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Miguel Lino (ML) is a researcher at the University of Coimbra and affiliated with the Centre for Innovative Biomedicine and Biotechnology (CIBB). He has an MSc in Biomedical Engineering (IST, Technical University of Lisbon) and a PhD in Biosciences (University of Coimbra, 2017). ML has acquired strong expertise in different fields of knowledge: biomedical engineering, biology, biomaterials and nanotechnology. In his PhD and in the following years, ML made a significant contribution to the development of a cutting-edge research field in the lab of Dr Lino Ferreira, related to the creation of light-triggerable formulations for the intracellular delivery of biomolecules. The work gave origin to one international patent (PCT/IB2016/056229) and publications in prestigious nanotechnology journals (ACS Nano, Nanoscale), which have been highlighted by the national press. In his postdoctoral career, ML has worked on the development of sEV therapeutics for the treatment of cardiovascular/brain disorders, mainly focused on ischemic diseases and sEV targeting strategies. Several articles in high-impact journals (J. of Controlled Release, J. of Extracellular Vesicles, ACS Nano, Nanoscale) have already resulted from his contribution to this field. Overall, he published 20 articles in peer-reviewed journals (all in Q1; average IF>9.4). In the last 4 years, ML was able to increase his scientific independence. From 2020 until 2021, ML was an invited auxiliary researcher at the Faculty of Medicine of the University of Coimbra. Since 2021 he was able to secure: (i) a contract of junior researcher in the national call for Scientific Employment Stimulus (top 8%); (ii) funding as PI and co-PI for FCT exploratory projects (100k €) on sEV-based therapeutics; (iii) mobility grants to perform a collaborative project at Imperial College London. Over the years, he has supervised 2 PhD students, a team of 4 researchers (1 postdoc and 3 MSc fellows) dedicated to sEV therapies, 3 researchers (1 postdoc and 2 MSc fellows) working on sEVs to reverse cell senescence and he has mentored 6 visiting students/researchers. In the last years, he has built a network of contacts with international experts from top institutions: Dr Costanza Emanueli and Dr Césare Terracciano (Imperial College London), Dr Marina Resmini (Queen Mary University of London), Dr Tomas Sobrino (University of Santiago de Compostela), Dr Ana Teixeira (Karolinska Institute), Dr Diana Nascimento (i3S) and Dr Chiara Brovarone (Polytechnic University of Turin). Besides his research activities, he is an invited professor of the syllabus “Regenerative Medicine” of the MSc program in Biomedical Engineering (Univ. Coimbra) and has contributed with lectures for the PhD programme in Biomedicine and Experimental Biology (CNC-UC). From 2019 until 2023, he was the coordinator of the section “Cell Therapies and Tissue Engineering” of the Portuguese Society for Stem Cells and Cell Therapies and since 2023 he is a member of the scientific council of the Multidisciplinary Institute of Ageing. His scientific contributions have been recognized at national and international levels: he has been invited to be a jury member in 7 MSc defences and 4 PhD defences; he gave talks at conferences/symposiums (6 by invitation, 1 keynote lecture); He received 5 poster awards at international conferences. He was invited to be an abstract reviewer for the 7th TERMIS World Congress and to become a review editor of Frontiers in Medical Engineering. He has acted as a reviewer for different journals (ACS Biomaterials Science & Engineering; Cells).
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Identificação

Identificação pessoal

Nome completo
Miguel Maria da Fonseca Miranda Ferreira Lino

Nomes de citação

  • Lino, Miguel

Identificadores de autor

Ciência ID
1C1F-4287-AF90
ORCID iD
0000-0001-6011-0058

Domínios de atuação

  • Ciências da Engenharia e Tecnologias - Nanotecnologia - Nanomateriais
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Biomateriais
  • Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo

Idiomas

Idioma Conversação Leitura Escrita Compreensão Peer-review
Inglês Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2) Utilizador proficiente (C2)
Português (Idioma materno)
Formação
Grau Classificação
2017
Concluído
 PhD in Biosciences, Specialization in biotechnology (Doutoramento)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Light-triggerable Nanomaterials for the Delivery of Biomolecules" (TESE/DISSERTAÇÃO)
 Approved with praise and distinction
2007
Concluído
 Integrated Masters in Biomedical Engineering (Mestrado)
Universidade de Lisboa, Portugal
"Análise ecográfica, estrutural e biomecânica de tendões" (TESE/DISSERTAÇÃO)
 17
Percurso profissional

