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My name is Margarida Pacheco, I studied Biochemistry (BSc and MSc) at the University of Minho, Braga, Portugal. During my master thesis I worked on the development and characterization of various protein variants, through genetic engineering, with the objective to improve the stability of a cold-adapted enzyme in acidic pHs. During that year I worked in the areas of microbiology, genetic engineering, bioinformatics and techniques of protein production and characterization. On July 2018 I was awarded with a research fellowship at i3Bs Research Group and my research focus started to change and became closer to biomaterials. My first works at i3Bs were dedicated to the functionalization of polymers (both degradable and non-degradable) for urological applications. In 2019 I engaged the PhD and since October 2019 I have been working on my PhD project which focuses on a comprehensive characterization of biodegradable metal's corrosion and encrustation propensity in urinary tract environment, as well as their biocompatibility and possible antibacterial activity, envisioning the utilization of biodegradable metals, specifically Mg alloys, for biodegradable metallic ureteral stent development.
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Identificação

Identificação pessoal

Nome completo
Margarida Pacheco

Nomes de citação

  • Pacheco, Margarida

Identificadores de autor

Ciência ID
131D-75DD-387A

Endereços de correio eletrónico

  • amrpacheco297@gmail.com (Profissional)
  • margarida.pacheco@i3bs.uminho.pt (Profissional)

Telefones

Telefone
  • 253510900 (Profissional)
Telemóvel
  • 916368029 (Pessoal)

Moradas

  • AvePark - Parque de Ciência e Tecnologia, Zona Industrial da Gandra, 4805-017, Barco, Guimarães, Portugal (Profissional)
  • Bouça de Montão nº 12, 4880-165, Mondim de Basto, Mondim de Basto, Portugal (Pessoal)

Websites

Domínios de atuação

  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais
  • Ciências Médicas e da Saúde - Medicina Clínica - Urologia e Nefrologia
  • Ciências Naturais - Ciências Biológicas - Bioquímica
  • Ciências Naturais - Ciências Biológicas - Biologia Celular
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador independente (B2) Utilizador proficiente (C1) Utilizador proficiente (C1) Utilizador proficiente (C1)
Português Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Formação
Grau Classificação
2019/10/01 - 2023/10/01
Em curso
 Tissue Engineering, Regenerative Medicine and Stem Cells (TERM(SC) (Doutoramento)
Biomaterials Biodegradables and Biomimetics, Portugal
2018/01/08 - 2018/03/25
Concluído
 Engenharia de Tecidos e Medicina Regenerativa (Outros)
Universidade do Minho, Portugal
 18
2015/09/01 - 2017/12/19
Concluído
 Bioquímica Aplicada (Mestrado)
Especialização em Biomedicina
Universidade do Minho, Portugal
"Deciphering the role of exposed surface residues in protein stability" (TESE/DISSERTAÇÃO)
 17,4
2012/09/01 - 2015/07/31
Concluído
 Bioquímica (Licenciatura)
Especialização em Bioquímica
Universidade do Minho, Portugal
"Bioatividades de própolis" (TESE/DISSERTAÇÃO)
 15,4
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2019/10/01 - 2023/10/01 Investigador (Investigação) Biomaterials Biodegradables and Biomimetics, Portugal
Universidade do Minho, Portugal
2018/07/02 - 2019/09/30 Investigador (Investigação) Biomaterials Biodegradables and Biomimetics, Portugal
Universidade do Minho, Portugal
Projetos

Bolsa

Designação Financiadores
2019/10/01 - 2023/10/01 Ureteral stenting using biodegradable metals
SFRH/BD/145285/2019
Bolseiro de Doutoramento
Biomaterials Biodegradables and Biomimetics, Portugal
 Fundação para a Ciência e a Tecnologia

Associação para a Inovação e Desenvolvimento da FCT
Em curso
2019/01/01 - 2019/09/30 ICVS/3B’s - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group
info:eu-repo/grantAgreement/FCT/5876/147272/PT
 Fundação para a Ciência e a Tecnologia
Concluído
2018/07/02 - 2019/03/31 ELASTISLET
646075
Bolseiro de Investigação
Horizon 2020
Em curso

Outro

Designação Financiadores
2021/09/05 - 2023/11/30 Additive Manufacturing for the Life Sciences
2019-00029
Bolseiro de Cientista Convidado
Uppsala Universitet, Suécia
Em curso
2019/10/14 - 2023/10/13 Green Chemical Engineering Network towards upscaling sustainable processes
CA18224
Outra
Universidade Nova de Lisboa, Portugal
Em curso
2020/07/01 - 2023/09/30 A metal-based biodegradable ureteral stent
047112
Bolseiro de Doutoramento
Biomaterials Biodegradables and Biomimetics, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
Produções

