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Dr. Cristiana de Carvalho has finished her master degree in Pharmaceutical Sciences in 2012 through the faculty of Pharmacy of University of Porto with the GPA of 15 (in 20). She later concluded her PhD degree in Tissue Engineering, Regenerative Medicine and Stem Cells in 3Bs Research group, in 2019/10/11, in Neurosciences, namely in peripheral nerve regeneration, with the highest qualitative grade "Menção honrosa de Muito Bom". Dr. Cristiana was immediately awarded with a postdoctoral fellowship under the project 2IQBIONEURO, which articulates a network of R&D in biological chemistry for the treatment of neurological diseases, specifically continuing her research path of neuronal research. During her PhD, she was a visiting/invited researcher at Neuroanatomy department in Hannover Medical School (Germany) and later at New Jersey Center for Biomaterials at Rutgers University. Furthermore, to be able to carry a secondment as invited/visiting researcher in the USA New Jersey Center for Biomaterials, she was awarded a full financial grant by FLAD. In the scope of her PhD, Dr. Cristiana published 7 manuscripts in specialized peer-reviewed journals as first author, 1 manuscript as co-author, 1 book chapter and is the author of 2 filled patents. Over the last 7 years as a researcher or a PhD candidate, Cristiana helped in the writing and actively participated in 6 different FCT or CE funded projects. She is now specialized in Biomaterials, Biomaterials characterization, nerve regeneration, growth factors, Tissue engineering and nerve guidance conduits. Overall, her good and impactful scientific work led to more than 20 participations in national and international conferences. Furthermore, she was also an invited speaker at the European Arthroscopy fellowship 2019/SPAT-ESSKA in 2019 at 3Bs research group.
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Identificação

Identificação pessoal

Nome completo
Cristiana de Carvalho

Nomes de citação

  • Carvalho, Cristiana
  • Carvalho, C. R.

Identificadores de autor

Ciência ID
031E-D08A-0F63
ORCID iD
0000-0001-9215-280X

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Francês Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A1)
Formação
Grau Classificação
2015/02/01 - 2019/10/11
Concluído
 Tissue Engineering, Regenerative Medicine and Stem cells (Doutoramento)
Especialização em Peripheral Nerve Regeneration
Universidade do Minho, Portugal
"Combinatorial Approaches for the Development of Conduits for Guided Peripheral Nerve Regeneration" (TESE/DISSERTAÇÃO)
 Muito Bom
2007/09/15 - 2012
Concluído
 Integrated Master in Pharmaceutical Sciences (Mestrado integrado)
Universidade do Porto Faculdade de Farmácia, Portugal
"Síndrome do Cólon Irritável - Um problema de sáude pública" (TESE/DISSERTAÇÃO)
 15
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2020/01/06 - Atual Pós-doutorado (Investigação) Universidade do Minho, Portugal
3Bs Research Group, Universidade do Minho, Portugal
2015/01 - 2019/11 Investigador (Investigação) 3Bs Research Group, Universidade do Minho, Portugal
3Bs Research Group, Universidade do Minho, Portugal
2018/01 - 2018/09 Investigador visitante (Investigação) New Jersey Center for Biomaterials, Estados Unidos
New Jersey Center for Biomaterials, Estados Unidos
2014/05 - 2014/11 Investigador visitante (Investigação) Medizinische Hochschule Hannover, Alemanha
Medizinische Hochschule Hannover, Alemanha
2010/09/01 - 2010/10/30 Estagiário de Investigação (Investigação) 3Bs Research Group, Universidade do Minho, Portugal
3Bs Research Group, Universidade do Minho, Portugal
Projetos

