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Inês G. Mollet is a researcher in molecular mechanisms of metabolic and cardiovascular disease, with a degree in Biological Engineering (Université Libre de Bruxelles and Instituto Superior Técnico, Lisbon) and a PhD in Biomedical Sciences from Instituto de Medicina Molecular with Prof. Carmo-Fonseca (Faculdade de Medicina da Universidade de Lisboa, IMM/FMUL) funded by Muscular Dystrophy Association "Profiling alternative splicing in muscular dystrophies" - MDA3662 (2005-2007) and European Alternative Splicing Network of Excellence (2007-2009 EURASNET). Developed during PhD one of the first alternative splicing databases ExonMine to investigate mechanisms of alternative splicing in disease context and published 3 articles. After PhD, worked at Imperial College London (National Heart & Lung Institute, UK) as Research Associate with Dr. Shovlin, maintaining collaborations on gene loci associated with hereditary haemorrhagic telangiectasia using high throughput sequencing publishing 3 articles. During 2010-2016 worked at Lund University Diabetes Centre (Sweden) as Postdoctoral Fellow and Assistant Researcher with Prof. Lena Eliasson (Islet Cell Exocytosis Unit) and Prof. Marju Orho-Melander (Diabetes and Cardiovascular Disease - Genetic Epidemiology Unit), deciphering islet pathophysiology in both rodent models of diabetes and human islets of Langerhans with bioinformatic, wet lab and microscopy involving 17 publications. Collaborated with Dr. Isabel Gonçalves on omics data analysis of human carotid plaques linked to cerebrovascular events that identified tissue and metabolic biomarkers of atherosclerotic plaque vulnerability (5 publications). In 2017 joined NOVA Medical School Research (Lisbon, Portugal) working with Prof. Paula Macedo on effects of plasma exosome derived microRNAs in Metabolic dysfunction-associated fatty liver disease (MAFLD) (1 publication 2021), and with Prof. Helena Vieira on remote ischemic conditioning and plasma proteomics of stroke patients (4 publications). Began independent research in 2017: presented preliminary in-silico analyses, that supported neural involvement in early diabetes aetiology, at the British Society for Neuroendocrinology Gut-brain axis Symposium in Sep 2017 (UK) and was awarded seed funding Project Support Grant (BSN-PSG-2017) to study "Nervous system signalling in the diabetic gut - Links between disrupted nutrient sensing and GABAergic signals". In 2019 set up a Clinical Observational Study (REMIDIA) as principal investigator with surgical team at Digestive Pathology Clinic of Instituto Português de Oncologia FG (IPO-Porto) and NOVA Medical School to investigate novel diabetic targets in human gut biopsies. Since 2021, coordinates proteomics analysis of gut biopsies from bariatric surgery patients in the RESTART Clinical Study coordinated by Prof. Cláudia Marques (FCM|NMS/CINTESIS). In 2021 joined Disease Pathways and Biomarkers research at UCIBIO Applied Molecular Bioscience Unit at FCT-NOVA (Caparica, Portugal) as Senior Researcher. Was awarded funding from Fundação para a Ciência e Tecnologia (DUOBETES - EXPL/MED-PAT/0852/2021) to screen for new high potential therapeutic targets in duodenum against type 2 diabetes". Has supervised 2 Master Theses and taught in curricular units of Masters in Biomedicine (Lund Univ.), PhD Program (NOVA Medical School, Lisbon) and Masters in Biochemistry (FCT-NOVA, Lisbon). In 2023 was awarded six-year individual position funding from Fundação para a Ciência e Tecnologia (2022.03258.CEECIND). Currently researches aetiology of diabetes by investigating early changes in transcriptional and proteomic profiles in the gut of diabetic patients experiencing diabetes remission after metabolic surgery as well as dietary bioactive compounds with therapeutic potential.
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Identification

Personal identification

Full name
Inês Maria de Stoop Camões Teixeira Guerra Mollet

Citation names

  • Mollet, Inês G.

