, T.F.; Guedes, R.C.; Gonçalves, L.M.; et al. "3-Oxo-ß-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling". ACS Chemical Biology 15 4 (2020): 878-883. http://www.scopus.com/inward/record.url?eid=2-s2.0-85083620100&partnerID=MN8TOARS.
    10.1021/acschembio.0c00090
  25. Milheiro, S.A.; Gonçalves, J.; Lopes, R.M.R.M.; Madureira, M.; Lobo, L.; Lopes, A.; Nogueira, F.; et al. "Half-Sandwich Cyclopentadienylruthenium(II) Complexes: A New Antimalarial Chemotype". Inorganic Chemistry 59 17 (2020): 12722-12732. http://www.scopus.com/inward/record.url?eid=2-s2.0-85090481236&partnerID=MN8TOARS.
    10.1021/acs.inorgchem.0c01795
  26. Carrola, J.; Duarte, N.; Florindo, P.; Henriques, S.; da Silva, G.; Bijlsma, L.; Moreira, R.; et al. "Metabolism of N-ethylhexedrone and buphedrone: An in vivo study in mice using HPLC-MS/MS". Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 1159 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85090272900&partnerID=MN8TOARS.
    10.1016/j.jchromb.2020.122340
  27. Oliveira, G.N.P.; Teixeira, R.C.; Moreira, R.P.; Correia, J.G.; Araújo, J.P.; Lopes, A.M.L.. "Local inhomogeneous state in multiferroic SmCrO3". Scientific Reports 10 1 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85081983670&partnerID=MN8TOARS.
    10.1038/s41598-020-61384-6
  28. Cláudia Braga; Ana R. Vaz; M. Conceição Oliveira; M. Matilde Marques; Rui Moreira; Dora Brites; Maria J. Perry. "Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability". European Journal of Medicinal Chemistry 172 (2019): 16-25. https://doi.org/10.1016/j.ejmech.2019.03.048.
    10.1016/j.ejmech.2019.03.048
  29. de Almeida, A.F.; Moreira, R.; Rodrigues, T.. "Synthetic organic chemistry driven by artificial intelligence". Nature Reviews Chemistry 3 10 (2019): 589-604. http://www.scopus.com/inward/record.url?eid=2-s2.0-85071226878&partnerID=MN8TOARS.
    10.1038/s41570-019-0124-0
  30. Capela, R.; Moreira, R.; Lopes, F.. "An overview of drug resistance in protozoal diseases". International Journal of Molecular Sciences 20 22 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85075088498&partnerID=MN8TOARS.
    10.3390/ijms20225748
  31. Campaniço, A.; Carrasco, M.P.; Njoroge, M.; Seldon, R.; Chibale, K.; Perdigão, J.; Portugal, I.; et al. "Azaaurones as Potent Antimycobacterial Agents Active against MDR- and XDR-TB". ChemMedChem 14 16 (2019): 1537-1546. http://www.scopus.com/inward/record.url?eid=2-s2.0-85069925921&partnerID=MN8TOARS.
    10.1002/cmdc.201900289
  32. Vaz, A.R.; Pinto, S.; Ezequiel, C.; Cunha, C.; Carvalho, L.A.; Moreira, R.; Brites, D.. "Phenotypic effects of wild-type and mutant SOD1 expression in n9 murine microglia at steady state, inflammatory and immunomodulatory conditions". Frontiers in Cellular Neuroscience 13 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85064224780&partnerID=MN8TOARS.
    10.3389/fncel.2019.00109
  33. Domingos, S.; Duarte, T.; Saraiva, L.; Guedes, R.C.; Moreira, R.. "Targeting leucine-rich repeat kinase 2 (LRRK2) for the treatment of Parkinson's disease". Future Medicinal Chemistry 11 16 (2019): 1953-1977. http://www.scopus.com/inward/record.url?eid=2-s2.0-85072144253&partnerID=MN8TOARS.
    10.4155/fmc-2018-0484
  34. Lopes, A.M.L.; Teixeira, R.C.; Moreira, R.P.; Petrilli, H.M.; Assali, L.V.C.; Araújo, J.P.. "Monitoring LaMnO3Jahn-Teller distortion via electric-field gradient ab initio calculations". Electronic Structure 1 4 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85106921830&partnerID=MN8TOARS.
    10.1088/2516-1075/ab4ed6
  35. João P. M. António; Lídia M. Gonçalves; Rita C. Guedes; Rui Moreira; Pedro M. P. Gois. "Diazaborines as New Inhibitors of Human Neutrophil Elastase". ACS Omega (2018): https://doi.org/10.1021/acsomega.8b00702.
    10.1021/acsomega.8b00702
  36. Duarte, A.R.; Cadoni, E.; Ressurreição, A.S.; Moreira, R.; Paulo, A.. "Design of Modular G-quadruplex Ligands". ChemMedChem 13 9 (2018): 869-893. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045335649&partnerID=MN8TOARS.
    10.1002/cmdc.201700747
  37. Marto, J.; Ruivo, E.; Lucas, S.D.; Gonçalves, L.M.; Simões, S.; Gouveia, L.F.; Felix, R.; et al. "Starch nanocapsules containing a novel neutrophil elastase inhibitor with improved pharmaceutical performance". European Journal of Pharmaceutics and Biopharmaceutics 127 (2018): 1-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-85041571552&partnerID=MN8TOARS.
    10.1016/j.ejpb.2018.01.011
  38. Campaniço, A.; Moreira, R.; Lopes, F.. "Drug discovery in tuberculosis. New drug targets and antimycobacterial agents". European Journal of Medicinal Chemistry 150 (2018): 525-545. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043527030&partnerID=MN8TOARS.
    10.1016/j.ejmech.2018.03.020
  39. Capela, R.; Magalhães, J.; Miranda, D.; Machado, M.; Sanches-Vaz, M.; Albuquerque, I.S.; Sharma, M.; et al. "Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability". European Journal of Medicinal Chemistry 149 (2018): 69-78. http://www.scopus.com/inward/record.url?eid=2-s2.0-85042651839&partnerID=MN8TOARS.
    10.1016/j.ejmech.2018.02.048
  40. Ribeiro, C.J.A.; Nunes, R.C.; Amaral, J.D.; Gonçalves, L.M.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Spirotriazoline oxindoles: A novel chemical scaffold with in vitro anticancer properties". European Journal of Medicinal Chemistry 140 (2017): 494-509. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030537870&partnerID=MN8TOARS.
    10.1016/j.ejmech.2017.09.037
  41. Falcão, A.S.; Carvalho, L.A.R.; Lidónio, G.; Vaz, A.R.; Lucas, S.D.; Moreira, R.; Brites, D.. "Dipeptidyl Vinyl Sulfone as a Novel Chemical Tool to Inhibit HMGB1/NLRP3-Inflammasome and Inflamma-miRs in Aß-Mediated Microglial Inflammation". ACS Chemical Neuroscience 8 1 (2017): 89-99. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013640037&partnerID=MN8TOARS.
    10.1021/acschemneuro.6b00250
  42. Pinheiro, R.; Braga, C.; Santos, G.; Bronze, M.R.; Perry, M.J.; Moreira, R.; Brites, D.; Falcão, A.S.. "Targeting Gliomas: Can a New Alkylating Hybrid Compound Make a Difference?". ACS Chemical Neuroscience 8 1 (2017): 50-59. http://www.scopus.com/inward/record.url?eid=2-s2.0-85013797326&partnerID=MN8TOARS.
    10.1021/acschemneuro.6b00169
  43. Carrasco, M.P.; Machado, M.; Gonçalves, L.; Sharma, M.; Gut, J.; Lukens, A.K.; Wirth, D.F.; et al. "Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites". ChemMedChem (2016): 2194-2204. http://www.scopus.com/inward/record.url?eid=2-s2.0-84989959759&partnerID=MN8TOARS.
    10.1002/cmdc.201600327
  44. Sousa, M.E.; Araújo, M.J.; Do Vale, M.L.; Andrade, P.B.; Branco, P.; Gomes, P.; Moreira, R.; Pinho E Melo, T.M.V.D.; Freitas, V.. "11thnational meeting of organic chemistry and 4th meeting of therapeutic chemistry". Pharmaceuticals 9 1 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84977567343&partnerID=MN8TOARS.
    10.3390/ph9010015
  45. Ribeiro, C.J.A.; Amaral, J.D.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Spirooxadiazoline oxindoles with promising in vitro antitumor activities". MedChemComm 7 3 (2016): 420-425. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961801651&partnerID=MN8TOARS.
    10.1039/c5md00450k
  46. Ribeiro, C.J.A.; Espadinha, M.; Machado, M.; Gut, J.; Gonçalves, L.M.; Rosenthal, P.J.; Prudêncio, M.; Moreira, R.; Santos, M.M.M.. "Novel squaramides with in vitro liver stage antiplasmodial activity". Bioorganic and Medicinal Chemistry 24 8 (2016): 1786-1792. http://www.scopus.com/inward/record.url?eid=2-s2.0-84960971045&partnerID=MN8TOARS.
    10.1016/j.bmc.2016.03.005
  47. Ruivo, E.F.P.; Gonçalves, L.M.; Carvalho, L.A.R.; Guedes, R.C.; Hofbauer, S.; Brito, J.A.; Archer, M.; Moreira, R.; Lucas, S.D.. "Clickable 4-Oxo-ß-lactam-Based Selective Probing for Human Neutrophil Elastase Related Proteomes". ChemMedChem (2016): 2037-2042. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988410118&partnerID=MN8TOARS.
    10.1002/cmdc.201600258
  48. Ribeiro, C.J.A.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Chemical variations on the p53 reactivation theme". Pharmaceuticals 9 2 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84973316044&partnerID=MN8TOARS.
    10.3390/ph9020025
  49. Lavrado, J.; Ohnmacht, S.A.; Correia, I.; Leitão, C.; Pisco, S.; Gunaratnam, M.; Moreira, R.; et al. "Indolo[3,2-c]quinoline G-quadruplex stabilizers: A structural analysis of binding to the human telomeric G-quadruplex". ChemMedChem 10 5 (2015): 836-849. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928492026&partnerID=MN8TOARS.
    10.1002/cmdc.201500067
  50. Lavrado, J.; Brito, H.; Borralho, P.M.; Ohnmacht, S.A.; Kim, N.-S.; Leitão, C.; Pisco, S.; et al. "KRAS oncogene repression in colon cancer cell lines by G-quadruplex binding indolo[3,2-c]quinolines". Scientific Reports 5 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84927944758&partnerID=MN8TOARS.
    10.1038/srep09696
  51. Figueiras, M.; Coelho, L.; Wicht, K.J.; Santos, S.A.; Lavrado, J.; Gut, J.; Rosenthal, P.J.; et al. "N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: Design, synthesis and antiplasmodial activity". Bioorganic and Medicinal Chemistry 23 7 (2015): 1530-1539. http://www.scopus.com/inward/record.url?eid=2-s2.0-84925522084&partnerID=MN8TOARS.
    10.1016/j.bmc.2015.02.007
  52. Rodrigues, C.A.B.; Frade, R.F.M.; Albuquerque, I.S.; Perry, M.J.; Gut, J.; Machado, M.; Rosenthal, P.J.; et al. "Targeting the erythrocytic and liver stages of malaria parasites with s-triazine-based hybrids". ChemMedChem 10 5 (2015): 883-890. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928476505&partnerID=MN8TOARS.