Publicações

Artigo em revista
  1. Pacheco, Margarida; Aroso, Ivo M.; Silva, Joana M.; Lamaka, Sviatlana V.; Bohlen, Jan; Nienaber, Maria; Letzig, Dietmar; et al. "Understanding the corrosion of Mg alloys in in vitro urinary tract conditions: A step forward towards a biodegradable metallic ureteral stent". Journal of Magnesium and Alloys 11 11 (2023): 4301-4324. http://dx.doi.org/10.1016/j.jma.2023.10.002.
    Publicado • 10.1016/j.jma.2023.10.002
  2. Gomes, Inês V.; Pacheco, Margarida; Nienaber, Maria; Neves, Sara C.; Mei, Di; Barros, Alexandre; Reis, Rui L.; Alves, José L.; Puga, Helder. "Shielding AZ91D-1%Ca from corrosion through ultrasound melt treatment: A study for stent design". Journal of Magnesium and Alloys 11 8 (2023): 2901-2915. http://dx.doi.org/10.1016/j.jma.2023.07.013.
    10.1016/j.jma.2023.07.013
  3. Domingues, Beatriz; Pacheco, Margarida; Cruz, Julia E.; Carmagnola, Irene; Teixeira-Santos, Rita; Laurenti, Marco; Can, Fusun; et al. "Future Directions for Ureteral Stent Technology: From Bench to the Market". Advanced Therapeutics 5 1 (2021): 2100158. http://dx.doi.org/10.1002/adtp.202100158.
    10.1002/adtp.202100158
  4. Mei, Di; Wang, Cheng; Nienaber, Maria; Pacheco, Margarida; Barros, Alexandre; Neves, Sara; Reis, Rui L.; et al. "Corrosion behavior of Mg wires for ureteral stent in artificial urine solution". Corrosion Science 189 (2021): 109567. http://dx.doi.org/10.1016/j.corsci.2021.109567.
    10.1016/j.corsci.2021.109567
  5. Pacheco, Margarida. "ENIUS. European Network of multidisciplinary research to Improve the Urinary Stents. COSTS Actions. CA16217. European Cooperation in Science & Technology". Urolithiasis 48 6 (2020): 553-559. http://dx.doi.org/10.1007/s00240-020-01218-2.
    10.1007/s00240-020-01218-2
  6. Pacheco, Margarida; Barros, Alexandre; Aroso, Ivo M.; Autorino, Riccardo; Lima, Estêvão; Silva, Joana M.; Reis, Rui L.. "Use of hemostatic agents for surgical bleeding in laparoscopic partial nephrectomy: Biomaterials perspective". Journal of Biomedical Materials Research Part B: Applied Biomaterials (2020): 1-25. http://dx.doi.org/10.1002/jbm.b.34637.
    Publicado • 10.1002/jbm.b.34637
Capítulo de livro
  1. Pacheco, Margarida; Domingues, Beatriz; Lima, Estêvão; Reis, Rui L.; Barros, Alexandre. "Hydrogels as stents". In Hydrogels for Tissue Engineering and Regenerative Medicine, 467-482. Elsevier, 2024.
    Publicado • 10.1016/b978-0-12-823948-3.00023-3
  2. Pacheco, Margarida; Silva, Joana M.; Aroso, Ivo; Lima, Estêvão; Barros, Alexandre; Reis, Rui L.. "Biomaterials for Ureteral Stents: Advances and Future Perspectives". In Urinary Stents, 197-208. Springer International Publishing, 2022.
    Publicado • 10.1007/978-3-031-04484-7_17
Poster em conferência
  1. Pacheco, Margarida; Lamaka, Sviatlana V.; Zheludkevich, Mikhail; Bohlen, Jan; Nienaber, Maria; Letzig, Dietmar; Hassila, Carl-Johan; et al. "Suitability of additive manufacturing for biodegradable urinary devices: an in vitro study". Trabalho apresentado em 33rd Annual Conference of the European Society for Biomaterials, 2023.
  2. Pacheco, Margarida; Aroso, Ivo; Silva, Joana M.; Lima, Estêvão; Reis, Rui L.. "Insights on the corrosion and encrustation of biodegradable Mg alloys in urinary tract environment". Trabalho apresentado em Final FoReCaST Conference, 2021.
  3. Pacheco, Margarida; Aroso, Ivo M.; Joana Silva (5919-006C-53B8); Lima, Estêvão; Barros, Alexandre; Reis, Rui L.. "URETERAL STENTING USING BIODEGRADABLE METALS". Trabalho apresentado em TERM-STEM 2019, 2019.
  4. Pacheco, Margarida; Joana Silva (5919-006C-53B8); Aroso, Ivo M.; Eduardo Silva (521D-E545-32BC ); Lima, Estêvão; Barros, Alexandre; Reis, Rui L.. "Curcumin impregnation by supercritical fluid technology in silicon based ureteral stents". Trabalho apresentado em FoReCaST 2nd Workshop, 2019.
  5. Pacheco, Margarida; Barros, Alexandre; Aroso, Ivo M.; Joana Silva (5919-006C-53B8); Reis, Rui L.; Lima, Estêvão. "Drug-eluting Biodegradable Ureteral Stents: Targeting urothelial tumors of upper urinary tract cancer". Trabalho apresentado em Computational Approaches to Ureteric Stent Design, 2018.