Author identifiers

Ciência ID
1917-E031-10E3
ORCID iD
0000-0002-1422-1336

Email addresses

  • i.mollet@fct.unl.pt (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
English (Mother tongue)
Portuguese (Mother tongue)
French (Mother tongue)
Education
Degree Classification
2012/12/07 - 2012/12/17
Concluded
 Teaching Problem-Based Learning (Pós-doutoramento)
Lunds Universitet, Sweden
2012/11/05 - 2012/11/22
Concluded
 Lecturer Teaching Course - Perspectives on Learning (Lund University) (Pós-doutoramento)
Lunds Universitet, Sweden
2012/06/04
Concluded
 Course for Doctoral Supervisors (Pós-doutoramento)
Lunds Universitet, Sweden
2009/04/14
Concluded
 Biomedical Sciences - Morphological Sciences (Doutoramento)
Instituto de Medicina Molecular, Portugal
"Genome Wide Mining Of Alternative Splicing In Metazoan Model Organisms" (THESIS/DISSERTATION)
 Distinction and honors
2002/01/09
Concluded
 Engenharia Biológica (Mestrado integrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
1994/07/08
Concluded
 Ingenieur Biochimiste (Licence)
Université Libre de Bruxelles, Belgium
"Culture of human and bovine endothelial cells on microspheres in a bioreactor and infection of with the bacteria Cowdria Ruminantium for vaccine production" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2022/01/10 - Current Researcher (Research) Associação para a Inovação e Desenvolvimento da FCT, Portugal
REQUIMTE Unidade de Ciências Biomoleculares Aplicadas, Portugal
2019/08/02 - 2021/07/31 Contracted Researcher (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2016/06/01 - 2019/07/31 Researcher (Research) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2013/02/01 - 2016/04/30 Visiting Researcher (Research) Imperial College London, United Kingdom
2014/03/01 - 2016/03/01 Research Assistant (Research) Lunds Universitet, Sweden
2010/03/01 - 2014/03/01 Postdoc (Research) Lunds Universitet, Sweden
2010/01/01 - 2012/05/01 Visiting Researcher (Research) Imperial College London, United Kingdom
Projects

Grant

Designation Funders
2018/01/01 - Current Nervous system signalling in the diabetic gut - Links between disrupted nutrient sensing and GABAergic signals
93112017 - BSN-PSG-2017
Principal investigator
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 British Society for Neuroendocrinology
Ongoing
2018/10/01 - 2021/09/30 Metabolic chronic diseases stratification: a case for gut-liver axis derived exosomes
PTDC/MEC-MET/29314/2017
Post-doc
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2019/08/02 - 2021/08/01 Remote ischemic post-conditioning in acute phase of ischemic stroke – disclosing novel circulating biomarkers and clinical trial for improving outcome
C493995942-00091545
Research Fellow
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017/02/01 - 2019/06/30 Hepatic inflammation, insulin clearance and hyperinsulinemia: a triad at the basis of prediabetes.
PTDC/BIM-MET/2115/2014
Post-doc Fellow
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2005 - 2007 Profiling alternative splicing in muscular dystrophies"
MDA3662 (2005-2007)

Contract

Designation Funders
2010/03/01 - 2016/02/29 EXODIAB: Excellence in Diabetes Research in Sweden
NA
Post-doc Fellow
Lunds Universitet, Sweden
 Vetenskapsradet
Ongoing
2006/01/01 - 2009/04 European alternative splicing network of excellence
518238
PhD Student Fellow
Instituto de Medicina Molecular, Portugal
 European Commission Sixth Framework Programme
Concluded

Other

Designation Funders
2020/01/23 - 2025/01/23 REMIDIA-1 “Alvos Intestinais Farmacológicos para Induzir Remissão da Diabetes Tipo 2”
no133/2019/CEFCM
Principal investigator
Ongoing
Outputs

