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Carolina Ferreira is currently a PhD student enrolled at the Health Sciences Program from the Faculty of Medicine of the University of Coimbra, in the Institute of Pharmacology and Experimental Therapeutics , after being awarded a FCT PhD grant (2021.05312.BD) with the project "Blueberry leaf biomass: a nutraceutical for Multiple Sclerosis’ relief by targeting the gut-immune-CNS axis", under the supervision of Flávio Reis, Sofia Viana and Miguel Castelo-Branco. Previously, in the same Faculty she concluded a Master's degree in Biomedical Research, in the branch of Neurosciences, preceded by a Bachelor's degree in Biochemistry from the University of Coimbra. Her master thesis entitled "Preclinical evaluation of the therapeutic potential of Vaccinium corymbosum L. (blueberry) leaf biomass in experimental Multiple Sclerosis" was developed at the Coimbra Institute for Clinical and Biomedical Research (iCBR) - Faculty of Medicine from Coimbra University (FMUC). Both degrees have provided her with solid knowledge in animal experimentation, molecular and biological sciences supported by the practice of distinct techniques such as PCR, Western Blot, and microscopy, among others. Being part of the research group "Insulin Resistance and Diabetic Angiopathy", coordinated by Flávio Reis, she developed research work related to therapeutic and nutraceutical approaches in the prevention and/or treatment of neurodegenerative disorders, using animal models of cuprizone-induced demyelination. She has been involved in several preclinical research projects, such as "FRUTIFY: Use of blueberry juice as a nutraceutical strategy targeting gut dysbiosis to prevent the progression from prediabetes to diabetes" [PTDC/SAU-NUT/31712/2017], funded by the Foundation for Science and Technology (FCT), and "Remielinization promoting strategies for an animal model of Multiple Sclerosis" [INOVC2020-SAAC-CENTRO-46-2016-01-5625], funded by INOVC 2020. During her research carrier, she had the opportunity to author three review-papers published in international peer-reviewed journals. Furthermore, Carolina has been an active communicator of her research outputs by participating in several national meetings resulting in 4 oral communications as first author. Alongside her research activity, Carolina actively contributed to the laboratory training of undergraduate and graduate students. Likewise,she participates in a project under a confidentiality agreement, related with the development of a "Semi-solidformulation for voluntary oral administration of bioactive compounds in rodents", which is currently under an International Patent Application (no PCT/IB2021/053124). In 2020, she attained Functions A+B for manipulation and design of animal experimental protocols, certified by DGAV, the National Authority for Regulation of Animal Research. Carolina was also involved in an awarded distinction with the 1st Place in the Sustainable Campus Network competition - "From linear to circular ideas".
Identificação

Identificação pessoal

Nome completo
Ana Carolina Marques Ferreira

Nomes de citação

  • Ferreira, Carolina

Identificadores de autor

Ciência ID
0E14-4554-7C81
ORCID iD
0000-0002-4074-9513

Endereços de correio eletrónico

  • f202carolina@gmail.com (Profissional)

Moradas

  • iCBR / FMUC, Polo III - Health Sciences Campus - Azinhaga Santa Comba, Celas, 3000-548, Coimbra, Celas, Portugal (Pessoal)

Domínios de atuação

  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Médicas e da Saúde - Ciências da Saúde

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Português (Idioma materno)
Inglês Utilizador independente (B2) Utilizador proficiente (C2) Utilizador independente (B2) Utilizador proficiente (C2) Utilizador independente (B2)
Espanhol; Castelhano Utilizador elementar (A1) Utilizador independente (B1) Utilizador elementar (A1) Utilizador elementar (A2) Utilizador elementar (A1)
Formação
Grau Classificação
2023/05/29 - 2023/06/09
Concluído
Advanced Imaging Methods in Neuroscience (Curso médio)
Especialização em Imagiologia em Neurociência
Universidade de Coimbra, Portugal

Universidad de Salamanca, Espanha
2023/04/27 - 2023/06/02
Concluído
Online Advanced Course on Biomedical Imaging 2023 (Curso médio)
Especialização em Imagiologia Biomédica
Universidade de Coimbra, Portugal

The University of Texas at Austin UT Health Austin, Estados Unidos
2023/03/07 - 2023/03/08
Concluído
Flow Cytometry and Cell Sorting - From Basic Concepts to Artificial Intelligence applied to Data Analysis (Curso médio)
Especialização em Flow Cytometry
Universidade de Coimbra, Portugal
2023/01/23 - 2023/01/27
Concluído
Business Ignition Program in Ageing (Curso médio)
Universidade de Coimbra, Portugal