  6. Pacheco, Margarida; Mário Barroca; Bruno Oliveira; Paulo Veloso; Gustavo Santos; Tony Collins. "Deciphering the role of exposed surface residues in protein stability". Trabalho apresentado em I Simpósio em Bioquímica Aplicada 2017, 2017.
Resumo em conferência
  1. Pacheco, Margarida; Ivo Aroso; Joana Silva (5919-006C-53B8); Sviatlana Lamaka; Mikhail Zheludkevich; Jan Bohlen; Maria Nienaber; et al. "Insights on the degradation profile of magnesium alloys in a simulated urinary tract environment". Trabalho apresentado em 12th Symposium on Biodegradable Metals, Alicante, 2021.
    Submetido
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/08/25 Additive manufacturing of biodegradable Mg1%Y-based ureteral stents: Understanding the corrosion under simulated urinary tract environment 15th International Symposium on Biodegradable Metals
(Cetraro, Itália)
2022/10/02 Biodegradable metals for ureteral stents: understanding the degradation profile under simulated urinary tract environment 39th World Congress of Endourology and Uro-technology
(San Diego, Estados Unidos)
2022/08/28 Towards the development of a biodegradable metallic ureteral stent: Characterizing the corrosion and encrustation tendency of Mg alloys under in vitro urinary tract conditions 14th International Symposium on Biodegradable Metals
Hotel Alicante Golf (Alicante, Espanha)
2022/05/18 Inside the corrosion and encrustation trend of biodegradable Mg alloys: towards the development of a biodegradable metallic ureteral stent European Society for Bioresorbable Implants
Danube Private University for Dentistry and Medicine (Krems, Áustria)
2022/03/02 Understanding the behaviour of biodegradable Mg alloys under in vivo urinary tract conditions Workshop "Latest Advances in Urinary Stents. Multidisciplinary approach“
ENIUS - European Network of Multidisciplinary Research to Improve the Urinary Stents (Istanbul, Turquia)
2021/10/07 Insights on the degradation and encrustation propensity of biodegradable metals in urinary tract environment II Virtual ENIUS Workshop. Next steps for Urinary Stents Research
ENIUS - European Network of Multidisciplinary Research to Improve the Urinary Stents
2021/03/23 Biodegradable metals for ureteral stents: understanding the degradation profile under simulated urinary tract environment Virtual ENIUS Workshop. Latest advances in Urinary Stents. Biomaterials, Technology and Coatings.
2019/09/26 Anticancer and antibacterial effect of curcumin-loaded ureteral stents Advances in Urinary Stents. Biomaterials, Coatings and Drug Eluting Stents (DES)
European Network of multidisciplinary research to Improve the Urinary Stents (ENIUS) (Lublin, Polónia)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2021/10/28 - 2021/10/29 The conference addressed the most relevant topics related to tissue-engineered models for drug screening, cell/tissue interactions within 3D cell co-cultures, advanced nanotechnology tools in cancer research, and high throughput analysis of cancer biomarkers to decipher the tumorigenesis process and metastasis.
Conferência
 Final FoReCaST Conference
Biomaterials Biodegradables and Biomimetics, Portugal
2021/10/14 - 2021/10/15 Talks about the last results of the group on additive manufacturing and 3D printing, as well as the presence of invited speakers, experts in this area.
Encontro
 Additive Manufacturing for the Life Sciences Consortium Meeting
Uppsala Universitet Polacksbacken Ångströmlaboratoriet, Suécia
2021/10/04 - 2021/10/04 Advances in ureteral stents
Conferência
 On line CONFERENCE. ENIUS Working Group 4&5
Centro de Cirugía de Mínima Invasión Jesús Usón, Espanha
2021/09/30 - 2021/09/30 Fluid dynamics in urinary stents
Conferência
 Computation simulation, biomedical fluid dynamics in urinary stents
Centro de Cirugía de Mínima Invasión Jesús Usón, Espanha
2021/09/29 - 2021/09/29 Complications of ureteral stents and stenting on pediatric patients
Conferência
Centro de Cirugía de Mínima Invasión Jesús Usón, Espanha
2021/06/16 - 2021/06/18 Last advances in tissue engineering, regenerative medicine, and stem cells research
Conferência
 TERM STEM 2021
Biomaterials Biodegradables and Biomimetics, Portugal
2021/06/14 - 2021/06/16 Hallmarks in cancer and the development of diagnostic tools
Conferência
 Third Forecast Workshop