Publications

Conference abstract
  1. Mollet IG. "Potencial do bio-marcador sanguíneo miRNA-193b-3p para diagnosticar alterações do metabolismo lipídico na pré-diabetes". Paper presented in 16° Congresso Português de Diabetes (Portuguese Congress on Diabetes), Albufeira, 2020.
  2. Mollet IG. Corresponding author: Mollet IG. "Nervous system signalling in the diabetic gut – Links between disrupted nutrient sensing and neurotrophic and GABAergic signalling in pre-diabetes". Paper presented in British Society for Neuroendocrinology - Annual Meeting, Nottingham, 2017.
  3. Malm HA; Esguerra JLS; Orho-Melander M; Eliasson L; Mollet IG. "Identification of novel targets of the miR-212/132 cluster involved in Wnt-signalling and regulation of insulin secretion in the pancreatic beta cell". Paper presented in European Association for the Study of Diabetes (EASD) Congress - Diabetologia, 2015.
  4. Shovlin CL; Awan I; Naziya AF; Govani FS; Mollet I; Patel D. "P69 One in twenty patients with hereditary hemorrhagic telangiectasia report iron treatments precipitate nosebleeds". Paper presented in 11th International HHT Scientific Conference - Angiogenesis, Florida, 2015.
  5. Malm HA; Berggreen C; Orho-Melander M; Eliasson L; Göransson O; Mollet IG. "Dephosphorylation and nuclear translocation of the CREB-regulated transcription co-activator 1 (CRTC1) elevates miR-212 and miR-132 expression in insulin secreting cells". Paper presented in European Association for the Study of Diabetes (EASD) Congress - Diabetologia, 2014.
  6. Malm HA; Mollet, Inês G; Esguerra JL; Orho-Melander M; Eliasson L. "cAMP mediated regulation of miR-212/132 expression in insulin secreting cells acts through CREB-regulated transcription co-activator 1 (CRTC1)". Paper presented in European Association for the Study of Diabetes (EASD) Congress 2013 - Diabetologia, Barcelona, 2013.
  7. Salunkhe VA; Andersson SA; Esguerra JLS; Mollet IG; Wendt A; Eliasson L. "Regulation of miR-335 expression contributes to orchestrate insulin secretion at the level of exocytosis in insulin secreting INS-1 832/13 cells". Paper presented in European Association for the Study of Diabetes (EASD) Congress 2013 - Diabetologia, Barcelona, 2013.
    https://doi.org/10.1007/s00125-013-3012-z
  8. Hindy G; Mollet IG; Rukh G; Ericson U; Orho-Melander M. "Several type 2 diabetes associated variants in genes involved in WNT- signalling interact with dietary fibre intake on type 2 diabetes incidence". Paper presented in European Association for the Study of Diabetes (EASD) Congress 2013, Barcelona, 2013.
  9. Sharoyko VV; Landin M; Mollet IG; Spégel P; Eliasson L; Wierup N; Mulder H. "Deficiency of TFB1M leads to beta cell dysfunction and development of diabetes". Paper presented in European Association for the Study of Diabetes (EASD) Congress 2012, Diabetologia, 2012.
    https://doi.org/10.1007/s00125-012-2688-9
Conference poster
  1. Mollet, Inês G.; Mira M. "Distinct Disruption of Enteric GABA(B) Receptor Transduction in Type 2 Diabetes and Ageing". Paper presented in Annual British Society for Neuroendoicrinology and the Société de Neuroendcrinologie joint meeting, 2021.
  2. Malm HA; Esguerra JLS; Orho-Melander M; Eliasson L. Corresponding author: Malm HA. "Neuronal Signaling in the Diabetic Gut – Evidence of Enteric Neuro-Endocrine GABAergic Regulation by Subtype-Specific KCTD Auxiliary Subunits". Paper presented in Meeting of the Portuguese Society for Neurosciences SPN2019, 2019.
  3. Mollet, Inês G.. "GABAB Receptors in Subpopulations of Enteric Neuronal and Enteroendocrine Cells in the Proximal Small Intestine are Regulated by Subtype-specific KCTD Auxiliary Subunits". Paper presented in The British Neuroscience Association BNA2019 Festival of Neuroscience, Dublin, Ireland., 2019.
  4. Mollet, Inês G.. "Blood Bio-Marker miR-193b-3p in Pre-Diabetes Regulates Metabolic Disruption through PGC1a, a Master Controler of Glucose and Fatty Acid Metabolism". Paper presented in 15° Congresso Português de Diabetes, Albufeira, Portugal, 2019.
  5. Mollet IG. "Plasma mir-193b-3p could be a biomarker for pre-diabetes progression or regression". Paper presented in 14th Portuguese Congress on Diabetes, 2018.
  6. Mollet IG. "Study of regulation of gene expression by circulating microRNAs (c-miRNAs) previously associated with diabetes and NAFLD reveals convergence of action on insulin regulatory mechanisms and its metabolism". Paper presented in 13th Portuguese Congress on Diabetes, Albufeira, Portugal, 2017.