Ciência

Categoria Profissional
Instituição de acolhimento 		Empregador
2022/06/01 - Atual Investigador (Investigação) Universidade de Coimbra, Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
2021/06/01 - 2022/05/31 Investigador Auxiliar Convidado (carreira) (Investigação) Faculty of Medicine of the University of Coimbra, Portugal
2021/08 - 2022/03 Investigador visitante (Investigação) Faculty of Medicine of the University of Coimbra, Portugal
Imperial College London, Reino Unido
2018/10/01 - 2021/03/31 Investigador Contratado (Investigação) Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal
Centro de Inovação em Biomedicina e Biotecnologia (CIBB), Portugal

Outros

Categoria Profissional
Instituição de acolhimento 		Empregador
2021/03/01 - 2021/05/31 Scientific report writer (responsible for the elaboration of the periodic and final technical reports of the ERA@UC project) Faculty of Medicine of the University of Coimbra, Portugal
Faculty of Medicine of the University of Coimbra, Portugal
2017/11/01 - 2018/09/30 Post-doctoral researcher (project ERA@UC) CNC.IBILI, Portugal
2016/02/01 - 2017/10/31 Research assistant (project Nanotrigger ERC Grant Agreement nº 307384) CNC.IBILI, Portugal
2012/01/01 - 2017/06/20 PhD student (Doctoral program in Biosciences, Specialization in biotechnology) Universidade de Coimbra, Portugal
2009/09/01 - 2011/12/31 Research assistant. Development of antimicrobial nanomaterials and coatings for biomedical application Matera Lda, Portugal
Projetos

Bolsa

Designação Financiadores
2021/05 - Atual Synaptic regulation by chronic stress-induced microRNA-186-5p in the prefrontal cortex
HR21-01077
Investigador
Obra Social La Caixa
Em curso
2017/11/01 - 2018/09/30 ERA@UC. Ref 669088. ERA Chair in Cellular and Molecular Biology of Ageing
Ref 669088
Bolseiro de Pós-Doutoramento
European Commission
Em curso

Projeto

Designação Financiadores
2023/01/01 - Atual Design and development of polymer brush functionalized exosomes for brain targeted delivery of miRNA
2022.02803.PTDC
Co-Investigador Responsável (Co-IR)
2022/01/01 - Atual A gene-editing nanoparticle formulation for retinal degeneration diseases
EXPL/BIA-CEL/0989/2021
Investigador
Fundação para a Ciência e a Tecnologia
Em curso
2021/01/01 - Atual Engineered extracellular vesicles for neuroprotection
EXPL/BTM-ORG/1348/2021
Investigador responsável
Fundação para a Ciência e a Tecnologia
Em curso
2018/10/01 - Atual EXO-HEART: Protecção e regeneração cardíaca mediada pela administração sistémica e direcionada de exosomas.
PTDC/BTM-SAL/29919/2017
Investigador
Fundação para a Ciência e a Tecnologia
Em curso
2018/07/06 - Atual A light-activatable nanoparticle library for the delivery of RNA-based therapies
PTDC/EQU-EQU/29414/2017
Investigador Pós-doutorado
CNC.IBILI, Portugal
 Fundação para a Ciência e a Tecnologia
Em curso
2016 - 2019 Plataformas terapêuticas para acidentes vasculares cerebrais
SII&DT 3386 StrokeTherapy
Investigador
Concluído

Outro

Designação Financiadores
2012/11/01 - 2017/06/20 Triggerable nanomaterials to modulate cell activity
307384
Bolseiro de Doutoramento
CNC.IBILI, Portugal
 European Research Council
Concluído
2010 - 2012 Antimicrobial coatings and materials based in polycationic polymers
0000
Investigador
IAPMEI
Produções