    10.1002/cmdc.201500011
  53. Carvalho, L.A.R.; Ruivo, E.F.P.; Lucas, S.D.; Moreira, R.. "Activity-based probes as molecular tools for biomarker discovery". MedChemComm 6 4 (2015): 536-546. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928017209&partnerID=MN8TOARS.
    10.1039/c4md00417e
  54. Sousa, T.; Castro, R.E.; Pinto, S.N.; Coutinho, A.; Lucas, S.D.; Moreira, R.; Rodrigues, C.M.P.; Prieto, M.; Fernandes, F.. "Deoxycholic acid modulates cell death signaling through changes in mitochondrial membrane properties". Journal of Lipid Research 56 11 (2015): 2158-2171. http://www.scopus.com/inward/record.url?eid=2-s2.0-84948844490&partnerID=MN8TOARS.
    10.1194/jlr.M062653
  55. Areias, L.R.P.; Ruivo, E.F.P.; Gonçalves, L.M.; Duarte, M.T.; André, V.; Moreira, R.; Lucas, S.D.; Guedes, R.C.. "A unified approach toward the rational design of selective low nanomolar human neutrophil elastase inhibitors". RSC Advances 5 64 (2015): 51717-51721. http://www.scopus.com/inward/record.url?eid=2-s2.0-84935011743&partnerID=MN8TOARS.
    10.1039/c5ra07783d
  56. Pereira, N.A.L.; Monteiro, Â.; Machado, M.; Gut, J.; Molins, E.; Perry, M.J.; Dourado, J.; et al. "Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites". ChemMedChem 10 12 (2015): 2080-2089. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951573479&partnerID=MN8TOARS.
    10.1002/cmdc.201500429
  57. Lucas, S.D.; Carrasco, M.P.; Gonçalves, L.M.; Moreira, R.; Guedes, R.C.. "Discovery of C-shaped aurone human neutrophil elastase inhibitors". MedChemComm 6 8 (2015): 1508-1512. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938874460&partnerID=MN8TOARS.
    10.1039/c5md00164a
  58. Santos, S.A.; Lukens, A.K.; Coelho, L.; Nogueira, F.; Wirth, D.F.; Mazitschek, R.; Moreira, R.; Paulo, A.. "Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype". European Journal of Medicinal Chemistry 102 (2015): 320-333. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939606151&partnerID=MN8TOARS.
    10.1016/j.ejmech.2015.07.047
  59. Oliveira, R.; Miranda, D.; Magalhães, J.; Capela, R.; Perry, M.J.; O'Neill, P.M.; Moreira, R.; Lopes, F.. "From hybrid compounds to targeted drug delivery in antimalarial therapy". Bioorganic and Medicinal Chemistry 23 16 (2015): 5120-5130. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938951204&partnerID=MN8TOARS.
    10.1016/j.bmc.2015.04.017
  60. Hofbauer, S.; Brito, J.A.; Mulchande, J.; Nogly, P.; Pessanha, M.; Moreira, R.; Archer, M.. "Stabilization of porcine pancreatic elastase crystals by glutaraldehyde cross-linking". Acta Crystallographica Section:F Structural Biology Communications 71 (2015): 1346-1351. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944272049&partnerID=MN8TOARS.
    10.1107/S2053230X15017045
  61. de Sousa, Tania Patricia Marques; Castro, Rui E.; Pinto, Sandra N.; Coutinho, Ana; Lucas, Susana D.; Moreira, Rui; Rodrigues, Cecilia M. P.; Prieto, Manuel; Fernandes, Fabio. "The Cytotoxic Bile Acid DCA Modulates Apoptotic Signalling through Alteration of Mitochondrial Membrane Properties". Biophysical Journal (2015): https://publons.com/wos-op/publon/6375382/.
    10.1016/J.BPJ.2014.11.1342
  62. Zancajo, V.M.R.; Brito, J.; Carrasco, M.P.; Bronze, M.R.; Moreira, R.; Lopes, A.. "Analytical profiles of "legal highs" containing cathinones available in the area of Lisbon, Portugal". Forensic Science International 244 (2014): 102-110. http://www.scopus.com/inward/record.url?eid=2-s2.0-84929651155&partnerID=MN8TOARS.
    10.1016/j.forsciint.2014.08.010
  63. Amorim Madeira, P.J.; Sitoe, A.R.F.; Gonçalves, D.; Rodrigues, T.; Guedes, R.C.; Lopes, F.; Moreira, R.; Bronze, M.R.. "Antiplasmodial drugs in the gas phase: A CID and DFT study of Quinolon-4(1H)-imine derivatives". Journal of the American Society for Mass Spectrometry 25 9 (2014): 1650-1661. http://www.scopus.com/inward/record.url?eid=2-s2.0-84905716107&partnerID=MN8TOARS.
    10.1007/s13361-014-0940-x
  64. Paulo, A.; Figueiras, M.; MacHado, M.; Charneira, C.; Lavrado, J.; Santos, S.A.; Lopes, D.; et al. "Bis-alkylamine indolo[3,2- B ]quinolines as hemozoin ligands: Implications for antimalarial cytostatic and cytocidal activities". Journal of Medicinal Chemistry 57 8 (2014): 3295-3313. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899520888&partnerID=MN8TOARS.
    10.1021/jm500075d
  65. Miranda, D.; Capela, R.; Albuquerque, I.S.; Meireles, P.; Paiva, I.; Nogueira, F.; Amewu, R.; et al. "Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities". ACS Medicinal Chemistry Letters 5 2 (2014): 108-112. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894075620&partnerID=MN8TOARS.
    10.1021/ml4002985
  66. Carrasco, M.P.; Newton, A.S.; Gonçalves, L.; Góis, A.; Machado, M.; Gut, J.; Nogueira, F.; et al. "Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity". European Journal of Medicinal Chemistry 80 (2014): 523-534. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899988228&partnerID=MN8TOARS.
    10.1016/j.ejmech.2014.04.076
  67. Ribeiro, C.J.A.; Amaral, J.D.; Rodrigues, C.M.P.; Moreira, R.; Santos, M.M.M.. "Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents". Bioorganic and Medicinal Chemistry 22 1 (2014): 577-584. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891490447&partnerID=MN8TOARS.
    10.1016/j.bmc.2013.10.048
  68. Oliveira, R.; Guedes, R.C.; Meireles, P.; Albuquerque, I.S.; Gonçalves, L.M.; Pires, E.; Bronze, M.R.; et al. "Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials". Journal of Medicinal Chemistry 57 11 (2014): 4916-4923. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902449185&partnerID=MN8TOARS.
    10.1021/jm5004528
  69. Lucas, S.D.; Costa, E.; Guedes, R.C.; Moreira, R.. "Targeting COPD: Advances on low-molecular-weight inhibitors of human neutrophil elastase". Medicinal Research Reviews 33 SUPPL. 1 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84876844793&partnerID=MN8TOARS.
    10.1002/med.20247
  70. Hanson, K.K.; Ressurreicao, A.S.; Buchholz, K.; Prudencio, M.; Herman-Ornelas, J.D.; Rebelo, M.; Beatty, W.L.; et al. "Torins are potent antimalarials that block replenishment of Plasmodium liver stage parasitophorous vacuole membrane proteins". Proceedings of the National Academy of Sciences of the United States of America 110 30 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880650998&partnerID=MN8TOARS.
    10.1073/pnas.1306097110
  71. Oliveira, R.; Newton, A.S.; Guedes, R.C.; Miranda, D.; Amewu, R.K.; Srivastava, A.; Gut, J.; et al. "An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites". ChemMedChem 8 9 (2013): 1528-1536. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883052282&partnerID=MN8TOARS.
    10.1002/cmdc.201300202
  72. Mello-Vieira, J.; Sousa, T.; Coutinho, A.; Fedorov, A.; Lucas, S.D.; Moreira, R.; Castro, R.E.; et al. "Cytotoxic bile acids, but not cytoprotective species, inhibit the ordering effect of cholesterol in model membranes at physiologically active concentrations". Biochimica et Biophysica Acta - Biomembranes 1828 9 (2013): 2152-2163. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879241584&partnerID=MN8TOARS.
    10.1016/j.bbamem.2013.05.021
  73. Montalbano, F.; Cal, P.M.S.D.; Carvalho, M.A.B.R.; Gonçalves, L.M.; Lucas, S.D.; Guedes, R.C.; Veiros, L.F.; Moreira, R.; Gois, P.M.P.. "Discovery of new heterocycles with activity against human neutrophile elastase based on a boron promoted one-pot assembly reaction". Organic and Biomolecular Chemistry 11 27 (2013): 4465-4472. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881039183&partnerID=MN8TOARS.
    10.1039/c3ob40614h
  74. Carrasco, M.P.; Gut, J.; Rodrigues, T.; Ribeiro, M.H.L.; Lopes, F.; Rosenthal, P.J.; Moreira, R.; Dos Santos, D.J.V.A.. "Exploring the molecular basis of Qobc1complex inhibitors activity to find novel antimalarials hits". Molecular Informatics 32 7 (2013): 659-670. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880276957&partnerID=MN8TOARS.
    10.1002/minf.201300024
  75. Guerreiro, L.R.; Carreiro, E.P.; Fernandes, L.; Cardote, T.A.F.; Moreira, R.; Caldeira, A.T.; Guedes, R.C.; Burke, A.J.. "Five-membered iminocyclitol a-glucosidase inhibitors: Synthetic, biological screening and in silico studies". Bioorganic and Medicinal Chemistry 21 7 (2013): 1911-1917. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875211152&partnerID=MN8TOARS.
    10.1016/j.bmc.2013.01.030
  76. Rodrigues, T.; Ressurreição, A.S.; Da Cruz, F.P.; Albuquerque, I.S.; Gut, J.; Carrasco, M.P.; Gonçalves, D.; et al. "Flavones as isosteres of 4(1H)-quinolones: Discovery of ligand efficient and dual stage antimalarial lead compounds". European Journal of Medicinal Chemistry 69 (2013): 872-880. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885342864&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.09.008
  77. Mugumbate, G.; Newton, A.S.; Rosenthal, P.J.; Gut, J.; Moreira, R.; Chibale, K.; Guedes, R.C.. "Novel anti-Plasmodial hits identified by virtual screening of the ZINC database". Journal of Computer-Aided Molecular Design 27 10 (2013): 859-871. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890562071&partnerID=MN8TOARS.
    10.1007/s10822-013-9685-z
  78. Lucas, S.D.; Gonçalves, L.M.; Carvalho, L.A.R.; Correia, H.F.; Da Costa, E.M.R.; Guedes, R.A.; Moreira, R.; Guedes, R.C.. "Optimization of O3-acyl kojic acid derivatives as potent and selective human neutrophil elastase inhibitors". Journal of Medicinal Chemistry 56 23 (2013): 9802-9806. http://www.scopus.com/inward/record.url?eid=2-s2.0-84890506159&partnerID=MN8TOARS.
    10.1021/jm4011725