  7. Eliasson L; Salunkhe VA; Reinbothe T; Mollet IG; Wendt A; Vikman J. "Mice on high fat diet or normal diet have different metabolic responses to rosuvastatin treatment ( Diabetologia 58:S306)". Paper presented in European Association for the Study of Diabetes (EASD) Congress, 2015.
  8. Mollet IG. "CAMTA1 - Calcium-Calmodulin Transcriptional Activator, a new player in the regulation of microRNAs and insulin secretion". Paper presented in European Association for the Study of Diabetes - Islet Study Group Meeting (ISG-EASD), Lausanne)., 2014.
  9. Christensen GL; Jacobsen MLB; Eliasson L; Frederiksen KS; Mollet IG; Friberg J; Bruun C; Billestrup N. "Bone morphogenetic protein 4 inhibits insulin secretion by regulation of Calbindin expression". Paper presented in European Association for the Study of Diabetes -.Islet Study Group Meeting (ISG-EASD), 2013.
  10. Mollet IG; Malm H; Orho-Melander M; Eliasson L. "A calmodulin-binding transcription activator modulates miR-212 and miR-132 expression and insulin secretion in INS-1 832/13 ß-cells". Paper presented in European Association for the Study of Diabetes - Islet Study Group Meeting (ISG-EASD) 2013, Barcelona., 2013.
  11. Salunkhe VA; Braun, M; Esguerra JLS; Mollet, I; Wendt, A; Stoffel, M; Rorsman, P; Eliasson, L. "Influence of miR-375 on electrophysiological properties of voltage-dependent Na+ channels in mouse beta cells". Paper presented in Beta Cell workshop - Programming Beta Cell Development, Impairment and Regeneration, 2011.
  12. Ben-Dov, C; Lozano, JJ; Sammeth, M; Mollet, I; Carmo-Fonseca, M; Valcarcel, J. "Exploring Cellular Codes of Splicing Regulation Using Splicing-Sensitive Microarrays". Paper presented in International Workshop on High Throughput Technologies for Alternative Splicing, 2009.
  13. Mollet, IG; Ben-Dov C; Felício-Silva D; Grosso, AR; Eleutério P; Silva, TS; Carmo-Fonseca, M. ""ExonMine - Unconstrained mining for exons and alternative splicing"". Paper presented in 17th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB) & 8th European Conference on Computational Biology (ECCB), 2009.
  14. Grosso, AR; Mollet, IG; Carmo-Fonseca, M. "Genome-wide bioinformatics search for cancer-associated splicing misregulation". Paper presented in First International EURASNET Conference on Alternative Splicing, 2009.
Journal article
  1. Mollet, Inês; Marto, João Pedro; Mendonça, Marcelo; Baptista, Miguel Viana; Vieira, Helena L. A.. "Remote but not Distant: a Review on Experimental Models and Clinical Trials in Remote Ischemic Conditioning as Potential Therapy in Ischemic Stroke". Molecular Neurobiology (2021): http://dx.doi.org/10.1007/s12035-021-02585-6.
    10.1007/s12035-021-02585-6
  2. Xiao, S; Brown, D; Mollet, IG; Govani, FS; Patel, D; Game, L; Shovlin, CL. "S95 Identifying new hereditary haemorrhagic telangiectasia genes by applying a machine learning approach to screen whole genome sequencing data". Thorax 74 (2019): A59-A60. http://dx.doi.org/10.1136/thorax-2019-BTSabstracts2019.101.
    10.1136/thorax-2019-btsabstracts2019.101
  3. Bernabeu-Herrero M; Patel D; Govan FS; Dibb NJ; Game L; Aldred M; Mollet IG; Shovlin CL. "S94 Identification of natural targets of nonsense-mediated decay relevant to pulmonary vascular diseases". Thorax 74 (2019): A95. http://dx.doi.org/10.1136/thorax-2019-BTSabstracts2019.100.
  4. A. Edlund; M. Barghouth; M. Hühn; M. Abels; J. S.E. Esguerra; Inês Guerra Mollet; E. Svedin; et al. "Defective exocytosis and processing of insulin in a cystic fibrosis mouse model". Journal of Endocrinology 241 1 (2019): 45-57. https://novaresearch.unl.pt/en/publications/78ef9c31-66ba-4976-a0a0-a5f610b78f17.
    10.1530/JOE-18-0570
  5. Tomas, Lukas; Edsfeldt, Andreas; Mollet, Inês G; Perisic Matic, Ljubica; Prehn, Cornelia; Adamski, Jerzy; Paulsson-Berne, Gabrielle; et al. "Altered metabolism distinguishes high-risk from stable carotid atherosclerotic plaques". European Heart Journal 39 24 (2018): 2301-2310. http://dx.doi.org/10.1093/eurheartj/ehy124.
    10.1093/eurheartj/ehy124
  6. Henaoui IS; Jacovetti C; Guerra Mollet I; Guay C; Sobel J; Eliasson L; Regazzi R. "PIWI-interacting RNAs as novel regulators of pancreatic beta cell function.". Diabetologia (2017): http://europepmc.org/abstract/med/28711973.