Instituto Pedro Nunes, Portugal
2022/07/05 - 2022/07/07
Concluído
Competency Based Skills Training in Mice and Rats (Curso médio)
CNC.IBILI, Portugal
2022/03/11 - 2022/06/03
Concluído
Online Advanced Course on Biomedical Imaging 2022 (Curso médio)
Especialização em Imagiologia Biomédica
The University of Texas at Austin UT Health Austin, Estados Unidos
2020/09/16 - 2021/10/05
Concluído
Masters in Biomedical Research (Mestrado)
Especialização em Neurosciences
Universidade de Coimbra Faculdade de Medicina, Portugal
"Preclinical evaluation of the therapeutic potential of Vaccinium corymbosum L.(blueberry) leaf biomass in experimental Multiple Sclerosis" (TESE/DISSERTAÇÃO)
18
2020/11/09 - 2020/11/20
Concluído
IV Modular Training in Laboratory Animal Course - Function B (Curso médio)
Especialização em Designing procedures and projects
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
17
2020/11/09 - 2020/11/20
Concluído
IV Modular Training in Laboratory Animal Course - Function A (Curso médio)
Especialização em Carrying out procedures on animals
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
17,75
2020/03 - 2020/03
Concluído
Fluorescence and Confocal Microscopy training (Curso médio)
CNC.IBILI, Portugal
2016/09/18 - 2019/07/20
Concluído
Biochemistry (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"The role of anthocyanins from portuguese blueberries in Autism Spectrum Disorder" (TESE/DISSERTAÇÃO)
16,4
Projetos

Projeto

Designação Financiadores
2020/06 - Atual NephroCardio Risk - Reliable biomarkers of chronic kidney disease and of the associated cardiovascular risk. Construction of (bio)sensors for the selected biomarkers
Norte-01-0145-FEDER-000024
Animal care
Universidade do Porto Faculdade de Farmácia, Portugal

Centro Hospitalar Universitário do Porto EPE, Portugal
European Regional Development Fund
Em curso
2020 - Atual FRUITIFY - Use of blueberry juice as a nutraceutical strategy targeting gut dysbiosis to prevent the progression from prediabetes to diabetes
PTDC/SAU-NUT/31712/2017
POCI-01-0145-FEDER-031712
PTDC/SAU-NUT/31712/2017
Animal care
CNC.IBILI, Portugal

Universidade de Coimbra Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Em curso
2020 - Atual INOVC2020 - IGNITION GRANT - The therapeutic potential of Vaccinium corymbosum L. senescent leaves (blueberries) in Multiple Sclerosis: adding value to a regional agro-waste product.
INOVC2020-SAAC-CENTRO-46-2016-01-5625
Colaboradora
Universidade de Coimbra Faculdade de Medicina, Portugal
European Regional Development Fund
Em curso
Produções

Publicações

Artigo em revista
  1. Ferreira, Carolina; Vieira, Pedro; Sá, Helena; Malva, João; Castelo-Branco, Miguel; Reis, Flávio; Viana, Sofia. "Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases". Frontiers in Immunology 15 (2024): http://dx.doi.org/10.3389/fimmu.2024.1360065.
    Publicado • 10.3389/fimmu.2024.1360065
  2. Ferreira, Carolina; Pedro Vieira; Helena Sá; João O. Malva; Castelo-Branco, Miguel; Flávio Reis; Sofia Viana. "Polyphenols: Immunonutrients Tipping the Balance of Immunometabolism in Chronic Disease". Frontiers in Immunology (2024):
    Submetido
  3. Ferreira, Carolina; Viana, Sofia D.; Reis, Flávio. "Is Gut Microbiota Dysbiosis a Predictor of Increased Susceptibility to Poor Outcome of COVID-19 Patients? An Update". Microorganisms 9 1 (2020): 53. http://dx.doi.org/10.3390/microorganisms9010053.
    Publicado • 10.3390/microorganisms9010053
  4. Ferreira, Carolina; Viana, Sofia D.; Reis, Flávio. "Gut Microbiota Dysbiosis–Immune Hyperresponse–Inflammation Triad in Coronavirus Disease 2019 (COVID-19): Impact of Pharmacological and Nutraceutical Approaches". Microorganisms 8 10 (2020): 1514. http://dx.doi.org/10.3390/microorganisms8101514.
    Publicado • 10.3390/microorganisms8101514
Poster em conferência
  1. Pedro Vieira; Nunes, Sara; Preguiça, Inês; Ferreira, Carolina; Alves, André; Almeida, Jani; Vera Alves. ""Imunomodulação intestinal e benefícios metabólicos de uma fibra prebiótica proveniente de desperdícios agrícolas do mirtilo: ensaio em modelo animal de diabetes mellitus tipo 2".". Trabalho apresentado em 19º Congresso Português de Diabetes, 2023., 2023.
  2. Alves, André; Pedro Vieira; Preguiça, Inês; Ferreira, Carolina; Sara Nunes; Pedro Gomes; Solange Semião. ""Efeito de dietas refinadas na indução de doença metabólica em rato – destaque para o impacto na microbiota intestinal e na função renal".". Trabalho apresentado em 19º Congresso Português de Diabetes, 2023., 2023.
  3. Flávio Reis; Preguiça, Inês; Pedro Vieira; Ferreira, Carolina; Alves, André; Sara Nunes; Mónica Zuzarte. ""Upcycling berries' agrowaste into sustainable prebiotics favoring gut mucosal immunity: the case of senescent bluberry leaf".". Trabalho apresentado em 3rd International World of Microbiome Conference, 2022., 2022.
Resumo em conferência
  1. Pedro Vieira; Nunes, Sara; Preguiça, Inês; Ferreira, Carolina; Alves, André; Almeida, Jani Sofia; Helena Sá; et al. "P054 Imunomodulação intestinal e benefícios metabólicos de uma fibra prebiótica proveniente de desperdícios agrícolas do mirtilo: ensaio em modelo animal de diabetes mellitus tipo 2.". Trabalho apresentado em 19º Congresso Português de Diabetes, 2023., Algarve, 2023.