  79. Rodrigues, T.; Da Cruz, F.P.; Lafuente-Monasterio, M.J.; Gonçalves, D.; Ressurreição, A.S.; Sitoe, A.R.; Bronze, M.R.; et al. "Quinolin-4(1 H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria". Journal of Medicinal Chemistry 56 11 (2013): 4811-4815. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879038195&partnerID=MN8TOARS.
    10.1021/jm400246e
  80. Ribeiro, C.J.A.; Kumar, S.P.; Gut, J.; Gonçalves, L.M.; Rosenthal, P.J.; Moreira, R.; Santos, M.M.M.. "Squaric acid/4-aminoquinoline conjugates: Novel potent antiplasmodial agents". European Journal of Medicinal Chemistry 69 (2013): 365-372. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884620898&partnerID=MN8TOARS.
    10.1016/j.ejmech.2013.08.037
  81. Ressurreição, A.S.; Gonçalves, D.; Sitoe, A.R.; Albuquerque, I.S.; Gut, J.; Góis, A.; Gonçalves, L.M.; et al. "Structural optimization of quinolon-4(1 H)-imines as dual-stage antimalarials: Toward increased potency and metabolic stability". Journal of Medicinal Chemistry 56 19 (2013): 7679-7690. http://www.scopus.com/inward/record.url?eid=2-s2.0-84885635225&partnerID=MN8TOARS.
    10.1021/jm4011466
  82. Lavrado, J.; Borralho, P.M.; Ohnmacht, S.A.; Castro, R.E.; Rodrigues, C.M.P.; Moreira, R.; Dos Santos, D.J.V.A.; Neidle, S.; Paulo, A.. "Synthesis, G-quadruplex stabilisation, docking studies, and effect on cancer cells of indolo[3,2-b]quinolines with one, two, or three basic side chains". ChemMedChem 8 10 (2013): 1648-1661. http://www.scopus.com/inward/record.url?eid=2-s2.0-84884950457&partnerID=MN8TOARS.
    10.1002/cmdc.201300288
  83. Santos, D.M.; Santos, M.M.M.; Moreira, R.; Solá, S.; Rodrigues, C.M.P.. "Synthetic condensed 1,4-naphthoquinone derivative shifts neural stem cell differentiation by regulating redox state". Molecular Neurobiology 47 1 (2013): 313-324. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872501397&partnerID=MN8TOARS.
    10.1007/s12035-012-8353-y
  84. Vale, N.; Fernandes, I.; Moreira, R.; Mateus, N.; Gomes, P.. "Comparative analysis of in vitro rat liver metabolism of the antimalarial primaquine and a derived imidazoquine". Drug Metabolism Letters 6 1 (2012): 15-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864935570&partnerID=MN8TOARS.
    10.2174/187231212800229273
  85. Rocha E Silva, L.F.; Montoia, A.; Amorim, R.C.N.; Melo, M.R.; Henrique, M.C.; Nunomura, S.M.; Costa, M.R.F.; et al. "Comparative in vitro and in vivo antimalarial activity of the indole alkaloids ellipticine, olivacine, cryptolepine and a synthetic cryptolepine analog". Phytomedicine 20 1 (2012): 71-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870433022&partnerID=MN8TOARS.
    10.1016/j.phymed.2012.09.008
  86. Da Cruz, F.P.; Martin, C.; Buchholz, K.; Lafuente-Monasterio, M.J.; Rodrigues, T.; Sönnichsen, B.; Moreira, R.; et al. "Drug screen targeted at plasmodium liver stages identifies a potent multistage antimalarial drug". Journal of Infectious Diseases 205 8 (2012): 1278-1286. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859080629&partnerID=MN8TOARS.
    10.1093/infdis/jis184
  87. Rodrigues, T.; Prudêncio, M.; Moreira, R.; Mota, M.M.; Lopes, F.. "Targeting the liver stage of malaria parasites: A yet unmet goal". Journal of Medicinal Chemistry 55 3 (2012): 995-1012. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856909677&partnerID=MN8TOARS.
    10.1021/jm201095h
  88. Ribeiro, C.J.A.; Praveen Kumar, S.; Moreira, R.; Santos, M.M.M.. "Efficient synthesis of spiroisoxazoline oxindoles". Tetrahedron Letters 53 3 (2012): 281-284. http://www.scopus.com/inward/record.url?eid=2-s2.0-83555174553&partnerID=MN8TOARS.
    10.1016/j.tetlet.2011.10.139
  89. Montalbano, F.; Candeias, N.R.; Veiros, L.F.; André, V.; Duarte, M.T.; Bronze, M.R.; Moreira, R.; Gois, P.M.P.. "Four-component assembly of chiral N-B heterocycles with a natural product-like framework". Organic Letters 14 4 (2012): 988-991. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857215037&partnerID=MN8TOARS.
    10.1021/ol203224n
  90. Rodrigues, T.; Lopes, F.; Moreira, R.. "Microwave-assisted wittig reaction of semistabilized nitro-substituted benzyltriphenyl-phosphorous ylides with aldehydes in phase-transfer conditions". Synthetic Communications 42 5 (2012): 747-755. http://www.scopus.com/inward/record.url?eid=2-s2.0-80755130326&partnerID=MN8TOARS.
    10.1080/00397911.2010.530378
  91. Santana, A.B.; Lucas, S.D.; Gonçalves, L.M.; Correia, H.F.; Cardote, T.A.F.; Guedes, R.C.; Iley, J.; Moreira, R.. "N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases". Bioorganic and Medicinal Chemistry Letters 22 12 (2012): 3993-3997. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861571200&partnerID=MN8TOARS.
    10.1016/j.bmcl.2012.04.093
  92. Matos, J.; Da Cruz, F.P.; Cabrita, É.; Gut, J.; Nogueira, F.; Do Rosário, V.E.; Moreira, R.; et al. "Novel potent metallocenes against liver stage malaria". Antimicrobial Agents and Chemotherapy 56 3 (2012): 1564-1570. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857165822&partnerID=MN8TOARS.
    10.1128/AAC.05345-11
  93. Vale-Costa, S.; Vale, N.; Matos, J.; Tomás, A.; Moreira, R.; Gomes, P.; Gomes, M.S.. "Peptidomimetic and organometallic derivatives of primaquine active against Leishmania infantum". Antimicrobial Agents and Chemotherapy 56 11 (2012): 5774-5781. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868022360&partnerID=MN8TOARS.
    10.1128/AAC.00873-12
  94. Kumar, S.P.; Glória, P.M.C.; Gonalves, L.M.; Gut, J.; Rosenthal, P.J.; Moreira, R.; Santos, M.M.M.. "Squaric acid: A valuable scaffold for developing antimalarials?". MedChemComm 3 4 (2012): 489-493. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859408800&partnerID=MN8TOARS.
    10.1039/c2md20011b
  95. Lucas, S.D.; Gonçalves, L.M.; Cardote, T.A.F.; Correia, H.F.; Moreira, R.; Guedes, R.C.. "Structure based virtual screening for discovery of novel human neutrophil elastase inhibitors". MedChemComm 3 10 (2012): 1299-1304. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866983101&partnerID=MN8TOARS.
    10.1039/c2md20090b
  96. Lavrado, J.; Paulo, A.; Bichenkova, E.; Douglas, K.T.; Moreira, R.. "1H NMR spectroscopic identification of protonable sites in cryptolepines with C-11 substituents containing two amino functionalities". Magnetic Resonance in Chemistry 50 3 (2012): 216-220. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859421741&partnerID=MN8TOARS.
    10.1002/mrc.2873
  97. Mata, G.; Do Rosário, V.E.; Iley, J.; Constantino, L.; Moreira, R.. "A carbamate-based approach to primaquine prodrugs: Antimalarial activity, chemical stability and enzymatic activation". Bioorganic and Medicinal Chemistry 20 2 (2012): 886-892. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855803114&partnerID=MN8TOARS.
    10.1016/j.bmc.2011.11.059
  98. Lavrado, J.; MacKey, Z.; Hansell, E.; McKerrow, J.H.; Paulo, A.; Moreira, R.. "Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives". Bioorganic and Medicinal Chemistry Letters 22 19 (2012): 6256-6260. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866368999&partnerID=MN8TOARS.
    10.1016/j.bmcl.2012.07.104
  99. Rodrigues, T.; Moreira, R.; Lopes, F.. "New hope in the fight against malaria?". Future Medicinal Chemistry 3 1 (2011): 1-3. http://www.scopus.com/inward/record.url?eid=2-s2.0-78650654244&partnerID=MN8TOARS.
    10.4155/fmc.10.274
  100. Mulchande, J.; Simões, S.I.; Gaspar, M.M.; Eleutéio, C.V.; Oliveira, R.; Cruz, M.E.M.; Moreira, R.; Iley, J.. "Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-ß-lactam inhibitor of human leukocyte elastase". Journal of Enzyme Inhibition and Medicinal Chemistry 26 2 (2011): 169-175. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952059337&partnerID=MN8TOARS.
    10.3109/14756366.2010.486794
  101. Rodrigues, T.; Dos Santos, D.J.V.A.; Moreira, R.; Lopes, F.; Guedes, R.C.. "A quantum mechanical study of novel potential inhibitors of cytochrome bc1 as antimalarial compounds". International Journal of Quantum Chemistry 111 6 (2011): 1196-1207. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952142347&partnerID=MN8TOARS.
    10.1002/qua.22741
  102. Glória, P.M.C.; Coutinho, I.; Gonçalves, L.M.; Baptista, C.; Soares, J.; Newton, A.S.; Moreira, R.; Saraiva, L.; Santos, M.M.M.. "Aspartic vinyl sulfones: Inhibitors of a caspase-3-dependent pathway". European Journal of Medicinal Chemistry 46 6 (2011): 2141-2146. http://www.scopus.com/inward/record.url?eid=2-s2.0-79955606938&partnerID=MN8TOARS.
    10.1016/j.ejmech.2011.02.067
  103. Glória, P.M.C.; Gut, J.; Gonalves, L.M.; Rosenthal, P.J.; Moreira, R.; Santos, M.M.M.. "Aza vinyl sulfones: Synthesis and evaluation as antiplasmodial agents". Bioorganic and Medicinal Chemistry 19 24 (2011): 7635-7642. http://www.scopus.com/inward/record.url?eid=2-s2.0-82255183034&partnerID=MN8TOARS.
    10.1016/j.bmc.2011.10.018
  104. Estácio, S.G.; Moreira, R.; Guedes, R.C.. "Characterizing the dynamics and ligand-specific interactions in the human leukocyte elastase through molecular dynamics simulations". Journal of Chemical Information and Modeling 51 7 (2011): 1690-1702. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960707811&partnerID=MN8TOARS.
    10.1021/ci200076k
  105. Capela, R.; Cabal, G.G.; Rosenthal, P.J.; Gut, J.; Mota, M.M.; Moreira, R.; Lopes, F.; Prudêncio, M.. "Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy". Antimicrobial Agents and Chemotherapy 55 10 (2011): 4698-4706. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052865308&partnerID=MN8TOARS.
    10.1128/AAC.05133-11