Bolsa

Designação Financiadores
2019/01/01 - 2021/12/29 NanOptoNerv - Nano-accelerated nerve regeneration and optogenetic empowering of neuromuscular functionality
PTDC/NAN-MAT/29936/2017
Investigador
3Bs Research Group, Universidade do Minho, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Em curso
2016/09/01 - 2019/11/11 UMINHO/BD/7/2016 - PhD scholarship Norte2020
UMINHO/BD/7/2016
Bolseiro de Doutoramento
3Bs Research Group, Universidade do Minho, Portugal
 Norte2020
Concluído
2018/02/01 - 2018/09/29 FLAD scholarship (Proj. 29/2018)
Proj 29/2018
Investigador
Fundação Luso-Americana para o Desenvolvimento, Portugal
2018/03 - 2018/09 FROnTHERA - Frontiers of technology for theranostics of cancer, metabolic and neurodegenerative diseases
NORTE-01-0145-FEDER-000023
Investigador
3Bs Research Group, Universidade do Minho, Portugal
Em curso
2017/03 - 2018/05 ComplexiTE - An integrated multidisciplinary tissue engineering approach combining novel high-throughput screening and advanced methodologies to create complex biomaterials-stem cells constructs
321266
Investigador
3Bs Research Group, Universidade do Minho, Portugal
 Comissão Europeia
Concluído
2014 - 2015 POLARIS - Unlocking the research potential of 3Bs Group, University of Minho, in Nanomedicine field to strengthen its competitive position at the European level
316331
Investigador
3Bs Research Group, Universidade do Minho, Portugal
 Comissão Europeia
Concluído

Projeto

Designação Financiadores
2020/01 - Atual 2IQBIONEURO
0624_2IQBIONEURO_6_E
Bolseiro de Pós-Doutoramento
CiQUS - Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares, Espanha
 Interreg
2020/01 - Atual 2IQBIONEURO
0624_2IQBIONEURO_6_E
 Interreg
2016/03 - 2017/06 IF/01285/2015 - Advancing Precision Medicine through the Development of In Vitro Tissue Engineered 3D Tumour Models and Multi-omics
IF/01285/2015
Investigador
3Bs Research Group, Universidade do Minho, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Em curso
Produções