    10.1007/s00125-017-4368-2
  7. Nicholas LM; Valtat B; Medina A; Andersson L; Abels M; Mollet IG; Jain D; et al. "Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic ß-cells.". Molecular metabolism (2017): http://europepmc.org/abstract/med/28702322.
    10.1016/j.molmet.2017.05.005
  8. Wendt A; Mollet IG; Knutsson A; Bolmgren VS; Hultgårdh-Nilsson A; Gomez MF; Eliasson L. "Osteopontin Affects Insulin Vesicle Localization and Ca2+ Homeostasis in Pancreatic Beta Cells from Female Mice.". PloS one (2017): http://europepmc.org/abstract/med/28107503.
    10.1371/journal.pone.0170498
  9. Ofori JK; Malm HA; Mollet IG; Eliasson L; Esguerra JLS. "Confluence does not affect the expression of miR-375 and its direct targets in rat and human insulin-secreting cell lines.". PeerJ (2017): http://europepmc.org/abstract/med/28674658.
    10.7717/peerj.3503
  10. Kjellqvist S; Klose C; Surma MA; Hindy G; Mollet IG; Johansson A; Chavaux P; et al. "Identification of Shared and Unique Serum Lipid Profiles in Diabetes Mellitus and Myocardial Infarction.". Journal of the American Heart Association (2016): http://europepmc.org/abstract/med/27899364.
    10.1161/JAHA.116.004503
  11. Mollet IG; Malm HA; Wendt A; Orho-Melander M; Eliasson L. "Integrator of Stress Responses Calmodulin Binding Transcription Activator 1 (Camta1) Regulates miR-212/miR-132 Expression and Insulin Secretion". Journal of Biological Chemistry 291 35 (2016): 18440-18452. https://doi.org/10.1074%2Fjbc.m116.716860.
    10.1074/jbc.M116.716860
  12. Salunkhe VA; Mollet IG; Ofori JK; Malm HA; Esguerra JL; Reinbothe TM; Stenkula KG; et al. "Dual Effect of Rosuvastatin on Glucose Homeostasis Through Improved Insulin Sensitivity and Reduced Insulin Secretion.". EBioMedicine (2016): http://europepmc.org/abstract/med/27453321.
    10.1016/j.ebiom.2016.07.007
  13. Edsfeldt A; Dunér P; Ståhlman M; Mollet IG; Asciutto G; Grufman H; Nitulescu M; et al. "Sphingolipids Contribute to Human Atherosclerotic Plaque Inflammation.". (2016): http://europepmc.org/abstract/med/27055903.
    10.1161/ATVBAHA.116.305675
  14. Bennet H; Mollet IG; Balhuizen A; Medina A; Nagorny C; Bagge A; Fadista J; et al. "Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.". (2016): http://europepmc.org/abstract/med/26733006.
    10.1007/s00125-015-3847-6
  15. Malm HA; Mollet IG; Berggreen C; Orho-Melander M; Esguerra JL; Göransson O; Eliasson L. "Transcriptional regulation of the miR-212/miR-132 cluster in insulin-secreting ß-cells by cAMP-regulated transcriptional co-activator 1 and salt-inducible kinases.". (2016): http://europepmc.org/abstract/med/26797246.
    10.1016/j.mce.2016.01.010
  16. Mollet IG; Patel D; Govani FS; Giess A; Paschalaki K; Periyasamy M; Lidington EC; et al. "Low Dose Iron Treatments Induce a DNA Damage Response in Human Endothelial Cells within Minutes.". (2016): http://europepmc.org/abstract/med/26866805.
    10.1371/journal.pone.0147990
  17. Reinbothe TM; Mollet IG. "Optogenetic Control of Pancreatic Islets.". (2016): http://europepmc.org/abstract/med/26965119.
    10.1007/978-1-4939-3512-3_8
  18. Hindy G; Mollet IG; Rukh G; Ericson U; Orho-Melander M. "Several type 2 diabetes-associated variants in genes annotated to WNT signaling interact with dietary fiber in relation to incidence of type 2 diabetes.". Genes & nutrition (2016): http://europepmc.org/abstract/med/27551309.
    10.1186/s12263-016-0524-4
  19. Zaina S; Gonçalves I; Carmona FJ; Gomez A; Heyn H; Mollet IG; Moran S; Varol N; Esteller M. "DNA methylation dynamics in human carotid plaques after cerebrovascular events.". (2015): http://europepmc.org/abstract/med/26088578.
    10.1161/ATVBAHA.115.305630
  20. Tattikota SG; Rathjen T; Hausser J; Khedkar A; Kabra UD; Pandey V; Sury M; et al. "miR-184 Regulates Pancreatic ß-Cell Function According to Glucose Metabolism.". (2015): http://europepmc.org/abstract/med/26152724.
    10.1074/jbc.M115.658625
  21. Christensen GL; Jacobsen ML; Wendt A; Mollet IG; Friberg J; Frederiksen KS; Meyer M; et al. "Bone morphogenetic protein 4 inhibits insulin secretion from rodent beta cells through regulation of calbindin1 expression and reduced voltage-dependent calcium currents.". (2015): http://europepmc.org/abstract/med/25828920.
    10.1007/s00125-015-3568-x