  106. Praveen Kumar, S.; Gut, J.; Guedes, R.C.; Rosenthal, P.J.; Santos, M.M.M.; Moreira, R.. "Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials". European Journal of Medicinal Chemistry 46 3 (2011): 927-933. http://www.scopus.com/inward/record.url?eid=2-s2.0-79951677625&partnerID=MN8TOARS.
    10.1016/j.ejmech.2011.01.008
  107. Rodrigues, T.; Moreira, R.; Gut, J.; Rosenthal, P.J.; O'Neill, P.M.; Biagini, G.A.; Lopes, F.; Dos Santos, D.J.V.A.; Guedes, R.C.. "Identification of new antimalarial leads by use of virtual screening against cytochrome bc1". Bioorganic and Medicinal Chemistry 19 21 (2011): 6302-6308. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054911881&partnerID=MN8TOARS.
    10.1016/j.bmc.2011.09.004
  108. Lavrado, J.; Cabal, G.G.; Prudêncio, M.; Mota, M.M.; Gut, J.; Rosenthal, P.J.; Díaz, C.; et al. "Incorporation of basic side chains into cryptolepine scaffold: Structure-antimalarial activity relationships and mechanistic studies". Journal of Medicinal Chemistry 54 3 (2011): 734-750. http://www.scopus.com/inward/record.url?eid=2-s2.0-79851504683&partnerID=MN8TOARS.
    10.1021/jm101383f
  109. Lavrado, J.; Moreira, R.; Paulo, A.. "Indoloquinolines as scaffolds for drug discovery". Current Medicinal Chemistry 17 22 (2010): 2348-2370. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955637981&partnerID=MN8TOARS.
    10.2174/092986710791698521
  110. Rodrigues, T.; Lopes, F.; Moreira, R.. "Inhibitors of the mitochondrial electron transport chain and de novo pyrimidine biosynthesis as antimalarials: The present status". Current Medicinal Chemistry 17 10 (2010): 929-956. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950637685&partnerID=MN8TOARS.
    10.2174/092986710790820660
  111. Matos, J.; Vale, N.; Collins, M.S.; Gut, J.; Rosenthal, P.J.; Cushion, M.T.; Moreira, R.; Gomes, P.. "PRIMACENES: Novel non-cytotoxic primaquine-ferrocene conjugates with anti-Pneumocystis carinii activity". MedChemComm 1 3 (2010): 199-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-79952524600&partnerID=MN8TOARS.
    10.1039/c0md00082e
  112. Santos, M.M.M.; Faria, N.; Iley, J.; Coles, S.J.; Hursthouse, M.B.; Martins, M.L.; Moreira, R.. "Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho[2,3-d]isoxazole-4,9-diones". Bioorganic and Medicinal Chemistry Letters 20 1 (2010): 193-195. http://www.scopus.com/inward/record.url?eid=2-s2.0-72049098512&partnerID=MN8TOARS.
    10.1016/j.bmcl.2009.10.137
  113. Newton, A.S.; Glória, P.M.C.; Gonalves, L.M.; Dos Santos, D.J.V.A.; Moreira, R.; Guedes, R.C.; Santos, M.M.M.. "Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study". European Journal of Medicinal Chemistry 45 9 (2010): 3858-3863. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955549664&partnerID=MN8TOARS.
    10.1016/j.ejmech.2010.05.039
  114. Mulchande, J.; Oliveira, R.; Carrasco, M.; Gouveia, L.; Guedes, R.C.; Iley, J.; Moreira, R.. "4-Oxo-ß-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase". Journal of Medicinal Chemistry 53 1 (2010): 241-253. http://www.scopus.com/inward/record.url?eid=2-s2.0-74849100941&partnerID=MN8TOARS.
    10.1021/jm901082k
  115. Lavrado, J.; Gani, K.; Nobre, P.A.; Santos, S.A.; Figueiredo, P.; Lopes, D.; Rosário, V.D.; et al. "Bis-alkylamine quindolone derivatives as new antimalarial leads". Bioorganic and Medicinal Chemistry Letters 20 19 (2010): 5634-5637. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957554431&partnerID=MN8TOARS.
    10.1016/j.bmcl.2010.08.043
  116. Lavrado, J.; Reszka, A.P.; Moreira, R.; Neidle, S.; Paulo, A.. "C-11 diamino cryptolepine derivatives NSC748392, NSC748393, and NSC748394: Anticancer profile and G-quadruplex stabilization". Bioorganic and Medicinal Chemistry Letters 20 23 (2010): 7042-7045. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149284692&partnerID=MN8TOARS.
    10.1016/j.bmcl.2010.09.110
  117. Castro, R.E.; Santos, M.M.M.; Glória, P.M.C.; Ribeiro, C.J.A.; Ferreira, D.M.S.; Xavier, J.M.; Moreira, R.; Rodrigues, C.M.P.. "Cell death targets and potential modulators in alzheimer's disease". Current Pharmaceutical Design 16 25 (2010): 2851-2864. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957958533&partnerID=MN8TOARS.
  118. Martins, T.M.; Gonçalves, L.M.D.; Capela, R.; Moreira, R.; do Rosário, V.E.; Domingos, A.. "Effect of synthesized inhibitors on Babesipain-1, a new cysteine protease from the bovine piroplasm Babesia bigemina". Transboundary and Emerging Diseases 57 1-2 (2010): 68-69. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954450507&partnerID=MN8TOARS.
    10.1111/j.1865-1682.2010.01102.x
  119. Gibbons, P.; Verissimo, E.; Araujo, N.C.; Barton, V.; Nixon, G.L.; Amewu, R.K.; Chadwick, J.; et al. "Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: Toward combination chemotherapy of malaria through a single chemical entity". Journal of Medicinal Chemistry 53 22 (2010): 8202-8206. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649526279&partnerID=MN8TOARS.
    10.1021/jm1009567
  120. Vale, N.; Prudêncio, M.; Marques, C.A.; Collins, M.S.; Gut, J.; Nogueira, F.; Matos, J.; et al. "Imidazoquines as antimalarial and antipneumocystis agents". Journal of Medicinal Chemistry 52 23 (2009): 7800-7807. http://www.scopus.com/inward/record.url?eid=2-s2.0-72249095184&partnerID=MN8TOARS.
    10.1021/jm900738c
  121. Santos, D.M.; Santos, M.M.M.; Viana, R.J.S.; Castro, R.E.; Moreira, R.; Rodrigues, C.M.P.. "Naphtho[2,3-d]isoxazole-4,9-dione-3-carboxylates: Potent, non-cytotoxic, antiapoptotic agents". Chemico-Biological Interactions 180 2 (2009): 175-182. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349174541&partnerID=MN8TOARS.
    10.1016/j.cbi.2009.03.007
  122. Vale, N.; Nogueira, F.; do Rosário, V.E.; Gomes, P.; Moreira, R.. "Primaquine dipeptide derivatives bearing an imidazolidin-4-one moiety at the N-terminus as potential antimalarial prodrugs". European Journal of Medicinal Chemistry 44 6 (2009): 2506-2516. http://www.scopus.com/inward/record.url?eid=2-s2.0-64249118390&partnerID=MN8TOARS.
    10.1016/j.ejmech.2009.01.018
  123. Vale, N.; Moreira, R.; Gomes, P.. "Primaquine revisited six decades after its discovery". European Journal of Medicinal Chemistry 44 3 (2009): 937-953. http://www.scopus.com/inward/record.url?eid=2-s2.0-60549099364&partnerID=MN8TOARS.
    10.1016/j.ejmech.2008.08.011
  124. Santos, C.R.; Capela, R.; Pereira, C.S.G.P.; Valente, E.; Gouveia, L.; Pannecouque, C.; De Clercq, E.; Moreira, R.; Gomes, P.. "Structure-activity relationships for dipeptide prodrugs of acyclovir: Implications for prodrug design". European Journal of Medicinal Chemistry 44 6 (2009): 2339-2346. http://www.scopus.com/inward/record.url?eid=2-s2.0-64249094656&partnerID=MN8TOARS.
    10.1016/j.ejmech.2008.08.009
  125. Fernandes, I.; Vale, N.; de Freitas, V.; Moreira, R.; Mateus, N.; Gomes, P.. "Anti-tumoral activity of imidazoquines, a new class of antimalarials derived from primaquine". Bioorganic and Medicinal Chemistry Letters 19 24 (2009): 6914-6917. http://www.scopus.com/inward/record.url?eid=2-s2.0-71849088617&partnerID=MN8TOARS.
    10.1016/j.bmcl.2009.10.081
  126. Capela, R.; Oliveira, R.; Gonçalves, L.M.; Domingos, A.; Gut, J.; Rosenthal, P.J.; Lopes, F.; Moreira, R.. "Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: Design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition". Bioorganic and Medicinal Chemistry Letters 19 12 (2009): 3229-3232. http://www.scopus.com/inward/record.url?eid=2-s2.0-65749094248&partnerID=MN8TOARS.
    10.1016/j.bmcl.2009.04.100
  127. Rodrigues, T.; Moreira, R.; Dacunha-Marinho, B.; Lopes, F.. "Bis{(E)-3-[(diethyl-methyl-ammonio)meth-yl]-N-[3-(N,N-dimethyl-sulfamo-yl) -1-methyl-pyridin-4-yl-idene]-4-methoxy-anilinium} tetra-iodide penta-hydrate". Acta Crystallographica Section E: Structure Reports Online 65 2 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-60349087045&partnerID=MN8TOARS.
    10.1107/S1600536809000324
  128. Rodrigues, T.; Guedes, R.C.; dos Santos, D.J.V.A.; Carrasco, M.; Gut, J.; Rosenthal, P.J.; Moreira, R.; Lopes, F.. "Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials". Bioorganic and Medicinal Chemistry Letters 19 13 (2009): 3476-3480. http://www.scopus.com/inward/record.url?eid=2-s2.0-66349136182&partnerID=MN8TOARS.
    10.1016/j.bmcl.2009.05.017
  129. Perry, M.J.; Mendes, E.; Simplício, A.L.; Coelho, A.; Soares, R.V.; Iley, J.; Moreira, R.; Francisco, A.P.. "Dopamine- and tyramine-based derivatives of triazenes: Activation by tyrosinase and implications for prodrug design". European Journal of Medicinal Chemistry 44 8 (2009): 3228-3234. http://www.scopus.com/inward/record.url?eid=2-s2.0-67349149632&partnerID=MN8TOARS.
    10.1016/j.ejmech.2009.03.025
  130. Vale, N.; Matos, J.; Moreira, R.; Gomes, P.. "Electrospray ionization mass spectrometry as a valuable tool in the characterization of novel primaquine peptidomimetic derivatives". European Journal of Mass Spectrometry 15 5 (2009): 627-640. http://www.scopus.com/inward/record.url?eid=2-s2.0-70349571582&partnerID=MN8TOARS.
    10.1255/ejms.1011
  131. Santos, Maria M. M.; Newton, Ana S.; Coutinho, Isabel; Gloria, Paulo M. C.; Saraiva, Lucilia; Moreira, Rui. "VINYL SULFONES AS CASPASE INHIBITORS". Drugs of the Future 34 (2009): 176-176.
  132. Vale, N.; Collins, M.S.; Gut, J.; Ferraz, R.; Rosenthal, P.J.; Cushion, M.T.; Moreira, R.; Gomes, P.. "Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones". Bioorganic and Medicinal Chemistry Letters 18 2 (2008): 485-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-38149054056&partnerID=MN8TOARS.
    10.1016/j.bmcl.2007.11.105