Publicações

Artigo em revista
  1. Carvalho, Cristiana; Oliveira, Joaquim Miguel; Reis, Rui L.. "Modern Trends for Peripheral Nerve Repair and Regeneration: Beyond the Hollow Nerve Guidance Conduit". Frontiers in Bioengineering and Biotechnology 7 (2019): http://dx.doi.org/10.3389/fbioe.2019.00337.
    Publicado • 10.3389/fbioe.2019.00337
  2. Carvalho, Mariana R.; Carvalho, Cristiana; Maia, F. Raquel; Caballero, David; Kundu, Subhas C.; Reis, Rui L.; Oliveira, Joaquim Miguel. "Peptide-Modified Dendrimer Nanoparticles for Targeted Therapy of Colorectal Cancer". Advanced Therapeutics 2 11 (2019): 1900132. http://dx.doi.org/10.1002/adtp.201900132.
  3. Carvalho, Cristiana; Silva-Correia, Joana; Oliveira, Joaquim Miguel; Reis, Rui L.. "Nanotechnology in peripheral nerve repair and reconstruction". Advanced Drug Delivery Reviews 148 (2019): 308-343. http://dx.doi.org/10.1016/j.addr.2019.01.006.
    Publicado • 10.1016/j.addr.2019.01.006
  4. Carvalho, Cristiana; Costa, J. B.; Costa, Lígia; Silva-Correia, Joana; Moay, Zi Kuang; Ng, Kee Woei; Reis, Rui L.; Oliveira, Joaquim Miguel. "Enhanced performance of chitosan/keratin membranes with potential application in peripheral nerve repair". Biomaterials Science 7 12 (2019): 5451-5466. http://dx.doi.org/10.1039/c9bm01098j.
    Publicado • 10.1039/c9bm01098j
  5. Carvalho, Cristiana; Costa, J. B.; da Silva Morais, Alain; López-Cebral, Rita; Silva-Correia, Joana; Reis, Rui L.; Oliveira, Joaquim Miguel. "Tunable Enzymatically Cross-Linked Silk Fibroin Tubular Conduits for Guided Tissue Regeneration". Advanced Healthcare Materials 7 17 (2018): 1800186. http://dx.doi.org/10.1002/adhm.201800186.
    10.1002/adhm.201800186
  6. Carvalho, Cristiana; Wrobel, S.; Meyer, C.; Brandenberger, C.; Cengiz, I. F.; López-Cebral, R.; Silva-Correia, Joana; et al. "Gellan Gum-based luminal fillers for peripheral nerve regeneration: an in vivo study in the rat sciatic nerve repair model". Biomaterials Science 6 5 (2018): 1059-1075. http://dx.doi.org/10.1039/c7bm01101f.
    10.1039/c7bm01101f
  7. Carvalho, Cristiana; López-Cebral, Rita; Silva-Correia, Joana; Silva, Joana M.; Mano, João F.; Silva, Tiago H.; Freier, Thomas; Reis, Rui; Oliveira, Joaquim Miguel. "Investigation of cell adhesion in chitosan membranes for peripheral nerve regeneration". Materials Science and Engineering: C 71 (2017): 1122-1134. http://dx.doi.org/10.1016/j.msec.2016.11.100.
    Publicado • 10.1016/j.msec.2016.11.100
Capítulo de livro
  1. Carvalho, Cristiana; Reis, Rui L.; Oliveira, Joaquim Miguel. "Fundamentals and current strategies for peripheral nerve regeneration and repair". In Advances in Experimental Medicine and Biology (AEMB), editado por Heung Jae Chun; Antonella Motta; Rui L. Reis; Gilson Khang. Singapura: Springer Nature Singapore, 2020.
    Aceite para publicação
Poster em conferência
  1. Carvalho, Cristiana; Oliveira, Joaquim Miguel; Reis, Rui. "Current tendencies for peripheral nerve repair and regeneration: What comes after the hollow nerve guidance conduit?". Trabalho apresentado em 1st Discoveries Forum on Regenerative and Precision Medicine, 2019.
  2. Carvalho, C. R.; Oliveira, Joaquim Miguel; Reis, Rui L.. "Neurotrophic Factor Delivery by an Engineered Silk-based Nerve Conduit for Peripheral Nerve Repair". Trabalho apresentado em 1st Discoveries Forum on Regenerative and Precision Medicine, 2019.
  3. Carvalho, C. R.; Escobar, Ane; Reis, Rui; Oliveira, Joaquim Miguel. "Nanoparticles for growth factor delivery in nerve guidance conduits: An Overview". Trabalho apresentado em TermStem, 2019.
  4. Carvalho, C. R.; Escobar, Ane; Reis, Rui; Oliveira, Joaquim Miguel. "Promotion of peripheral nerve regeneration with optogenetic neuromuscular stimulation". Trabalho apresentado em ForeCast, 2019.
  5. Carvalho, Cristiana; Oliveira, Joaquim Miguel; Reis, Rui. "Development and application of new keratin/chitosan biomaterials for Peripheral Nerve Regeneration". Trabalho apresentado em Chem2Nature, 2018.
    10.1115/sbc2010-19680
  6. Carvalho, Cristiana; Oliveira, Joaquim Miguel; Reis, Rui. "In vitro and In vivo Evaluation of Different Gellan Gum Formulations for Peripheral Nerve Regeneration". Trabalho apresentado em SFB, Society for Biomaterials, 2017.
  7. Carvalho, Cristiana; Oliveira, Joaquim Miguel; Reis, Rui. "Gellan Gum as a new biomaterial for peripheral nerve regeneration". Trabalho apresentado em Forecast, 2017.
  8. Carvalho, Cristiana; Reis, Rui; Silva-Correia, Joana; Oliveira, Joaquim Miguel. "Gellan Gum for Peripheral Nerve Regeneration applications: In vitro and in vivo evaluation". Trabalho apresentado em Chem2Nature, 2017.
    10.1109/ner.2013.6695919
  9. Carvalho, C. R.; Reis, Rui; Oliveira, Joaquim Miguel. "Application of new keratin/chitosan biomaterials for Peripheral Nerve Regeneration". Trabalho apresentado em FBPS, 2017.
  10. Carvalho, Cristiana; Reis, Rui; Oliveira, Joaquim Miguel. "Chitosan films with varying degrees of acetylation for application in peripheral nerve regeneration". Trabalho apresentado em WBC, World Biomaterials Congress, 2016.
  11. Carvalho, C. R.; Oliveira, Joaquim Miguel; Reis, Rui. "Chitosan films with varying degrees of acetylation for application in peripheral nerve regeneration". Trabalho apresentado em TermStem, 2016.
  12. Carvalho, Cristiana; Oliveira, Joaquim Miguel; Reis, Rui. "Chitosan nanofibers for peripheral nerve applications". Trabalho apresentado em ESB, European Society for Biomaterials, 2015.
  13. Carvalho, C. R.; Oliveira, Joaquim Miguel; Reis, Rui. "Chitosan Films with Low Degrees of Acetylation for Peripheral Nerve Regeneration". Trabalho apresentado em FBPS, 2015.
  14. Carvalho, Cristiana; Oliveira, Joaquim Miguel; Reis, Rui. "Keratin/chitosan as novel grafts for peripheral nerve regeneration". Trabalho apresentado em TermStem, 2014.
    10.1002/term.1932
  15. Carvalho, C. R.; Reis, Rui; Oliveira, Joaquim Miguel. "Keratin/chitosan as novel grafts for peripheral nerve regeneration". Trabalho apresentado em TERMIS EU, 2014.
  16. Carvalho, Cristiana; Oliveira, Joaquim Miguel; Reis, Rui. "Chitosan nanofibers as scaffolds for peripheral nerve regeneration". Trabalho apresentado em TermStem, 2013.
    10.1002/term.1822
Tese / Dissertação
  1. Carvalho, C. R.. "Combinatorial approaches for the development of conduits for guided peripheral nerve regeneration". Doutoramento, 3Bs Research Group, Universidade do Minho, 2019.