Publicações

Artigo em conferência
  1. Henriques-Antunes H; Renato Cardoso; Alessandra Zonari; Joana Correia; Leal, Ermelindo C; Adrien Jimenez-Balsa; Lino, Miguel; Gomes, Célia. "Oral Talks - Orchestrating the release of small extracellular vesicles with a light-triggerable hydrogel". 2020.
    10.1111/eci.13108
  2. Banerjee, Arnab; Rondao, Tiago; Sereno, Jose; Alves, Vitor; Lino, Miguel; Ribeiro, Andreia; Abrunhosa, Antero; Ferreira, Lino. "PET imaging and in vivo bio-distribution of small extracellular vesicles". 2019.
Artigo em revista
  1. Susana Simões; Lino, Miguel; Angela Barrera; Catarina Rebelo; Francesca Tomatis; Andreia Vilaça; Christopher Breunig; et al. "Near infrared light-activated formulation for the spatial controlled release of CRISPR-Cas9 ribonucleoprotein for brain gene editing". Angewandte (2024): https://doi.org/10.1002/anie.202401004.
    No prelo
  2. Andreia Vilaça; Miguel Lino; Hugo Fernandes; Leon de Windt; Lino Ferreira. "Extracellular vesicle transfer of lncRNA H19 splice variants to cardiac cells". Molecular Therapy - Nucleic Acids (2024): 10.1016/j.omtn.2024.102233.
    Publicado
  3. Roberta Bilardo; Adele Leggieri; Francesca Tomatis; Federico Traldi; Alena Vdovchenko; Eleonora Rizzi; Miguel Lino; et al. "N-isopropylacrylamide based nanogels crossing the blood-brain barrier: evidence of high in vitro internalization in human endothelial cells and in vivo permeation in zebrafish". Small (2024):
    Aceite para publicação
  4. Inês Albino; Elena Ambrosetti; Ana Teixeira; Paula Sampaio; Miguel M. Lino; Lino Ferreira. Autor correspondente: Miguel M. Lino. "Dual Ligand Cooperation in Surface Engineering Drives Extracellular Vesicle Transport at the Blood-Brain Barrier". (2024):
    Submetido
  5. Arnab Banerjee; Lino, Miguel; Carlos Jesus; Quélia Ribeiro; Antero Abrunhosa; Lino Ferreira. "Imaging platforms to dissect the in vivo communication, biodistribution and controlled release of extracellular vesicles". Journal of Controlled Release 360 (2023): 549-563. https://www.sciencedirect.com/science/article/abs/pii/S0168365923004224.
    Publicado
  6. João André Sousa; Catarina Bernardes; Sara Bernardo-Castro; Miguel Lino; Inês Albino; Lino Ferreira; José Brás; et al. "Reconsidering the role of blood-brain barrier in Alzheimer’s disease: From delivery to target". Frontiers in Aging Neuroscience 15 (2023): https://doi.org/10.3389/fnagi.2023.1102809.
    Publicado
  7. Lino, Miguel; Rondão, Tiago; Arnab Banerjee; Inês Aires; Magda Rodrigues; Tiago Reis; António Santinha; et al. "Small extracellular vesicles administered directly in the brain promote neuroprotection and decrease microglia reactivity in a stroke mouse model". Nanoscale (2023): https://pubs.rsc.org/en/content/articlelanding/2023/nr/d3nr03861k.
    Publicado
  8. Fernandes, Hugo; Alessandra Zonari; Ricardo Abreu; Sezin Aday; Barão, Marta; Inês Albino; Miguel Lino; et al. "Extracellular vesicles enriched with an endothelial cell pro-survival microRNA impacts skin tissue regeneration". Molecular Therapy - Nucleic Acids (2022): https://doi.org/10.1016/j.omtn.2022.03.018.
    Publicado
  9. Akhilesh Rai; Rafaela Ferrão; Denise Marta; Andreia Vilaça; Lino, Miguel; Tiago Rondão; Artur Paiva; Lino Ferreira. "Antimicrobial peptide-tether dressing able to enhance wound healing by tissue contact". ACS Applied Materials & Interfaces (2022): https://doi.org/10.1021/acsami.2c06601.
    Publicado
  10. Lino, Miguel; Susana Simões; Francesca Tomatis; Inês Albino; Angela Barrera; Denis Vivien; Tomas Sobrino; Lino Ferreira. "Engineered extracellular vesicles as brain therapeutics". Journal of Controlled Release (2021): https://doi.org/10.1016/j.jconrel.2021.08.037.