  133. Mulchande, J.; Guedes, R.C.; Tsang, W.-Y.; Page, M.I.; Moreira, R.; Iley, J.. "Azetidine-2,4-diones (4-oxo-ß-lactams) as scaffolds for designing elastase inhibitors". Journal of Medicinal Chemistry 51 6 (2008): 1783-1790. http://www.scopus.com/inward/record.url?eid=2-s2.0-41149169679&partnerID=MN8TOARS.
    10.1021/jm701257h
  134. Vale, N.; Moreira, R.; Gomes, P.. "Characterization of primaquine imidazolidin-4-ones with antimalarial activity by electrospray ionization-ion trap mass spectrometry". International Journal of Mass Spectrometry 270 1-2 (2008): 81-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-38349068373&partnerID=MN8TOARS.
    10.1016/j.ijms.2007.12.006
  135. Lavrado, J.; Paulo, A.; Gut, J.; Rosenthal, P.J.; Moreira, R.. "Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: Synthesis, antiplasmodial activity, and cytotoxicity". Bioorganic and Medicinal Chemistry Letters 18 4 (2008): 1378-1381. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949089316&partnerID=MN8TOARS.
    10.1016/j.bmcl.2008.01.015
  136. Santos, C.; Morais, J.; Gouveia, L.; De Clercq, E.; Pannecouque, C.; Nielsen, C.U.; Steffansen, B.; Moreira, R.; Gomes, P.. "Dipeptide derivatives of AZT: Synthesis, chemical stability, activation in human plasma, hPEPT1 affinity, and antiviral activity". ChemMedChem 3 6 (2008): 970-978. http://www.scopus.com/inward/record.url?eid=2-s2.0-48149103948&partnerID=MN8TOARS.
    10.1002/cmdc.200800012
  137. Vale, N.; Matos, J.; Moreira, R.; Gomes, P.. "Electrospray Ionization-Ion Trap Mass Spectrometry Study of PQAAPro and PQProAA Mimetic Derivatives of the Antimalarial Primaquine". Journal of the American Society for Mass Spectrometry 19 10 (2008): 1476-1490. http://www.scopus.com/inward/record.url?eid=2-s2.0-53149103554&partnerID=MN8TOARS.
    10.1016/j.jasms.2008.06.019
  138. Vale, N.; Matos, J.; Gut, J.; Nogueira, F.; do Rosário, V.; Rosenthal, P.J.; Moreira, R.; Gomes, P.. "Imidazolidin-4-one peptidomimetic derivatives of primaquine: Synthesis and antimalarial activity". Bioorganic and Medicinal Chemistry Letters 18 14 (2008): 4150-4153. http://www.scopus.com/inward/record.url?eid=2-s2.0-47149096687&partnerID=MN8TOARS.
    10.1016/j.bmcl.2008.05.076
  139. Martinelli, A.; Moreira, R.; Cravo, P.V.L.. "Malaria combination therapies: Advantages and shortcomings". Mini-Reviews in Medicinal Chemistry 8 3 (2008): 201-212. http://www.scopus.com/inward/record.url?eid=2-s2.0-42449137053&partnerID=MN8TOARS.
    10.2174/138955708783744092
  140. Rodrigues, T.; Moreira, R.; Guedes, R.C.; Iley, J.; Lopes, F.. "Unanticipated acyloxymethylation of sumatriptan indole nitrogen atom and its implications in prodrug design". Archiv der Pharmazie 341 6 (2008): 344-350. http://www.scopus.com/inward/record.url?eid=2-s2.0-50949107913&partnerID=MN8TOARS.
    10.1002/ardp.200700250
  141. Vale, N.; Matos, J.; Moreira, R.; Gomes, P.. "Amino acids as selective acylating agents: regioselective N1-acylation of imidazolidin-4-one derivatives of the antimalarial drug primaquine". Tetrahedron 64 49 (2008): 11144-11149. http://www.scopus.com/inward/record.url?eid=2-s2.0-54549090856&partnerID=MN8TOARS.
    10.1016/j.tet.2008.09.058
  142. Ribeiro, L.; Silva, N.; Iley, J.; Rautio, J.; Järvinen, T.; Mota-Filipe, H.; Moreira, R.; Mendes, E.. "Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: Suppressing the rearrangement pathway in aqueous media". Archiv der Pharmazie 340 1 (2007): 32-40. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846547138&partnerID=MN8TOARS.
    10.1002/ardp.200600145
  143. Oliveira, T.F.; Mulchande, J.; Moreira, R.; Iley, J.; Archer, M.. "Crystallization and preliminary diffraction studies of porcine pancreatic elastase in complex with a novel inhibitor". Protein and Peptide Letters 14 1 (2007): 93-95. http://www.scopus.com/inward/record.url?eid=2-s2.0-33845990604&partnerID=MN8TOARS.
    10.2174/092986607779117173
  144. Gomes, P.; Vale, N.; Moreira, R.. "Cyclization-activated prodrugs". Molecules 12 11 (2007): 2484-2506. http://www.scopus.com/inward/record.url?eid=2-s2.0-36849072605&partnerID=MN8TOARS.
    10.3390/12112484
  145. Santos, M.M.M.; Moreira, R.. "Michael acceptors as cysteine protease inhibitors". Mini-Reviews in Medicinal Chemistry 7 10 (2007): 1040-1050. http://www.scopus.com/inward/record.url?eid=2-s2.0-35048878659&partnerID=MN8TOARS.
    10.2174/138955707782110105
  146. Valente, C.; Moreira, R.; Guedes, R.C.; Iley, J.; Jaffar, M.; Douglas, K.T.. "The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors". Bioorganic and Medicinal Chemistry 15 15 (2007): 5340-5350. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249989417&partnerID=MN8TOARS.
    10.1016/j.bmc.2007.04.068
  147. Mulchande, J.; Martins, L.; Moreira, R.; Archer, M.; Oliveira, T.F.; Iley, J.. "The efficiency of C-4 substituents in activating the ß-lactam scaffold towards serine proteases and hydroxide ion". Organic and Biomolecular Chemistry 5 16 (2007): 2617-2626. http://www.scopus.com/inward/record.url?eid=2-s2.0-34547602336&partnerID=MN8TOARS.
    10.1039/b706622h
  148. Ferraz, R.; Gomes, J.R.B.; De Oliveira, E.; Moreira, R.; Gomes, P.. "Unanticipated stereoselectivity in the reaction of primaquine a-aminoamides with substituted benzaldehydes: A computational and experimental study". Journal of Organic Chemistry 72 11 (2007): 4189-4197. http://www.scopus.com/inward/record.url?eid=2-s2.0-34249810396&partnerID=MN8TOARS.
    10.1021/jo0703202
  149. Valente, C.; Guedes, R.C.; Moreira, R.; Iley, J.; Gut, J.; Rosenthal, P.J.. "Dipeptide vinyl sultams: Synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum". Bioorganic and Medicinal Chemistry Letters 16 15 (2006): 4115-4119. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745242354&partnerID=MN8TOARS.
    10.1016/j.bmcl.2006.04.079
  150. Chambel, P.; Capela, R.; Lopes, F.; Iley, J.; Morais, J.; Gouveia, L.; Gomes, J.R.B.; Gomes, P.; Moreira, R.. "Reactivity of imidazolidin-4-one derivatives of primaquine: implications for prodrug design". Tetrahedron 62 42 (2006): 9883-9891. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748140661&partnerID=MN8TOARS.
    10.1016/j.tet.2006.08.026
  151. Iley, J.; Moreira, R.; Martins, L.; Guedes, R.C.; Soares, C.M.. "The Bsmoc group as a novel scaffold for the design of irreversible inhibitors of cysteine proteases". Bioorganic and Medicinal Chemistry Letters 16 10 (2006): 2738-2741. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645857658&partnerID=MN8TOARS.
    10.1016/j.bmcl.2006.02.007
  152. Santos, C.; Mateus, M.L.; Dos Santos, A.P.; Moreira, R.; De Oliveira, E.; Gomes, P.. "Cyclization-activated prodrugs. Synthesis, reactivity and toxicity of dipeptide esters of paracetamol". Bioorganic and Medicinal Chemistry Letters 15 6 (2005): 1595-1598. http://www.scopus.com/inward/record.url?eid=2-s2.0-14644436965&partnerID=MN8TOARS.
    10.1016/j.bmcl.2005.01.065
  153. Moreira, R.; Santana, A.B.; Iley, J.; Neres, J.; Douglas, K.T.; Horton, P.N.; Hursthouse, M.B.. "Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted ß-lactams as novel inhibitors of human leukocyte elastase". Journal of Medicinal Chemistry 48 15 (2005): 4861-4870. http://www.scopus.com/inward/record.url?eid=2-s2.0-22744432247&partnerID=MN8TOARS.
    10.1021/jm0501331
  154. Araújo, M.J.; Bom, J.; Capela, R.; Casimiro, C.; Chambel, P.; Gomes, P.; Iley, J.; et al. "Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials". Journal of Medicinal Chemistry 48 3 (2005): 888-892. http://www.scopus.com/inward/record.url?eid=2-s2.0-13444269006&partnerID=MN8TOARS.
    10.1021/jm0494624
  155. Fernandes, C.; Patrício, L.; Moreira, R.; Cantinho, G.; Pena, H.; Campello, P.C.; Santos, I.. "Novel 3+1 mixed-ligand Technetium-99m complexes carrying dipeptides as monodentate ligands". Nuclear Medicine and Biology 31 1 (2004): 139-145. http://www.scopus.com/inward/record.url?eid=2-s2.0-1642492860&partnerID=MN8TOARS.
    10.1016/S0969-8051(03)00129-X
  156. Gomes, P.; Araújo, M.J.; Rodrigues, M.; Vale, N.; Azevedo, Z.; Iley, J.; Chambel, P.; Morais, J.; Moreira, R.. "Synthesis of imidazolidin-4-one and 1H-imidazo[2,1-a]isoindole-2,5(3H,9bH)- dione derivatives of primaquine: Scope and limitations". Tetrahedron 60 26 (2004): 5551-5562. http://www.scopus.com/inward/record.url?eid=2-s2.0-2942564073&partnerID=MN8TOARS.
    10.1016/j.tet.2004.04.077
  157. Lopes, F.; Capela, R.; Gonçaves, J.O.; Horton, P.N.; Hursthouse, M.B.; Iley, J.; Casimiro, C.M.; Bom, J.; Moreira, R.. "Amidomethylation of amodiaquine: Antimalarial N-Mannich base derivatives". Tetrahedron Letters 45 41 (2004): 7663-7666. http://www.scopus.com/inward/record.url?eid=2-s2.0-4544220004&partnerID=MN8TOARS.
    10.1016/j.tetlet.2004.08.093
  158. Valente, E.; Gomes, J.R.B.; Moreira, R.; Iley, J.. "Kinetics and Mechanism of Hydrolysis of N-Acyloxymethyl Derivatives of Azetidin-2-one". Journal of Organic Chemistry 69 10 (2004): 3359-3367. http://www.scopus.com/inward/record.url?eid=2-s2.0-2442475244&partnerID=MN8TOARS.
    10.1021/jo0358123
  159. Gomes, P.; Gomes, J.R.B.; Rodrigues, M.; Moreira, R.. "Amino acids as selective sulfonamide acylating agents". Tetrahedron 59 38 (2003): 7473-7480. http://www.scopus.com/inward/record.url?eid=2-s2.0-0041829350&partnerID=MN8TOARS.
    10.1016/S0040-4020(03)01206-7
  160. Gomes, P.; Santos, M.I.; Trigo, M.J.; Castanheiro, R.; Moreira, R.. "Improved synthesis of amino acid and dipeptide chloromethyl esters using bromochloromethane". Synthetic Communications 33 10 (2003): 1683-1693. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037569247&partnerID=MN8TOARS.
    10.1081/SCC-120018930
