William Lewis Sullivan Coutinho de Oliveira e Sousa Salvador (351A-98C4-E403)

Curriculum Vitae

William Lewis Sullivan Coutinho de Oliveira e Sousa Salvador

I am a research assistant at the Stem Cell Engineering Research Group (SCERG) of the Institute for Bioengineering and Biosciences (iBB) and the Associate Laboratory — Institute for Health and Bioeconomy (i4HB). My main work, carried out as part of a collaboration agreement between iBB and Phoenestra GmbH, an Austrian biotech startup, involves the use of stirred-tank bioreactors for the expansion of human induced pluripotent stem cells (hiPSCs) and the production of extracellular vesicles. Currently, I am also participating as a researcher in one of the ongoing projects at iBB, namely SMART, funded by Fundação para a Ciência e a Tecnologia. Additionally, I am enrolled as a PhD student in Bioengineering at Instituto Superior Técnico of the University of Lisbon. From September 2016 to February 2022, I attended the Integrated Master's in Biomedical Engineering program at NOVA School of Science and Technology (NOVA SST). During this time, I carried out internships at the Microbial Development Lab of the Instituto de Tecnologia Química e Biológica António Xavier (ITQB), where I conceived plasmid vectors and performed bacterial transformation, and the Neuronal Growth and Plasticity Lab of the Centro de Estudos de Doenças Crónicas (CEDOC), where I manipulated and studied Drosophila melanogaster animal models. I undertook my master's thesis at SCERG-iBB, with the objective of exploring and validating cost-efficient strategies for expanding hiPSCs in vertical-wheel bioreactors. For this purpose, I developed a computational tool for the economic modeling of an hiPSC expansion bioprocess and tested B8, a novel pluripotent cell culture medium. Upon graduating, I was distinguished with a NOVA SST Merit Scholarship and received the Best Engineering Student of NOVA SST and Best Biomedical Engineering Student of NOVA SST awards. To date, I have participated as a researcher in 1 concluded project, have published 2 articles in peer-reviewed journals, published 1 book chapter and participated in 12 scientific events, having carried out 8 poster and 2 oral presentations. The computational model I developed is open source and is available on GitHub (https://github.com/wssalvador/BEMSCA).

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Identificação

Identificação pessoal

Nome completo: William Lewis Sullivan Coutinho de Oliveira e Sousa Salvador
Data de nascimento: 1998/06/12
Género: Masculino

Nomes de citação

Salvador, William O.S.
Salvador, William

Identificadores de autor

Ciência ID: 351A-98C4-E403
ORCID iD: 0000-0002-5539-3433

Endereços de correio eletrónico

william.salvador@tecnico.ulisboa.pt (Profissional)
w.s.salvador@gmail.com (Pessoal)

Websites

http://scerg.tecnico.ulisboa.pt/wsalvador.html (Profissional)
https://ibb.tecnico.ulisboa.pt/people/members/William-Salvador/ (Profissional)

Domínios de atuação

Ciências Médicas e da Saúde - Biotecnologia Médica - Tecnologias que envolvem a Manipulação de Células,Tecidos,Órgãos ou todo o Organismo
Ciências da Engenharia e Tecnologias - Biotecnologia Industrial - Tecnologias de BioProcessamento

Idiomas

Idioma	Conversação	Leitura	Escrita	Compreensão	Peer-review
Inglês (Idioma materno)
Português (Idioma materno)

Formação

	Grau	Classificação
2022/04/05 - 2027/04/05 Em curso	Bioengineering (Doutoramento) Universidade de Lisboa Instituto Superior Técnico, Portugal "An Integrated Approach to the Production of Extracellular Vesicles from Human Induced Pluripotent Stem Cells in Stirred-Tank Bioreactors" (TESE/DISSERTAÇÃO)
2016/09/19 - 2022/02/05 Concluído	Biomedical Engineering (Mestrado integrado) Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal "Towards Cost-Efficient Culture of Human Induced Pluripotent Stem Cells in Vertical-Wheel Bioreactors" (TESE/DISSERTAÇÃO)	17/20 (1st cycle); 19/20 (2nd cycle); 20/20 (Thesis)