    Publicado
  11. Ricardo C. Abreu; Cristiana V. Ramos; Clarissa Becher; Miguel Lino; Carlos Jesus; Paula A. Costa Martins; Patrícia A. T. Martins; et al. "Exogenous loading of miRNAs into small extracellular vesicles". Journal of Extracellular Vesicles 10 10 (2021): https://doi.org/10.1002%2Fjev2.12111.
    Publicado • 10.1002/jev2.12111
  12. Sara Bernardo-Castro; Inês Albino; Ángela María Barrera-Sandoval; Francesca Tomatis; João André Sousa; Emanuel Martins; Susana Simões; et al. "Therapeutic Nanoparticles for the Different Phases of Ischemic Stroke". Life 11 6 (2021): 482-482. https://doi.org/10.3390%2Flife11060482.
    10.3390/life11060482
  13. Francisco, Vitor; Lino, Miguel; Ferreira, Lino. "A near infrared light-triggerable modular formulation for the delivery of small biomolecules". Journal of Nanobiotechnology 17 1 (2019): http://dx.doi.org/10.1186/s12951-019-0530-y.
    10.1186/s12951-019-0530-y
  14. Helena Henriques-Antunes; Renato M. S. Cardoso; Alessandra Zonari; Joana Correia; Ermelindo C. Leal; Adrián Jiménez-Balsa; Miguel M. Lino; et al. "The Kinetics of Small Extracellular Vesicle Delivery Impacts Skin Tissue Regeneration". ACS Nano (2019): https://doi.org/10.1021/acsnano.9b00376.
    10.1021/acsnano.9b00376
  15. Arnab Banerjee; Vitor Alves; Tiago Rondão; José Sereno; Ângela Neves; Miguel Lino; Andreia Ribeiro; Antero J. Abrunhosa; Lino S. Ferreira. "A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles". Nanoscale 11 28 (2019): 13243-13248. https://doi.org/10.1039/C9NR02512J.
    10.1039/C9NR02512J
  16. Miguel M. Lino; Susana Simões; Andreia Vilaça; Helena Antunes; Alessandra Zonari; Lino Ferreira. "Modulation of Angiogenic Activity by Light-Activatable miRNA-Loaded Nanocarriers". ACS Nano (2018): https://doi.org/10.1021/acsnano.7b07538.
    10.1021/acsnano.7b07538
  17. Adrián Jiménez-Balsa; Sandra Pinto; Emanuel Quartin; Miguel M. Lino; Vitor Francisco; Lino Ferreira. "Nanoparticles Conjugated with Photocleavable Linkers for the Intracellular Delivery of Biomolecules". Bioconjugate Chemistry (2018): https://doi.org/10.1021%2Facs.bioconjchem.7b00820.
    10.1021/acs.bioconjchem.7b00820
  18. Miguel M. Lino; Lino Ferreira. "Light-triggerable formulations for the intracellular controlled release of biomolecules". Drug Discovery Today (2018): https://doi.org/10.1016%2Fj.drudis.2018.01.019.
    10.1016/j.drudis.2018.01.019
  19. Miguel M. Lino; Susana Simões; Sónia Pinho; Lino Ferreira. "Intracellular delivery of more than one protein with spatio-temporal control". Nanoscale (2017): https://doi.org/10.1039/C7NR02414B.
    10.1039/C7NR02414B
  20. Miguel M. Lino; Cristiana S.O. Paulo; Ana C. Vale; M. Fátima Vaz; Lino S. Ferreira. "Antifungal activity of dental resins containing amphotericin B-conjugated nanoparticles". Dental Materials 29 10 (2013): e252-e262. https://doi.org/10.1016%2Fj.dental.2013.07.023.
    10.1016/j.dental.2013.07.023
  21. Lino, Miguel. "Differential internalization of amphotericin B – Conjugated nanoparticles in human cells and the expression of heat shock protein 70". Biomaterials 34 21 (2013): 5281-5293. http://www.sciencedirect.com/science/article/pii/S014296121300358X.
    https://doi.org/10.1016/j.biomaterials.2013.03.048
  22. D. Botequim; J. Maia; M. M. F. Lino; L. M. F. Lopes; P. N. Simões; L. M. Ilharco; L. Ferreira. "Nanoparticles and Surfaces Presenting Antifungal, Antibacterial and Antiviral Properties". Langmuir 28 20 (2012): 7646-7656. https://doi.org/10.1021%2Fla300948n.
    10.1021/la300948n
Poster em conferência