  161. Mendes, E.; Furtado, T.; Neres, J.; Iley, J.; Jarvinen, T.; Rautio, J.; Moreira, R.. "Synthesis, stability and in vitro dermal evaluation of aminocarbonyloxymethyl esters as prodrugs of carboxylic acid agents". Bioorganic and Medicinal Chemistry 10 3 (2002): 809-816. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036158330&partnerID=MN8TOARS.
    10.1016/S0968-0896(01)00336-4
  162. Clemente, A.; Domingos, A.; Grancho, A.P; Iley, J.; Moreira, R.; Neres, J.; Palma, N.; Santana, A.B; Valente, E.. "Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors". Bioorganic and Medicinal Chemistry Letters 11 8 (2001): 1065-1068. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035938401&partnerID=MN8TOARS.
    10.1016/S0960-894X(01)00131-7
  163. Iley, J.; Lopes, F.; Moreira, R.. "Kinetics and mechanism of hydrolysis of N-amidomethylsulfonamides". Journal of the Chemical Society, Perkin Transactions 2 5 (2001): 749-753. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035528977&partnerID=MN8TOARS.
  164. Iley, J.; Barroso, H.; Moreira, R.; Lopes, F.; Calheiros, T.. "Acyloxymethyl as a drug protecting group. Part 7: Tertiary sulfonamidomethyl ester prodrugs of benzylpenicillin: Chemical hydrolysis and anti-bacterial activity". Bioorganic and Medicinal Chemistry 8 7 (2000): 1629-1636. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033936572&partnerID=MN8TOARS.
    10.1016/S0968-0896(00)00099-7
  165. Lopes, F.; Moreira, R.; Iley, J.. "Acyloxymethyl as a drug protecting group. Part 6: N-acyloxymethyl- and N-[(aminocarbonyloxy)methyl]sulfonamides as prodrugs of agents containing a secondary sulfonamide group". Bioorganic and Medicinal Chemistry 8 4 (2000): 707-716. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034027024&partnerID=MN8TOARS.
    10.1016/S0968-0896(00)00015-8
  166. Lopes, F.; Moreira, R.; Iley, J.. "Acyloxymethyl as a drug protecting group. Part 5. Kinetics and mechanism of the hydrolysis of tertiary N-acyloxymethylsulfonamides". Journal of the Chemical Society. Perkin Transactions 2 3 (1999): 431-439. http://www.scopus.com/inward/record.url?eid=2-s2.0-0037889702&partnerID=MN8TOARS.
  167. Iley, J.; Mendes, E.; Moreira, R.; Souza, S.. "Cleavage of tertiary amidomethyl ester prodrugs of carboxylic acids by rat liver homogenates". European Journal of Pharmaceutical Sciences 9 2 (1999): 201-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033460252&partnerID=MN8TOARS.
    10.1016/S0928-0987(99)00057-3
  168. Portela, M.J.; Moreira, R.; Valente, E.; Constantino, L.; Iley, J.; Pinto, J.; Rosa, R.; Cravo, P.; Do Rosario, V.E.. "Dipeptide derivatives of primaquine as transmission-blocking antimalarials: Effect of aliphatic side-chain acylation on the gametocytocidal activity and on the formation of carboxyprimaquine in rat liver homogenates". Pharmaceutical Research 16 6 (1999): 949-955. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033020951&partnerID=MN8TOARS.
    10.1023/A:1018922425551
  169. Constantino, L.; Paixão, P.; Moreira, R.; Portela, M.J.; Do Rosario, V.E.; Iley, J.. "Metabolism of primaquine by liver homogenate fractions. Evidence for monoamine oxidase and cytochrome P450 involvement in the oxidative deamination of primaquine to carboxyprimaquine". Experimental and Toxicologic Pathology 51 4-5 (1999): 299-303. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032781772&partnerID=MN8TOARS.
    10.1016/S0940-2993(99)80010-4
  170. Iley, J.; Calheiros, T.; Moreira, R.. "Phthalimidomethyl as a drug pro-moiety. Probing its reactivity". Bioorganic and Medicinal Chemistry Letters 8 8 (1998): 955-958. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032554692&partnerID=MN8TOARS.
    10.1016/S0960-894X(98)00135-8
  171. Iley, J.; Moreira, R.; Calheiros, T.; Mendes, E.. "Acyloxymethyl as a drug protecting group: Part 4. The hydrolysis of tertiary amidomethyl-ester prodrugs of carboxylic acid agents". Pharmaceutical Research 14 11 (1997): 1634-1639. http://www.scopus.com/inward/record.url?eid=2-s2.0-6844261184&partnerID=MN8TOARS.
    10.1023/A:1012146905833
  172. Moreira, R.; Calheiros, T.; Cabrita, J.; Mendes, E.; Pimentel, M.; Iley, J.. "Acyloxymethyl as a drug protecting group. Part 3. Tertiary O-amidomethyl esters of penicillin G: Chemical hydrolysis and anti-bacterial activity". Pharmaceutical Research 13 1 (1996): 70-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029865020&partnerID=MN8TOARS.
    10.1023/A:1016077200460
  173. Calheiros, T.; Iley, J.; Lopes, F.; Moreira, R.. "Acyloxymethyl as a drug protecting group. Synthesis and reactivity of N-acyloxymethylsulfonamide prodrugs". Bioorganic and Medicinal Chemistry Letters 5 9 (1995): 937-940. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029063007&partnerID=MN8TOARS.
    10.1016/0960-894X(95)00146-K
  174. Moreira, R.; Mendes, E.; Calheiros, T.; Bacelo, M.J.; Iley, J.. "A new direct synthesis of tertiary N-acyloxymethylamide prodrugs of carboxylic acid drugs". Tetrahedron Letters 35 38 (1994): 7107-7110. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027971217&partnerID=MN8TOARS.
    10.1016/0040-4039(94)88238-X
  175. Rosa, E.; Carvalho, E.; Cheng, S.C.; Fernandes, L.; Iley, J.; Moreira, R.; Nunes, A.; Ruecroft, G.. "Antitumoral triazenes: Biological action and development of prodrugs,TRIAZENOS ANTITUMORAIS: MECANISMO DE ACCAO BIOLOGICA E DESENVOLVIMENTO DE PRO-FARMACOS". Revista Portuguesa de Farmacia 42 3 (1992): 7-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-0026478874&partnerID=MN8TOARS.
  176. Iley, J.; Moreira, R.; Rosa, E.. "Acyloxymethyl as a drug protecting group. Kinetics and mechanism of the hydrolysis of N-acyloxymethylbenzamides". Journal of the Chemical Society, Perkin Transactions 2 5 (1991): 563-570. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049084026&partnerID=MN8TOARS.
  177. Iley, J.; Moreira, R.; Rosa, E.. "Triazene drug metabolites. Part 10. Metal-ion catalysed decomposition of monoalkyltriazenes in ethanol solutions". Journal of the Chemical Society, Perkin Transactions 2 1 (1991): 81-86. http://www.scopus.com/inward/record.url?eid=2-s2.0-0005191632&partnerID=MN8TOARS.
  178. Iley, J.; Moreira, R.; Rosa, E.. "Triazene drug metabolites. Part 11. Synthesis of S-cysteinyl and related derivatives of N-hydroxymethyltriazenes". Journal of the Chemical Society, Perkin Transactions 1 12 (1991): 3241-3244. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049078261&partnerID=MN8TOARS.
  179. Iley, J.; Moreira, R.; Ruecroft, G.; Rosa, E.. "Synthesis of S-cysteinyl, S(N-acetylcysteinyl) and S-glutathionyl conjugates op N-hydroxymethyltriazenes". Tetrahedron Letters 29 22 (1988): 2707-2710. http://www.scopus.com/inward/record.url?eid=2-s2.0-45549120308&partnerID=MN8TOARS.
    10.1016/0040-4039(88)85266-3
  180. Iley, J.N.; Moreira, R.; Rosa, E.. "Triazene drug metabolites. Part 4. Kinetics and mechanism of the decomposition of 1-aryl-3-benzoyloxymethyl-3-methyltriazenes in mixed aqueous-organic solvents". Journal of the Chemical Society, Perkin Transactions 2 10 (1987): 1503-1508. http://www.scopus.com/inward/record.url?eid=2-s2.0-37049081323&partnerID=MN8TOARS.
Capítulo de livro
  1. da Silva, G.; Moreira, R.; Silva, A.M.S.. "Bioactive Quinolactacins and Structurally Related Pyrroloquinolones". 433-453. 2019.
    10.1016/B978-0-444-64185-4.00012-5
  2. Moreira, Rui; Dias, A. F.; Ressurreição, Ana Sofia. "One-Step Synthesis of 4(3H)-Quinazolinones: An Important Heterocyclic Scaffold in Medicinal Chemistry". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. The Royal Society of Chemistry, 2016.
    Publicado
  3. Moreira, Rui; Lavrado, J.; Figueiras, M.; Pereira, D. M.; Santos, S. A.; Paulo, Alexandra. "Synthesis of Indolo[3,2-b]quinolin-11-one by Acid-Catalysed Intramolecular Double Cyclization". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. The Royal Society of Chemistry, 2016.
    Publicado
  4. Moreira, Rui; Ribeiro, C.J.A.; Santos, M.M.M.. "Synthesis of a spiroisoxazoline oxindole by 1,3-dipolar Cycloaddition". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. The Royal Society of Chemistry, 2016.
    Publicado
  5. Moreira, Rui; Lucas, S.D.; Ruivo, E.F.P.; Figueiras, M.; Lavrado, J.. "Click Chemistry". In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. The Royal Society of Chemistry, 2016.
    Publicado
  6. Lopes, F.; Santos, M.M.M.; Moreira, R.. "Designing covalent inhibitors: A medicinal chemistry challenge". In Biomedical Chemistry: Current Trends and Developments, editado por Vale, Nuno. 2015.
    10.1515/9783110468755-002
  7. Sitoe, A.R.; Lopes, Francisca; Moreira, Rui; Varela Coelho, Ana; Bronze, Maria. "Contribution of Mass Spectrometry to the Study of Antimalarial Agents". In Tandem Mass Spectrometry-Molecular Characterization, editado por Varela Coelho, Ana. Polónia: IntechOpen, 2013.
    Publicado
  8. Mulchande, Jalmira; Lopes, Francisca; Moreira, Rui. "Azetidin-2-ones and related systems as enzyme inhibitors: synthesis and reactivity". In Heterocyclic Targets in Advanced Organic Synthesis, editado por Carreiras, Maria do Carmo; Marco-Contelles, J.. Research Signpost, 2011.
    Publicado
  9. Lavrado, J.; Moreira, Rui; Paulo, Alexandra. "Synthetic strategies towards bioactive indolo[3,2-b]quinolines". In Heterocyclic Targets in Advanced Organic Synthesis, editado por Carreiras, Maria do Carmo; Marco-Contelles, J.. Research Signpost, 2011.
    Publicado
  10. Francisco, A.P.; Perry, M.D.J.; Moreira, R.; Mendes, E.. "Alkylating Agents". In Anticancer Therapeutics. Chichester, Reino Unido: Wiley-Blackwell, 2008.
    10.1002/9780470697047.ch9