  22. Salunkhe VA; Esguerra JL; Ofori JK; Mollet IG; Braun M; Stoffel M; Wendt A; Eliasson L. "Modulation of microRNA-375 expression alters voltage-gated Na(+) channel properties and exocytosis in insulin-secreting cells.". (2015): http://europepmc.org/abstract/med/25627423.
    10.1111/apha.12460
  23. Shovlin CL; Mollet IG; Giess A; Thomas E; Jones MD; Game L; Govani FS. "P17 Molecular Complexities Identified Through Targeted Genomic Sequencing Of The Hht3 Locus On Chromosome 5". Thorax 69 (2014): A84-A85. http://dx.doi.org/10.1136/thoraxjnl-2014-206260.167.
  24. Sharoyko VV; Abels M; Sun J; Nicholas LM; Mollet IG; Stamenkovic JA; Göhring I; et al. "Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes.". (2014): http://europepmc.org/abstract/med/24916378.
    10.1093/hmg/ddu288
  25. Shovlin CL; Govani FS; Mollet IG; Thomas E; Jones MD; Giess A; Game L. "P14 Very High Quality Next-generation Dna Sequencing Data From Human Genomic Dna Samples Stored, And Intermittently Defrosted Over Two Decades". Thorax 69 (2014): A83. http://dx.doi.org/10.1136/thoraxjnl-2014-206260.164.
  26. Shovlin CL; Patel D; Govani FS; Giess A; Jones MD; Game L; Mollet IG. "P15 Directional Next Generation Whole Transcriptome Sequencing Of Primary Human Pulmonary Microvascular Endothelial Cells". Thorax 69 (2014): A83-A84. http://dx.doi.org/10.1136/thoraxjnl-2014-206260.165.
  27. Fadista J; Vikman P; Laakso EO; Mollet IG; Esguerra JL; Taneera J; Storm P; et al. "Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism.". (2014): http://europepmc.org/abstract/med/25201977.
    10.1073/pnas.1402665111
  28. Edsfeldt A; Gonçalves I; Grufman H; Nitulescu M; Dunér P; Bengtsson E; Mollet IG; et al. "Impaired fibrous repair: a possible contributor to atherosclerotic plaque vulnerability in patients with type II diabetes.". (2014): http://europepmc.org/abstract/med/25035341.
    10.1161/ATVBAHA.114.303414
  29. Esguerra JL; Mollet IG; Salunkhe VA; Wendt A; Eliasson L. "Regulation of Pancreatic Beta Cell Stimulus-Secretion Coupling by microRNAs.". (2014): http://europepmc.org/abstract/med/25383562.
    10.3390/genes5041018
  30. Reinbothe TM; Safi F; Axelsson AS; Mollet IG; Rosengren AH. "Optogenetic control of insulin secretion in intact pancreatic islets with ß-cell-specific expression of Channelrhodopsin-2.". (2014): http://europepmc.org/abstract/med/25483880.
    10.4161/isl.28095
  31. Govani FS; Giess A; Mollet IG; Begbie ME; Jones MD; Game L; Shovlin CL. "Directional next-generation RNA sequencing and examination of premature termination codon mutations in endoglin/hereditary haemorrhagic telangiectasia.". (2013): http://europepmc.org/abstract/med/23801935.
    10.1159/000350208
  32. Mollet IG; Ben-Dov C; Felício-Silva D; Grosso AR; Eleutério P; Alves R; Staller R; Silva TS; Carmo-Fonseca M. "Unconstrained mining of transcript data reveals increased alternative splicing complexity in the human transcriptome.". (2010): http://europepmc.org/abstract/med/20385588.
    10.1093/nar/gkq197
  33. Shovlin CL; Angus G; Manning RA; Okoli GN; Govani FS; Elderfield K; Birdsey GM; et al. "Endothelial cell processing and alternatively spliced transcripts of factor VIII: potential implications for coagulation cascades and pulmonary hypertension.". (2010): http://europepmc.org/abstract/med/20174619.
    10.1371/journal.pone.0009154
  34. Pacheco TR; Coelho MB; Desterro JM; Mollet I; Carmo-Fonseca M. "In vivo requirement of the small subunit of U2AF for recognition of a weak 3' splice site.". (2006): http://europepmc.org/abstract/med/16940179.
    10.1128/MCB.00350-06
  35. Mollet I; Barbosa-Morais NL; Andrade J; Carmo-Fonseca M. "Diversity of human U2AF splicing factors.". (2006): http://europepmc.org/abstract/med/17042780.
    10.1111/j.1742-4658.2006.05502.x
Working paper
  1. Bernabeu-Herrero ME; Patel D; Bielowka A; Srikaran S; Guerrero PC; Govani FS; Mollet IG; et al. 2021. "Heterozygous transcriptional and nonsense decay signatures in blood outgrowth endothelial cells from patients with hereditary haemorrhagic telangiectasia". https://doi.org/10.1101/2021.12.05.471269.
  2. Ana Marta de Jesus Gomes de Matos; Inês de Sousa Lima; Inês Mollet; Maria Teresa Blazquez-Sanchez; Fátima Martins; Maria Joa~o Menezes; Alice Martins; et al. 2018. "Digging into the antidiabetic activity of 8-¿-D-Glucosylgenistein: optimized synthesis, chronic treatment effects in DIO mice, and mechanisms of action". http://hdl.handle.net/10451/42532.

