Olga Sin (541D-01E9-5833)

Curriculum Vitae

Olga Sin

Olga Sin is an alumnus of the GABBA doctoral program (2009) from the University of Porto and has a Ph.D. in neurosciences from the University of Groningen (The Netherlands). Her research focused on finding genetic modifiers of protein aggregation in humanized models of neurodegenerative diseases. During her post-doc at the Max Plack Institute for Molecular Biomedicine (Germany) and University of Bern (Switzerland) she was awarded both the Dutch Rubicon Post-Doctoral Fellowship and the Marie Sklodowska-Curie Individual Fellowship. during this period her research focused on the unexplored relationship between protein aggregation and RNA homeostasis and its impact on neurodegenerative diseases. In 2022, she switched careers to Project Manager of the NCBio ERA Chair project. First, ensures the project’s deliverables are executed and she identifies, prepares and submits applications together with the ERA Chair Holder. Second, she is responsible for establishing relationships with clinicians, health industry and patient groups via the NCBio Stakeholder Hub. Finally, she collaborates with the Communications Unit of the i3S to disseminate neuroscience to the general public.

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Identificação

Identificação pessoal

Nome completo: Olga Sin

Nomes de citação

Sin, Olga
Sin, O

Identificadores de autor

Ciência ID: 541D-01E9-5833
ORCID iD: 0000-0002-0976-0570
Scopus Author Id: 56046384500

Endereços de correio eletrónico

olga.sin@i3s.up.pt (Profissional)

Websites

https://www.i3s.up.pt/personal-info.php?id=3895&idg=201 (Profissional)
https://pt.linkedin.com/in/olga-sin-phd-78bbba137 (Profissional)
https://ncbio.i3s.up.pt/research-team/ (Profissional)

Domínios de atuação

Ciências Médicas e da Saúde - Medicina Básica - Neurociências

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Português (Idioma materno)
Inglês	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)	Utilizador proficiente (C2)
Espanhol; Castelhano	Utilizador elementar (A2)	Utilizador elementar (A2)	Utilizador elementar (A2)	Utilizador elementar (A2)	Utilizador elementar (A2)
Alemão	Utilizador elementar (A1)	Utilizador elementar (A1)	Utilizador elementar (A1)	Utilizador elementar (A1)	Utilizador elementar (A1)

Formação

	Grau	Classificação
2011/11 - 2015/12 Concluído	Graduate Program in Biomedical Sciences (Doctor of Philosophy) Especialização em Neurosciences Rijksuniversiteit Groningen, Países Baixos
2010/01 - 2015/12 Concluído	Programa Doutoral em Biologia Básica e Aplicada (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2007/09 - 2009/07 Concluído	Neurociências (Mestrado integrado) Universidade de Lisboa Faculdade de Medicina, Portugal
2004/09 - 2007/07 Concluído	Biologia Celular e Molecular (Licenciatura) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2022/08 - Atual	Gestão de Ciência e Tecnologia	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

2019/05 - 2022/07	Investigador Contratado (Investigação)	Universität Bern Departement für Chemie und Biochemie, Suiça

2017/05 - 2019/04	Investigador Contratado (Investigação)	Max Planck Institute for Molecular Biomedicine, Alemanha

2011/11 - 2015/12	Investigador Contratado (Investigação)	Rijksuniversiteit Groningen, Países Baixos
	European Research Institute for the Biology of Ageing, Países Baixos

Projetos

Bolsa

	Designação	Financiadores
2017/03 - Atual	Elucidating the role of tRNA processing and modifications in proteostasis. 019.162LW.028	Nederlandse Organisatie voor Wetenschappelijk Onderzoek
2018/09 - 2020/08	The role of tRNA processing and modifications in protein quality control. 746340	European Commission
2010/02 - 2013/07	From phosphorylation to cleavage: switching on alpha-synuclein aggregation and toxicity Provided by PTCRIS: 105215	Fundação para a Ciência e a Tecnologia