Percurso profissional

Ciência

	Categoria Profissional Instituição de acolhimento	Empregador
2022/04/01 - Atual	Assistente de Investigação (carreira) (Investigação)	Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
	Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Projetos

Bolsa

	Designação	Financiadores
2024/11/01 - 2027/10/31	An Integrated Process for the Production of Extracellular Vesicles from Human Induced Pluripotent Stem Cells in Stirred-Tank Bioreactors 2024.05042.BD Bolseiro de Doutoramento Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2023/01/13 - 2025/01/31	SMART - New technologies for Stem cell Manufacturing bioprocess monitoring and ARTificial intelligence-based modeling PTDC/EQU-EQU/3853/2020 Investigador Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Fundação para a Ciência e a Tecnologia Em curso
2022/11/01 - 2024/11/01	VitaminSea - Enhancing Cost-Effective and Efficient Nutrient Delivery in Fish Embryonic Stem Cell Culture Medium via Functional Bioactive Microcarriers 22-CM-PT-DG-1-317 Investigador Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Good Food Institute Concluído
2022/04/01 - 2024/10/31	Phoenestra (PhD Student Research Grant) 1801P.01165.1.01 Bolseiro de Doutoramento Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal	Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento Concluído

Produções

Publicações

Artigo em revista	Salvador, William O.S.; Nogueira, Diogo E.S.; Ferreira, Frederico; Joaquim M.S. Cabral; Rodrigues, Carlos A.V.. Autor correspondente: Rodrigues, Carlos A.V.. "BEMSCA: A novel decision support tool applied to the optimal design of a large-scale human induced pluripotent stem cell expansion bioprocess". Current Research in Biotechnology 6 (2023): http://dx.doi.org/10.1016/j.crbiot.2023.100163. Acesso aberto • Publicado • 10.1016/j.crbiot.2023.100163 Salvador, William O.S.; Inês A. B. Ribeiro; Nogueira, Diogo E.S.; Ferreira, Frederico; Joaquim M.S. Cabral; Rodrigues, Carlos A.V.. Autor correspondente: Rodrigues, Carlos A.V.. "Bioprocess Economic Modeling: Decision Support Tools for the Development of Stem Cell Therapy Products". Bioengineering 9 12 (2022): https://www.mdpi.com/2306-5354/9/12/791. Acesso aberto • Publicado • 10.3390/bioengineering9120791
Capítulo de livro	Salvador, William O.S.; Nogueira, Diogo E.S.; Bovolato, Ana L.C.; Ferreira, Frederico; Joaquim M.S. Cabral; Rodrigues, Carlos A.V.. Autor correspondente: Rodrigues, Carlos A.V.. "Bringing cellular agriculture to the table: the role of animal cell bioreactors". In Cellular Agriculture: Technology, Society, Sustainability and Science, editado por Fraser, Evan D.G.; Kaplan, David L.; Newman, Lenore; Yada, Rickey Y., 161-175. Elsevier, 2024. Publicado