  1. Carlos Jesus; Miguel Lino; Hugo Fernandes. "Scalable production of Extracellular Vesicles from Mesenchymal Stem Cells using a Hollow Fiber Bioreactor". Trabalho apresentado em 2nd MOVE Symposium, 2024.
  2. Cláudia M. Deus; Soares, Susana; Ferreira-Rodrigues, M; Rai, Akhilesh; Lino, Miguel; Ferreira, Lino. Autor correspondente: Cláudia M. Deus. "To reset the senescence program in senescent stem/progenitor cells by extracellular vesicles". Trabalho apresentado em 33rd Annual Conference of the European Society for Biomaterials, 2023.
  3. Miguel Lino. "Small extracellular vesicles for increased neuroprotection and modulation of microglia reactivity in stroke". Trabalho apresentado em 2nd Meeting of the Portuguese Network on Extracellular Vesicles, 2023.
  4. Miguel Lino. "Extracellular vesicles for neuroprotection and modulation of microglia reactivity in stroke". Trabalho apresentado em Joint Meeting ETRS & SPCE-TC, 2023.
  5. Magda Ferreira Rodrigues; Ana Carolina Mendes; Susana Soares; Eduardo Pires; Akhilesh Rai; Miguel Lino; Lino Ferreira. Autor correspondente: Miguel Lino. "Freeze-dried small extracellular vesicles (sEVs): the next step for sEV clinical applications". Trabalho apresentado em Biosystems in Toxicology and Pharmacology meeting., 2022.
  6. Inês Albino; Miguel Lino; Francesco Catapano; Costanza Emanueli; Lino Ferreira. Autor correspondente: Miguel Lino. "Engineered extracellular vesicles targeting ischemic endothelial cells". Trabalho apresentado em 12th International Meeting of the ¿Portuguese Society for Stem Cells ¿and Cell Therapies, 2022.
  7. Inês Albino; Miguel Lino; Lino Ferreira. Autor correspondente: Miguel Lino. "Engineered Extracellular Vesicles for Brain Targeting and Modulation". Trabalho apresentado em ESB-NANOSTEM Joint Sympoium, 2021.
  8. Lino, Miguel. "Lignt-controlled systems for the delivery of microRNAs". Trabalho apresentado em 4th COST Action CardioRNA MC and WG Meeting, 2020.
  9. Lino, Miguel. "Orchestrating the release of small extracellular vesicles with a light-triggerable hydrogel". Trabalho apresentado em ESCI 2019, 2019.
  10. Lino, Miguel; Susana Simões; Andreia Vilaça; Helena Antunes; Lino Ferreira. "Near-infrared triggered release of miRNAs for modulation of cell activity". Trabalho apresentado em XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
  11. Lino, Miguel; Susana Simões; Andreia Vilaça; Helena Henriques-Antunes; Alessandra Zonari; Lino Ferreira. "Spatio-temporal controlled delivery of miRNAs for modulation of angiogenic activity". Trabalho apresentado em 10th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2017.
  12. Lino, Miguel; Susana Simões; Andreia Vilaça; Helena Antunes; Alessandra Zonari; Lino Ferreira. "Modulation of cell activity by light-controlled delivery of miRNAS". Trabalho apresentado em 6th China-Europe Symposium on Biomaterials and Regenerative Medicine, 2017.
  13. Miguel Lino. "Light-controlled release of proteins from gold nanorods". Trabalho apresentado em 3rd Symposium in Nanoscience and Biomedical Nanotechnology, 2016.
Resumo em conferência
  1. Lino, Miguel; Rondão, Tiago; Banerjee, A; Aires, I; Rodrigues, M; Fernandes, Dominique; Freitas, J; et al. "Extracellular Vesicles Secreted by Mononuclear Cells from Umbilical Cord Blood Induce Neuroprotection and Angiogenesis and Attenuate Microglia Reactivity in a Mouse Model of Brain Ischemia". Trabalho apresentado em European Journal of Clinical Investigation, 2022.
    Publicado
Tese / Dissertação
  1. Lino, Miguel. "Light-triggerable nanomaterials for the delivery of biomolecules". Doutoramento, Universidade de Coimbra, 2017.