Propriedade Intelectual

Patente
  1. Magalhães e Silva, Diogo; Moreira, Rui; Lopes, Francisca; Rodrigues, CMP; Marques, Vanda. 2023. "Drug delivery systems based on endoperoxides useful in diagnosis and therapy, and methods thereof".
    Pendente
Pedido provisório de patente
  1. 2021. "1,2,4,5-TETRAOXANE COMPOUNDS, A DRUG DELIVERY SYSTEM BASED IN SAID COMPOUNDS USEFUL IN DIAGNOSES AND THERAPY, AND METHODS THEREOF".
    Protegido

Outros

Outra produção
  1. Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable and Blood Brain Barrier Penetrant Proteolysis Targeting Chimera Degrader of Leucine Rich Repeat Kinase 2. 2022. Liu, X.; Kalogeropulou, A.F.; Domingos, S.; Makukhin, N.; Nirujogi, R.S.; Singh, F.; Shpiro, N.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85136051007&partnerID=MN8TOARS.
    10.26434/chemrxiv-2022-4gzm0
  2. Half-sandwich cyclopentadienylruthenium(II) complexes: A new antimalarial chemotype. 2020. Milheiro, S.A.; Gonçalves, J.; Lopes, R.; Madureira, M.; Lobo, L.; Lopes, A.; Nogueira, F.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85098906570&partnerID=MN8TOARS.
    10.26434/chemrxiv.12155178.v1
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/01/30 Novel Chemical Tools to Target Ferrous Iron-Dependent Biology EU-OPENSCREEN Webinar Series 2024
EU-OPENSCREEN (Webinar)
2023/10/24 Cases Studies in Antimalarial Drug Discovery Lecture for the ISF College of Pharmacy
ISF College of Pharmacy (On-Line, Índia)
2023/10/10 Endoperoxides as chemical tools to enable precision ferrous iron-dependent pharmacology DPhG Annual Meeting 2023
DPhG (Deutsche Pharmazeutische Gesellschaft) (TÜBINGEN, Alemanha)
2023/07/17 Iron Metabolism Dysregulation: a New Target for Precision Oncology XXI Meeting of the Paul Ehrlich Euro-PhD Network
Paul Ehrlich Euro-PhD Network (Thessaloniki, Grécia)
2023/07/13 Design of Antimalarial Compounds Inspired by Natural Products III Bio.Natural- Bioactive Natural Products Research Conference
Bio.Natural (Lisbon, Portugal)
2023/07/10 New Chemical Tools to Target Therapeutically Relevant Serine Hydrolases Department Seminar
Université Côte d'Azur (Nice, França)
2023/05/10 Exploring new chemistries to finetune the selectivity of activity-base probes targeting serine hydrolases European Chemical Biology Symposium 2023
AstraZeneca (Gothenburg, Suécia)
2023/01/31 Strategies in Antimalarial Drug Discovery EU-OPENSCREEN Webinar Series 2023
EU-OPENSCREEN (On-Line)
2022/11/06 Designing chemical probes for serine hydrolases EU-OPENSCREEN - AUTUMN TRAINING SCHOOL 2022
EU-OPENSCREEN (On-Line)
2022/08/26 Targeting Iron Metabolism as a Novel Approach for Cancer Therapy VI Congress Turkish Association of Medicinal and Pharmaceutical Chemistry
Turkish Association of Medicinal and Pharmaceutical Chemistry (Istanbul, Turquia)
2022/06/22 Targeting Iron Metabolism Dysregulation for Precision Oncology XX Meeting of the Spanish Society of Medicinal Chemistry SEQT 2022
Spanish Society of Medicinal Chemistry (Santiago de Compostela, Espanha)
2022/03/09 Medicinal Chemistry in Century, Quo Vadis Inaugural Lecture of 2022 Academic Year, Fiocruz Institute
Fiocruz Institute, on-line (on-line, Brasil)
2022/01/25 Targeting Iron Metabolism for Selective Drug Delivery XXVIII Summer School Professor Eliezer Barreiro in Medicinal Chemistry
On-Line
2021/08/25 From activity-based protein profiling to the optimization of covalent inhibitors targeting dipeptidyl peptidases GP2A 2021 - 29th Annual Conference, Group for the Promotion of Pharmaceutical chemistry in Academia
Group for the Promotion of Pharmaceutical chemistry in Academia (on-ine)
2021/04/30 Chemical Tools for Hypoxia- and Ferrous Iron-Dependent Pharmacology iMed Seminar Series
2021/04/09 Design of prodrugs for targeted therapy XIV Congresso Científico NEF/AAC
On-Line
2020/05/05 Discovery of Dipeptidyl Peptidases 8 and 9 covalent inhibitors using activity-based protein profiling and structure-based drug design António V. Xavier (AVX) seminars
ITQB-NOVA (Oeiras, Portugal)
2019/12 Discovery of new DPP8 and DPP9 inhibitors via activity-based protein profiling of serine hydrolases 4th Iberoamerican Symposium on Organic Chemistry (Sibeaqo-IV)
(Cayo Santa Maria, Cuba)
2019/10 Targeting Serine Hydrolases With Novel Activity-Based Probes University Seminar
University of Gottingen (Gottingen , Alemanha)
2019/01 Target identification using chemical biology Chemistry & Biology CrossTalks
University of Lisbon (Lisboa, Portugal)
2018/03 Boron in Medicinal Chemistry and Chemical Biology 245th American Chemical Society National Meeting
American Chemical Society (New Orleans, Estados Unidos)
2017/12 Novel chemical approaches to target malaria parasites Seminar
University of Bonn (Bonn, Alemanha)
2017/11 Lead discovery for parasitic diseases 3rd Northern Postgraduate Symposium on Chemistry and Biotechnology
Postgraduate Programme on Chemistry and Biotechnology, Federal University of Alagoas (Maceió)
2017/09 From enzyme inhibitors to chemical probes: where Medicinal Chemistry and Chemical Biology meet Seminar
University of Porto (Porto, Portugal)
2017/07 Lead discovery for infectious diseases of the developing world: chemistry to unravel a black box 25th Meeting of the Portuguese Chemical Society
Portuguese Chemical Society (Lisboa, Portugal)
2017/06 Lead discovery for parasitic diseases 2nd Frontiers in Medicinal Chemistry Course
MedChemTrain PhD Programme (Penela, Portugal)
2016/11 Identification and optimization of a novel chemotype with antileishmanial and dual-stage antimalarial activities Drug Discovery and Development Centre (H3D) 2016 Symposium
Drug Discovery and Development Centre (H3D) 2016 Symposium (Worcester, África do Sul)
2015/06 Fine Tuning of Heterocycles to Discover Chemical Tools for Tropical Diseases 7th Spanish-Portuguese-Japanese Organic Chemistry Symposium
Spanish Chemical Society (Seville, Espanha)
2015/06 Drug design and screening: identifying new therapeutic targets 6th European Conference on Chemistry for Life Sciences, Protein School
EuChems Division of Life Sciences (Monte da Caparinca, Portugal)
2015/04 New medicines for malaria elimination 3rd National Meeting on Tropical Medicine
Portuguese Institute of Hygiene and Tropical Medicine (Lisboa, Portugal)
2015/02 Structural optimization of multi-stage acting endoperoxide-based hybrid antimalarials Sam Higginbottom Memorial International Lecture
Sam Higginbottom Institute of Agriculture, Technology and Science (Allahabad, Índia)
2015/02 A Chemogenomic Insight into the Discovery of Single and Dual-Stage Antimalarials 21st Indian Society of Chemists and Biologists International Conference (ISCBC-2015)
Indian Society of Chemists and Biologists (Lucknow, Índia)
2014/11 Chemogenomic Approaches to Single- and Dual-Stage Antimalarial Agents 7th Brazilian Symposium on Medicinal Chemistry (BrazMedChem2014)
(Campos do Jordão, Brasil)
2014/10 Structural optimization of multi-stage acting endoperoxide-based hybrid antimalarials Targeted Chemotherapy towards Diseases Caused by Endoparasites: COST meeting
Targeted Chemotherapy towards Diseases Caused by Endoparasites: COST action (Calvi, França)
2014/06 From Chemical Tools to Pre-Clinical Drug Discovery ChemULisboa
University of Lisbon (Lisboa, Portugal)
2014/05 Integrated Chemogenomic and In Silico Approaches to Develop Novel Antimalarial Lead Compounds Seminar
Institute of Molecular Medicine (Lis, Portugal)
2014/04 In Silico Discovery of Human Neutrophil Elastase Inhibitors for the Treatment of COPD 7th National Meeting of Biochemistry Students
(Monte da Caparica, Portugal)
2013/09 New Chemical Tools to Study the Biology of Malaria 10th National Meeting on Organic Chemistry
Portuguese Chemical Society Division of Organic Chemistry (Lisboa, Portugal)
2013/06 Targeting the liver and blood stages of malaria parasites with small and not-so-small molecules Seminar
University of California San Francisco, San Francisco General Hospital (San Francisco, Estados Unidos)
2013/04 Chemistry in the Treatment of Malaria: From Bench to Bed Seminar
NOVA University, Faculty of Sciences and Technology (Monte da Caparinca, Portugal)
2012/05 Medicinal Chemistry for New Antimalarial Agents ChemForum IST
Instituto Superior Tecnico, Technical University of Lisbon (Lisboa, Portugal)
2012/02 Novel Lead Compounds as Candidates for Single- and Multi-Stage Antimalarial Therapy Seminar
ETH Zurich (Zurich, Suiça)
2011/11 The Pathway From Natural Products to Antimalarials 19th Portuguese-Galician Meeting of Chemistry
Colegio de Quimicos de Galicia and Portuguese Chemical Society (Pontevedra, Espanha)
2011/06 Tuning the Reactivity of the beta-Lactam Scaffold as a Tool To Improve Inhibitory Potency Against Human Neutrophil Elastase 2nd Iberic Meeting on Medicinal Chemistry
(Porto, Portugal)
2011/06 Multi-target Strategies to Treat Malaria: a Challenging Task Seminar
University of Porto, Faculty of Sciences (Porto, Portugal)
2010/10 Rational Design of Bioactive Molecules: From the PC to the Bench and Vice-Versa. Novel Antimalarials Biopharmac 2010
University of Madeira (Funchal, Portugal)
2010/09 From ß-Lactams to 4-Oxo-ß-Lactams: Mechanistic Studies Towards Protease Inhibition 2nd Iberoamerican Symposium on Organic Chemistry (Sibeaqo-II)
(Santiago de Compostela, Espanha)
2010/06 Malaria: the Long Pathway From Concepts to Drugs Seminar
University of Lisbon, Faculty of Sciences (Lisboa, Portugal)