Poster em conferência	Salvador, William O.S.; Nogueira, Diogo E.S.; Joaquim M.S. Cabral; Klaus Graumann; Rodrigues, Carlos A.V.. Autor correspondente: Rodrigues, Carlos A.V.. "Human Induced Pluripotent Stem Cell Culture in Stirred-Tank Bioreactors: Optimization and Automation of Feeding Strategies for Achieving Economic Viability". Trabalho apresentado em BioManufacturing Without Borders 2024, 2024. Salvador, William O.S.. "An Integrated Approach to the Production of Extracellular Vesicles from Human Induced Pluripotent Stem Cells in Stirred-Tank Bioreactors". Trabalho apresentado em PhD Open Days 2024 - 10th Edition, 2024. Salvador, William O.S.; Nogueira, Diogo E.S.; Joaquim M.S. Cabral; Klaus Graumann; Rodrigues, Carlos A.V.. Autor correspondente: Rodrigues, Carlos A.V.. "Stem Cell Culture in Stirred-Tank Bioreactors: Optimization and Automation of Feeding Strategies for Achieving Economic Viability". Trabalho apresentado em 2nd International Conference of the Portuguese Association for Cellular Agriculture, 2024. Salvador, William O.S.; Nogueira, Diogo E.S.; Ferreira, Frederico; Joaquim M.S. Cabral; Klaus Graumann; Rodrigues, Carlos A.V.. Autor correspondente: Rodrigues, Carlos A.V.. "An Integrated Approach to the Production of Extracellular Vesicles from Human Induced Pluripotent Stem Cells in Stirred-Tank Bioreactors". Trabalho apresentado em 3rd iBB Workshop, 2023. Salvador, William O.S.; Nogueira, Diogo E.S.; Ferreira, Frederico; Joaquim M.S. Cabral; Rodrigues, Carlos A.V.. Autor correspondente: Rodrigues, Carlos A.V.. "BEMSCA: A Novel Decision Support Tool for the Optimal Design of Large-Scale Stem Cell Expansion Bioprocesses". Trabalho apresentado em 1st International Conference of the Portuguese Association for Cellular Agriculture, 2023. Salvador, William O.S.; Nogueira, Diogo E.S.; Ferreira, Frederico; Joaquim M.S. Cabral; Rodrigues, Carlos A.V.. Autor correspondente: Rodrigues, Carlos A.V.. "BEMSCA: A Novel Decision Support Tool for Optimally Designing Large-Scale Stem Cell Expansion Bioprocesses". Trabalho apresentado em TERMIS-EU 2023, 2023. Salvador, William O.S.; Nogueira, Diogo E.S.; Ferreira, Frederico; Joaquim M.S. Cabral; Rodrigues, Carlos A.V.. Autor correspondente: Rodrigues, Carlos A.V.. "BEMSCA: A Novel Decision Support Tool for the Optimal Design of a Large-Scale Human Induced Pluripotent Stem Cell Expansion Bioprocess". Trabalho apresentado em 2nd iBB Workshop, 2022. Salvador, William O.S.; Nogueira, Diogo E.S.; Ferreira, Frederico; Joaquim M.S. Cabral; Rodrigues, Carlos A.V.. Autor correspondente: Rodrigues, Carlos A.V.. "BEMSCA: A Novel Decision Support Tool for the Optimal Design of a Large-Scale Human Induced Pluripotent Stem Cell Expansion Bioprocess". Trabalho apresentado em 27th ESACT Meeting, 2022.
Resumo em conferência	Salvador, William O.S.; Nogueira, Diogo E.S.; Ferreira, Frederico; Joaquim M.S. Cabral; Rodrigues, Carlos A.V.. Autor correspondente: Rodrigues, Carlos A.V.. "A Novel Decision Support Tool for Optimally Designing Large-Scale Stem Cell Expansion Bioprocesses". Trabalho apresentado em RESIM 2022, Leiria, 2022. Publicado
Tese / Dissertação	"Towards Cost-Efficient Culture of Human Induced Pluripotent Stem Cells in Vertical-Wheel Bioreactors". Mestrado, Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, 2022. http://hdl.handle.net/10362/138625.