Biomaterials Biodegradables and Biomimetics, Portugal
2019/11/09 - 2019/11/09 This event aimed at disseminating and discussing the most recent discoveries and improvements in urology
Simpósio
 2nd Portuguese Symposium on Research and Innovation in Urology
Universidade do Porto Porto Business School, Portugal
2019/07/08 - 2019/07/10 The First Achilles Conference focused on Molecular and biological mechanisms of tendon homeostasis and repair. The event was organized to promote a close interaction between highly skilled experts in the field with students and young researchers interested in key aspects of tendon development, disease and regeneration.
Conferência
 First Achilles Conference
Biomaterials Biodegradables and Biomimetics, Portugal
2019/01/08 - 2019/01/21 Cell Culture Lab Training
Outro
 Cell Culture Lab Training
Biomaterials Biodegradables and Biomimetics, Portugal
2018/10/26 - 2018/10/27 The main objective of this event was to discuss the ultimate developments on the utilization of precision chemical methodologies applied to natural-based systems for the development of multifunctional biomedical devices. Some of the main themes regarding this research topic were adressed, such as supramolecular systems, Cell-ECM interactions, Pathological protein aggregation, Drug-delivery systems, Top-Down Fabrication methodologies, Modulating cell behaviour using mechanical stimuli, among others.
Conferência
 Chem2Nature
Biomaterials Biodegradables and Biomimetics, Portugal
2018/10/23 - 2018/10/24 This conference themed cutting-edge basic and translational research in skin-related diseases and disorders, promoting the interaction of highly skilled experts in this area, counting also with short presentations from young researchers.
Conferência
 Gene2Skin
Biomaterials Biodegradables and Biomimetics, Portugal
2018/10/10 - 2018/10/10 Universal Mechanical Testing Equipment Training
Outro
 Universal Mechanical Testing Equipment Training
Biomaterials Biodegradables and Biomimetics, Portugal
2018/09/04 - 2018/09/04 Vacuum Oven Training Vacuum Oven Training
Biomaterials Biodegradables and Biomimetics, Portugal
2017/04/07 - 2017/04/10 The objective of this activity was to generate and dissiminate knowledge through seminars from the most prestigious speakers, and by promoting the discussion of various different topics by participants, focusing on the participation of students. Altogether, it was a mean to create opportunities for students to contact with prestigious researchers and expand horizons.
Encontro
 X ENEBIOQ - Ciência nas tuas mãos
Universidade do Minho, Portugal
2017/04 - 2017/04 X ENEBIOQ – Ciência nas Tuas Mãos
Encontro
 X ENEBIOQ – Ciência nas Tuas Mãos
Universidade do Minho, Portugal
2016/04 - 2016/04 Flow Cytometry, from research to clinical applications
Oficina (workshop)
 Flow Cytometry, from research to clinical applications
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015 - 2015 Que plantas utilizaria para a produção de um conservante alimentar?
Outro
 iSci Interface Ciência
Universidade do Minho, Portugal
2015 - 2015 VI Jornadas de Bioquímica
Encontro
 VI Jornadas de Bioquímica
Universidade do Minho, Portugal
2014 - 2014 V Jornadas de Bioquímica
Encontro
 V Jornadas de Bioquímica
Universidade do Minho, Portugal
2013 - 2013 IV Jornadas de Bioquímica
Encontro
 IV Jornadas de Bioquímica
Universidade do Minho, Portugal

Expedição científica

Descrição da atividade Instituição / Organização
2022/05/09 - 2022/12/17 During this work it is intended to investigate the suitability of Additive Manufacturing (AM) for the development of ureteral stents, using Mg1Y powder. The main objective is to develop a biodegradable metallic ureteral stent. Uppsala Universitet Polacksbacken Ångströmlaboratoriet, Suécia
2021/09/05 - 2021/10/26 Gain expertise on Additive Manufacturing (AM) - Laser Powder Bed Fusion (LPBF) in other to use this technique to develop ureteral stent prototypes. Uppsala Universitet Polacksbacken Ångströmlaboratoriet, Suécia
Distinções

Prémio

2021 The Best Research Oral Presentation Award
2019 PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2019 Research Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2018 Research Fellowship
Horizon 2020, Bélgica