2010/05 Targeting Exoerythrocytic, Erythrocytic and Sexual Stages of Malaria Parasites: a Challenging Task Annual International Conference of Medichem-2010 (ICM-2010)
(Beijing)
2009/06 New strategies in malaria chemotherapy: from recycling antimalarials to structure-base drug design Seminar
University of Evora (Lisboa, Portugal)
2008/12 Design and Synthesis of Human Leukocyte Elastase Inhibitors Based on the ß-Lactam Scaffold Seminar
University of Bonn (Bonn, Alemanha)
2006/12 Perspectivas de Desenvolvimento de Novos Fármacos para a Terapêutica da Malária VI Congresso Luso-Moçambicano de Medicina
2006/02 Recycling Antimalarials New 8-Amino- and 4-Aminoquinoline Analogues GSK Malaria Conference
GlaxoSmithKline (GSK) (Tres Cantos, Madrid, Espanha)
2003/10 Lead Discovery Based on Reactivity Concepts COST Action D13 Conference on New Molecules Towards Human Health Care
COST Action D13 Conference on New Molecules Towards Human Health Care (Li, Portugal)
2003/02 Acyloxymethylation in drug and prodrug design. Scope and limitations Seminar
NOVA University, Faculty of Sciences and Technology (Monte da Caparinca, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2023/03/01 - Atual Discovery of drug leads for SARS-CoV2 by Fragment-Based Drug Design
Coorientador
 Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/01/01 - Atual Novel probes for imaging of tumor-associated cathepsins via Positron Emission Tomography (PET) and fluorescence microscopy
Orientador
 Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/11/01 - Atual New Chemical Tools to Target Necroptosis
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022/11/01 - Atual Synthetic valorization of natural compounds to new derivatives with potential pharmacological activity
Coorientador
 Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2025 Targeting glioblastoma with two-photon-activable triazene prodrugs
Orientador
 Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2025 Extending the Akt-targeting pharmacological toolbox with PROteolysis TArgeting Chimeric molecules (PROTACs)
Orientador
 Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - 2025 Molecular photoswitches for targeting VEGFR2 and control angiogenesis
Orientador
 Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2022 Tetraoxane-based tumor-activated prodrug strategy to target intracellular labile ferrous iron
Orientador
 Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2022 Development of new drug leads for tuberculosis
Coorientador
 Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2022 Expanding the Toolbox of Four-Membered Rings to Study Bacterial Serine Hydrolases
Orientador
 Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2022 Optimizing chemistry in flow with artificial intelligence
Coorientador
 Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2021 Bio-triggered triazenes: a novel approach to release alkylating agents
Orientador
 Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2021 Computational analysis, de novo design, validation and target identification of necroptosis inhibitors
Coorientador
 Medicinal Chemistry (Doutoramento)
Universidade de Coimbra Departamento de Química, Portugal
2016 - 2020 Exploring TOR/PI3K kinases as targets for treating protozoan neglected tropical diseases
Coorientador
 Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2020 Pharmacological Modulators of Parkinson’s Disease-Associated Proteins
Orientador
 Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2020 Discovery of novel quinolone-based antimalarials using the Winterfeldt chemistry
Orientador
 Medicina Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2019 3-Oxo-ß-Sultams and 4-Oxo-ß-Lactams as Chemical Tools for Activity-based Protein Profiling of Serine Hydrolases
Orientador de Luís Carvalho
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012/09/01 - 2017 Medicinal Chemistry Approaches for Novel DNA Ligands
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2016 Medicinal Chemistry Approaches to Malarial Drug Discovery
Coorientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 - 2015 Design and Synthesis of Small Molecule Modulators of p53
Coorientador
 Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2015 Identification and Characterization by Electronspray Mass Spectrometry of Antimalarials that Inhibit the Mitochondrial Electron Transport Chain
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2014 Synthesis and Computer-Assisted Design of Mitochondrial Electron Transport-Chain Inhibitors as Antimalarial Agents
Orientador
 Medicinal Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2010 - 2014 Peroxide-Based Hybrid and Prodrug Antimalarials to Deliver Cysteine Protease Inhibitors Into The Parasitic Food Vacuole
Coorientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2012 Design, Synthesis, and Evaluation of Peptidyl Inhibitors for Clan CA and Clan CD Cysteine Proteases
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2007 - 2011 Compostos híbridos da artemisinina. Direccionamento para as fases sanguínea e hepática do parasita da malária
Coorientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2006 - 2010 Amino Derivatives of Cryptolepine. Synthesis and In Vitro Studies with DNA and Haeme
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2004 - 2010 N-Alkyl-ß-Lactams as Irreversible Inhibitors of Serine Proteases
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2005 - 2009 Irreversible Inhibitors of Serine Proteases Based on the beta-Lactam Scaffold as Potential Drug Candidates
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2003 - 2007 Potential Irreversible Inhibitors of Cysteine Proteases Based on Sultam and Naphthoquinone Scaffolds
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2002 - 2007 Bsmoc Derivatives as Potential Cysteine Protease Inhibitors
Orientador
Universidade de Lisboa Faculdade de Farmácia, Portugal
2001 - 2006 Ensaios de Degradação Acelerada do Nimesulide. 4-Imidazolidinonas Como Possíveis Pró-Fármacos da Primaquina
Orientador
 Pharmaceutical Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
1995 - 2000 Potenciais Pró-Fármacos de Sulfonamidas
Orientador
 Pharmaceutical Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
1992 - 1997 Desenvolvimento de Potenciais Pró-Fármacos de Ácidos Carboxílicos
Orientador
 Pharmaceutical Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
1992 - 1997 Reactividade de Ésteres Carboxamido-, Sulfonamido, e Imidometilicos de Penicilinas
Orientador
 Pharmaceutical Chemistry (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Arbitragem científica em conferência

Nome da conferência Local da conferência
2023/06/10 - 2033/06/13 ACSMEDI-EFMC Medicinal Chemistry Frontiers 2023 American Chemical Society | Division of Medicinal Chemistry
2023/09/03 - 2023/09/07 EFMC-ASMC 2023 IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry European Federation for Medicinal Chemistry
2022/09/04 - 2022/09/09 International Symposium on Medicinal Chemistry EFMC-ISMC 2022 European Federation for Medicinal Chemistry
2016/08/28 - 2016/09/01 International Symposium on Medicinal Chemistry EFMC-ISMC2016 European Federation for Medicinal Chemistry
2013/01 - 2014/09 International Symposium on Medicinal Chemistry EFMC-ISMC2014 European Federation for Medicinal Chemistry
2011/12 - 2012/09 International Symposium on Medicinal Chemistry EFMC-ISMC2012 European Federation for Medicinal Chemistry

Arbitragem científica em revista

Nome da revista (ISSN) Editora
2018 - 2020 MedChemComm (2040-2511) The Royal Society of Chemistry

Membro de associação

Nome da associação Tipo de participação
2008 - Atual American Chemical Society
2000 - Atual Ordem dos Farmacêuticos (Portuguese Board of Pharmacists)
1982/01/18 - Atual Portuguese Chemical Society

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2018/11/01 - Atual Research Foundation Flanders (FWO): chair of the expert panel for pharmaceutical sciences
Outro
 Fonds Wetenschappelijk Onderzoek Vlaanderen, Bélgica
2000 - Atual EMA: Expert in regulatory affairs for drug substances
Outro
 European Medicines Agency, Reino Unido
1998 - Atual INFARMED: Expert in regulatory affairs for drug substances
Outro
 Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
2024/01/01 - 2025/12/31 European Federation for Medicinal Chemistry and Chemical Biology (EFMC): Past-President
Presidente / Vice-presidente
 European Federation for Medicinal Chemistry, Bélgica
2021/01/01 - 2023/12/31 European Federation for Medicinal Chemistry and Chemical Biology (EFMC): President
Presidente / Vice-presidente
 European Federation for Medicinal Chemistry, Bélgica
2020/01/01 - 2020/12/31 European Federation for Medicinal Chemistry (EFMC): President Elect
Presidente / Vice-presidente
 European Federation for Medicinal Chemistry, Bélgica
2016/01/01 - 2019/12/31 European Federation for Medicinal Chemistry (EFMC): member of the Executive Committee
Membro
 European Federation for Medicinal Chemistry, Bélgica
Distinções

Prémio

2009 Luso-American Collaborative Response Awards
Fundação Luso-Americana, Portugal
1985 Sociedade Lusitana Award
Ordem dos Farmaceuticos, Portugal

Título

2015 Honorary Life Fellow, Indian Society of Chemists and Biologists
Indian Society of Chemists and Biologists, Índia

Outra distinção

2014 Chair of the International Simposium on Medicinal Chemistry (EFMC ISMC) 2014