Atividades

Apresentação oral de trabalho

	Título da apresentação	Nome do evento Anfitrião (Local do evento)
2024/11/29	Human Induced Pluripotent Stem Cell Culture in Stirred-Tank Bioreactors: Optimization and Automation of Feeding Strategies for Achieving Economic Viability	BioManufacturing Without Borders 2024 Portuguese Society for Stem Cells and Cell Therapies (Lisbon, Portugal)
2022/06/03	A Novel Decision Support Tool for Optimally Designing Large-Scale Stem Cell Expansion Bioprocesses	RESIM 2022 Politécnico de Leiria Centro para o Desenvolvimento Rápido e Sustentado de Produto (Leiria, Portugal)

Participação em evento

	Descrição da atividade Tipo de evento	Nome do evento Instituição / Organização
2024/11/04 - 2024/11/05	Poster presentation at the PhD Open Days 2024 - 10th Edition and participation in the activities of its scientific program. Exposição	PhD Open Days 2024 - 10th Edition Universidade de Lisboa Instituto Superior Técnico, Portugal
2024/10/04 - 2024/10/05	Poster presentation at the 2nd International Conference of the Portuguese Association for Cellular Agriculture and participation in the activities of its scientific program. Conferência	2nd International Conference of the Portuguese Association for Cellular Agriculture CellAgri Portugal, Portugal
2023/11/13 - 2023/11/13	Poster presentation at the 3rd iBB Workshop and participation in the activities of its scientific program. Conferência	3rd iBB Workshop Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2023/09/07 - 2023/09/08	Poster presentation at the 1st International Conference of the Portuguese Association for Cellular Agriculture and participation in the activities of its scientific program. Conferência	1st International Conference of the Portuguese Association for Cellular Agriculture CellAgri Portugal, Portugal
2023/06/22 - 2023/06/23	Participation in the 2nd PNEV Meeting. Conferência	2nd PNEV Meeting Portuguese Network on Extracellular Vesicles, Portugal
2023/03/28 - 2023/03/31	Poster presentation at the TERMIS-EU 2023 conference and participation in the activities of its scientific program. Conferência	TERMIS-EU 2023 Tissue Engineering and Regenerative Medicine International Society, Estados Unidos
2022/12/19 - 2022/12/19	Participation in the Associate Laboratory i4HB Kick-Off Meeting. Encontro	i4HB Kick-Off Meeting Institute for Health and Bioeconomy, Portugal
2022/10/28 - 2022/10/29	Participation in Small New World, a meeting organized jointly by the Austrian and German Societies for Extracellular Vesicles (ASEV and GSEV, respectively). Conferência	Small New World Austrian Society for Extracellular Vesicles, Áustria German Society for Extracellular Vesicles, Alemanha
2022/09/23 - 2022/09/23	Poster presentation at the 2nd iBB Workshop and participation in the activities of its scientific program. Conferência	2nd iBB Workshop Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
2022/06/26 - 2022/06/29	Poster presentation at the 27th ESACT Meeting and participation in the activities of its scientific program. Conferência	27th ESACT Meeting European Society for Animal Cell Technology, Alemanha
2021/09/03 - 2021/09/05	Participation in the Biomedical Engineering Summit, an event organized by the Associação Nacional de Estudantes de Engenharia Biomédica (ANEEB). Conferência	Biomedical Engineering Summit 2021 Associação Nacional de Estudantes de Engenharia Biomédica, Portugal
2016/05/30 - 2016/06/01	See description of the VIII Mostra de Ciência below. Exposição	X Mostra Nacional de Ciência Fundação da Juventude, Portugal Fundação EDP, Portugal
2015/05/28 - 2015/05/30	See description of the VIII Mostra de Ciência below. Exposição	IX Mostra Nacional de Ciência Fundação da Juventude, Portugal Fundação EDP, Portugal
2014/05/29 - 2014/05/31	Poster presentation at the VIII Mostra Nacional de Ciência, an annual event organized by Fundação da Juventude and Fundação EDP which recognizes and rewards promising young scientists and researchers at the national level. Exposição	VIII Mostra Nacional de Ciência Fundação da Juventude, Portugal Fundação EDP, Portugal

Distinções

Prémio

2022	Best Engineering Student 2020/21 Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022	Best Biomedical Engineering Student 2020/21 Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022	Merit Scholarship 2020/21 Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal Direção-Geral do Ensino Superior, Portugal