Propriedade Intelectual

Patente
  1. Flávio Reis; Sofia Viana. 2021. ""Semi-Solid Formulation for Voluntary Oral Administration of Bioactive Compounds to Rodents".".
    Permitida
Pedido provisório de patente
  1. 2020. ""Semi-Solid Formulation for Voluntary Oral Administration of Bioactive Compounds to Rodents- Pedido provisório de patente no 116301".".
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2024/02/09 (De/Re)myelination dynamics in cuprizone-induced multiple sclerosis: focus on the gut-neuroimmune axis 54th Meeting of the Portuguese Society of Pharmacology, 42nd Meeting of Clinical Pharmacology and 23rd Meeting of Toxicology
(Lisbon, Portugal)
2024/01/23 Blueberry leaf biomass: a nutraceutical for Multiple Sclerosis’ relief targeting the gut-immune system-CNS axis Meet my Science
CIBB - Center for Innovative Biomedicine and Biotechnology CNC | iCBR | UC-Biotech (Coimbra, Portugal)
2023/02/02 Pro-inflammatory cues towards remyelination: novelty effects of a blueberry leaves-based nutraceutical 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology
(Coimbra, Portugal)
2022/11/17 A blueberry-based prebiotic improves gut Th17/Treg imbalance and central impairments in experimental multiple sclerosis National Congress of Neurology
(Aveiro, Portugal)
2022/02/09 A blueberry-based prebiotic strategy improves intestinal Th17/Treg imbalance and central impairments in experimental Multiple Sclerosis 52nd Meeting of the Portuguese Society of Pharmacology, 40thMeeting of Clinical Pharmacology and 21st Meeting of Toxicology
(Porto, Portugal)
2021/02/19 Sub-Cronic Toxicity Evaluation of Green Enzyme-Assisted Processing of Senescent Vaccinium Leaves Biomass in Mice 51st Meeting of the Portuguese Society of Pharmacology, 39th Meeting of Clinical Pharmacology and 20th Meeting of Toxicology
Faculdade de Farmácia da Universidade de Lisboa (Lisbon, Portugal)

Orientação

Título / Tema
Papel desempenhado
Curso (Tipo)
Instituição / Organização
2023/09/01 - 2024/09/30 Preclinical evaluation of the nutraceutical potential of blueberry-based antioxidant fiber in experimental Multiple Sclerosis
Coorientador
Masters in Pharmacy (Mestrado)
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2021/09/01 - 2022/08/01 Gut-immune-CNS axis modulation in Multiple Sclerosis: An update
Coorientador
Bachelor in Pharmacy (Licenciatura/Bacharelato)
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
2020/11/27 - 2021/08/01 Metabolic changes underlying the pathophysiology of multiple sclerosis - new therapeutic opportunities
Coorientador
Bachelor in Pharmacy (Licenciatura/Bacharelato)
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação)
Instituição / Organização
2023/01/01 - 2023/02/03 Organisation of the 53rd Meeting of the Portuguese Society of Pharmacology, 41st Meeting of Clinical Pharmacology and 22nd Meeting of Toxicology (2023/02/01 - 2023/02/03)
Congresso (Membro da Comissão Organizadora)
CNC.IBILI, Portugal

Participação em evento

Descrição da atividade
Tipo de evento
Nome do evento
Instituição / Organização
2023/01/16 - 2023/01/27 RESETageing project
Oficina (workshop)
RESETageing project aims at enhancing the scientific and innovation competences of University of Coimbra, building an innovation and entrepreneurship environment by nurturing an entrepreneurial and risk-taking spirit among UC students and researchers.
Instituto Pedro Nunes, Portugal
Distinções

Prémio

2021 1º prémio no concurso de ideias "From Linear to Circular Ideas" - 1ª Edição da Rede de Campus Sustentável (RCS)
Universidade de Coimbra, Portugal

Universidade Tecnológica Federal do Paraná - Câmpus Medianeira, Brasil

Instituto Politécnico de Castelo Branco, Portugal

Smart Waste Portugal, Portugal

Intraplás, Portugal

Entogreen, Portugal

Delta, Portugal

Laboratório Colaborativo para a Economia Circular, Portugal

Associação Natureza Portugal, Portugal