Produções

Publicações

Artigo em revista

Esther Stroo; Janssen L.; Olga Sin; Wytse Hogewerf; Mirjam Koster; Liesbeth Harkema; Sameh A Youssef; et al. "Deletion of SERF2 in mice delays embryonic development and alters amyloid deposit structure in the brain". Life Science Alliance (2023): http://dx.doi.org/10.26508/lsa.202201730.
10.26508/lsa.202201730
Sandra Rode; Henrike Ohm; Lea Anhäuser; Marina Wagner; Mechthild Rosing; Xiaobing Deng; Olga Sin; et al. "Differential Requirement for Translation Initiation Factor Pathways during Ecdysone-Dependent Neuronal Remodeling in Drosophila". Cell Reports 24 9 (2018): 2287-2299.e4. https://doi.org/10.1016%2Fj.celrep.2018.07.074.
10.1016/j.celrep.2018.07.074
Francesca Rapino; Sylvain Delaunay; Florian Rambow; Zhaoli Zhou; Lars Tharun; Pascal De Tullio; Olga Sin; et al. "Codon-specific translation reprogramming promotes resistance to targeted therapy". Nature 558 7711 (2018): 605-609. https://doi.org/10.1038%2Fs41586-018-0243-7.
10.1038/s41586-018-0243-7
Olga Sin; Tristan de Jong; Alejandro Mata-Cabana; Michelle Kudron; Mohamad Amr Zaini; Francesco A. Aprile; Renée I. Seinstra; et al. "Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation". Molecular Cell 65 6 (2017): 1096-1108.e6. https://doi.org/10.1016%2Fj.molcel.2017.02.022.
10.1016/j.molcel.2017.02.022
Olga Sin; Ellen A. A. Nollen. "Regulation of protein homeostasis in neurodegenerative diseases: the role of coding and non-coding genes". Cellular and Molecular Life Sciences 72 21 (2015): 4027-4047. https://doi.org/10.1007%2Fs00018-015-1985-0.
10.1007/s00018-015-1985-0
Olga Sin; Helen Michels; Ellen A.A. Nollen. "Genetic screens in Caenorhabditis elegans models for neurodegenerative diseases". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1842 10 (2014): 1951-1959. https://doi.org/10.1016%2Fj.bbadis.2014.01.015.
10.1016/j.bbadis.2014.01.015
"Topic 10. Yeasts as models for ageing & human diseases". Yeast 26 S1 (2009): S176-S195. https://doi.org/10.1002%2Fyea.1693.
10.1002/yea.1693
Fleming-Outeiro Tiago. "Unraveling the role of A-synuclein phosphorylation in the etiology of parkinson's disease". Frontiers in Neuroscience 3 (2009): https://doi.org/10.3389%2Fconf.neuro.01.2009.11.038.
10.3389/conf.neuro.01.2009.11.038

Capítulo de livro

"Analysis of codon-specific translation by ribosome profiling". 191-223. Elsevier, 2021.
10.1016/bs.mie.2021.06.025

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2020	Unraveling the translational landscape of tRNA modification enzyme Mod5	NCCR RNA & Disease Retreat (Kandersteg, Suiça)
2017	Protein aggregation at the Gordon Research Conference: Stress proteins in Growth, Development & Disease	Gordon Research Conference: Stress proteins in Growth, Development & Disease (Lucca, Barga, Itália)
2014	Identification of MOAG-2/LIR-3 as a transcription factor regulating protein aggregation	Dutch Worm Meeting, Groningen (Groningen, Países Baixos)
2014	Identification of MOAG-2/LIR-3 as a transcription factor regulating protein aggregation	Dutch Chaperone Meeting (Groningen, Países Baixos)

Organização de evento

	Nome do evento Tipo de evento (Tipo de participação)	Instituição / Organização
2023/06/30 - 2023/06/30	Neural Cell Biology (NCBio) Stakeholder Hub Kick-Off Meeting (2023/06/30 - 2023/06/30) Conferência (Membro da Comissão Organizadora)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/11/04 - 2022/11/04	Organization of the Meeting of i3S Program of Neurobiology and Neurologic Diseases (2022/11/04 - 2022/11/04) Conferência (Coorganizador)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/10/18 - 2022/10/18	Organization of the VI Portuguese Glia Meeting at the i3S Porto, Portugal (2022/10/18 - 2022/10/18) Conferência (Coorganizador)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013 - 2013	2nd Groningen PhD Day, University of Groningen, (2013 - 2013) Congresso (Membro da Comissão Organizadora)	Rijksuniversiteit Groningen, Países Baixos
2012 - 2012	1st Groningen PhD Day, University of Groningen, The Netherlands (2012 - 2012) Congresso (Membro da Comissão Organizadora)	Rijksuniversiteit Groningen, Países Baixos