Propriedade Intelectual

Patente
  1. Lino, Miguel. 2017. "composition for controlled release of a biomolecule, method of preparation and uses thereof". Portugal.
Atividades

Apresentação oral de trabalho

Título da apresentação Nome do evento
Anfitrião (Local do evento)
2023/09 Engineering of extracellular vesicles for tissue engineering 33rd Annual Conference of the European Society for Biomaterials
(Davos)
2023/05/12 Engineered extracellular vesicles for the treatment of ischemic diseases (Invited Speaker) Workshop - ICNAS Pharma
ICNAS (Coimbra, Portugal)
2022/06/10 Extracellular vesicles secreted by mononuclear cells from umbilical cord blood induce neuroprotection and angiogenesis and attenuate microglia reactivity in a mouse model of brain ischemia ESCI 2022
European Society for Clinical Investigation (Bari, Itália)
2022/05/27 Engineered extracellular vesicles targeting the ischemic myocardium (Invited speaker) 8th COST Action CardioRNA MC and WG Meeting
COST Action CardioRNA (Pavia, Itália)
2022/03/11 Engineering strategies to boost the therapeutic potential of extracellular vesicles (Invited speaker) XII International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Portuguese Society for Stem Cells and Cell Therapies (Braga)
2021/03/04 Light-controlled delivery of biomolecules (Invited speaker) XVI ENEEB - National Biomedical Engineering Student Symposium
(Portugal)
2020/07/15 Advanced formulations for the delivery of biomolecules (Invited speaker) 2nd NanoStem Summer School
University of Coimbra (Coimbra, Portugal)
2019/12/19 Modulation of microRNA Delivery with Light (Invited speaker) CiBB meeting 2019
CiBB (Coimbra, Portugal)
2019/07 Controlled release of small extracellular vesicles by a light-triggerable hydrogel improves diabetic wound healing Controlled Release Society, Annual Meeting and Exposition
CRS (Valência, Espanha)
2019/05 Orchestrating the release of small extracellular vesicles with a light-triggerable hydrogel 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
ESCI (Coimbra, Portugal)
2019/05 What is needed from preclinical research to set up a clinical trial (Invited speaker) 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
ESCI (Coimbra, Portugal)
2019/05 PET imaging and in vivo biodistribution of small extracellular vesicles 53rd Annual Scientific Meeting of the European Society for Clinical Investigation
ESCI (Coimbra, Portugal)
2019/01/19 Controlled drug release systems Advanced workshop on biotechnology
Instituto de Educação e Cidadania (Portugal)
2018/12 Improved wound healing activity of small extracellular vesicles loaded in a light-triggerable hydrogel Secretome Without Borders
(Braga, Portugal)
2018 Controlling drug delivery with light (Invited speaker) IV Symposium of the Doctoral Program on Molecular and Environmental Biology,
(Braga, Portugal)
2016/07 Light controlled protein delivery German-Portuguese Student Workshop within the DAAD-Programme “Dialogue with Institutions of Higher Education in Southern Europe”
Biomaterials and Stem Cell based therapeutics Lab (Cantanhede, Portugal)
2016/05 Modulating protein delivery by opto-nanomedicine 10th World Biomaterials Congress,
(Montreal, Canadá)
2015/10 Modulating cell activity by opto-nanomedicine 9th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
(Oeiras, Portugal)

Orientação

Título / Tema
Papel desempenhado 		Curso (Tipo)
Instituição / Organização
2022/09 - Atual Combinatorial intervention to treat myocardial infarction
Coorientador de Ana Carolina Mendes
2018/09/01 - Atual New platforms for brain targeting by extracellular vesicles
Coorientador de Inês Maria Cunha Albino
Universidade de Coimbra, Portugal