Propriedade Intelectual

Patente
  1. Carvalho, Cristiana; Costa, J. B.; Silva-Correia, Joana; Reis, Rui L.; Oliveira, Joaquim Miguel. 2018. "Nerve guidance conduits derived from silk fibroin hydrogels: methods of production and uses thereof". Portugal.
    Concedida/Emitida
Pedido provisório de patente
  1. 2019. "Implantable silk hydrogel microfluidic platform, methods of production and uses thereof".
    Protegido
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2020/04/04 Biomaterials for the Development of Conduits for Guided Peripheral Nerve Regeneration XI Symposium on Bioengineering
NEB-FEUP/ICBAS (Porto, Portugal)
2019 Delivery of Neurotrophic factors in a Silk-based Nerve Conduit for Peripheral Nerve Repair Society for Biomaterials Annual Meeting
(Seattle, Estados Unidos)
2019 Neurotrophic Factor Loaded in Enzymatically-Crosslinked Silk Fibroin Conduits for Peripheral Nerve Regeneration TERMIS European Meeting
(Rodes, Grécia)
2019 Biomaterials for the Development of Conduits for Guided Peripheral Nerve Regeneration European arthroscopy fellowship 2019 SPAT/ESKKA
3Bs research Group (Guimarães, Portugal)
2015 Chitosan Films with Low Degrees of Acetylation for Peripheral Nerve Regeneration 11th Frontiers in Biomedical Polymers Symposium
(Itália)
2014 Chitosan nanofibers for guided peripheral nerve regeneration 2nd International Symposium on Peripheral Nerve Regeneration
(Itália)

Tutoria

Tópico Nome do aluno
2019/09 - 2019/10 Silk Fibroin conduits production Ane Escobar
2016/03 - 2016/09 Chitosan nanofibers fabrication Rita López-Cebral
2014/09 - 2015/02 Production and characterization of chitosan/keratin blends José Pedro Gonçalves
Distinções

Prémio

2020 Julia Polak European Doctorate Award
European Society of Biomaterials, França

Outra distinção

2018 Awarded FLAD Scholarship (Proj. 29/2018)
Fundação Luso-Americana para o Desenvolvimento, Portugal