Other

Dataset
  1. Mollet, Inês. ExonMine - Alternative Splicing Database. www.imm.fm.ul.pt/exonmine.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/12/16 Profiling the Humoral Response to Limb Remote Ischemic Conditioning BioSeminars
UCIBIO/FCT-NOVA (Caparica, Portugal)
2020/11/20 Limb Remote Ischemic Conditioning - Blood Profiling in Search of Neuroprotective Signatures Casual Friday with Science
CEDOC - NOVA Medical School (Lisbon, Portugal)
2018/12/14 The role of circulating microRNAs in Metabolic Diseases Casual Friday with Science
CEDOC - NOVA Medical School
2018/11/23 The role of circulating microRNAs in Lipid Metabolism - Implications for Obesity 22° Congresso Portugue^s de Obesidade - Encontro com o Especialista
SPEO - Sociedade Portuguesa para o Estudo da Obesidade (Lisbon, Portugal)
2017/12/06 From Liquid Biopsies to Systems Biomedicine - Tracking networks targeted by circulating microRNAs in metabolic diseases Computational Biology and Bioinformatic Seminars
Instituto de Medicina Molecular (Lisbon, Portugal)
2017/09/12 Nervous system signalling in the diabetic gut – Links between disrupted nutrient sensing and neurotrophic and GABAergic signalling in pre-diabetes Annual Meeting - Gut Brain Axis Symposium
British Society for Neuroendocrinology (Nottingham, United Kingdom)
2017/03/17 "Apresentacao do Estudo Clinico BIOMET – Biomarcadores em exosomas na Remissao da Diabetes Tipo 2 em Cirurgia Metabolica" (Clinical study BIOMET – Exosome Biomarkers of Type 2 Diabetes Remission after Metabolic Surgery) Clinical Meeting - As Espedialidades Aliadas na Cirurgia Baria´trica e Metabo´lica
Serviço Integrado de Cirurgia Bariátrica e Metabólica - British Hospital (Torres de Lisboa) (Lisbon, Portugal)
2015/09/17 CAMTA1 - Calcium-Calmodulin Transcriptional Activator 1, a new player in the regulation of microRNAs and insulin secretion 51st European Association for the Study of Diabetes (EASD) Meeting 2015
EAGE Publications BV (Stockholm, Sweden)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/02/01 - 2022/06/30 Investigating effects of the dietary phytochemical matairesinol on palmitate induced cell damage in a human neural cell line
Supervisor of Raquel Nobrega
 Projecto de Bioquímica (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/02/01 - 2022/06/30 Investigating effects of the dietary phytochemical coumestrol on palmitate induced cell damage in a human neural cell line
Supervisor of Marlon Martins Cavalcante
 Biochemistry Project (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/09/01 - 2021/11/26 Investigating Cellular and Molecular Neuroendocrine Signalling in the Diabetic Gut
Supervisor of Miguel Ângelo de Freitas Mira
 Master in Molecular Genetics and Biomedicine (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2021/02/01 - 2021/07/19 CONDICIONAMENTO ISQUÉMICO REMOTO
Co-supervisor of Catarina Alexandra Morais Fernandes da Costa Bento
 Biochemistry Project (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2020/01/13 - 2020/07/08 Condicionamento isquémico remoto (CIR) em AVC isquémico – avaliação dos mecanismos moleculares e celulares
Co-supervisor of José Maria Fonseca Falcão
Biochemistry Project (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2012/03/01 - 2016/02/29 Transcriptional Regulation of miRNA-212 and miRNA-132 and their fine-tuning function of beta cell insulin secretion
Co-supervisor of Helena Malm
 PhD Biomedical Sciences (PhD)
Lunds Universitet, Sweden