Organização de evento

Nome do evento
Tipo de evento (Tipo de participação) 		Instituição / Organização
2023/09/08 - Atual Symposium "Extracellular Vesicle Bioengineering", 33rd Annual Conference of the European Society for Biomaterials, Davos, 2023 (Keynote speaker) (2023/09/08)
Simpósio (Coorganizador)
2016/06/27 - Atual Stem cell workshop: from basic research to clinical applications, Centro Hospitalar da Universidade de Coimbra, Portugal, June 27 th 2016. (2016/06/27)
Oficina (workshop) (Membro da Comissão Organizadora)
2023/12/06 - 2023/12/07 3rd RESET Ageing conference (2023/12/06 - 2023/12/07)
Conferência
 Universidade de Coimbra, Portugal
2021/06/30 - 2021/06/30 1st RESETageing conference (2021/06/30)
Conferência (Membro da Comissão Organizadora)
2019/06/28 - 2019/06/29 Conference: Ageing, models mechanisms and therapies. Responsible for the dissemination of the event in the media. (2019/06/28 - 2019/06/29)
Conferência (Membro da Comissão Organizadora)
 Universidade de Coimbra, Portugal
2018/07/27 - 2018/07/27 Workshop on “Ageing: models and therapies”, Faculty of Medicine, University of Coimbra, Polo III, June 27 th , 2018. (2018/07/27)
Oficina (workshop) (Membro da Comissão Organizadora)
 Universidade de Coimbra, Portugal
2016/07/07 - 2016/07/08 German-Portuguese student Workshop on “Translation in Biomaterials and Stem Cell Research”, Biocant, Cantanhede, Portugal, July 7-8 2016. The event was organized in collaboration with Dr. Tilo Pompe from the University of Leipzig, Germany, and funded by the DAAD program “Dialogue with Institutions of Higher Education in Southern Europe”. (2016/07/07 - 2016/07/08)
Oficina (workshop)
 Universidade de Coimbra, Portugal
2014/03/24 - 2014/03/24 Workshop on Stem cells: from basic research to therapeutic applications, Centro do Sangue e Transplantação de Coimbra, Coimbra, Portugal, March 24 th , 2014. (2014/03/24 - 2024/03/24)
Oficina (workshop) (Coorganizador)
2013/12 - 2013/12 German-Portuguese student Workshop on “Matrix Engineering meets Stem Cell Therapy”, Biocant, Cantanhede, Portugal, December 2013. (2013/12 - 2013/12)
Oficina (workshop) (Coorganizador)
2013/07/19 - 2013/07/19 First International Conference on Stem Cells for Drug Screening and Regenerative Medicine, Biocant, Cantanhede, Portugal, July 19 th , 2013. The meeting had the contribution of renowned speakers including Jeffrey Karp (Harvard University), Molly Stevens (Imperial College of London), Pedro Granja (INEB, University of Porto, Portugal), Stephen Minger (GE Healthcare, UK), Tim Allsop (Pfizer), Joaquim Cabral (IST, Portugal), Constanza Emanueli (University of Bristol), Marc Peschanski (I-STEM) and Ihor Lemischka (Mount Sinai School of Medicine). (2013/07/19 - 2013/07/19)

Participação em evento

Descrição da atividade
Tipo de evento 		Nome do evento
Instituição / Organização
2016/07/18 - 2016/07/22 Building Global innovators (Innovation accelerator) – Entrepreneurship course
Outro
 Building Global Innovators
ISCTE Business School, Portugal
2015/10/05 - 2015/10/09 Quantitative Fluorescence Microscopy Course
Oficina (workshop)
 Quantitative Fluorescence Microscopy Course
CNC.IBILI, Portugal
2009/11/02 - 2009/11/07 7th International Stem Cell School in Regenerative Medicine
Oficina (workshop)

Júri de grau académico

Tema
Tipo de participação 		Nome do candidato (Tipo de grau)
Instituição / Organização
2024/10/07 Transport of modulated extracellular vesicles transfected with microRNAs to the heart
Arguente principal
 Ana Sofia Menezes de Sousa (Mestrado)
Universidade de Coimbra, Portugal
2024/09/26 Targeting extracellular vesicles to ischemic endothelial cells
Arguente principal
 André Esperança (Mestrado)
Universidade de Coimbra, Portugal
2024/09/23 Exploring The Potential Of Iron Oxide Nanoparticles In Ultrasound For Glioblastoma Therapy
Arguente principal
 Joel Sérgio Jesus Barcelos (Mestrado)
Universidade de Coimbra, Portugal
2023/07/05 MicroRNAs-enriched exosomes as a new therapy for Parkinson’s disease.
Arguente principal
 Marta Carrola Esteves (Doutoramento)
Universidade da Beira Interior, Portugal
2023/04/06 Synaptic regulation by chronic stress-induced microRNAs
Arguente
 Beatriz Figueired Rodrigues (Doutoramento)
Universidade de Coimbra, Portugal
2022/09/30 Radiolabelling of Small Extracellular Vesicles for Diagnostics and Therapeutic Applications
Arguente principal
 Francisco Tejo (Mestrado)
Universidade de Coimbra, Portugal
2022/09/23 Nanoformulations for the treatment of vascular ageing
Arguente principal
 Joana Padrão (Mestrado)
Universidade de Coimbra, Portugal
2022/03/30 Vascular cell senescence: Triggers and therapeutic strategies
Arguente
 Rita Sá Ferreira (Doutoramento)
Universidade Nova de Lisboa, Portugal
2021/01/11 Biocompatible Nanoparticles to Modulate Cell Activity
Arguente
 Josephine Blersch (Doutoramento)
Universidade de Coimbra, Portugal
2018/12 Funcionalização de filmes finos plasmónicos de Au-TiO2 com elementos de bioreconhecimento para deteção de biomoléculas
Arguente principal
 Diana Isabela Faria Meira (Mestrado)
Universidade do Minho, Portugal
2018/12 Development of ZnO thin films for antimicrobial applications
Arguente principal
 Patrícia Alexandra Pereira da Silva (Mestrado)
Universidade do Minho, Portugal