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2020 - 2020	Poster Presentation at the Swiss RNA Workshop, Bern, Switzerland Conferência	Swiss RNA Workshop, Bern, Switzerland Universität Bern, Suiça
2019 - 2019	Poster presentation at the Gordon Research Conference: Stress proteins in Growth, Development & Disease Conferência	Gordon Research Conference: Stress proteins in Growth, Development & Disease
2017 - 2017	Poster presentation at the EMBO Workshop on Proteostasis, Ericeira, Portugal Conferência	EMBO Workshop on Proteostasis
2016 - 2016	Poster Presentation at the RNA Biochemistry Meeting, Bonn, Germany Conferência	RNA Biochemistry Meeting
2015 - 2015	Poster presentation at the 1st Molecular Biology of Ageing Meeting, Groningen, The Netherlands Conferência	1st Molecular Biology of Ageing Meeting European Research Institute for the Biology of Ageing, Países Baixos
2015 - 2015	Poster presentation at the 20th International C. elegans Meeting, Los Angeles, USA Conferência	The 20th International C. elegans Meeting Cold Spring Harbor Laboratory, Estados Unidos
2014 - 2014	Poster presentation at the European Worm Meeting, Berlin, Germany Conferência	European Worm Meeting, Berlin, Germany
2011 - 2011	Poster presentation at the 1st Dutch Huntington Symposium, Groningen, The Netherlands Conferência	1st Dutch Huntington Symposium, Groningen, The Netherlands
2010 - 2010	Poster presentation at the Gordon Research Conference: CAG Triplet Repeat Disorders, Lucca, Italy Conferência	Gordon Research Conference: CAG Triplet Repeat Disorders, Lucca, Italy
2009 - 2009	Poster presentation at the 11th Meeting of the Portuguese Society for Neurosciences, Braga, Portugal Conferência	11th Meeting of the Portuguese Society for Neurosciences, Braga, Portugal

Curso / Disciplina lecionado

	Disciplina	Curso (Tipo)	Instituição / Organização
2020 - 2021	Biochemistry I practical course for B.Sc. Biology, Chemistry and Biochemistry	B.Sc. Biology, Chemistry and Biochemistry (Bachelor)	Universität Bern, Suiça
2017 - 2017	Model Systems in Biomedical Research	(Master)	Universitätsklinikum Münster, Alemanha
2015 - 2016	Human Genetics	Human Genetics (Doutoramento)	Universidade do Porto, Portugal
2014 - 2014	Molecular Mechanisms of Ageing	2nd COST Summer School (Bachelor)	Rijksuniversiteit Groningen, Países Baixos
2013 - 2014	C. elegans as a model organism	Genes and Behavior (Bachelor)	Rijksuniversiteit Groningen, Países Baixos
2011 - 2014	C. elegans as a model organism	Topmaster Medical and Pharmaceutical Drug Innovation program	Rijksuniversiteit Groningen, Países Baixos

Entrevista (jornal / revista)

	Descrição da atividade	Jornal / Forum
2017/05/17	Famelab Germany Final, Bielefeld, Germany	Macau Daily Times
2017/04/28	FameLab Germany final, Bielefeld, Germany	Westfalen Blatt
2017/03/24	FameLab Germany regional heat, Bielefeld, Germany	Westfalen Blatt

Outro júri / avaliação

	Descrição da atividade	Instituição / Organização
2017 - 2022	MINT-EC SchoolSlam (network of STEM schools)	British Council Germany, Alemanha

Distinções

Prémio

2020	COMET Career-building program for Excellent Female Postdocs of the University of Bern Universität Bern, Suiça
2019	Max Gruber Prize for best peer reviewed publication in Biochemistry or Cell Biology Rijksuniversiteit Groningen, Países Baixos
2017	Rubicon Postdoctoral Fellowship Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Países Baixos
2017	Marie Sklodowska-Curie Postdoctoral Fellowship European Commission, Bélgica
2016	Cells-in-Motion Pilot Project Max-Planck-Institut für molekulare Biomedizin, Alemanha
2016	Selected participant for the Sign Up! Career-building Program for Excellent Female Postdocs of the Max Planck Society Max-Planck-Institut für molekulare Biomedizin, Alemanha
2015	Simonsfonds travel grant Simons Foundation, Estados Unidos
2010	PhD Fellowship from the Graduate Program in Areas of Basic and Applied Biology Universidade do Porto, Portugal
2009	PhD Fellowship Fundação para a Ciência e a Tecnologia, Portugal

Outra distinção

2018	Selected young researcher for participation at the 68th Lindau Nobel Laureate Meeting