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020/02/29 - 2020/02/29 CEDOC - LYSOCIL 2020 Open Day (2020/02/29 - 2020/02/29)
Festival (Co-organisor)
 Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2018/09/28 - 2018/09/28 European Researchers’ Night - Noite Europeia dos Investigadores (2018/09/28 - 2018/09/28) EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions, Belgium
2016/10/29 - 2016/10/29 CEDOC Open Day (2016/10/29)
Other (Other)
 Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/02/17 - 2022/02/17 Comparative Anatomy and Histology of Laboratory Animals, Rodent Perfusion & Special Procedures
Workshop
 Necropsy Workshop
Instituto Gulbenkian de Ciência, Portugal
2022/01/18 - 2022/01/20 Macro Scripting in ImageJ - COLIfe & FCUL Course
Workshop
 Macro Scripting in ImageJ
2020/02/09 - 2020/02/14 Correlated Multimodal Imaging in Life Sciences, COMULIS - A practical approach to correlative Light and Electron Microscopy
Workshop
 COST Action - COMULIS CLEM Training School
Instituto Gulbenkian de Ciência, Portugal
2018/03/09 - 2018/03/11 Poster - Plasma mir-193b-3p could be a biomarker for pre-diabetes progression or regression
Congress
 14° Congresso Português de Diabetes 2018
Sociedade Portuguesa de Diabetologia, Portugal
2017/03/10 - 2017/03/12 Poster - Study of regulation of gene expression by circulating microRNAs (c-miRNAs) previously associated with diabetes and NAFLD reveals convergence of action on insulin regulatory mechanisms and its metabolism
Congress
 13° Congresso Portugue^s de Diabetes 2017
2015/10/15 - 2015/10/15 Poster - One in twenty patients with hereditary hemorrhagic telangiectasia report iron treatments precipitate nosebleeds
Conference
 11th International HHT Scientific Conference, Oct 2015 Angiogenesis
2015/09/14 - 2015/09/18 Poster - Identification of novel targets of the miR-212/132 cluster involved in Wnt-signalling and regulation of insulin secretion in the pancreatic beta cell
Congress
 European Association for the Study of Diabetes (EASD) Congress 2015
2015/09/14 - 2015/09/18 Poster - Mice on high fat diet or normal diet have different metabolic responses to rosuvastatin treatment
Congress
 European Association for the Study of Diabetes (EASD) Congress 2015
2014/09/19 - 2014/09/21 Poster - CAMTA1 - Calcium-Calmodulin Transcriptional Activator, a new player in the regulation of microRNAs and insulin secretion
Meeting
 European Association for the Study of Diabetes - Islet Study Group Meeting (ISG-EASD) 2014
2014/09/15 - 2014/09/19 Poster - Dephosphorylation and nuclear translocation of the CREB-regulated transcription co-activator 1 (CRTC1) elevates miR-212 and miR-132 expression in insulin secreting cells
Congress
 European Association for the Study of Diabetes (EASD) Congress 2014
2013/09/27 - 2013/09/29 Poster - A calmodulin-binding transcription activator modulates miR-212 and miR-132 expression and insulin secretion in INS-1 832/13 ß-cells
Meeting
 European Association for the Study of Diabetes - Islet Study Group Meeting (ISG-EASD) 2013
2013/09/27 - 2013/09/28 Poster - Bone morphogenetic protein 4 inhibits insulin secretion by regulation of Calbindin expression
Meeting
 European Association for the Study of Diabetes -.Islet Study Group Meeting (ISG-EASD) – 2013
2013/09/23 - 2013/09/27 Poster - cAMP mediated regulation of miR- 212/132 expression in insulin secreting cells acts through CREB-regulated transcription co-activator 1 (CRTC1).
Congress
 European Association for the Study of Diabetes (EASD) Congress 2013
2013/09/23 - 2013/09/27 Poster - Regulation of miR-335 expression contributes to orchestrate insulin secretion at the level of exocytosis in insulin secreting INS- 1 832/13 cells
Congress
 European Association for the Study of Diabetes (EASD) Congress 2013
2013/09/23 - 2013/09/27 Poster - Several type 2 diabetes associated variants in genes involved in WNT- signalling interact with dietary fibre intake on type 2 diabetes incidence
Congress
 European Association for the Study of Diabetes (EASD) Congress 2013
2012/10/01 - 2012/10/05 Poster - Deficiency of TFB1M leads to beta cell dysfunction and development of diabetes
Congress
 European Association for the Study of Diabetes (EASD) Congress 2012
2011/10/23 - 2011/10/26 Poster - Influence of miR-375 on electrophysiological properties of voltage-dependent Na+ channels in mouse beta cells
Meeting
 Beta Cell workshop 2011, “Programming Beta Cell Development, Impairment and Regeneration
2009/06/22 - 2009/07/02 Poster - ExonMine: Unconstrained mining for exons and alternative splicing
Conference
 8th European Conference on Computational Biology (ECCB) 2009
2009/02/05 - 2009/02/07 Poster - Genome-wide bioinformatics search for cancer- associated splicing misregulation
Workshop
 International Workshop on High Throughput Technologies for Alternative Splicing 2009
2009/02/05 - 2009/02/07 Poster - Exploring Cellular Codes of Splicing Regulation Using Splicing-Sensitive Microarrays
Workshop
 International Workshop on High Throughput Technologies for Alternative Splicing 2009

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019/07/17 From a Multitarget Antidiabetic Glycosyl Isoflavone towards New Molecular Entities against Diabetes and Alzheimer’s disease: Generation of Lead Series and Target Assessment
Thesis Member
 Ana Marta de Jesus Gomes de Matos (PhD)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/05/12 - 2021/05/12 Stroke and Vascular dementia PhD Health Sciences - Curricular Unit - Chronic Diseases and Aging Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2014/11/05 - 2014/12/16 Problem Based Learning, Molecular Medicine Module BIMA51 (Faculty of Medicine, Lund University. Molecular Medicine (Bachelor) Lunds Universitet, Sweden

Mentoring / Tutoring

Topic Student name
2018/01/08 - 2018/01/26 Biomedicine PhD Program, Project Development course (NOVA Medical School) Five Students