Curso / Disciplina lecionado

Disciplina Curso (Tipo) Instituição / Organização
2018/09/01 - Atual Regenerative Medicine Ciências de Engenharia Biomédica (Licenciatura) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/01/12 - 2020/03/16 Biotechnology and Regenerative Medicine (Outros) Instituto de Educação e Cidadania, Portugal

Entrevista / Programa (rádio / tv)

Programa Tema
2019/01/29 - 2019/01/29 Rádio França Internacional - Magazine de Ciência

Membro de associação

Nome da associação Tipo de participação
2017/10 - Atual Controlled Release Society

Membro de comissão

Descrição da atividade
Tipo de participação 		Instituição / Organização
2019/07 - Atual Coordinator of the section Stem Cells and Tissue Engineering
Coordenador

Tutoria

Tópico Nome do aluno
2024/09 - Atual Development of ex vivo cardiac models Filipa Ferreira
2022/12/01 - Atual Extracellular vesicles to reverse cell senescence Cláudia Deus (Postdoctoral researcher)
2022/03 - Atual Study of anti-senescence properties of extracellular vesicles Susana Soares (MSc fellow)
2022/02/01 - Atual Neuroregeneration mechanisms of extracellular vesicles Magda Rodrigues (MSc felllow)
2022/07/01 - 2022/08/31 Extracellular vesicles targeting ischemic endothelial cells Juliana Floriano (Visiting postdoctoral researcher)
2022/06 - 2022/08 Interaction of nanogels with the blood brain barrier Roberta Bilardo (Visiting PhD student from Queen Mary University of London)
2020/11 - 2021/11 Inês Aires
2021/01 - 2021/04 Production and characterization of extracellular vesicles João Novo (MSc fellow)
2018/01/01 - 2021/03/31 Extracellular vesicles to treat brain ischemia Tiago Rondão (MSc fellow)
2020/07/01 - 2020/09/30 Functionalization of gold nanorods Natália Ferrari (Visiting MSc student)
2020/05/01 - 2020/09/30 Production of extracellular vesicles Clarissa Becher (MSc fellow)
2019/09/01 - 2020/03/31 Extracellular vesicles for the treatment of ischemic stroke Inês Morais (MSc fellow)
2020/01 - 2020/02 Cell culture; extracellular vesicle isolation and characterization Diana Pereira Gonçalves (Visiting undergraduate student)
2019/09/01 - 2019/10/01 Modification of extracellular vesicles with targeting peptides Francesco Catapano (visiting postdoctoral researcher)
2018/05/01 - 2018/05/31 Exosome isolation, characterization and modification strategies Luís Oliveira (MSc student)
Distinções

Prémio

2023 Best poster - Joint Meeting of the ETRS & SPCE-TC, Coimbra, 2023
2023 Best poster - 2nd PNEV meeting, Lisbon, 2023
2022 Best poster award
Meeting on Biosystems in Toxicology and Pharmacology , Portugal
2017 Best Poster Prize
CESB, Portugal
2017 Best Poster Prize
Sociedade Portuguesa de Células Estaminais e Terapias Celulares, Portugal

Outra distinção

2022 Mobility grant
COST, European Cooperation in Science and Technology, Bélgica
2021 Mobility grant
COST, European Cooperation in Science and Technology, Bélgica
2021 FCT Scientific Employment Stimulus Awardee
Fundação para a Ciência e a Tecnologia, Portugal
2011 PhD scholarship (sfrh/bd/81705/2011)
Fundação para a Ciência e a Tecnologia, Portugal
2009 Travel grant - 7th International Stem Cell School in Regenerative Medicine
European Union Marie Curie Conferences and Training Courses, Bélgica